WO2012134188A2 - 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 - Google Patents
신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 Download PDFInfo
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- WO2012134188A2 WO2012134188A2 PCT/KR2012/002314 KR2012002314W WO2012134188A2 WO 2012134188 A2 WO2012134188 A2 WO 2012134188A2 KR 2012002314 W KR2012002314 W KR 2012002314W WO 2012134188 A2 WO2012134188 A2 WO 2012134188A2
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- 0 CBrc1ccc(N(*)CCNN*2CC2)nc1 Chemical compound CBrc1ccc(N(*)CCNN*2CC2)nc1 0.000 description 11
- FAKNGMZQDWEMRC-UHFFFAOYSA-N CN1C(c(nc2)ccc2Br)=NOCC1 Chemical compound CN1C(c(nc2)ccc2Br)=NOCC1 FAKNGMZQDWEMRC-UHFFFAOYSA-N 0.000 description 3
- WGOLHUGPTDEKCF-UHFFFAOYSA-N Nc(cc1)ncc1Br Chemical compound Nc(cc1)ncc1Br WGOLHUGPTDEKCF-UHFFFAOYSA-N 0.000 description 3
- MCJGNBDKXYUSIK-UHFFFAOYSA-N NNCCNc(nc1)ccc1Br Chemical compound NNCCNc(nc1)ccc1Br MCJGNBDKXYUSIK-UHFFFAOYSA-N 0.000 description 2
- HXGWXRDEVDATIV-VIFPVBQESA-O [BH+]c(ccc(N(C[C@H](CNC(C)=O)O1)C1=O)c1)c1F Chemical compound [BH+]c(ccc(N(C[C@H](CNC(C)=O)O1)C1=O)c1)c1F HXGWXRDEVDATIV-VIFPVBQESA-O 0.000 description 2
- KVJKHMARIBHXHI-VIFPVBQESA-N Bc(ccc(N(C[C@H](CNC(C)=O)O1)C1=O)c1)c1F Chemical compound Bc(ccc(N(C[C@H](CNC(C)=O)O1)C1=O)c1)c1F KVJKHMARIBHXHI-VIFPVBQESA-N 0.000 description 1
- ZHXUWDPHUQHFOV-UHFFFAOYSA-N Brc(cc1)cnc1Br Chemical compound Brc(cc1)cnc1Br ZHXUWDPHUQHFOV-UHFFFAOYSA-N 0.000 description 1
- XFKOJUMFSDOSGO-UHFFFAOYSA-N Brc(cc1)cnc1C1=NOCCN1 Chemical compound Brc(cc1)cnc1C1=NOCCN1 XFKOJUMFSDOSGO-UHFFFAOYSA-N 0.000 description 1
- RRVFPUAHTSKNJO-UHFFFAOYSA-N Brc1ccc(N2C=NOCC2)nc1 Chemical compound Brc1ccc(N2C=NOCC2)nc1 RRVFPUAHTSKNJO-UHFFFAOYSA-N 0.000 description 1
- ONVUSVONUIOIKV-UHFFFAOYSA-N C=CCNc(nc1)ccc1Br Chemical compound C=CCNc(nc1)ccc1Br ONVUSVONUIOIKV-UHFFFAOYSA-N 0.000 description 1
- LQFWPJXQYDBHEC-LBPRGKRZSA-O CC(C)(C(C)(C)OBc(c(F)c1)ccc1N(C[C@H](CNC(OC)=O)O1)C1=O)[OH2+] Chemical compound CC(C)(C(C)(C)OBc(c(F)c1)ccc1N(C[C@H](CNC(OC)=O)O1)C1=O)[OH2+] LQFWPJXQYDBHEC-LBPRGKRZSA-O 0.000 description 1
- PYJSRXYLRDLQQZ-LLVKDONJSA-N CC(C)(C(C)(C)OBc(ccc(N(C[C@H](CO)O1)C1=O)c1)c1F)O Chemical compound CC(C)(C(C)(C)OBc(ccc(N(C[C@H](CO)O1)C1=O)c1)c1F)O PYJSRXYLRDLQQZ-LLVKDONJSA-N 0.000 description 1
- PIWFWNZGXXOWLI-UHFFFAOYSA-N CC(C)(C(C)(C)OSc(ccc(N(CC(CO)O1)C1=O)c1)c1F)OC Chemical compound CC(C)(C(C)(C)OSc(ccc(N(CC(CO)O1)C1=O)c1)c1F)OC PIWFWNZGXXOWLI-UHFFFAOYSA-N 0.000 description 1
- VWDBPIGYFXZGQJ-LBPRGKRZSA-O CC(C)(C(C)(C)O[B+]c(c(F)c1)ccc1N(C[C@H](CNC(OC)=O)O1)C1=O)O Chemical compound CC(C)(C(C)(C)O[B+]c(c(F)c1)ccc1N(C[C@H](CNC(OC)=O)O1)C1=O)O VWDBPIGYFXZGQJ-LBPRGKRZSA-O 0.000 description 1
- AHQWQYXKNBYQPH-LBPRGKRZSA-N CC(C)(C(C)(C)O[BH2-]c(c(F)c1)ccc1N(C[C@H](CNC(OC)=O)O1)C1=O)O Chemical compound CC(C)(C(C)(C)O[BH2-]c(c(F)c1)ccc1N(C[C@H](CNC(OC)=O)O1)C1=O)O AHQWQYXKNBYQPH-LBPRGKRZSA-N 0.000 description 1
- KINRIDTWWCKQQV-LCQOSCCDSA-N CC(C)(OC1)OC1C(N(CC1)N=CN1c(cc1)ncc1-c(ccc(N(C[C@H](COC1=N[O]=CC1)O1)C1=O)c1)c1F)=O Chemical compound CC(C)(OC1)OC1C(N(CC1)N=CN1c(cc1)ncc1-c(ccc(N(C[C@H](COC1=N[O]=CC1)O1)C1=O)c1)c1F)=O KINRIDTWWCKQQV-LCQOSCCDSA-N 0.000 description 1
- OZPFVBLDYBXHAF-UHFFFAOYSA-N CC(C)(OC1)OC1C(O)=O Chemical compound CC(C)(OC1)OC1C(O)=O OZPFVBLDYBXHAF-UHFFFAOYSA-N 0.000 description 1
