WO2011074921A2

WO2011074921A2 - Composition for alleviating atopic dermatitis and a preparation method of the same

Info

Publication number: WO2011074921A2
Application number: PCT/KR2010/009089
Authority: WO
Inventors: 하경윤
Original assignee: Ha Kyoung-Yoon
Priority date: 2009-12-18
Filing date: 2010-12-17
Publication date: 2011-06-23
Also published as: WO2011074921A3

Abstract

The present invention relates to a composition for alleviating atopic dermatitis and a method for preparing the same. More specifically, the present invention relates to a composition and a preparation method for alleviating atopic dermatitis, which has a moisturizing and an antimicrobial function that suppress an induction of atopic dermatitis and prevent and cure atopic dermatitis, and which is able to activate skin by forming an oil coating on skin as well. The present invention is characterized by comprising: 11~15 wt% of pleuropterus multiflorus heated three times in honey at 80ºC for 90 minutes; 15~21 wt% of angelica gigantis radix heated two times in rice water at 80ºC for 90 minutes; 5~7 wt% of Cnidium officinale heated submerged in Japanese apricot concentrate for 24 hours; 11 ~ 15 wt% of Chaenomeles sinensis; 5~7 wt% of Crataegi fructus heated in milk at 80ºC for 90 minutes; 0.5~1 wt% of Eucommia ulmoides oliver roasted for 5 minutes; 0.5~1 wt% of earthworm; a small amount of sugar.

Description

Composition for relieving atopic dermatitis and preparation method thereof

The present invention relates to a composition for relieving atopic dermatitis and a method for manufacturing the same, and more particularly, to form an oil film on the skin as well as a moisturizing function and antibacterial function to inhibit the occurrence of atopic dermatitis and prevent and cure atopic dermatitis. The present invention relates to a composition for alleviating atopic dermatitis and a method for producing the same that can activate skin.

In general, atopic dermatitis is caused by a decrease in the content of ceramides in the stratum corneum due to genetic, environmental, and immunological causes. It is an allergic disease that occurs.

Such atopic dermatitis, as the immune function of the skin is lowered, stimulates the stimulus substance into the stratum corneum, causing irritation, and it is difficult to endure the symptoms of tickling as the invasion of the house protein, which is difficult to invade in normal skin.

Severe scratching of these atopy skin is accompanied by eczema, keloids and severe keratinization.

Although the cause of atopic skin is not well known, it appears to be caused by a combination of immune system deficiency, environmental factors, production of lipid peroxide by free radicals, infection of bacteria, viruses, and fungi.

In order to improve the atopic skin, in principle, it cleans the skin, removes substances that can act as antigens, strengthens the skin barrier function, and supplies ceramide, an intercellular lipid component that is insufficient to protect the skin from drying, and irritates the stratum corneum. It has been used to avoid physical stimuli.

Thus, the prescription for atopic dermatitis may include ingredients such as known ceramides, liroleic acid, vegetable oils or mineral oils, steroid preparations such as idrocortisone, and certain plant extracts in the formulation of general emulsified products or It is mainly used in the form of liposomes using lecithin and supplied to the stratum corneum to create an oil film to prevent moisturizing effect and water loss and to prevent bacterial contamination.

These methods have anti-inflammatory and immunosuppressive effects in the prevention and treatment of atopy skin and have some results.However, when applied for a long time, the use of steroids can cause adverse effects such as growth inhibition and side effects of the epidermis and urea peroxide. The back may cause skin irritation and other contact dermatitis, and antibiotics such as antihistamines may have side effects such as bacterial resistance and photosensitive effects.

In order to prevent these side effects, many effective compositions for atopy using medicinal extracts have been provided, but the effect was insignificant.

One object of the present invention is a skin moisturizing effect that prevents the epidermal tissue from keratinizing by preventing the drying of the stratum corneum due to moisture loss, antibacterial effect to remove the bacteria contaminated on the skin and prevent contamination and regenerating the skin It is to provide a composition for alleviating atopic dermatitis.

Another object of the present invention is to provide a method for preparing a composition for alleviating atopic dermatitis.

