JP2005187345A - Contact lens-mounting liquid - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a contact lens-mounting liquid which can improve a contact lens-mounting touch and can improve the deterioration of visibility, after used. <P>SOLUTION: This contact lens-mounting liquid is characterized by containing a polyvinyl polymer, a cellulosic polymer, and 0.6 to 5 W/V % of glycerol. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a contact lens mounting liquid, and more particularly to a contact lens mounting liquid that improves the wearing feeling of a contact lens and blurring of the visual field after use.

  Wearing a contact lens makes it easy to feel dryness and foreign matter when wearing the contact lens because foreign matter is inserted into the eye. In order to solve these problems, contact lens mounting liquids that incorporate various water-soluble polymer compounds and the like, increase the viscosity of the composition, and improve dry feeling and foreign object feeling have been proposed (for example, Patent Documents 1 to 7). reference).

  However, such a contact lens mounting liquid contains many polymer compounds and has a high viscosity, so that the liquid is not easily discharged from the eye. For this reason, the field of view is often blurred after the contact lens is mounted, and the usability is not satisfactory.

  Therefore, there has been a demand for a contact lens mounting solution that not only has an excellent feeling of use when a contact lens is mounted, but also suppresses blurring of the field of view after use.

JP 2001-125052 JP 2001-187731 A JP 2001-187733 A JP 2001-318348 A JP 2001-318350 A JP 2002-322048 A JP 2003-66383 A

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a contact lens mounting liquid that can improve the wearing feeling of a contact lens and can improve blurring of the visual field after use.

  As a result of intensive studies to achieve the above object, the present inventor solved the above problem by further adding a specific amount of glycerin to a contact lens mounting liquid comprising a polyvinyl polymer compound and a cellulose polymer compound. It has been found that this can be done, and the present invention has been made.

Therefore, the present invention provides [1]. A contact lens mounting liquid comprising a polyvinyl polymer compound, a cellulose polymer compound, and glycerin 0.6 to 5 W / V%,
[2]. The contact lens mounting liquid according to [1], wherein the cellulosic polymer compound has a weight average molecular weight of 6 to 110,000.

  ADVANTAGE OF THE INVENTION According to this invention, the contact lens mounting liquid which can improve the wearing feeling of a contact lens and the blur of the visual field after use can be provided.

Hereinafter, the present invention will be described in more detail.
The polyvinyl polymer compound of the present invention is not particularly limited as long as it is usually used for ophthalmology. For example, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, polyvinyl methyl ether and the like can be mentioned. These can be used individually by 1 type or in combination of 2 or more types. Among these, polyvinyl alcohol and polyvinyl pyrrolidone are preferable.

  The weight average molecular weight of the polyvinyl polymer compound is not particularly limited, but is preferably 2 to 1,000,000. If the weight average molecular weight is too small, the improvement of the feeling of foreign matter after wearing may be insufficient, and if it is too large, the effect of preventing glycerin from blurring may not be sufficiently exhibited. The weight average molecular weight is a value obtained by liquid chromatography using a GPC column.

  The cellulose polymer compound of the present invention is not particularly limited, and examples thereof include hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxymethylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxyethylmethylcellulose, carboxymethylcellulose and the like. These can be used individually by 1 type or in combination of 2 or more types. Of these, hydroxypropylmethylcellulose and methylcellulose are particularly preferred.

  The cellulosic polymer compound preferably has a weight average molecular weight of 6 to 110,000. If the weight average molecular weight is less than 60,000, the improvement of the feeling of foreign matter after wearing may be insufficient, and if it exceeds 110,000, the effect of preventing glycerin from blurring may not be sufficiently exhibited. In the present invention, the weight average molecular weight is obtained by liquid chromatography using a GPC column.

  The content of the polyvinyl polymer compound and the cellulose polymer compound is 0. 1 to 5 W / V (mass / capacity, the same applies hereinafter)% is preferable, the lower limit is preferably 0.3 W / V% or more, and the upper limit is preferably 3 W / V% or less. If the content is less than 0.1 W / V%, the improvement of the foreign matter feeling after mounting may be insufficient, and if it exceeds 5 W / V%, the stickiness may be deteriorated and the usability may be deteriorated.

  The present invention uses a combination of a polyvinyl polymer compound and a cellulose polymer compound from the viewpoint of improving the feeling of foreign matter and dryness after mounting. In this case, the content ratio between the polyvinyl polymer compound and the cellulose polymer compound is preferably 1:10 to 20: 1.

  In the present invention, by adding a specific amount of glycerin to a contact lens mounting liquid composed of a polyvinyl polymer compound and a cellulose polymer compound, it is possible to achieve both improvement of wearing feeling and blurring of vision. .

  The content of glycerin is 0.6 to 5 W / V%, the lower limit is preferably 1 W / V% or more, and the upper limit is preferably 3 W / V% or less. If it is less than 0.6 W / V%, the effect of improving blurring after mounting is not sufficient. On the other hand, if it exceeds 5 W / V%, the effect of improving blurring after mounting is not sufficient, and stickiness after mounting.