- MIPGZIIXIWKATQ-UHFFFAOYSA-O CC(C)(OC1)OC1C([NH2+]CCN(C=N)c(cc1)ncc1-c(ccc(N(CC(COC1=N[O]=CC1)O1)C1=O)c1)c1F)=O Chemical compound CC(C)(OC1)OC1C([NH2+]CCN(C=N)c(cc1)ncc1-c(ccc(N(CC(COC1=N[O]=CC1)O1)C1=O)c1)c1F)=O MIPGZIIXIWKATQ-UHFFFAOYSA-O 0.000 description 1
- WHQOGTODCZDKSG-UHFFFAOYSA-N CC(NCC(CN1c2ccc(-c(cc3)cnc3N3C=NNCC3)c(F)c2)OC1=O)=O Chemical compound CC(NCC(CN1c2ccc(-c(cc3)cnc3N3C=NNCC3)c(F)c2)OC1=O)=O WHQOGTODCZDKSG-UHFFFAOYSA-N 0.000 description 1
- VUYDHSKOWDVQIV-VIQWUECVSA-N CC(NC[C@@H](CN1C(C=CC2c(cc3)cnc3N(CCNCO)C=N)=CC2F)OC1=O)=O Chemical compound CC(NC[C@@H](CN1C(C=CC2c(cc3)cnc3N(CCNCO)C=N)=CC2F)OC1=O)=O VUYDHSKOWDVQIV-VIQWUECVSA-N 0.000 description 1
- HWJWHMVPIQAHIM-INIZCTEOSA-N CC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3C3=NOCCN3C)c(F)c2)OC1=O)=O Chemical compound CC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3C3=NOCCN3C)c(F)c2)OC1=O)=O HWJWHMVPIQAHIM-INIZCTEOSA-N 0.000 description 1
- WHQOGTODCZDKSG-INIZCTEOSA-N CC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3N3C=NNCC3)c(F)c2)OC1=O)=O Chemical compound CC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3N3C=NNCC3)c(F)c2)OC1=O)=O WHQOGTODCZDKSG-INIZCTEOSA-N 0.000 description 1
- SNLBMUAGWKYVAK-KRWDZBQOSA-N CC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3NCCN(C=N)C=O)c(F)c2)OC1=O)=O Chemical compound CC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3NCCN(C=N)C=O)c(F)c2)OC1=O)=O SNLBMUAGWKYVAK-KRWDZBQOSA-N 0.000 description 1
- CFSOFGLMMFOIKJ-SFHVURJKSA-N CCN(CC1)C=NN1c(cc1)ncc1-c(ccc(N(C[C@H](CNC(C)=O)O1)C1=O)c1)c1F Chemical compound CCN(CC1)C=NN1c(cc1)ncc1-c(ccc(N(C[C@H](CNC(C)=O)O1)C1=O)c1)c1F CFSOFGLMMFOIKJ-SFHVURJKSA-N 0.000 description 1
- IIDUUOSFCLFSNV-UHFFFAOYSA-N CCN(CCNc(nc1)ccc1Br)C=N Chemical compound CCN(CCNc(nc1)ccc1Br)C=N IIDUUOSFCLFSNV-UHFFFAOYSA-N 0.000 description 1
- XWFPILKGUHZEKQ-IBGZPJMESA-N CCOC(CN(CC1)N=CN1c(cc1)ncc1-c(c(F)c1)ccc1N(C[C@H](CNC(C)=O)O1)C1=O)=O Chemical compound CCOC(CN(CC1)N=CN1c(cc1)ncc1-c(c(F)c1)ccc1N(C[C@H](CNC(C)=O)O1)C1=O)=O XWFPILKGUHZEKQ-IBGZPJMESA-N 0.000 description 1
- DEGAMJIBVPSSLN-UHFFFAOYSA-N CC[O](C)CNCCNc(nc1)ccc1Br Chemical compound CC[O](C)CNCCNc(nc1)ccc1Br DEGAMJIBVPSSLN-UHFFFAOYSA-N 0.000 description 1
- DEQRAMPYFYBVSK-HNNXBMFYSA-N CN1C(c(cc2)ncc2-c(c(F)c2)ccc2N(C[C@H](CNC(OC)=O)O2)C2=O)=NOCC1 Chemical compound CN1C(c(cc2)ncc2-c(c(F)c2)ccc2N(C[C@H](CNC(OC)=O)O2)C2=O)=NOCC1 DEQRAMPYFYBVSK-HNNXBMFYSA-N 0.000 description 1
- CLJQYJIZKCXBBQ-CQSZACIVSA-N CN1C(c(cc2)ncc2-c(ccc(N(C[C@H](CO)O2)C2=O)c2)c2F)=NOCC1 Chemical compound CN1C(c(cc2)ncc2-c(ccc(N(C[C@H](CO)O2)C2=O)c2)c2F)=NOCC1 CLJQYJIZKCXBBQ-CQSZACIVSA-N 0.000 description 1
- RYTREWILXDQWOQ-AWEZNQCLSA-N COC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3C3=NOCCN3)c(F)c2)OC1=O)=O Chemical compound COC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3C3=NOCCN3)c(F)c2)OC1=O)=O RYTREWILXDQWOQ-AWEZNQCLSA-N 0.000 description 1
- SSNMQWZHMISLIO-HNNXBMFYSA-N COC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3N(CCO)C=N)c(F)c2)OC1=O)=O Chemical compound COC(NC[C@@H](CN1c2ccc(-c(cc3)cnc3N(CCO)C=N)c(F)c2)OC1=O)=O SSNMQWZHMISLIO-HNNXBMFYSA-N 0.000 description 1
- UHDHLHZYZZIAOA-UHFFFAOYSA-N C[BrH]c(cc1)cnc1NCCNN Chemical compound C[BrH]c(cc1)cnc1NCCNN UHDHLHZYZZIAOA-UHFFFAOYSA-N 0.000 description 1
- AVMUNSLDRJYDRD-NTXOUDCCSA-N C[C@@H](C(/C=N\C)NCCN)Br Chemical compound C[C@@H](C(/C=N\C)NCCN)Br AVMUNSLDRJYDRD-NTXOUDCCSA-N 0.000 description 1
