WO2011070613A1 - Composition pour lentilles de contact et procédé pour supprimer une interaction négative l'utilisant - Google Patents

Composition pour lentilles de contact et procédé pour supprimer une interaction négative l'utilisant Download PDF

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Publication number
WO2011070613A1
WO2011070613A1 PCT/JP2009/006704 JP2009006704W WO2011070613A1 WO 2011070613 A1 WO2011070613 A1 WO 2011070613A1 JP 2009006704 W JP2009006704 W JP 2009006704W WO 2011070613 A1 WO2011070613 A1 WO 2011070613A1
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Prior art keywords
contact lens
solution
liquid
composition
contact
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PCT/JP2009/006704
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English (en)
Japanese (ja)
Inventor
塚本桂史
谷川定康
小川晋
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株式会社メニコン
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Priority to PCT/JP2009/006704 priority Critical patent/WO2011070613A1/fr
Publication of WO2011070613A1 publication Critical patent/WO2011070613A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/14—Boron; Compounds thereof

Definitions

  • the present invention relates to a composition for contact lenses and a method for suppressing negative interaction using the composition.
  • the contact lens is in contact with various liquids from the time it is manufactured until it is used by the user and during the period of use by the user. Specifically, for example, from manufacturing to use by the user, it is stored in a package soaked in the packaging solution, and when used by the user, it comes into contact with contact lens mounting solution or eye drops. It becomes. Furthermore, when the user cleans the worn contact lens, the user comes into contact with the contact lens multipurpose liquid, sterilizing liquid, cleaning liquid, rinsing liquid, and the like, and then stored in a liquid such as a storage liquid. As described above, various liquids come into contact with the contact lens on a daily basis, and in the process, various liquids are often mixed and contacted with the contact lens.
  • a contact lens composition for reducing the feeling of foreign matter and dryness when wearing a contact lens As a contact lens composition for reducing the feeling of foreign matter and dryness when wearing a contact lens, cited reference 1 (Japanese Patent Application Laid-Open No. 2004-77953) and cited reference 2 (Japanese Patent Application Laid-Open No. 2006-2007). No. 39529), cited reference 3 (Japanese Patent Laid-Open No. 2003-107416), and the like are considered. Moreover, the composition for contact lenses described in the cited reference 4 (patent 4267673) etc. are also devised as what stabilized viscosity more than these compositions for contact lenses.
  • a contact lens composition such as a mounting liquid used in contact with a contact lens is mixed with various liquids that come into contact with other contact lenses in actual use.
  • various liquids already in contact with the contact lens for example, multipurpose liquids for contact lenses, packaging solutions, protein washing / removal
  • the agent, the preserving liquid, the cleaning liquid, the rinsing liquid, and the mounting liquid come into contact with each other and are mixed with each other.
  • the wearer's tear fluid, eye drops, eye wash, and the like are brought into contact and mixed.
  • two or more eye drops may be used in combination, or a protein washing / removing agent may be added to the preservation solution.
  • the present invention has been made in the background as described above, and the problem to be solved is that the first liquid that comes into contact with the contact lens and the composition for contact lens are mixed and contacted.
  • An object of the present invention is to provide a novel composition for contact lenses that can suppress the occurrence of negative interactions caused by the above.
  • an object of the present invention is to provide a novel method for suppressing such negative interaction.
  • the first aspect of the present invention relating to a contact lens composition is a multipurpose solution for contact lenses, a bactericidal solution, a cleaning solution, a protein cleaning / removing agent, a preserving solution, a rinsing solution, an ophthalmic solution, an eyewash solution, a mounting solution, a packaging.
  • a contact lens composition that is mixedly contacted with a first liquid that comes into contact with a contact lens selected from at least one of a solution, a hydration treatment liquid, and a tear fluid.
  • the composition for contact lenses according to the present invention for example, even if the contact lens composition such as a mounting liquid or eye drops is mixed and contacted with the first liquid such as the multipurpose liquid for contact lenses, Contact lenses associated with such negative interactions can be suppressed by suppressing the occurrence of negative interactions, that is, the formation of precipitates, the formation of precipitates, gelation, reduction in viscosity, reduction in water wettability of contact lens surfaces, etc. It is possible to prevent the appearance of foreign matter and dryness during wearing, and it is possible to prevent the wearing feeling from being lowered. In addition, by suppressing the occurrence of such negative interactions, the physical properties of the composition for contact lenses and the solution characteristics of the first liquid are prevented from being deteriorated, and the respective desired effects are exhibited well. Can do. Moreover, according to the present invention, in addition to the above-described phenomenon such as the formation of precipitates, it is possible to suppress negative interactions such as a decrease in bactericidal efficacy and a decrease in drug efficacy.
  • a second aspect of the present invention relating to a contact lens composition is characterized in that the contact lens composition according to the first aspect includes a low-molecular polyol compound.
  • the water wettability of the contact lens surface can be improved by blending the low molecular polyol compound according to this embodiment. Thereby, a dry feeling at the time of wearing a contact lens can be prevented, and the wearing feeling can be further improved.
  • the contact lens composition according to the second aspect wherein the low-molecular polyol compound is glucose, sucrose, lactose, maltose, trehalose, erythritol, xylitol, multi It contains at least one selected from Toll, Mannitol, and Sorbitol.
  • the low-molecular polyol compound is glucose, sucrose, lactose, maltose, trehalose, erythritol, xylitol, multi It contains at least one selected from Toll, Mannitol, and Sorbitol.
  • the negative interaction caused by the mixed contact between the contact lens composition and the first liquid can be particularly suitably suppressed. That is, by adopting the above-mentioned sugar and / or sugar alcohol as the low molecular weight polyol compound, negative effects caused between the components of the composition for contact lenses and the components such as boric acid contained in the first liquid. Can be particularly preferably inhibited, and as a result, it is possible to effectively prevent a decrease in wearing feeling due to the occurrence of precipitation or the like.
