WO2010082649A1 - Recipient double chambre - Google Patents

Recipient double chambre Download PDF

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Publication number
WO2010082649A1
WO2010082649A1 PCT/JP2010/050480 JP2010050480W WO2010082649A1 WO 2010082649 A1 WO2010082649 A1 WO 2010082649A1 JP 2010050480 W JP2010050480 W JP 2010050480W WO 2010082649 A1 WO2010082649 A1 WO 2010082649A1
Authority
WO
WIPO (PCT)
Prior art keywords
opening
discharge port
bag
drug
drug bag
Prior art date
Application number
PCT/JP2010/050480
Other languages
English (en)
Japanese (ja)
Inventor
清水馨
村松康宏
Original Assignee
味の素株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 味の素株式会社 filed Critical 味の素株式会社
Priority to JP2010546664A priority Critical patent/JPWO2010082649A1/ja
Publication of WO2010082649A1 publication Critical patent/WO2010082649A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261—Flexible containers having several compartments
    • B65D81/3266—Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/36—Moulds having means for locating or centering cores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/76—Making non-permanent or releasable joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/345—Progressively making the joint, e.g. starting from the middle
    • B29C66/3452—Making complete joints by combining partial joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/347—General aspects dealing with the joint area or with the area to be joined using particular temperature distributions or gradients; using particular heat distributions or gradients
    • B29C66/3472—General aspects dealing with the joint area or with the area to be joined using particular temperature distributions or gradients; using particular heat distributions or gradients in the plane of the joint, e.g. along the joint line in the plane of the joint or perpendicular to the joint line in the plane of the joint
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
    • B29C66/41—Joining substantially flat articles ; Making flat seams in tubular or hollow articles
    • B29C66/43—Joining a relatively small portion of the surface of said articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/532—Joining single elements to the wall of tubular articles, hollow articles or bars
    • B29C66/5326—Joining single elements to the wall of tubular articles, hollow articles or bars said single elements being substantially flat
    • B29C66/53261—Enclosing tubular articles between substantially flat elements
    • B29C66/53262—Enclosing spouts between the walls of bags, e.g. of medical bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/72—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined
    • B29C66/723—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/914—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux
    • B29C66/9141—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature
    • B29C66/91411—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature of the parts to be joined, e.g. the joining process taking the temperature of the parts to be joined into account
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/919—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/919—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges
    • B29C66/9192—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges in explicit relation to another variable, e.g. temperature diagrams
    • B29C66/91921—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges in explicit relation to another variable, e.g. temperature diagrams in explicit relation to another temperature, e.g. to the softening temperature or softening point, to the thermal degradation temperature or to the ambient temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/21—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being formed by a single dot or dash or by several dots or dashes, i.e. spot joining or spot welding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
    • B29C66/41—Joining substantially flat articles ; Making flat seams in tubular or hollow articles
    • B29C66/43—Joining a relatively small portion of the surface of said articles
    • B29C66/431—Joining the articles to themselves
    • B29C66/4312—Joining the articles to themselves for making flat seams in tubular or hollow articles, e.g. transversal seams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/735—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the extensive physical properties of the parts to be joined
    • B29C66/7352—Thickness, e.g. very thin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29L2031/7148—Blood bags, medical bags

Definitions

  • the present invention comprises a drug bag in which an internal cavity is separated by a weak seal portion, each of which forms a plurality of compartments for separately containing and storing a medicine, and the weak seal portion is opened to open each compartment. More specifically, with respect to the multi-chamber container in which the administration is performed through the discharge port that is opened after the medicines are mixed, it is possible to more reliably prevent an erroneous operation in which the administration is performed without opening the weak seal portion. It relates to a multi-chamber container.
  • a discharge port as a plastic molded product is welded to the outer periphery of the drug bag, the discharge port is formed in a cylindrical shape, and the internal cavity opens to one compartment on one end side.
  • a rubber plug is provided at the other end located outside.
