WO2011125136A1 - 白内障手術練習用模擬水晶体 - Google Patents
白内障手術練習用模擬水晶体 Download PDFInfo
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- WO2011125136A1 WO2011125136A1 PCT/JP2010/002630 JP2010002630W WO2011125136A1 WO 2011125136 A1 WO2011125136 A1 WO 2011125136A1 JP 2010002630 W JP2010002630 W JP 2010002630W WO 2011125136 A1 WO2011125136 A1 WO 2011125136A1
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
- G09B23/30—Anatomical models
- G09B23/34—Anatomical models with removable parts
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- the simulated core of “Kitataro Wet Lab” is prepared by boiling agar with water on the spot to make an agar solution and sucking it with a syringe into a plastic cup.
- the simulated cortex of the simulated lens of “Kitataro Wet Lab” is made of starch paste.
- the simulated anterior lens capsule is made of a PET film having a thickness of 5 ⁇ m, and the simulated posterior lens capsule is made of a hard plastic having a certain shape.
- the simulated crystalline lens used in this “Kitataro Wet Lab” has a simulated anterior capsule, simulated cortex, and simulated nucleus, so simulation training that is much closer to human eye surgery than other simulated eye apparatus for surgical practice Can do.
- the simulated cortex made of starch paste when the simulated nucleus is emulsified and sucked by the surgical apparatus, the simulated cortex is easily sucked by the surgical apparatus together with the simulated nucleus. For this reason, the simulated nucleus could not be held in the center of the simulated lens through the emulsification and suction operation, and the simulated nucleus could move freely and practice surgery could not be effectively performed.
- the water flow separation that is always performed before the ultrasonic emulsification and suction operation of the nucleus is an operation of injecting water into the nucleus portion, the cortex portion, and the lens capsule portion, but it is a simulated cortex made of starch paste.
- a simulated lens according to the second aspect of the present invention comprises a simulated nucleus corresponding to a human eye lens nucleus and a simulated cortex corresponding to a human eye lens cortex, wherein the simulated nucleus is cheese. Alternatively, it is composed of a cheese-like substance, and the simulated cortex is composed of pulp fibers.
- the cheese or cheese-like substance is based on the total weight of 25 to 50% by weight of water and 10 to 50% of protein. And containing fat in amounts ranging from 10 to 40% by weight.
- the protein contained in cheese or a cheese-like substance contains casein protein, and the submicelle of casein protein forms a network structure.
- the simulated crystalline lens of this embodiment can have a simulated nucleus that exhibits a hardness of 2 to 4 degrees in the Emery nucleus hardness classification.
- the simulated anterior capsular film and the simulated posterior capsular film each have a thickness of 4 to 45 ⁇ m, preferably a thickness of 4 to 4, mainly composed of a material selected from the group consisting of agar, polyethylene terephthalate, orientated polypropylene and cellophane. It can be composed of a 20 ⁇ m film.
- a simulated eye apparatus for practicing cataract surgery comprises: a lower member having a recess opened upward with a circular opening; and detachable from the lower member An upper member to be connected, the upper member having at least an annular portion; the simulated crystalline lens of the first or second aspect of the present invention housed in the recess; the lower member and the upper member; A simulated anterior capsule film made of a film having properties similar to those of a human eye lens anterior capsule; and the simulated anterior capsule film in contact with the simulated lens And tension applying means for applying a tension that is uniform over 360 ° and approximates the anterior lens capsule of the human eye.
- the simulated lens of the present invention can be installed in a simulated eyeball part of a simulated eye apparatus for practicing cataract surgery.
- surgical steps such as continuous circular anterior capsulotomy (CCC), water flow separation between the lens capsule and the lens nucleus, grooving / splitting procedure of the nucleus with an ultrasonic cataract surgical device, nuclear emulsification suction, and cortical suction can be simulated with a feeling very similar to human eye surgery.
- CCC continuous circular anterior capsulotomy
- water flow separation between the lens capsule and the lens nucleus grooving / splitting procedure of the nucleus with an ultrasonic cataract surgical device
- nuclear emulsification suction nuclear emulsification suction
- cortical suction cortical suction
- One form of the simulated lens of the present invention includes at least a simulated nucleus corresponding to the human eye lens nucleus and a simulated cortex corresponding to the human eye lens cortex.
- Another form of the simulated lens of the present invention further includes a simulated anterior capsule and a simulated posterior capsule partially corresponding to the human eye lens capsule.
- FIG. 1 is a cross-sectional view showing first and second embodiments of the simulated crystalline lens of the present invention.