- SGSLWDRUUOLTGG-UHFFFAOYSA-N N=CN(CCNc(nc1)ccc1Br)C=O Chemical compound N=CN(CCNc(nc1)ccc1Br)C=O SGSLWDRUUOLTGG-UHFFFAOYSA-N 0.000 description 1
- VWMVNLDPFWNZAH-CQSZACIVSA-N N=CN(CCO)c(cc1)ncc1-c(ccc(N(C[C@H](CO)O1)C1=O)c1)c1F Chemical compound N=CN(CCO)c(cc1)ncc1-c(ccc(N(C[C@H](CO)O1)C1=O)c1)c1F VWMVNLDPFWNZAH-CQSZACIVSA-N 0.000 description 1
- KFNLGECTLKUJHQ-UHFFFAOYSA-O N=CN(CC[NH2+]C(C(CO)O)=O)c(cc1)ncc1-c(c(F)c1)ccc1N(CC(COC1=N[O]=CC1)O1)C1=O Chemical compound N=CN(CC[NH2+]C(C(CO)O)=O)c(cc1)ncc1-c(c(F)c1)ccc1N(CC(COC1=N[O]=CC1)O1)C1=O KFNLGECTLKUJHQ-UHFFFAOYSA-O 0.000 description 1
- YCIICVSFRSRECA-UHFFFAOYSA-N NCCN(c(nc1)ccc1Br)N Chemical compound NCCN(c(nc1)ccc1Br)N YCIICVSFRSRECA-UHFFFAOYSA-N 0.000 description 1
- XFONXXFGGBVGQU-MRXNPFEDSA-N O=C1O[C@@H](COC2=N[O]=CC2)CN1c1ccc(-c(cc2)cnc2N2C=NNCC2)c(F)c1 Chemical compound O=C1O[C@@H](COC2=N[O]=CC2)CN1c1ccc(-c(cc2)cnc2N2C=NNCC2)c(F)c1 XFONXXFGGBVGQU-MRXNPFEDSA-N 0.000 description 1
- PBMUHXCAWOYSDG-UHFFFAOYSA-O O=CC[NH2+]c(cc1)ncc1Br Chemical compound O=CC[NH2+]c(cc1)ncc1Br PBMUHXCAWOYSDG-UHFFFAOYSA-O 0.000 description 1
- SPEXAKNXIPSZMG-UHFFFAOYSA-N O=CN(CC1)C=NN1c(nc1)ccc1Br Chemical compound O=CN(CC1)C=NN1c(nc1)ccc1Br SPEXAKNXIPSZMG-UHFFFAOYSA-N 0.000 description 1
- XULJGNNKYZEGKP-UHFFFAOYSA-N O=CN(CC1)N=CN1c(cc1)ncc1Br Chemical compound O=CN(CC1)N=CN1c(cc1)ncc1Br XULJGNNKYZEGKP-UHFFFAOYSA-N 0.000 description 1
- UGBKYDASQNOIHP-SSDOTTSWSA-N OC[C@@H](CN1c(cc2F)ccc2Br)OC1=O Chemical compound OC[C@@H](CN1c(cc2F)ccc2Br)OC1=O UGBKYDASQNOIHP-SSDOTTSWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Definitions
- the present invention relates to novel oxazolidinone derivatives, in particular novel oxazolidinone derivatives comprising cyclic amidoxime or cyclic amidrazon groups.
- the present invention also relates to a pharmaceutical composition for antibiotics containing such an oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof and a pharmaceutically acceptable salt thereof as an active ingredient.
- the cyclic amidrazon group may have a weak basicity to form a salt, and in the case of hydrochloride, pKa is about 5, and has an acidity similar to acetic acid. Due to this weak acidic properties, the solubility in water can be greatly increased without degrading the antibacterial ability.
- a novel oxazolidinone derivative represented by the formula (1) in particular a novel oxazolidinone having a cyclic amidoxime or a cyclic amidrazon group. It was confirmed that the compound has an excellent antimicrobial activity compared to conventional antibiotics and has a high solubility that facilitates the development of oral and injectables, while having a superior effect on linezolide resistant bacteria, and the present invention was completed based on this.
- the first object of the present invention is to provide a compound represented by the formula (1).
- It is a third object of the present invention to provide a pharmaceutical composition comprising the compound and a method for antibiotic treatment using the compound in an effective amount.
- the present invention relates to novel oxazolidinone derivatives represented by the general formula (1), in particular novel oxazolidinone compounds having cyclic amidoxime or cyclic amidazone groups.
- the present invention also provides novel oxazolidinone derivatives of formula 1, prodrugs thereof, hydrates thereof, solvates thereof, isomers thereof and pharmaceutically acceptable salts thereof.
