WO2011059148A1 - 흡연 독성 해독용 조성물 - Google Patents
흡연 독성 해독용 조성물 Download PDFInfo
- Publication number
- WO2011059148A1 WO2011059148A1 PCT/KR2010/002456 KR2010002456W WO2011059148A1 WO 2011059148 A1 WO2011059148 A1 WO 2011059148A1 KR 2010002456 W KR2010002456 W KR 2010002456W WO 2011059148 A1 WO2011059148 A1 WO 2011059148A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- extract
- powder
- composition
- toxicity
- smoking
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 71
- 231100000419 toxicity Toxicity 0.000 title claims abstract description 42
- 230000001988 toxicity Effects 0.000 title claims abstract description 42
- 230000000391 smoking effect Effects 0.000 title claims abstract description 38
- 239000000284 extract Substances 0.000 claims abstract description 144
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims abstract description 28
- 240000003768 Solanum lycopersicum Species 0.000 claims abstract description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 49
- 239000000843 powder Substances 0.000 claims description 40
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 18
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- 241000219495 Betulaceae Species 0.000 claims description 13
- YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 claims description 13
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 12
- 238000001784 detoxification Methods 0.000 claims description 12
- 239000012046 mixed solvent Substances 0.000 claims description 12
- 244000019194 Sorbus aucuparia Species 0.000 claims description 11
- 235000006414 serbal de cazadores Nutrition 0.000 claims description 11
- 244000061176 Nicotiana tabacum Species 0.000 claims description 10
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 10
- 235000013305 food Nutrition 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 235000013361 beverage Nutrition 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 8
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 231100000614 poison Toxicity 0.000 claims description 4
- 231100000331 toxic Toxicity 0.000 claims description 4
- 230000002588 toxic effect Effects 0.000 claims description 4
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 3
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 3
- 244000269722 Thea sinensis Species 0.000 claims description 3
- 235000011399 aloe vera Nutrition 0.000 claims description 3
- 235000009569 green tea Nutrition 0.000 claims description 3
- 229940010454 licorice Drugs 0.000 claims description 3
- 244000291564 Allium cepa Species 0.000 claims description 2
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims description 2
- 241001116389 Aloe Species 0.000 claims description 2
- 241001061264 Astragalus Species 0.000 claims description 2
- 241001107116 Castanospermum australe Species 0.000 claims description 2
- 241000675108 Citrus tangerina Species 0.000 claims description 2
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 2
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 2
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 2
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 2
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 2
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 2
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 2
- 240000000171 Crataegus monogyna Species 0.000 claims description 2
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 2
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 2
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 claims description 2
- 235000003805 Musa ABB Group Nutrition 0.000 claims description 2
- 235000015266 Plantago major Nutrition 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 2
- 244000223014 Syzygium aromaticum Species 0.000 claims description 2
- 235000019714 Triticale Nutrition 0.000 claims description 2
- 235000006533 astragalus Nutrition 0.000 claims description 2
- 235000021279 black bean Nutrition 0.000 claims description 2
- 230000007812 deficiency Effects 0.000 claims description 2
- 210000004207 dermis Anatomy 0.000 claims description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052737 gold Inorganic materials 0.000 claims description 2
- 239000010931 gold Substances 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims description 2
- 239000008274 jelly Substances 0.000 claims description 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims description 2
- 239000010865 sewage Substances 0.000 claims description 2
- 210000004233 talus Anatomy 0.000 claims description 2
- YEFOAORQXAOVJQ-UHFFFAOYSA-N wuweizischun A Natural products C1C(C)C(C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-UHFFFAOYSA-N 0.000 claims description 2
- 241000228158 x Triticosecale Species 0.000 claims description 2
- 244000046052 Phaseolus vulgaris Species 0.000 claims 2
- 240000008790 Musa x paradisiaca Species 0.000 claims 1
- 239000011121 hardwood Substances 0.000 claims 1
- 239000002574 poison Substances 0.000 claims 1
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract description 32
- 229960002715 nicotine Drugs 0.000 abstract description 32
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract description 32
- 230000000694 effects Effects 0.000 abstract description 24
- 240000001659 Oldenlandia diffusa Species 0.000 abstract description 2
- 240000000643 Alnus japonica Species 0.000 abstract 1
- 235000004489 Sorbus commixta Nutrition 0.000 abstract 1
- 241001115347 Sorbus commixta Species 0.000 abstract 1
- 238000000605 extraction Methods 0.000 description 19
- 238000002474 experimental method Methods 0.000 description 16
- 239000007787 solid Substances 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 9
- 239000000796 flavoring agent Substances 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000003755 preservative agent Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 239000003995 emulsifying agent Substances 0.000 description 4