  • a fourth aspect of the present invention relating to a contact lens composition is characterized in that the contact lens composition according to any one of the first to third aspects includes a polymer polyol compound.
  • the viscosity of the contact lens composition can be effectively improved, and the wearing feeling of the contact lens can be further improved. That is, in the conventional contact lens composition, the polymer polyol compound has been blended for the purpose of increasing the viscosity and improving the wearing feeling, but the polymer polyol compound is used as the first liquid. When mixed and contacted, negative interactions such as the formation of precipitates and a decrease in viscosity occur between the components of the first liquid and the polymer polyol compound, and the feeling of wearing may decrease on the contrary. .
  • the negative interaction with the first liquid can be suppressed, so that a decrease in viscosity and the like can be prevented, and the wearing feeling of the contact lens can be prevented. Can be improved effectively.
  • the wettability of the contact lens surface is particularly preferably improved, so that the wearing feeling of the contact lens can be further improved.
  • a fifth aspect of the present invention relating to a contact lens composition is the contact lens composition according to the fourth aspect, wherein the polymer polyol compound has a kinematic viscosity of 30 mm 2 / s or less in a 4% by weight aqueous solution. It is characterized by being a certain polyvinyl alcohol.
  • the first aspect of the present invention relating to a method for suppressing negative interactions is a multipurpose solution for contact lenses, a bactericidal solution, a washing solution, a protein washing / removing agent, a preserving solution, a rinsing solution, an ophthalmic solution, an eyewash solution, and an attachment
  • a negative liquid generated by mixing and contacting a contact lens composition with a first liquid that contacts a contact lens selected from at least one of a liquid, a packaging solution, a hydration solution, and a tear fluid
  • a method for suppressing interaction wherein the contact lens composition according to any one of claims 1 to 5 is used as the contact lens composition, and mixed contact with the first liquid is performed.
  • the negative interaction is characterized by suppressing at least one of precipitate formation, precipitate formation, gelation, viscosity reduction, and contact lens surface water wettability reduction.
  • the contact lens composition according to any one of the first to fifth aspects of the present invention related to the contact lens composition described above a first contact with the contact lens is achieved. Negative interaction due to mixed contact between the liquid and the contact lens composition can be suppressed, and deterioration of wearing feeling, deterioration of liquidity, and the like can be prevented.
  • the second aspect of the present invention relating to a method for suppressing negative interaction is a multipurpose solution for contact lenses, a bactericidal solution, a washing solution, a protein washing / removing agent, a preservation solution, a rinsing solution, an ophthalmic solution, an eyewash solution, and a wearing
  • a negative liquid generated by mixing and contacting a contact lens composition with a first liquid that contacts a contact lens selected from at least one of a liquid, a packaging solution, a hydration solution, and a tear fluid
  • the contact lens composition is at least one selected from low molecular polyol compounds consisting of glucose, sucrose, lactose, maltose, trehalose, erythritol, xylitol, maltitol, mannitol, sorbitol.
  • the negative contact due to the mixed contact with the first liquid.
  • composition for contact lenses containing the low molecular polyol compound by using the composition for contact lenses containing the low molecular polyol compound, negative interaction due to the mixed contact between the first liquid contacting the contact lenses and the composition for contact lenses is suppressed. be able to.
  • the present invention even if the first liquid that contacts the contact lens and the contact lens composition are mixed and contacted, the formation of precipitates, the formation of precipitates, gelation, the decrease in viscosity, the contact lens surface Negative interactions such as reduced water wettability are suppressed. Thereby, it is possible to prevent a decrease in wearing feeling of the contact lens due to the negative interaction.
  • the contact lens composition as one embodiment of the present invention relating to a contact lens composition is a multipurpose solution for contact lenses, a bactericidal solution, a cleaning solution, a protein cleaning / removing agent, a storage solution, a rinsing solution, an ophthalmic solution, an eyewash solution, It is used after being mixed and contacted with a first liquid that comes into contact with a contact lens selected from at least one of a mounting liquid, a packaging solution, a hydration treatment liquid, and a tear liquid. And the composition for contact lenses according to the present embodiment also reduces the formation of precipitates, the formation of precipitates, gelation, the decrease in viscosity, and the water wettability of the contact lens surface by mixing contact with the first liquid.
  • the first liquid referred to in the present embodiment the first liquid
  • the negative interaction that occurs in mixed contact with a conventional contact lens composition will be described.
  • contact lens mounting solutions have been considered as contact lens mounting solutions, eye drops, and the like.
  • a contact lens composition such as a mounting solution
  • the mounting liquid is often used by being dropped onto a contact lens immediately before wearing, but the storage liquid or cleaning liquid adhered to the contact lens immediately before wearing when it is taken out from a storage container or the like. Or a mixture thereof is in contact.
  • the mounting liquid is dropped onto such a contact lens, the mounting liquid comes into contact with the storage liquid, the cleaning liquid, and the like on the lens surface and is mixed.
  • the components included in the contact lens composition and the components included in the first liquid May cause undesired phenomena such as formation of precipitates, formation of precipitates, gelation, decrease in viscosity, and reduction in water wettability of contact lens surfaces.
  • these unfavorable phenomena such as the formation of precipitates, the formation of precipitates, gelation, reduction in viscosity, and reduction in water wettability of the contact lens surface are collectively referred to as negative interactions. If such a negative interaction occurs, there is a risk that an unpleasant phenomenon will be caused to the user, such as a feeling of foreign matter or dryness when the contact lens is worn, or a blurred field of view.
  • the contact lens composition as a mounting liquid has an effect such as improvement of water wettability that is aimed at, or the first liquid has a buffering action. There is a possibility that the various effects of the decrease.
