WO2012063947A1 - 脂質ペプチド型ゲル化剤と高分子化合物とを含有するゲルシート - Google Patents
脂質ペプチド型ゲル化剤と高分子化合物とを含有するゲルシート Download PDFInfo
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- 239000009538 yokuinin Substances 0.000 description 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
- 229960001028 zanamivir Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229940105125 zinc myristate Drugs 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- ZNVKGUVDRSSWHV-UHFFFAOYSA-L zinc;4-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=C(S([O-])(=O)=O)C=C1.OC1=CC=C(S([O-])(=O)=O)C=C1 ZNVKGUVDRSSWHV-UHFFFAOYSA-L 0.000 description 1
- GBFLQPIIIRJQLU-UHFFFAOYSA-L zinc;tetradecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O GBFLQPIIIRJQLU-UHFFFAOYSA-L 0.000 description 1
- 239000001243 zingiber officinale rosc. root absolute Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Images
Classifications
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0095—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0052—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
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- A61K2800/10—General cosmetic use
Definitions
- the present invention relates to a gel sheet, and more particularly to a gel sheet containing a low molecular weight lipid peptide type gelling agent and a polymer compound.
- Gels especially sheet gels in which hydrogels are formed into sheets, carry active ingredients such as packs and patches, skin permeation components and anti-inflammatory analgesic components used in cosmetics and medical fields for beauty and skin treatments. It is used for adhesive tapes for living bodies, wound dressings, etc. for the purpose of body protection, wound protection and drug immobilization.
- a sheet-like gel is generally used as a water-containing gel layer formed on a sheet-like support, and a nonwoven fabric made of polyester or polypropylene is frequently used as the support (Patent Document 1). ).
- the base material of the hydrogel natural products, organic / inorganic composite hydrogels, and synthetic polymers are generally used.
- natural gel bases polysaccharides such as hyaluronic acid, xanthan gum, gellan gum, agarose, carrageenan and gum arabic are known.
- Gels using natural product-based gel equipment such as these natural polysaccharides have the problems of low strength and poor flexibility.
- polymethyl (meth) acrylate as a gel reinforcing agent.
- Methacrylic resin powder having a functional group an acrylic aqueous solution having a functional group, a method of adding polyethylene glycol, etc.
- Patent Document 2 a method of chemically cross-linking to improve strength
- Patent 2 Document 3 a method of chemically cross-linking to improve strength
- Patent 2 Document 3 organic / inorganic composite hydrogels (nanocomposite gels) using a layered exfoliated clay as an ultra-multifunctional cross-linking agent are subjected to pressure treatment, decompression treatment and stretching treatment under drying and heat treatment, resulting in high strength and high strength.
- Patent Document 4 a problem that the manufacturing process is complicated is pointed out.
- a synthetic polymer gel is a gel in which polymer chains are crosslinked by irradiation with an organic crosslinking agent, ⁇ ray or electron beam.
- PVA polyvinyl alcohol
- Hydrogels are expected as biocompatible materials such as wound dressings.
- a method such as a PVA hydrogel laminate (Patent Document 5) in which an aqueous solution of PVA is dried and heat-treated and irradiated with radiation to increase the gel strength. Both have complicated processes for industrialization.
- Non-Patent Document 1 A complicated production method and a production method (Non-Patent Document 1) in which PVA is crosslinked with glutaraldehyde are known.
- the manufacturing procedure is easy because the procedure is complicated and there is no danger of monomer (glutaraldehyde) contamination, and there is a risk of irritating the skin and wounds when used in cosmetics and external preparations.
- a gel using a highly safe material is desired.
- carboxyvinyl polymers or carboxyvinyl polymer derivatives are frequently used for gel formation due to ease of manufacture and flexibility, but skin irritation due to a neutralizing agent necessary to gel this carboxyvinyl polymer. There is also a need for improvements in performance and stability.
- Non-patent Document 2 Non-patent Document 3
- Most of them are amphiphilic compounds in which a long-chain alkyl group that is a hydrophobic part and a hydrophilic part are combined.
- the hydrophilic part is an amino acid (Non-patent Document 4), a peptide (Patent Document 6, Examples thereof include Patent Document 7), monopolysaccharide (Non-Patent Document 5, Non-Patent Document 6, Non-Patent Document 7) or Polyol (Non-Patent Document 8).
- a low molecular gelling agent Non-patent Document 9 utilizing the fact that a peptide composed of valine easily takes a ⁇ -sheet structure has also been proposed.
- the sheet-like hydrogel is expected to be applied in the cosmetics and medical fields, but is required to be made of a material that is highly biocompatible and safe, such as not using a crosslinking agent harmful to humans. Yes. Furthermore, in actual use, it is required to have excellent usability such as strength, flexibility and adhesion to the skin. However, the conventionally proposed sheet-like hydrogel has not been satisfactory in all of these requirements. In addition, although several gelling agents composed of low molecular weight compounds and hydrogels based on the gels have been proposed as the biocompatible and highly safe materials described above, self-organization using gelling agents composed of low molecular weight compounds has been proposed. There has been no report of a functional sheet-like hydrogel formed using the structure.
- an object of the present invention is to provide a gel sheet having excellent usability when applied to human skin.
- a gel sheet comprising a low-molecular-weight lipid peptide or a pharmaceutically usable salt thereof, a lipid peptide-type gelling agent, and a polymer compound
- the present inventors have found that it is excellent in biocompatibility and safety, has sufficient strength and flexibility, and has excellent usability when applied to the skin.
- the present inventors have high alcohol irritation to the skin, and should be avoided as much as possible.
- the inventors have found that a gel sheet having sufficient strength and flexibility can be obtained by adding lactate without using alcohol as a solvent or the like, thereby completing the present invention.
- the present invention provides, as a first aspect, a gel sheet comprising a lipid peptide type gelling agent comprising a low molecular lipid peptide having a molecular weight of 1,000 or less or a pharmaceutically usable salt thereof, and a polymer compound.
- the present invention relates to a gel sheet comprising the polymer compound in an amount of more than 1% (w / w) and less than 50% (w / w) with respect to the total mass of the gel sheet.
- the present invention relates to the gel sheet according to the first aspect, wherein the polymer compound is contained in an amount of 2% (w / w) to 20% (w / w) with respect to the total mass of the gel sheet.
- the present invention relates to the gel sheet according to the first aspect, wherein the polymer compound is selected from a linear polymer compound having a hydroxy group or a polysaccharide.
- the present invention relates to the gel sheet according to the third aspect, wherein the polymer compound is polyvinyl alcohol, gum arabic or gelatin.
- the present invention relates to the gel sheet according to the first aspect, wherein the low molecular weight lipid peptide is a lipid peptide represented by the following formula (1) or a pharmaceutically usable salt thereof.
- R 1 represents an aliphatic group having 9 to 23 carbon atoms
- R 2 and R 3 each independently represents a hydrogen atom, a methyl group, an ethyl group, or a branched group having 1 to 3 carbon atoms.
- R 2 represents a hydrogen atom, a methyl group, an i-propyl group, an i-butyl group, or a sec-butyl group.
- the present invention relates to the gel sheet according to the fifth aspect, wherein R 3 represents a 4-aminobutyl group, a 4-imidazolmethyl group, a carbamoylmethyl group, a 2-carbamoylethyl group, or a 3-indolemethyl group.
- R 1 represents an aliphatic group having 13 to 17 carbon atoms
- R 2 represents a hydrogen atom, a methyl group, or an i-propyl group
- R 3 represents 4- The gel sheet according to the fifth aspect, which represents an aminobutyl group, a 4-imidazolmethyl group, or a 3-methylindole group.
- any one of the first aspect to the ninth aspect includes water, alcohol, polyhydric alcohol, hydrophilic organic solvent, hydrophobic organic solvent, or a mixed solution composed of two or more of these. It relates to the gel sheet described in the item.
- the gel sheet according to the tenth aspect which includes water or a mixed solution composed of water and one or more selected from the group consisting of alcohol, polyhydric alcohol, oil and fat, silicone oil, and ester solvent. About.
- the gel sheet according to the eleventh aspect comprising a mixed solution composed of one or more selected from the group consisting of propylene glycol esters.
- one or more polyhydric alcohols selected from the group consisting of glycerin, propylene glycol, polyethylene glycol and 1,3-butanediol, or at least one of the polyhydric alcohols, ethanol,
- a mixed solution consisting of one or more selected from the group consisting of 2-propanol, oleoyl alcohol, phenoxy alcohol, aqua jojoba oil, castor oil, olive oil, silicone oil, and propylene glycol alginate This relates to the gel sheet.
- the gel sheet as described in a 10th viewpoint including the solution containing water and 1 type of lactate selected from the group which consists of potassium lactate, sodium lactate, and calcium lactate.
- the present invention relates to the gel sheet according to the fifteenth aspect, further including one or more polyhydric alcohols selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, and 1,3-butylene glycol.
- the laminated body which has a nonwoven fabric, a film, or a foam as a support body piled up on the gel sheet as described in any one of the 1st viewpoint thru
- the present invention relates to the laminate according to the seventeenth aspect, wherein the support is selected from polyurethane, PVA, polypropylene, cellulose, or a laminate support thereof.
- the support is selected from polyurethane, PVA, polypropylene, cellulose, or a laminate support thereof.
- the gel sheet as described in any one of the 1st viewpoint thru
- the gel sheet as described in any one of the 1st viewpoint thru
- a 22nd viewpoint it is related with the laminated body as described in any one of the 17th viewpoint thru
- a 23rd viewpoint it is related with the laminated body as described in any one of the 17th viewpoint thru
- the gel sheet of the present invention is easily obtained by a low molecular weight lipid peptide type gelling agent, and does not require a cross-linking agent required at the time of conventional gel formation, so it has excellent biocompatibility and safety.
- the gel sheet of the present invention is a gel sheet that can be easily obtained in the form of a sheet by mixing each component, heating, dissolving, and allowing to stand, and without requiring a complicated procedure that has been conventionally required.
- the gel sheet of the present invention has a high strength and a high elasticity in addition to the properties as a conventional gel by comprising a solvent and particularly a polymer compound in addition to the lipid peptide type gelling agent. It can be set as a gel sheet.
- the gel sheet of this invention can reduce the content of a high molecular compound with the said lipid peptide type gelatinizer, As a result, the content of solvents, such as water, can be increased. For this reason, when the gel sheet of the present invention is brought into contact with human skin, it can reduce the feeling of stickiness and squeakiness due to the increase in the amount of the polymer compound, and the touch, moisturizing feeling, cool feeling, etc. Usability can be improved.
- the gel sheet of the present invention can form a strong sheet by immersing it in alcohol (ethanol or the like) after the gel sheet is formed, and at the same time can be sterilized and sterilized. Further, the sheet can be formed by dipping in a lactate solution instead of dipping in alcohol.
- the gel sheet of this invention has the effect that a hydrophilic and hydrophobic chemical
- FIG. 1 is a photograph showing a state after dropping the gel obtained in Example 1 onto a glass petri dish and allowing it to stand overnight.
- FIG. 2 is an enlarged photograph of a gel sheet containing N-palmitoyl-Gly-His and gum arabic after standing overnight.
- FIG. 3 is an enlarged photograph of a gel sheet containing N-palmitoyl-Gly-His and PVA after standing overnight.
- FIG. 4 is a photograph of a gel sheet containing N-palmitoyl-Gly-His and gum arabic observed with an optical microscope after standing overnight.
- FIG. 5 is a photograph of the gel sheet containing N-palmitoyl-Gly-His and PVA observed with an optical microscope after standing overnight.
- FIG. 1 is a photograph showing a state after dropping the gel obtained in Example 1 onto a glass petri dish and allowing it to stand overnight.
- FIG. 2 is an enlarged photograph of a gel sheet containing N-palmitoyl-Gly
- FIG. 6 is a photograph showing the gel obtained in the Reference Example in the form of a fiber, and the forms during dehydration and water absorption.
- FIG. 7 is a conceptual diagram of self-assembly and gelation of a lipid peptide type gelling agent in water, alcohol, polyhydric alcohol, and hydrophilic organic solvent.
- FIG. 8 is a conceptual diagram of self-assembly and gelation of a lipid peptide type gelling agent in a hydrophobic organic solvent.
- FIG. 9 is a conceptual diagram of self-assembly (lamellar secondary assembly) of lipid peptide type gelling agents in alcohol, polyhydric alcohol, and hydrophilic organic solvent.
- FIG. 10 is a graph showing the breaking stress and the breaking deformation distance of the ethanol-immersed sheet obtained in Example 14 and the post-ethanol-immersed water replacement sheet obtained in Example 15.
- FIG. 11 is a graph showing the breaking stress and breaking deformation distance of the methanol-immersed sheet obtained in Example 18 and the post-methanol-immersed water replacement sheet obtained in Example 19.
- 12 is an observation photograph (FIG. 12 (a) ⁇ 350 times, FIG. 12 (b) ⁇ 1000 times) of the methanol-immersed sheet obtained in Example 18 with an energy dispersive X-ray analyzer-attached scanning electron microscope. .
- FIG. 12 is an observation photograph (FIG. 12 (a) ⁇ 350 times, FIG. 12 (b) ⁇ 1000 times) of the methanol-immersed sheet obtained in Example 18 with an energy dispersive X-ray analyzer-attached scanning electron microscope. .
- FIG. 12 is an observation photograph (FIG. 12 (a) ⁇ 350 times, FIG. 12 (b)
- FIG. 13 is a graph which shows the wound area (%) with respect to the elapsed days (horizontal axis) after sheet
- FIG. 14 is a graph showing 50% wound healing average days for the healing effect of the four types of dressing.
- FIG. 15 is a photograph of normal mice observed with a normal skin HE stained microscope.
- FIG. 16 is a photograph taken by a wound wound skin HE staining microscope 4 days after wound / covering treatment of a wound model mouse (coated substrate FIG. 16 (A): N-palmitoyl-Gly-His frozen gel / thawed gel sheet, FIG. 16B: PVA gel freezing / thawing gel, FIG. 16C: hydrocolloid material, FIG.
- FIG. 17 shows the red blood cell trapping effect of a mixed sample of N-palmitoyl-Gly-His gel and guinea pig stored blood (FIG. 17A) and a mixed sample of 10% CMC and guinea pig stored blood (FIG. 17B). It is an observation photograph by an optical microscope.
- FIG. 18 is an observation photograph of a mixed sample of N-palmitoyl-Gly-His gel and guinea pig stored blood, using a scanning electron microscope with an energy dispersive X-ray analyzer.
- the present invention relates to a gel sheet containing a lipid peptide type gelling agent and a polymer compound.
- a gel sheet containing a lipid peptide type gelling agent and a polymer compound.
- the gel sheet of the present invention is characterized by containing at least one lipid peptide type gelling agent comprising a low molecular weight lipid peptide or a pharmaceutically usable salt thereof.
- the lipid peptide preferably has a molecular weight of 1,000 or less.
- Examples of the low molecular weight lipid peptide include a lipid peptide having a lipid part and a peptide part represented by the following formula (1) or a pharmaceutically usable salt thereof.
- R 1 represents an aliphatic group having 9 to 23 carbon atoms, and preferably an aliphatic group having 13 to 17 carbon atoms.
- Examples of the lipid moiety composed of R 1 and the adjacent carbonyl group include a decoyl group, a dodecyl group, an undecoil machine, a lauroyl group, a dodecylcarbonyl group, a myristoyl group, a tetradecylcarbonyl group, a palmitoyl group, a margaroyl group, and an oleoyl.
- Group elidoyl group, linoleoyl group, stearoyl group, baccenoyl group, octadecylcarbonyl group, arachidonoyl group, icosanoyl group, behenoyl group, ercoyl group, docosylcarbonyl group, lignocelloyl group, nerbonoyl group, etc.
- Examples include myristoyl group, tetradecylcarbonyl group, palmitoyl group, margaroyl group, oleoyl group, eridoyl group, linoleoyl group, stearoyl group, and vaccenoyl group.
- R 2 and R 3 each independently represent a hydrogen atom, a methyl group, an ethyl group, or an alkyl having 3 to 7 carbon atoms which may have a branched chain having 1 to 3 carbon atoms.
- X is composed of an amino group, a guanidino group, a carbamoyl group, a 5-membered cyclic group or a 6-membered cyclic group which may have 1 to 3 nitrogen atoms, or a 5-membered ring and a 6-membered ring Represents a fused heterocyclic group.
- R 2 represents a hydrogen atom, a methyl group, an ethyl group, or an alkyl group having 3 to 7 carbon atoms which may have a branched chain having 1 to 3 carbon atoms.
- R 2 is preferably a hydrogen atom, a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an n-butyl group, an i-butyl group, a sec-butyl group or a tert-butyl group. More preferably, they are a hydrogen atom, a methyl group, an i-propyl group, an i-butyl group, or a sec-butyl group, and even more preferably a hydrogen atom.