The composition for alleviating atopic dermatitis according to the present invention for achieving the above object is 11 to 15% by weight of sewage, which is repeated three times of heating at 80 degrees for 90 minutes in honey, and put in rice water to 90 degrees at 90 degrees. 15 ~ 21% by weight of Angelica, which was repeatedly heated for 2 minutes, 5 ~ 7% by weight of cheongung immersed in plum extract for 24 hours, 11 ~ 15% by weight of quince and put into milk and heated at 80 ° C for 90 minutes 5 to 7% by weight, 0.5 to 1% by weight of roasted tofu, 5 to 11% by weight of earthworm, characterized in that it comprises a residual amount of sugar.

In addition, based on 100 parts by weight of the composition, 5 to 7 parts by weight, 5 to 7 parts by weight of hemp and 5 to 7 parts by weight of cinecin may be further included.

A method for preparing a composition for atopic dermatitis relief according to the present invention for achieving the above another object is a sewage preparation step of repeating boiled and cooled three times for 90 minutes at a temperature of 80 ° C. in a state where sewage roots are put in honey, and the water of the donkey Put it in a boiled and cooled for 80 minutes at 80 degrees, repeat the donkey preparation step, prepare the cheonggung soaked in plum extract for 24 hours, and prepare the cheongung soaked in plum extract, and slice the quince into a certain size The stage of preparation of quince, the stage of preparation of hawthorn which is boiled and cooled for 90 minutes at a temperature of 80 degrees while the hawthorn is put in milk, the stage of preparation of chopped tofu for 5 minutes, and the sewage 11 to 15% by weight, donkey 15 to 21 5% by weight, 5-7% by weight, 11-15% by weight quince, 5-7% by weight of hawthorn, 0.5-1% by weight of worms, 11-15% by weight of earthworm, and the remaining sugar When sealed The sealing step, sterilization step of cooling by heating and sterilizing the closed container of the sealed step in water of 60 ~ 80 degrees for 15 to 20 minutes, and the aging step of aging the sterilized closed container at a temperature of 2 ~ 4 degrees for 100 days Characterized in that it comprises a.

The present invention is to increase the moisturizing effect to prevent the dead skin caused by atopic dermatitis and to form an oil film for protecting the skin and antibacterial effect to prevent the growth of bacteria can be cured and prevented atopic dermatitis It works.

1 is a process flowchart showing a method for preparing a composition for atopic dermatitis relief according to the present invention.

Advantages and features of the present invention and methods for achieving them will be apparent with reference to the embodiments described below in detail with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but may be implemented in various different forms, only the present embodiments to make the disclosure of the present invention complete, and common knowledge in the art to which the present invention pertains. It is provided to fully inform the person having the scope of the invention, which is defined only by the scope of the claims. Like reference numerals refer to like elements throughout.

Hereinafter, a composition for atopic dermatitis relief and a manufacturing method thereof according to the present invention will be described with reference to the accompanying drawings.

아토피 피부염 완화를 위한 조성물Composition for Relieving Atopic Dermatitis

The composition for alleviating atopic dermatitis according to the present invention is 11 to 15% by weight of sewage, 15 to 21% by weight, Angelica 5 to 7% by weight, quince 11 to 15% by weight, hawthorn 5 to 7% by weight and , 0.5 to 1% by weight, earthworm 11 to 15% by weight, and the balance of sugar.

Sewage in the composition is a reddish brown tuber root used as a tonic, tonicity, and emollient and also used to absorb pus.

The sewage serves as a preservative and is added to honey, which is used for preservation of the fruit, and heated three times at 80 degrees for 90 minutes, thereby making the sewage into a gel state.

In addition, the blood-reducing blood activity and blood circulation and blood-sucking action and anti-cancer effect is strong blood pressure lowering action to promote the blood flow of the coronary arteries, red blood cells to promote the blood flow to remove the bitter taste and soften the properties In order to do this, put the rice water and heat it at 80 degrees for 90 minutes twice so that the Angelica is also gelled.

And scented aroma plant, soothing, analgesic, and soy sauce, soaked in the extract of plum, rich in minerals, vitamins and organic acids and excellent in detoxification for 24 hours, soaking plum extract.