- R is a hetero ring selected from the structure:
- R 1 is hydrogen, C 1 -C 6 alkyl or C 3 -C 6 cycloalkyl
- R 2 is hydrogen, C 1 -C 6 alkyl or (CH 2 ) m C ( ⁇ O) R 21 ;
- R 21 is hydrogen, (CH 2 ) n NHR 211 , CH 2 OH or CH (OH) CH 2 OH, wherein R 211 is hydrogen or C 1 -C 6 alkyl;
- n are each independently an integer from 0 to 3;
- R 3 is hydrogen, C 1 -C 6 alkyl, —C ( ⁇ O) R 31 or a heteroaromatic ring selected from the structure:
- R 31 is hydrogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl or O- (C 1 -C 6 ) alkyl.
- the compounds of the present invention are novel compounds with little structural research.
- the incorporation of cyclic amidazone or cyclic amidoxime groups into the oxazolidinone antibiotics could greatly improve the absorbency, and with the proper basicity, salts could be formed to significantly increase the solubility in water.
- the increased solubility in water makes it possible to make injections without taking prodrugs and shows no significant toxicity.
- the oxazolidinone derivatives of the present invention are Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis, which are resistant to conventional antibiotics at much lower concentrations than commercially available linezolids, such as Gram-positive bacteria, Haemophilus influenzae, and Moraxella. It exhibits antimicrobial activity against Gram-negative bacteria such as catarralis, and particularly excellent against linezolide resistant enterococcus fascia.
- alkyl' as used herein includes both straight and branched chain structures.
- C 1 -C 6 alkyl includes all possible positions and geometric isomers such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl and hexyl.
- C 3 -C 6 cycloalkyl examples include the possible positions and geometric isomers of all ring forms such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cyclopropylmethyl.
- Preferred examples of the oxazolidinone derivative of Chemical Formula 1 according to the present invention are compounds selected from Chemical Formulas 2 to 4.
- R 2 and Q are the same as defined in Formula 1 above.
- R 2 may be methyl, C ( ⁇ O) CH 2 OH, C ( ⁇ O) CH 2 NH 2 or C ( ⁇ O) CH (OH) CH 2 OH.
- novel oxazolidinone derivatives according to the present invention may be exemplified by the following compounds, but the following compounds do not limit the present invention.
- novel oxazolidinone derivatives according to the present invention can be used in the form of prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts to enhance absorption in vivo or increase solubility. Hydrates, solvates, isomers and pharmaceutically acceptable salts are also within the scope of the present invention. The terms used herein will be briefly described.
- pharmaceutically acceptable salt means a formulation of a compound that does not cause severe irritation to the organism to which the compound is administered and does not impair the biological activity and properties of the compound.
- hydrate solvate
- isomer isomer
- prodrug also have the same meaning as above.
- the pharmaceutical salts are acids that form non-toxic acid addition salts containing pharmaceutically acceptable anions, such as inorganic acids, tartaric acid, formic acid, such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrobromic acid, hydroiodic acid, and the like.
- Organic carbon acids such as citric acid, acetic acid, trichloroacetic acid, trichloroacetic acid, gluconic acid, benzoic acid, lactic acid, fumaric acid, maleic acid, salicylic acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, etc. Acid addition salts formed by the same sulfonic acid and the like.
- carboxylic acid salts include metal salts or alkaline earth metal salts formed with lithium, sodium, potassium, calcium, magnesium, amino acid salts such as lysine, arginine, guanidine, dicyclohexylamine, N Organic salts such as -methyl-D-glucamine, tris (hydroxymethyl) methylamine, diethanolamine, choline and triethylamine and the like.
- amino acid salts such as lysine, arginine, guanidine, dicyclohexylamine, N Organic salts such as -methyl-D-glucamine, tris (hydroxymethyl) methylamine, diethanolamine, choline and triethylamine and the like.
- amino acid salts such as lysine, arginine, guanidine, dicyclohexylamine, N Organic salts such as -methyl-D-glucamine, tris (hydroxymethyl) methylamine, diethanolamine, choline and triethylamine and the
- hydrate refers to a compound of the present invention comprising a stoichiometric or non-stoichiometric amount of water bound by a non-covalent intermolecular force. Or salts thereof.
- solvate refers to a compound of the present invention or a salt thereof comprising a stoichiometric or non stoichiometric amount of solvent bound by non-covalent intermolecular forces.
- Preferred solvents therein are volatile, non-toxic, and / or solvents suitable for administration to humans.
- isomers means a compound of the present invention or a salt thereof that has the same chemical formula or molecular formula, but which is structurally or stericly different.
- isomers include both structural isomers such as tautomers, and stereoisomers such as R or S isomers having an asymmetric carbon center and geometric isomers (trans, cis). All these isomers and mixtures thereof are also within the scope of the present invention.
- prodrug refers to a substance that is transformed into a parent drug in vivo.
- Prodrugs are often used because, in some cases, they are easier to administer than the parent drug. For example, they may be bioavailable by oral administration, while the parent drug may not. Prodrugs may also have improved solubility in pharmaceutical compositions than the parent drug.
- the prodrug may be an in vivo hydrolyzable ester of a compound according to the invention and a pharmaceutically acceptable salt thereof.
- Another example of a prodrug may be a short peptide (polyamino acid) that is bound to an acid group which is converted by metabolism to reveal the active site.
- prodrugs according to the present invention include the following compounds.
- prodrugs are mainly used when the solubility is relatively low or the absorption is low, and switching to prodrug increases the solubility and absorption, as well as improves the absorption, distribution, metabolism, excretion (ADME) and PK profiles.
- Compounds of the invention have a chiral center at the C-5 position of the oxazolidinone ring.
- Preferred diastereomers of the oxazolidinone derivative compounds according to the present invention are as shown in Formula 1 above, and show better efficacy compared to epimers such as Formula 1b.