  • composition for contact lenses according to the present embodiment can suitably suppress the negative interaction caused by the mixed contact between the first liquid and the composition for contact lenses.
  • this embodiment is explained in full detail.
  • a contact lens in this embodiment a hard contact lens, an oxygen permeable hard contact lens, a soft contact lens, a silicone hydrogel soft contact lens, a hybrid contact lens (a combination of an oxygen permeable hard contact lens and a soft contact lens)
  • Well-known contact lenses such as contact lenses
  • orthokeratology lenses fashionable color contact lenses, and the like are used without particular limitation.
  • the usage form of the contact lens is not particularly limited. That is, it may be a disposable contact lens that is used only for a short period such as one day or one week to several months, or a normal contact lens that is used for a longer period.
  • the contact lens composition When the contact lens composition is mixed and contacted with the first liquid described later, the contact lens composition has at least one negative effect of precipitation formation, precipitate formation, gelation, viscosity reduction, and contact lens surface water wettability reduction. It has a composition that can suppress the interaction.
  • the specific composition of the contact lens composition is not particularly limited as long as negative interaction can be suppressed, but preferably, for example, a low molecular polyol compound is blended in the contact lens composition.
  • a low molecular polyol compound is blended in the contact lens composition.
  • the negative interaction with the first liquid can be particularly suitably suppressed.
  • such a low molecular polyol compound suppresses the negative interaction by mixing boric acid in at least one of the contact lens composition and the first liquid and polyvinyl alcohol in the other. In particular, it is particularly effective.
  • the negative interaction suppression effect by the low-molecular polyol compound works effectively even for negative interactions caused by causes other than mixing of boric acid and polyvinyl alcohol.
  • the wettability of the contact lens is also improved, so that the wearing feeling of the contact lens is also improved.
  • the low molecular polyol compound in particular, a compound selected from at least one of glucose, sucrose, lactose, maltose, trehalose, erythritol, xylitol, maltitol, mannitol, and sorbitol is desirably employed.
  • a compound selected from at least one of glucose, sucrose, lactose, maltose, trehalose, erythritol, xylitol, maltitol, mannitol, and sorbitol is desirably employed.
  • negative interactions can be particularly effectively suppressed while preventing eye irritation and effects on physical properties of contact lenses.
  • a low molecular polyol compound only 1 type of the above-mentioned substance may be employ
  • glucose, trehalose, erythritol, mannitol, and sorbitol are preferably employed, more preferably erythritol and mannitol are employed, and most preferably mannitol is employed.
  • Such a low-molecular polyol compound is desirably blended at a concentration of 0.1 to 10% by weight, and more desirably at a concentration of 0.5 to 5% by weight. If the concentration is within such a range, the negative interaction can be suppressed particularly effectively. That is, even if the concentration is increased to more than 10% by weight, the negative interaction suppressing effect becomes flat and waste may occur. Furthermore, when the osmotic pressure increases, there may be a case where the contact lens specification changes or eye irritation occurs. On the other hand, when the concentration is less than 0.1% by weight, there is a possibility that the effect of suppressing the negative interaction cannot be sufficiently obtained.
  • the concentration ratio of the high molecular polyol compound to the low molecular polyol compound is 1: 1 to 1:10 ( High molecular polyol compound: low molecular polyol compound) is preferable.
  • High molecular polyol compound: low molecular polyol compound By blending the low-molecular polyol compound at such a concentration ratio, a more desirable negative interaction suppression effect can be obtained.
  • the causes of various negative interactions caused by the mixed contact between the conventional contact lens composition and the first liquid, and the mechanism by which such negative interactions are suppressed by the blending of the low molecular polyol compound are as follows. Although not yet clear, the following hypothesis is considered as one guess. For example, in the mixed contact of the contact lens composition containing polyvinyl alcohol and the first liquid containing boric acid, boric acid contained in the first liquid and the like, polyvinyl alcohol contained in the contact lens composition, etc. One of the causes is considered to form a network due to hydrogen bonding or the like during mixing.
  • a low molecular polyol compound such as mannitol is blended in the contact lens composition, so that the hydroxyl group (—OH) of the low molecular polyol compound is involved in the formation of a network by hydrogen bonding. Therefore, it is speculated that the formation can be inhibited, and as a result, negative interactions such as precipitation, cloudiness, and gelation can be suppressed.
  • the low-molecular polyol compound such as mannitol described above is blended particularly when boric acid is blended in one of the contact lens composition and the first liquid and polyvinyl alcohol is blended in the other. In addition, it is possible to particularly effectively prevent the negative interaction due to the mixture of boric acid and polyvinyl alcohol.
  • the present embodiment is particularly preferably applied to a contact lens composition containing a polymer polyol compound such as polyvinyl alcohol. That is, the composition for contact lenses is often blended with a polymer polyol compound such as polyvinyl alcohol as a thickener for improving the viscosity of the composition for contact lenses.
  • a polymer polyol compound such as polyvinyl alcohol as a thickener for improving the viscosity of the composition for contact lenses.
  • a polymer polyol compound when such a polymer polyol compound is mixed with a first liquid containing boric acid or the like, negative interactions such as precipitation, white turbidity, and gelation occur. Wearing feeling may be greatly reduced.
  • the first liquid contains boric acid
  • a negative interaction such as formation of a precipitate occurs.
  • the contact lens composition containing a polymer polyol compound such as polyvinyl alcohol and the first liquid containing boric acid are mixed and contacted, the contact lens composition has mannitol or the like. Negative interaction can be suppressed, for example, by blending the low molecular polyol compound. As a result, the thickening action of the polymer polyol compound can be sufficiently exerted.