On the other hand, there are many organic acids, chop the quince to improve metabolism, put the sansa to promote digestion in milk and heat to 80 degrees for 90 minutes to maintain the gel state.

In addition, the bark of the bark to control the humectants are fried for 5 minutes to break down the fiber and mixed with sugar to prevent the deterioration of each raw material and extract the ingredients of earthworms used in cosmetics as a moisturizer as a circular animal.

At this time, analgesic, jingyeong, tonic action and yulmu, tonic, gangjeong, the branch used as a branch, sedation, analgesic, anti-inflammatory, immunosuppressive sessin can be further aged.

Referring to Figure 1, the composition preparation method for atopic dermatitis relief according to the present invention includes a raw material preparation step (S110), sealing step (S120), sterilization step (S130) and aging step (S140).

1) Raw material preparation stage

In the raw material preparation step (S110)

Sewage preparation step (S111) that repeats boiled and cooled for 90 minutes at a temperature of 80 degrees while the sewage roots are put in honey, and

The donkey preparation step (S112), which repeats boiled and cooled in 80 minutes at 80 degrees by putting the donkey in water (used water from washing rice),

The preparation step of the archery (S113) to prepare the archery soaked in the plum extract by immersing the arch in the plum extract for 24 hours,

Prepared quince prepared step (S114) by cutting the quince into a certain size,

Sansa prepared step (S115) to boil and cool 90 minutes at a temperature of 80 degrees while putting the hawthorn in milk,

Tofu consists of two stages of stir fry prepared for 5 minutes (S116).

2) sealing stage

In the closed step (S120) 11-15% by weight of the prepared raw material sewage, 15-21% by weight, Angelica 5-7% by weight, quince 11-15% by weight, hawthorn 5-7% by weight, Tofu 0.5 After mixing 1 ~ 15% by weight of earthworm 11-15% by weight of the remaining sugar, and then sealed in a sealed container to prevent corruption.

3) Sterilization Step

In the sterilization step (S130), the sealed container that passed through the sealing step (S120) is sterilized by heating for 15 to 20 minutes in water of 60 to 80 degrees so as not to destroy the components of the raw material.

4) Ripening step

In the aging step (S140), the sterilized hermetic container is aged for 100 days at a temperature of 2 to 4 degrees, but the aging method is put into a separate device capable of maintaining the temperature, but it is determined that it is desirable to bury it in the ground.

The aged raw material is changed into a liquid so as to apply well, it can heal atopic dermatitis by the action of antibacterial, moisturizing, skin protection.

실시예EXAMPLE

Hereinafter, the configuration and operation of the present invention through the preferred embodiment of the present invention will be described in more detail. However, this is presented as a preferred example of the present invention and in no way can not be construed as limiting the present invention.

Details that are not described herein will be omitted since those skilled in the art can sufficiently infer technically.

1. 아토피 피부염 완화를 위한 조성물 제조1. Preparation of composition for alleviation of atopic dermatitis

(Example 1)

The sewage, which is boiled and cooled three times for 90 minutes at 80 ° C with the sewage roots in honey, and the donkey, which has been repeatedly boiled and cooled at 80 ° C for 90 minutes with 80g The cheongung was immersed for 24 hours to prepare a cheongung soaked in plum extract, quince sliced to a size of about 3cm, boiled sansa, boiled and cooled at 80 ° C. for 90 minutes in milk, and roasted tofu for 5 minutes on fire.

Thereafter, sewage 16g, Angelica 19g, Cheongung 7g, Chinese quince 14g, hawthorn 6g, tofu 1g, earthworm 14g and sugar 23g was put in an airtight sealed container, and then stored in the airtight container for two days.

Thereafter, the sealed container was sterilized and cooled by heating in water at 60 ° C. for 15 to 20 minutes, and then, the sterilized closed container was aged at a temperature of 3 ° C. for 100 days to prepare a composition for alleviating atopic dermatitis.

(Example 2)

A composition for atopic dermatitis relief was prepared in the same manner as in Example 1 except for further adding 5 g of yulmu, 6 g of hemp and 5 g of succinate in the airtight container.

(Comparative Example 1)

A composition for alleviating atopic dermatitis was prepared in the same manner as in Example 1 except that 39 g of sugar was added instead of sewage in an airtight container.