  • the weak seal Prior to administration of the drug solution to the patient, the weak seal is peeled open by pressurizing the drug bag from the outside, and the drug bag has a single internal cavity, so the two types of drug solution are mixed and the infusion set is punctured A rubber stopper is punctured with a needle, and a drug solution can be administered from a drug bag. Therefore, in this type of medical mixed-type multi-chamber container, it is indispensable to mix both liquids by opening the weak seal part prior to administration of the chemical solution, and on the other hand, the liquid is discharged without opening the weak seal part. When the rubber stopper is punctured at the outlet, there is a possibility of an erroneous operation in which only the drug solution in the discharge side compartment is administered. As a conventional technique for coping with this problem, there is known a technique in which an opening / closing member that interlocks with the expansion displacement of the medicine bag when the weak seal portion is opened is provided at the discharge port (Patent Document 1).
  • Patent Document 4 there is a type in which a fragile portion is provided in the discharge port, the fragile portion is caused to break by deformation of the drug bag when the weak seal portion is opened, and the discharge port is opened.
  • the opening / closing member opening operation relies only on the expansion deformation of the drug bag for opening the weak seal. Therefore, in relation to the external force necessary for opening the opening / closing member and the force applied to the drug bag for opening the weak seal, the opening / closing member is opened (discharge of the chemical solution from the discharge portion) only by opening the weak seal.
  • the opening / closing member is opened (discharge of the chemical solution from the discharge portion) only by opening the weak seal.
  • the opening / closing member is connected to the discharge port by the fragile portion for the opening operation of the opening / closing member, and the fragile portion is destroyed by relying on the expansion deformation of the drug bag for opening the weak seal, and the opening / closing member is opened.
  • the fragile portion is destroyed by relying on the expansion deformation of the drug bag for opening the weak seal, and the opening / closing member is opened.
  • the present invention has been made in view of the above problems, and an object of the present invention is to more reliably open and close the opening / closing member by opening a weak seal.
  • the welding is formed by a soft film, and is formed by welding the opposing surfaces of the drug bag so as to be separated by pressure so as to separate the internal cavity into a plurality of compartments for storing the respective drugs.
  • a medicine bag provided with a portion, a discharge opening attached to the medicine bag, an opening for opening the inside of the medicine bag inside the discharge opening for infusion, and a plug attached to the discharge opening so as to face the outside of the medicine bag
  • an opening / closing member that normally opens and closes the opening with respect to the inside of the medicine bag, and an opening / closing member that is connected to the discharge port so as to normally close the opening, and an external force for peeling the welded portion from the outside of the medicine bag.
  • a multi-chamber container including a fragile portion to be destroyed and an elastic member that urges the opening / closing member in an opening direction by an elastic force that does not cause destruction of the fragile portion from the inside.
  • the elastic member may be formed by forming an elastic material into a plate shape, and one end may be in contact with the inner surface of the discharge port and the other end may be in contact with the inner surface of the opening / closing member.
  • the welding is formed by a soft film, and is formed by welding the opposing surfaces of the drug bag so as to be separated by pressure so as to separate the internal cavity into a plurality of compartments for storing the respective drugs.
  • a medicine bag provided with a portion, a discharge opening attached to the medicine bag, an opening for opening the inside of the medicine bag inside the discharge opening for infusion, and a plug attached to the discharge opening so as to face the outside of the medicine bag
  • an opening / closing member that normally opens and closes the opening with respect to the inside of the medicine bag, and an opening / closing member that is connected to the discharge port so as to normally close the opening, and an external force for peeling the welded portion from the outside of the medicine bag.
  • a multi-chamber container having a fragile portion to be broken, the fragile portion having a shape having a discontinuous tip.
  • the discontinuity at the tip of the fragile portion can be formed by the intersection of circles having different centers and outer diameters.
  • the welding is formed of a soft film and is formed by welding the opposing surfaces of the drug bag so as to be pressure-separated so as to separate the internal cavity into a plurality of compartments for storing the respective drugs.
  • a medicine bag provided with a portion, a discharge opening attached to the medicine bag, an opening for opening the inside of the medicine bag inside the discharge opening for infusion, and a plug attached to the discharge opening so as to face the outside of the medicine bag
  • an opening / closing member that normally opens and closes the opening with respect to the inside of the medicine bag, and an opening / closing member that is connected to the discharge port so as to normally close the opening, and an external force for peeling the welded portion from the outside of the medicine bag.
  • a fragile portion to be broken wherein the fragile portion is provided with a multi-chamber container whose thickness varies along the longitudinal direction.
  • the fragile portion may have a corrugated cross-sectional shape along the longitudinal direction, or the fragile portion may have a stepped cross-sectional shape with the tip side lowered along the longitudinal direction. it can.