  • the wettability of the contact lens is greatly enhanced by the synergistic effect. That is, the low-molecular polyol compound has an effect of improving the wettability to some extent in addition to the action of suppressing the negative interaction, but the wettability is further increased by blending it with the high-molecular polyol compound. It is. Therefore, by combining a high-molecular polyol compound and a low-molecular polyol compound in combination, the wettability of the contact lens is greatly improved and the formation of gelation and precipitation due to the interaction with the first liquid is suppressed. This can advantageously improve the wearing feeling of the contact lens. Therefore, it is desirable that the composition for contact lenses according to the present embodiment contains a polymer polyol compound.
  • the specific composition of the polymer polyol compound is not particularly limited, and specifically, for example, polyalkylene glycols such as polyethylene glycol and polypropylene glycol, polyoxyethylene polyoxypropylene block copolymer, polyoxyethylene poly Polyoxyalkylenes such as oxypropylene ethylenediamine, glycerin derivatives such as polyglycerin and polyglycerin esters, vinyl polymers such as polyvinyl alcohol, polysaccharides such as galactomannan, glucomannan, and pullulan can be employed.
  • polyvinyl alcohol is most preferably used.
  • kinematic viscosity in this embodiment is a numerical value prescribed
  • the concentration of the polymer polyol compound is 0.01 to 5% by weight, preferably 0.1 to 3% by weight, and more preferably 0.2 to 2% by weight.
  • concentration is within such a range, the negative interaction can be particularly effectively suppressed. That is, when the concentration is more than 5% by weight, the negative interaction may not be sufficiently suppressed.
  • concentration is less than 0.01% by weight, the effect of improving the wettability by the combination with the thickening action or the low molecular polyol compound may not be sufficiently exhibited.
  • the contact lens composition according to the present embodiment for example, a contact lens multipurpose solution, a bactericidal solution, a cleaning solution, a protein cleaning / removing agent, a preserving solution, a rinsing solution, and an ophthalmic solution, as long as the inhibitory effect of negative interaction is not limited.
  • a solution for contact lenses such as eyewash, mounting solution, packaging solution, hydration solution, etc.
  • it can be used without any particular limitation.
  • it may have a plurality of forms as a combination of the above forms such as contact lens mounting liquid and eye drops or eye drops and eye wash.
  • the present embodiment is particularly suitably applied as a contact lens mounting solution, an eye drop solution, a packaging solution, and a contact lens multipurpose solution.
  • the specific composition of the substance to be blended in the contact lens composition is not particularly limited as long as the negative interaction suppressing effect is not limited.
  • any composition known in the art as a contact lens multipurpose solution, bactericidal solution, cleaning solution, protein cleaning / removing agent, preserving solution, rinsing solution, eye drops, eyewash solution, mounting solution, packaging solution, hydration solution, etc. can also be employed.
  • additives can be appropriately added to the contact lens composition in addition to the above-described high-molecular polyol compound and low-molecular polyol compound. That is, known buffers, pH adjusters, preservatives / bactericides, surfactants, thickeners, tonicity agents, chelating agents, wetting agents, stabilizers, perfumes or cooling agents that can be included in each of the above liquids
  • An agent, a drug, an antibacterial agent, vitamins, and the like can be blended in one or a combination of two or more.
  • the above-mentioned low molecular polyol compound can also act as, for example, an isotonic agent in addition to the above-described action of suppressing the negative interaction. Therefore, the contact lens composition may be composed of only a low molecular polyol compound or a high molecular polyol compound, or may be added in combination with other additives.
  • the buffer examples include boric acid, borax and borate buffer, carbonate buffer, citric acid and citrate buffer, carboxylic acids such as acetic acid, acids such as oxycarboxylic acid and salts thereof, aminoethyl Amino acids such as sulfonic acid, glycine, arginine, glutamic acid, ⁇ - aminocaproic acid, 2-amino-2-methyl-1,3-propane (AMP) buffer, tris (hydroxymethyl) aminomethane (Tris) buffer, Bis (2-hydroxyethyl) iminotris (hydroxymethyl) methane (Bis-Tris), phosphoric acid and phosphate buffer, Good-Buffer, and the like.
  • carboxylic acids such as acetic acid
  • acids such as oxycarboxylic acid and salts thereof
  • aminoethyl Amino acids such as sulfonic acid, glycine, arginine, glutamic acid, ⁇ - aminocaproic acid, 2-amino-2
  • pH adjusting agent examples include hydrochloric acid, citric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogen carbonate, sodium hydrogen phosphate, sodium dihydrogen phosphate, phosphates, sulfuric acid and the like.
  • preservatives and bactericides include sorbic acid, potassium sorbate, benzoic acid or salts thereof, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, chlorobutanol, benzalkonium chloride, Polyhexamethylene biguanide (PHMB; polyhexanide hydrochloride), alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride (CPC), chlorhexidine, alexidine, chlorpheniramine or its salts, allantoin, chlorine dioxide, sodium perborate, polydronium chloride, etc. And the like.
  • PHMB polyhexamethylene biguanide
  • CPC cetylpyridinium chloride
  • any of the conventionally known anionic surfactants, nonionic surfactants, and amphoteric surfactants can be appropriately employed.
  • thickener examples include synthetic organic polymer compounds such as polyvinylpyrrolidone, polyacrylamide, poly (meth) acrylic acid, and Copolymer 845 (copolymer of polyvinylpyrrolidone and dimethylaminoethyl methacrylate), methylcellulose, ethylcellulose, and hydroxymethylcellulose.
  • synthetic organic polymer compounds such as polyvinylpyrrolidone, polyacrylamide, poly (meth) acrylic acid, and Copolymer 845 (copolymer of polyvinylpyrrolidone and dimethylaminoethyl methacrylate), methylcellulose, ethylcellulose, and hydroxymethylcellulose.