- the compound of formula (1) or salts thereof may exhibit tautomer phenomena, and although the formulas or schemes in the present specification represent only one possible tautomeric form, the present invention exhibits antimicrobial activity. It includes, but is not limited to, one tautomeric form having any tautomeric form with which it is used within the formula or scheme.
- the compound of the present invention may also exhibit polymorphism, and any homogenous compound having antimicrobial activity is also included in the present invention.
- novel oxazolidinone derivative compounds according to the present invention can be prepared by a variety of methods known depending on the type of substituents thereof, for example, can be prepared according to the method illustrated in the following scheme. It is apparent that the preparation method shown in the following scheme is merely an example and can be easily modified by those skilled in the art according to specific substituents, and thus the method illustrated in the following scheme is limited to preparing the oxazolidinone compound according to the present invention. Unless otherwise stated, the definition of the substituent in the following scheme is the same as defined in the formula (1).
- the compound of Formula 1 is synthesized through a coupling reaction between A part, which is a bromopyridine moiety having a cyclic amidoxime or cyclic amidazol group, and B part having an oxazolidinone group.
- various derivatives may be added to the R 'portion to convert to the R group, and the Y portion may be converted to the Q group to react with various derivatives to finally synthesize the compound of Formula 1.
- Y may be formed by introducing the same group as Q defined in Chemical Formula 1, and Y may be various reaction intermediate groups including Q.
- R ' may be various reaction intermediate groups including R as defined in Formula 1.
- Compound XII was prepared by attaching a Boc group to compound XI obtained by reacting dibromopyridine with ethylenediamine. The compound was subjected to an amination reaction with NaNO 2 and Zn, and then treated with an acid and reacted with an orthoester to synthesize Compound A-III.
- the synthesis of a derivative in which an alkyl group is introduced is performed by alkylating compound XII to form compound XV in which alkyl group is first introduced, and then introducing the alkyl group through amination reaction between amination and an orthoester. IV was synthesized.
- compound XVII is synthesized by reacting dibromopyridine with ethanolamine, compound XVIII is formed through hydroxyphthalimide and Mitsnov reaction, phthalimide is removed with hydrazine, and compound AV is obtained by cyclization reaction with orthoester.
- ethanolamine ethanolamine
- compound XVIII is formed through hydroxyphthalimide and Mitsnov reaction
- phthalimide is removed with hydrazine
- compound AV is obtained by cyclization reaction with orthoester.
- N- alkyl amine is a Boc 2 O and the reaction was back-hydroxy phthalimide and Mitsui through the knob reaction to create a compound XX by treatment with hydrochloric acid to remove the phthalimide to mid back hydrazine remove the Boc group by an alkyl group introduced into R1
- Compound XXI was synthesized.
- alkyl group R1 is introduced later.
- compound XXII is made from ethanolamine through a Mitsnov reaction, treated with hydrochloric acid to make compound XXIII, and then reacted with aldehyde to make compound XXIV having alkyl group R1 introduced therein. Degassing was also possible to synthesize Compound XXI.
- Compound XXIX was obtained by reacting 3-fluoro-4-bromoaniline with Cbz-Cl, followed by (R) -glycidyl butyrate to synthesize chiral compound B-I.
- Compound B-II, B-III, B-IV, BV, B-VI is synthesized by converting alcohol of compound BI to various derivatives of compound Y and coupling reaction with A part or bromine to pinacolborane.
- the compound of Formula 1 could be synthesized by coupling with B-VII substituted compound.
- the present invention also provides a pharmaceutical composition
- a pharmaceutical composition comprising (a) a pharmacologically effective amount of a novel oxazolidinone derivative of Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof; And (b) a pharmaceutically acceptable carrier, diluent, or excipient, or a combination thereof; provides a pharmaceutical composition for antibiotics comprising a.
- composition means a mixture of a compound of the invention with other chemical components such as diluents or carriers.
- the pharmaceutical composition facilitates administration of the compound into the organism.
- techniques for administering compounds including but not limited to oral, injection, aerosol, parenteral, and topical administration.
- Pharmaceutical compositions may also be obtained by reacting acid compounds such as hydrochloric acid, bromic acid, sulfuric acid, nitric acid, phosphoric acid, methanesulfonic acid, p-toluenesulfonic acid, salicylic acid and the like.
- a pharmacologically effective amount refers to, to some extent, alleviate or reduce one or more symptoms of the disorder being treated, or delay the onset of a clinical marker or symptom of a disease that requires prevention. It means the amount of active ingredient effective to.
- a pharmacologically effective amount can be used to determine (1) the effect of reversing the rate of disease progression, (2) the effect of inhibiting further progression of the disease to some extent, and / or (3) one or more symptoms associated with the disease. It means the quantity which has the effect of reducing a grade (preferably, removing it).
- a pharmacologically effective amount can be determined empirically by testing the compound in known in vivo and in vitro model systems for diseases in need of treatment.
- carrier is defined as a compound that facilitates the addition of a compound into a cell or tissue.
- DMSO dimethyl sulfoxide
- carrier facilitates the incorporation of many organic compounds into organisms' cells or tissues.
- diot is defined as a compound which not only stabilizes the biologically active form of the compound of interest, but also is diluted in water to dissolve the compound. Salts dissolved in buffer solutions are used as diluents in the art. A commonly used buffer solution is phosphate buffered saline, because it mimics the salt state of human solutions. Because buffer salts can control the pH of a solution at low concentrations, buffer diluents rarely modify the biological activity of a compound.
- the compounds used herein may be administered to human patients as such or as pharmaceutical compositions in combination with other active ingredients or with a suitable carrier or excipient, such as in a combination therapy.
- Techniques for formulation and administration of compounds in this application can be found in "Remington's Pharmaceutical Sciences,” Mack Publishing Co., Easton, PA, 18th edition, 1990.