- 10 is a simulated nucleus corresponding to the human eye lens nucleus
- 20 is a simulated cortex corresponding to the human eye lens cortex.
- the simulated nucleus 10 is arranged in the simulated cortex 20.
- the simulated crystalline lens 100 according to the first embodiment of the present invention includes an agar gel simulated nucleus 10 having a specific agar concentration and an agar gel simulated cortex 20 having a specific agar concentration.
- the simulated crystalline lens 100 according to the second embodiment of the present invention includes a simulated nucleus 10 made of cheese or a cheese-like substance and a simulated cortex 20 made of pulp fiber. Below, selection and combination of those materials are demonstrated. I-1. Simulated nucleus 10
- natural cheese was processed into processed cheese. That is, the crushed natural cheese was added to water in which a molten salt was dissolved, and was heated and stirred to be homogeneously melted. This was gradually cooled and then dried to adjust the moisture, thereby producing a processed cheese.
- a molten salt As an example, 0.08 parts by weight of sodium diphosphate as a molten salt is added to 0.4 parts by weight of water and dissolved, and then 1.6 parts by weight of natural cheese pulverized with a grater is added. The mixture was heated and stirred at 90 ° C.
- preservatives can optionally be added to provide longer term quality stability.
- a preservative for example, sorbic acid or dehydroacetic acid dissolved in ethanol can be added at the final stage of heating and stirring, but the preservative and timing that can be added are not limited thereto.
- the process cheese of the present invention can be produced by heating and dissolving one or more natural cheeses by cooling and solidifying them by a general method in the technical field of cheese manufacture. By the above process, the quality of cheese can be controlled, and it has become possible to produce process cheese having the desired hardness using various natural cheese raw materials.
- the simulated nucleus of the present invention made of cheese or cheese-like material exhibits a performance that approximates the human eye lens nucleus for splitting, emulsifying suction, and the like.
- a simulated cortex made of agar gel with an agar concentration of 0.5 to 1.5% by weight, which showed good performance in combination with the agar gel simulated nucleus, was formed to form a simulated lens. Evaluated.
- the simulated nucleus 10 is cheese or a cheese-like substance.
- the cheese may be natural cheese or processed cheese, but if the simulated core 10 is not used immediately after the formation of the simulated core 10, the processed cheese is used instead of natural cheese in terms of quality stability. It is preferable.
- the simulated nucleus 10 made of cheese or cheese-like substance is covered with a simulated cortex 20 made of pulp fiber, and preferably the simulated nucleus 10 is arranged at the center of the simulated cortex 20. According to this embodiment, a simulated crystalline lens having simulated nuclei that are moderately to high in hardness and having a value of 2 to 4 degrees in the emery nucleus hardness classification is obtained.
- the simulated crystalline lens 100 obtained by combining these can be provided with storage stability by various means in order to further enhance storage stability until use.
- a preservative can be added during the production process.
- the produced simulated crystalline lens 100 can be vacuum-packed in a plastic case, and an oxygen scavenger such as AGELESS (registered trademark) can be further enclosed.
- the simulated anterior capsule is composed of a film as in the third embodiment, but the simulated posterior capsule is composed of a cup member having a certain shape (hereinafter, a simulated posterior capsule made of a cup member is referred to as “ Simulated posterior capsule member ”).
- Simulated posterior capsule member a cup member having a certain shape
- the size of the simulated lens is shown to be equivalent to the size of the human eye lens (lens shape with a diameter of about 9 to 10 mm and the maximum thickness of about 4 mm), but this size is used by the simulated lens. It will be understood that it varies depending on the simulated eye apparatus for practicing cataract surgery.
- the simulated crystalline lens 110 has a soft core to a hard core from CCC, water flow separation, various techniques of nuclear splitting, nuclear emulsification suction, cortical suction, and even intraocular lens insertion. All the steps of the ultrasonic cataract surgery on the artificial cataract lens can be performed with a sense very similar to that of human eye surgery. Further, by using the specific film for the simulated posterior capsule, intraoperative complications such as posterior capsule damage and subsequent nuclear dropping can be simulated, and it is also possible to learn complication treatment. (3) Simulated posterior cup member 32
- FIGS. 11A and 11B show one form in which the simulated eye 70 is not a hemisphere but a sphere.
- 11A is a cross-sectional view in a normal state
- FIG. 11B is a cross-sectional view after turning.
- a magnet 200 is installed on the bottom wall 98 of the lower member 90 formed in a spherical shape opposite to the corneal apex 70p so that the direction Z of the magnetic force line passes through the corneal apex 70p, and the cylindrical elastic If the member 230 is disposed around the iron ball 210 between the spherical bottom wall 98 and the pedestal 220, the same effect as in the case of the hemispherical simulated eye 70 can be obtained. However, at this time, the turning radius of the spherical simulated eye 70 is slightly increased.