  • Cellulose derivatives such as hydroxypropylmethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, carboxyethylcellulose, starch derivatives, polysaccharides such as alginic acid, chitosan and their salts, various gums such as heteropolysaccharides, hyaluronic acid (salts) ), Mucopolysaccharides such as chondroitin sulfate (salt), and the like.
  • tonicity agents examples include inorganic salts such as sodium chloride, potassium chloride, sodium bisulfite, sodium sulfite, magnesium chloride, potassium acetate, sodium acetate, sodium thiosulfate, and magnesium sulfate, and polyhydric alcohols such as propylene glycol and glycerin. Alternatively, ethers or esters thereof may be mentioned.
  • chelating agent examples include ethylenediaminetetraacetic acid (EDTA) and salts thereof, ethylenediaminetetraacetic acid ⁇ disodium (EDTA ⁇ 2Na), ethylenediaminetetraacetic acid ⁇ 3sodium (EDTA ⁇ 3Na), ethylenediaminetetraacetic acid ⁇ 4sodium (EDTA ⁇ 4Na). ), Phytic acid, citric acid and the like.
  • EDTA ethylenediaminetetraacetic acid
  • EDTA ethylenediaminetetraacetic acid
  • salts thereof examples include ethylenediaminetetraacetic acid ⁇ disodium (EDTA ⁇ 2Na), ethylenediaminetetraacetic acid ⁇ 3sodium (EDTA ⁇ 3Na), ethylenediaminetetraacetic acid ⁇ 4sodium (EDTA ⁇ 4Na).
  • Phytic acid citric acid and the like.
  • wetting agent examples include cellulose derivatives such as cationized cellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose and methylcellulose, lower or higher alcohols such as ethanol, isopropanol, oleyl alcohol and lauryl alcohol, almond oil, lanolin, olive oil, oleic acid and And / or its salts, oils and fats such as liquid paraffin, triglyceride, squalane, petrolatum, silicone oil, sesame oil, perilla oil, soybean oil, camellia oil, jojoba oil, corn oil, castor oil and the like.
  • cellulose derivatives such as cationized cellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose and methylcellulose
  • lower or higher alcohols such as ethanol, isopropanol, oleyl alcohol and lauryl alcohol
  • almond oil lanolin
  • olive oil oleic acid and And / or its salts
  • oils and fats such as liquid paraffin, trig
  • Stabilizers include ascorbic acid, sodium edetate, cyclodextrin, condensed phosphoric acid, sulfite, citric acid, dibutylhydroxytoluene, trometamol, sodium formaldehyde sulfoxylate (Longalite), tocopherol, sodium pyrosulfite, monoethanolamine, Examples thereof include aluminum monostearate.
  • fragrance or refreshing agent examples include anethole, eugenol, camphor, chlorobutanol, geraniol, cineol, borneol, menthol, limonene, ryuunou, fennel oil, cool mint oil, cinnamon oil, spearmint oil, peppermint water, peppermint oil, peppermint Oil, bergamot oil, eucalyptus oil, rose oil and the like.
  • Examples of the drug include cromoglycic acid, tranilast, chlorpheniramine maleate, diphenhydramine hydrochloride, amlexanox, ibudilast, pemirolast potassium, emedastine fumarate, ketotifen fumarate, olopatadine hydrochloride, ebastine, acitazanolast, levocabastine hydrochloride, etc.
  • Anti-allergic agents glycyrrhizic acid and its salts, ⁇ -aminocaproic acid, allantoin, sodium azulenesulfonate, berberine chloride, berberine sulfate, zinc sulfate, zinc lactate, lysozyme, fluorometholone and other anti-inflammatory agents
  • Blood vessels such as epinephrine, epinephrine hydrochloride, epinephrine hydrochloride, ephedrine hydrochloride, naphazoline hydrochloride, naphazoline nitrate, phenylephrine hydrochloride, tetrahydrozoline hydrochloride
  • Agents focusing function improving agent such as neostigmine methylsulfate, betaxolol, timolol, dipivefrin, carteolol, Ratanopurasuto, Tafurupurasuto, Torabo
  • Antibacterial agents include, for example, sulfamethoxazole, sulfamethoxazole sodium, sulfisoxazole, sulfisomidine sodium and other sulfa drugs, ofloxacin, norfloxacin, levofloxacin, gatifloxacin, moxifloxacin, tosufloxacin New quinolone antibacterial agents such as romefloxacin and ciprofloxacin, aminoglycoside antibacterial agents such as tobramycin, gentamicin, micronomycin, dibekacin and sisomycin, tetracycline antibacterial agents such as tetracycline and minocycline, and macrolide antibacterial agents such as erythromycin And chloramphenicol antibacterial agents such as chloramphenicol, and cephem antibacterial agents such as cefmenoxime.
  • sulfamethoxazole sulfamethoxazole sodium,
  • vitamins examples include vitamin A (including retinol palmitate, ⁇ -carotene, etc.), vitamin B2 (flavin adenine nucleotide, etc.), vitamin B6 (pyridoxine hydrochloride, etc.), vitamin B12 (cyanocobalamin, etc.), vitamin C ( Ascorbic acid and the like), vitamin Es (acetic acid-d- ⁇ -tocopherol and the like), panthenol and the like.
  • vitamin A including retinol palmitate, ⁇ -carotene, etc.
  • vitamin B2 flavin adenine nucleotide, etc.
  • vitamin B6 pyridoxine hydrochloride, etc.
  • vitamin B12 cyanocobalamin, etc.
