WO2011070613A1

WO2011070613A1 - Composition for contact lenses and method for suppressing negative interaction using same

Info

Publication number: WO2011070613A1
Application number: PCT/JP2009/006704
Authority: WO
Inventors: 塚本桂史; 谷川定康; 小川晋
Original assignee: 株式会社メニコン
Priority date: 2009-12-08
Filing date: 2009-12-08
Publication date: 2011-06-16

Abstract

Disclosed is a novel composition for contact lenses, which is capable of suppressing negative interactions that have been caused in cases where a conventional composition for contact lenses and a first liquid that is in contact with a contact lens are mixed and brought into contact with each other. The composition for contact lenses can suppress at least one negative interaction among the formation of a precipitate, the formation of a deposit, the gelation, the decrease in the viscosity, and the decrease in the water wettability of a contact lens surface which are caused when a composition for contact lenses and a first liquid that is in contact with a contact lens are mixed and brought into contact with each other.

Description

Contact lens composition and method of suppressing negative interaction using the same

The present invention relates to a composition for contact lenses and a method for suppressing negative interaction using the composition.

The contact lens is in contact with various liquids from the time it is manufactured until it is used by the user and during the period of use by the user. Specifically, for example, from manufacturing to use by the user, it is stored in a package soaked in the packaging solution, and when used by the user, it comes into contact with contact lens mounting solution or eye drops. It becomes. Furthermore, when the user cleans the worn contact lens, the user comes into contact with the contact lens multipurpose liquid, sterilizing liquid, cleaning liquid, rinsing liquid, and the like, and then stored in a liquid such as a storage liquid. As described above, various liquids come into contact with the contact lens on a daily basis, and in the process, various liquids are often mixed and contacted with the contact lens.

On the other hand, as a contact lens composition for reducing the feeling of foreign matter and dryness when wearing a contact lens, cited reference 1 (Japanese Patent Application Laid-Open No. 2004-77953) and cited reference 2 (Japanese Patent Application Laid-Open No. 2006-2007). No. 39529), cited reference 3 (Japanese Patent Laid-Open No. 2003-107416), and the like are considered. Moreover, the composition for contact lenses described in the cited reference 4 (patent 4267673) etc. are also devised as what stabilized viscosity more than these compositions for contact lenses.

However, when such a contact lens composition is actually used by users, various undesired phenomena such as white turbidity, precipitation, and gelation of the solution may occur due to some cause. is there. The inventors have intensively studied the cause, and when these contact lens compositions are actually used by the user, the contact lens composition is in contact with other liquids in contact with the contact lens. It has been found that this is because an undesirable interaction (negative interaction) occurs with the other liquids by mixing.

That is, a contact lens composition such as a mounting liquid used in contact with a contact lens is mixed with various liquids that come into contact with other contact lenses in actual use. Specifically, for example, when the mounting liquid is dropped on the contact lens before wearing, various liquids already in contact with the contact lens, for example, multipurpose liquids for contact lenses, packaging solutions, protein washing / removal The agent, the preserving liquid, the cleaning liquid, the rinsing liquid, and the mounting liquid come into contact with each other and are mixed with each other. Furthermore, in a state where the user wears the contact lens to which the wearing solution is dropped, the wearer's tear fluid, eye drops, eye wash, and the like are brought into contact and mixed. In other cases, two or more eye drops may be used in combination, or a protein washing / removing agent may be added to the preservation solution.

As described above, undesired interactions caused by the contact contact between the contact lens composition and other liquids that occur when using the contact lens composition such as a mounting liquid, that is, the formation of precipitates and precipitates, solutions The occurrence of various undesirable phenomena such as gelation has not been regarded as a problem so far. Therefore, no countermeasure has been devised for the method of suppressing such a phenomenon.

JP 2004-77953 A JP 2006-39529 A JP 2003-107416 A Japanese Patent No. 4267673

Here, the present invention has been made in the background as described above, and the problem to be solved is that the first liquid that comes into contact with the contact lens and the composition for contact lens are mixed and contacted. An object of the present invention is to provide a novel composition for contact lenses that can suppress the occurrence of negative interactions caused by the above.

Furthermore, an object of the present invention is to provide a novel method for suppressing such negative interaction.

Hereinafter, embodiments of the present invention made to solve the above-described problems will be described. In addition, the component employ | adopted in each aspect as described below is employable by arbitrary combinations as much as possible.

That is, the first aspect of the present invention relating to a contact lens composition is a multipurpose solution for contact lenses, a bactericidal solution, a cleaning solution, a protein cleaning / removing agent, a preserving solution, a rinsing solution, an ophthalmic solution, an eyewash solution, a mounting solution, a packaging. A contact lens composition that is mixedly contacted with a first liquid that comes into contact with a contact lens selected from at least one of a solution, a hydration treatment liquid, and a tear fluid. It is characterized in that at least one negative interaction among the formation of precipitates, the formation of precipitates, gelation, the decrease in viscosity, and the reduction in water wettability of the contact lens surface, which are generated by mixed contact with the water, is suppressed. And

According to the composition for contact lenses according to the present invention, for example, even if the contact lens composition such as a mounting liquid or eye drops is mixed and contacted with the first liquid such as the multipurpose liquid for contact lenses, Contact lenses associated with such negative interactions can be suppressed by suppressing the occurrence of negative interactions, that is, the formation of precipitates, the formation of precipitates, gelation, reduction in viscosity, reduction in water wettability of contact lens surfaces, etc. It is possible to prevent the appearance of foreign matter and dryness during wearing, and it is possible to prevent the wearing feeling from being lowered. In addition, by suppressing the occurrence of such negative interactions, the physical properties of the composition for contact lenses and the solution characteristics of the first liquid are prevented from being deteriorated, and the respective desired effects are exhibited well. Can do. Moreover, according to the present invention, in addition to the above-described phenomenon such as the formation of precipitates, it is possible to suppress negative interactions such as a decrease in bactericidal efficacy and a decrease in drug efficacy.

A second aspect of the present invention relating to a contact lens composition is characterized in that the contact lens composition according to the first aspect includes a low-molecular polyol compound.

According to this aspect, it is possible to suitably suppress the negative interaction (precipitation generation or the like) caused by the mixed contact between the contact lens composition and the first liquid.

It is not clear why various negative interactions occur due to the mixed contact between the contact lens composition such as the conventional mounting liquid and the first liquid such as the multipurpose liquid for contact lenses. One possible cause is that a component such as boric acid contained in the first liquid and the like and a component contained in the contact lens composition form a network due to hydrogen bonding or the like during mixing. It is thought that. According to this embodiment, the hydroxyl group (—OH) of the low-molecular polyol compound intervenes and inhibits the formation of a network due to such a hydrogen bond, thereby causing precipitation, cloudiness, gelation, etc. It is thought that the phenomenon can be suppressed.

In addition, the water wettability of the contact lens surface can be improved by blending the low molecular polyol compound according to this embodiment. Thereby, a dry feeling at the time of wearing a contact lens can be prevented, and the wearing feeling can be further improved.

Three aspects of the present invention relating to a contact lens composition are the contact lens composition according to the second aspect, wherein the low-molecular polyol compound is glucose, sucrose, lactose, maltose, trehalose, erythritol, xylitol, multi It contains at least one selected from Toll, Mannitol, and Sorbitol.

