WO2013048222A3 - 실리카 합성 펩타이드 및 이의 용도 - Google Patents

실리카 합성 펩타이드 및 이의 용도 Download PDF

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Publication number
WO2013048222A3
WO2013048222A3 PCT/KR2012/007976 KR2012007976W WO2013048222A3 WO 2013048222 A3 WO2013048222 A3 WO 2013048222A3 KR 2012007976 W KR2012007976 W KR 2012007976W WO 2013048222 A3 WO2013048222 A3 WO 2013048222A3
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WO
WIPO (PCT)
Prior art keywords
silica
peptide
synthesizing
synthesizing silica
biosensor
Prior art date
Application number
PCT/KR2012/007976
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English (en)
French (fr)
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WO2013048222A2 (ko
Inventor
백승필
기미란
Original Assignee
고려대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 고려대학교 산학협력단 filed Critical 고려대학교 산학협력단
Priority to EP18197419.7A priority Critical patent/EP3456731A1/en
Priority to US14/348,322 priority patent/US9404097B2/en
Priority to EP12835950.2A priority patent/EP2762488B1/en
Priority to EP18197428.8A priority patent/EP3456732B1/en
Publication of WO2013048222A2 publication Critical patent/WO2013048222A2/ko
Publication of WO2013048222A3 publication Critical patent/WO2013048222A3/ko
Priority to US15/194,712 priority patent/US9920304B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 실리카 합성 펩타이드 및 이의 용도에 관한 것으로, 보다 상세하게는 상온, 상압, 중성 부근의 약염기 조건의 수용액 하에서 실리카 전구체로부터 실리카를 중합할 수 있는 실리카 합성 펩타이드를 제공한다. 상기 실리카 합성 펩타이드는 실리카 합성 시 자기조립 구조체를 형성할 수 있어 실리카 기반의 단백질 고정화, 바이오센서, 약물전달체 등 다양한 바이오소재로 사용할 수 있다.
PCT/KR2012/007976 2011-09-30 2012-10-02 실리카 합성 펩타이드 및 이의 용도 WO2013048222A2 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP18197419.7A EP3456731A1 (en) 2011-09-30 2012-10-02 Peptide for synthesizing silica, and use thereof
US14/348,322 US9404097B2 (en) 2011-09-30 2012-10-02 Peptide capable of silica deposition and use thereof
EP12835950.2A EP2762488B1 (en) 2011-09-30 2012-10-02 Peptide for synthesizing silica, and use thereof
EP18197428.8A EP3456732B1 (en) 2011-09-30 2012-10-02 Peptide for synthesizing silica, and use thereof
US15/194,712 US9920304B2 (en) 2011-09-30 2016-06-28 Peptide capable of silica deposition and use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20110100176 2011-09-30
KR20110100177 2011-09-30
KR10-2011-0100177 2011-09-30
KR10-2011-0100176 2011-09-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/348,322 A-371-Of-International US9404097B2 (en) 2011-09-30 2012-10-02 Peptide capable of silica deposition and use thereof
US15/194,712 Division US9920304B2 (en) 2011-09-30 2016-06-28 Peptide capable of silica deposition and use thereof

Publications (2)

Publication Number Publication Date
WO2013048222A2 WO2013048222A2 (ko) 2013-04-04
WO2013048222A3 true WO2013048222A3 (ko) 2013-08-01

Family

ID=47996670

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/007976 WO2013048222A2 (ko) 2011-09-30 2012-10-02 실리카 합성 펩타이드 및 이의 용도

Country Status (4)

Country Link
US (2) US9404097B2 (ko)
EP (3) EP2762488B1 (ko)
KR (1) KR101473059B1 (ko)
WO (1) WO2013048222A2 (ko)