(Comparative Example 2)

A composition for alleviating atopic dermatitis was prepared in the same manner as in Example 1, except that 49 g of sugar was added instead of donkey and cheonggung in an airtight container.

(Comparative Example 3)

A composition for alleviating atopic dermatitis was prepared in the same manner as in Example 1 except that 43 g of sugar was added instead of quince and hawthorn in an airtight container.

2. 아토피 피부염 개선 효과 테스트2. Atopic dermatitis improvement effect test

After dividing 10 patients into 5 groups of 50 patients composed of 1 to 20 years of age with atopic dermatitis, the composition for alleviating atopic dermatitis according to Examples 1 and 2 and Comparative Examples 1, 2 and 3 for each group was prepared. After three times a day, the affected group was applied to the affected area for four weeks, and the four groups were treated by the doctor (A) of the seventh year of experience on a weekly basis.

At this time, the treatment scale and the treatment results are shown in Table 1 and Table 2, respectively. (The age and sex ratios of the patients in each group were adjusted to similar levels.)

TABLE 1

TABLE 2

Referring to Tables 1 and 2, in the case of Groups 1 and 2 where the composition for alleviating atopic dermatitis according to Examples 1 and 2 was applied to the affected area, the results measured after one week had passed to Comparative Examples 1,2 and 3 According to the composition for relieving atopic dermatitis, the improvement effect was insignificant compared to the groups 3, 4 and 5 applied to the affected area, but it can be seen that the effect of improving atopic dermatitis is significantly improved compared to the groups 3, 4 and 5 from the third week. In this case, it can be seen that Group 2 has a slight difference, but a slightly superior effect compared to Group 1.

On the other hand, it can be seen that in the case of groups 3, 4 and 5 where the composition for alleviating atopic dermatitis according to Comparative Examples 1, 2 and 3 is applied to the affected area, only 4 weeks have elapsed.

Although the above has been described with reference to the embodiments of the present invention, various changes and modifications can be made at the level of those skilled in the art. Such changes and modifications can be said to belong to the present invention without departing from the scope of the technical idea provided by the present invention. Therefore, the scope of the present invention will be determined by the claims described below.

Claims

11 ~ 15% by weight of sewage, which was repeated three times of heating at 80 ° C for 90 minutes in honey, and 15-21% by weight of Angelica extract, which was repeatedly heated in 80 ° C for 90 minutes twice, and in plum extract. 5 to 7% by weight of horoscopes soaked for 24 hours, 11 to 15% by weight of quince, 5 to 7% by weight of hawthorn put in milk and heated at 80 ° C for 90 minutes, and 0.5 to 1% by weight of worms roasted for 5 minutes, and earthworm 11 to 15% by weight, and a composition for relieving atopic dermatitis, characterized in that it comprises a residual amount of sugar.
The method of claim 1,

For 100 parts by weight of the composition,

5-7 parts by weight of yulmu, 5-7 parts by weight, and 5-7 parts by weight of sessin, the composition for alleviating atopic dermatitis, further comprising.
Sewage preparation step of repeating boiled and cooled for 90 minutes at 80 ° C with the sewage roots in honey,

A donkey preparing step of repeating the donkey in rice water boiled and cooled at 80 degrees for 90 minutes,

A preparation step for preparing the cheongung soaked in ume extract for 24 hours

Prepare the quince prepared by cutting the quince into a certain size,

Sansa preparation step of boiling and cooling 90 minutes at a temperature of 80 degrees while putting the sansa in milk,

Tofu preparation step of roasting tofu on fire for 5 minutes,

11 ~ 15% by weight of sewage, 15-21% by weight of Angelica, 5-7% by weight of horoscope, 11-15% by weight of Chinese quince, 5-7% by weight of hawthorn, and 0.5-1% by weight of worms A sealing step of sealing 15-15% by weight and the remaining amount of sugar in a sealed container;

A sterilization step of sterilizing and cooling by heating the airtight container in the airtight step for 15 to 20 minutes in water of 60 to 80 degrees;

Method for producing a composition for atopic dermatitis relief comprising the aging step of aging the sterilized closed container 100 days at a temperature of 2 ~ 4 degrees.