According to this embodiment, the negative interaction caused by the mixed contact between the contact lens composition and the first liquid can be particularly suitably suppressed. That is, by adopting the above-mentioned sugar and / or sugar alcohol as the low molecular weight polyol compound, negative effects caused between the components of the composition for contact lenses and the components such as boric acid contained in the first liquid. Can be particularly preferably inhibited, and as a result, it is possible to effectively prevent a decrease in wearing feeling due to the occurrence of precipitation or the like.

A fourth aspect of the present invention relating to a contact lens composition is characterized in that the contact lens composition according to any one of the first to third aspects includes a polymer polyol compound.

According to this aspect, the viscosity of the contact lens composition can be effectively improved, and the wearing feeling of the contact lens can be further improved. That is, in the conventional contact lens composition, the polymer polyol compound has been blended for the purpose of increasing the viscosity and improving the wearing feeling, but the polymer polyol compound is used as the first liquid. When mixed and contacted, negative interactions such as the formation of precipitates and a decrease in viscosity occur between the components of the first liquid and the polymer polyol compound, and the feeling of wearing may decrease on the contrary. . However, according to this embodiment, even when a polymer polyol compound is blended, the negative interaction with the first liquid can be suppressed, so that a decrease in viscosity and the like can be prevented, and the wearing feeling of the contact lens can be prevented. Can be improved effectively. In addition, as for this aspect, it is desirable to employ | adopt in combination with the above-mentioned 2nd or 3rd aspect. And if this aspect is adopted in combination with these second or third aspects, the wettability of the contact lens surface is particularly preferably improved, so that the wearing feeling of the contact lens can be further improved.

A fifth aspect of the present invention relating to a contact lens composition is the contact lens composition according to the fourth aspect, wherein the polymer polyol compound has a kinematic viscosity of 30 mm ² / s or less in a 4% by weight aqueous solution. It is characterized by being a certain polyvinyl alcohol.

According to this aspect, while improving the viscosity of the composition for contact lenses by the action of polyvinyl alcohol, it is possible to particularly effectively prevent the negative interaction with the first liquid and to improve the wearing feeling well. In other words, if polyvinyl alcohol having a kinematic viscosity of 30 mm ² / s or less in a 4% by weight aqueous solution is employed, for example, both of the generation of precipitation due to negative interaction with the first liquid and the decrease in viscosity are suppressed. it can.

In addition, the first aspect of the present invention relating to a method for suppressing negative interactions is a multipurpose solution for contact lenses, a bactericidal solution, a washing solution, a protein washing / removing agent, a preserving solution, a rinsing solution, an ophthalmic solution, an eyewash solution, and an attachment A negative liquid generated by mixing and contacting a contact lens composition with a first liquid that contacts a contact lens selected from at least one of a liquid, a packaging solution, a hydration solution, and a tear fluid A method for suppressing interaction, wherein the contact lens composition according to any one of claims 1 to 5 is used as the contact lens composition, and mixed contact with the first liquid is performed. The negative interaction is characterized by suppressing at least one of precipitate formation, precipitate formation, gelation, viscosity reduction, and contact lens surface water wettability reduction.

According to this aspect, by using the contact lens composition according to any one of the first to fifth aspects of the present invention related to the contact lens composition described above, a first contact with the contact lens is achieved. Negative interaction due to mixed contact between the liquid and the contact lens composition can be suppressed, and deterioration of wearing feeling, deterioration of liquidity, and the like can be prevented.

In addition, the second aspect of the present invention relating to a method for suppressing negative interaction is a multipurpose solution for contact lenses, a bactericidal solution, a washing solution, a protein washing / removing agent, a preservation solution, a rinsing solution, an ophthalmic solution, an eyewash solution, and a wearing A negative liquid generated by mixing and contacting a contact lens composition with a first liquid that contacts a contact lens selected from at least one of a liquid, a packaging solution, a hydration solution, and a tear fluid A method for suppressing interaction, wherein the contact lens composition is at least one selected from low molecular polyol compounds consisting of glucose, sucrose, lactose, maltose, trehalose, erythritol, xylitol, maltitol, mannitol, sorbitol. The negative contact due to the mixed contact with the first liquid. As interactions, formation of precipitation, precipitate formation, gelation, reduction in viscosity, to suppress at least one of the water-reducing wettability of the contact lens surface, characterized.

According to this aspect, by using the composition for contact lenses containing the low molecular polyol compound, negative interaction due to the mixed contact between the first liquid contacting the contact lenses and the composition for contact lenses is suppressed. be able to.

According to the present invention, even if the first liquid that contacts the contact lens and the contact lens composition are mixed and contacted, the formation of precipitates, the formation of precipitates, gelation, the decrease in viscosity, the contact lens surface Negative interactions such as reduced water wettability are suppressed. Thereby, it is possible to prevent a decrease in wearing feeling of the contact lens due to the negative interaction.

Hereinafter, in order to clarify the present invention more specifically, embodiments of the present invention related to a contact lens composition and a method for suppressing negative interaction will be described in detail.

The contact lens composition as one embodiment of the present invention relating to a contact lens composition is a multipurpose solution for contact lenses, a bactericidal solution, a cleaning solution, a protein cleaning / removing agent, a storage solution, a rinsing solution, an ophthalmic solution, an eyewash solution, It is used after being mixed and contacted with a first liquid that comes into contact with a contact lens selected from at least one of a mounting liquid, a packaging solution, a hydration treatment liquid, and a tear liquid. And the composition for contact lenses according to the present embodiment also reduces the formation of precipitates, the formation of precipitates, gelation, the decrease in viscosity, and the water wettability of the contact lens surface by mixing contact with the first liquid. At least one of these negative interactions can be suppressed. First, in order to facilitate understanding of the characteristics of such a contact lens composition, the first liquid referred to in the present embodiment, the first liquid, The negative interaction that occurs in mixed contact with a conventional contact lens composition will be described.

Conventionally, various contact lens compositions have been considered as contact lens mounting solutions, eye drops, and the like. Such a contact lens composition, such as a mounting solution, has many opportunities to come into contact with other contact lens solutions such as a storage solution. Specifically, for example, the mounting liquid is often used by being dropped onto a contact lens immediately before wearing, but the storage liquid or cleaning liquid adhered to the contact lens immediately before wearing when it is taken out from a storage container or the like. Or a mixture thereof is in contact. When the mounting liquid is dropped onto such a contact lens, the mounting liquid comes into contact with the storage liquid, the cleaning liquid, and the like on the lens surface and is mixed.

Then, when the contact lens composition and the first liquid are mixed in this way, in the conventional contact lens composition, the components included in the contact lens composition and the components included in the first liquid May cause undesired phenomena such as formation of precipitates, formation of precipitates, gelation, decrease in viscosity, and reduction in water wettability of contact lens surfaces. In the present embodiment, these unfavorable phenomena such as the formation of precipitates, the formation of precipitates, gelation, reduction in viscosity, and reduction in water wettability of the contact lens surface are collectively referred to as negative interactions. If such a negative interaction occurs, there is a risk that an unpleasant phenomenon will be caused to the user, such as a feeling of foreign matter or dryness when the contact lens is worn, or a blurred field of view. In addition, when negative interaction occurs, for example, the contact lens composition as a mounting liquid has an effect such as improvement of water wettability that is aimed at, or the first liquid has a buffering action. There is a possibility that the various effects of the decrease.