  • vitamin C Ascorbic acid and the like
  • vitamin Es acetic acid-d- ⁇ -tocopherol and the like
  • panthenol and the like examples include vitamin A (including retinol palmitate, ⁇ -carotene, etc.),
  • the first liquid is a liquid used in contact with a contact lens, and is a multipurpose liquid for contact lenses, a bactericidal liquid, a cleaning liquid, a protein cleaning / removing agent, a preserving liquid, a rinsing liquid, an eye drop, an eye wash, It is a liquid selected from at least one of a mounting liquid, a packaging solution, a hydration liquid, and a tear liquid.
  • Such first liquid is the above-mentioned contact lens multipurpose liquid, bactericidal liquid, cleaning liquid, protein cleaning / removing agent, preserving liquid, rinsing liquid, eye drops, eyewash liquid, mounting liquid, packaging solution, hydration liquid
  • it may be configured to include only one kind of tears, or may be configured to include two or more kinds.
  • a known cleaning liquid that exhibits only a cleaning action may be used, or a cleaning storage liquid that has both a cleaning action and a storage action may be used.
  • a liquid obtained by mixing a known cleaning liquid and a storage liquid may be used.
  • it may be an ophthalmic solution remaining in the conjunctival sac or a liquid agent obtained by mixing a multipurpose agent for contact lenses and tear fluid in the anterior ocular segment.
  • the specific composition of the first liquid is not particularly limited as long as it does not limit the effect of suppressing the negative interaction of the contact lens composition. That is, the composition of known multipurpose liquids for contact lenses, bactericidal liquids, cleaning liquids, protein cleaning / removing agents, preservative liquids, rinsing liquids, eye drops, eyewash liquids, mounting liquids, packaging solutions, hydrating liquids, tears liquids, As long as the inhibitory effect of the negative interaction of the composition for contact lenses is not limited, it can be arbitrarily adopted.
  • the first liquid is a known buffer, pH adjuster, preservative / bactericidal agent, surfactant, thickener, isotonic agent, which can be included in each of the above liquids,
  • a chelating agent, a wetting agent, a stabilizer, a fragrance or a refreshing agent, a drug, an antibacterial agent, vitamins, and the like may be used alone or in combination.
  • any of the additives that can be employed in the contact lens composition exemplified above can be employed without any particular limitation. To do.
  • the composition for contact lenses according to this embodiment is suitably used especially for the first liquid composed of boric acid as a buffering agent and an antiseptic / bactericidal agent. That is, when the first liquid containing boric acid is mixed with a contact lens composition containing a polymer polyol compound such as polyvinyl alcohol, negative interactions such as formation of precipitation and gelation are caused. It is likely to occur. However, when the composition for contact lenses according to this embodiment is used, even if the first liquid contains boric acid and the composition for contact lenses contains polyvinyl alcohol, the composition for contact lenses is used. By including a low molecular polyol compound or the like, generation of negative interaction can be suppressed. As a result, it is possible to prevent irritation to the eyes of the user due to precipitates and the like, and it is also possible to prevent the boric acid buffering action, antiseptic action and bactericidal action contained in the first liquid from being inhibited.
  • a polymer polyol compound such as polyvinyl alcohol
  • the negative interaction referred to in the present embodiment is not limited to that caused by the interaction between boric acid and polyvinyl alcohol. That is, the negative interaction can occur as a result of the mixed contact between the first liquid and the contact lens composition. Precipitate formation, precipitate formation, gelation, viscosity reduction, contact lens surface water wetting It is sufficient that the action includes at least one of the property reductions, and it is not limited to a specific phenomenon due to mixing of specific substances.
  • the first liquid only needs to be a solution that comes into contact with the contact lens at any stage.
  • the first liquid and the contact lens composition are mixed, the first liquid is contacted.
  • the lens may be in direct contact or may not be in contact. That is, the first liquid may contact the contact lens before or after the first liquid and the contact lens composition are mixed and contacted.
  • the specific aspect in which the first liquid and the contact lens composition are mixed and contacted is not particularly limited. For example, in a state where the first liquid is stored in a storage container or the like together with the contact lens, the contact liquid composition is added thereto, so that the first liquid and the contact lens composition are mixed and brought into contact with each other.
  • the contact lens composition may be mixed with the first liquid before the contact lens is immersed in the first liquid or when the contact lens is removed from the first liquid. May be.
  • the first liquid and the contact lens composition may be in contact with each other in the vicinity of the user's cornea while the contact lens is attached to the user's eye.
  • composition for contact lenses according to the present embodiment can be generated as a result of mixing the first liquid and the composition for contact lenses, formation of precipitates, formation of precipitates, gelation, decrease in viscosity, contact lens surface As long as it can suppress at least one action of reducing the wettability of water, only one negative interaction among these phenomena may be suppressed, or two or more It may be one that can suppress any negative interaction.
  • the first embodiment of the present invention relating to a method for suppressing negative interaction is suitably implemented by using the contact lens composition according to one embodiment of the present invention relating to the above-described contact lens composition.
  • the First at least one of contact lens multipurpose liquid, bactericidal liquid, cleaning liquid, protein cleaning / removing agent, preservative liquid, rinsing liquid, eye drops, eyewash liquid, mounting liquid, packaging solution, hydration liquid, and tear liquid
  • composition for contact lenses according to one Embodiment of this invention regarding the composition for contact lenses mentioned above is mixed-contacted with such a 1st liquid.
  • a second embodiment relating to a method for suppressing negative interaction in the first embodiment relating to the method for suppressing negative interaction described above, in particular, glucose, sucrose, lactose, maltose, trehalose, erythritol, Adopting a composition for contact lenses containing at least one selected from low molecular polyol compounds consisting of xylitol, maltitol, mannitol, sorbitol, to suitably suppress negative interaction with the first liquid Can do.
  • Bioclen Zero (manufactured by Offtex Co., Ltd.), which is a commercially available multipurpose liquid for contact lenses, was employed.
  • this bioclen zero contains 0.001 mg of polyhexanide hydrochloride (bactericidal agent) preparation in 1 ml.