- -1 etc.) Polymers 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 235000013355 food flavoring agent Nutrition 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 238000009533 lab test Methods 0.000 description 4
- 229930014626 natural product Natural products 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- UIKROCXWUNQSPJ-VIFPVBQESA-N (-)-cotinine Chemical compound C1CC(=O)N(C)[C@@H]1C1=CC=CN=C1 UIKROCXWUNQSPJ-VIFPVBQESA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- UIKROCXWUNQSPJ-UHFFFAOYSA-N Cotinine Natural products C1CC(=O)N(C)C1C1=CC=CN=C1 UIKROCXWUNQSPJ-UHFFFAOYSA-N 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 206010028813 Nausea Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 229950006073 cotinine Drugs 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000008693 nausea Effects 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 239000004283 Sodium sorbate Substances 0.000 description 2
- 241001092391 Sorbus Species 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 231100000357 carcinogen Toxicity 0.000 description 2
- 239000003183 carcinogenic agent Substances 0.000 description 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
- 235000005487 catechin Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000008345 mountainash Nutrition 0.000 description 2
- UMFJAHHVKNCGLG-UHFFFAOYSA-N n-Nitrosodimethylamine Chemical compound CN(C)N=O UMFJAHHVKNCGLG-UHFFFAOYSA-N 0.000 description 2
- OSECUOLAVDXRCI-UHFFFAOYSA-N n-methyl-n-(4-oxo-4-pyridin-3-ylbutyl)nitrous amide;nitrous amide Chemical group NN=O.O=NN(C)CCCC(=O)C1=CC=CN=C1 OSECUOLAVDXRCI-UHFFFAOYSA-N 0.000 description 2
- 235000021096 natural sweeteners Nutrition 0.000 description 2
- 235000011007 phosphoric acid Nutrition 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 239000000779 smoke Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 2
- 235000019250 sodium sorbate Nutrition 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- XMOCLSLCDHWDHP-SWLSCSKDSA-N (+)-Epigallocatechin Natural products C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-SWLSCSKDSA-N 0.000 description 1
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 description 1
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- HGUFODBRKLSHSI-UHFFFAOYSA-N 2,3,7,8-tetrachloro-dibenzo-p-dioxin Chemical compound O1C2=CC(Cl)=C(Cl)C=C2OC2=C1C=C(Cl)C(Cl)=C2 HGUFODBRKLSHSI-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- FMMWHPNWAFZXNH-UHFFFAOYSA-N Benz[a]pyrene Chemical compound C1=C2C3=CC=CC=C3C=C(C=C3)C2=C2C3=CC=CC2=C1 FMMWHPNWAFZXNH-UHFFFAOYSA-N 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 241001071917 Lithospermum Species 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 244000070406 Malus silvestris Species 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 208000003445 Mouth Neoplasms Diseases 0.000 description 1
- 240000005561 Musa balbisiana Species 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 235000008422 Schisandra chinensis Nutrition 0.000 description 1
- 240000006079 Schisandra chinensis Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 241000238371 Sepiidae Species 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 244000040738 Sesamum orientale Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 206010043515 Throat cancer Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000538 analytical sample Substances 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 208000007474 aortic aneurysm Diseases 0.000 description 1
- 235000021016 apples Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000004301 calcium benzoate Substances 0.000 description 1
- 235000010237 calcium benzoate Nutrition 0.000 description 1
- HZQXCUSDXIKLGS-UHFFFAOYSA-L calcium;dibenzoate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 HZQXCUSDXIKLGS-UHFFFAOYSA-L 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 231100000481 chemical toxicant Toxicity 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005584 early death Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 description 1
- 235000012734 epicatechin Nutrition 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229940107702 grapefruit seed extract Drugs 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000014666 liquid concentrate Nutrition 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000004300 potassium benzoate Substances 0.000 description 1
- 235000010235 potassium benzoate Nutrition 0.000 description 1
- 229940103091 potassium benzoate Drugs 0.000 description 1
- GKKCIDNWFBPDBW-UHFFFAOYSA-M potassium cyanate Chemical compound [K]OC#N GKKCIDNWFBPDBW-UHFFFAOYSA-M 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000004296 sodium metabisulphite Substances 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 235000021012 strawberries Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
Definitions
- the present invention relates to a composition for smoking toxicity detoxification. Specifically, it relates to a composition for smoking toxicity detox using tomato outpost extract.
- the main diseases caused by smoking include lung cancer, chronic obstructive pulmonary disease (COPD), coronary artery disease, stroke (cerebrovascular disease), heart attack, aortic aneurysm, circulatory disease (peripheral vascular disease, etc.), throat cancer, and oral cancer.
- COPD chronic obstructive pulmonary disease
- coronary artery disease stroke (cerebrovascular disease)
- stroke cerebrovascular disease
- heart attack CAD
- aortic aneurysm aortic aneurysm
- circulatory disease peripheral vascular disease, etc.
- throat cancer aortic aneurysm
- Tobacco smoke contains 4,000 species of toxic substances, including carcinogens, which are harmful to the human body, and the main harmful components are tar and nicotine, which are mixtures of various toxic substances.
- Tar contains more than 2,000 types of toxic substances, of which 20 are known to be carcinogens, including dioxin, benzopyrene and dimethylnitrosamine (Shindongcheon, Toxic Chemicals in Tobacco Smoke, Published by Korea Non-Smoking Association.