It is not yet clear why such a negative interaction occurs. However, such a negative interaction is particularly caused by boric acid in at least one of the first liquid and the contact lens composition. On the other hand, the inventors have clarified that polyvinyl alcohol is contained and is likely to occur when these are mixed. Boric acid is a general substance added to many contact lens solutions as a buffer and preservative, and polyvinyl alcohol as a thickener. When such a first liquid containing boric acid or polyvinyl alcohol and the composition for contact lenses are mixed, some negative interaction such as formation of precipitates or gelation is particularly likely to occur. As a result, it is impossible to obtain the desired buffering action and improvement of wearing feeling. In addition, negative interactions such as the formation of precipitates and precipitates, gelation, and reduction of wettability can occur not only by mixing boric acid and polyvinyl alcohol, but also by combining various other substances. .

Here, the composition for contact lenses according to the present embodiment can suitably suppress the negative interaction caused by the mixed contact between the first liquid and the composition for contact lenses. Below, this embodiment is explained in full detail.

First, as a contact lens in this embodiment, a hard contact lens, an oxygen permeable hard contact lens, a soft contact lens, a silicone hydrogel soft contact lens, a hybrid contact lens (a combination of an oxygen permeable hard contact lens and a soft contact lens) Well-known contact lenses such as contact lenses), orthokeratology lenses, fashionable color contact lenses, and the like are used without particular limitation. Further, the usage form of the contact lens is not particularly limited. That is, it may be a disposable contact lens that is used only for a short period such as one day or one week to several months, or a normal contact lens that is used for a longer period.

When the contact lens composition is mixed and contacted with the first liquid described later, the contact lens composition has at least one negative effect of precipitation formation, precipitate formation, gelation, viscosity reduction, and contact lens surface water wettability reduction. It has a composition that can suppress the interaction.

The specific composition of the contact lens composition is not particularly limited as long as negative interaction can be suppressed, but preferably, for example, a low molecular polyol compound is blended in the contact lens composition. The Thereby, the negative interaction with the first liquid can be particularly suitably suppressed. In addition, such a low molecular polyol compound suppresses the negative interaction by mixing boric acid in at least one of the contact lens composition and the first liquid and polyvinyl alcohol in the other. In particular, it is particularly effective. However, the negative interaction suppression effect by the low-molecular polyol compound works effectively even for negative interactions caused by causes other than mixing of boric acid and polyvinyl alcohol. In addition, by blending the low molecular polyol compound with the contact lens composition, the wettability of the contact lens is also improved, so that the wearing feeling of the contact lens is also improved.

As the low molecular polyol compound, in particular, a compound selected from at least one of glucose, sucrose, lactose, maltose, trehalose, erythritol, xylitol, maltitol, mannitol, and sorbitol is desirably employed. By adopting these sugars and / or sugar alcohols, negative interactions can be particularly effectively suppressed while preventing eye irritation and effects on physical properties of contact lenses. In addition, as for a low molecular polyol compound, only 1 type of the above-mentioned substance may be employ | adopted, and 2 or more types may be combined and employ | adopted. Moreover, glucose, trehalose, erythritol, mannitol, and sorbitol are preferably employed, more preferably erythritol and mannitol are employed, and most preferably mannitol is employed.

Such a low-molecular polyol compound is desirably blended at a concentration of 0.1 to 10% by weight, and more desirably at a concentration of 0.5 to 5% by weight. If the concentration is within such a range, the negative interaction can be suppressed particularly effectively. That is, even if the concentration is increased to more than 10% by weight, the negative interaction suppressing effect becomes flat and waste may occur. Furthermore, when the osmotic pressure increases, there may be a case where the contact lens specification changes or eye irritation occurs. On the other hand, when the concentration is less than 0.1% by weight, there is a possibility that the effect of suppressing the negative interaction cannot be sufficiently obtained.

When the low molecular polyol compound is blended in combination with a high molecular polyol compound such as polyvinyl alcohol described later, the concentration ratio of the high molecular polyol compound to the low molecular polyol compound is 1: 1 to 1:10 ( High molecular polyol compound: low molecular polyol compound) is preferable. By blending the low-molecular polyol compound at such a concentration ratio, a more desirable negative interaction suppression effect can be obtained.

The causes of various negative interactions caused by the mixed contact between the conventional contact lens composition and the first liquid, and the mechanism by which such negative interactions are suppressed by the blending of the low molecular polyol compound are as follows. Although not yet clear, the following hypothesis is considered as one guess. For example, in the mixed contact of the contact lens composition containing polyvinyl alcohol and the first liquid containing boric acid, boric acid contained in the first liquid and the like, polyvinyl alcohol contained in the contact lens composition, etc. One of the causes is considered to form a network due to hydrogen bonding or the like during mixing. Then, according to the present embodiment, for example, a low molecular polyol compound such as mannitol is blended in the contact lens composition, so that the hydroxyl group (—OH) of the low molecular polyol compound is involved in the formation of a network by hydrogen bonding. Therefore, it is speculated that the formation can be inhibited, and as a result, negative interactions such as precipitation, cloudiness, and gelation can be suppressed.

The low-molecular polyol compound such as mannitol described above is blended particularly when boric acid is blended in one of the contact lens composition and the first liquid and polyvinyl alcohol is blended in the other. In addition, it is possible to particularly effectively prevent the negative interaction due to the mixture of boric acid and polyvinyl alcohol.

The present embodiment is particularly preferably applied to a contact lens composition containing a polymer polyol compound such as polyvinyl alcohol. That is, the composition for contact lenses is often blended with a polymer polyol compound such as polyvinyl alcohol as a thickener for improving the viscosity of the composition for contact lenses. However, when such a polymer polyol compound is mixed with a first liquid containing boric acid or the like, negative interactions such as precipitation, white turbidity, and gelation occur. Wearing feeling may be greatly reduced. In particular, in the case where the first liquid contains boric acid, it is known that when the first liquid is mixed with the composition for contact lenses containing polyvinyl alcohol, a negative interaction such as formation of a precipitate occurs. However, according to the present embodiment, even if the contact lens composition containing a polymer polyol compound such as polyvinyl alcohol and the first liquid containing boric acid are mixed and contacted, the contact lens composition has mannitol or the like. Negative interaction can be suppressed, for example, by blending the low molecular polyol compound. As a result, the thickening action of the polymer polyol compound can be sufficiently exerted.

Furthermore, when such a high-molecular polyol compound is combined with the aforementioned low-molecular polyol compound, the wettability of the contact lens is greatly enhanced by the synergistic effect. That is, the low-molecular polyol compound has an effect of improving the wettability to some extent in addition to the action of suppressing the negative interaction, but the wettability is further increased by blending it with the high-molecular polyol compound. It is. Therefore, by combining a high-molecular polyol compound and a low-molecular polyol compound in combination, the wettability of the contact lens is greatly improved and the formation of gelation and precipitation due to the interaction with the first liquid is suppressed. This can advantageously improve the wearing feeling of the contact lens. Therefore, it is desirable that the composition for contact lenses according to the present embodiment contains a polymer polyol compound.

