CN105434279B - A kind of Radix Notoginseng massage cream and preparation method thereof - Google Patents

A kind of Radix Notoginseng massage cream and preparation method thereof Download PDF

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CN105434279B
CN105434279B CN201511029851.XA CN201511029851A CN105434279B CN 105434279 B CN105434279 B CN 105434279B CN 201511029851 A CN201511029851 A CN 201511029851A CN 105434279 B CN105434279 B CN 105434279B
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extract
radix
notoginseng
radix notoginseng
massage cream
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CN105434279A (en
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王萍
罗渝杰
罗开珍
况金妍
周家明
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Yunnan Qianrong Biotechnology Co ltd
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YUNNAN REN XIU HUA COSMETICS Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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Abstract

The present invention relates to a kind of Radix Notoginseng massage cream and its preparation processes, belong to cosmetic field, and the Radix Notoginseng massage cream is made of the traditional Chinese medicinal material raw materials of following weight ratio:Notoginseng essential oil 15~22%, radix-polygoni multiflori extract 10~18%, hawthorn extract 14~16%, green-tea extract 8~10%, sorbierite 8~10%, white oil 8~10%, polyoxyethylene lauryl alcohol ether 3~6%, polysorbate60 0.1~0.3%, methyl hydroxybenzoate 0.1~0.3%, surplus is pure water.The present invention is using the notoginseng essential oil of valuable ingredient of traditional Chinese medicine Radix Notoginseng as primary raw material, it adds in radix-polygoni multiflori extract, hawthorn extract, green-tea extract etc. and carries out rational proportion, the monarch and his subjects' compatibility, synergy, remove facial oiliness, pore is restrained, eliminates facial edema, resisting age of skin, there is preferable prevention and treatment effect to chestnut papule, desalinate freckle, promote the absorption of nutriment, make skin is ruddy to compact.

Description

A kind of Radix Notoginseng massage cream and preparation method thereof
Technical field
The invention belongs to cosmetic field, specifically, being related to a kind of Radix Notoginseng massage cream and preparation method thereof.
Background technology
Skin aging that work growing day by day and life stress, environmental pollution, Seasonal conversion etc. are brought, skin be coarse, It is dim it is mute, etc. skin problem annoying many crowds, as the improvement of people's living standards, people also increasingly pay attention to skin guarantor It supports, the skin care products such as cream, frost, breast, water are flooded with entire Cosmetic Market.
Massage cream coordinates massage manipulation, can play the role of releiving to face, skin of neck, relaxing tendons and activating collaterals contributes to skin Absorption to nutriment accelerates metabolism, promotes toxin expelling.Massage cream type on existing market is various, but depends on unduly The addition of chemical composition, lead, mercury etc. is exceeded, and very big, and protection to skin, repairing effect are injured to skin and health Unobvious, therefore innate efficacy ingredient is used as the massage cream of additive has become a kind of trend.
Invention content
In view of the above-mentioned problems, the present invention proposes a kind of Radix Notoginseng massage cream and preparation method thereof, with the three of valuable ingredient of traditional Chinese medicine Radix Notoginseng Seven volatile oil are primary raw material, add in radix-polygoni multiflori extract, hawthorn extract, green-tea extract etc. and carry out rational proportion, the monarch and his subjects Facial oiliness is removed in compatibility, synergy, restrains pore, eliminates facial edema, and resisting age of skin has chestnut papule preferable Prevention and treatment effect, desalinate freckle, promote the absorption of nutriment, make skin is ruddy to compact.
To solve the above-mentioned problems, present invention employs following technical solutions:
A kind of Radix Notoginseng massage cream, the Radix Notoginseng massage cream are made of the traditional Chinese medicinal material raw materials of following weight ratio:Radix Notoginseng is volatilized Oil 15~22%, radix-polygoni multiflori extract 10~18%, hawthorn extract 14~16%, green-tea extract 8~10%, sorbierite 8 ~10%, white oil 8~10%, polyoxyethylene lauryl alcohol ether 3~6%, Tween-60 0.1~0.3%, methyl hydroxybenzoate 0.1~ 0.3%, surplus is pure water.
A kind of preferred embodiment of Radix Notoginseng massage cream according to the present invention, Radix Notoginseng massage cream by following weight ratio Chinese medicine Material raw material forms:Notoginseng essential oil 20%, radix-polygoni multiflori extract 15%, hawthorn extract 15%, green-tea extract 9%, sorb Alcohol 8%, white oil 8%, polyoxyethylene lauryl alcohol ether 5%, Tween-60 0.2%, methyl hydroxybenzoate 0.2%, surplus is pure water.