- Nicotine is nitrosamine-4- (methyl nitrosamino) -1- (3-pyridyl) -1-butanone (nitrosamine-4 (methyl nitrosamino) -1- (3-pyridyl) -1-butanone ⁇
- acute inhalation of nicotine causes symptoms such as pupil contraction, blurred vision, vomiting, difficulty breathing, increased secretions from saliva and respiratory tract, and decreased heart rate.
- Chronic atherosclerosis and hypertension Causes circulatory diseases (Brunneman, KD et al., J. Natl. Cancer Inst. 89: 868-73 (1996); Carmella, SG et al., Cancer Epidemiol Biomarkers Prev. 6: 113-20 (1997); Wynder, EL et al., Environ Health Perspect. 103 Suppl 8: 143-148 (1995).
- Green tea extract (Chung. FL Proc. Soc. Exp. Viol. Med. 220: 244-248 (1999); Fujiki, H. et al.) Is a substance that can alleviate and detoxify the toxicity of smoking by tar and nicotine. , Mutat. Res. 18: 307-310 (1998)), a mixture of a mixture extract (Korean Patent No. 0494223), Schisandra chinensis extract, Gilkyung extract, such as Eoseongcho, Pogongyoung, Licorice (Korea Patent Publication No. 2004-0102690) etc. can be mentioned.
- the present invention also discloses a technique that can alleviate and detoxify the smoking toxicity caused by tar and nicotine using tomato starch extract and the like.
- An object of the present invention is to provide a composition for smoking toxicity detoxification.
- the present invention has been completed based on the experimental results, the present invention can be understood as a composition for smoking toxicity detoxification.
- Smoking toxicity detoxification composition of the present invention is characterized in that it comprises at least one extract of tomato outpost extract, baekryeoksacho extract, rowan extract, branch extract and alder extract as an active ingredient.
- smoking toxicity refers to the toxicity caused by nicotine and / or tar, and thus smoking toxicity may be understood to have the same meaning as nicotine toxicity and / or tar toxicity.
- active ingredient means a component that can exhibit the desired activity alone or in combination with a carrier that is not active itself.
- tomato starch extract refers to tomato leaves, stems, flowers, roots or mixtures thereof regardless of the extraction method, methanol, ethanol, acetone, ethyl acetate, saturated normal butanol, chloroform, methylene chloride, water Or an extract obtained by extraction with a mixed solvent thereof and an extract fractionated with the solvents listed above in the extract.
- the extraction method may be any method such as cooling, refluxing, heating, and ultrasonic wave. It should be understood that it can.
- the "tomato outpost extract” is preferably obtained by extracting tomato leaves, stems, flowers, roots or mixtures thereof to be extracted with water, ethanol or a mixed solvent thereof, and the concentrated liquid extract from which the extraction solvent is removed. Or a solid extract.
- Oldenlandia diffusa extract may be defined the same as the “tomato outpost” except that the extraction target is the baekhwasa leaf, stem, flowers, roots or mixtures thereof. .
- Lithospermum erythrorhizon extract may be defined in the same manner as the “tomato extract” except that the extraction subject is a branched leaf, stem, flower, root or a mixture thereof.
- the mountain ash extract may be defined in the same way as the “tomato outpost” except that the extraction target is the mountain ash leaf, stem, flower, root or mixture thereof, and the “duckwood extract” is similarly Except for extracting the alder leaves, stems, flowers, roots or a mixture thereof may be defined the same as the "tomato outpost”.
- the composition for smoking toxicity detoxification of the present invention may contain any amount (effective amount) according to the purpose, formulation, compounding purpose, etc., as long as it can exhibit the detoxification activity of tomato toxic extract, such as an effective ingredient, the conventional An effective amount of phosphorus will be determined within the range of 0.001% to 99.900% by weight based on the total weight of the composition.
- An “effective amount” herein refers to an amount of active ingredient that can lead to the prevention, amelioration, treatment of smoking toxicity, or a delay in the manifestation of such toxicity. Such effective amounts can be determined experimentally within the range of ordinary skill in the art.
- Smoking toxicity detoxification composition of the present invention in addition to containing the active ingredient tomato starch extract, etc., may include a known natural product or compound known to have smoking toxicity detoxification activity to increase and enhance smoking toxicity detoxification.
- Such natural products or compounds include green tea powder or extract, black bean powder or extract, pogongyoung powder or extract, gold and silver powder or extract, triticale powder or extract, deficiency powder or extract, licorice powder or extract, hawthorn powder or extract , Herbal powder or extract, sesame powder or extract, sewage powder or extract, whole lake powder or extract, cloves powder or extract, dermis (peel of tangerine) powder or extract, moth powder or extract, plantain powder or extract, aloe powder or extract , Schizandra powder or extract, Astragalus powder or extract, Onion powder or extract, Stevia powder or extract, and the like can be exemplified.
- the meaning of the extract in the above is as described in relation to the tomato outpost extract of the bar except for the extraction target.
