WO2010104345A2 - 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법 - Google Patents

실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법 Download PDF

Info

Publication number
WO2010104345A2
WO2010104345A2 PCT/KR2010/001530 KR2010001530W WO2010104345A2 WO 2010104345 A2 WO2010104345 A2 WO 2010104345A2 KR 2010001530 W KR2010001530 W KR 2010001530W WO 2010104345 A2 WO2010104345 A2 WO 2010104345A2
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
same
detecting
integrated real
time
Prior art date
Application number
PCT/KR2010/001530
Other languages
English (en)
French (fr)
Other versions
WO2010104345A3 (ko
Inventor
김유정
구완림
김종훈
장대진
서진철
김성열
박해준
박한오
Original Assignee
(주)바이오니아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)바이오니아 filed Critical (주)바이오니아
Priority to JP2011553957A priority Critical patent/JP5774499B2/ja
Priority to CN201080011492.4A priority patent/CN102388148B/zh
Priority to BRPI1008957A priority patent/BRPI1008957B8/pt
Priority to CA2755234A priority patent/CA2755234C/en
Priority to RU2011141128/10A priority patent/RU2532853C2/ru
Priority to EP10751036.4A priority patent/EP2407557B1/en
Priority to AU2010221905A priority patent/AU2010221905B2/en
Priority to US13/255,646 priority patent/US20120135394A1/en
Publication of WO2010104345A2 publication Critical patent/WO2010104345A2/ko
Publication of WO2010104345A3 publication Critical patent/WO2010104345A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/30—Combinations with other devices, not otherwise provided for
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • C12M1/38—Temperature-responsive control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

본 발명은 실시간 핵산 분석 통합 장치 및 이를 이용한 방법에 관한 것으로 보다 상세하게는 다양한 종류의 다수의 생물학적 시료로부터 시료에 상응되는 유전자의 정성분석 또는 정량분석을 동시에 수행하는 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법으로, 상기 본 발명에 따른 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법은 다양한 검체로부터 요구되는 다양한 타겟의 검사가 단 한번으로 신속하고 정확하게 처리되어 병의 진단이 필요한 병원 등에서 효율적으로 사용할 수 있는 장점이 있다.
PCT/KR2010/001530 2009-03-11 2010-03-11 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법 WO2010104345A2 (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2011553957A JP5774499B2 (ja) 2009-03-11 2010-03-11 リアルタイム核酸分析統合装置及びそれを利用したターゲット核酸の検出方法
CN201080011492.4A CN102388148B (zh) 2009-03-11 2010-03-11 实时核酸分析整合装置及利用该装置的靶核酸检测方法
BRPI1008957A BRPI1008957B8 (pt) 2009-03-11 2010-03-11 método para detecção simultânea de uma pluralidade de ácidos nucleicos alvo executado por um sistema de análise integrada em tempo real de ácidos nucleicos alvo
CA2755234A CA2755234C (en) 2009-03-11 2010-03-11 Method of integrated real-time nucleic acid analysis for simultaneously detecting a plurality of target nucleic acids
RU2011141128/10A RU2532853C2 (ru) 2009-03-11 2010-03-11 Устройство для интегрального анализа нуклеиновых кислот в реальном времени и способ определения целевой нуклеиновой кислоты с его использованием
EP10751036.4A EP2407557B1 (en) 2009-03-11 2010-03-11 Apparatus for integrated real-time nucleic acid analysis, and method for detecting a target nucleic acid using same
AU2010221905A AU2010221905B2 (en) 2009-03-11 2010-03-11 Apparatus for integrated real-time nucleic acid analysis, and method for detecting a target nucleic acid using same
US13/255,646 US20120135394A1 (en) 2009-03-11 2010-03-11 Apparatus for integrated real-time nucleic acid analysis, and method for detecting a target nucleic acid using same

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR10-2009-0020913 2009-03-11
KR20090020913 2009-03-11
KR20100002027 2010-01-08
KR10-2010-002027 2010-01-08
KR10-2010-0021532 2010-03-10
KR1020100021532A KR101423936B1 (ko) 2009-03-11 2010-03-10 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법

Publications (2)

Publication Number Publication Date
WO2010104345A2 true WO2010104345A2 (ko) 2010-09-16
WO2010104345A3 WO2010104345A3 (ko) 2011-01-13

Family

ID=43007600

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/001530 WO2010104345A2 (ko) 2009-03-11 2010-03-11 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법

Country Status (11)