- compositions of the invention can be prepared in a known manner, for example, by means of conventional mixing, dissolving, granulating, sugar-making, powdering, emulsifying, encapsulating, trapping and or lyophilizing processes. .
- compositions for use according to the present invention comprise one or more pharmacologically acceptable compositions comprising excipients or auxiliaries which facilitate the treatment of the active compounds into formulations which can be used pharmaceutically. It may also be prepared by conventional methods using a carrier. Proper formulation is dependent upon the route of administration chosen. Any of the known techniques, carriers and excipients can be used suitably and as understood in the art, for example in Remingston's Pharmaceutical Sciences described above.
- the compound of Formula 1 may be formulated into an injectable preparation, an oral preparation, and the like as desired.
- the components of the invention may be formulated in liquid solutions, preferably in pharmacologically compatible buffers such as Hank's solution, Ringer's solution, or physiological saline buffalo.
- pharmacologically compatible buffers such as Hank's solution, Ringer's solution, or physiological saline buffalo.
- noninvasive agents suitable for the barrier to pass through are used in the formulation. Such noninvasive agents are generally known in the art.
- the compounds can be formulated readily by combining the active compounds with pharmacologically acceptable carriers known in the art.
- Such carriers allow the compounds of the invention to be formulated into tablets, pills, powders, granules, sugars, capsules, liquids, gels, syrups, slurries, suspensions and the like.
- capsules, tablets, pills, powders and granules are possible, and in particular capsules and tablets are useful.
- Tablets and pills are preferably prepared with enteric agents.
- Pharmaceutical preparations for oral use may be achieved by mixing one or more compounds of the invention with one or more excipients, optionally grinding such mixtures and, if necessary, treating the mixture of granules after permeation of appropriate adjuvants.
- a tablet or sugar core can be obtained.
- suitable excipients include fillers such as lactose, sucrose, mannitol, or sorbitol; Corn starch, wheat starch, rice starch, potato starch, gelatin, gum tragakens, methyl cellulose, hydroxypropylmethyl-cellulose, sodium carboxymethyl cellulose, and / or polyvinylpyrrolidone ( Cellulose-based materials such as PVP).
- carriers such as disintergrating agents such as crosslinked polyvinyl pyrrolidone, urticaria, or salts thereof such as alginic acid or sodium alginate and lubricants such as magnesium stearate, binders and the like may be added.
- compositions that can be used orally may include soft sealing capsules made of gelatin and plasticizers such as glycols or sorbitol, as well as pushable capsules made of gelatin.
- the push-fix capsule may contain the active ingredients, as a mixture with a filler such as lactose, a binder such as starch, and / or a lubricant such as talc or magnesium stearate.
- the active compounds may be dissolved or dispersed in suitable solvents such as fatty acids, liquid paraffin, or liquid polyethylene glycols.
- stabilizers may be included. All preparations for oral administration should be in amounts suitable for such administration.
- the compounds may be formulated for parenteral administration by injection, eg, by large pill injection or continuous infusion.
- injectable formulations may be presented in unit dose form, eg, as ampoules or as multi-dos containers, with preservatives added.
- the compositions may take the form of suspensions, solutions, emulsions on oily or liquid vehicles, and may include components for formulation such as suspensions, stabilizers and / or dispersants.
- it may be in the form of a dry powder which is used as a sterile water from which the exothermic material is removed and dissolved before use.
- the compounds may also be formulated in rectal dosage compositions such as suppositories or retention enemas, including, for example, conventional suppository bases such as cocoa butter or other glycerides.
- compositions suitable for use in the present invention include compositions in which the active ingredients are contained in an amount effective to achieve their intended purpose. More specifically, a therapeutically effective amount means an amount of a compound effective to prolong the survival of the subject to be treated or to prevent, alleviate or alleviate the symptoms of a disease. Determination of a therapeutically effective amount is within the capabilities of those skilled in the art, in particular in terms of the detailed disclosure provided herein.
- the compound of formula 1 as the active ingredient is preferably contained in unit doses of about 0.1 to 1,500 mg.
- the dosage of the compound of formula 1 depends on the doctor's prescription depending on factors such as the patient's weight, age and the particular nature and severity of the disease. However, dosages required for adult treatment may be administered once to three times daily, depending on the frequency and intensity of administration, with a single dosage typically ranging from about 1 to 1500 mg. Intramuscular or intravenous administration to adults can be administered once to three times a day, separated by a single dose, with a single dosage of about 1 to 1,500 mg usually sufficient, but for some patients a higher daily Dosage may be preferred.
- compositions of the present invention may be used in other clinically useful antibacterial agents (eg, °C -lactams, macrolides, quinolone or aminoglycosides) or other anti-infective agents (eg, antifungal triazoles or amphotericins). It may be formulated with one or more known drugs selected from among them, or may be administered jointly with one or more of these known drugs.
- the compounds of the present invention may also be formulated or co-administered with bactericidal / permeable-increasing protein (BPI) products or effluent pump inhibitors to enhance activity against gram negative bacteria and bacteria that are resistant to antimicrobial agents. can do.
- BPI permeable-increasing protein
- the compounds of the present invention can also be formulated or coadministered with vitamins such as vitamin B2, vitamin B6, vitamin B12 and folic acid.
- vitamins such as vitamin B2, vitamin B6, vitamin B12 and folic acid.
- the compounds of the present invention may also be formulated or co-administered with cyclooxygenase (COX) inhibitors, in particular COX-2 inhibitors.
- COX cyclooxygenase
- the present invention also provides a method for antibiotic treatment using a novel oxazolidinone derivative represented by Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof in an effective amount. to provide.
- 2-amino-5bromopyridine (10 g, 57.80 mmol), triethylamine (17.4 mL, 124.47 mmol), ditertbutyldicarbonate (16.3 g, 74.75 mmol) and dimethylaminopyridine (0.5 g, 4.05 mmol ) was added to dichloromethane (270 mL) at 0 ° C and stirred at room temperature for 3 hours.