- Such extracts may be obtained by mixing the extraction objects.
- composition of this invention can be grasped
- the food composition of the present invention may include a sweetener, a flavoring agent, a bioactive component, a mineral component, and the like.
- Sweeteners may be used in amounts that give the food a suitable sweet taste, and may be natural or synthetic.
- a natural sweetener is used.
- sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.
- Flavoring agents can be used to enhance the taste or aroma of foods, both natural and synthetic. It is the case of using a natural thing preferably.
- the natural flavor may be obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or may be obtained from green tea leaves, round leaves, date leaves, cinnamon, chrysanthemum leaves, jasmine and the like.
- ginseng red ginseng
- bamboo shoots aloe vera, ginkgo and the like
- Natural flavors can be liquid concentrates or solid extracts.
- synthetic flavoring agents may be used, and synthetic flavoring agents may include esters, alcohols, aldehydes, terpenes, and the like.
- catechins such as catechin, epicatechin, gallocatechin, epigallocatechin, vitamins such as retinol, ascorbic acid, tocopherol, calciferol, thiamine, riboflavin, and the like can be used.
- mineral component calcium, magnesium, chromium, cobalt, copper, fluoride, germanium, iodine, iron, lithium, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, silicon, sodium, sulfur, vanadium, zinc and the like can be used. .
- the food composition of the present invention may contain a preservative, an emulsifier, an acidulant, a thickener, and the like, in addition to the sweetener.
- Such preservatives, emulsifiers and the like are preferably added and used in very small amounts as long as the use to which they are added can be achieved.
- trace amounts numerically means 0.0005% to about 0.5% by weight, based on the total weight of the food composition.
- preservatives examples include sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, EDTA (ethylenediaminetetraacetic acid), and the like.
- Emulsifiers that can be used include acacia gum, carboxymethylcellulose, xanthan gum, pectin and the like.
- acidulants examples include lead acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid, and the like. Such acidulant may be added so that the food composition is at an appropriate acidity for the purpose of inhibiting the growth of microorganisms in addition to the purpose of enhancing taste.
- Thickeners that can be used include suspending implements, sedimenters, gel formers, swelling agents and the like.
- composition of the present invention can be used as a pharmaceutical composition in a specific embodiment.
- compositions of the present invention in addition to the active ingredient, pharmaceutically acceptable carriers, excipients, and the like, oral formulations (tablets, suspensions, granules, emulsions, capsules, syrups, etc.), parenteral formulations (sterile injectable aqueous) Or oily suspensions), topical formulations (solutions, creams, ointments, gels, lotions, patches) and the like.
- pharmaceutically acceptable means that the subject of application (prescription) does not have more toxicity (adequately less toxic) than is applicable without inhibiting the activity of the active ingredient.
- Examples of pharmaceutically acceptable carriers include lactose, glucose, sucrose, starch (such as corn starch, potato starch, etc.), cellulose, derivatives thereof (such as sodium carboxymethyl cellulose, ethylcellulose, etc.), malt, gelatin, talc, Solid lubricants (such as stearic acid, magnesium stearate, etc.), calcium sulfate, vegetable oils (such as peanut oil, cottonseed oil, sesame oil, olive oil, etc.), polyols (such as propylene glycol, glycerin, etc.), alginic acid, emulsifiers (such as TWEENS), wetting agents (Such as sodium lauryl sulfate), colorants, flavors, tableting agents, stabilizers, antioxidants, preservatives, water, saline, phosphate buffer solutions, and the like.
- Such a carrier may be used by selecting one or more appropriate ones according to the formulation of the pharmaceutical composition of the present invention.
- Excipients may be selected and used according to the formulation of the pharmaceutical composition of the present invention, for example, when the pharmaceutical composition of the present invention is prepared with an aqueous suspending agent, suitable excipients are sodium carboxymethyl cellulose, methyl cellulose, hydropropylmethylcellulose And suspending agents and dispersing agents such as sodium alginate and polyvinylpyrrolidone. Suitable excipients when prepared as injections include Ringer's solution, isotonic sodium chloride, and the like.
- the pharmaceutical composition of the present invention may be administered orally or parenterally and in some cases may be administered topically.
- the daily dosage of the pharmaceutical composition of the present invention is usually 0.001 ⁇ 150 mg / kg body weight range, it can be administered once or divided into several times. However, since the dosage of the pharmaceutical composition of the present invention is determined in view of various related factors such as the route of administration, the age, sex, weight of the patient, and the severity of the patient, the dosage may limit the scope of the present invention in any aspect. It should not be understood as.
- composition of the present invention can provide a composition for smoking toxicity detox using tomato outpost extract and the like.
- the composition of the present invention can be used as a food composition or pharmaceutical composition, such as gum, beverages.
- 1 is a laboratory test result showing the nicotine removal activity of tomato outpost extract.
- Figure 2 is a test tube experiment showing the nicotine removal activity of baekhwasachocho extract.