- R 3 represents a hydrogen atom, a methyl group, or a — (CH 2 ) nX group, n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a —CONH 2 group, or a nitrogen atom
- X represents an amino group, a guanidino group, a —CONH 2 group, or a nitrogen atom
- R 3 represents a hydrogen atom, a methyl group, or a — (CH 2 ) nX group, n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a —CONH 2 group, or a nitrogen atom Represents a 5-membered ring group, a 6-membered ring group, or a condensed ring group composed of a 5-membered ring and a 6-membered ring.
- X is preferably an amino group, guanidino group, carbamoyl group, imidazole group, pyrazole group or indole group.
- the — (CH 2 ) nX group representing R 3 is preferably an aminomethyl group, 2-aminoethyl group, 3-aminopropyl group, 4-aminobutyl group, carbamoylmethyl group, 2-carbamoyl group.
- the number m of repeating peptide structures is an integer of 1 to 3.
- a lipid peptide particularly suitable as a lipid peptide-type gelling agent is a compound formed from the following lipid part and peptide part.
- amino acids asparagine (Asn), alanine (Ala), glutamine (Gln), glycine (Gly), valine (Val), histidine (His), lysine (Lys), and leucine (Leu) are represented.
- Myristoyl-Gly-His Myristoyl-Gly-Lys, Myristoyl-Gly-Asn, Myristoyl-Gly-Gln, Myristoyl-Gly-Gly-His, Myristoyl-Gly-Gly-Lys, Myristoyl-Gly-Gly-Asn, -Gly-Gly-Gln, Myristoyl-Gly-Gly-Gly-His, Myristoyl-Gly-Gly-Gly-Lys, Myristoyl-Gly-Gly-Gly-Asn, Myristoyl-Gly-Gly-Gly-Gln, Myristoyl-Aly -His, Myristoyl-Ala-Lys, Myristoyl-Ala-Asn, Myristoyl-Ala-Gln, Myristoyl-Ala-Gln, Myristoyl-Ala-Gln, Myristoyl-Ala-A
- myristoyl-Gly-His myristoyl-Gly-Gly-His, myristoyl-Gly-Gly-His, palmitoyl-Gly-His, palmitoyl-Gly-Gly-His, palmitoyl-Gly-Gly-Gly -His, stearoyl-Gly-His, stearoyl-Gly-Gly-His, stearoyl-Gly-Gly-His.
- examples of usable low molecular weight lipid peptides include a lipid part and an amino acid part or peptide part shown below. Mention may be made of lipid peptides.
- the abbreviations for amino acids are as described above.
- Myristoyl-His Myristoyl-Lys, Myristoyl-Asn, Myristoyl-Gln, Myristoyl-Gly-Gly-Gly-His, Myristoyl-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly Asn, Myristoyl-Gly-Gly-Gly-Gly-Gly-Gln, Myristoyl-Ala-Ala-Ala-His, Myristoyl-Ala-Ala-Ala-Alys, Myristoyl-Ala-Ala-Ala-Asn Myristoyl-Ala-Ala-Ala-Gln, Myristoyl-Val-Val-
- myristoyl-HiS myristoyl-Gly-Gly-Gly-Gly-His
- palmitoyl-His palmitoyl-Gly-Gly-Gly-Gly-His
- stearoyl-His stearoyl-Gly-Gly-Gly- Examples
- Gly-Gly-His examples include Gly-Gly-His.
- polymer compound examples include guar gum, locust bean gum, queensseed, carrageenan, galactan, gum arabic, tara gum, tamarind, far celeran, karaya gum, trooaoi, cara gum, tragacanth gum, pectin, pectinic acid and Salt such as sodium salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, Chitin, chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose Cellulose, hydroxymethylpropylcellulose, hydroxypropylcellulose, carb
- the polymer compound is included in an amount of more than 1% (w / w) and less than 50% (w / w) with respect to the total mass of the gel sheet.
- the polymer compound is in an amount of 2% (w / w) to 20% (w / w), more preferably 5% (w / w) to 10% (w / w) based on the total mass of the gel sheet. w / w).
- the concentration of the lipid peptide type gelling agent is not particularly limited as long as it is a concentration capable of forming a gel sheet, but preferably 0.0001 to 50% (w / W), more preferably 0.0001 to 20% (w / w), still more preferably 0.1 to 5% (w / w). If the blending amount is less than 0.0001% (w / w), the effect as a gelling agent may not occur. If the blending amount is more than 50% (w / w), stability during long-term storage cannot be obtained. There is a case. By setting the blending amount to 0.0001 to 50% (w / w), it is possible to impart sensory characteristics such as moisturizing feeling (moist feeling) and cooling feeling (cool feeling) to the obtained gel sheet.
- the gel sheet of the present invention comprises a solvent other than the lipid peptide type gelling agent and the polymer compound, that is, water, alcohol, polyhydric alcohol, hydrophilic organic solvent, hydrophobic organic solvent, or two or more thereof. Contains mixed solution.
- Preferred examples of the water include purified water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkali ion water, electrolytic acid ion water, ion water, and cluster water.
- the alcohol is a monohydric alcohol, for example, an alcohol having 1 to 6 carbon atoms that dissolves in water at an arbitrary ratio, specifically methanol, ethanol, 2-propanol, i-butanol, etc., and higher alcohols.
- Specific examples include oleyl alcohol and phenoxy alcohol. However, it is not limited to these.
- the polyhydric alcohol is a dihydric or higher alcohol, such as propylene glycol, 1,3-butanediol, 2-ethyl-1,3-hexanediol, glycerin, isopentyldiol, ethylhexanediol, erythrulose, ozonized glycerin.
- Caprylyl glycol glycol, glycol, glycol (having 15 to 18 carbon atoms), glycol (having 20 to 30 carbon atoms), diethylene glycol, diglycerin, dithiaoctanediol, dipropylene glycol (DPG), thioglycerin, 1 , 10-decanediol, decylene glycol, triethylene glycol, chylmethylgydroxymethylcyclohexanol, phytanetriol, phenoxypropanediol, 1,2-butanediol, 2,3-butanediol, Le ethyl propanediol, 1,2-hexanediol, hexylene glycol, pentylene glycol, methyl propane diol, menthane diols, lauryl glycol, polyethylene glycol and polypropylene glycol, and the like.
- the hydrophilic organic solvent means an organic solvent that dissolves at an arbitrary ratio in water excluding alcohol and polyhydric alcohol. Examples include acetone, dioxane, ethyl acetate, aqua jojoba oil, and the like.
- the hydrophobic organic solvent means an organic solvent that is not freely soluble in water except alcohol.
- oils and fats, silicone oils, ester solvents examples include castor oil and olive oil.
- examples of the silicone oil include dimethyl silicone oil and methylphenyl silicone oil.
- Examples of the ester solvent include propylene glycol alginate, ethyl acetate, diheptylundecyl adipate, lanolin acetate, isostearyl glyceryl, octyldodecyl isostearate, and the like.
- a mixed solution comprising at least one selected from the group consisting of polyhydric alcohols and at least one selected from the group consisting of alcohols, fats and oils, silicone oils, and ester solvents is preferred.
- Particularly preferred is water or a solution in which alcohol or polyhydric alcohol is dissolved in water.
- alcohol such as ethanol
- a solvent contained in the gel sheet of the present invention sufficient strength is obtained by using a solution containing one kind of lactate selected from the group consisting of potassium lactate, sodium lactate and calcium lactate with respect to the water. And a flexible gel sheet can be obtained.
- the gel sheet of the present invention includes additives such as physiologically active substances and functional substances that are generally blended in cosmetics, pharmaceuticals or foods as required, such as oily bases, moisturizers, feel improvers, interfaces, and the like.
- Activator solvent, propellant, antioxidant, stabilizer, reducing agent, oxidizing agent, preservative, antibacterial agent, bactericidal agent, chelating agent, pH adjuster, acid, alkali, powder, inorganic salt, UV absorber , Whitening agent, vitamins and derivatives thereof, hair growth agent, blood circulation promoter, stimulant, hormones, anti-wrinkle agent, anti-aging agent, squeeze agent, cooling sensation agent, warming sensation agent, wound healing promoter, irritation Relief agent, analgesic agent, cell activator, plant / animal / microbe extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid, fragrance, pigment, colorant, dye, pigment Anti-inflammatory agent, anti-inflammatory agent, anti-asthma, anti-chronic obstructive pulmonary disease, anti-allergic , Immunomodulators, anti-infective agents and antifungal agents.
- additive components include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, seraalkyl alcohol, batyl.
- Higher (polyhydric) alcohols such as alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimer diol; aralkyl alcohols such as benzyl alcohol and their derivatives; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid , Behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahe Higher fatty acids such as saenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long chain branched fatty acid, dimer acid, hydrogenated dimer acid, and aluminum salts, calcium salts, magnesium salts, zinc salts thereof, Metal soaps such as potassium salts and sodium salt
- humectants and feel improvers examples include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc.
- Ethoxydiglycol ethylene glycol monoethyl ether
- ethylene glycol monobutyl ether diethylene glycol dibutyl
- Water-soluble esters such as polyglyceryl-10 and tetradecandioic acid polyglyceryl-10; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol; glucose, fructose, galactose Mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins ( ⁇ -, ⁇ -, ⁇ -cyclodextrin, and maltosylation, Modified cyclodextrins such as hydroxyalkylation), ⁇ -glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycoge Sugars and
- the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant.
- preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate esters such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; Polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine tri Acyl N-methyl amino acid salts such as ethanolamine and sodium methylalanine sodium, la
- Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxy diglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as diacetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; glycol esters such as dieth
- Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned.
- Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like.
- Preferred examples of the oxidizing agent include hydrogen peroxide water, ammonium persulfate, sodium bromate, percarbonate, and the like.
- antiseptics, antibacterial agents, and bactericides include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben, and butylparaben and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-pentanediol, 1, 1,2-diols such as 2-hexanediol; isothiazoline derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan; Acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexach
- chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable.
- edetate ethylenediaminetetraacetate
- HEDTA3Na EDTA3Na
- EDTA4Na hydroxyethylethylenediaminetriacetate
- pentetate diethylenetriaminepent
- pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, potassium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid , Monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine Sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.
- powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, saucite, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, and silicic acid.
- Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.
- sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt
- potassium chloride aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chlor
- ultraviolet absorbers examples include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester.
- Benzoic acid ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid systems such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate External line absorbent: octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropy
- whitening agents include hydroquinone glycosides such as arbutin and ⁇ -arbutin and their esters; ascorbic acid phosphates such as ascorbic acid, sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract,
- Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; ⁇ , Vitamin E such as ⁇ , ⁇ , and ⁇ -tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, Ascorbic acid fatty acid esters
- Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, ⁇ -oryzanol, cephalanthin, vitamin E and derivatives such as tocopherol / nicotinic acid tocopherol, ⁇ -oryzanol, nicotinic acid and nicotinamide / benzyl nicotinate Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitive element 301, photosensitive element 401, capronium chloride, pentadecanoic acid monoglyceride Flavonol derivatives, stigmasterol or stigmasteranol and
- hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like.
- retinols such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, ⁇ - or such as hydroxycapric acid, long chain ⁇ -hydroxy fatty acid, long chain ⁇ -hydroxy fatty acid cholesteryl ⁇ -hydroxy acids and derivatives thereof; ⁇ -aminobutyric acid, ⁇ -amino- ⁇ -hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, ⁇ -lipoic acid, platinum nanocolloid,
- Antioxidants and reactive oxygen scavengers include catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides Derivatives such as hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; and fragrance substances such as menthol and cedrol and their derivatives; Capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; complexes of physiologically active substances and cyclodextrins are preferred.
- Plant / animal / microbe extracts include iris extract, ashitaba extract, asunaro extract, asparagus extract, avocado extract, achacha extract, almond extract,retea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, water content Silk, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cy
- antipruritic agents examples include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like.
- exfoliating / dissolving agent examples include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like.
- antiperspirants examples include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate, and the like.
- Examples of the refreshing agent include menthol and methyl salicylate.
- astringents include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium, and tannic acid.
- Enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like.
- Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.
- Anti-inflammatory agents and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, ketoprofen, fernavik, ibuprofen, diclofenac, loxoprofen, celecoxib, infliximab, zinc oxide, etanercept Preferred examples include hydrocortisone, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and persimmon leaf extract.
- Anti-asthma, anti-chronic obstructive pulmonary disease, anti-allergy, immunomodulators include aminophylline, theophylline, steroids (fluticasone, beclomethasone, etc.), leukotriene antagonists, thromboxane inhibitors, intal, ⁇ 2-stimulant (Formoterol, salmeterol, albuterol, tulobuterol, clenbuterol, epinephrine, etc.), tiotropium, ipratropium, dextromethorphan, dimemorphan, bromhexine, tranilast, ketotifen, azelastine, cetirizine, chlorpheniramine, polyquitolsine, Preferred examples include cytokine regulators, interferons, omalizumab, and protein / antibody preparations.
- anti-infective and antifungal agents include oseltamivir, zanamivir, and itraconazole.
- the gel sheet of the present invention thus obtained includes skin care products, cosmetic base materials, beauty base materials, clean products, external medicines, pharmaceutical base materials, quasi drugs, wound dressings, anti-adhesion membranes, drug delivery systems, cell culture media Materials, regenerative medicine base materials, fragrances, deodorants, insect repellents, insecticides, base materials for agricultural chemicals, base materials for diagnostic agents, chemical and enzyme reaction solutions, base materials for chemical sensors, base materials for biosensors, It can be used for foods and the like, and particularly preferably applied as a wound dressing material such as a wound dressing sheet.
- the gel sheet of the present invention is prepared by first mixing the lipid peptide type gelling agent and the polymer compound, and optionally a solvent such as water or alcohol, and further adding other additives such as a physiologically active substance and a functional substance.
- -Amorphous gel or sol is obtained by stirring and allowing to stand.
- the obtained gel or sol can be obtained by, for example, dropping an appropriate amount onto a smooth surface, or injecting the gel or sol into an appropriate mold and then allowing it to stand for an appropriate time, or through a freezing / thawing process.
- the gel sheet of the present invention is obtained by solidifying into a (film) shape.
- it is also possible to obtain a gel solidified into a fiber shape or a spherical shape by extruding the obtained amorphous gel using a syringe or the like and quenching.
- the laminate may further include a release film that is stacked on the surface of the sheet opposite to the support.
- the support is not particularly limited as long as it is a support that is usually used in patches, but is preferably selected from, for example, polyurethane, PVA, polypropylene, or a laminated support thereof.
- the laminate obtained in this way can be used suitably for the use of a wound dressing material like a gel sheet.
- the lipid peptide type gelling agent comprising the lipid peptide represented by the formula (1) or a pharmaceutically usable salt thereof used in the present invention is used for water, alcohol, polyhydric alcohol, and hydrophilic organic solvent.
- the peptide part in formula (1) forms a non-covalent intermolecular bond by hydrogen bonding, while the lipid part in formula (1) self-assembles so as to be hydrophobically packed, as shown in FIG.
- Such a cylindrical secondary aggregate that is, a fiber or a lamellar secondary aggregate as shown in FIG. 9 is formed.
- FIG. 9 For reference, FIG.
- FIG. 7 shows an example of a conceptual diagram of self-assembly and gelation of lipid peptides used as gelling agents in water, alcohol, polyhydric alcohol, and hydrophilic organic solvent (however, in the present invention, all lipids Peptides do not necessarily take the form of self-assembly and gelation shown in FIG.
- the lipid peptide (a) assembles around the lipid part which is a hydrophobic site (b), and forms a fiber (c) by self-assembly.
- the fiber When the fiber is formed in the above-described hydrophilic liquid such as water, the fiber forms a three-dimensional network structure (see, for example, (d) in FIG. 7). By forming a bond between the hydrophilic liquids and swelling, the entire hydrophilic liquid is gelled.
- FIG. 8 shows an example of a conceptual diagram of lipid peptide self-assembly and gelation in a hydrophobic organic solvent (however, in the present invention, all lipid peptides are self-assembly and gelation shown in FIG. 8).
- the lipid peptide molecule (a) assembles around the histidine part, which is a hydrophilic site (e), and forms a fiber (f) by self-assembly.
- the fiber When the fiber is formed in a hydrophobic organic solvent, the fiber forms a three-dimensional network structure (see, for example, (g) in FIG. 2), and further, between the lipid portion on the fiber surface and the hydrophobic organic solvent.
- the whole hydrophobic organic solvent is gelled by forming a bond with and swelling.