The preparation method of above-mentioned Radix Notoginseng massage cream, the specific steps are:
1) pure water of 40% formula ratio and the radix-polygoni multiflori extract of formula ratio, hawthorn extract, green-tea extract is taken to mix It closes uniformly, adds sorbierite, the Tween-60 of formula ratio, boil under normal pressure, and keep fluidized state 20-30 minutes, stand 70-80 DEG C is cooled to, filter to get filtrate A;
2) pure water of 60% formula ratio is taken to be uniformly mixed simultaneously with the notoginseng essential oil of formula ratio, white oil, methyl hydroxybenzoate 70-80 DEG C is heated to, liquor B is obtained by filtration;
3) filtrate A and liquor B are mixed, and the polyoxyethylene lauryl alcohol ether for adding in formula ratio carries out emulsifying, stirring 2000-2400 revs/min of rotating speed is kept for 8-10 minutes, vacuum defoamation;
4) step 3) gains are cooled to 40 DEG C of inspections, pack to get product of the present invention.
Each composition component and effect of this formula is as follows:
《Compendium of Materia Medica》In just describe the outstanding medicinal efficacy of " Radix Notoginseng ", " Radix Notoginseng " is referred to as " invaluable ", " god of hemostasis Medicine, the quality goods of regulating blood condition ".Proved according to modern plants, pharmacology and clinic study, " Radix Notoginseng " with ginseng is equal belongs to, remove Containing refreshing oneself outside whole active ingredients such as nourishing contained by ginseng, also containing a large amount of promoting blood circulation and removing blood stasis, hemostasia and promoting granulations, anti-inflammatory analgesic therapy, The bioactive ingredients of the effects that relaxing tendons and activating collaterals, strengthening by means of tonics.Its active ingredient mainly has notoginsenoside, flavones and volatile oil, Radix Notoginseng can effectively anti-lipid peroxidation and malonaldehyde generation, flavonoids therein can improve antioxidase in cell Bioactivity can promote the synthesis of SOD and GSH-PX enzymes, so as to reduce lipid peroxidation, moreover it is possible to promote blood circulation, make skin Skin is ruddy even bright;Notoginseng essential oil has brain oblongata inhibiting effect, tranquilizing and allaying excitement, and β-elemene therein has antitumaous effect, And there is weak sterilization and bactericidal effect, and locally there is stimulation, it can relaxed muscle.
Radix-polygoni multiflori extract has obviously inhibiting effect, and increasing to the generation of mouse skin lipid peroxide The activity of strong SOD and catalase, eliminate free radical, slow down aging.The study found that fleece-flower root water extract can activate The activity of tyrosinase in B16F1 melanoma cells, and increase the synthetic quantity of melanin, while also have and melanocyte is promoted to increase The effect grown.
Contain abundant organic acid, triterpenic acid, vitamin C, vitamin B in hawthorn2, pectin, procyanidine etc., hawthorn carries Object is taken, which to have, increases coronary flow, improves human body myocardial function, lowering blood pressure and blood fat, anti-oxidant, removing free radical, anti-AIDS The pharmacological actions such as virus.Procyanidine heats in acid medium can generate anthocyanidin, and procyanidine is that one kind has special point The bioflavonoid of minor structure, is the generally acknowledged most effective natural of removing people's interior free yl in the world at present, energy It promotes blood circulation, promotes cell metabolism, mitigate oedema, strengthen capillary, make the drag reduction of capillary and ooze Permeability is improved, and cell is made to be easier to absorb nutrient, excludes waste, and can also enhance ascorbic effect, extends vitamin It is the time that effect occurs in human body for C.
The main component of green-tea extract be tea polyphenols, tea polyphenols can be substantially reduced hyperlipidemia serum total cholesterol, Triglyceride, low density lipoprotein cholesterol content;Facial oiliness is removed, pore is restrained, lipid peroxidation process can be blocked, is risen To anti-mutation, antitumaous effect;There is antibacterial action to the various pathogens for causing diarrhea, respiratory tract and skin infection;Can effectively it press down The normal function of melanocyte is protected in the activation of melanocyte processed, mitigates pigmentation.