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Abstract
Description
I.本発明の模擬水晶体の構造と材質
I-1.模擬核10
(1)寒天ゲル製模擬核
(2)チーズまたはチーズ様物質製模擬核
I-2.模擬皮質20
(1)寒天ゲル製模擬皮質
(2)模擬核10と寒天ゲル製模擬皮質との組み合わせ
(2)-1.寒天ゲル製模擬核と寒天ゲル製模擬皮質との組み合わせ
(2)-2.チーズまたはチーズ様物質製模擬核と寒天ゲル製模擬皮質との組み合わせ
(3)パルプ繊維製模擬皮質
I-3.模擬水晶体嚢
(1)模擬前嚢フィルム40
(2)模擬後嚢フィルム30
(3)模擬後嚢カップ部材32
II.本発明の模擬水晶体の使用の形態
II-1. 白内障手術練習用模擬眼装置への適用
(1)模擬眼装置
(2)使用の形態
(3)模擬眼装置の変形例
II-2. 販売形態
20 模擬皮質
30 模擬後嚢フィルム
32 模擬後嚢カップ部材
40 模擬前嚢フィルム
50 支持部材
70 模擬眼
80 上側部材
90 下側部材
100、110、120 模擬水晶体
Claims (25)
- 人眼水晶体核に対応する模擬核と、
人眼水晶体皮質に対応する模擬皮質と、
を備え、
前記模擬核は、寒天濃度1.0~5.0重量%の寒天ゲルで構成され、
前記模擬皮質は、前記模擬核を構成する寒天ゲルよりも低い寒天濃度である寒天濃度0.5~1.5重量%の寒天ゲルで構成されている
ことを特徴とする模擬水晶体。 - 前記模擬核は、寒天濃度1.0~3.0重量%の寒天ゲルで構成されることを特徴とする請求項1に記載の模擬水晶体。
- 前記模擬核は、寒天濃度1.0~2.0重量%の寒天ゲルで構成されることを特徴とする請求項1に記載の模擬水晶体。
- 前記模擬核は、エメリー核硬度分類において1度から2度の硬度を有することを特徴とする請求項1から3のいずれかに記載の模擬水晶体。
- 請求項1から4のいずれかに記載の模擬水晶体を製造するための方法であって、
前記模擬核を0~10℃に冷却する工程と、
前記模擬皮質となるべき寒天溶液を調製して35~60℃に温度調節する工程と、
前記寒天溶液中に前記冷却した模擬核を浸漬する工程と、
前記模擬核および前記寒天溶液を、前記寒天溶液がゲル化する温度に冷却する工程と、
を含むことを特徴とする模擬水晶体製造方法。 - 人眼水晶体核に対応する模擬核と、
人眼水晶体皮質に対応する模擬皮質と、
を備え、
前記模擬核は、チーズまたはチーズ様物質で構成され、
前記模擬皮質は、パルプ繊維で構成され
ていることを特徴とする模擬水晶体。 - 前記チーズまたはチーズ様物質は、全重量を基準として、水を25~50重量%、タンパク質を10~50重量%、および脂肪を10~40重量%の範囲の量で含有することを特徴とする請求項6に記載の模擬水晶体。
- 前記タンパク質は、カゼインタンパク質を含有し、前記カゼインタンパク質のサブミセルは網目構造を形成していることを特徴とする請求項7に記載の模擬水晶体。
- 前記模擬核は、エメリー核硬度分類において2度から4度の硬度を有することを特徴とする請求項6から8のいずれかに記載の模擬水晶体。
- 人眼水晶体後嚢と近似する性質を有する模擬後嚢フィルムと、
人眼水晶体前嚢と近似する性質を有する模擬前嚢フィルムと、
をさらに備えていることを特徴とする、請求項1から4および6から9のいずれかに記載の模擬水晶体。 - 前記模擬前嚢フィルムおよび前記模擬後嚢フィルムは、それぞれ、寒天、ポリエチレンテレフタレート、オリエンティッドポリプロピレンおよびセロハンからなる群から選択される材料を主成分とする厚さ4~45μmのフィルムで構成されることを特徴とする請求項10に記載の模擬水晶体。
- 前記模擬前嚢フィルムは、ポリエチレンテレフタレートを主成分とする厚さ4~20μmのフィルムであることを特徴とする請求項10に記載の模擬水晶体。
- 前記模擬前嚢フィルムと前記模擬後嚢フィルムとの接合部の下方に支持部材をさらに備えていることを特徴とする請求項10から12のいずれかに記載の模擬水晶体。
- 人眼水晶体後嚢に対応する形状を有する模擬後嚢カップ部材と、
人眼水晶体前嚢と近似する性質を有する模擬前嚢フィルムと、
をさらに備えていることを特徴とする、請求項1から4および6から9のいずれかに記載の模擬水晶体。 - 前記模擬前嚢フィルムは、寒天、ポリエチレンテレフタレート、オリエンティッドポリプロピレンおよびセロハンからなる群から選択される材料を主成分とする厚さ4~45μmのフィルムで構成されることを特徴とする請求項14に記載の模擬水晶体。