- the lipid peptide used as a gelling agent in the present invention is a zwitterionic compound having a carboxyl group at the C-terminal and an amino group derived from the side chain of the peptide moiety-(CH 2 ) n-X group.
- the ionic state is in an equilibrium between four states, a state in which only the carboxyl group is anionized, a state in which only the amino group is cationized, a state in which zwitterion is formed, and a state in which both substituents are not ionized. Conceivable.
- lipid peptide molecules are positively charged in the acidic region by positively charging the terminal amino group derived from the — (CH 2 ) nX group of the peptide portion in the acidic region. It is considered that the terminal carboxyl group at the C-terminal of the peptide part is negatively charged and anionized, and there are many zwitterionized states in the neutral region.
- the affinity of the peptide part with water is enhanced, and the long chain part, which is a hydrophobic part, is self-assembled so as to keep the contact with water away, thereby forming nanofibers.
- the long chain part which is a hydrophobic part
- ionic bonds of cations and anions are formed between the nanofibers to form a network structure in which a crosslinked structure is formed.
- the formation of this network structure is considered to express excellent hydrogel forming ability by allowing more water to be taken in.
- a polyvinyl alcohol solution forms a cross-linked hydrogen bond of an OH group by repeating a state below the freezing point by freezing and a state above the freezing point by melting, so that the low molecular weight compound of the present invention and polyvinyl alcohol It is thought that fiber formation and gel formation were strongly promoted by hydrogen bond interaction. With this huge bond effect, highly efficient water uptake becomes possible, and the gel sheet of the present invention having a new feeling of use can be obtained. It is presumed that formation was possible. Therefore, we believe that the mechanism presented here has created a huge interaction between the fiber structure of low molecular weight compounds and the network of high molecular weight compounds, which surprisingly led to the formation of regular gels (gel sheets). .
- the solid obtained here was dissolved in a mixed solution of 600 g of water and 750 g of methanol, and 30.5 mL (183.2 mmol) of 6N hydrochloric acid was added thereto for neutralization to precipitate a solid, followed by filtration.
- the obtained solid was dissolved in a mixed solution of 120 g of tetrahydrofuran and 30 g of water at 60 ° C., 150 g of ethyl acetate was added, and the mixture was cooled from 60 ° C. to 30 ° C.
- Example 1 Preparation of gel sheet
- N-palmitoyl-Gly-His synthesized above was dissolved in 50 mM phosphate buffer (pH 7.5) at a concentration of 1% (w / w) at 100 ° C. in a sealed system.
- the gum arabic (Wako Pure Chemical Industries Ltd.) was dripped there so that it might become the density
- FIG. 1 a photograph of a state after being dropped on a glass petri dish and allowed to stand overnight is shown in FIG. 1 (photograph added to the results in Table 1), after standing overnight in N-palmitoyl-Gly-His + arabic gum.
- FIG. 2 shows an enlarged photograph of the state
- FIG. 3 shows an enlarged photograph of the state after standing overnight in N-palmitoyl-Gly-His + PVA.
- FIG. 4 gum arabic
- FIG. 5 PVA
- a gel sheet As shown in Table 1 and FIG. 1 to FIG. 3, in a blend system of N-palmitoyl-Gly-His and gum arabic or a blend system of N-palmitoyl-Gly-His and PVA, the sheet is left to stand overnight. The formation of a gel (hereinafter referred to as a gel sheet) was confirmed. The gel sheet formed of N-palmitoyl-Gly-His and gum arabic was stretchable, and the dried film (sheet) was thin, rich and hydrophilic.
- the gel sheet formed of N-palmitoyl-Gly-His and PVA has strong elasticity
- the membrane (sheet) is dry and has low hydrophilicity (affinity with water by milliQ water dripping), and is relatively thick. The part was shrinking.
- each gel sheet was enriched again after dropping milliQ, and did not become an (amorphous) gel, and the result was that the water absorbability of the film (sheet) was low.
- formation of a fiber structure derived from N-palmitoyl-Gly-His was confirmed in a gel sheet formed of N-palmitoyl-Gly-His and gum arabic or PVA.
- Example 2 and Example 3 formed a gel, but Comparative Examples 1 to 3 containing no N-palmitoyl-Gly-His were in a solution state. Subsequently, these gels and solutions were poured into a 20 mm ⁇ 20 mm square hole in a 3 mm-thick silicone sheet (manufactured by Tigers Polymer Co., Ltd.) mounted on a glass substrate using a spatula or a dropper. The sheet substrate was cooled at ⁇ 24 ° C. for 30 minutes and then allowed to stand at room temperature (about 25 ° C.) for 30 minutes, and sheet formation was observed. This freezing (cooling at ⁇ 24 ° C. for 30 minutes) -thawing (standing at room temperature for 30 minutes) operation was performed until a sheet was obtained, and the number of repetitions was counted as the number of freeze-thaw repetitions. The obtained results are shown in Table 2.
- Example 2 and Example 3 containing N-palmitoyl-Gly-His As shown in Table 2, in Example 2 and Example 3 containing N-palmitoyl-Gly-His, the number of repetitions of freeze-thaw until solidifying into a sheet and forming a gel sheet was 2 or 1 In Comparative Example 1 containing N-palmitoyl-Gly-His and containing only PVA at the same concentration as in Examples 2 and 3, the sheeting was easily achieved. It became. The number of repeated freeze-thaw cycles can be reduced by increasing the PVA concentration (Comparative Example 2 and Comparative Example 3). As a result, it was found that Example 2 and Example 3 were superior in that the number of repetitions of melting could be reduced.
- Example 6 As shown in Table 3, as the amount of N-palmitoyl-Gly-His was increased, the amount of PVA required for forming the gel sheet could be reduced. Particularly in Example 6, by adding 0.2 g of N-palmitoyl-Gly-His, the PVA content can be reduced to 0.5 g. I was able to improve. On the other hand, in Comparative Example 3 (repost) which does not contain N-palmitoyl-Gly-His, 2 g of PVA is required for solidifying into a sheet, and as a result, the pure water content is only 80% (w / w). It was.
- Example 7 and 8 Comparative Example 4: Sensory test of gel sheet
- N-palmitoyl-Gly-His, PVA (manufactured by Kuraray Co., Ltd.) and pure water (manufactured by Kyoei Pharmaceutical Co., Ltd., Japanese Pharmacopoeia sterilized water) synthesized above are screw tubes (( In addition to MaruM Co., Ltd., No. 5), in a dry bath incubator (First Gene), heat (90 ° C to 105 ° C, 60 minutes), dissolve, and stir until cooled to room temperature It was. After stopping stirring and allowing to stand, Example 7 and Example 8 formed a gel, but Comparative Example 4 was in a solution state.
- the obtained gel sheet was placed on and adhered to a polypropylene nonwoven fabric, and then the gel sheet on the nonwoven fabric was attached to the back of the hand, and then the nonwoven fabric was removed. Then, a sensory test was performed on the feeling of use in a blind test. In addition, after the sensory test, the hands were washed carefully with soap immediately. The sensory test was evaluated on five items according to the following evaluation criteria. ⁇ 1. Evaluation criteria for ease of application> When the gel sheet on the nonwoven fabric was pasted on the skin, the one that could be pasted quickly was marked with ⁇ , and the one that was difficult to stick was marked with ⁇ . ⁇ 2.
- Example 7 As shown in Table 4, in Example 8, in which 0.2 g of N-palmitoyl-Gly-His and 0.5 g of PVA were blended, the ease of sticking, the touch, the cool feeling, and the stickiness were all good. In Example 7 where the blending amount of N-palmitoyl-Gly-His was 0.1 g, both the ease of sticking and the cool feeling were good, but there were some problems with the touch and stickiness. (Example 7). In each of the examples, there was a slight problem with ease of peeling.
- Comparative Example 4 in which only Palmoyl-Gly-His was not blended and 0.5 g of PVA was blended was good in terms of cooling feeling, but first, the adhesion to the nonwoven fabric itself was difficult, and it was difficult for the skin. It was difficult to adhere (stick), and when it was attached to the skin, the sheet was broken. In addition, the skin feels bad, the peeling occurs, and most of the gel sheet remains on the skin. In addition, after the above sensory test, there were no skin problems such as skin irritation and itching.
- Example 9 to Example 13 Comparative Example 5 to Comparative Example 8: Drug mixing test of gel sheet
- Palmitoyl-Gly-His, PVA (manufactured by Kuraray Co., Ltd.), pure water (manufactured by Kyoei Pharmaceutical Co., Ltd., Japanese Pharmacopoeia Sterile Water) and drugs in the amounts shown in Table 5 are screw tubes (manufactured by Maruemu Co., Ltd.) In addition to No. 2), the mixture was heated (90 ° C. to 105 ° C., 60 minutes) with a dry bath incubator (manufactured by First Gene), dissolved, and stirred until cooled to room temperature. Stirring was stopped, and after standing, a gel or solution was obtained.
- Example 9 and Comparative Example 5 (-)-Menthol Formulation (-)-Menthol (manufactured by Tokyo Chemical Industry Co., Ltd.) was selected as the drug to be blended (see Table 5). Heated and dissolved in a dry bath incubator, stirred until cooled to room temperature, allowed to stand at room temperature, and then Example 9 formed a gel, but Comparative Example 5 without N-palmitoyl-Gly-His was It became a solution state.
- Example 10 and Comparative Example 6 DL-Camphor Formulation DL-Camphor (manufactured by Junsei Chemical Co., Ltd.) was selected as the drug to be blended (see Table 5). Heated and dissolved in a dry bath incubator and stirred until cooled to room temperature. After standing at room temperature, Example 10 formed a gel, but Comparative Example 6 containing no N-palmitoyl-Gly-His was It became a solution state.
- Example 11 and Comparative Example 7 (-) Menthol and DL-Camphor Formulation (-)-Menthol (manufactured by Tokyo Chemical Industry Co., Ltd.) and DL-Camphor (manufactured by Junsei Chemical Co., Ltd.) was selected (see Table 5). Heated and dissolved in a dry bath incubator and stirred until cooled to room temperature. After standing at room temperature, Example 11 formed a gel, but Comparative Example 7 containing no N-palmitoyl-Gly-His was It became a solution state.
- Example 12 and Example 13 and Comparative Example 8 Urea Compounding Prescription Urea (manufactured by Junsei Chemical Co., Ltd.) was selected as the drug to be blended (see Table 5). Heated and dissolved in a dry bath incubator, stirred until cooled to room temperature, and allowed to stand at room temperature, then Example 12 and Example 13 formed a gel but did not contain N-palmitoyl-Gly-His Comparative Example 8 was in a solution state.
- This gel was transferred to a syringe (manufactured by Terumo Corp.) and extruded into methanol (manufactured by Kanto Chemical Co., Ltd.) cooled to ⁇ 20 ° C. to solidify the gel into a fiber shape to obtain gel fibers. Subsequently, after removing methanol, it was dried to obtain a dehydrated gel fiber (gel fiber during dehydration).
- the obtained gel fiber was immersed in a styrene non-charged rectangular case (36 mm ⁇ 36 mm ⁇ 14 mm) containing 3 mL of pure water to make the gel fiber absorbed (gel fiber at the time of water absorption), and at the time of dehydration / water absorption Changes in the shape of the gel fibers over time were observed.
- the observation photograph of the gel fiber at the time of dehydration / at the time of water absorption is shown in FIG.
- N-palmitoyl-Gly-His was blended with PVA as a gelling agent to form a gel, which improved the gel shape-forming ability and significantly increased the strength of the spun fiber. It was.
- the gel fiber thus obtained can be expected to be applied to various uses, particularly wound dressings, like the gel sheet of the present invention.
- the laminate (so-called patch) prepared using the gel sheet of the present invention. Can be used in combination.
- Example 16 Sheeting of palmitoyl-Gly-His hydrogel using 50% ethanol water immersion solution
- Example 17 Sheeting of palmitoyl-Gly-His hydrogel using 70% ethanol water immersion solution
- 0.1 g of N-palmitoyl-Gly-His synthesized above, 1 g of gelatin (manufactured by Wako Pure Chemical Industries, Ltd., derived from bovine bone), and 50 mM phosphate buffer (manufactured by Wako Pure Chemical Industries, Ltd., pH 7. 4) 8.9 g was added to a screw tube (manufactured by Maruemu Co., Ltd., No.
- each sheet is mounted on a measurement table, and using a spherical plunger, load cell: 200 N, amplifier magnification: 10 times, storage pitch: 0.03 seconds, measurement distortion rate: 99.95%, measurement speed: 1 mm / Second, sample thickness: 20 mm, contact surface diameter: 1.5 mm, ethanol immersion sheet (Example 14), water immersion sheet after ethanol immersion (Example 15), methanol immersion sheet (implementation) at room temperature Example 18) The rupture stress and rupture deformation distance of the water-substituted sheet after immersion in methanol (Example 19) were measured. The obtained results are shown in FIGS.
- the methanol-immersed sheet was large in breaking stress, and the rupture deformation distance was long in the water-substituted sheet after methanol immersion. That is, it was shown that the sheet is hard and does not stretch after being immersed in methanol (after coagulation), but by supplying water by water replacement, it becomes a soft and progressive sheet with water retention.
- Example 18 ⁇ Scanning electron microscope (SEM) observation of methanol-immersed sheet of N-palmitoyl-Gly-His>
- SEM scanning electron microscope
- FIG. 12 (a) N-palmitoyl-Gly-His fibers were also confirmed in the coagulated gel (FIG. 12 (a)), and many pores like pores were observed on the sheet surface (FIG. 12 ( b)). That is, it was considered that the pores were caused by the water absorption mechanism of the N-palmitoyl-Gly-His gel sheet, and the deformability and strength of the gel sheet were adjusted.
- phosphate buffer solution phosphate buffer manufactured by Wako Pure Chemical Industries, Ltd.
- a heat-resistant screw mouth glass bottle manufactured by Iwaki (AGC Techno Glass Co., Ltd., for 100 mL)
- pH 7.4
- composition Na 2 HPO 4 7.6 g, K
- Example 21 Sheeting of palmitoyl-Gly-His hydrogel using sodium lactate immersion liquid (1)] (A-3) 8.8% PVA-phosphate buffer solution 6.3 g prepared previously, (b-1) 20% palmitoyl-Gly-His free pentylene glycol dispersion 0.4 g, (c) 1.5 g of a 2% sodium alginate aqueous solution, 0.4 g of glycerin (manufactured by ITO Co., Ltd.) and 0.4 g of 1,3-butylene glycol (manufactured by ITO Co., Ltd.) In addition to No. 7), a dry bath incubator (manufactured by First Gene) was heated and dissolved at 80 ° C.
- a sheet is mounted on a measurement table, and using a spherical plunger, load cell: 200 N, amplifier magnification: 10 times, storage pitch: 0.03 seconds, measurement distortion: 99.95%, measurement speed: 1 mm / Second, sample thickness: 20 mm, contact surface diameter: 1.5 mm, measured the breaking stress and breaking deformation distance of the washed sheet after immersion in aqueous sodium lactate solution.
- the breaking stress was 2.48 ⁇ 10 5 Pa
- the breaking deformation distance was 4.98 mm.
- Example 22 Sheeting of palmitoyl-Gly-His hydrogel using sodium lactate immersion liquid (2)] (A-1) 5.5 g of 5% PVA-phosphate buffer prepared earlier, (b-2) 2 g of hexanediol dispersion of 5.13% palmitoyl-Gly-His free form, (c) 2% alginic acid Add 1.5 g of sodium salt aqueous solution and 0.5 g of propylene glycol (manufactured by Junsei Kagaku Co., Ltd.) to a glass vial tube with a lid (manufactured by Maruemu Co., Ltd., No.
- a sheet is mounted on a measurement table, and using a spherical plunger, load cell: 200 N, amplifier magnification: 10 times, storage pitch: 0.03 seconds, measurement distortion: 99.95%, measurement speed: 1 mm / Second, sample thickness: 20 mm, contact surface diameter: 1.5 mm, measured the breaking stress and breaking deformation distance of the washed sheet after immersion in aqueous sodium lactate solution.
- the breaking stress was 1.38 ⁇ 10 5 Pa and the breaking deformation distance was 2.51 mm.
- Example 23 Sheeting of palmitoyl-Gly-His hydrogel using sodium lactate immersion liquid (3)
- the previously prepared (h) 1% -palmitoyl-Gly-His, 2% PVA dispersion 5 g is added to a glass vial tube with a lid (manufactured by Maruemu Co., Ltd., No. 7), and a dry bath incubator (Manufactured by First Gene) and dissolved by heating at 80 ° C. for 5 minutes. About 4 g of this solution was dispensed into a stainless steel petri dish (inner diameter 5.5 cm) and allowed to stand at room temperature for 5 minutes to gel.