- Figure 3 is a laboratory test result showing the nicotine removal activity of rowan extract.
- Figure 4 is a laboratory test result showing the nicotine removal activity of the branch extract.
- 5 is a test tube experiment showing the nicotine removal activity of the alder extract.
- the experimental animals purchased rats without Sprague-Dawley-type specific pathogens weighing 260-280g, 6 weeks old ⁇ Central Laboratory Animals, South Korea ⁇ and the temperature was 21 ⁇ 2 °C and lighting time 12L / 12D in the animal breeding room before the experiment started. A sufficient amount of water and solid feed were provided, and 5 dogs were separated and adapted to the test environment for 2 weeks.
- the experimental animals were divided into 6 groups (1 group: control group, 5 groups: experimental group) of 5 animals, and the experimental group was mixed with a solid feed at 1.0 g / kg / day and mixed with water for 7 days.
- nicotine was intraperitoneally administered at 3 mg / kg
- the control group was intraperitoneally administered at only 3 mg / kg of nicotine without administering the extract of Example.
- 1 ml of blood was drawn from the heart to measure the concentration of nicotine in the blood.
- the blood was adjusted to pH 9.0 with dilute ammonia water, then maintained in an EXTRELUT COLUMN (Merk) for 15 minutes, eluted with 15 ml of ethyl acetate, and the eluted acetate was distilled under reduced pressure and distillation. After removal, 100 ⁇ l of ethyl acetate was added to the resulting powder to dissolve to prepare an analytical sample. Analysis was performed using gas chromatography (Gas Chromatography-Mass Spectrometer, FISONS Instruments Co.).
- the nicotine concentration in blood is shown in Table 2 below with MEAN ⁇ SD.
- Experimental groups 1 to 5 are experimental groups to which the extracts of Examples 1 to 5 were administered, respectively.
- mice Five animals were used as the experimental group of 1 group, and the animals were intraperitoneally administered with tar at a dose of 30 mg / kg / 10ml, and then the extract of each of the above examples was administered at the dose of 1.0g / kg / 1 day. Oral administration together for 7 days was observed for survival.
- the control group was administered distilled water instead of the extract of the example.
- beverage of the preparation example was performed to improve the symptoms according to the smoker smoking as follows.
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
함량(중량%) | |
실시예 1의 추출물 | 2.0 |
실시예 2의 추출물 | 2.0 |
실시예 3의 추출물 | 2.0 |
실시예 4의 추출물 | 2.0 |
실시예 5의 추출물 | 2.0 |
꿀 | 10.0 |
자몽씨 추출액(천연 방부제) | 1.0 |
정제수 | 잔량(to 100) |
구분 | 혈중 니코틴 농도 (㎍/㎖) |
실험군 1 | 1.20±0.13 |
실험군 2 | 1.74±0.15 |
실험군 3 | 1.72±0.09 |
실험군 4 | 1.93±0.12 |
실험군 5 | 1.64±0.13 |
대조군 | 2.28±0.12 |
* 실험군 1 내지 5는 각각 실시예 1 내지 5의 추출물을 투여한 실험군임. |
구분 | 사망한 개체수 | 총 생존개체수 | ||||||
1일 | 2일 | 3일 | 4일 | 5일 | 6일 | 7일 | ||
실험군 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
실험군 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
실험군 3 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 |
실험군 4 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3 |
실험군 5 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 |
대조군 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
구분 | 크게개선 | 대단히개선 | 보통개선 | 약간개선 | 효과없음 |
입냄새 | 72 | 18 | 4 | 4 | 2 |
가 래 | 68 | 21 | 6 | 3 | 2 |
기 침 | 54 | 26 | 10 | 5 | 5 |
구역질 | 66 | 14 | 14 | 4 | 2 |
Claims (16)