  • a drug bag provided with a welded portion formed by welding the opposite surfaces of the drug bag so as to be pressure-separated so as to separate the internal cavity into a plurality of compartments for storing the respective drugs.
  • Opening / closing part that is attached to the peripheral part is connected to the extension part to the inside of the drug bag via the weak part, and is opened by breaking the weak part by an external force for peeling the weld part from the outside of the drug bag
  • a cylindrical discharge port molding apparatus with a mold that is divided along the longitudinal center line of the discharge port and a mold that is complementary to the discharge port by being located in the central cavity of the mold Of the molten resin that directly opens from the mold through the core end surface to the fragile portion forming site in addition to the molten resin introduction passage from the outer peripheral surface side to the cavity.
  • a molding device with an introduction passage is provided. It is.
  • the welding is formed of a soft film and is formed by welding the opposing surfaces of the drug bag so as to be separated by pressure so as to separate the internal cavity into a plurality of compartments for storing the respective drugs. Is attached to the peripheral portion of the medicine bag provided with a part, connected to the extension part to the inside of the medicine bag via the weak part, and the weak part is destroyed by an external force for peeling the weld part from the outside of the medicine bag.
  • a cylindrical discharge port molding apparatus having an opening / closing portion opened by a mold, and a mold that is divided along a longitudinal center line of the discharge port and a central cavity of the mold And a core that forms a complementary cavity with the discharge port, and the height of the mold part in the molding part of the fragile part in the cavity varies along the longitudinal direction.
  • a molding apparatus is provided.
  • the shape whose height changes along the longitudinal direction is a corrugated cross-sectional shape along the longitudinal direction, or the shape whose height changes along the longitudinal direction is the tip side along the longitudinal direction. It can be made into the step (step) shape which made low, or a taber shape.
  • the elastic member that urges the opening / closing member from the inside in the opening direction with an elastic force that does not cause destruction of the fragile portion, the opening / closing member opening direction when the fragile portion is broken and broken
  • the elastic member can assist the movement, and the opening / closing member can be reliably opened and the medicine can be surely distributed from the medicine bag to the discharge port.
  • the elastic member can be visually observed from the opening when the opening and closing member is opened, it can be used as an indicator that the opening of the medicine bag has been performed reliably by using the coloring of the elastic member together. It can be useful for prevention. Further, if there is a clogging of the opening at the end of the drip, there is a possibility of residual liquid. However, the presence of an elastic member prevents the opening from being clogged at the end of the drip and has an effect of preventing the residual liquid.
  • the fragile portion is molded so that the tip has a discontinuous portion, thereby breaking the fragile portion due to the opening of the opening and closing member at the connection site of the opening and closing member by opening the weak seal portion.
  • the cross-sectional shape of the fragile portion can be changed in the longitudinal direction to locally form a thin portion on the tip side, and the drug bag at the connection site of the opening / closing member by opening the weak seal portion It is possible to reliably start the breakage of the fragile portion due to the expansion of the region starting from the locally thin portion at the tip, and to reliably link the opening operation of the weak seal portion and the opening operation of the on-off valve.
  • the fragile portion forming portion in the cavity is directly passed from the mold through the core end surface.
  • the height of the mold part in the molding part of the fragile part in the cavity changes along the longitudinal direction,
  • the shrinkage of the product due to cooling after molding is concentrated on the thick part, and the thickness of the thin part can be further reduced due to the sink mark, which leads to the opening operation of the outlet when opening the product when it becomes a product. Further certainty of the interlock can be realized.
  • FIG. 1 is a plan view of a multi-chamber container according to the first embodiment of the present invention.
  • 2 is a partial longitudinal sectional view of the multi-chamber container of FIG. 1 (a sectional view taken along the line II-II of FIG. 1).
  • 3 is a cross-sectional view (a cross-sectional view taken along the line III-III in FIG. 1) of the distal end portion of the discharge port in the multi-chamber container of FIG.
  • FIG. 4 is an enlarged view (tab is shown in an open state) of the distal end portion of the discharge port in the multi-chamber container of FIG.
  • FIG. 5 is an enlarged view of the distal end portion of the discharge port in the multi-chamber container of FIG.
  • FIG. 6 is a schematic cross-sectional view of a molding apparatus (mold and core) for molding a discharge port in a multi-chamber container (the tip of the mold is shown along a broken line along line VI-VI in FIG. 7). Is).