- Example 24 Sheeting of palmitoyl-Gly-His hydrogel using sodium lactate immersion liquid (4)
- the previously prepared (h) 1% -palmitoyl-Gly-His, 4.28 g of 2% PVA dispersion, 0.02 g of polyvinyl pyrrolidone (BASF Japan KK) and propylene glycol (manufactured by Junsei Kagaku KK) 0 .7 g was added to a glass vial tube with a lid (manufactured by Maruemu Co., Ltd., No. 7), and dissolved in a dry bath incubator (manufactured by First Gene) at 80 ° C. for 5 minutes.
- a dry bath incubator manufactured by First Gene
- Example 25 Sheeting of palmitoyl-Gly-His hydrogel using sodium lactate immersion liquid (5)
- About 4 g of (h) 1% -palmitoyl-Gly-His, 2% PVA dispersion prepared earlier was dispensed into a stainless steel petri dish (inner diameter 5.5 cm) and allowed to stand at room temperature for 5 minutes for gelation. .
- 5 g of a 50% aqueous sodium lactate solution manufactured by Junsei Chemical Co., Ltd. was added to the petri dish, the gel was immersed for 10 minutes, and then washed 3 times with 10 g of pure water to obtain a white sheet.
- Example 26 Sheeting of palmitoyl-Gly-His hydrogel using cellulose support
- the previously prepared (h) 1% -palmitoyl-Gly-His, 2% PVA dispersion 5 g is added to a glass vial tube with a lid (manufactured by Maruemu Co., Ltd., No. 7), and a dry bath incubator (Manufactured by First Gene) and dissolved by heating at 80 ° C. for 5 minutes.
- This solution was dropped onto a cellulose fiber (manufactured by Advantech Toyo Co., Ltd., qualitative filter paper No.
- Example 27 Sodium polyacrylate-containing sheet using sodium lactate immersion liquid] (A-2) 6.4% PVA-phosphate buffer solution 5.3 g prepared earlier, (b-1) 20% palmitoyl-Gly-His free pentylene glycol dispersion 0.4 g, (c) 1.5 g of 2% sodium alginate aqueous solution, 0.4 g of glycerin (manufactured by ITO Co., Ltd.), 0.4 g of 1,3-butylene glycol (manufactured by ITO Co., Ltd.), and (d) 2.5% poly Add 1.5 g of sodium acrylate to a glass vial tube with a lid (manufactured by Marumu Co., Ltd., No.
- a sheet is mounted on a measurement table, and using a spherical plunger, load cell: 200 N, amplifier magnification: 10 times, storage pitch: 0.03 seconds, measurement distortion: 99.95%, measurement speed: 1 mm / Second, sample thickness: 20 mm, contact surface diameter: 1.5 mm, and measured the breaking stress and breaking deformation distance of the washed sheet sheet after immersion in an aqueous sodium lactate solution at room temperature.
- the breaking stress was 1.96 ⁇ 10 5 Pa
- the breaking deformation distance was 3.81 mm.
- Example 28 Sodium polyacrylate and laponite XLG-containing sheet using sodium lactate immersion liquid] (A-2) 6.4% PVA-phosphate buffer solution (5.8 g) prepared earlier (b-1) 20% palmitoyl-Gly-His free pentylene glycol dispersion 0.4 g, (c) 2 g of 2% sodium alginate aqueous solution, and 0.4 g of glycerin (manufactured by ITO), 0.4 g of 1,3-butylene glycol (manufactured by ITO), and (d) 2.5% sodium polyacrylate 1 g, (e) 0.5% Laponite XLG 0.5 g was added to a glass vial tube with a lid (manufactured by Marmu Co., Ltd., No.
- Comparative Example 9 and Comparative Example 10 were viscous sols, and Example 29 and Example 30 were gelled. Titanium diisopropoxybis (triethanolaminate) (manufactured by Matsumoto Fine Chemical Co., Ltd.) was added thereto as a crosslinking agent while stirring by vortex. The sheet was poured into a polystyrene square case (type 2) (manufactured by AS ONE Co., Ltd.) and allowed to stand at room temperature for 1 day, and the formation of the sheet was objectively observed.
- Example 29 and Example 30 blended with N-palmitoyl-Gly-His were excellent in ease of sticking, touch, cool feeling, stickiness, and ease of peeling.
- Comparative Example 9 and Comparative Example 10 which did not contain palmitoyl-Gly-His were good in terms of ease of sticking, touch and cool feeling, but the gel itself was sticky and used. The problem was recognized. Moreover, when it made it adhere to skin, the twist of gel was seen and the subject at the time of peeling also remained. In addition, after carrying out the above sensory test, there were no skin troubles such as skin irritation and itching in any of the Examples and Comparative Examples.
- Nembutal (Dainippon Sumitomo Pharma Co., Ltd., 1.3 ⁇ L / g intramuscular administration)
- the epidermis on the back of the mouse was peeled off with ethanol-sterilized medical scissors to create a circular wound having a diameter of about 10 mm.
- N-palmitoyl-Gly-His gel freeze / thaw sheet, hydrocolloid material (Scratch Powerpad, manufactured by Johnson & Johnson Co., Ltd.), PVA cross-linked hydrogel (Buegel, Nichiban Co., Ltd.) as a covering material on the entire wound surface ))
- PVA gel freezing / thawing gel was coated, and an adhesive cloth adhesive plaster (manufactured by Nichiban Co., Ltd.) was wound thereon to cover each coating material so as not to peel off.
- the N-palmitoyl-Gly-His gel freezing / thawing gel sheet showed a significant healing effect from the second day of treatment according to the wound area analysis. Even in the PVA gel freezing / thawing gel, N-palmitoyl- Next to the Gly-His gel freezing / thawing gel sheet, the healing effect was shown. On the other hand, in the hydrocolloid material and the PVA cross-linked hydrogel, significant effect expression was recognized from the 4th day. Further, as shown in FIG.
- the 50% wound healing average days were the shortest for N-palmitoyl-Gly-His gel freeze / thaw sheet compared to PVA gel freeze / thaw gel, hydrocolloid material, and PVA cross-linked hydrogel. there were. From the above results, it is considered that the N-palmitoyl-Gly-His gel freeze / thaw sheet is useful as a wound covering base material, and that it can be expected to cure wounds at an early stage.
- Example 32 N-palmitoyl-Gly-His frozen, wound skin regeneration effect of thawed gel sheet
- a freezing microtome Leica, CM1510
- skin of normal mice skin of normal mice
- 4 groups of mice used for wound models in Example 31 N-palmitoyl-Gly-His gel freeze / thaw sheet coating, hydrocolloid material coating
- a frozen section (8 ⁇ m) of mouse skin 4 days after the coating treatment with PVA cross-linked hydrogel coating, PVA gel freezing / thawing gel coating was prepared, and for 4 minutes with Mayer's hematoxylin solution (manufactured by Wako Pure Chemical Industries, Ltd.) Washed with water, stained with 1% eosin Y solution (Wako Pure Chemical Industries, Ltd.) for 1 minute, washed with water, dehydrated with 95% ethanol and 99% ethanol, and encapsulated hematoxylin and eosin (HE stain) ), And microscopic
- FIG. 15 normal mouse skin
- FIG. 16 skin model skin treatment day 4 skin
- FIG. 15 in the normal skin HE stained microscopic observation image of a normal mouse, a stratum corneum, a granular layer of the epidermis, and a spiny layer are observed.
- the mouse wound skin pathological image HE stained microscope image
- FIG. 16 the skin coated with the N-palmitoyl-Gly-His frozen gel / thawed gel sheet.
- A the stratum corneum grew, the granulation grew, and an image similar to normal skin was obtained.
- Example 33 Blood cell trapping effect of N-palmitoyl-Gly-His gel
- N-palmitoyl-Gly-His 0.3 g synthesized above and 9.7 g of 50 mM phosphate buffer (manufactured by Wako Pure Chemical Industries, Ltd., pH 7.4) were screwed (No. .5), and heated (90 ° C., 60 minutes) in an aluminum block thermostatic bath (manufactured by Taitec Co., Ltd.) and allowed to cool at room temperature. After 15 hours, gelation was confirmed by the inversion method.
- guinea pig stored blood is a storage solution (5.5 g citric acid, 80 g sodium citrate, 42 sodium chloride, 205 g glucose, which immediately suppresses coagulation after aseptic blood collection. It is prepared by mixing 10 L of purified water) and the amount of blood 1: 1.
- CMC carboxymethyl cellulose
- the state where the fluidity was lost was determined as a gel.
- a hole having a diameter of 7 mm and a depth of 5 mm was formed in the central portion of the gel prepared in the screw tube.
- 150 ⁇ l of guinea pig stored blood was dropped into this hole and allowed to stand overnight at room temperature, which was used for evaluation of the coagulation state of blood described later.