The specific composition of the polymer polyol compound is not particularly limited, and specifically, for example, polyalkylene glycols such as polyethylene glycol and polypropylene glycol, polyoxyethylene polyoxypropylene block copolymer, polyoxyethylene poly Polyoxyalkylenes such as oxypropylene ethylenediamine, glycerin derivatives such as polyglycerin and polyglycerin esters, vinyl polymers such as polyvinyl alcohol, polysaccharides such as galactomannan, glucomannan, and pullulan can be employed. In addition, only 1 type of these polymer polyol compounds may be employ | adopted, and 2 or more types may be combined and employ | adopted. Of these substances, polyvinyl alcohol is most preferably used.

In addition, when employ | adopting polyvinyl alcohol as a high molecular polyol compound, it is desirable to employ | adopt polyvinyl alcohol whose kinematic viscosity in 4 weight% aqueous solution is 30 mm < ² > / s or less. When such polyvinyl alcohol is employed, even when the first liquid contains boric acid, the negative interaction that is considered to be mainly caused by the interaction between boric acid and polyvinyl alcohol is suppressed particularly effectively. For example, it is possible to suppress both of the two phenomena of formation of precipitation and decrease in viscosity. In addition, the value of kinematic viscosity in this embodiment is a numerical value prescribed | regulated according to the viscosity measuring method of polyvinyl alcohol (partial saponification) defined by the pharmaceutical additive specification. Specifically, a 4% by weight aqueous solution was measured at 20 ° C. using an Ubbelohde viscometer.

The concentration of the polymer polyol compound is 0.01 to 5% by weight, preferably 0.1 to 3% by weight, and more preferably 0.2 to 2% by weight. When the concentration is within such a range, the negative interaction can be particularly effectively suppressed. That is, when the concentration is more than 5% by weight, the negative interaction may not be sufficiently suppressed. On the other hand, when the concentration is less than 0.01% by weight, the effect of improving the wettability by the combination with the thickening action or the low molecular polyol compound may not be sufficiently exhibited.

The contact lens composition according to the present embodiment, for example, a contact lens multipurpose solution, a bactericidal solution, a cleaning solution, a protein cleaning / removing agent, a preserving solution, a rinsing solution, and an ophthalmic solution, as long as the inhibitory effect of negative interaction is not limited. As a solution for contact lenses, such as eyewash, mounting solution, packaging solution, hydration solution, etc., it can be used without any particular limitation. Furthermore, it may have a plurality of forms as a combination of the above forms such as contact lens mounting liquid and eye drops or eye drops and eye wash. The present embodiment is particularly suitably applied as a contact lens mounting solution, an eye drop solution, a packaging solution, and a contact lens multipurpose solution.

Further, the specific composition of the substance to be blended in the contact lens composition is not particularly limited as long as the negative interaction suppressing effect is not limited. For example, any composition known in the art as a contact lens multipurpose solution, bactericidal solution, cleaning solution, protein cleaning / removing agent, preserving solution, rinsing solution, eye drops, eyewash solution, mounting solution, packaging solution, hydration solution, etc. Can also be employed.

Therefore, more specifically, other additives can be appropriately added to the contact lens composition in addition to the above-described high-molecular polyol compound and low-molecular polyol compound. That is, known buffers, pH adjusters, preservatives / bactericides, surfactants, thickeners, tonicity agents, chelating agents, wetting agents, stabilizers, perfumes or cooling agents that can be included in each of the above liquids An agent, a drug, an antibacterial agent, vitamins, and the like can be blended in one or a combination of two or more.

In addition, the above-mentioned low molecular polyol compound can also act as, for example, an isotonic agent in addition to the above-described action of suppressing the negative interaction. Therefore, the contact lens composition may be composed of only a low molecular polyol compound or a high molecular polyol compound, or may be added in combination with other additives.

Examples of the buffer include boric acid, borax and borate buffer, carbonate buffer, citric acid and citrate buffer, carboxylic acids such as acetic acid, acids such as oxycarboxylic acid and salts thereof, aminoethyl Amino acids such as sulfonic acid, glycine, arginine, glutamic acid, ε- aminocaproic acid, 2-amino-2-methyl-1,3-propane (AMP) buffer, tris (hydroxymethyl) aminomethane (Tris) buffer, Bis (2-hydroxyethyl) iminotris (hydroxymethyl) methane (Bis-Tris), phosphoric acid and phosphate buffer, Good-Buffer, and the like.

Examples of the pH adjusting agent include hydrochloric acid, citric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogen carbonate, sodium hydrogen phosphate, sodium dihydrogen phosphate, phosphates, sulfuric acid and the like. .

Examples of preservatives and bactericides include sorbic acid, potassium sorbate, benzoic acid or salts thereof, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, chlorobutanol, benzalkonium chloride, Polyhexamethylene biguanide (PHMB; polyhexanide hydrochloride), alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride (CPC), chlorhexidine, alexidine, chlorpheniramine or its salts, allantoin, chlorine dioxide, sodium perborate, polydronium chloride, etc. And the like.

As the surfactant, any of the conventionally known anionic surfactants, nonionic surfactants, and amphoteric surfactants can be appropriately employed. Glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl phenyl ether formaldehyde condensate, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl phenyl ether, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbite fatty acid ester, poly Oxyethylene castor oil, polyoxyethylene sterol, polyoxyethylene hydrogenated sterol, polyoxyethylene fatty acid ester, polyoxyethylene polyoxypropylene alkyl ether, polio Siethylene lanolin alcohol, polyoxyethylene alkylamine, polyoxyethylene alkylamide, polyoxyethylene alkyl ether phosphate, polysorbate, polyoxyethylene alkyl ether carboxylate, polyoxyethylene alkyl ether sulfate, alkyl fatty acid salt, alkyl phosphorus Acid salt, N-acyl taurine salt, alkyl glutamate salt, alkyl glycine salt, alkyl alanine salt, cocoyl fatty acid arginine, alkyl sulfate salt, alkyl sulfonate salt, betaine acetate type double active agent, alkyloxyhydroxypropyl arginine salt, cocoyl arginine salt Examples include ethyl PCA.

Examples of the thickener include synthetic organic polymer compounds such as polyvinylpyrrolidone, polyacrylamide, poly (meth) acrylic acid, and Copolymer 845 (copolymer of polyvinylpyrrolidone and dimethylaminoethyl methacrylate), methylcellulose, ethylcellulose, and hydroxymethylcellulose. , Cellulose derivatives such as hydroxypropylmethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, carboxyethylcellulose, starch derivatives, polysaccharides such as alginic acid, chitosan and their salts, various gums such as heteropolysaccharides, hyaluronic acid (salts) ), Mucopolysaccharides such as chondroitin sulfate (salt), and the like.

Examples of tonicity agents include inorganic salts such as sodium chloride, potassium chloride, sodium bisulfite, sodium sulfite, magnesium chloride, potassium acetate, sodium acetate, sodium thiosulfate, and magnesium sulfate, and polyhydric alcohols such as propylene glycol and glycerin. Alternatively, ethers or esters thereof may be mentioned.