- 토마토 전초 추출물, 백화사설초 추출물, 마가목 추출물, 지치 추출물 및 오리나무 추출물 중 하나 이상의 추출물을 유효성분으로 포함함을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 토마토 전초 추출물은 토마토 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 메탄올, 에탄올, 아세톤, 에틸아세테이트, 포화노말부탄올, 클로로포름, 메틸렌클로라이드, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 토마토 전초 추출물은 토마토 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 에탄올, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 백화사설초 추출물은 백화사설초 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 메탄올, 에탄올, 아세톤, 에틸아세테이트, 포화노말부탄올, 클로로포름, 메틸렌클로라이드, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 백화사설초 추출물은 백화사설초 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 에탄올, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 마가목 추출물은 마가목 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 메탄올, 에탄올, 아세톤, 에틸아세테이트, 포화노말부탄올, 클로로포름, 메틸렌클로라이드, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 마가목 추출물은 마가목 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 에탄올, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 지치 추출물은 지치 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 메탄올, 에탄올, 아세톤, 에틸아세테이트, 포화노말부탄올, 클로로포름, 메틸렌클로라이드, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 지치 추출물은 지치 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 에탄올, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 오리나무 추출물은 오리나무 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 메탄올, 에탄올, 아세톤, 에틸아세테이트, 포화노말부탄올, 클로로포름, 메틸렌클로라이드, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 오리나무 추출물은 오리나무 잎, 줄기, 꽃, 뿌리 또는 이들의 혼합물을 에탄올, 물 또는 이들의 혼합 용매로 추출하여 얻어진 추출물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 흡연 독성 해독용 조성물은 유효성분으로 토마토 전초 추출물, 백화사설초 추출물, 마가목 추출물, 지치 추출물 및 오리나무 추출물 모두를 포함하는 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항에 있어서,상기 조성물은 녹차 분말 또는 추출물, 흑두(黑豆) 분말 또는 추출물, 포공영(蒲公英) 분말 또는 추출물, 금은화 분말 또는 추출물, 삼백초 분말 또는 추출물, 결명자 분말 또는 추출물, 감초 분말 또는 추출물, 산사자 분말 또는 추출물, 고본 분말 또는 추출물, 오가피 분말 또는 추출물, 하수오 분말 또는 추출물, 전호 분말 또는 추출물, 정향 분말 또는 추출물, 진피(진귤의 껍질) 분말 또는 추출물, 나복자 분말 또는 추출물, 질경 분말 또는 추출물, 알로에 분말 또는 추출물, 오미자 분말 또는 추출물, 황기 분말 또는 추출물, 양파 분말 또는 추출물 및 스테비아 분말 또는 추출물로 구성된 군에서 선택된 분말 또는 추출물을 하나 이상 추가로 포함함을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항 내지 제13항 중 어느 한 항에 있어서,상기 흡연 독성 해독용 조성물은 식품 조성물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제14항에 있어서,상기 식품 조성물은 음료, 껌 또는 젤리인 것을 특징으로 하는 흡연 독성 해독용 조성물.
- 제1항 내지 제13항 중 어느 한 항에 있어서,상기 흡연 독성 해독용 조성물은 약제학적 조성물인 것을 특징으로 하는 흡연 독성 해독용 조성물.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/509,595 US20120225140A1 (en) | 2009-11-11 | 2010-04-20 | Composition for counteracting smoking toxicity |
EP10830081A EP2500027A1 (en) | 2009-11-11 | 2010-04-20 | Composition for counteracting smoking toxicity |
CN2010800507548A CN102596213A (zh) | 2009-11-11 | 2010-04-20 | 解烟毒的组合物 |
JP2012537792A JP5459643B2 (ja) | 2009-11-11 | 2010-04-20 | 喫煙毒性解毒用組成物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2009-0108686 | 2009-11-11 | ||
KR1020090108686A KR20110051876A (ko) | 2009-11-11 | 2009-11-11 | 흡연 독성 해독용 조성물 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011059148A1 true WO2011059148A1 (ko) | 2011-05-19 |
Family
ID=43991792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2010/002456 WO2011059148A1 (ko) | 2009-11-11 | 2010-04-20 | 흡연 독성 해독용 조성물 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20120225140A1 (ko) |
EP (1) | EP2500027A1 (ko) |
JP (1) | JP5459643B2 (ko) |
KR (1) | KR20110051876A (ko) |
CN (5) | CN103479791A (ko) |