Beneficial effects of the present invention:The present invention is extracted using the volatile oil of valuable ingredient of traditional Chinese medicine Radix Notoginseng as primary raw material with the fleece-flower root Object, hawthorn extract, green-tea extract carry out reasonable compatibility, wherein, notoginseng essential oil energy relaxed muscle, releive face, neck Tight feeling;The activity of radix-polygoni multiflori extract energy enhancement of SOD and catalase eliminates free radical, slows down aging;Hawthorn is extracted Liquid energy promotes blood circulation, and mitigates oedema, and cell is made to be easier to absorb nutrient, excludes waste, anti-oxidant;Green-tea extract can hinder Disconnected lipid peroxidation process, has antibacterial action, can effectively inhibit the activation of melanocyte, mitigates pigmentation;Especially, mountain Short, bristly hair or beard extracting solution and green-tea extract compatibility have chestnut papule preferable prevention and treatment effect, realize resisting age of skin, desalination Freckle eliminates facial edema, promotes the absorption of nutriment, make skin is ruddy to compact.Preparation method of the present invention is by controlling work The effect of skill parameter, makes each component uniformly mix, and the property for making product of the present invention is more reliable, active ingredient is preferably sent out It waves.
Specific embodiment
Embodiment 1
1st, raw material proportioning:Notoginseng essential oil 15%, radix-polygoni multiflori extract 10%, hawthorn extract 14%, green-tea extract 8%th, sorbierite 8%, white oil 8%, polyoxyethylene lauryl alcohol ether 3%, Tween-60 0.1%, methyl hydroxybenzoate 0.1%, surplus are Pure water.
2nd, preparation method
1) pure water of 40% formula ratio and notoginseng essential oil, radix-polygoni multiflori extract, hawthorn extract, green-tea extract are taken Mixing, boils under normal pressure, and keeps fluidized state 30 minutes, and standing is cooled to 80 DEG C, and filter to get filtrate A;
2) pure water of 60% formula ratio and sorbierite, white oil, polyoxyethylene lauryl alcohol ether, Tween-60, mud pool tortoise beetle are taken Ester is mixed and heated to 80 DEG C, and liquor B is obtained by filtration;
3) filtrate A and liquor B are mixed and carries out emulsifying, 2000 revs/min of speed of agitator is kept for 10 minutes, vacuum Deaeration, up to product of the present invention after cooling.
Embodiment 2
1st, raw material proportioning:Notoginseng essential oil 20%, radix-polygoni multiflori extract 15%, hawthorn extract 15%, green-tea extract 9%th, sorbierite 8%, white oil 8%, polyoxyethylene lauryl alcohol ether 5%, Tween-60 0.2%, methyl hydroxybenzoate 0.2%, surplus are Pure water
2nd, preparation method
1) pure water of 40% formula ratio and notoginseng essential oil, radix-polygoni multiflori extract, hawthorn extract, green-tea extract are taken Mixing, boils under normal pressure, and keeps fluidized state 25 minutes, and standing is cooled to 78 DEG C, and filter to get filtrate A;
2) pure water of 60% formula ratio and sorbierite, white oil, polyoxyethylene lauryl alcohol ether, Tween-60, mud pool tortoise beetle are taken Ester is mixed and heated to 78 DEG C, and liquor B is obtained by filtration;
3) filtrate A and liquor B are mixed and carries out emulsifying, 2200 revs/min of speed of agitator is kept for 9 minutes, and vacuum takes off Bubble, up to product of the present invention after cooling.
Embodiment 3
1st, raw material proportioning:Notoginseng essential oil 22%, radix-polygoni multiflori extract 18%, hawthorn extract 16%, green-tea extract 10%th, sorbierite 10%, white oil 10%, polyoxyethylene lauryl alcohol ether 6%, Tween-60 0.3%, methyl hydroxybenzoate 0.3%, remaining It measures as pure water.
2nd, preparation method
1) pure water of 40% formula ratio and notoginseng essential oil, radix-polygoni multiflori extract, hawthorn extract, green-tea extract are taken Mixing, boils under normal pressure, and keeps fluidized state 30 minutes, and standing is cooled to 80 DEG C, and filter to get filtrate A;
2) pure water of 60% formula ratio and sorbierite, white oil, polyoxyethylene lauryl alcohol ether, Tween-60, mud pool tortoise beetle are taken Ester is mixed and heated to 80 DEG C, and liquor B is obtained by filtration;
3) filtrate A and liquor B are mixed and carries out emulsifying, 2000 revs/min of speed of agitator is kept for 10 minutes, vacuum Deaeration, up to product of the present invention after cooling.