Examples of the chelating agent include ethylenediaminetetraacetic acid (EDTA) and salts thereof, ethylenediaminetetraacetic acid · disodium (EDTA · 2Na), ethylenediaminetetraacetic acid · 3sodium (EDTA · 3Na), ethylenediaminetetraacetic acid · 4sodium (EDTA · 4Na). ), Phytic acid, citric acid and the like.

Examples of the wetting agent include cellulose derivatives such as cationized cellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose and methylcellulose, lower or higher alcohols such as ethanol, isopropanol, oleyl alcohol and lauryl alcohol, almond oil, lanolin, olive oil, oleic acid and And / or its salts, oils and fats such as liquid paraffin, triglyceride, squalane, petrolatum, silicone oil, sesame oil, perilla oil, soybean oil, camellia oil, jojoba oil, corn oil, castor oil and the like.

Stabilizers include ascorbic acid, sodium edetate, cyclodextrin, condensed phosphoric acid, sulfite, citric acid, dibutylhydroxytoluene, trometamol, sodium formaldehyde sulfoxylate (Longalite), tocopherol, sodium pyrosulfite, monoethanolamine, Examples thereof include aluminum monostearate.

Examples of the fragrance or refreshing agent include anethole, eugenol, camphor, chlorobutanol, geraniol, cineol, borneol, menthol, limonene, ryuunou, fennel oil, cool mint oil, cinnamon oil, spearmint oil, peppermint water, peppermint oil, peppermint Oil, bergamot oil, eucalyptus oil, rose oil and the like.

Examples of the drug include cromoglycic acid, tranilast, chlorpheniramine maleate, diphenhydramine hydrochloride, amlexanox, ibudilast, pemirolast potassium, emedastine fumarate, ketotifen fumarate, olopatadine hydrochloride, ebastine, acitazanolast, levocabastine hydrochloride, etc. Anti-allergic agents, glycyrrhizic acid and its salts, ε-aminocaproic acid, allantoin, sodium azulenesulfonate, berberine chloride, berberine sulfate, zinc sulfate, zinc lactate, lysozyme, fluorometholone and other anti-inflammatory agents Blood vessels such as epinephrine, epinephrine hydrochloride, epinephrine hydrochloride, ephedrine hydrochloride, naphazoline hydrochloride, naphazoline nitrate, phenylephrine hydrochloride, tetrahydrozoline hydrochloride Agents, focusing function improving agent such as neostigmine methylsulfate, betaxolol, timolol, dipivefrin, carteolol, Ratanopurasuto, Tafurupurasuto, Torabopurasuto, nipradilol, include ocular hypotensive agents such as Rebobunoru.

Antibacterial agents include, for example, sulfamethoxazole, sulfamethoxazole sodium, sulfisoxazole, sulfisomidine sodium and other sulfa drugs, ofloxacin, norfloxacin, levofloxacin, gatifloxacin, moxifloxacin, tosufloxacin New quinolone antibacterial agents such as romefloxacin and ciprofloxacin, aminoglycoside antibacterial agents such as tobramycin, gentamicin, micronomycin, dibekacin and sisomycin, tetracycline antibacterial agents such as tetracycline and minocycline, and macrolide antibacterial agents such as erythromycin And chloramphenicol antibacterial agents such as chloramphenicol, and cephem antibacterial agents such as cefmenoxime.

Examples of vitamins include vitamin A (including retinol palmitate, β-carotene, etc.), vitamin B2 (flavin adenine nucleotide, etc.), vitamin B6 (pyridoxine hydrochloride, etc.), vitamin B12 (cyanocobalamin, etc.), vitamin C ( Ascorbic acid and the like), vitamin Es (acetic acid-d-α-tocopherol and the like), panthenol and the like.

On the other hand, the first liquid is a liquid used in contact with a contact lens, and is a multipurpose liquid for contact lenses, a bactericidal liquid, a cleaning liquid, a protein cleaning / removing agent, a preserving liquid, a rinsing liquid, an eye drop, an eye wash, It is a liquid selected from at least one of a mounting liquid, a packaging solution, a hydration liquid, and a tear liquid.

Such first liquid is the above-mentioned contact lens multipurpose liquid, bactericidal liquid, cleaning liquid, protein cleaning / removing agent, preserving liquid, rinsing liquid, eye drops, eyewash liquid, mounting liquid, packaging solution, hydration liquid In addition, it may be configured to include only one kind of tears, or may be configured to include two or more kinds. Specifically, for example, a known cleaning liquid that exhibits only a cleaning action may be used, or a cleaning storage liquid that has both a cleaning action and a storage action may be used. Further, for example, a liquid obtained by mixing a known cleaning liquid and a storage liquid may be used. Further, it may be an ophthalmic solution remaining in the conjunctival sac or a liquid agent obtained by mixing a multipurpose agent for contact lenses and tear fluid in the anterior ocular segment.

In addition, the specific composition of the first liquid is not particularly limited as long as it does not limit the effect of suppressing the negative interaction of the contact lens composition. That is, the composition of known multipurpose liquids for contact lenses, bactericidal liquids, cleaning liquids, protein cleaning / removing agents, preservative liquids, rinsing liquids, eye drops, eyewash liquids, mounting liquids, packaging solutions, hydrating liquids, tears liquids, As long as the inhibitory effect of the negative interaction of the composition for contact lenses is not limited, it can be arbitrarily adopted.

Therefore, more specifically, the first liquid is a known buffer, pH adjuster, preservative / bactericidal agent, surfactant, thickener, isotonic agent, which can be included in each of the above liquids, A chelating agent, a wetting agent, a stabilizer, a fragrance or a refreshing agent, a drug, an antibacterial agent, vitamins, and the like may be used alone or in combination. In addition, as specific components of these additives, any of the additives that can be employed in the contact lens composition exemplified above can be employed without any particular limitation. To do.

And the composition for contact lenses according to this embodiment is suitably used especially for the first liquid composed of boric acid as a buffering agent and an antiseptic / bactericidal agent. That is, when the first liquid containing boric acid is mixed with a contact lens composition containing a polymer polyol compound such as polyvinyl alcohol, negative interactions such as formation of precipitation and gelation are caused. It is likely to occur. However, when the composition for contact lenses according to this embodiment is used, even if the first liquid contains boric acid and the composition for contact lenses contains polyvinyl alcohol, the composition for contact lenses is used. By including a low molecular polyol compound or the like, generation of negative interaction can be suppressed. As a result, it is possible to prevent irritation to the eyes of the user due to precipitates and the like, and it is also possible to prevent the boric acid buffering action, antiseptic action and bactericidal action contained in the first liquid from being inhibited.

However, the negative interaction referred to in the present embodiment is not limited to that caused by the interaction between boric acid and polyvinyl alcohol. That is, the negative interaction can occur as a result of the mixed contact between the first liquid and the contact lens composition. Precipitate formation, precipitate formation, gelation, viscosity reduction, contact lens surface water wetting It is sufficient that the action includes at least one of the property reductions, and it is not limited to a specific phenomenon due to mixing of specific substances.