- FIG. 17 in the optical microscope observation, it was confirmed that red blood cells were trapped between the fibers by the fiber structure constituting the N-palmitoyl-Gly-His gel (FIG. 17A), In CMC, a hemolytic action that destroys red blood cells (FIG. 17B) was observed. As shown in FIG. 18, adhesion of blood cell components to the fiber structure constituting the N-palmitoyl-Gly-His gel was observed by SEM observation.
- the fiber structure constituting the N-palmitoyl-Gly-His gel allows blood cell components to be physically trapped between the fibers, thereby controlling the immune environment at the wound site, for example, this suggests that N-palmitoyl-Gly-His gel has an effect of accelerating skin regeneration, such as control of excessive inflammatory reaction by immune reaction and control of inflammatory cell function.
- the gel sheet of the present invention exhibits effectiveness as a wound covering base material by acting on blood cells with a physical regulation mechanism, and can maintain a moist environment without adhesion to the wound surface. It is considered to be useful as a new wound healing promoting base material that can treat wounds quickly with less pain, and as a skin protective material and skin care material used after surgery and prevention of rough skin.
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Abstract
Description
これらの天然多糖類等の天然物系ゲル機材を用いたゲルは、強度が弱いことや柔軟性に乏しいという問題点があり、こうした問題の解決手段として、例えばゲル強化剤としてポリメチル(メタ)アクリレートの官能基を有するメタクリル樹脂粉末、官能基を有するアクリル系の水溶液、ポリエチレングリコール等を添加する方法(特許文献2)、エポキシ化合物系架橋剤等、化学的に架橋し強度を向上させる方法(特許文献3)等が提案されている。しかし、ゲル形成後、ゲル強化剤のモノマーや架橋剤の残存を完全に除去することが難しいため、該ゲルを化粧品や外用剤などに使用する場合に多くの課題がある。
また、層状剥離したクレイを超多官能架橋剤とした有機・無機複合ヒドロゲル(ナノコンポジットゲル)を、乾燥・加熱処理下に加圧処理や減圧処理や延伸処理を行うことにより、高強度・高伸度の特性を保持しながら、フィルム状または繊維状などに成形加工できることが報告されている(特許文献4)が、その製造過程も複雑である課題が指摘されている。
またPVAは、一般に増粘剤や皮膜・フィルム形成剤として使用され、強度の高いゲルを作製することが困難であることから、シート化するには、凍結-融解工程を繰り返す方法などを用いた複雑な製法や、PVAをグルタルアルデヒドで架橋させる製法(非特許文献1)が知られている。しかし手順が複雑である点や、モノマー(グルタルアルデヒド)の混入が全くの皆無ではなく、化粧品や外用剤に用いた際に皮膚や傷口をかえって刺激する危険性があるため、製造方法が容易で且つ安全性の高い素材を用いたゲルが望まれている。
また前述の、生体適合性及び安全性の高い素材として低分子化合物からなるゲル化剤及び該ゲルによるヒドロゲルがいくつか提案されているものの、低分子化合物からなるゲル化剤を用い、自己組織化構造を利用して形成する機能的なシート状ヒドロゲルの報告はなされていない。
さらに本発明者らは、本発明のゲルシートの創傷被覆材への応用を検討するに当たり、アルコール(エタノール)は皮膚に対する刺激性が高く、これを溶媒等に適用することはなるべく避けるべきである点に鑑み、さらに研究を重ねたところ、溶媒等にアルコールを使用せずとも乳酸塩の添加により十分な強度と柔軟性を備えるゲルシートが得られることを見出し、本発明を完成させた。
前記高分子化合物が、該ゲルシートの全質量に対して1%(w/w)を超え50%(w/w)未満の量で含まれてなる、ゲルシートに関する。
第2観点として、前記高分子化合物が、該ゲルシートの全質量に対して2%(w/w)乃至20%(w/w)の量で含まれてなる、第1観点記載のゲルシートに関する。
第3観点として、前記高分子化合物が、ヒドロキシ基を有する直鎖状高分子化合物又は多糖類から選択される、第1観点に記載のゲルシートに関する。
第4観点として、前記高分子化合物が、ポリビニルアルコール、アラビアガム又はゼラチンである、第3観点に記載のゲルシートに関する。
第5観点として、前記低分子脂質ペプチドが下記式(1)で表される脂質ペプチド又はその薬学的に使用可能な塩である、第1観点に記載のゲルシートに関する。
第6観点として、前記R2は、水素原子、メチル基、i-プロピル基、i-ブチル基、又はsec-ブチル基を表す、第5観点に記載のゲルシートに関する。
第7観点として、前記R3は、4-アミノブチル基、4-イミダゾールメチル基、カルバモイルメチル基、2-カルバモイルエチル基、又は3-インドールメチル基を表す、第5観点に記載のゲルシートに関する。
第8観点として、前記R1は、炭素原子数13乃至17の脂肪族基を表し、前記R2は、水素原子、メチル基、又はi-プロピル基を表し、及び前記R3は、4-アミノブチル基、4-イミダゾールメチル基、又は3-メチルインドール基を表す、第5観点に記載のゲルシートに関する。
第9観点として、前記R2は、水素原子を表し、及び前記R3は、4-イミダゾールメチル基を表す、第5観点に記載のゲルシートに関する。
第10観点として、水、アルコール、多価アルコール、親水性有機溶剤、疎水性有機溶剤、又はこれらのうちの2種以上からなる混和溶液を含む、第1観点乃至第9観点のうちいずれか1項に記載のゲルシートに関する。
第11観点として、水、又は水と、アルコール、多価アルコール、油脂、シリコーン油及びエステル系溶剤からなる群から選択される1種以上とからなる混和溶液を含む、第10観点に記載のゲルシートに関する。
第12観点として、水、又は水と、エタノール、2-プロパノール、オレイルアルコール、フェノキシアルコール、グリセリン、プロピレングリコール、ポリエチレングリコール、1,3-ブタンジオール、アクアホホバオイル、ひまし油、オリーブ油、シリコーン油及びアルギン酸プロピレングリコールエステルからなる群から選択される1種以上とからなる混和溶液を含む、第11観点に記載のゲルシートに関する。
第13観点として、多価アルコール、又は、多価アルコールと、アルコール、油脂、シリコーン油、及びエステル系溶剤からなる群から選択される1種以上とからなる混和溶液を含む、第10観点に記載のゲルシートに関する。
第14観点として、グリセリン、プロピレングリコール、ポリエチレングリコール及び1,3-ブタンジオールからなる群から選択される1種以上の多価アルコール、又は、該多価アルコールのうちの少なくとも1種と、エタノール、2-プロパノール、オレオイルアルコール、フェノキシアルコール、アクアホホバオイル、ひまし油、オリーブ油、シリコーン油、及びアルギン酸プロピレングリコールエステルからなる群から選択される1種以上とからなる混和溶液を含む、第13観点に記載のゲルシートに関する。
第15観点として、水と、乳酸カリウム、乳酸ナトリウム及び乳酸カルシウムからなる群から選択される乳酸塩の一種とを含む溶液を含む、第10観点に記載のゲルシートに関する。
第16観点として、さらにグリセリン、プロピレングリコール、ポリエチレングリコール及び1,3-ブチレングリコールからなる群から選択される1種以上の多価アルコールを含む、第15観点に記載のゲルシートに関する。
第17観点として、第1観点乃至第16観点のうちいずれか一項に記載のゲルシートと該シートに重ねられる支持体として不織布、フィルム又はフォームとを有する、積層体に関する。
第18観点として、前記ゲルシートの、支持体と反対側の表面に重ねられる剥離フィルムをさらに備える、第17観点記載の積層体に関する。
第19観点として、前記支持体が、ポリウレタン、PVA、ポリプロピレン、セルロース又はこれらの積層支持体から選択されるものである、第17観点に記載の積層体に関する。
第20観点として、創傷被覆シートである、第1観点乃至第16観点のうちいずれか一項に記載のゲルシートに関する。
第21観点として、皮膚保護シート、皮膚ケアーシートである、第1観点乃至第16観点のうちいずれか一項に記載のゲルシートに関する。
第22観点として、創傷被覆材の用途に使用される、第17観点乃至第19観点のうちいずれか一項に記載の積層体に関する。
第23観点として、皮膚保護シート、皮膚ケアーシートの用途に使用される、第17観点乃至第19観点のうちいずれか一項に記載の積層体に関する。
また本発明のゲルシートは、各成分を混合し、加熱・溶解させて静置することによりシート状の形状を容易に得られ、従来要した煩雑な手順を必要とせずに得られるゲルシートである。
さらに本発明のゲルシートは、前記脂質ペプチド型ゲル化剤に加え、溶媒、そして特に高分子化合物を含みて構成されることにより、従来のゲルとしての性質に加えて、高い強度や高い弾性を有するゲルシートとすることができる。しかも本発明のゲルシートは、前記脂質ペプチド型ゲル化剤により、高分子化合物の含量を低減させることができ、結果、水等の溶媒の含量を増加させることができる。このため、本発明のゲルシートをヒトの皮膚に接触させた際、高分子化合物の配合量増加に由来する肌へのべとつき感、きしみ感を低減でき、且つ、肌触りや保湿感、冷感などの使用感を改善できる。
しかも本発明のゲルシートは、ゲルシート形成後に、アルコール(エタノール等)に浸漬させることにより強固なシートを形成することができ、同時に消毒滅菌も可能である。また、アルコール浸漬に替えて、乳酸塩溶液に浸漬させることによっても、シート化が可能である。
そして本発明のゲルシートは、親水性および疎水性薬剤またはその両方を同時に内包できるという効果を持つ。
したがって、本発明のゲルシートは、医用材料や化粧品用材料等のヒトの皮膚と接触させるような用途に有用であり、特にアルコールの使用が禁忌である創傷被覆材向けの材料としての応用が期待できる。
以下、各成分について説明する。
本発明のゲルシートは、低分子脂質ペプチド又はその薬学的に使用可能な塩からなる少なくとも1種の脂質ペプチド型ゲル化剤を含有することを特徴とする。
前記脂質ペプチドは、分子量1,000以下であることが好ましい。
R1及び隣接するカルボニル基で構成される脂質部としては、例えば、デコイル基、ドデコイル基、ウンデコイル機、ラウロイル基、ドデシルカルボニル基、ミリストイル基、テトラデシルカルボニル基、パルミトイル基、マルガロイル基、オレオイル基、エライドイル基、リノレオイル基、ステアロイル基、バクセノイル基、オクタデシルカルボニル基、アラキドノイル基、イコサノイル基、ベヘノイル基、エルコイル基、ドコシルカルボニル基、リグノセロイル基、ネルボノイル基等を挙げることができ、好ましくは、ミリストイル基、テトラデシルカルボニル基、パルミトイル基、マルガロイル基、オレオイル基、エライドイル基、リノレオイル基、ステアロイル基、及びバクセノイル基等が挙げられる。
上記R3を表す-(CH2)n-X基において、Xは好ましくはアミノ基、グアニジノ基、カルバモイル基、イミダゾール基、ピラゾール基又はインドール基である。
したがって、上記R3を表す-(CH2)n-X基としては、好ましくはアミノメチル基、2-アミノエチル基、3-アミノプロピル基、4-アミノブチル基、カルバモイルメチル基、2-カルバモイルエチル基、3-カルバモイルプロピル基、2-グアニジノエチル基、3-グアニジノプロピル基、ピロールメチル基、4-イミダゾールメチル基、ピラゾールメチル基又は3-インドールメチル基であり、より好ましくは4-アミノブチル基、カルバモイルメチル基、2-カルバモイルエチル基、3-カルバモイルプロピル基、4-イミダゾールメチル基又は3-インドールメチル基であり、より一層好ましくは4-イミダゾールメチル基である。
前記式(1)における、ぺプチド構造の繰り返しの数mは1乃至3の整数である。
この中で好ましいものとしては、ミリストイル-HiS、ミリストイル-Gly-Gly-Gly-Gly-His、パルミトイル-His、パルミトイル-Gly-Gly-Gly-Gly-His、ステアロイル-His、ステアロイル-Gly-Gly-Gly-Gly-Hisが挙げられる。
本発明のゲルシートに含まれる高分子化合物としては例えば、グアーガム、ローカストビーンガム、クィーンスシード、カラギーナン、ガラクタン、アラビアガム、タラガム、タマリンド、ファーセレラン、カラヤガム、トロロアオイ、キャラガム、トラガントガム、ペクチン、ペクチン酸及びナトリウム塩等の塩、アルギン酸及びナトリウム塩等の塩、マンナン;コメ、トウモロコシ、バレイショ、コムギ等のデンプン;キサンタンガム、デキストラン、サクシノグルカン、カードラン、ヒアルロン酸及びその塩、ザンサンガム、プルラン、ジェランガム、キチン、キトサン、寒天、カッソウエキス、コンドロイチン硫酸塩、カゼイン、コラーゲン、ゼラチン、アルブミン;メチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシメチルプロピルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロース及びそのナトリウム等の塩、メチルヒドロキシプロピルセルロース、セルロース硫酸ナトリウム、ジアルキルジメチルアンモニウム硫酸セルロース、結晶セルロース、セルロース末等のセルロース及びその誘導体;可溶性デンプン、カルボキシメチルデンプン、メチルヒドロキシプロピルデンプン、メチルデンプン等のデンプン系高分子、塩化ヒドロキシプロピルトリモニウムデンプン、オクテニルコハク酸トウモロコシデンプンアルミニウム等のデンプン誘導体;アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等アルギン酸誘導体;ポリビニルピロリドン(PVP)、ポリビニルアルコール(PVA)、ビニルピロリドン・ビニルアルコール共重合体、ポリビニルメチルエーテル;ポリエチレングリコール、ポリプロピレングリコール、ポリオキシエチレン・ポリオキシプロピレン共重合体;(メタクリロイルオキシエチルカルボキシベタイン/メタクリル酸アルキル)コポリマー、(アクリレート/アクリル酸ステアリル/メタクリル酸エチルアミンオキシド)コポリマー等の両性メタクリル酸エステル共重合体;(ジメチコン/ビニルジメチコン)クロスポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマーAMP;ポリ酢酸ビニル部分けん化物、マレイン酸共重合体;ビニルピロリドン・メタクリル酸ジアルキルアミノアルキル共重合体;アクリル樹脂アルカノールアミン;ポリエステル、水分散性ポリエステル;ポリアクリルアミド;ポリアクリル酸エチル等のポリアクリル酸エステル共重合体、カルボキシビニルポリマー、ポリアクリル酸及びそのナトリウム塩等の塩、アクリル酸・メタアクリル酸エステル共重合体;アクリル酸・メタアクリル酸アルキル共重合体;ポリクオタニウム-10等のカチオン化セルロース、ポリクオタニウム-7等のジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、ポリクオタニウム-22等のアクリル酸・ジアリルジメチルアンモニウムクロリド共重合体、ポリクオタニウム-39等のアクリル酸・ジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、アクリル酸・カチオン化メタアクリル酸エステル共重合体、アクリル酸・カチオン化メタアクリル酸アミド共重合体、ポリクオタニウム-47等のアクリル酸・アクリル酸メチル・塩化メタクリルアミドプロピルトリメチルアンモニウム共重合体、塩化メタクリル酸コリンエステル重合体;カチオン化オリゴ糖、カチオン化デキストラン、グアーヒドロキシプロピルトリモニウムクロリド等のカチオン化多糖類;ポリエチレンイミン;カチオンポリマー;ポリクオタニウム-51等の2-メタクリロイルオキシエチルホスホリルコリンの重合体及びメタクリル酸ブチル共重合体等との共重合体;アクリル樹脂エマルジョン、ポリアクリル酸エチルエマルジョン、ポリアクリルアルキルエステルエマルジョン、ポリ酢酸ビニル樹脂エマルジョン、天然ゴムラテックス、合成ラテックス等の高分子エマルジョン;ニトロセルロース;ポリウレタン類及び各種共重合体;各種シリコーン類;アクリル-シリコーングラフト共重合体等のシリコーン系各種共重合体;各種フッ素系高分子;12-ヒドロキシステアリン酸及びその塩;パルミチン酸デキストリン、ミリスチン酸デキストリン等のデキストリン脂肪酸エステル;無水ケイ酸、煙霧状シリカ(超微粒子無水ケイ酸)、ケイ酸アルミニウムマグネシウム、ケイ酸ナトリウムマグネシウム、金属石鹸、ジアルキルリン酸金属塩、ベントナイト、ヘクトライト、有機変性粘土鉱物、ショ糖脂肪酸エステル、フラクトオリゴ糖脂肪酸エステル;ケラチン、ミオシン、アクチン;デコリン及びルミカン等のプロテオグリカン及び糖鎖機能を有するもの;RGDなどの機能性配列を有するペプチド等が挙げられる。
中でも、ヒドロキシ基を有する直鎖状高分子化合物又は多糖類から選択されるものが好ましく、最も好ましくはポリビニルアルコール、アラビアガム又はゼラチンである。
本発明のゲルシートにおいて、前記高分子化合物は、該ゲルシートの全質量に対して1%(w/w)を超え50%(w/w)未満の量で含まれてなる。
好ましくは、該高分子化合物は、該ゲルシートの全質量に対して2%(w/w)乃至20%(w/w)量で、さらに好ましくは同5%(w/w)乃至10%(w/w)の量で含まれてなる。