- the aldehyde compound thus obtained was dissolved in methanol (300 mL) and then tertbutylcarbazite (22 g, 169.0 mmol), sodium cyanoborohydride (11.6 g, 184.4 mmol) and acetic acid (11 mL, 184.4 mmol) at 0 ° C. ) Were added sequentially and stirred at room temperature for 12 hours. Acetic acid (11 mL, 184.4 mmol) was added to the reaction mixture, concentrated under reduced pressure, extracted with ethyl acetate (800 mL) and saturated aqueous sodium bicarbonate solution (500 mL), and then purified by column chromatography. Compound (25 g, 80.8. Mmol) , 53%) was obtained as a brown oil.
- the reaction was dissolved in dichloromethane (300 mL), washed sequentially with 0.5 N aqueous hydrochloric acid solution (200 mL), saturated aqueous sodium bicarbonate solution (100 mL), saturated aqueous sodium chloride solution (100 mL), and dehydrated using anhydrous sodium sulfate. Concentrated under reduced pressure to give the compound XXX (38 g, 103 mol, 99%) as a brown solid.
- reaction product was purified by column chromatography to obtain compound 1 (1.04 g, 2.28 mmol, 76%) as a gray solid.
- Example 9 The compound prepared in into a 9 (47 mg, 0.09 mmol) and dichloromethane (2 mL) and put 4M- acid (5 mL) binary dissolved in dioxane was stirred at room temperature for 2 hours and concentrated reduced pressure to give 10 (26 mg, 0.06 mmol, 62%) was obtained as a yellow solid.
- Example 18 Compound 18 (50 mg, 0.09 mmol) obtained in Example 18 was dissolved in dichloromethane (10 mL), and 4M-HCl (1 mL) was added thereto, followed by stirring for 1 hour. The reaction was concentrated under reduced pressure to give compound 19 (46 mg, 0.09 mmol, 99%) as a yellow solid.
- Example 14 and the same way, 35 compound as a white solid from the compound 32 to obtain a (90 mg, 0.12 mmol, 68 %).
- In vitro antimicrobial activity of the oxazolidinone derivatives of Examples 1 to 71 of the present invention is 90% inhibition, which is the minimum concentration of antibiotic that can inhibit the growth of bacteria by 90% compared to the drug-untreated control growth by spectroscopic measurements.
- the concentration (MIC 90 , ug / mL) was evaluated by measuring.
- MIC 90 is a CLSI standard [see Clinical and Laboratory Standards Institute Document. (2000) Methods for Dilution Antimicrobial Susceptibility Test for Bacteria that Grow Aerobically-Fifth Edition: M7-A5. CLSI, Villanova, PA] was measured by the Broth microdilution method.
- Test substance (oxazolidinone derivative compounds 1 to 71 according to the present invention synthesized in Examples 1 to 71) was dissolved in DMSO at a concentration of 10240 ug / mL and diluted twice by fold to sterilized tertiary distilled water. Diluted 20fold.
- the final concentration was from 128 ug / mL up to 0.063 ug / mL, and the concentration of DMSO used as excipient was 2.5% (V / V).
- the antibacterial activity was compared using Linefide (Formula B) of Pfizer, and the results are shown in Table 1 below.
- the oxazolidinone derivatives of the present invention are effective against Gram-positive bacteria (MRSA, VRE, etc.), which are resistant to conventional antibiotics at much lower concentrations than the control agent linezolid. It can be seen that it is also very effective against resistant bacteria.
- the compounds 3 , 11 and 54 show very high antibacterial activity against linezolide resistant Enterococcus faecalis and pasium. Shows that it can be used.
- the oxazolidinone derivative of the present invention is an antibiotic having a broad spectrum against Gram-positive bacteria and can be usefully used as a therapeutic agent for infection by resistant strains such as MRSA and VRE and in particular by linezolide resistant bacteria. have.
- the novel oxazolidinone derivatives of the present invention have a broad antimicrobial spectrum against resistant bacteria including MRSA and VRE, and particularly show high activity against linezolide resistant bacteria, and thus are useful as second-generation oxazolidinone-based antibiotics.
- the compounds of the present invention contain a cyclic amidrazon or cyclic amidoxime group to form a salt, so that the solubility in water is higher than the known compounds, it is easy to develop oral or injection.
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Abstract
Description
Claims (7)
- 하기 화학식 1로 표시되는 신규한 옥사졸리디논 유도체, 이의 프로드럭, 이의 수화물, 이의 용매화물, 이의 이성질체 또는 이들의 약제학적으로 허용되는 염:상기 식에서,R은 하기 구조들에서 선택되는 헤테로 고리이고:R1은 수소, C1-C6 알킬 또는 C3-C6 시클로알킬이며;R2는 수소, C1-C6 알킬 또는 (CH2)mC(=O)R21 이며;여기서, R21은 수소, (CH2)nNHR211, CH2OH 또는 CH(OH)CH2OH 이며, 여기서, R211은 수소 또는 C1-C6 알킬이며;m 및 n은 서로 독립적으로 0 내지 3의 정수이며;여기서, R3는 수소, C1-C6 알킬, -C(=O)R31 또는 하기 구조에서 선택되는 헤테로 방향족 고리이며;여기서, R31은 수소, C1-C6 알킬, C3-C6 시클로로알킬 또는 O-(C1-C6) 알킬 이다.
- (a) 약리학적 유효량의 제 1 항 내지 제 5 항 중 어느 하나에 따른 신규한 옥사졸리디논 유도체, 이의 프로드럭, 이의 수화물, 이의 용매화물, 이의 이성질체 또는 이들의 약제학적으로 허용되는 염; 및(b) 약제학적으로 허용되는 담체, 희석제, 또는 부형제, 또는 이들의 조합:을 포함하는 것으로 구성된 것을 특징으로 하는 항생제용 의약 조성물.