The first liquid only needs to be a solution that comes into contact with the contact lens at any stage. When the first liquid and the contact lens composition are mixed, the first liquid is contacted. The lens may be in direct contact or may not be in contact. That is, the first liquid may contact the contact lens before or after the first liquid and the contact lens composition are mixed and contacted. Moreover, the specific aspect in which the first liquid and the contact lens composition are mixed and contacted is not particularly limited. For example, in a state where the first liquid is stored in a storage container or the like together with the contact lens, the contact liquid composition is added thereto, so that the first liquid and the contact lens composition are mixed and brought into contact with each other. The contact lens composition may be mixed with the first liquid before the contact lens is immersed in the first liquid or when the contact lens is removed from the first liquid. May be. Alternatively, the first liquid and the contact lens composition may be in contact with each other in the vicinity of the user's cornea while the contact lens is attached to the user's eye.

In addition, the composition for contact lenses according to the present embodiment can be generated as a result of mixing the first liquid and the composition for contact lenses, formation of precipitates, formation of precipitates, gelation, decrease in viscosity, contact lens surface As long as it can suppress at least one action of reducing the wettability of water, only one negative interaction among these phenomena may be suppressed, or two or more It may be one that can suppress any negative interaction.

In addition, the first embodiment of the present invention relating to a method for suppressing negative interaction is suitably implemented by using the contact lens composition according to one embodiment of the present invention relating to the above-described contact lens composition. The First, at least one of contact lens multipurpose liquid, bactericidal liquid, cleaning liquid, protein cleaning / removing agent, preservative liquid, rinsing liquid, eye drops, eyewash liquid, mounting liquid, packaging solution, hydration liquid, and tear liquid As the first liquid that contacts the contact lens selected from the above, it is desirable to employ the first liquid according to one embodiment of the present invention relating to the above-described composition for contact lenses. And the composition for contact lenses according to one Embodiment of this invention regarding the composition for contact lenses mentioned above is mixed-contacted with such a 1st liquid. As a result, at least one of precipitation generation, precipitate generation, gelation, viscosity reduction, and water wettability reduction of the contact lens surface generated by mixing the first liquid and the contact lens composition. Negative interaction including can be suppressed.

On the other hand, as a second embodiment relating to a method for suppressing negative interaction, in the first embodiment relating to the method for suppressing negative interaction described above, in particular, glucose, sucrose, lactose, maltose, trehalose, erythritol, Adopting a composition for contact lenses containing at least one selected from low molecular polyol compounds consisting of xylitol, maltitol, mannitol, sorbitol, to suitably suppress negative interaction with the first liquid Can do.

The present invention relating to the composition for contact lenses and the preferred embodiment of the present invention relating to the method for suppressing negative interaction have been described in detail while specifically illustrating preferred embodiments of the present invention. However, the present invention is not construed as being limited to the above specific description.

Hereinafter, the results of experiments conducted to further clarify the technical significance of the present invention relating to the composition for contact lenses and the present invention relating to a method for suppressing negative interactions will be described.

(Experimental example 1)
First, using a commercially available multipurpose liquid for contact lenses as the first liquid, an experiment for confirming the inhibitory effect of negative interaction was performed by mixing with the composition for contact lenses according to the present embodiment.

As the first liquid, Bioclen Zero (manufactured by Offtex Co., Ltd.), which is a commercially available multipurpose liquid for contact lenses, was employed. In addition, this bioclen zero contains 0.001 mg of polyhexanide hydrochloride (bactericidal agent) preparation in 1 ml. In addition, a stabilizer, a buffer, an isotonic agent, a pH adjuster, a surfactant, polylysine, Contains hypromellose, sodium hyaluronate, boric acid, polyoxyethylene polyoxypropylene glycol. On the other hand, the composition of the contact lens composition used in this experiment is as shown in Table 1 below. That is, Examples 1 to 10 contain any one of mannitol, sorbitol, glucose, trehalose, and erythritol as a low molecular polyol compound. On the other hand, Comparative Examples 1 and 2 do not contain these low molecular polyol compounds. The contact lens compositions of Examples 1 to 10 and Comparative Examples 1 and 2 and the first liquid were mixed at a volume ratio of 1: 1. After mixing, x indicates that precipitation or precipitation occurred, no precipitation or precipitation occurs, but Δ indicates that the entire solution is cloudy, and ○ indicates that neither precipitation nor precipitation or clouding was observed. It was evaluated. The results are also shown in Table 1 below.

As is clear from the results shown in Table 1, in Comparative Examples 1 and 2 using the composition for contact lenses that does not contain the low molecular polyol compound, the evaluation is x, and the low molecular polyol compound is included. It can be seen that the mixture of the first contact lens composition and the first liquid causes precipitation or precipitate formation as a negative interaction. On the other hand, in Examples 1 to 10 using the contact lens composition containing the low-molecular polyol compound, the evaluation of the precipitates is all “◯” or “Δ”, and precipitation and precipitate generation as a negative interaction Is suppressed.

In this experiment, as the polymer polyol compound, polyvinyl alcohol having a kinematic viscosity of about 5 mm ² / s when a 4% by weight aqueous solution is used and about 24 mm ² / s when a 4% by weight aqueous solution is used. Two types of polyvinyl alcohol are used. The negative interaction can be satisfactorily suppressed even when any of the two types of polyvinyl alcohols having a kinematic viscosity of about 30 mm ² / s or less when used as a 4% by weight aqueous solution is used. In addition, the value of kinematic viscosity of each polyvinyl alcohol is a manufacturer's standard value, and is measured in accordance with the viscosity measurement method of polyvinyl alcohol (partial saponification) defined by the pharmaceutical additive standard. That is, it is a numerical value measured at 20 ° C. using a Ubbelohde viscometer with a 4 wt% aqueous solution.

In addition, as described above, boric acid is blended in bioclen zero, which is a commercially available multipurpose liquid for contact lenses, and negative interactions such as precipitation and precipitation seen in Comparative Examples 1 and 2, It is presumed that the mixed contact between boric acid and polyvinyl alcohol is the main factor. In Examples 1 to 10, even when the first liquid containing boric acid and the composition for contact lenses containing polyvinyl alcohol were mixed with a low molecular polyol compound such as mannitol, negative mutual It turns out that generation | occurrence | production of an effect | action can be suppressed effectively.

(Experimental example 2)
Next, in place of the first solution used in Experimental Example 1 described above, a negative contact interaction is suppressed by using a commercially available contact lens packaging solution and contact lens ophthalmic solution (artificial tear). An experiment was conducted to confirm the effect.