また本発明のゲルシートにおいて、前記脂質ペプチド型ゲル化剤の濃度は、ゲルシートを形成できる濃度であれば特に限定はされないが、好ましくは該ゲルシートの全質量に対して0.0001乃至50%(w/w)、より好ましくは0.0001乃至20%(w/w)、さらに好ましくは0.1乃至5%(w/w)である。配合量が0.0001%(w/w)より少ないとゲル化剤としての効果が生じない場合があり、50%(w/w)よりも多いと、長期貯蔵時の安定性が得られない場合がある。配合量を0.0001乃至50%(w/w)とすることで、得られたゲルシートに保湿感(しっとり感)及び冷感(ひんやり感)といった官能特性を付与できる。
本発明のゲルシートは、前記脂質ペプチド型ゲル化剤及び前記高分子化合物の他に溶媒、すなわち水、アルコール、多価アルコール、親水性有機溶剤、疎水性有機溶剤、又はそれらの2種以上からなる混和溶液を含む。
前記油脂としては、例えば、ひまし油、オリーブ油等が挙げられる。
前記シリコーン油としては、例えば、ジメチルシリコーン油、メチルフェニルシリコーン油等が挙げられる。
前記エステル系溶剤としては、アルギン酸プロピレングリコールエステル、酢酸エチル、アジピン酸ジヘプチルウンデシル、酢酸ラノリン、イソステアリルグリセリル、イソステアリン酸オクチルドデシル等が挙げられる。
また、創傷被覆材への用途を考慮すると、創傷皮膚へのアルコール(エタノール等)の使用は禁忌であることから、アルコールを使用しない系が望ましい。この場合、本発明のゲルシートに含まれる溶媒としては、前記水に対して、乳酸カリウム、乳酸ナトリウム及び乳酸カルシウムからなる群から選択される乳酸塩の一種を含む溶液とすることにより、十分な強度と柔軟性を有するゲルシートを得ることができる。
また、本発明のゲルシートには、必要に応じて一般的に化粧品、医薬品又は食品に配合される生理活性物質及び機能性物質等の添加成分、例えば油性基剤、保湿剤、感触向上剤、界面活性剤、溶剤、噴射剤、酸化防止剤、安定剤、還元剤、酸化剤、防腐剤、抗菌剤、殺菌剤、キレート剤、pH調整剤、酸、アルカリ、粉体、無機塩、紫外線吸収剤、美白剤、ビタミン類及びその誘導体類、育毛用薬剤、血行促進剤、刺激剤、ホルモン類、抗しわ剤、抗老化剤、ひきしめ剤、冷感剤、温感剤、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤、植物・動物・微生物エキス、鎮痒剤、角質剥離・溶解剤、制汗剤、清涼剤、収れん剤、酵素、核酸、香料、色素、着色剤、染料、顔料、消炎剤、抗炎症剤、抗喘息、抗慢性閉塞性肺疾患、抗アレルギー、免疫調整剤、抗感染症剤及び抗真菌剤等があげられる。
アルキルジメチルタウリン等のアルキルスルホベタイン;アルキルジメチルアミノエタノール硫酸エステル等の硫酸型ベタイン;アルキルジメチルアミノエタノールリン酸エステル等のリン酸型ベタイン;ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、スフィンゴミエリン等のスフィンゴリン脂質、リゾレシチン、水素添加大豆リン脂質、部分水素添加大豆リン脂質、水素添加卵黄リン脂質、部分水素添加卵黄リン脂質、水酸化レシチン等のリン脂質類;シリコーン系両性界面活性剤等;高分子界面活性剤としては、ポリビニルアルコール、アルギン酸ナトリウム、デンプン誘導体、トラガントガム、アクリル酸・メタアクリル酸アルキル共重合体;シリコーン系各種界面活性剤が好ましいものとして挙げられる。
粉体としては、マイカ、タルク、カオリン、セリサイト、モンモリロナイト、カオリナイト、雲母、白雲母、金雲母、合成雲母、紅雲母、黒雲母、パーミキュライト、炭酸マグネシウム、炭酸カルシウム、ケイ酸アルミニウム、ケイ酸バリウム、ケイ酸カルシウム、ケイ酸マグネシウム、ケイ酸ストロンチウム、タングステン酸金属塩、マグネシウム、ゼオライト、硫酸バリウム、焼成硫酸カルシウム、リン酸カルシウム、弗素アパタイト、ヒドロキシアパタイト、セラミックパウダー、ベントナイト、スメクタイト、粘土、泥、金属石鹸(例えば、ミリスチン酸亜鉛、パルミチン酸カルシウム、ステアリン酸アルミニウム)、炭酸カルシウム、ベンガラ、黄酸化鉄、黒酸化鉄、群青、紺青、カーボンブラック、酸化チタン、微粒子及び超微粒子酸化チタン、酸化亜鉛、微粒子及び超微粒子酸化亜鉛、アルミナ、シリカ、煙霧状シリカ(超微粒子無水ケイ酸)、雲母チタン、魚鱗箔、窒化ホウ素、ホトクロミック顔料、合成フッ素金雲母、微粒子複合粉体、金、アルミニウム等の各種の大きさ・形状の無機粉体、及び、これらをハイドロジェンシリコーン、環状ハイドロジェンシリコーン等のシリコーン若しくはその他のシラン若しくはチタンカップリング剤等の各種表面処理剤で処理を行って疎水化若しくは親水化した粉体等の無機粉体;デンプン、セルロース、ナイロンパウダー、ポリエチレン末、ポリメタクリル酸メチル末、ポリスチレン末、スチレンとアクリル酸の共重合体樹脂粉末、ポリエステル末、ベンゾグアナミン樹脂粉末、ポリエチレンテレフタレート・ポリメチルメタクリレート積層末、ポリエチレンテレフタレート・アルミニウム・エポキシ積層末等、ウレタン粉末、シリコーン粉末、テフロン(登録商標)粉末等の各種の大きさ・形状の有機系粉体及び表面処理粉体、有機無機複合粉体が好ましいものとして挙げられる。
そして得られたゲルまたはゾルは、例えば平滑な面に適当量を滴下したり、或いは、適当な型に注入した後、適当な時間静置させるか、或いは凍結・融解工程を経ることにより、シート(膜)状に固化させ、本発明のゲルシートを得る。
なお、得られた無定形のゲルを、注射器等を用いて押出し、急冷することにより、ファイバー状や球状に固化したゲルを得ることも可能である。
このとき、前記支持体としては、貼付剤において通常使用される支持体であれば特に限定されないが、例えば、ポリウレタン、PVA、ポリプロピレン又はこれらの積層支持体から選択されるものであることが好ましい。
こうして得られた積層体は、ゲルシート同様、創傷被覆材の用途に好適に使用できる。
参考として図7に水やアルコール、多価アルコール、親水性有機溶剤における、ゲル化剤として用いる脂質ペプチドの自己集合化及びゲル化の概念図の一例を示す(但し、本発明において、全ての脂質ペプチドが図7に示す自己集合化及びゲル化の形態をとるとは限らない。)。該脂質ペプチド(a)は疎水性部位である脂質部を中心として集合し(b)、自己集合化によりファイバー(c)を形成する。
上記ファイバーが上述の水等の親水性の液体中で形成されると、このファイバーが三次元網目構造を形成し、(例えば図7における(d)参照)、さらに、ファイバー表面のペプチド部と親水性の液体間で結合を形成して膨潤することにより、親水性の液体全体がゲル化される。
参考として、図8に疎水性有機溶剤中の脂質ペプチドの自己集合化及びゲル化の概念図の一例を示す(但し、本発明において、全ての脂質ペプチドが図8に示す自己集合化及びゲル化の形態をとるとは限らない)。該脂質ペプチド分子(a)は親水性部位であるヒスチジン部を中心として集合し(e)、自己集合化によりファイバー(f)を形成する。そして上記ファイバーが疎水性有機溶剤の中で形成されると、このファイバーが三次元網目構造を形成し(例えば図2における(g)参照)、さらに、ファイバー表面の脂質部と疎水性有機溶剤間で結合を形成して膨潤することにより、疎水性有機溶剤全体がゲル化される。
本発明でゲル化剤として用いる脂質ペプチドは、C末端のカルボキシル基とペプチド部の側鎖-(CH2)n-X基に由来するアミノ基とを有する両イオン性化合物である。そのイオン状態は、カルボキシル基のみが陰イオン化した状態、アミノ基のみが陽イオン化した状態、双性イオン化した状態、及び両置換基ともイオンになっていない状態の4つの状態間で平衡にあると考えられる。
アミノ酸残基の酸解離定数を考慮すると、脂質ペプチド分子は酸性領域ではペプチド部の-(CH2)n-X基に由来する末端アミノ基がプラスに帯電して陽イオン化し、塩基性領域ではペプチド部C末端の末端カルボキシル基がマイナスに帯電して陰イオン化し、中性領域では双性イオン化した状態が多く存在するものと考えられる。
イオン化した状態になるとペプチド部の水との親和性が増強され、疎水部である長鎖部を水との接触を遠ざけるように自己集合化がなされ、ナノファイバーを形成する。その際、双性イオン状態がより多く存在していると、ナノファイバー間で陽イオンと陰イオンによるイオン結合が形成されて架橋構造を形成した網目構造になる。この網目構造の形成により、より多くの水を取り込むことが出来るようになることで、優れたヒドロゲル形成能を発現するものと考えている。
例えば、ポリビニルアルコール溶液は、凍結による凝固点以下の状態と融解による凝固点以上の状態を相互に繰り返すことにより、OH基の架橋水素結合を形成させることから、本発明の低分子化合物とポリビニルアルコールとの水素結合相互作用によりファイバー形成、ゲル形成が強力に促進されたものと考えられ、この巨大結合効果に伴って、高効率的な水の取り込みが可能となり、新しい使用感を持つ本発明のゲルシートの形成が可能となったものと推定される。
従って、本提示のメカニズムにより、低分子化合物のファイバー構造と高分子化合物のネットワークとの間に巨大な相互作用が生まれ、これが驚くべきことに定形のゲル(ゲルシート)形成につながったものとみている。
なお、以下の実施例で用いる略記号の意味は、次のとおりである。
Gly:グリシン
His:ヒスチジン
PVA:ポリビニルアルコール
本実施例で用いた脂質ペプチドは、以下に示す方法で合成した
500mLの4つ口フラスコに、ヒスチジン14.2g(91.6mmol)、N-パルミトイル-Gly-メチル30.0g(91.6mmol)、トルエン300gを投入し、塩基であるナトリウムメトキサイド 28%メタノール溶液35.3g(183.2mmol)を加え、油浴で60℃に加熱し1時間撹拌を続けた。その後、油浴を外し、25℃まで放冷し、この溶液をアセトン600gで再沈殿させ、濾取した。ここで得られた固体を、水600gとメタノール750gの混合溶液に溶解し、ここに6規定塩酸30.5mL(183.2mmol)を加えて中和し固体を析出させ、ろ過した。次に、得られた固体をテトラヒドロフラン120gと水30gの混合液に60℃で溶解させ、酢酸エチル150gを加え、60℃から30℃まで冷却した。その後、析出した固体をろ過した。さらに得られた固体を、テトラヒドロフラン120gとアセトニトリル60g溶剤中に溶解し、60℃に加熱し、1時間撹拌した後に冷却し、ろ過した。ここで得られた固体を水120gで洗浄し、ろ過後に減圧乾燥を行いN-パルミトイル-Gly-Hisフリー体(以下、単にN-パルミトイル-Gly-Hisとも称する)の白色の結晶、26.9g(収率65%)を得た。
上記で合成したN-パルミトイル-Gly-Hisを、1%(w/w)の濃度で50mMリン酸緩衝液(pH7.5)に、密封系にて100℃で溶解させた。そこへアラビアガム(和光純薬工業(株))を10%(w/w)の濃度になるように滴下し、ゲルを形成させた。200μlを採取してガラスシャーレに滴下し、一晩、静置した後のゲルの状態を観察した。また、一晩経過後のゲルに、milliQ水を滴下し、水との親和性を確認した。またアラビアガムの代わりにPVA(和光純薬工業(株)製、n=1500~1800)を10%(w/w)の濃度にて滴下してゲル形成し、同様の手順にて一晩静置後の状態を観察した。
なお、比較として、N-パルミトイル-Gly-Hisを用いず、アラビアガムのみ、又はPVAのみを用い、同様の操作にてガラスシャーレに滴下し、一晩静置後の状態を同様に観察した。
観察結果から、水との親和性が確認できたものを○、水との親和性が確認できないものを×として評価した。結果を表1に示す。
また、ガラスシャーレに滴下し、一晩静置後の状態の写真を図1(表1の結果に写真を付加したもの)に、N-パルミトイル-Gly-His+アラビアガムの一晩静置後の状態の拡大写真を図2に、N-パルミトイル-Gly-His+PVAの一晩静置後の状態の拡大写真を図3に示す。
さらに、一晩静置後の各ゲルの光学顕微鏡による観察写真を図4(アラビアガム)及び図5(PVA)に示す。
N-パルミトイル-Gly-Hisとアラビアガムにより形成されたゲルシートは伸縮性があり、乾燥した膜(シート)の厚さは薄く、豊潤し、親水性であった。
一方、N-パルミトイル-Gly-HisとPVAにより形成されたゲルシートは強い弾力性をもち、膜(シート)は乾燥し親水性(milliQ水滴下による水との親和性)が低く、比較的厚く端部が収縮していた。
また、いずれのゲルシートも、milliQ滴下後に再び豊潤して(無定形の)ゲルとはならず、膜(シート)の水吸収性は低いとする結果が得られた。
さらに図4及び図5に示すように、N-パルミトイル-Gly-Hisとアラビアガム又はPVAにより形成されたゲルシートにおいて、N-パルミトイル-Gly-Hisに由来するファイバー構造の形成が確認された。
上記で合成したN-パルミトイル-Gly-His、PVA((株)クラレ製)及び純水(共栄製薬(株)製 日本薬局方滅菌水)を下記表2に示す配合量にてスクリュー管((株)マルエム製、No.5)にそれぞれ加え、ドライ・バス・インキュベーター(First Gene社製)で、加熱(90℃~105℃、60分)し、溶解させ、室温に冷却するまで撹拌を行った。撹拌を止め、静置後、実施例2及び実施例3はゲルを形成したが、N-パルミトイル-Gly-Hisを含まない比較例1乃至比較例3は溶液状態となった。
次いで、これらのゲル及び溶液を、ガラス基板に装着した厚さ3mmのシリコーンシート(タイガースポリマー(株)製)内の20mm×20mmの正方形孔内に、スパーテル又はスポイトを用いて流し込んだ。このシート基材を-24℃で30分間冷却後、室温(約25℃)で30分間静置し、シート形成を観察した。この凍結(-24℃で30分間冷却)-融解(室温で30分間静置)操作を、シートが得られるまで行い、その繰り返し回数を凍結-融解繰り返し回数としてカウントした。得られた結果を表2に示す。
なお、PVAの濃度を上げることにより凍結-融解繰り返し回数を少なくすることはできる(比較例2及び比較例3)が、N-パルミトイル-Gly-Hisの添加によりPVA濃度を低減しても凍結-融解繰り返し回数を少なくできるという点で、実施例2及び実施例3が優位であるとする結果となった。
上記で合成したN-パルミトイル-Gly-His、PVA((株)クラレ製)及び純水(共栄製薬(株)製 日本薬局方滅菌水)を下記表3に示す配合量にてスクリュー管((株)マルエム製、No.5)にそれぞれ加えた。このとき、後の凍結-融解工程を1回実施するだけでシート状に固化するように、配合量を調整した。ドライ・バス・インキュベーター(First Gene社製)で、加熱(90℃~105℃、60分)し、溶解させ、室温に冷却するまで撹拌を行った。撹拌を止め、静置後、実施例4乃至実施例6はゲルを形成した。
次いで、これらのゲルを、ガラス基板に装着した厚さ3mmのシリコーンシート(タイガースポリマー(株)製)内の20mm×20mmの正方形孔内に、スポイトを用いて流し込んだ。このシート基材を-24℃で30分間冷却後、室温(約25℃)で30分間静置し、シート形成を確認した。得られた結果を表3に示す。
一方、N-パルミトイル-Gly-Hisを含まない比較例3(再掲)においては、シート状に固化させるのにPVAを2g必要とし、結果、純水含水率は80%(w/w)にとどまった。
このように、表3に示す結果は、N-パルミトイル-Gly-Hisを配合した実施例4乃至実施例6ではより多くの水分を保持でき、またPVAの含有量を減らすことができるため、該ゲルシートを皮膚等に接触させたとき、PVAの配合量増大に伴う肌へのべとつき感やきしみ感といったストレスの軽減及び使用感や冷感(ひんやり感)が良くなるという効果を有することが期待される。
上記で合成したN-パルミトイル-Gly-His、PVA((株)クラレ製)及び純水(共栄製薬(株)製 日本薬局方滅菌水)を下記表4に示す配合量にてスクリュー管((株)マルエム製、No.5)にそれぞれ加え、ドライ・バス・インキュベーター(First Gene社製)で、加熱(90℃~105℃、60分)し、溶解させ、室温に冷却するまで撹拌を行った。撹拌を止め、静置後、実施例7及び実施例8はゲルを形成したが、比較例4は溶液状態となった。
次いで、これらのゲル及び溶液を、ガラス基板に装着した厚さ3mmのシリコーンシート(タイガースポリマー(株)製)内の20mm×20mmの正方形孔内に、スパーテル又はスポイトを用いて流し込んだ。このシート基材を-24℃で30分間冷却後、室温(約25℃)で30分間静置した。この凍結(-24℃で30分間冷却)-融解(室温で30分間静置)操作を計2回繰り返し、シートを得た。
<1.貼付のしやすさ評価基準>
不織布上のゲルシートを肌へ貼付させた際、速やかに貼付可能なものを○、貼付の難しい状態のものを×とした。
<2.肌触りの評価基準>
不織布上のゲルシートを肌へ貼付させた際、肌表面上に滑らかに、ざらつきなく貼付可能なものを○、わずかにざらつきがあったものの、使用上支障のないものを△、滑らかさ又はざらつき感があったものを×とした。
<3.冷感の評価基準>
不織布上のゲルシートを肌へ貼付させた際、貼付と同時に冷感(ヒンヤリ感)のあるもの○、冷感のないものを×とした。
<4.べたつきの評価基準>
不織布上のゲルシートを肌へ貼付させた後、該ゲルシートを肌から除去した際、肌表面にべたつきの残らなかったものを○、わずかにべたつくものの、使用上支障のないものを△、べたつきの残ったものを×とした。
<5.剥がし易さの評価基準>
不織布上のゲルシートを肌へ貼付し、乾燥させた後、よれが生じずに剥がし易かったものを○、わずかに剥がし残しがあったものの、使用上支障のないものを△、ゲルシートの一部が皮膚上に付着してよれが生じ、剥がし難かったものを×とした。
以上、得られた結果を表4に示す。
これに対して、パルミトイル-Gly-Hisを配合せず、PVA0.5gのみ配合した比較例4は、冷感に関しては良好であったが、まず不織布自体への付着性に難があり、肌へ付着(貼付)しにくく、皮膚に付着させるとシートのくずれがみられた。また肌触りが悪く、剥がす際によれが生じ、またゲルシートの大部分ノゲルが肌に残る結果となり、使用感に課題が認められた。
なお、上記官能試験実施後、皮膚刺激、かゆみ等の肌のトラブル等は全く無かった。
下記手順にてN-パルミトイル-Gly-His、PVA及び純水に、薬物として(-)-メントール、DL-カンフル、(-)-メントール及びDL-カンフル、或いは尿素を配合し、ゲルシートの形成について評価した。
<試験手順>
パルミトイル-Gly-His、PVA((株)クラレ製)、純水(共栄製薬(株)製 日本薬局方滅菌水)及び薬物を表5に示す配合量にてスクリュー管((株)マルエム製、No.2)にそれぞれ加え、ドライ・バス・インキュベーター(First Gene社製)で、加熱(90℃~105℃、60分)し、溶解させ、室温に冷却するまで撹拌を行った。撹拌を止め、静置後、ゲル又は溶液を得た。
次いで、これらのゲル及び溶液を、ガラス基板に装着した厚さ3mmのシリコーンシート(タイガースポリマー(株)製)内の20mm×20mmの正方形孔内に、スパーテル又はスポイトを用いて流し込んだ。このシート基材を-24℃で30分間冷却後、室温(約25℃)で30分間静置し、シート形成したものを○、しなかったものを×として評価した。
得られた結果を表5に示す。