Country Link
US (1) US20120135394A1 (ko)
EP (1) EP2407557B1 (ko)
JP (1) JP5774499B2 (ko)
KR (1) KR101423936B1 (ko)
CN (1) CN102388148B (ko)
AU (1) AU2010221905B2 (ko)
BR (1) BRPI1008957B8 (ko)
CA (1) CA2755234C (ko)
CL (1) CL2011002228A1 (ko)
RU (1) RU2532853C2 (ko)
WO (1) WO2010104345A2 (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013541959A (ja) * 2010-10-27 2013-11-21 バイオニア コーポレーション 多様な生体試料分析のための自動リアルタイムｐｃｒシステム
CN104204229A (zh) * 2012-02-10 2014-12-10 株式会社百奥尼 用于自动分析生物试样的设备以及方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104520711B (zh) 2013-05-30 2017-09-19 秀根科技株式公司 生物物质的实时定量及定性分析方法
CN103484534A (zh) * 2013-06-19 2014-01-01 兰州百源基因技术有限公司 一组用于淋病奈瑟氏菌实时荧光pcr检测的引物和探针及其应用
CN110702933A (zh) * 2013-09-12 2020-01-17 西门子医疗保健诊断公司 动态测定选择和样本制备装置和方法及其机器可读介质
KR20200020997A (ko) * 2015-02-10 2020-02-26 일루미나, 인코포레이티드 세포 성분을 분석하기 위한 방법 및 조성물
KR101707987B1 (ko) * 2015-06-16 2017-02-21 휴스텝스 주식회사 자동 정량 분주기 및 상기 분주기를 포함하는 연속식 유전자 추출-증폭 장비와 연속식 유전자 추출-증폭 방법
US20170270245A1 (en) * 2016-01-11 2017-09-21 Edico Genome, Corp. Bioinformatics systems, apparatuses, and methods for performing secondary and/or tertiary processing
CA3011617A1 (en) * 2016-02-05 2017-08-10 Gen-Probe Incorporated Dried amplification compositions
WO2017154567A1 (ja) * 2016-03-11 2017-09-14 パナソニック株式会社 試料分析方法及び試料分析装置
WO2018074614A1 (ko) * 2016-10-17 2018-04-26 휴스텝스 주식회사 자동 정량 분주기 및 상기 분주기를 포함하는 연속식 유전자 추출-증폭 장비와 연속식 유전자 추출-증폭 방법
US11590495B2 (en) 2017-07-28 2023-02-28 Hewlett-Packard Development Company, L.P. Ionic species interrogation and sensing
EP3690886A4 (en) * 2017-09-28 2021-06-23 Seegene, Inc. AMPLIFICATION DATA DISPLAY METHOD AND DEVICE
CN109825416A (zh) * 2018-11-16 2019-05-31 苏州新波生物技术有限公司 一种全自动分子诊断系统及分子诊断方法
CN114667338A (zh) * 2019-09-20 2022-06-24 美国西门子医学诊断股份有限公司 用于在样品制备期间搅拌流体的改进的转子混合器
CN110951580B (zh) * 2019-09-29 2022-05-20 中国科学院苏州生物医学工程技术研究所 高通量单细胞转录组与基因突变整合分析一体化装置
US20230183784A1 (en) * 2020-05-13 2023-06-15 Ohio State Innovation Foundation Quadruplex-based detection of a target nucleic acid
CN111812131B (zh) * 2020-07-21 2020-12-25 中国科学院地质与地球物理研究所 水合物二次生成或分解过程的可视化试验系统及方法
CN111849758A (zh) * 2020-08-18 2020-10-30 上海基灵生物科技有限公司 全自动实时荧光定量pcr检测系统
KR102581063B1 (ko) * 2020-12-31 2023-09-22 한국기계연구원 고속 온도제어가 가능한 고속 분자진단장치 및 이를 이용한 고속 분자진단방법
JP2022109744A (ja) * 2021-01-15 2022-07-28 シスメックス株式会社 核酸分析方法および核酸分析装置
WO2023018085A1 (ko) * 2021-08-10 2023-02-16 주식회사 루닛 병리 슬라이드 이미지와 관련된 정보를 출력하는 방법 및 장치