- 前記模擬前嚢フィルムは、ポリエチレンテレフタレートを主成分とする厚さ4~20μmのフィルムであることを特徴とする請求項14に記載の模擬水晶体。
- 上方が円形の開口部で開口されたくぼみを有する下側部材と、
該下側部材に取外し可能に連結される上側部材であって、少なくとも円環状部を有する上側部材と、
前記くぼみに収容される、請求項1から4および6から9のいずれかに記載の模擬水晶体と、
前記下側部材と前記上側部材との間に配設される、人眼水晶体前嚢と近似する性質を有するフィルムで構成された模擬前嚢フィルムと、
前記模擬前嚢フィルムが前記模擬水晶体に接触した状態で、前記模擬前嚢フィルムに360°にわたって均一で人眼水晶体前嚢と近似する張力を付与する張力付与手段と、
を備えることを特徴とする白内障手術練習用模擬眼装置。 - 前記模擬前嚢フィルムは、寒天、ポリエチレンテレフタレート、オリエンティッドポリプロピレンおよびセロハンからなる群から選択される材料を主成分とする厚さ4~45μmのフィルムで構成されることを特徴とする請求項17に記載の白内障手術練習用模擬眼装置。
- 前記模擬前嚢フィルムは、ポリエチレンテレフタレートを主成分とする厚さ4~20μmのフィルムであることを特徴とする請求項17に記載の白内障手術練習用模擬眼装置。
- 上方が円形の開口部で開口されたくぼみを有する下側部材と、
該下側部材に取外し可能に連結される上側部材であって、少なくとも円環状部を有する上側部材と、
前記くぼみに収容される、請求項10から16のいずれかに記載の模擬水晶体と、
前記模擬前嚢フィルムに360°にわたって均一で人眼水晶体前嚢と近似する張力を付与する張力付与手段と、
を備えることを特徴とする白内障手術練習用模擬眼装置。 - 前記上側部材の前記円環状部に、少なくとも1つの器具挿入用孔が形成されていることを特徴とする請求項17または20に記載の白内障手術練習用模擬眼装置。
- 前記上側部材の前記円環状部に取り付けられ、人眼角膜または強膜と近似する性質を有する材料で構成される模擬角膜または模擬強膜をさらに備えることを特徴とする請求項17から21のいずれかに記載の白内障手術練習用模擬眼装置。
- 前記模擬角膜または模擬強膜は、人眼角膜に対応するドーム形状を有していることを特徴とする請求項22に記載の白内障手術練習用模擬眼装置。
- 前記人眼角膜または強膜と近似する性質を有する材料は、TPR、シリコン樹脂、軟質塩化ビニル樹脂、ハイドロジェル、軟性アクリル樹脂からなる群から選択される材料であることを特徴とする請求項22または23に記載の白内障手術練習用模擬眼装置。
- 磁力線の方向が視線の向きとほぼ一致するように、前記下側部材に組み込まれた磁石と、
少なくとも前記磁石に当接する面が凸状の湾曲面に形成され、台座に固定された磁性体と、
をさらに備えることを特徴とする請求項17から24のいずれかに記載の白内障手術練習用模擬眼装置。
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PCT/JP2010/002630 WO2011125136A1 (ja) | 2010-04-09 | 2010-04-09 | 白内障手術練習用模擬水晶体 |
JP2012509194A JP5311359B2 (ja) | 2010-04-09 | 2010-04-09 | 白内障手術練習用模擬水晶体 |
US13/640,279 US8821166B2 (en) | 2010-04-09 | 2010-04-09 | Artificial lens for cataract surgery practice |
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Also Published As
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JPWO2011125136A1 (ja) | 2013-07-11 |
US20130030524A1 (en) | 2013-01-31 |
JP5311359B2 (ja) | 2013-10-09 |
US8821166B2 (en) | 2014-09-02 |
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