  • Table 1 the composition of the contact lens composition used in this experiment is as shown in Table 1 below.
  • Examples 1 to 10 contain any one of mannitol, sorbitol, glucose, trehalose, and erythritol as a low molecular polyol compound.
  • Comparative Examples 1 and 2 do not contain these low molecular polyol compounds.
  • the contact lens compositions of Examples 1 to 10 and Comparative Examples 1 and 2 and the first liquid were mixed at a volume ratio of 1: 1. After mixing, x indicates that precipitation or precipitation occurred, no precipitation or precipitation occurs, but ⁇ indicates that the entire solution is cloudy, and ⁇ indicates that neither precipitation nor precipitation or clouding was observed. It was evaluated. The results are also shown in Table 1 below.
  • Two types of polyvinyl alcohol are used. The negative interaction can be satisfactorily suppressed even when any of the two types of polyvinyl alcohols having a kinematic viscosity of about 30 mm 2 / s or less when used as a 4% by weight aqueous solution is used.
  • kinematic viscosity of each polyvinyl alcohol is a manufacturer's standard value, and is measured in accordance with the viscosity measurement method of polyvinyl alcohol (partial saponification) defined by the pharmaceutical additive standard. That is, it is a numerical value measured at 20 ° C. using a Ubbelohde viscometer with a 4 wt% aqueous solution.
  • boric acid is blended in bioclen zero, which is a commercially available multipurpose liquid for contact lenses, and negative interactions such as precipitation and precipitation seen in Comparative Examples 1 and 2, It is presumed that the mixed contact between boric acid and polyvinyl alcohol is the main factor.
  • bioclen zero which is a commercially available multipurpose liquid for contact lenses, and negative interactions such as precipitation and precipitation seen in Comparative Examples 1 and 2, It is presumed that the mixed contact between boric acid and polyvinyl alcohol is the main factor.
  • examples 1 to 10 even when the first liquid containing boric acid and the composition for contact lenses containing polyvinyl alcohol were mixed with a low molecular polyol compound such as mannitol, negative mutual It turns out that generation
  • the first liquid used is as shown in Table 2 below. That is, as an example of a contact lens packaging solution, a packaging solution enclosed in a package of One Day Accuview (manufactured by Johnson & Johnson Co., Ltd.), a commercially available daily disposable soft contact lens, was employed. In addition, sodium chloride and a buffer agent are mix
  • Rohto C Cube Cool Charge ⁇ (manufactured by Rohto Pharmaceutical Co., Ltd.) was employed as an example of commercially available eye drops (artificial tears) for contact lenses.
  • This funnel C cube cool charge ⁇ contains 0.080% potassium chloride, 0.440% sodium chloride and 0.070% hydroxyethyl cellulose.
  • Other additives include boric acid, borax, polyoxy Ethylene polyoxypropylene glycol, polyoxyethylene hydrogenated castor oil, Na edetate, 1-menthol, and pH regulator are blended.
  • As the composition for contact lenses as shown in Table 2, the same compositions as in Example 8 and Comparative Example 2 used in Experimental Example 1 were used. These first liquid and contact lens composition were mixed at a volume ratio of 1: 1.
  • the details of the first liquid and the contact lens composition used are as shown in Table 3 below. That is, the multipurpose liquid for contact lenses as the first liquid employs Bioclen Zero (manufactured by Off-Tex Co., Ltd.) in the same manner as in Experimental Example 1 described above, and as the eyewash, Ivon (Kobayashi Pharmaceutical Co., Ltd.) is a commercially available eyewash. Adopted). Since the composition of bioclen zero has already been described, description thereof is omitted here.
  • Ivon an eyewash, contains 0.2% epsilon aminocaproic acid, 0.01% dipotassium glycyrrhizinate, 0.003% chlorpheniramine maleate, 0.01% pyridoxine hydrochloride (vitamin B6), tocopherol 0.005% acetate ester and 0.04% sodium chondroitin sulfate are blended.
  • Other additives include boric acid, borax, sodium edetate hydrate, polysorbate 80, l-menthol, d-Borneol and pH adjuster are blended. That is, both of these multipurpose liquids and eyewashes contain boric acid.
  • polyvinyl alcohol contained in the contact lens composition has a kinematic viscosity at 4 wt% aqueous solution, respectively 25 mm 2 / s, two types is 40 mm 2 / s is adopted.
  • Examples 11 to 16 contain either mannitol or erythritol as a low molecular polyol compound.
  • Example 4 As a first solution, an experiment was conducted to confirm the negative interaction suppression effect using a commercially available contact lens mounting solution containing polyvinyl alcohol and a contact lens composition containing boric acid. .
  • Smile Contact Fine Fit manufactured by Lion Corporation
  • other additives include Na edetate, cyclodextrin, benzalkonium chloride, and a pH adjuster. That is, this mounting solution contains polyvinyl alcohol but does not contain boric acid.
  • the composition for contact lenses was made into the composition which does not contain polyvinyl alcohol, while both an Example and a comparative example contain boric acid. Furthermore, in Example 17, mannitol was blended as a low molecular polyol compound. These first liquid and contact lens composition were mixed at a volume ratio of 1: 1, respectively, and x and a precipitate or precipitate were produced. The white turbid one was evaluated as ⁇ , and the one in which neither precipitation nor precipitation generation nor white turbidity was observed was evaluated as ⁇ . The results are shown in Table 4 below.
  • Comparative Example 5 using the composition for contact lenses that does not contain a low molecular polyol compound, the evaluation is x, and the first liquid containing polyvinyl alcohol, It can be seen that mixing with a composition for contact lenses containing boric acid results in the formation of a precipitate that is a negative interaction.
