WO2011019781A1 - Procédé pour la préparation de composés de benzimidazole substitués par 2-arylamino ou hétéroarylamino - Google Patents

Procédé pour la préparation de composés de benzimidazole substitués par 2-arylamino ou hétéroarylamino Download PDF

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Publication number
WO2011019781A1
WO2011019781A1 PCT/US2010/045110 US2010045110W WO2011019781A1 WO 2011019781 A1 WO2011019781 A1 WO 2011019781A1 US 2010045110 W US2010045110 W US 2010045110W WO 2011019781 A1 WO2011019781 A1 WO 2011019781A1
Authority
WO
WIPO (PCT)
Prior art keywords
process according
optionally substituted
pyridyl
compound
formula
Prior art date
Application number
PCT/US2010/045110
Other languages
English (en)
Inventor
John J. Shay, Jr.
Sithamalli V. Chandramouli
Xiaojie Li
Matthew R. Powers
Timothy A. Ayers
Andrea Hillegass
Original Assignee
Sanofi-Aventis U.S. Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis U.S. Llc filed Critical Sanofi-Aventis U.S. Llc
Publication of WO2011019781A1 publication Critical patent/WO2011019781A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Abstract

La présente invention porte sur un procédé pour la préparation de composés de benzimidazole substitués par 2-arylamino ou hétéroarylamino.
PCT/US2010/045110 2009-08-11 2010-08-11 Procédé pour la préparation de composés de benzimidazole substitués par 2-arylamino ou hétéroarylamino WO2011019781A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23293209P 2009-08-11 2009-08-11
US61/232,932 2009-08-11

Publications (1)

Publication Number Publication Date
WO2011019781A1 true WO2011019781A1 (fr) 2011-02-17

Family

ID=42752011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/045110 WO2011019781A1 (fr) 2009-08-11 2010-08-11 Procédé pour la préparation de composés de benzimidazole substitués par 2-arylamino ou hétéroarylamino

Country Status (3)

Country Link
AR (1) AR077823A1 (fr)
TW (1) TW201111350A (fr)
WO (1) WO2011019781A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3015469A1 (fr) 2014-10-30 2016-05-04 Idemitsu Kosan Co., Ltd. 5-((benz)imidazol-2-yl)benzimidazo[1,2-a]benzimidazoles pour des applications électroniques
KR101850282B1 (ko) * 2014-11-26 2018-05-31 한국과학기술연구원 단백질 키나아제 저해제로 유용한 헤테로아릴아민 유도체
CN111978319A (zh) * 2014-06-27 2020-11-24 诺格拉制药有限公司 芳基受体调制剂及其制备和使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058870A1 (fr) * 2003-12-18 2005-06-30 Tibotec Pharmaceuticals Ltd. Derives amino-benzimidazoles utilises en tant qu'inhibiteurs de la replication du virus syncytial respiratoire
US7049333B2 (en) 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7049333B2 (en) 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
WO2005058870A1 (fr) * 2003-12-18 2005-06-30 Tibotec Pharmaceuticals Ltd. Derives amino-benzimidazoles utilises en tant qu'inhibiteurs de la replication du virus syncytial respiratoire

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
OZDEN S ET AL: "Synthesis, potent anti-staphylococcal activity and QSARs of some novel 2-anilinobenzazoles", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR LNKD- DOI:10.1016/J.EJMECH.2007.10.009, vol. 43, no. 7, 1 July 2008 (2008-07-01), pages 1390 - 1402, XP022795983, ISSN: 0223-5234, [retrieved on 20071011] *
P. LAN ET AL., TETRAHEDRON LETTERS, vol. 49, 2008, pages 1910 - 1914
TUNCBILEK M ET AL: "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW ANILINO BENZIMIDAZOLES", ARCHIV DER PHARMAZIE, WILEY - VCH VERLAG GMBH & CO. KGAA, DE LNKD- DOI:10.1002/ARDP.19973301203, vol. 330, no. 12, 1 December 1997 (1997-12-01), pages 372 - 376, XP001064267, ISSN: 0365-6233 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111978319A (zh) * 2014-06-27 2020-11-24 诺格拉制药有限公司 芳基受体调制剂及其制备和使用方法
CN111978319B (zh) * 2014-06-27 2023-08-11 诺格拉制药有限公司 芳基受体调制剂及其制备和使用方法
EP3015469A1 (fr) 2014-10-30 2016-05-04 Idemitsu Kosan Co., Ltd. 5-((benz)imidazol-2-yl)benzimidazo[1,2-a]benzimidazoles pour des applications électroniques
WO2016067261A1 (fr) 2014-10-30 2016-05-06 Idemitsu Kosan Co., Ltd. 5-((benz)imidazol-2-yl) benzimidazo[1,2-a]benzimidazoles utilisés pour des applications électroniques
KR101850282B1 (ko) * 2014-11-26 2018-05-31 한국과학기술연구원 단백질 키나아제 저해제로 유용한 헤테로아릴아민 유도체

Also Published As

Publication number Publication date
AR077823A1 (es) 2011-09-28
TW201111350A (en) 2011-04-01

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