  The viscosity of the contact lens mounting liquid is not particularly limited, but is usually 5 to 100 mPa · s, preferably 10 to 50 mPa · s, as measured by an E-type rotational viscometer at 20 ° C. If it is less than 5 mPa · s, the fit after installation may not be sufficient, and if it exceeds 100 mPa · s, it may become sticky after installation. The viscosity is a value measured at 20 rpm if it is less than 30 mPa · s, and 5 rpm if it is 30 mPa · s or more.

  In the mounting liquid of the present invention, various components used in the ophthalmic composition can be blended, if necessary, within a range that does not impair the effects of the present invention. Examples of preferable ingredients include drugs, pH adjusters, buffers, stabilizers, isotonic agents, solubilizers, antioxidants, preservatives, and refreshing agents. In this invention, each agent can be used individually by 1 type or in combination of 2 or more types.

Examples of the drug include anti-inflammatory agents such as dipotassium glycyrrhizinate, allantoin, berberine chloride, berberine sulfate, sodium azulene sulfonate, zinc sulfate, zinc lactate, lysozyme chloride, flavin adenine dinucleotide sodium (active vitamin B ₂ ), cyanocobalamin (vitamin B _12), pyridoxine hydrochloride (vitamin B _6), vitamin E acetate, panthenol, calcium pantothenate, sodium pantothenate, vitamins such as retinol acetate, retinol palmitate (vitamin a palmitate), L-aspartic acid Potassium, magnesium L-aspartate, potassium magnesium L-aspartate (mixture of equal amounts), aminoethylsulfonic acid (taurine), epsilon aminocaproic acid, L-glutamic acid, L -Amino acids such as sodium glutamate, antihistamines such as diphenhydramine hydrochloride and chlorpheniramine maleate, epinephrine, epinephrine hydrochloride, ephedrine, naphazoline hydrochloride, naphazoline nitrate, phenylephrine hydrochloride, tetrahydrozoline hydrochloride, chondroitin sulfate, etc. Corneal protective components such as mucopolysaccharides, sulfamethoxazole, sulfamethoxazole sodium, sulfaxazole, sulfisoxidine sodium and other sulfa drugs, cromoglycic acid, cromoglycate sodium, tranilast and other antiallergic agents Is mentioned. In particular, from the viewpoint of suppressing eye fatigue and inflammation caused by wearing soft contact lenses, it is preferable to contain a corneal protective component such as vitamins or derivatives thereof, amino acids or salts thereof, anti-inflammatory agents, mucopolysaccharides and the like.

  The effective content of each drug can be selected as the content of each drug, but in the range of 0.001 to 3 W / V% in the wearing solution in terms of eye irritation, composition stability, and the like. Preferably there is.

  Examples of the pH adjuster include citric acid, sodium citrate, boric acid, borax, phosphoric acid, sodium hydrogen phosphate, sodium dihydrogen phosphate, glacial acetic acid, trometamol, sodium hydrogen carbonate, sodium hydroxide, potassium hydroxide. , Triethanolamine, diethanolamine, monoethanolamine, hydrochloric acid, sulfuric acid and the like. Citric acid, sodium citrate, boric acid, borax, phosphoric acid, sodium hydrogen phosphate, sodium dihydrogen phosphate, tartaric acid, sodium tartrate, gluconic acid, sodium gluconate, acetic acid, acetic acid, preferably also acting as a buffer Sodium, trometamol, sodium hydrogen carbonate, various amino acids, or combinations thereof are preferably used.

  The pH of the contact lens mounting solution is preferably adjusted to be maintained at 4-8. Moreover, it is preferable that content of a buffering agent is the range of 0.001-2% W / V in mounting | wearing liquid.

  Examples of the stabilizer include sodium edetate, edetic acid, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin and the like. Edetic acids have the effect of maintaining the stability of the system due to their chelating effect, and cyclodextrins have the effect of suppressing the adsorption of components (such as benzalkonium chloride) that are easily adsorbed to soft contact lenses. The content of the stabilizer is preferably in the range of 0.001 to 2 W / V% in the mounting liquid.

  Examples of the isotonic agent include potassium chloride, sodium chloride, calcium chloride, magnesium sulfate, mannitol and the like. The content of the tonicity agent is preferably in the range of 0.05 to 1 W / V% in the mounting solution. A preferable osmotic pressure as a mounting liquid is 150 to 500 mOsm, and in particular, the contact lens mounting liquid of the present invention is preferably adjusted to a range of 250 to 370 mOsm.

  Examples of solubilizing agents include propylene glycol, polyethylene glycol, proxamers, POE sorbitan fatty acid esters such as POE (20) sorbitan monooleate, and surfactants such as POE hydrogenated castor oil such as POE (60) hydrogenated castor oil. Can be mentioned. Preferred solubilizers are propylene glycol, polyethylene glycol and polysorbate 80. The content of the solubilizing agent is preferably in the range of 0.001 to 2 W / V% in the mounting liquid.

Examples of the antioxidant include dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroquinone, propyl gallate, sodium bisulfite and the like. The content of the antioxidant is preferably in the range of 0.001 to 1% in the mounting liquid.
Examples of the preservative include benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, sorbic acid, potassium sorbate, chlorobutanol, and paraoxybenzoic acid ester. The content of the preservative is preferably in the range of 0.001 to 0.5 W / V% in the mounting liquid.