  • Example 17 using the composition for contact lenses containing mannitol as the low-molecular-weight polyol compound the evaluation is ⁇ , and the negative interaction generated in Comparative Example 5 is effectively suppressed. . That is, even when the first liquid contains polyvinyl alcohol and the contact lens composition contains boric acid, the contact lens composition contains a low-molecular polyol compound, thereby causing a negative interaction. It can be confirmed that it can be suppressed.
  • the details of the first liquid and the contact lens composition used are as shown in Table 5 below. That is, as the first-purpose multi-purpose liquid for contact lenses, Bioclen Zero (manufactured by Offtex Co., Ltd.), which is a commercially available multi-purpose liquid, was employed. Further, polyvinyl alcohol contained in the contact lens composition has a kinematic viscosity at 4 wt% aqueous solution was 5 mm 2 / s, respectively, 25 mm 2 / s, the three is 40 mm 2 / s is adopted. The first liquid and these contact lens compositions were mixed at a volume ratio of 1: 1. And the kinematic viscosity at 20 degreeC of the solution after mixing was measured using the Ubbelohde viscometer (made by Shibata Kagaku Co., Ltd.).
  • Bioclen Zero manufactured by Offtex Co., Ltd.
  • a contact lens composition having the composition shown in Table 6 below and a volume ratio of 1: 1.
  • the ratio was mixed. After immersing a test lens (Menicon Co., Ltd., Menicon 2 Week Premio) for 4 hours in this mixed solution, the lens was taken out and the liquid adhering to the lens surface was gently wiped off. Thereafter, physiological saline was dropped on the lens front curve surface, and the contact angle of the lens surface with respect to the physiological saline was measured.
  • the wettability improvement rate was calculated by the following calculation formula.
  • Table 6 shows that the comparative example 10 does not contain polyvinyl alcohol, and it is set as the negative interaction by mixing with the boric acid contained in bioclen zero does not arise.
  • Wettability improvement rate (%) ⁇ 1 ⁇ (actual value of contact angle) / (average contact angle in Comparative Example 10) ⁇ ⁇ 100
  • Examples 24 and 25 in which these polyvinyl alcohols and low molecular polyol compounds are combined are higher than those in Examples 22 and 23 in which only the low molecular polyol compounds are combined. . That is, in Examples 24 and 25, a synergistic effect was produced by combining polyvinyl alcohol and a low molecular polyol compound, and Examples 22 and 23 in which only a low molecular polyol compound was blended without including polyvinyl alcohol were obtained. The wettability is dramatically improved as compared with Comparative Example 9 in which only No is added.

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Abstract

L'invention porte sur une nouvelle composition pour des lentilles de contact, ladite composition étant apte à supprimer des interactions négatives qui ont été provoquées dans des cas où une composition classique pour des lentilles de contact et un premier liquide qui est en contact avec une lentille de contact sont mélangés et amenés en contact entre eux. La composition pour des lentilles de contact peut supprimer au moins une interaction négative parmi la formation d'un précipité, la formation d'un dépôt, la gélification, la diminution de viscosité et la diminution de la mouillabilité à l'eau d'une surface de lentille de contact, qui sont provoquées lorsqu'une composition pour des lentilles de contact et un premier liquide qui est en contact avec une lentille de contact sont mélangés et amenés en contact entre eux.
PCT/JP2009/006704 2009-12-08 2009-12-08 Composition pour lentilles de contact et procédé pour supprimer une interaction négative l'utilisant WO2011070613A1 (fr)

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PCT/JP2009/006704 WO2011070613A1 (fr) 2009-12-08 2009-12-08 Composition pour lentilles de contact et procédé pour supprimer une interaction négative l'utilisant

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014114124A1 (fr) * 2013-01-23 2014-07-31 江苏海伦隐形眼镜有限公司 Composition d'entretien de lentille de contact cornéenne contenant un sel d'ammonium quaternaire de tréhalose

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09278610A (ja) * 1996-04-16 1997-10-28 Ofutekusu:Kk 有害微生物防除用組成物
JP2000314856A (ja) * 1999-04-30 2000-11-14 Hoya Health Care Kk コンタクトレンズ用洗浄剤
JP2003089601A (ja) * 2001-09-17 2003-03-28 Menicon Co Ltd 殺菌液
JP2004269508A (ja) * 2003-02-20 2004-09-30 Lion Corp コンタクトレンズ取り外し液及びコンタクトレンズの取り外し方法
JP2005187345A (ja) * 2003-12-24 2005-07-14 Lion Corp コンタクトレンズ装着液
JP2009175543A (ja) * 2008-01-25 2009-08-06 Menicon Co Ltd コンタクトレンズ用液剤及びコンタクトレンズ並びにコンタクトレンズに対する殺菌剤の付着防止方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09278610A (ja) * 1996-04-16 1997-10-28 Ofutekusu:Kk 有害微生物防除用組成物
JP2000314856A (ja) * 1999-04-30 2000-11-14 Hoya Health Care Kk コンタクトレンズ用洗浄剤
JP2003089601A (ja) * 2001-09-17 2003-03-28 Menicon Co Ltd 殺菌液
JP2004269508A (ja) * 2003-02-20 2004-09-30 Lion Corp コンタクトレンズ取り外し液及びコンタクトレンズの取り外し方法
JP2005187345A (ja) * 2003-12-24 2005-07-14 Lion Corp コンタクトレンズ装着液
JP2009175543A (ja) * 2008-01-25 2009-08-06 Menicon Co Ltd コンタクトレンズ用液剤及びコンタクトレンズ並びにコンタクトレンズに対する殺菌剤の付着防止方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014114124A1 (fr) * 2013-01-23 2014-07-31 江苏海伦隐形眼镜有限公司 Composition d'entretien de lentille de contact cornéenne contenant un sel d'ammonium quaternaire de tréhalose

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