The first liquid used is as shown in Table 2 below. That is, as an example of a contact lens packaging solution, a packaging solution enclosed in a package of One Day Accuview (manufactured by Johnson & Johnson Co., Ltd.), a commercially available daily disposable soft contact lens, was employed. In addition, sodium chloride and a buffer agent are mix | blended with the packaging solution of 1 day accu-view. Although the substance name of this buffering agent and other details of composition are unknown, the inventors have analyzed and found that boric acid is blended in this packaging solution. Therefore, it is guessed that the boric acid type buffering agent is used as a buffering agent. Moreover, Rohto C Cube Cool Charge α (manufactured by Rohto Pharmaceutical Co., Ltd.) was employed as an example of commercially available eye drops (artificial tears) for contact lenses. This funnel C cube cool charge α contains 0.080% potassium chloride, 0.440% sodium chloride and 0.070% hydroxyethyl cellulose. Other additives include boric acid, borax, polyoxy Ethylene polyoxypropylene glycol, polyoxyethylene hydrogenated castor oil, Na edetate, 1-menthol, and pH regulator are blended. As the composition for contact lenses, as shown in Table 2, the same compositions as in Example 8 and Comparative Example 2 used in Experimental Example 1 were used. These first liquid and contact lens composition were mixed at a volume ratio of 1: 1. After mixing, x indicates that precipitation or precipitation occurred, no precipitation or precipitation occurs, but Δ indicates that the whole solution is cloudy, and ○ indicates that neither precipitation nor precipitation or clouding was observed. It was evaluated. The evaluation results are also shown in Table 2 below.

As is clear from the results shown in Table 2, in Comparative Example 2 using the composition for contact lenses that does not contain a low-molecular polyol compound, the evaluation of any of the two types of the first liquid is x. It can be seen that the interaction between the contact lens composition containing no low molecular polyol compound and each first liquid causes a negative interaction such as precipitation and formation of a precipitate. On the other hand, in Example 8 using the composition for contact lenses containing mannitol as the low-molecular polyol compound, the evaluations are all good, and negative interactions such as the formation of precipitates and precipitates are effectively suppressed. Yes.

From this result, by blending the low molecular polyol compound in the composition for contact lenses, even if the first liquid is a packaging solution for contact lenses, and eye drops (artificial tears) for contact lenses, It can be confirmed that the generation of precipitates and precipitates, which are negative interactions, is suppressed. Both the commercially available contact lens packaging solution used in this experiment and the ophthalmic solution for contact lenses contain boric acid, and the main factors of negative interaction are boric acid and polyvinyl alcohol. It is presumed that this is a mixed contact.

(Experimental example 3)
Furthermore, an experiment to confirm the negative interaction suppression effect in a contact lens composition using a commercially available contact lens multipurpose liquid or eyewash as the first liquid and polyvinyl alcohol having a different kinematic viscosity. went.

The details of the first liquid and the contact lens composition used are as shown in Table 3 below. That is, the multipurpose liquid for contact lenses as the first liquid employs Bioclen Zero (manufactured by Off-Tex Co., Ltd.) in the same manner as in Experimental Example 1 described above, and as the eyewash, Ivon (Kobayashi Pharmaceutical Co., Ltd.) is a commercially available eyewash. Adopted). Since the composition of bioclen zero has already been described, description thereof is omitted here. On the other hand, Ivon, an eyewash, contains 0.2% epsilon aminocaproic acid, 0.01% dipotassium glycyrrhizinate, 0.003% chlorpheniramine maleate, 0.01% pyridoxine hydrochloride (vitamin B6), tocopherol 0.005% acetate ester and 0.04% sodium chondroitin sulfate are blended. Other additives include boric acid, borax, sodium edetate hydrate, polysorbate 80, l-menthol, d-Borneol and pH adjuster are blended. That is, both of these multipurpose liquids and eyewashes contain boric acid. Further, polyvinyl alcohol contained in the contact lens composition has a kinematic viscosity at 4 wt% aqueous solution, respectively 25 mm ² / s, two types is 40 mm ² / s is adopted. Examples 11 to 16 contain either mannitol or erythritol as a low molecular polyol compound. These first liquid and each contact lens composition were mixed at a volume ratio of 1: 1. As a result, the precipitate or precipitate produced x, no precipitate or precipitate was produced, but the whole solution became cloudy Δ, no precipitate or precipitate formation or clouding was observed ○ It was evaluated. The evaluation results are also shown in Table 3 below.

As is clear from the results shown in Table 3, in Comparative Examples 3 and 4 using the composition for contact lenses that does not contain the low-molecular polyol compound, the evaluation was x in any of the two types of the first liquid. Thus, it can be seen that the interaction between the contact lens composition not containing the low molecular polyol compound and each first liquid causes precipitation and precipitate formation as negative interactions. On the other hand, in Examples 11 to 16 using the composition for contact lenses containing mannitol or erythritol as the low-molecular polyol compound, the evaluation of the precipitates was either ◯ or △. Formation of precipitates is effectively suppressed.

In addition, when the results using two types of polyvinyl alcohols having different kinematic viscosities are compared with each other, in an example using polyvinyl alcohol having a kinematic viscosity of 25 mm ² / s in a 4% by weight aqueous solution, negative interaction is more reliable. Can be confirmed. Therefore, it can be seen that it is desirable to use polyvinyl alcohol having a kinematic viscosity of about 30 mm ² / s or less when a 4 wt% aqueous solution is used as the polymer polyol compound used in the present embodiment. In addition, it can also confirm that a negative interaction can be easily suppressed as the concentration of polyvinyl alcohol decreases, and a negative interaction tends to occur as the concentration increases.

(Experimental example 4)
As a first solution, an experiment was conducted to confirm the negative interaction suppression effect using a commercially available contact lens mounting solution containing polyvinyl alcohol and a contact lens composition containing boric acid. .

Details of the first liquid and the contact lens composition used are as shown in Table 4 below. That is, Smile Contact Fine Fit (manufactured by Lion Corporation), which is a commercially available mounting liquid, was employed as the mounting liquid for contact lenses as the first liquid. For Smile Contact Finefit, hydroxylpropyl methylcellulose 2910 1.0%, potassium L-aspartate 0.1%, aminoethylsulfonic acid 1.0%, sodium chloride 0.6%, polyvinyl alcohol (partially saponified product) ) 2.0%, and other additives include Na edetate, cyclodextrin, benzalkonium chloride, and a pH adjuster. That is, this mounting solution contains polyvinyl alcohol but does not contain boric acid. Moreover, the composition for contact lenses was made into the composition which does not contain polyvinyl alcohol, while both an Example and a comparative example contain boric acid. Furthermore, in Example 17, mannitol was blended as a low molecular polyol compound. These first liquid and contact lens composition were mixed at a volume ratio of 1: 1, respectively, and x and a precipitate or precipitate were produced. The white turbid one was evaluated as Δ, and the one in which neither precipitation nor precipitation generation nor white turbidity was observed was evaluated as ◯. The results are shown in Table 4 below.

As is clear from the results shown in Table 4, in Comparative Example 5 using the composition for contact lenses that does not contain a low molecular polyol compound, the evaluation is x, and the first liquid containing polyvinyl alcohol, It can be seen that mixing with a composition for contact lenses containing boric acid results in the formation of a precipitate that is a negative interaction. On the other hand, in Example 17 using the composition for contact lenses containing mannitol as the low-molecular-weight polyol compound, the evaluation is ○, and the negative interaction generated in Comparative Example 5 is effectively suppressed. . That is, even when the first liquid contains polyvinyl alcohol and the contact lens composition contains boric acid, the contact lens composition contains a low-molecular polyol compound, thereby causing a negative interaction. It can be confirmed that it can be suppressed.