  • FIG. 7 is a partial plan view of the molding apparatus shown in FIG.
  • FIG. 8 is a partial cross-sectional view of a molding apparatus according to another embodiment for molding a discharge port in a multi-chamber container.
  • FIG. 9 is a top view of the distal end portion of the discharge port formed by the forming apparatus of FIG.
  • FIG. 10 is a partial cross-sectional view of a molding apparatus of still another embodiment for molding a discharge port in a multi-chamber container.
  • FIG. 11 is a view showing a front end portion of a discharge port formed by the forming apparatus of FIG.
  • the multi-chamber container is composed of a flat drug bag 10 and a discharge port 12.
  • the drug bag 10 is made of a multilayer soft film such as a polyethylene film or a polypropylene film having a thickness of 200 to 400 microns.
  • the outer periphery is sealed by a strong seal portion 14 formed by being pressed at a high temperature such as 150 ° C., which is sufficiently higher than its softening temperature, and forms a rectangular flat bag as a whole.
  • a suspension hole is formed at the upper end (not shown) of the strong seal portion 14, and the drug bag 10 is suspended and held on the drip stand or the like by this suspension hole to perform an infusion operation such as drip or dialysis.
  • a weak seal portion (peelable weld portion) or partition wall 18 extends across the entire width at an intermediate portion in the length direction of the drug bag 10, and the front and back surfaces of the drug bag 10 are welded by the weak seal portion 18, and the inside of the drug bag 10
  • a partition that divides the cavity into a first compartment 20 on the discharge port 12 side and a second compartment 22 on the suspension hole side is configured.
  • the first compartment 20 is filled with the first chemical solution
  • the second compartment 22 is filled with the second chemical solution.
  • the weak seal portion 18 is formed by pressurizing the front and back layers of the polyethylene film forming the drug bag 10 at a low temperature such as 130 ° C., which is slightly higher than its softening temperature.
  • the strong seal portion 14 is left as it is by pressurizing the drug solution in the drug bag 10 from the outside in the compartments 20 and 22 with the respective drug solutions stored in the first compartment 20 and the second compartment 22.
  • the weak seal portion 18 can be peeled and opened (without peeling), and the first chemical liquid and the second chemical liquid can be mixed.
  • the discharge port (port) 12 is a plastic such as polyethylene, polypropylene, polyolefin, etc., having a rigidity and thickness capable of maintaining its form (in order to obtain adhesion by welding with the drug bag 10, the same plastic material as the drug bag 10) Is preferable).
  • the upper and lower plastic soft film layers constituting the strong seal portion 14 on the outer periphery of the drug bag 10 are welded so as to sandwich the outer periphery of the discharge port 12 at the portion 14 ′ of the discharge port 12. It has a structure that is firmly connected.
  • the discharge port 12 has one end (the lower end in FIG. 1) formed with an enlarged diameter portion 12-1, and this enlarged diameter portion 12-1 has an opening 24 formed on the bottom surface.
  • a rubber plug 26 (the plug body of the present invention) is fitted to the portion 24.
  • a puncture needle (not shown) of the infusion set is punctured into the rubber plug 26.
  • the other end of the discharge port 12 (upper end in FIG. 1) forms an extension 12-2 to the drug bag 10, and this extension 12-2 has a rectangular cross-sectional shape as shown in FIG. As shown, the tip 12A is closed.
  • extension portion 12-2 It is preferable to extend the extension portion 12-2 for a long time because the external force for breaking the thin-walled portion, which will be described later, obtained by swelling of the drug bag when the drug bag is opened is preferable, but the difficulty in forming the thin-walled portion is increased.
  • a length of up to 30 mm is preferred.
  • An integrally formed flap or tab 28 (opening / closing member of the present invention) is formed on the upper wall of the extending portion 12-2. The entire outer periphery of the tab 28 is integrally formed and connected to the remaining portion of the upper wall of the extended portion 12-2 of the discharge port 12 via the thin portion 30 (fragile portion of the present invention). Accordingly, the tab 28 normally completely blocks (closes) the communication between the internal cavity (lower compartment 20) of the drug bag 10 and the internal passage 12 'of the discharge port 12.
  • the upper surface of the tab 28 and the lower surface of the extended portion 12-2 of the discharge port 12 facing the tab 28 are firmly welded to the opposed inner surface of the plastic film constituting the drug bag 10.