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336760A (en) 1989-09-14 1994-08-09 Baxter International Inc. Method and useful apparatus for preparing pharmaceutical compositions
EP0691541A2 (de) 1994-07-07 1996-01-10 Roche Diagnostics GmbH Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln
US5647994A (en) 1993-06-21 1997-07-15 Labsystems Oy Method and apparatus for separating magnetic particles from a solution
US5702590A (en) 1993-05-05 1997-12-30 Dsm N.V. Process for the removal of mercury
KR0148239B1 (ko) 1994-06-15 1998-08-01 히데지 다지마 피펫 기구를 이용한 자성물질의 유인/유리 제어방법 및 이 방법을 이용한 분석장치
US5897783A (en) 1992-09-24 1999-04-27 Amersham International Plc Magnetic separation method
KR100794703B1 (ko) 2003-04-03 2008-01-14 (주)바이오니아 생화학적 반응의 실시간 모니터링 장치
KR20080032904A (ko) 2006-10-11 2008-04-16 삼성전자주식회사 표시패널
KR20080064558A (ko) 2007-01-05 2008-07-09 엘지전자 주식회사 냉장고

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2096198A1 (en) * 1992-06-26 1993-12-27 Christopher J. Macko Automated clinical analyzer with temperature control
JP4281877B2 (ja) * 1996-06-04 2009-06-17 ユニバーシティ オブ ユタ リサーチ ファウンデーション 生物学的プロセスを実行し且つモニタリングするためのシステムと方法
WO1999047267A1 (en) * 1998-03-19 1999-09-23 Precision System Science Co., Ltd. Apparatus for integrating processing of magnetic particles, and method of controlling the same
US6153412A (en) * 1998-12-07 2000-11-28 Bioneer Corporation Lyophilized reagent for polymerase chain reaction
AU3769000A (en) * 1999-03-22 2000-10-09 Pangene Corporation High-throughput gene cloning and phenotypic screening
SG121902A1 (en) * 2000-01-11 2006-05-26 Maxygen Inc Integrated systems for diversity generation and screening
JP2001269160A (ja) * 2000-03-24 2001-10-02 Bioneer Corp 自動核酸精製装置
US20020155587A1 (en) * 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US20040053318A1 (en) * 2002-09-17 2004-03-18 Mcwilliams Diana R. Preservation of RNA and reverse transcriptase during automated liquid handling
BR0316078A (pt) * 2002-11-08 2005-09-27 Pharmacia Corp Métodos automáticos de isolamento e quantificação de ácido nucléico de alta passagem
US20050089875A1 (en) * 2002-11-21 2005-04-28 Sention Inc. Quantitative analysis of expression profiling information produced at various stages of an amplification process
DE102004021822B3 (de) * 2004-04-30 2005-11-17 Siemens Ag Verfahren und Anordnung zur DNA-Amplifikation mittels PCR unter Einsatz von Trockenreagenzien
US20070042354A1 (en) * 2005-08-19 2007-02-22 Engelhard Eric K Detecting pathogens in companion animals
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
US8298763B2 (en) 2007-03-02 2012-10-30 Lawrence Livermore National Security, Llc Automated high-throughput flow-through real-time diagnostic system

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336760A (en) 1989-09-14 1994-08-09 Baxter International Inc. Method and useful apparatus for preparing pharmaceutical compositions
US5897783A (en) 1992-09-24 1999-04-27 Amersham International Plc Magnetic separation method
US5702590A (en) 1993-05-05 1997-12-30 Dsm N.V. Process for the removal of mercury
US5647994A (en) 1993-06-21 1997-07-15 Labsystems Oy Method and apparatus for separating magnetic particles from a solution
KR0148239B1 (ko) 1994-06-15 1998-08-01 히데지 다지마 피펫 기구를 이용한 자성물질의 유인/유리 제어방법 및 이 방법을 이용한 분석장치
EP0691541A2 (de) 1994-07-07 1996-01-10 Roche Diagnostics GmbH Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln
US6187270B1 (en) 1994-07-07 2001-02-13 Roche Diagnostics Gmbh Device and method for the separation of magnetic microparticles
KR100794703B1 (ko) 2003-04-03 2008-01-14 (주)바이오니아 생화학적 반응의 실시간 모니터링 장치
KR20080032904A (ko) 2006-10-11 2008-04-16 삼성전자주식회사 표시패널
KR20080064558A (ko) 2007-01-05 2008-07-09 엘지전자 주식회사 냉장고

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NBIOCHEM. BIOPHYS. RES. COMMUN, vol. 248, 1998, pages 200 - 203
See also references of EP2407557A4

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013541959A (ja) * 2010-10-27 2013-11-21 バイオニア コーポレーション 多様な生体試料分析のための自動リアルタイムｐｃｒシステム
US9850530B2 (en) 2010-10-27 2017-12-26 Bioneer Corporation Automatic real-time PCR system for the various analysis of biological sample
CN104204229A (zh) * 2012-02-10 2014-12-10 株式会社百奥尼 用于自动分析生物试样的设备以及方法
CN104204229B (zh) * 2012-02-10 2016-09-07 株式会社百奥尼 用于自动分析生物试样的设备以及方法

