WO2010104345A2 - 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법 - Google Patents

실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법 Download PDF

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Publication number
WO2010104345A2
WO2010104345A2 PCT/KR2010/001530 KR2010001530W WO2010104345A2 WO 2010104345 A2 WO2010104345 A2 WO 2010104345A2 KR 2010001530 W KR2010001530 W KR 2010001530W WO 2010104345 A2 WO2010104345 A2 WO 2010104345A2
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WO
WIPO (PCT)
Prior art keywords
nucleic acid
same
detecting
integrated real
time
Prior art date
Application number
PCT/KR2010/001530
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English (en)
French (fr)
Other versions
WO2010104345A3 (ko
Inventor
김유정
구완림
김종훈
장대진
서진철
김성열
박해준
박한오
Original Assignee
(주)바이오니아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)바이오니아 filed Critical (주)바이오니아
Priority to CA2755234A priority Critical patent/CA2755234C/en
Priority to US13/255,646 priority patent/US20120135394A1/en
Priority to CN201080011492.4A priority patent/CN102388148B/zh
Priority to RU2011141128/10A priority patent/RU2532853C2/ru
Priority to EP10751036.4A priority patent/EP2407557B1/en
Priority to JP2011553957A priority patent/JP5774499B2/ja
Priority to BRPI1008957A priority patent/BRPI1008957B8/pt
Priority to AU2010221905A priority patent/AU2010221905B2/en
Publication of WO2010104345A2 publication Critical patent/WO2010104345A2/ko
Publication of WO2010104345A3 publication Critical patent/WO2010104345A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/30—Combinations with other devices, not otherwise provided for
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • C12M1/38—Temperature-responsive control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

본 발명은 실시간 핵산 분석 통합 장치 및 이를 이용한 방법에 관한 것으로 보다 상세하게는 다양한 종류의 다수의 생물학적 시료로부터 시료에 상응되는 유전자의 정성분석 또는 정량분석을 동시에 수행하는 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법으로, 상기 본 발명에 따른 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법은 다양한 검체로부터 요구되는 다양한 타겟의 검사가 단 한번으로 신속하고 정확하게 처리되어 병의 진단이 필요한 병원 등에서 효율적으로 사용할 수 있는 장점이 있다.
PCT/KR2010/001530 2009-03-11 2010-03-11 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법 WO2010104345A2 (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2755234A CA2755234C (en) 2009-03-11 2010-03-11 Method of integrated real-time nucleic acid analysis for simultaneously detecting a plurality of target nucleic acids
US13/255,646 US20120135394A1 (en) 2009-03-11 2010-03-11 Apparatus for integrated real-time nucleic acid analysis, and method for detecting a target nucleic acid using same
CN201080011492.4A CN102388148B (zh) 2009-03-11 2010-03-11 实时核酸分析整合装置及利用该装置的靶核酸检测方法
RU2011141128/10A RU2532853C2 (ru) 2009-03-11 2010-03-11 Устройство для интегрального анализа нуклеиновых кислот в реальном времени и способ определения целевой нуклеиновой кислоты с его использованием
EP10751036.4A EP2407557B1 (en) 2009-03-11 2010-03-11 Apparatus for integrated real-time nucleic acid analysis, and method for detecting a target nucleic acid using same
JP2011553957A JP5774499B2 (ja) 2009-03-11 2010-03-11 リアルタイム核酸分析統合装置及びそれを利用したターゲット核酸の検出方法
BRPI1008957A BRPI1008957B8 (pt) 2009-03-11 2010-03-11 método para detecção simultânea de uma pluralidade de ácidos nucleicos alvo executado por um sistema de análise integrada em tempo real de ácidos nucleicos alvo
AU2010221905A AU2010221905B2 (en) 2009-03-11 2010-03-11 Apparatus for integrated real-time nucleic acid analysis, and method for detecting a target nucleic acid using same

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR20090020913 2009-03-11
KR10-2009-0020913 2009-03-11
KR20100002027 2010-01-08
KR10-2010-002027 2010-01-08
KR1020100021532A KR101423936B1 (ko) 2009-03-11 2010-03-10 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법
KR10-2010-0021532 2010-03-10

Publications (2)

Publication Number Publication Date
WO2010104345A2 true WO2010104345A2 (ko) 2010-09-16
WO2010104345A3 WO2010104345A3 (ko) 2011-01-13

Family

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Family Applications (1)

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PCT/KR2010/001530 WO2010104345A2 (ko) 2009-03-11 2010-03-11 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법

Country Status (11)