  • the part of the plastic film welded to the tab 28 is represented by 32
  • the part of the plastic film welded to the extension 12-2 is represented by 34.
  • the welding temperature at the portions 32 and 34 is about the same as the welding of the strong seal portion 14 and about 150 ° C. in the case of polyethylene. Therefore, the tab 28 does not peel off from the medicine bag 10 when the weak bag 18 swells when the weak seal 18 for mixing the medicines in the compartments 20 and 22 is peeled off, and is displaced in conjunction with the expansion displacement of the medicine bag. To do.
  • the thin part 30 is weak, it cannot endure the external force at the time of an expansion displacement, and the thin part 30 is fractured
  • a so-called point seal device can be used as means for welding the tab 28 to the facing surface of the drug bag 10 at the portions 32 and 34.
  • the point seal device includes a pair of welding tools conforming to the shapes of the welding parts 32 and 34, and the upper surface of the tab 28 which is the welding part of the plastic film section and the discharge port 12 constituting the medicine bag by the welding tools and the extension.
  • the plastic film section, the tab 28, and the extending portion 12-2 constituting the medicine bag are point-sealed by the high temperature of the welding tool by sandwiching the lower surface of the protruding portion 12-2.
  • the width of the drug bag internal extension portion 12-2 of the discharge port 12 is preferably about 7.0 mm because if it is too narrow, the welding area becomes too small to obtain the required strength.
  • the lower wall surface of the extended portion 12-2 of the discharge port 12 is provided with a small hole 36, which is useful for wet heat sterilization of the medicine bag 10. is there. That is, in the state where the discharge port 12 (the tab 28 is in a closed state because the thin-walled portion 30 is not broken) and the weak seal portion 18 is formed with respect to the drug bag 10, Fill and seal the filling part. In this state, the welded portion 32 and the collar 34 are not formed, so the inside of the medicine bag (the lower compartment 20) communicates with the internal passage 12 'of the discharge port 12 through the small hole 36.
  • the infusion vapor is introduced into the discharge port 12 through the small holes 36, so that the discharge port 12 can be sterilized under wet heat. become.
  • the welded portion 32 and the flange 34 are formed, and the small hole 36 is closed as shown in FIG.
  • FIG. 5 is an enlarged view of the distal end portion of the upper wall surface of the extended portion 12-2 of the discharge port 12 provided with the tab 28.
  • FIG. The thin portion 30 on the outer periphery of the tab 28 has a rounded tip shape that protrudes toward the inside of the drug bag, but the tip portion 30-1 of the thin portion 30 constitutes a discontinuous portion.
  • the thin-walled portion 30 may be broken depending on the situation at the time of opening. Cases that are unlikely to occur can be envisaged.
  • the tip portion 30-1 By forming the tip portion 30-1 discontinuously, the thin-walled portion 30 causes stress concentration in this portion, and positively starts fracture at the tip portion 30-1 where the moment due to the external force applied to the tab 28 is maximized. Promptly and a reliable breaking operation can be expected. That is, if the tip portion 30-1 breaks, the break can be propagated along the thin-walled portion 30 based on this, and a more reliable opening operation can be expected. In the embodiment of FIG.
  • one side of the distal end portion of the thin portion 30 is constituted by inner and outer concentric circles C1 and C1 ′ on the center O1 on the center line in the width direction of the extending portion 12-2 of the discharge port 12, and the other side.
  • the side is constituted by inner and outer concentric circles C2 and C2 'on the center O2 offset from the center O1. Therefore, a discontinuous portion can be formed in the thin portion 30 at the tip 30-1 where the concentric circles C1 and C1 ′ on one side and the concentric circles C2 and C2 ′ on the other side are joined.
  • a spring 40 (an elastic member of the present invention) is installed in the discharge port 12 to assist the reliable opening of the tab 28 when the drug bag 10 is opened.
  • the spring 40 is composed of a strip of metal or the like (see also FIG. 1 for its shape), one end 40-1 positioned at the enlarged diameter portion 12-1, and the other end 12-2 forming a J-shaped bent portion. is doing. 2 where the tab 28 is in the closed position because the drug bag is not opened, the bent portion 40-2 is bent from the original shape shown by the solid line in FIG. 4 (two-dot line 40-2 in FIG. 4).
  • FIG. 4 shows a state in which the tip of the spring 40 is expanded by an elastic force from the contracted state 12-27 when the tab 28 is closed.