Experimental analysis
Experiment one:Human facial skin's mass quantitatively detects
1st, the selection of subjects
Informed consent form, health, wherein 100 volunteers at age 19-40 Sui, male 16 are voluntarily signed in selection Name, women 84 are randomly divided into two groups, every group 50 (control male does not divide entirely at same group).
2nd, experimental design
After every subject is cleaned up sooner or later with unified mildy wash, A groups subject presses Radix Notoginseng provided by the invention The cream that rubs is applied to face, and B groups subject is applied to face using commercially available facial massage cream, using identical gimmick, massages 10 minutes, It is cleaned again with clear water, the test period is 30 days.
3rd, process is tested
According to moisture of skin, oil, the standardization detection method that pH is measured, skin elasticity measures, standard operation rule are established Journey is detected subject's forehead, skin of cheek using reference instrument, and each index determining of every subject is made even twice Mean value, each index determining result of every group of subject are averaged again.
4th, result of the test and analysis
Each parametric measurement result of skin quality before and after 1 A groups subject of table experiment
As can be seen from Table 1, subject is after product of the present invention is used, passage at any time, forehead and skin of cheek Oil is substantially reduced, and forehead and skin of cheek moisture are significantly raised, and are significantly improved using rear cheek skin elasticity.
Each parametric measurement result of skin quality before and after 2 B groups subject of table experiment
As can be seen from Table 2, subject is after commercially available facial massage cream is used, passage at any time, on cheek oil has The trend of liter, this product oil-control is ineffective, forehead and skin of cheek moisture variation unobvious, and uses rear cheek skin elasticity Gradually it is deteriorated.
A groups and B group data comparisons, product of the present invention can have forehead, skin of cheek preferable oil-control, moisturizing water lock effect Fruit, and make moderate progress to the elasticity of skin of cheek.
Experiment two:Removing freckle function human trial is gone in present invention desalination
1st, the selection of subjects
The apparent female patient 40 of 18-40 Sui freckle is selected, gestation or women breast-feeding their children is excluded, excludes to mistake of the present invention Quick person, exclude to merge intentionally, liver, the severe primaries Disease such as kidney and hemopoietic system, it is voluntary, experiment to participate in experimenter Phase is 30 days, and after every subject is cleaned up sooner or later with unified mildy wash, Radix Notoginseng massage cream provided by the invention is applied to Face using identical gimmick, is massaged 10 minutes, then cleaned with clear water.
2nd, process is tested:
(1) detection of freckle size:Participate in experimenter try out the present invention it is front and rear with same digital camera in specific item Front, left side and right side photo are shot under part, full face freckle is measured with " skin pigment spot image quantization analysis system " Area (cm2)。
(2) nti-freckle attacks effect evaluation:
It is effective:Freckle color change is apparent, and freckle area reduces >=70%, and does not generate new freckle (original freckle portion Position freckle number increases but area reduces, and is considered as and does not generate new freckle).
Effectively:Freckle lighter, while area reduces >=10%, and does not generate new freckle (original freckle position sparrow Spot number increases but area reduces, and is considered as and does not generate new freckle).
In vain:Freckle color and area are without significant change or exacerbation.
3rd, result of the test:
(1) freckle size measurement result
3 freckle size measurement result of table
Note:* is difference extremely significantly (P<0.01).
As can be seen from Table 3, before and after the test, the average freckle area of experimenter becomes smaller, the area to become smaller>10%, and Itself difference extremely significantly (P<0.01).
(2) freckle effect is evaluated
4 freckle effect of table is evaluated
As can be seen from Table 4, after using product of the present invention, obvious effective rate 17.5%, effective percentage reaches 70%, and inefficiency Only 12.5%, the present invention is prompted to have and preferably desalinates, go the effect of removing freckle.
Experiment three:Present invention prevention, treatment chestnut papule function human trial
1st, the selection of subjects
The apparent female patient 50 of 25-40 Sui chestnut papule is selected, is excluded to allergy sufferers of the present invention, participating in experimenter is Voluntarily, experimental period is 30 days, and after every subject is cleaned up sooner or later with unified mildy wash, Radix Notoginseng provided by the invention is pressed The cream that rubs is applied to face, using identical gimmick, massages 10 minutes, then cleaned with clear water.