WO (1) | WO2011059148A1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103704457A (zh) * | 2013-12-24 | 2014-04-09 | 谭淋姗 | 一种戒烟糖 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104306580A (zh) * | 2014-11-03 | 2015-01-28 | 杨征 | 一种用于辅助戒烟的中药组合物 |
KR102261122B1 (ko) * | 2020-07-14 | 2021-06-07 | 농업회사법인 주식회사 오케이120 | 혈중 니코틴 농도 감소용 조성물 |
CN115026114A (zh) * | 2022-06-10 | 2022-09-09 | 环保桥(湖南)生态环境工程股份有限公司 | 一种利用金边龙舌兰治理并修复苯并[a]芘污染土壤的方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040102690A (ko) | 2003-05-29 | 2004-12-08 | (주)내츄럴엔도텍 | 천연 식물 추출물을 유효성분으로 포함하는 니코틴무독화용 조성물 |
CN1555851A (zh) * | 2004-01-12 | 2004-12-22 | 李�灿 | 一种具有清肺功能的组合物及其制备方法 |
KR100494223B1 (ko) | 2005-01-26 | 2005-06-16 | (주)세포활성연구소 | 니코틴 및 타르 해독을 위한 복합 천연 조성물 |
KR20090025851A (ko) * | 2007-09-07 | 2009-03-11 | 오옥수 | 금연 보조 음료의 제조방법 및 그 방법에 의하여 제조된금연 보조 음료 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60169413A (ja) * | 1984-02-15 | 1985-09-02 | Mitsui Petrochem Ind Ltd | 口腔衛生組成物 |
US5391568A (en) * | 1992-07-10 | 1995-02-21 | American Health Foundation | Inhibition of lung tumorigenesis by administration of a polyphenol |
KR0181168B1 (ko) * | 1996-11-07 | 1999-02-01 | 남종현 | 숙취해소용 천연차 및 그 제조방법 |
JPH10287582A (ja) * | 1997-04-09 | 1998-10-27 | Ogawa Koryo Kk | 樹皮抽出物からなるヒスタミン遊離抑制剤 |
KR20020023770A (ko) * | 2001-12-17 | 2002-03-29 | 김규안 | 오리나무를 이용한 숙취해소제 |
JP2003261435A (ja) * | 2002-03-11 | 2003-09-16 | Ichimaru Pharcos Co Ltd | エネルギー変性剤 |
JP4393777B2 (ja) * | 2002-03-19 | 2010-01-06 | 株式会社ファンケル | 抗ヘリコバクター・ピロリ用組成物 |
CN1165509C (zh) * | 2002-03-19 | 2004-09-08 | 中山大学 | 紫草萘醌类衍生物及其在制备抗癌药物中的应用 |
KR100484223B1 (ko) * | 2003-06-23 | 2005-04-20 | (주)클릭앤콜 | 지역정보 검색서비스 시스템 |
CN101522183A (zh) * | 2006-08-02 | 2009-09-02 | 秋久俊博 | 骨病预防及/或治疗用医药组合物、含有该组合物的功能性食品或健康食品、以及以该组合物为有效成分的医药制剂 |
CN101023973B (zh) * | 2006-12-01 | 2010-07-07 | 广州中医药大学第二附属医院 | 紫草多糖提取物、含紫草多糖提取物的组合物及其用途 |
JP2008142064A (ja) * | 2006-12-06 | 2008-06-26 | Shizen Kaiki Kenkyusho:Kk | トマトの葉及び枝の有効利用法 |
CN101011481B (zh) * | 2007-01-29 | 2011-08-10 | 周应军 | 白花蛇舌草提取物及其药物制剂、制备方法和应用 |
JP2008214250A (ja) * | 2007-03-02 | 2008-09-18 | Hokkaido Mitsui Chemicals Inc | メイラード反応阻害剤 |
JP2008214299A (ja) * | 2007-03-07 | 2008-09-18 | Innovatis Pharma Corp | パパイヤおよび白花蛇舌草の水溶性抽出成分を含む癌の予防、治療または改善のための組成物 |
KR20090002581A (ko) * | 2007-07-02 | 2009-01-09 | 삼성전기주식회사 | 잡광 제거 장치 |
CN101148785B (zh) * | 2007-10-19 | 2010-05-19 | 东华大学 | 防治皮肤病的紫草药用聚丙烯腈纤维、其制备方法和应用 |
KR100923884B1 (ko) * | 2007-12-11 | 2009-10-28 | 주식회사 알앤엘바이오 | 항인플루엔자 바이러스 활성이 높은 오리나무 수피 또는줄기 추출물의 제조방법 |
KR101483440B1 (ko) * | 2008-05-02 | 2015-01-19 | (주)아모레퍼시픽 | 포제를 활용한 약용식물 추출물 및 이를 함유하는 피부외용제 조성물 |
-
2009
- 2009-11-11 KR KR1020090108686A patent/KR20110051876A/ko not_active Application Discontinuation
-
2010
- 2010-04-20 CN CN201310409828.8A patent/CN103479791A/zh active Pending
- 2010-04-20 CN CN201310409829.2A patent/CN103479762A/zh active Pending
- 2010-04-20 WO PCT/KR2010/002456 patent/WO2011059148A1/ko active Application Filing
- 2010-04-20 EP EP10830081A patent/EP2500027A1/en not_active Withdrawn
- 2010-04-20 JP JP2012537792A patent/JP5459643B2/ja active Active
- 2010-04-20 US US13/509,595 patent/US20120225140A1/en not_active Abandoned
- 2010-04-20 CN CN2010800507548A patent/CN102596213A/zh active Pending
- 2010-04-20 CN CN201310410438.2A patent/CN103478833A/zh active Pending
- 2010-04-20 CN CN201310409846.6A patent/CN103479705A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040102690A (ko) | 2003-05-29 | 2004-12-08 | (주)내츄럴엔도텍 | 천연 식물 추출물을 유효성분으로 포함하는 니코틴무독화용 조성물 |