- 제 1 항에 따른 화학식 1로 표시되는 신규한 옥사졸리디논 유도체, 이의 프로드럭, 이의 수화물, 이의 용매화물, 이의 이성질체 또는 이들의 약제학적으로 허용되는 염을 유효량으로 사용하여, 항생 처리를 하는 방법.
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EP18167465.6A EP3372598A1 (en) | 2011-03-30 | 2012-03-29 | Novel oxazolidinone derivative and pharmaceutical composition including the same |
JP2014502469A JP6072764B2 (ja) | 2011-03-30 | 2012-03-29 | 新規なオキサゾリジノン誘導体およびそれを含む医薬組成物 |
US14/008,702 US8846669B2 (en) | 2011-03-30 | 2012-03-29 | Oxazolidinone derivative and medical composition containing same |
BR112013024497-6A BR112013024497A2 (ko) | 2011-03-30 | 2012-03-29 | Novel oxazolidinone derivatives and pharmaceutical compositions containing them |
MX2013011272A MX337409B (es) | 2011-03-30 | 2012-03-29 | Derivado de oxazolidinona novedoso y composicion farmaceutica que incluye el mismo. |
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KR100872059B1 (ko) * | 2007-02-21 | 2008-12-05 | 주식회사 레고켐 바이오사이언스 | 아미독심 또는 하이드록사마이드 기를 가지는 신규한옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
KR101023174B1 (ko) * | 2008-09-24 | 2011-03-18 | 주식회사 레고켐 바이오사이언스 | 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
KR101037051B1 (ko) * | 2009-07-08 | 2011-05-26 | 주식회사 레고켐 바이오사이언스 | (s)-5-클로로-n-((3-(4-(5,6-다이하이드로-4h-1,2,4-옥사다이아진-3-일)페닐)-2-옥소옥사졸리딘-5-일)메틸)싸이오펜-2-카르복사미드 유도체의 제조방법 |
-
2011
- 2011-03-30 KR KR1020110028559A patent/KR101653570B1/ko active IP Right Grant
-
2012
- 2012-03-29 EP EP18167465.6A patent/EP3372598A1/en not_active Withdrawn
- 2012-03-29 CN CN201280016771.9A patent/CN103476772B/zh not_active Expired - Fee Related
- 2012-03-29 EP EP12764499.5A patent/EP2692727A4/en not_active Ceased
- 2012-03-29 US US14/008,702 patent/US8846669B2/en not_active Expired - Fee Related
- 2012-03-29 JP JP2014502469A patent/JP6072764B2/ja not_active Expired - Fee Related
- 2012-03-29 MX MX2013011272A patent/MX337409B/es active IP Right Grant
- 2012-03-29 RU RU2013143800A patent/RU2617408C2/ru not_active IP Right Cessation
- 2012-03-29 AU AU2012237067A patent/AU2012237067B2/en not_active Ceased
- 2012-03-29 CA CA2831799A patent/CA2831799A1/en not_active Abandoned
- 2012-03-29 BR BR112013024497-6A patent/BR112013024497A2/ko not_active IP Right Cessation
- 2012-03-29 WO PCT/KR2012/002314 patent/WO2012134188A2/ko active Application Filing
-
2013
- 2013-09-26 ZA ZA2013/07216A patent/ZA201307216B/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0127902A2 (en) | 1983-06-07 | 1984-12-12 | E.I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
KR20080093712A (ko) | 2007-04-18 | 2008-10-22 | 주식회사 하이닉스반도체 | 트리밍 테스트모드 및 노말 테스트모드를 갖는반도체메모리소자 |
Non-Patent Citations (8)
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"Remington's Pharmaceutical Sciences, 18th edition,", 1990, MACK PUBLISHING CO. |
H. BUNDGAARD ET AL., JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 77, 1988, pages 285 |
H. BUNDGAARD, ADVANCED DRUG DELIVERY REVIEWS, vol. 8, 1992, pages 1 - 38 |
H. BUNDGAARD,: "Design of Prodrugs", 1985, ELSEVIER |
H. BUNDGAARD: "A Textbook of Drug Design and Development", 1991, article "Design and Application of Prodrugs", pages: 113 - 191 |
K. WIDDER, ET AL.: "Methods in Enzymology", vol. 42, 1985, ACADEMIC PRESS, pages: 309 - 396 |
N. KAKEYA ET AL., CHEM PHARM BULL, vol. 32, 1984, pages 692 |
See also references of EP2692727A4 |
Also Published As
Publication number | Publication date |
---|---|
BR112013024497A2 (ko) | 2018-06-26 |
WO2012134188A3 (ko) | 2013-01-10 |
KR101653570B1 (ko) | 2016-09-02 |
MX2013011272A (es) | 2014-03-21 |
RU2013143800A (ru) | 2015-05-10 |
EP2692727A4 (en) | 2014-10-15 |
MX337409B (es) | 2016-03-02 |
EP3372598A1 (en) | 2018-09-12 |
AU2012237067A1 (en) | 2013-10-03 |
CA2831799A1 (en) | 2012-10-04 |
AU2012237067B2 (en) | 2016-07-28 |
KR20120110600A (ko) | 2012-10-10 |
ZA201307216B (en) | 2014-12-23 |
CN103476772B (zh) | 2016-03-30 |
US20140179691A1 (en) | 2014-06-26 |
US8846669B2 (en) | 2014-09-30 |
JP6072764B2 (ja) | 2017-02-01 |
RU2617408C2 (ru) | 2017-04-25 |
EP2692727A2 (en) | 2014-02-05 |
JP2014510751A (ja) | 2014-05-01 |
CN103476772A (zh) | 2013-12-25 |
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