2nd, process is tested:
(1) chestnut papule number counts:Participate in experimenter try out the present invention it is front and rear with same digital camera under given conditions Shooting, counts chestnut papule number.
(2) efficacy assessments:
It is effective:Chestnut papule number significantly reduces >=70%, and does not generate new chestnut papule.
Effectively:Chestnut papule number reduces >=20%, and does not generate new chestnut papule.
In vain:Chestnut papule number is constant or increases.
3rd, result of the test:
5 effective evaluation of table
As can be seen from Table 5, after using product of the present invention, obvious effective rate 22%, effective percentage reaches 66%, and inefficiency only has 12%, product of the present invention is prompted to have the effect of anti-and treatment chestnut papule.
The present invention is using the volatile oil of valuable ingredient of traditional Chinese medicine Radix Notoginseng as primary raw material, with radix-polygoni multiflori extract, hawthorn extract, green tea Extract carries out reasonable compatibility, wherein, notoginseng essential oil energy relaxed muscle, the tight feeling of releive face, neck;The fleece-flower root extracts The activity of object energy enhancement of SOD and catalase eliminates free radical, slows down aging;Hawthorn extract can promote blood circulation, and subtract Light-water swells, and cell is made to be easier to absorb nutrient, excludes waste, anti-oxidant;Green-tea extract can block lipid peroxidation process, tool There is antibacterial action, can effectively inhibit the activation of melanocyte, mitigate pigmentation;Especially, hawthorn extract is extracted with green tea Object compatibility has chestnut papule preferable prevention and treatment effect, realizes resisting age of skin, desalinate freckle, eliminate facial edema, Promote the absorption of nutriment, make skin is ruddy to compact.Preparation method of the present invention makes each component uniform by controlling technological parameter The effect of mixing, the property for making product of the present invention is more reliable, active ingredient, is preferably played.
Finally illustrate, preferred embodiment above is merely illustrative of the technical solution of the present invention and unrestricted, although logical It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be Various changes are made to it in form and in details, without departing from claims of the present invention limited range.

Claims (3)

1. a kind of Radix Notoginseng massage cream, which is characterized in that the Radix Notoginseng massage cream is made of the raw material of following weight ratio:Radix Notoginseng is waved Hair oil 15~22%, radix-polygoni multiflori extract 10~18%, hawthorn extract 14~16%, green-tea extract 8~10%, sorbierite 8~10%, the .3% of white oil 8~10%, polyoxyethylene lauryl alcohol ether 3~6%, 0 .1 of Tween-60~0, methyl hydroxybenzoate 0 .1~0 .3%, surplus are pure water.
2. a kind of Radix Notoginseng massage cream according to claim 1, which is characterized in that Radix Notoginseng massage cream by following weight ratio original Material composition:Notoginseng essential oil 20%, radix-polygoni multiflori extract 15%, hawthorn extract 15%, green-tea extract 9%, sorbierite 8%th, white oil 8%, polyoxyethylene lauryl alcohol ether 5%, 0 .2% of Tween-60,0 .2% of methyl hydroxybenzoate, surplus are pure water.
3. a kind of preparation method of Radix Notoginseng massage cream according to claim 1 or 2, it is characterised in that:The specific steps are:
1)The pure water of 40% formula ratio is taken to be mixed with the radix-polygoni multiflori extract of formula ratio, hawthorn extract, green-tea extract It is even, sorbierite, the Tween-60 of formula ratio are added, is boiled under normal pressure, and keeps fluidized state 20-30 minutes, stands cooling To 70-80 DEG C, filter to get filtrate A;
2)The pure water of 60% formula ratio is taken to be uniformly mixed and heat with the notoginseng essential oil of formula ratio, white oil, methyl hydroxybenzoate To 70-80 DEG C, liquor B is obtained by filtration;
3)Filtrate A and liquor B are mixed, and the polyoxyethylene lauryl alcohol ether for adding in formula ratio carries out emulsifying, speed of agitator It 2000-2400 revs/min, is kept for 8-10 minutes, vacuum defoamation;
4)Step 3)Gains are cooled to 40 DEG C of inspections, pack to get product.
CN201511029851.XA 2015-12-30 2015-12-30 A kind of Radix Notoginseng massage cream and preparation method thereof Active CN105434279B (en)

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CN106619225A (en) * 2017-01-03 2017-05-10 成都景睿生物科技有限公司 Skin-whitening essential oil
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