WO2012157978A3 - 팥꽃나무 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 아토피 예방 또는 치료용 약학적 조성물 - Google Patents

팥꽃나무 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 아토피 예방 또는 치료용 약학적 조성물 Download PDF

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Publication number
WO2012157978A3
WO2012157978A3 PCT/KR2012/003903 KR2012003903W WO2012157978A3 WO 2012157978 A3 WO2012157978 A3 WO 2012157978A3 KR 2012003903 W KR2012003903 W KR 2012003903W WO 2012157978 A3 WO2012157978 A3 WO 2012157978A3
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WO
WIPO (PCT)
Prior art keywords
extracts
atopic dermatitis
preventing
pharmaceutical composition
composition containing
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PCT/KR2012/003903
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English (en)
French (fr)
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WO2012157978A2 (ko
Inventor
김재화
안경섭
강호범
오세량
고재종
김주헌
손장미
송재성
오현우
지다정
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한국생명공학연구원
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Priority to CN201280035568.6A priority Critical patent/CN103747794B/zh
Priority to US14/117,737 priority patent/US9428520B2/en
Priority to EP12784901.6A priority patent/EP2711014B1/en
Publication of WO2012157978A2 publication Critical patent/WO2012157978A2/ko
Publication of WO2012157978A3 publication Critical patent/WO2012157978A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/10—Cereal-derived products
    • A23L7/198—Dry unshaped finely divided cereal products, not provided for in groups A23L7/117 - A23L7/196 and A23L29/00, e.g. meal, flour, powder, dried cereal creams or extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Abstract

본 발명은 팥꽃나무(Daphne genkwa) 추출물, 이의 분획물 또는 하기 화학식 1의 분리한 화합물을 유효성분으로 함유하는 아토피 예방 또는 치료용 약학적 조성물에 관한 것으로, 보다 구체적으로 본 발명에 따른 상기 팥꽃나무 추출물, 분획물 또는 이로부터 분리한 화합물인 겐크와다프닌(Genekwadapnin) 또는 유안후아신(yuanhuacine)은 면역세포 Th1 사이토카인 분비량을 효과적으로 증가시키고, 아토피 마우스 동물 모델에서 아토피 억제 효능을 나타내므로 아토피의 예방 또는 치료에 유용하게 사용될 수 있다:
PCT/KR2012/003903 2011-05-17 2012-05-17 팥꽃나무 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 아토피 예방 또는 치료용 약학적 조성물 WO2012157978A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201280035568.6A CN103747794B (zh) 2011-05-17 2012-05-17 用于预防或治疗特应性皮炎的芫花提取物以及含有该提取物的部位或从该提取物分离的化合物作为活性成分的药物组合物
US14/117,737 US9428520B2 (en) 2011-05-17 2012-05-17 Daphne genkwa extracts, and pharmaceutical composition containing fractions of the extracts or compounds separated from the extracts as active ingredients for preventing or treating atopic dermatitis
EP12784901.6A EP2711014B1 (en) 2011-05-17 2012-05-17 Daphne genkwa extracts, and pharmaceutical composition containing fractions of the extracts or compounds separated from the extracts as active ingredients for preventing or treating atopic dermatitis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2011-0046274 2011-05-17
KR20110046274 2011-05-17
KR10-2012-0052441 2012-05-17
KR1020120052441A KR101364234B1 (ko) 2011-05-17 2012-05-17 팥꽃나무 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 아토피 예방 또는 치료용 약학적 조성물

Publications (2)

Publication Number Publication Date
WO2012157978A2 WO2012157978A2 (ko) 2012-11-22
WO2012157978A3 true WO2012157978A3 (ko) 2013-03-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/003903 WO2012157978A2 (ko) 2011-05-17 2012-05-17 팥꽃나무 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 아토피 예방 또는 치료용 약학적 조성물

Country Status (5)

Country Link
US (1) US9428520B2 (ko)
EP (1) EP2711014B1 (ko)
KR (1) KR101364234B1 (ko)
CN (1) CN103747794B (ko)
WO (1) WO2012157978A2 (ko)

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ITRM20130657A1 (it) * 2013-11-27 2015-05-28 Gallo Gioacchino Folino Trattamento delle dermatopatie mediante estratto vegetale di daphne laureola
KR101692889B1 (ko) * 2014-01-09 2017-01-04 한국생명공학연구원 두메닥나무 추출물 또는 이의 분획물을 포함하는 염증성 질환의 예방 또는 치료용 조성물
KR101859196B1 (ko) * 2016-11-14 2018-05-17 한국생명공학연구원 팥꽃나무 꽃 추출물 또는 이의 분획물을 유효성분으로 포함하는 신경퇴행성 질환 예방 또는 치료용 약학 조성물
KR101935371B1 (ko) 2018-05-17 2019-01-07 부산대학교 산학협력단 말톨, 이소소이아말로사이드 i 또는 이들의 혼합물을 유효성분으로 함유하는 아토피성 피부염 예방 또는 치료용 조성물
EP3666250A1 (en) 2018-12-10 2020-06-17 ETH Zurich Cosmetic preparations comprising daphne extracts
CN109480019A (zh) * 2019-01-22 2019-03-19 安徽农业大学 一种功能性桔梗姜茶及其制备方法
KR20200109026A (ko) 2019-03-12 2020-09-22 인천대학교 산학협력단 팥꽃나무 및 감수 복합 추출물을 유효성분으로 포함하는 면역기능 증진용 조성물
CN109970698B (zh) * 2019-04-22 2021-07-27 广西中医药大学 具有抗氧化作用的化合物及其制备方法和用途
CN113274438A (zh) * 2021-05-24 2021-08-20 上海交通大学 芫花提取物的制备及其应用
CN114225091B (zh) * 2021-11-18 2022-12-02 朗姿赛尔生物科技（广州）有限公司 一种生物酶伤口创面敷料及其制备方法
KR102616141B1 (ko) * 2023-08-18 2023-12-19 정지영 에이트 컴플렉스를 함유하여 피부 염증과 피부 가려움증을 개선하는 비건 화장료 조성물
KR102630567B1 (ko) * 2023-09-26 2024-01-29 정지영 에이트 컴플렉스 함유물질에 따라 피부 흡수율 증진효과를 갖는 리포좀 조성물 및 이의 제조방법

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Also Published As

Publication number Publication date
CN103747794A (zh) 2014-04-23
EP2711014A4 (en) 2014-12-17
WO2012157978A2 (ko) 2012-11-22
US9428520B2 (en) 2016-08-30
CN103747794B (zh) 2017-05-10
EP2711014B1 (en) 2017-06-07
US20140072664A1 (en) 2014-03-13
KR20120128579A (ko) 2012-11-27
EP2711014A2 (en) 2014-03-26
KR101364234B1 (ko) 2014-02-17

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