配合する薬物として(-)-メントール(東京化成工業(株)製)を選択した(表5参照)。ドライ・バス・インキュベーターで加熱、溶解し、室温に冷却するまで撹拌し、室温静置後、実施例9はゲルを形成したが、N-パルミトイル-Gly-Hisを配合していない比較例5は溶液状態となった。
配合する薬物としてDL-カンフル(純正化学(株)製)を選択した(表5参照)。ドライ・バス・インキュベーターで加熱、溶解し、室温に冷却するまで撹拌し、室温静置後、実施例10はゲルを形成したが、N-パルミトイル-Gly-Hisを配合していない比較例6は溶液状態となった。
配合する薬物として(-)-メントール(東京化成工業(株)製)及びDL-カンフル(純正化学(株)製)を選択した(表5参照)。ドライ・バス・インキュベーターで加熱、溶解し、室温に冷却するまで撹拌し、室温静置後、実施例11はゲルを形成したが、N-パルミトイル-Gly-Hisを配合していない比較例7は溶液状態となった。
配合する薬物として尿素(純正化学(株)製)を選択した(表5参照)。ドライ・バス・インキュベーターで加熱、溶解し、室温に冷却するまで撹拌し、室温静置後、実施例12及び実施例13はゲルを形成したが、N-パルミトイル-Gly-Hisを配合していない比較例8は溶液状態となった。
一方、N-パルミトイル-Gly-Hisを0.1g(1%(w/w))配合した実施例9乃至実施例13においては、ゲルシートの形成がそれぞれ確認され、特に実施例13に示すように、尿素を20%(w/w)という高濃度に含有させた場合においても、シートの形成が確認された。
上記で合成したN-パルミトイル-Gly-His、PVA(和光純薬工業(株)製、n=1500~1800)及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)を表6に示す配合量にてスクリュー管((株)マルエム製、No.5)にそれぞれ加え、ドライ・バス・インキュベーター(First Gene社製)で加熱(100℃、60分)し、室温静置16時間後、試験管倒置法によりゲル化を確認した。この際、流動性がなくなった状態をゲルと判定した。
このゲルをシリンジ(テルモ(株)製)に移し、-20℃まで冷却したメタノール(関東化学(株)製)中に押し出し、ファイバー状にゲルを凝固させ、ゲル繊維を得た。次いで、メタノールの除去後、乾燥させて、脱水させたゲル繊維(脱水時のゲル繊維)を得た。さらに、得られたゲル繊維を3mLの純水の入ったスチロール非帯電角型ケース(36mm×36mm×14mm)に浸漬し、吸水させたゲル繊維(吸水時のゲル繊維)とし、脱水時/吸水時におけるゲル繊維の形状の変化を観察した。脱水時/吸水時におけるゲル繊維の観察写真を図6に示す。
一方、N-パルミトイル-Gly-Hisを含まない比較参考例1は、シリンジからメタノール中に押出し後に脱水させたところ、ファイバー状などの特定の形状を保てず、また吸水させるとPVAの溶解が始まり、形状を保てず、脆弱であった。
すなわち、ゲル化剤としてN-パルミトイル-Gly-HisをPVAとブレンドさせてゲルを形成することにより、ゲルの形状形成能は向上し、さらに、紡糸した繊維の強度が著しく増大したことが示された。
こうして得られたゲル繊維も、本発明のゲルシート同様に種々の用途、特に創傷被覆材の用途への応用が期待でき、例えば本発明のゲルシートを用いて作成された前記積層体(いわゆる貼付剤)と組み合わせて使用することが可能である。
上記で合成したN-パルミトイル-Gly-His0.1g、PVA(和光純薬工業(株)製、平均重合度n=1,500~1,800)1g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)8.9gをスクリュー管((株)マルエム製、No.5)に加え、アルミブロック恒温槽(タイテック(株)製)で加熱(95℃、60分)溶解し、10mLをペトリシャーレ(直径85mm×高さ15mm)に移して静置放冷した。16時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。
次いで、このゲルに99.5%エタノール10mLを滴下し、1時間毎にエタノールを交換する操作を2回行い、この操作を含め計16時間エタノールに浸漬させて白色状のエタノール浸漬シートを得た。
上記で合成したN-パルミトイル-Gly-His0.1g、PVA(和光純薬工業(株)製、平均重合度n=1,500~1,800)1g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)8.9gをスクリュー管((株)マルエム製、No.5)に加え、アルミブロック恒温槽(タイテック(株)製)で加熱(95℃、60分)溶解し、10mLをペトリシャーレ(直径85mm×高さ15mm)に移して静置放冷した。16時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。
次いで、このゲルに99.5%エタノール10mLを滴下し、1時間毎にエタノールを交換する操作を2回行い、この操作を含め計16時間エタノールに浸漬させてシートを得た。さらに、このシートに純水10mLを滴下し、1時間毎に純水を交換する操作を2回行い、この操作を含め計16時間純水に浸漬させて白色状のエタノール浸漬後水置換シートを得た。
上記で合成したN-パルミトイル-Gly-His0.1g、PVA(和光純薬工業(株)製、平均重合度n=1,500~1,800)1g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)8.9gをスクリュー管((株)マルエム製、No.5)に加え、アルミブロック恒温槽(タイテック(株)製)で加熱(95℃、60分)溶解し、10mLをペトリシャーレ(直径85mm×高さ15mm)に移して静置放冷した。16時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。
次いで、このゲルに50%エタノール水10mLを滴下し、1時間後に透明シートを得た。
上記で合成したN-パルミトイル-Gly-His0.1g、ゼラチン(和光純薬工業株式会社製、ウシ骨由来)1g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)8.9gをスクリュー管((株)マルエム製、No.5)に加え、アルミブロック恒温槽(タイテック(株)製)で加熱(95℃、60分)溶解し、10mLをペトリシャーレ(直径85mm×高さ15mm)に移して静置放冷した。16時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。
次いで、このゲルに70%エタノール水10mLを滴下し、5時間後に伸縮性の白色シートを得た。
上記で合成したN-パルミトイル-Gly-His0.1g、PVA(和光純薬工業(株)製、平均重合度n=1,500~1,800)1g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)8.9gをスクリュー管((株)マルエム製、No.5)に加え、ドライ・バス・インキュベーターアルミブロック恒温槽(タイテック(株)製)で加熱(95℃、60分)溶解し、10mLをペトリシャーレ(直径85mm×高さ15mm)に移して静置放冷した。16時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。
次いで、このゲルに99.5%メタノール10mLを滴下し、16時間メタノールに浸漬させて白色状のメタノール浸漬シートを得た。
上記で合成したN-パルミトイル-Gly-His0.1g、PVA(和光純薬工業(株)製、平均重合度n=1,500~1,800)1g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)8.9gをスクリュー管((株)マルエム製、No.5)に加え、ドライ・バス・インキュベーター(First Gene社製)で加熱(95℃、60分)溶解し、10mLをペトリシャーレ(直径85mm×高さ15mm)に移して静置放冷した。16時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。
次いで、このゲルに99.5%メタノール10mLを滴下し、16時間メタノールに浸漬させてメタノール浸漬シートを得た。さらに、このシートに純水10mLを滴下し、1時間毎に純水を交換する操作を2回行い、この操作を含め計16時間純水に浸漬させて白色状のメタノール浸漬後水置換シートを得た。
実施例14、実施例15、実施例18及び実施例19で得た各シートについて、静的粘弾性のパラメーターとして破断応力および破断変形距離をクリープメータ RE-33005B、(株)山電製)により測定した。即ち、各シートを測定台に装着し、球型プランジャーを用いて、ロードセル:200N、アンプ倍率:10倍、格納ピッチ:0.03秒、測定歪率:99.95%、測定速度:1mm/秒、サンプル厚さ:20mm、接触面直径:1.5mm、室温の条件下にて、エタノール浸漬シート(実施例14)、エタノール浸漬後水置換シート(実施例15)、メタノール浸漬シート(実施例18)、メタノール浸漬後水置換シート(実施例19)の破断応力および破断変形距離を測定した。
得られた結果を図10及び図11に示す。
また、図11に示すように、メタノール浸漬シート及びメタノール浸漬後水置換シートの比較においても、破断応力においてはメタノール浸漬シートが大きく、破断変形距離はにおいてはメタノール浸漬後水置換シートが長かった。即ち、メタノール浸漬後(凝固後)は固くて伸びの無いシートであるが、これを水置換により給水させることにより保水性の柔らかな進展性シートとなることが示された。
上記の実施例18で得たメタノール浸漬シートをエネルギー分散型X線分析装置付属走査型電子顕微鏡(SEM)((株)島津製作所製)を用いて低真空観察を行った。得られた結果を図12に示す。
図12に示すように、凝固ゲルにおいても、N-パルミトイル-Gly-Hisのファイバーが確認され(図12(a))、シート表面には気孔の様な孔が多数観察された(図12(b))。
すなわち、この孔がN-パルミトイル-Gly-Hisのゲルシートの吸水機構に起因し、ゲルシートの変形性や強度を調節していることが考えられる結果となった。
上記で合成したN-パルミトイル-Gly-His0.1g、PVA(和光純薬工業(株)製、平均重合度n=1,500~1,800)1g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)8.9gをスクリュー管((株)マルエム製、No.5)に加え、ドライ・バス・インキュベーター(First Gene社製)で加熱(95℃、60分)溶解し、10mLをペトリシャーレ(直径85mm×高さ15mm)に移して静置放冷した。16時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。
次いで、このゲルに50%エタノール水10mLを滴下し、1時間毎に50%エタノール水を交換する操作を2回行い、この操作を含め計16時間、50%エタノール水に浸漬させて、透明な50%エタノール水浸漬シートを得た。
(a-1)5%PVA-リン酸緩衝液の調製
耐熱ネジ口ガラス瓶(iwaki(AGCテクノグラス(株))製、100mL用)にリン酸緩衝液(和光純薬工業(株)製phosphate buffer powder、1/15mol/L、pH=7.4、組成:Na2HPO4 7.6g、KH2PO4 1.8g/純水1L)47.5gおよびPVA(JF17、日本酢ビ・ポバール(株))2.5gを加えて、ドライ・バス・インキュベーター(First Gene社製)で、90℃、60分間加熱を行い、溶解を目視で確認後、室温冷却して、水溶液を得た。
耐熱ネジ口ガラス瓶(iwaki(AGCテクノグラス(株))製、100mL用)にリン酸緩衝液(和光純薬工業(株)製phosphate buffer powder、1/15mol/L、pH=7.4、組成:Na2HPO4 7.6g、KH2PO4 1.8g/純水1L)58.5gおよびPVA(JF17、日本酢ビ・ポバール(株))4gを加えて、ドライ・バス・インキュベーター(First Gene社製)で、90℃、90分間加熱を行い、溶解を目視で確認後、室温冷却して、水溶液を得た。
耐熱ネジ口ガラス瓶(iwaki(AGCテクノグラス(株))製、200mL用)にリン酸緩衝液(和光純薬工業(株)製phosphate buffer powder、1/15mol/L、pH=7.4、組成:Na2HPO4 7.6g、KH2PO4 1.8g/純水1L)145gおよびPVA(JF17、日本酢ビ・ポバール(株))14gを加えて、ドライ・バス・インキュベーター(First Gene社製)で、90℃、90分間加熱を行い、溶解を目視で確認後、室温冷却して、水溶液を得た。
蓋付ガラス製バイアル管((株)マルエム製、No.7)に合成例1で合成したパルミトイル-Gly-Hisフリー体4g及びペンチレングリコール(純正化学(株)製)16gを加えて、ドライ・バス・インキュベーター(First Gene社製)で、加熱(90℃、30分)し、室温冷却して、分散液を得た。
蓋付ガラス製バイアル管((株)マルエム製、No.7)に合成例1で合成したパルミトイル-Gly-Hisフリー体0.5g及び1,2-ヘキサンジオール((株)ITO製)1g、純水8.25gを加えて、ドライ・バス・インキュベーター(First Gene社製)で、加熱(80℃、30分)して、分散液を得た。
蓋付ガラス製バイアル管((株)マルエム製、No.7)にアルギン酸ナトリウム塩(キッコーマンバイオケミファ(株)製)0.5g及び純水を加えて50mLとし、振とうして水溶液を得た。
耐熱ネジ口ガラス瓶(iwaki(AGCテクノグラス(株))製、100mL用)に純水97.5gおよびポリアクリル酸ナトリウム((株)ITO製)2.5gを加えて、ドライ・バス・インキュベーター(First Gene社製)で、80℃、60分間加熱を行い、溶解を目視で確認後、室温冷却して、水溶液を得た。
耐熱ネジ口ガラス瓶(iwaki(AGCテクノグラス(株))製、100mL用)に純水48.75gおよびラポナイトXLG(RockWood Additives社製)1.25gを加えて、ドライ・バス・インキュベーター(First Gene社製)で、80℃、60分間加熱を行い、溶解を目視で確認後、室温冷却して、水溶液を得た。
50%乳酸ナトリウム水溶液(純正化学(株)製)を40gに10gの純水を加えて、40%乳酸ナトリウム水溶液を得た。
150mLガラス瓶(柏洋硝子(株)製)に、PVA(JF17、日本酢ビ・ポバール(株))2g及び純水48gを加えて、ドライ・バス・インキュベーター(First Gene社製)で、100℃、60分間加熱を行い、溶解を目視で確認後、室温冷却して、水溶液を得た。
150mLガラス瓶(柏洋硝子(株)製)に、合成例1で合成したパルミトイル-Gly-His1g、phosphate buffer powder(和光純薬工業(株)製)1g及び純水48gを加え、ドライ・バス・インキュベーター(First Gene社製)で、100℃、60分間加熱し、溶解させた。この溶解液に、先に調製した(g)4%PVA水溶液50gを混合して、95℃、30分間加熱後、超強磁力スターラー((株)日伸理化製、SW-RS077)を用いて、室温下、30分間、300rpmで撹拌して白色状の分散液(静置でゲル化)を得た。
先に調製した(a-3)8.8%PVA-リン酸緩衝液6.3g、(b-1)20%パルミトイル-Gly-Hisフリー体のペンチレングリコール分散液0.4g、(c)2%アルギン酸ナトリウム塩水溶液1.5g、及びグリセリン((株)ITO製)0.4g、1,3-ブチレングリコール(ITO社製)0.4gを、蓋付ガラス製バイアル管((株)マルエム製、No.7)に加えて、ドライ・バス・インキュベーター(First Gene社製)で、80℃、30分間加熱し溶解させた。この溶解液を、ガラスシャーレ(内径6.5cm)に約4g分注し、室温で20分静置しゲル化させた。次いで、(f)40%乳酸ナトリウム水溶液5gをシャーレ内に加えて、ゲルを20分浸漬させた後、純水10gで3回洗浄して、半透明状のシートを得た。
本シートの静的粘弾性のパラメーターとして破断応力および破断変形距離をクリープメータ RE-33005B、(株)山電製)により測定した。即ち、シートを測定台に装着し、球型プランジャーを用いて、ロードセル:200N、アンプ倍率:10倍、格納ピッチ:0.03秒、測定歪率:99.95%、測定速度:1mm/秒、サンプル厚さ:20mm、接触面直径:1.5mm、室温の条件下で、乳酸ナトリウム水溶液浸漬後洗浄シートの破断応力および破断変形距離を測定した。
破断応力は2.48×105Paであり、破断変形距離は、4.98mmであった。
先に調製した(a-1)5%PVA-リン酸緩衝液5.5g、(b-2)5.13%パルミトイル-Gly-Hisフリー体のヘキサンジオール分散液2g、(c)2%アルギン酸ナトリウム塩水溶液1.5g、及びプロピレングリコール(純正化学(株)製)0.5gを、蓋付ガラス製バイアル管((株)マルエム製、No.7)に加えて、ドライ・バス・インキュベーター(First Gene社製)で、80℃、30分間加熱し溶解させた。この溶解液を、ガラスシャーレ(内径6.5cm)に約4g分注し、室温で10分静置しゲル化させた。次いで、(f)40%乳酸ナトリウム水溶液5gをシャーレ内に加えて、ゲルを10分浸漬させた後、純水10gで3回洗浄して、半透明状のシートを得た。
本シートの静的粘弾性のパラメーターとして破断応力および破断変形距離をクリープメータ RE-33005B、(株)山電製)により測定した。即ち、シートを測定台に装着し、球型プランジャーを用いて、ロードセル:200N、アンプ倍率:10倍、格納ピッチ:0.03秒、測定歪率:99.95%、測定速度:1mm/秒、サンプル厚さ:20mm、接触面直径:1.5mm、室温の条件下で、乳酸ナトリウム水溶液浸漬後洗浄シートの破断応力および破断変形距離を測定した。
破断応力は1.38×105Paであり、破断変形距離は、2.51mmであった。
先に調製した(h)1%-パルミトイル-Gly-His、2%PVA分散液5gを、蓋付ガラス製バイアル管((株)マルエム製、No.7)に加えて、ドライ・バス・インキュベーター(First Gene社製)で、80℃、5分間加熱し溶解させた。この溶解液を、ステンレスシャーレ(内径5.5cm)に約4g分注し、室温で5分間静置しゲル化させた。次いで、50%乳酸ナトリウム水溶液(純正化学(株)製)5gをシャーレ内に加えて、ゲルを10分浸漬させた後、純水10gで3回洗浄して、半透明状のシートを得た。
先に調製した(h)1%-パルミトイル-Gly-His、2%PVA分散液4.28g、ポリビニルピロリドン(BASFジャパン(株)製)0.02g及びプロピレングリコール(純正化学(株)製)0.7gを、蓋付ガラス製バイアル管((株)マルエム製、No.7)に加えて、ドライ・バス・インキュベーター(First Gene社製)で、80℃、5分間加熱し溶解させた。この溶解液を、ステンレスシャーレ(内径5.5cm)に約4g分注し、室温で5分間静置しゲル化させた。次いで、50%乳酸ナトリウム水溶液(純正化学(株)製)5gをシャーレ内に加えて、ゲルを10分浸漬させた後、純水10gで3回洗浄して、半透明状のシートを得た。