Also Published As

Publication number Publication date
JP5774499B2 (ja) 2015-09-09
CA2755234A1 (en) 2010-09-16
KR20100102560A (ko) 2010-09-24
CN102388148B (zh) 2017-05-17
BRPI1008957B1 (pt) 2020-04-22
CA2755234C (en) 2020-06-30
BRPI1008957B8 (pt) 2021-07-27
WO2010104345A3 (ko) 2011-01-13
CN102388148A (zh) 2012-03-21
RU2532853C2 (ru) 2014-11-10
RU2011141128A (ru) 2013-04-20
EP2407557B1 (en) 2020-05-20
BRPI1008957A2 (pt) 2016-03-15
KR101423936B1 (ko) 2014-07-29
EP2407557A2 (en) 2012-01-18
US20120135394A1 (en) 2012-05-31
EP2407557A4 (en) 2016-05-25
AU2010221905B2 (en) 2015-04-16
AU2010221905A1 (en) 2011-10-06
CL2011002228A1 (es) 2012-03-23
JP2012523820A (ja) 2012-10-11

Similar Documents

Publication Publication Date Title
WO2010104345A3 (ko) 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법
EP4343788A3 (en) Diagnostic methods
WO2016205233A3 (en) Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
EP2752245A3 (en) System Or Method Of Including Analytical Units
RU2014140117A (ru) Дополнительное исследование проб с применением остаточных материалов от предыдущего теста
WO2012024658A3 (en) Integrated analysis system
WO2011017094A3 (en) Assay apparatuses, consumables and methods
EP2179025A4 (en) INTEGRATED APPARATUS FOR PERFORMING NUCLEIC ACID EXTRACTION AND DIAGNOSTIC TESTS ON MULTIPLE BIOLOGICAL SAMPLES
WO2008064067A3 (en) Method for the sequential analysis of different components in a single biological sample and reagents therefor
WO2011087760A3 (en) Processes and kits for identifying aneuploidy
WO2007044974A3 (en) Absolute pcr quantification
WO2010141075A8 (en) Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow
WO2012011660A3 (ko) 시료 내장 마이크로 챔버 플레이트 및 분석용 마이크로 챔버 프레이트의 제조 방법, 분석용 마이크로 챔버 플레이트 및 시료 내장 마이크로 챔버 플레이트 제조 장치 셋
WO2011101728A3 (en) Identification of source of dna samples
BRPI0610092A2 (pt) mÉtodos para a detecÇço de um analito e de um Ácido nucleico em uma amostra, e para sintetizaÇço de uma molÉcula de Ácido nucleico ou de anÁlago de Ácido nucleico, kit reagente, usos do mesmo, de um composto, e de um mÉtodo, molÉcula de Ácido nucleico ou de anÁlogo de Ácido nucleico, produto de metalizaÇço, produto associado, e, composto
WO2013010134A3 (en) Systems, apparatus and methods for biochemical analysis
WO2012125807A3 (en) Systems and compositions for diagnosing barrett's esophagus and methods of using the same
WO2009134452A3 (en) Preterm delivery diagnostic assay
WO2011046614A3 (en) Methods and systems for phylogenetic analysis
WO2013090386A3 (en) Methods and kits for room temperature in situ detection of a target nucleic acid in a biological sample
MX2014006118A (es) Deteccion de analitos.
WO2009123996A3 (en) Hybridization quantitation method for modified micro-rna and -dna based oligonucleotides
WO2009151757A3 (en) Method and apparatus for forensic screening
BR112022011676A2 (pt) Kit para detectar um analito de interesse em uma pluralidade de amostras líquidas biológicas, método para detectá-lo e /ou quantificá-lo e cartucho para realizar tal método
WO2008034968A3 (fr) Procede de mesure quantitative de cibles biomoleculaires deposees sur une biopuce, et dispositif pour sa mise en oeuvre.

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201080011492.4

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10751036

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 1870/MUMNP/2011

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2011002228

Country of ref document: CL

Ref document number: 13255646

Country of ref document: US

Ref document number: 2755234

Country of ref document: CA

Ref document number: 2011553957

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2010221905

Country of ref document: AU

Ref document number: 2011/08927

Country of ref document: TR

Ref document number: 2010751036

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2010221905

Country of ref document: AU

Date of ref document: 20100311

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2011141128

Country of ref document: RU

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: PI1008957

Country of ref document: BR

ENP Entry into the national phase

Ref document number: PI1008957

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20110912