  Examples of the refreshing agent include camphor and cool mint no. 71212, Geraniol, peppermint water, peppermint oil, menthol, borneol, eucalyptus oil, fennel oil, bergamot oil, linalool, N-ethyl-p-menthane-carboxamide (for example, WS-3, manufactured by Takasago International Corporation), etc. Is mentioned. The content of the refreshing agent is preferably in the range of 0.0001 to 0.1 W / V% in the mounting liquid.

  The contact lens mounting liquid of the present invention can be produced by a known production method with the balance being water. For example, after dissolving the above components in sterilized purified water, water such as ion-exchanged water, or a mixed solvent with an alcohol such as ethanol, etc., the pH and, if necessary, the osmotic pressure, etc., are made pH adjusting agent, isotonic. By appropriately adjusting with the agent, a contact lens mounting liquid can be obtained.

  The obtained contact lens mounting liquid is filled in a known eye drop container (containing an ultraviolet ray prevention agent or a dye is preferable for the stability of the contents), and is subjected to packaging such as film packaging, so that the storage stability is good. Can be provided as a contact lens mounting solution.

  The type of contact lens to which the contact lens mounting liquid of the present invention can be applied is not particularly limited, and is a hard contact lens, an oxygen-permeable hard contact lens, a soft contact lens, a one-day disposable contact lens, a one-week disposable contact. It can be applied to both lenses and 2 weeks disposable contact lenses.

  The method of use is not particularly limited, but the method of applying or directly dripping the mounting solution onto the contact lens, the method of immersing the contact lens in the mounting solution, or adding the mounting solution to the storage solution in which the contact lens is stored, And the like.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

[Examples 1-33, Comparative Examples 1-3]
After dissolving each compounding component in the table in sterilized purified water according to a standard method so as to have the composition of Tables 1 to 5 (compounding unit, g / 100 mL, W / V%), each solution is aseptically filtered. A contact lens mounting solution was prepared. The following evaluation was performed about the obtained mounting | wearing liquid. The results are also shown in Tables 1-5.

Evaluation Method A contact lens user (5 soft contact lens users and 5 oxygen permeable hard contact lenses) was used as a panelist. Each paneler applied 3 drops of contact lens mounting solution to each contact lens, and evaluated the blur of field of view after mounting and the feeling of use during mounting based on the following evaluation criteria.

<Evaluation criteria for blurred vision>
5: After wearing, blurring of field of vision disappears within 1 minute 4: After wearing, blurred for 1 minute to less than 1 minute and 30 seconds 3: After wearing, blurred for 1 minute and 30 seconds to less than 2 minutes 2: After wearing, 2 minutes ~ Blurred for less than 2 minutes and 30 seconds 1: Blurred for more than 2 minutes and 30 seconds after wearing In the table, ◎ for those with an average paneler value of 4 or more, ○ for those with an average value of 3 or more and less than 4 Visibility evaluation of visual field is shown as Δ for those less than 3, and x for those less than 2.

<Evaluation during use>
5: Discomfort such as foreign body feeling and dryness is greatly improved compared to the case where no mounting liquid is used 4: Discomfort such as foreign body feeling and dryness is improved compared to the case where no mounting liquid is used 3: Wearing liquid Discomfort such as foreign body feeling or dryness is slightly improved compared to the case where no use is used 2: Discomfort such as foreign object feeling or dryness is not changed compared to the case where no mounting liquid is used 1: When mounting liquid is not used In the table, the feeling of discomfort such as a foreign body feeling or dryness is felt. In the table, the average value of the panel is 4 or more, ◯ is 3 or more and less than 4, and is 2 or more and less than 3. An evaluation of the feeling of use is shown by Δ for those having less than 2 and x for those having less than 2. The contact lens mounting liquid is preferably ◯ or more, more preferably ◎.

The components described in the table are shown below.
PVA Gohsenol EG-05: Polyvinyl alcohol, Nippon Synthetic Chemical Industry Co., Ltd. HPMC 60SH-50: Hydroxypropylmethylcellulose Metroles 60SH-50 (weight average molecular weight 100,000), Shin-Etsu Chemical Co., Ltd. HPMC 60SH-4000: Hydroxy Propylmethylcellulose Metrose 60SH-4000 (weight average molecular weight 350,000), MC SM-15 manufactured by Shin-Etsu Chemical Co., Ltd .: Methylcellulose Metrose SM-15, PVP Kollidon 25 manufactured by Shin-Etsu Chemical Co., Ltd .: Polyvinylpyrrolidone, BASF (stock) ) PVP Kollidon 30: Polyvinylpyrrolidone, manufactured by BASF Corporation

Claims (2)

  A contact lens mounting liquid comprising a polyvinyl polymer compound, a cellulose polymer compound, and glycerin 0.6 to 5 W / V%. The contact lens mounting liquid according to claim 1, wherein the weight-average molecular weight of the cellulosic polymer compound is 6 to 110,000.