先に調製した(h)1%-パルミトイル-Gly-His、2%PVA分散液5gを、ステンレスシャーレ(内径5.5cm)に約4g分注し、室温で5分間静置しゲル化させた。次いで、50%乳酸ナトリウム水溶液(純正化学(株)製)5gをシャーレ内に加えて、ゲルを10分浸漬させた後、純水10gで3回洗浄して、白色状のシートを得た。
先に調製した(h)1%-パルミトイル-Gly-His、2%PVA分散液5gを、蓋付ガラス製バイアル管((株)マルエム製、No.7)に加えて、ドライ・バス・インキュベーター(First Gene社製)で、80℃、5分間加熱し溶解させた。この溶解液を、ステンレスシャーレ(内径5.5cm)に装着したセルロース繊維(アドバンテック東洋(株)製、定性濾紙No.101、55mm)上に滴下し、室温で5分間静置しゲル化させた。次いで、50%乳酸ナトリウム水溶液(純正化学(株)製)5gをシャーレ内に加えて、セルロースに担持したゲルを10分浸漬させた後、純水10gで3回洗浄して、セルロースを支持体としたシートを得た。
先に調製した(a-2)6.4%PVA-リン酸緩衝液5.3g、(b-1)20%パルミトイル-Gly-Hisフリー体のペンチレングリコール分散液0.4g、(c)2%アルギン酸ナトリウム塩水溶液1.5g、及びグリセリン((株)ITO製)0.4g、1,3-ブチレングリコール((株)ITO社製)0.4g、そして(d)2.5%ポリアクリル酸ナトリウム1.5gを蓋付ガラス製バイアル管((株)マルエム製、No.7)に加えて、ドライ・バス・インキュベーター(First Gene社製)で、80℃、30分間加熱し溶解させた。この溶解液を、ガラスシャーレ(内径6.5cm)に約4g分注し、室温で20分静置しゲル化させた。次いで、(f)40%乳酸ナトリウム水溶液5gをシャーレ内に加えて、ゲルに20分浸漬後、純水10gで3回洗浄して、半透明状のシートを得た。
本シートの静的粘弾性のパラメーターとして破断応力および破断変形距離をクリープメータ RE-33005B、(株)山電製)により測定した。即ち、シートを測定台に装着し、球型プランジャーを用いて、ロードセル:200N、アンプ倍率:10倍、格納ピッチ:0.03秒、測定歪率:99.95%、測定速度:1mm/秒、サンプル厚さ:20mm、接触面直径:1.5mm、室温の条件下で乳酸ナトリウム水溶液浸漬後洗浄シートシートの破断応力および破断変形距離を測定した。
破断応力は1.96×105Paであり、破断変形距離は、3.81mmであった。
先に調製した(a-2)6.4%PVA-リン酸緩衝液5.8g、(b-1)20%パルミトイル-Gly-Hisフリー体のペンチレングリコール分散液0.4g、(c)2%アルギン酸ナトリウム塩水溶液2g、及びグリセリン((株)ITO製)0.4g、1,3-ブチレングリコール((株)ITO製)0.4g、そして(d)2.5%ポリアクリル酸ナトリウム1g、(e)2%ラポナイトXLG 0.5gを蓋付ガラス製バイアル管((株)マルエム製、No.7)に加えて、ドライ・バス・インキュベーター(First Gene社製)で、95℃、60分間加熱し溶解させた。この溶解液を、ガラスシャーレ(内径6.5cm)に約4g分注し、室温で20分静置しゲル化させた。次いで、50%乳酸ナトリウム水溶液(純正化学(株)製)5gをシャーレ内に加えて、ゲルに240分浸漬後、純水10gで3回洗浄して、白色状のシートを得た。
パルミトイル-Gly-His、PVA(日本酢ビ・ポバール(株)製)、ポリビニルピロリドン(BASFジャパン(株)製)、50mMリン酸緩衝液(pH7.5)を表7に示す配合における配合量にて、スクリュー管((株)マルエム製、No.5)にそれぞれ加え、ドライ・バス・インキュベーター(First Gene製)で、加熱(90℃-105℃、60分)し、室温静置後500rpmにて撹拌した。比較例9及び比較例10は粘性のゾルとなり、実施例29及び実施例30はゲル状となった。ここに、架橋剤としてチタンジイソプロポキシビス(トリエタノールアミネート)(マツモトファインケミカル(株)製)をボルテックスで撹拌しながら加えた。スチロール角型ケース(2型)(アズワン(株)製)に流し込み、室温で1日静置し、シートの形成を達観的に観察した。
<1.貼付のしやすさ 評価基準>
ゲルシートを肌へ貼付させた際、速やかに貼付可能なものを○、貼付の難しい状態のものを×とした。
<2.肌触り 評価基準>
ゲルシートを肌へ貼付させた際、肌表面上に滑らかに、ざらつきなく貼付可能なものを○、わずかにざらつきがあったものの使用上支障のないものを△、滑らかさ又はざらつき感があったものを×とした。
<3.冷感 評価基準>
ゲルシートを肌へ貼付させた際、貼付と同時に冷感(ヒンヤリ感)のあるもの○、冷感のないものを×とした。
<4.べたつき 評価基準>
ゲルシートを肌へ貼付させた後、該ゲルシートを肌から除去した際、肌表面にべたつきの残らなかったものを○、わずかにべたつくものの使用上支障のないものを△、べたつきの残ったものを×とした。
<5.剥がし易さ 評価基準>
ゲルシートを肌へ貼付し、乾燥させた後、よれが生じずに剥がし易かったものを○、わずかに剥がし残しがあったものの使用上支障のないものを△、ゲルシートの一部が皮膚上に付着してよれが生じ、剥がし難かったものを×とした。
以上、得られた結果を表7にあわせて示す。
これに対して、パルミトイル-Gly-Hisを配合していない比較例9および比較例10は、貼付のしやすさ、肌触り、冷感に関しては良好であったが、ゲル自体にべとつきがあり使用感に課題が認められた。また、皮膚に付着させるとゲルのねじれがみられ、剥がす際の課題も残るものとなった。
なお、上記官能試験実施後、皮膚刺激、かゆみ等の肌のトラブル等は実施例、比較例のいずれにおいても全く無かった。
<N-パルミトイル-Gly-Hisゲル凍結・解凍ゲルシートの調製>
上記で合成したN-パルミトイル-Gly-His0.1g、PVA(和光純薬工業(株)製、平均重合度n=1,500~1,800)1g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)8.9gをスクリュー管((株)マルエム製、No.5)に加え、ドライ・バス・インキュベーター(First Gene社製)で加熱(90℃、60分)溶解し、10mLをペトリシャーレ(直径85mm×高さ15mm)に移して静置放冷した。15時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。次いで、このゲルを-20℃にて15時間凍結させた後、1時間室温で解凍して、半透明状のゲルシートを得た。
PVA(和光純薬工業(株)製、平均重合度n=1,500~1,800)1g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)8.8gをスクリュー管((株)マルエム製、No.5)に加え、ドライ・バス・インキュベーター(First Gene社製)で加熱(90℃、60分)溶解し、10mLをペトリシャーレ(直径85mm×高さ15mm)に移して静置放冷した。15時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。次いで、このゲルをー20℃にて15時間凍結させた後、1時間室温で解凍して、透明状のゲルを得た。
ネンブタール(大日本住友製薬(株)製、1.3μL/g筋肉内投与)麻酔下に、ddy系雄性マウス(九動(株)、5週齢、n=8)の背部を徐毛後、エタノール消毒した医療用ハサミでマウス背部の表皮を剥離して直径約10mmの円状の創を作成した。次いで、創傷面の全体に被覆材として、N-パルミトイル-Gly-Hisゲル凍結・解凍シート、ハイドロコロイド素材(キズパワーパッド、ジョンソン・エンド・ジョンソン(株)製)、PVA架橋ハイドロゲル(ビューゲル、ニチバン(株)製)又はPVAゲル凍結・解凍ゲルを被覆させ、さらにその上から粘着式布絆創膏(ニチバン(株)製)を巻き、各被覆材がはがれないように被覆させた。
各被覆材を2日毎に交換し、治癒効果を解析した。解析は、画像処理ソフトウェアImage Jでの創傷面積解析および50%創傷治癒日数解析および病理組織の評価を行い、各被覆材の創傷治癒効果を確認した。尚、創傷面積解析における統計計算は、マイクロソフト オフィス エクセル 2003を用いて、t-検定(一対の標本による平均の検定ツール)を実施しP<0.05を統計的有意差とした。得られた結果を図13及び図14に示す。なお、図13中、統計的有意差があるものに*を付した。
また図14に示すように、50%創傷治癒平均日数は、PVAゲル凍結・解凍ゲル、ハイドロコロイド素材、PVA架橋ハイドロゲルに比べてN-パルミトイル-Gly-Hisゲル凍結・解凍シートが最も短期間であった。
以上の結果より、N-パルミトイル-Gly-Hisゲル凍結・解凍シートが創傷被覆基材として有用であり、これを用いることで創傷の早期の治癒が期待できることが考えられる。
凍結ミクロトーム(Leica製、CM1510)を用いて、正常マウスの皮膚、並びに、実施例31で創傷モデルに用いた4群のマウス(N-パルミトイル-Gly-Hisゲル凍結・解凍シート被覆、ハイドロコロイド素材被覆、PVA架橋ハイドロゲル被覆、PVAゲル凍結・解凍ゲル被覆)の被覆処置4日後のマウス皮膚の凍結切片(8μm)を作成し、マイヤーヘマトキシリン溶液(和光純薬工業(株)製)にて4分間染色後水洗浄、1%エオシンY液(和光純薬工業(株)製)にて1分染色後水洗浄を行い、95%エタノールおよび99%エタノールで脱水後封入のヘマトキシリン・エオシン染色(HE染色)を行い、倒立型システム顕微鏡(オリンパス(株)製、IX70)にて顕微鏡観察解析を行った。得られた結果を図15(正常マウス皮膚)及び図16(創傷モデル被覆処置4日の皮膚)に示す。
図15に示すように、正常マウスの正常皮膚HE染色顕微鏡観察像では、角質層、表皮の顆粒層および有棘層が観察される。
ここで、図16に示す創傷・被覆処置後4日後のマウス創傷皮膚病理像(HE染色顕微鏡観察像)を観察すると、N-パルミトイル-Gly-His凍結ゲル・解凍ゲルシートで被覆した皮膚(図16(A))では角質層の成長が見られ、肉芽も成長し、正常皮膚類似の像が得られた。他方、PVAゲル凍結・解凍ゲル(B)では、顆粒層から上層へ細胞が移動し、角質化が進み始める状態、ハイドロコロイド素材(C)では、角質層は全く形成されておらず、PVA架橋ハイドロゲル(D)では、顆粒層から上層へ細胞が移動し、角質化が進み始める像が得られた。
これらの観察においても、N-パルミトイル-Gly-His凍結ゲル・解凍シートでは、創傷部位の皮膚再生が速いことが確認された。
<N-パルミトイル-Gly-Hisゲルとモルモット保存血液の混合試料の調製>
上記で合成したN-パルミトイル-Gly-His0.3g、及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)9.7gをスクリュー管((株)マルエム製、No.5)に加え、アルミブロック恒温槽(タイテック(株)製)で加熱(90℃、60分)溶解し、室温で静置放冷した。15時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。次いで、スクリュー管内に作製されたゲルの中央部分に直径7mm、深さ5mmの穴を空けた。モルモット保存血液150μlをこの穴に滴下し、室温下にて一晩静置し、後述する血液の凝固状態の評価に用いた。
尚、モルモット保存血液((株)日本バイオテスト研究所製)は、無菌的に採血後、直ちに凝固を抑制する保存液(クエン酸5.5g、クエン酸ナトリウム80g、塩化ナトリウム42、ブドウ糖205g、精製水10L)と血液の量が1:1に混合して調製されている。
CMC(和光純薬工業(株)製)1g及び50mMリン酸緩衝液(和光純薬工業(株)製、pH=7.4)9gをスクリュー管((株)マルエム製、No.5)に加え、アルミブロック恒温槽(タイテック(株)製)で加熱(90℃、120分)分散し、室温で静置放冷した。15時間後、ゲル化を倒置法により確認した。この際、流動性がなくなった状態をゲルと判定した。次いで、スクリュー管内に作製されたゲルの中央部分に直径7mm、深さ5mmの穴を空けた。モルモット保存血液150μlをこの穴に滴下し、室温下にて一晩静置し、後述する血液の凝固状態の評価に用いた。
また図18に示すように、SEM観察では、N-パルミトイル-Gly-Hisゲルを構成するファイバー構造への血球成分の癒着が観察された。
これらの結果より、N-パルミトイル-Gly-Hisゲルを構成するファイバー構造によって、血球成分がファイバー間に物理的にトラップされ、これにより創傷部位での免疫環境が制御されることとなり、これは、例えば、免疫反応による過剰な炎症反応制御や炎症性細胞機能のコントロールなど、皮膚の再生を早める作用をN-パルミトイル-Gly-Hisゲルが有することを示唆するものであった。
Claims (23)
- 分子量が1,000以下である低分子脂質ペプチド又はその薬学的に使用可能な塩からなる脂質ペプチド型ゲル化剤と、高分子化合物とを含むゲルシートであって、
前記高分子化合物が、該ゲルシートの全質量に対して1%(w/w)を超え50%(w/w)未満の量で含まれてなる、ゲルシート。 - 前記高分子化合物が、該ゲルシートの全質量に対して2%(w/w)乃至20%(w/w)の量で含まれてなる、請求項1記載のゲルシート。
- 前記高分子化合物が、ヒドロキシ基を有する直鎖状高分子化合物又は多糖類から選択される、請求項1に記載のゲルシート。
- 前記高分子化合物が、ポリビニルアルコール、アラビアガム又はゼラチンである、請求項3に記載のゲルシート。
- 前記低分子脂質ペプチドが下記式(1)で表される脂質ペプチド又はその薬学的に使用可能な塩である、請求項1に記載のゲルシート。
R2及びR3は、それぞれ独立して、水素原子、メチル基、エチル基、炭素原子数1乃至3の分枝鎖を有し得る炭素原子数3乃至7のアルキル基、フェニルメチル基、フェニルエチル基、又は-(CH2)n-X基を表し、且つR2又はR3のうち少なくとも一つが-(CH2)n-X基を表し、
nは1乃至4の数を表し、Xはアミノ基、グアニジノ基、カルバモイル基、又は窒素原子を1乃至3個有し得る5員環式基若しくは6員環式基、又は5員環と6員環から構成される縮合複素環式基を表し、
mは1乃至3の整数を表す。) - 前記R2は、水素原子、メチル基、i-プロピル基、i-ブチル基、又はsec-ブチル基を表す、請求項5に記載のゲルシート。
- 前記R3は、4-アミノブチル基、4-イミダゾールメチル基、カルバモイルメチル基、2-カルバモイルエチル基、又は3-インドールメチル基を表す、請求項5に記載のゲルシート。
- 前記R1は、炭素原子数13乃至17の脂肪族基を表し、
前記R2は、水素原子、メチル基、又はi-プロピル基を表し、及び
前記R3は、4-アミノブチル基、4-イミダゾールメチル基、又は3-メチルインドール基を表す、請求項5に記載のゲルシート。 - 前記R2は、水素原子を表し、及び
前記R3は、4-イミダゾールメチル基を表す、請求項5に記載のゲルシート。 - 水、アルコール、多価アルコール、親水性有機溶剤、疎水性有機溶剤、又はこれらのうちの2種以上からなる混和溶液を含む、請求項1乃至請求項9のうちいずれか1項に記載のゲルシート。
- 水、又は水と、アルコール、多価アルコール、油脂、シリコーン油及びエステル系溶剤からなる群から選択される1種以上とからなる混和溶液を含む、請求項10に記載のゲルシート。
- 水、又は水と、エタノール、2-プロパノール、オレイルアルコール、フェノキシアルコール、グリセリン、プロピレングリコール、ポリエチレングリコール、1,3-ブタンジオール、アクアホホバオイル、ひまし油、オリーブ油、シリコーン油及びアルギン酸プロピレングリコールエステルからなる群から選択される1種以上とからなる混和溶液を含む、請求項11に記載のゲルシート。
- 多価アルコール、又は、多価アルコールと、アルコール、油脂、シリコーン油、及びエステル系溶剤からなる群から選択される1種以上とからなる混和溶液を含む、請求項10に記載のゲルシート。
- グリセリン、プロピレングリコール、ポリエチレングリコール及び1,3-ブタンジオールからなる群から選択される1種以上の多価アルコール、又は、該多価アルコールのうちの少なくとも1種と、エタノール、2-プロパノール、オレオイルアルコール、フェノキシアルコール、アクアホホバオイル、ひまし油、オリーブ油、シリコーン油、及びアルギン酸プロピレングリコールエステルからなる群から選択される1種以上とからなる混和溶液を含む、請求項13に記載のゲルシート。
- 水と、乳酸カリウム、乳酸ナトリウム及び乳酸カルシウムからなる群から選択される乳酸塩の一種とを含む溶液を含む、請求項10に記載のゲルシート。
- さらにグリセリン、プロピレングリコール、ポリエチレングリコール及び1,3-ブチレングリコールからなる群から選択される1種以上の多価アルコールを含む、請求項15に記載のゲルシート。
- 請求項1乃至請求項16のうちいずれか一項に記載のゲルシートと該シートに重ねられる支持体として不織布、フィルム又はフォームとを有する、積層体。
- 前記ゲルシートの、支持体と反対側の表面に重ねられる剥離フィルムをさらに備える、請求項17記載の積層体。
- 前記支持体が、ポリウレタン、PVA、ポリプロピレン、セルロース又はこれらの積層支持体から選択されるものである、請求項17に記載の積層体。
- 創傷被覆シートである、請求項1乃至請求項16のうちいずれか一項に記載のゲルシート。
- 皮膚保護シート、皮膚ケアーシートである、請求項1乃至請求項16のうちいずれか一項に記載のゲルシート。
- 創傷被覆材の用途に使用される、請求項17乃至請求項19のうちいずれか一項に記載の積層体。
- 皮膚保護シート、皮膚ケアーシートの用途に使用される、請求項17乃至請求項19のうちいずれか一項に記載の積層体。
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US9480772B2 (en) | 2016-11-01 |
EP2638921B1 (en) | 2018-04-25 |
US20130296761A1 (en) | 2013-11-07 |
JP5904949B2 (ja) | 2016-04-20 |
KR101847385B1 (ko) | 2018-04-10 |
CN103313732A (zh) | 2013-09-18 |
CN103313732B (zh) | 2017-07-25 |
EP2638921A4 (en) | 2015-07-22 |
KR20140091648A (ko) | 2014-07-22 |
JPWO2012063947A1 (ja) | 2014-05-12 |
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