(Experimental example 5)
Using a commercially available multi-purpose liquid for contact lenses as a first liquid, an experiment was conducted in which the kinematic viscosity was confirmed by mixing with a composition for contact lenses using polyvinyl alcohol having different kinematic viscosities.

The details of the first liquid and the contact lens composition used are as shown in Table 5 below. That is, as the first-purpose multi-purpose liquid for contact lenses, Bioclen Zero (manufactured by Offtex Co., Ltd.), which is a commercially available multi-purpose liquid, was employed. Further, polyvinyl alcohol contained in the contact lens composition has a kinematic viscosity at 4 wt% aqueous solution was 5 mm ² / s, respectively, 25 mm ² / s, the three is 40 mm ² / s is adopted. The first liquid and these contact lens compositions were mixed at a volume ratio of 1: 1. And the kinematic viscosity at 20 degreeC of the solution after mixing was measured using the Ubbelohde viscometer (made by Shibata Kagaku Co., Ltd.).

As is apparent from the results shown in Table 5, when Examples 18 to 21 in which the low molecular polyol compound was blended with Comparative Examples 6 to 8 in which the low molecular polyol compound was not blended, a 4% by weight aqueous solution kinematic viscosity ^{^{5mm 2 / s, 25mm 2 /}} s, in either embodiment using a polyvinyl alcohol 40 mm ² / s, kinematic viscosity is higher than comparative example using the same polyvinyl alcohol in. That is, in Comparative Examples 6 to 8, the viscosity decrease as a negative interaction occurs, while in Examples 18 to 21, the decrease in viscosity is suppressed and the kinematic viscosity can be maintained at a high value. That is, in Examples 18 to 21, it can be confirmed that the low molecular polyol compound is compounded to suppress a decrease in viscosity as a negative interaction.

On the other hand, when comparing the results with different polyvinylalcohol having a kinematic viscosity from each other, the kinematic viscosity at 4 wt% aqueous solution 5 mm ² / s, Examples 18 to 20 using the polyvinyl alcohol 25 mm ² / s, kinematic viscosity This value is particularly high, and it can be seen that the decrease in viscosity can be suppressed particularly well. Therefore, it can be confirmed that it is particularly desirable to use polyvinyl alcohol having a kinematic viscosity of 30 mm ² / s or less in a 4% by weight aqueous solution in order to suppress a decrease in viscosity, which is a negative interaction. It should be noted that, as confirmed in Experimental Example 3 (Examples 14 to 16), even if the polyvinyl alcohol has a kinematic viscosity greater than 30 mm ² / s, the effect of suppressing the formation of precipitation can be sufficiently exerted. .

(Experimental example 6)
Using a commercially available multipurpose liquid for contact lenses as the first liquid, it was mixed with the composition for contact lenses according to the present embodiment, and an experiment for confirming the effect of improving wettability was conducted.

As the first liquid, Bioclen Zero (manufactured by Offtex Co., Ltd.), which is a commercially available multipurpose liquid for contact lenses, is employed, which is a contact lens composition having the composition shown in Table 6 below and a volume ratio of 1: 1. The ratio was mixed. After immersing a test lens (Menicon Co., Ltd., Menicon 2 Week Premio) for 4 hours in this mixed solution, the lens was taken out and the liquid adhering to the lens surface was gently wiped off. Thereafter, physiological saline was dropped on the lens front curve surface, and the contact angle of the lens surface with respect to the physiological saline was measured. Then, with respect to the contact angles of the actually measured samples, the average value obtained by measuring twice in Comparative Example 10 was used as a reference value, and the wettability improvement rate was calculated by the following calculation formula. In addition, as Table 6 shows, the comparative example 10 does not contain polyvinyl alcohol, and it is set as the negative interaction by mixing with the boric acid contained in bioclen zero does not arise. Moreover, since the wettability increases as the contact angle decreases, when the obtained wettability improvement rate is positive, it means that the wettability is higher than when the comparative example 10 as a control is used.
Wettability improvement rate (%) = {1− (actual value of contact angle) / (average contact angle in Comparative Example 10)} × 100

As is clear from the results shown in Table 6, in Comparative Example 9 using the composition for contact lenses that contains polyvinyl alcohol but does not contain a low molecular polyol compound, the wettability improvement rate is negative. It can be seen that mixing with the composition for contact lenses with one liquid causes a decrease in wettability, which is a negative interaction. On the other hand, in Examples 22 to 25 using the contact lens composition containing either mannitol or erythritol as the low molecular polyol compound, the wettability improvement rate is positive. In particular, in Examples 24 and 25 containing polyvinyl alcohol, the wettability improvement rate is positive, and it is understood that the decrease in wettability is suppressed. In addition, the wettability improvement rates of Examples 24 and 25 in which these polyvinyl alcohols and low molecular polyol compounds are combined are higher than those in Examples 22 and 23 in which only the low molecular polyol compounds are combined. . That is, in Examples 24 and 25, a synergistic effect was produced by combining polyvinyl alcohol and a low molecular polyol compound, and Examples 22 and 23 in which only a low molecular polyol compound was blended without including polyvinyl alcohol were obtained. The wettability is dramatically improved as compared with Comparative Example 9 in which only No is added. From this result, according to the present embodiment, if a composition for contact lenses containing a combination of polyvinyl alcohol and a low molecular weight polyol compound is used, not only the negative interaction can be suppressed well, but also the wettability of the contact lens is greatly enhanced. I understand that I can do it.

Claims

Select from at least one of contact lens multipurpose solution, bactericidal solution, cleaning solution, protein cleaning / removing agent, preservative solution, rinsing solution, eye drop solution, eye wash solution, mounting solution, packaging solution, hydrating solution, tear solution A contact lens composition that is mixedly contacted with the first liquid that contacts the contact lens,
At least one negative interaction among the generation of precipitates, the formation of precipitates, gelation, reduction in viscosity, and reduction in water wettability of the contact lens surface, which occurs due to mixed contact with the first liquid, is suppressed. A composition for contact lenses.
The contact lens composition according to claim 1, comprising a low-molecular polyol compound.
The contact lens according to claim 2, wherein the low molecular polyol compound contains at least one selected from glucose, sucrose, lactose, maltose, trehalose, erythritol, xylitol, maltitol, mannitol, and sorbitol. Composition.
The contact lens composition according to any one of claims 1 to 3, further comprising a polymer polyol compound.
The composition for a contact lens according to claim 4, wherein the polymer polyol compound is polyvinyl alcohol having a kinematic viscosity of 30 mm 2 / s or less in a 4 wt% aqueous solution.
Select from at least one of contact lens multipurpose solution, bactericidal solution, cleaning solution, protein cleaning / removing agent, preservative solution, rinsing solution, eye drop solution, eye wash solution, mounting solution, packaging solution, hydrating solution, tear solution A method of suppressing negative interaction generated by mixing and contacting the contact lens composition with the first liquid that contacts the contact lens,
The contact lens composition according to any one of claims 1 to 5 is used as the contact lens composition, and a precipitate is generated as the negative interaction by mixing and contacting the first liquid. A method for suppressing a negative interaction characterized by suppressing at least one of precipitate formation, gelation, viscosity reduction, and water wettability reduction of a contact lens surface.