Country Link
US (1) US20120135394A1 (ko)
EP (1) EP2407557B1 (ko)
JP (1) JP5774499B2 (ko)
KR (1) KR101423936B1 (ko)
CN (1) CN102388148B (ko)
AU (1) AU2010221905B2 (ko)
BR (1) BRPI1008957B8 (ko)
CA (1) CA2755234C (ko)
CL (1) CL2011002228A1 (ko)
RU (1) RU2532853C2 (ko)
WO (1) WO2010104345A2 (ko)

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CN103484534A (zh) * 2013-06-19 2014-01-01 兰州百源基因技术有限公司 一组用于淋病奈瑟氏菌实时荧光pcr检测的引物和探针及其应用
CN105518462A (zh) * 2013-09-12 2016-04-20 西门子医疗保健诊断公司 动态测定选择和样本制备装置和方法及其机器可读介质
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KR101707987B1 (ko) * 2015-06-16 2017-02-21 휴스텝스 주식회사 자동 정량 분주기 및 상기 분주기를 포함하는 연속식 유전자 추출-증폭 장비와 연속식 유전자 추출-증폭 방법
KR20180103945A (ko) * 2016-02-05 2018-09-19 젠-프로브 인코포레이티드 건조된 증폭 조성물
WO2017154567A1 (ja) * 2016-03-11 2017-09-14 パナソニック株式会社 試料分析方法及び試料分析装置
WO2018074614A1 (ko) * 2016-10-17 2018-04-26 휴스텝스 주식회사 자동 정량 분주기 및 상기 분주기를 포함하는 연속식 유전자 추출-증폭 장비와 연속식 유전자 추출-증폭 방법
WO2019022753A1 (en) * 2017-07-28 2019-01-31 Hewlett-Packard Development Company, L.P. INTERROGATION AND DETECTION OF IONIC SPECIES
WO2019066238A2 (ko) * 2017-09-28 2019-04-04 주식회사 씨젠 증폭 데이터 표시 방법 및 장치
CN109825416A (zh) * 2018-11-16 2019-05-31 苏州新波生物技术有限公司 一种全自动分子诊断系统及分子诊断方法
CN114667338A (zh) * 2019-09-20 2022-06-24 美国西门子医学诊断股份有限公司 用于在样品制备期间搅拌流体的改进的转子混合器
CN110951580B (zh) * 2019-09-29 2022-05-20 中国科学院苏州生物医学工程技术研究所 高通量单细胞转录组与基因突变整合分析一体化装置
US20230183784A1 (en) * 2020-05-13 2023-06-15 Ohio State Innovation Foundation Quadruplex-based detection of a target nucleic acid
CN111812131B (zh) * 2020-07-21 2020-12-25 中国科学院地质与地球物理研究所 水合物二次生成或分解过程的可视化试验系统及方法
CN111849758A (zh) * 2020-08-18 2020-10-30 上海基灵生物科技有限公司 全自动实时荧光定量pcr检测系统
KR102581063B1 (ko) * 2020-12-31 2023-09-22 한국기계연구원 고속 온도제어가 가능한 고속 분자진단장치 및 이를 이용한 고속 분자진단방법
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JP2013541959A (ja) * 2010-10-27 2013-11-21 バイオニア コーポレーション 多様な生体試料分析のための自動リアルタイムｐｃｒシステム
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CN104204229A (zh) * 2012-02-10 2014-12-10 株式会社百奥尼 用于自动分析生物试样的设备以及方法
CN104204229B (zh) * 2012-02-10 2016-09-07 株式会社百奥尼 用于自动分析生物试样的设备以及方法

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CN102388148A (zh) 2012-03-21
AU2010221905A1 (en) 2011-10-06
KR101423936B1 (ko) 2014-07-29
JP5774499B2 (ja) 2015-09-09
WO2010104345A3 (ko) 2011-01-13
CA2755234A1 (en) 2010-09-16
EP2407557B1 (en) 2020-05-20
EP2407557A2 (en) 2012-01-18
RU2011141128A (ru) 2013-04-20
CL2011002228A1 (es) 2012-03-23
US20120135394A1 (en) 2012-05-31
KR20100102560A (ko) 2010-09-24
BRPI1008957B1 (pt) 2020-04-22
CN102388148B (zh) 2017-05-17
JP2012523820A (ja) 2012-10-11
EP2407557A4 (en) 2016-05-25
BRPI1008957A2 (pt) 2016-03-15
CA2755234C (en) 2020-06-30
BRPI1008957B8 (pt) 2021-07-27
AU2010221905B2 (en) 2015-04-16
RU2532853C2 (ru) 2014-11-10

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