CN1555851A (zh) * | 2004-01-12 | 2004-12-22 | 李�灿 | 一种具有清肺功能的组合物及其制备方法 |
KR100494223B1 (ko) | 2005-01-26 | 2005-06-16 | (주)세포활성연구소 | 니코틴 및 타르 해독을 위한 복합 천연 조성물 |
KR20090025851A (ko) * | 2007-09-07 | 2009-03-11 | 오옥수 | 금연 보조 음료의 제조방법 및 그 방법에 의하여 제조된금연 보조 음료 |
Non-Patent Citations (10)
Title |
---|
BARLOW R. D; STONE R. B., CLIN. CHIM. ACTA., vol. 165, 1987, pages 45 |
BRUNNEMAN, K. D. ET AL., J. NATL. CANCER INST., vol. 89, 1996, pages 868 - 73 |
BRUNNEMANN, K.D.; HOFFIMAN D., TOXCOL, vol. 21, no. 91, pages 235 |
CARMELLA, S. G. ET AL., CANCER EPIDEMIOL BIOMARKERS PREV., vol. 6, 1997, pages 113 - 20 |
CHUNG. F. L., PROC. SOC. EXP. VIOL. MED., vol. 220, 1999, pages 244 - 248 |
FUJIKI, H. ET AL., MUTAT. RES., vol. 18, 1998, pages 307 - 310 |
MPOWER: "WHO report on the global tobacco epidemic", 2008, WHO |
SHIN D C: "Toxic Chemicals in Tobacco Smoke", 1999, KOREAN ASSOCIATION OF ANTISMOKING |
WYNDER, E. L. ET AL., ENVIRON HEALTH PERSPECT., vol. 103, no. 8, 1995, pages 143 - 148 |
YOON, SEOK JUN ET AL.: "Estimation of Attributable Burden due to Premature Death from Smoking in Korea", JOURNAL OF PREVENTIVE MEDICINE AND PUBLIC HEALTH, vol. 34, no. 3, 2001 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103704457A (zh) * | 2013-12-24 | 2014-04-09 | 谭淋姗 | 一种戒烟糖 |
Also Published As
Publication number | Publication date |
---|---|
CN103479705A (zh) | 2014-01-01 |
EP2500027A1 (en) | 2012-09-19 |
CN103479791A (zh) | 2014-01-01 |
JP2013510139A (ja) | 2013-03-21 |
CN103478833A (zh) | 2014-01-01 |
CN103479762A (zh) | 2014-01-01 |
KR20110051876A (ko) | 2011-05-18 |
CN102596213A (zh) | 2012-07-18 |
JP5459643B2 (ja) | 2014-04-02 |
US20120225140A1 (en) | 2012-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100968109B1 (ko) | 칼슘 화합물을 주성분으로 한 천연 원료의 숙취 해소용조성물 및 이의 제조 방법 | |
WO2016099043A1 (ko) | 숙취해소용 및 간기능 개선용 음료 조성물 | |
WO2011059148A1 (ko) | 흡연 독성 해독용 조성물 | |
WO2011059150A1 (ko) | 간 기능 개선제 조성물 | |
KR100552398B1 (ko) | 작두콩 추출물을 포함하는 숙취해소용 음료조성물 | |
WO2016060394A1 (ko) | 인삼의 쓴맛 억제제 및 이를 포함하는 인삼 조성물 | |
KR101324431B1 (ko) | 숙취해소용 조성물 | |
CN106581115B (zh) | 含芫根和人参的组合物及其应用 | |
KR20100025303A (ko) | 인삼 사포닌의 기능이 강화된 기능성 음료 조성물 | |
KR101076127B1 (ko) | 오리나무 추출물을 유효성분으로 하는 흡연독성 해독용 약제학적 조성물 | |
KR101076482B1 (ko) | 마가목 추출물을 유효성분으로 하는 흡연독성 해독용 약제학적 조성물 | |
KR20190133633A (ko) | 고추나물 추출물을 이용한 만성폐쇄성폐질환 개선용 조성물 | |
KR101134200B1 (ko) | 백화사설초 추출물을 유효성분으로 하는 흡연독성 해독용 약제학적 조성물 | |
KR20150063905A (ko) | 해당화 추출물을 유효성분으로 포함하는 알코올성 간질환 예방 또는 치료용, 또는 숙취해소용 조성물 | |
KR101076515B1 (ko) | 지치 추출물을 유효성분으로 하는 흡연독성 해독용 약제학적 조성물 | |
KR101968891B1 (ko) | 멀꿀 열매 추출물을 유효성분으로 포함하는 혈중알콜농도 저감 촉진용 조성물 | |
KR20040047617A (ko) | 니코틴제거 효과가 있는 조성물 및 그 제조 방법 | |
KR20110059580A (ko) | 마가목 추출물을 유효성분으로 하는 흡연독성 해독용 식품조성물 | |
KR20110059582A (ko) | 오리나무 추출물을 유효성분으로 하는 흡연독성 해독용 식품조성물 | |
KR20110059579A (ko) | 백화사설초 추출물을 유효성분으로 하는 흡연독성 해독용 식품조성물 | |
KR20110059581A (ko) | 지치 추출물을 유효성분으로 하는 흡연독성 해독용 식품조성물 | |
KR20200135640A (ko) | 강황 추출물, 황금 추출물 등을 이용한 천식 또는 만성폐쇄성폐질환 개선용 조성물 | |
KR20120029117A (ko) | 니코틴 분해 촉진용 조성물 | |
US20240307478A1 (en) | Phosphodiesterase 5 inhibitor | |
KR101849662B1 (ko) | 쇠비름 추출물을 주성분으로 하는 숙취 예방 및 해소용 생약 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201080050754.8 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10830081 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010830081 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2012537792 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 13509595 Country of ref document: US |