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HUE051406T2 (hu) 2012-11-14 2021-03-01 Grace W R & Co Biológiailag aktív anyagot és rendezetlen szervetlen oxidot tartalmazó kompozíciók
KR101954125B1 (ko) * 2016-04-07 2019-03-05 고려대학교 세종산학협력단 서방형 생리활성물질 담지 골 이식재 및 이의 제조방법
KR101864375B1 (ko) * 2016-04-14 2018-07-13 고려대학교 세종산학협력단 바이오 실리카를 이용한 물질의 검출, 분리 또는 정제
KR102107515B1 (ko) * 2016-04-22 2020-05-07 고려대학교 세종산학협력단 실리카 합성을 위한 재조합 단백질 및 이의 용도
EP3323827A1 (en) * 2016-11-21 2018-05-23 Christian-Albrechts-Universität zu Kiel Cationic intrinsically disordered antimicrobial peptides
US10882885B2 (en) 2017-02-15 2021-01-05 Massachusetts Institute Of Technology Peptide-based synthetic molecules and silica nanostructures
WO2018193039A1 (en) * 2017-04-20 2018-10-25 Universität Wien Silaffin silica particle adjuvant
CN109806394B (zh) * 2017-11-18 2021-09-24 沈阳药科大学 一种介孔二氧化硅药物递送系统及其应用
CN109481739B (zh) * 2018-12-12 2021-07-30 四川大学华西医院 一种骨关节润滑剂及其制备方法
KR102401223B1 (ko) * 2019-02-15 2022-05-25 고려대학교 세종산학협력단 실리카 형성 펩타이드를 포함하는 링커 조성물
WO2020165883A2 (ko) * 2019-02-15 2020-08-20 고려대학교 세종산학협력단 신규의 실리카 합성 펩타이드 및 이를 이용한 실리카 입자 합성방법
US11633491B2 (en) * 2019-02-15 2023-04-25 Korea University Research And Business Foundation, Sejong Campus Linker composition comprising silica-forming peptides
KR102477868B1 (ko) * 2019-05-23 2022-12-15 고려대학교 세종산학협력단 EctP1 펩타이드 태그 및 상기 태그를 이용한 재조합 단백질의 고정화 또는 정제 방법
KR102332787B1 (ko) * 2019-05-28 2021-11-30 고려대학교 세종산학협력단 해양 유래 실리카 합성 펩타이드 및 이의 용도
KR102339006B1 (ko) * 2019-10-29 2021-12-14 영남대학교 산학협력단 효소와 실리카 형성 펩타이드 접합 고분자로 이루어진 마이셀을 포함하는 메조포러스 실리카 나노복합체 및 이의 제조 방법
KR102303322B1 (ko) * 2019-12-13 2021-09-24 고려대학교 세종산학협력단 약산성 및 중성 pH 범위의 실리카 합성 펩타이드
KR20210124078A (ko) 2020-04-06 2021-10-14 고려대학교 산학협력단 카테콜 및 바이오 실리카를 이용한 서방성 약물 전달체 및 이의 용도
KR102420704B1 (ko) * 2020-06-15 2022-07-14 경상국립대학교산학협력단 염 처리를 통해 실리카 나노입자에 고정화된 목적 단백질의 안정성을 증가시키는 방법
CN114588874B (zh) * 2020-12-04 2023-04-25 中国科学院大连化学物理研究所 一种基于海绵硅蛋白的多孔材料及制备和应用
KR20220144340A (ko) 2021-04-19 2022-10-26 고려대학교 세종산학협력단 실리카 합성용 조성물 및 이를 이용한 실리카 합성방법

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Also Published As

Publication number Publication date
US20160376575A1 (en) 2016-12-29
US9920304B2 (en) 2018-03-20
WO2013048222A2 (ko) 2013-04-04
EP3456731A1 (en) 2019-03-20
US9404097B2 (en) 2016-08-02
EP2762488A2 (en) 2014-08-06
EP3456732B1 (en) 2020-04-29
EP3456732A1 (en) 2019-03-20
US20140255309A1 (en) 2014-09-11
EP2762488A4 (en) 2015-08-26
KR101473059B1 (ko) 2014-12-26
KR20130035985A (ko) 2013-04-09
EP2762488B1 (en) 2018-11-21

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