  • the outer end 40-1 is bonded to the bottom wall surface of the discharge port 12 as a mounting method of the spring 40 inside the discharge port 12, but the discharge port is used instead of the bonding method. It is also possible to adopt a method in which a groove is formed in the bottom wall surface of the twelve and a spring 40 is fitted and locked in this groove so as to be attached without bonding.
  • the material of the spring 40 may be a plastic strip, and the color of the spring 40 is conspicuous so that the tab 28 is opened from the color when the tab 28 is opened. It can serve as a means for visually notifying the completion of the drug mixing operation between the two.
  • the tab 28 In normal times (when the weak seal portion is not opened), the tab 28 is in the state of FIG. 2 welded to the opposing inner surface of the drug bag 10 by the point seal portion 32. In this state, the tab 28 is integrated with the discharge port 12 by the thin portion 30, and the internal passage 12 ′ of the discharge port 12 is closed with respect to the internal cavity of the drug bag 10. And even if the rubber plug 26 is punctured with the puncture needle of the infusion set, the medicine cannot be discharged, and this helps to prevent an erroneous operation in which the infusion is performed in a state where the medicine between the compartments 20 and 22 is not mixed. be able to. Further, if the opening 35 is closed at the end of the drip, there is a possibility of residual liquid. However, the presence of the spring 40 prevents the opening 35 from being closed at the end of the drip and prevents the residual liquid. .
  • the weak seal portion 18 is opened by placing the drug bag 10 flat on a desk or the like and pressurizing the infusion solution in the drug bag 10 (which may be either the infusion solution in the compartments 20 or 22) with the palm of the hand. Is called. That is, both layers of the drug bag 10 are separated at the weak seal portion 18 by the pressure of the drug solution applied by pressurization, the compartments 20 and 22 are communicated, and the drug solutions that have been separated and accommodated in the compartments 20 and 22 are mixed. Is done.
  • the weak seal portion 18 is opened, the medicine bag 10 is expanded and deformed as shown in FIG. 4 at the connection portion with the discharge port 12, and the tab 28 firmly connected to the opposite surface of the medicine bag by the point seal portion 32 is formed on the medicine bag.
  • the expansion bias is applied, and the thin portion 30 is broken under the external force, and the tab 28 is rotated as shown in FIG.
  • the passage 12 ′ communicates with the internal cavity of the drug bag 10, the mixed medicine is introduced from the drug bag 10 into the internal passage 12 ′ of the discharge port 12, and a puncture needle of an infusion set is punctured into the rubber stopper 26 to perform infusion. be able to.
  • a puncture needle of an infusion set is punctured into the rubber stopper 26 to perform infusion.
  • FIG. 6 shows a mold for molding the discharge port 12 of FIG. 2 is formed between the upper and lower split molds 41 and 42 and the core 44, and a cavity 46 having a shape complementary to the discharge port 12 of FIG.
  • the split surfaces D of the upper and lower split molds 41 and ridges 42 are positioned along the longitudinal center line of the discharge port 12, and the product can be ejected by separating the split molds after molding.
  • the core 44 is held at one end 44-1 (molded portion of the discharge port 12 on the enlarged diameter portion 12-1 side) and between the upper and lower split molds 41 and 42, but the other end (extension of the discharge port 12)
  • the molded part at the front end side of the portion 12-2 is basically free, that is, the core 44 is cantilevered.
  • a protruding portion 41-1 with respect to the core 44 in the upper split mold 41 is a molding portion of the thin portion 30 on the outer periphery of the tab 28 on the upper surface of the drug bag extension portion 12-2 of the discharge port 12.
  • the small-diameter protrusion 42-1 between the lower mold 42 and the core 44 is a molding part of the sterilization small hole 36 on the lower surface of the medicine bag extension 12-2 of the discharge port.
  • a molten resin injection gate 48 is provided on the upper and lower split molds 41 and 42 as usual. The molten resin from the injection gate 48 is basically injected into the cavity 46 from the side surface, but the core 44 is cantilevered and the path is narrowed at the protruding portion 41-1. Due to the flow resistance, the free end 44-2 side of the core 44 is easily displaced downward in FIG. 6, so that the interval between the protruding portion 41-1 and the core 44 is widened.
  • the auxiliary injection gate 50 is formed so as to open at a portion of the cavity 46 facing the end surface 44 ⁇ / b> A of the core 44.
  • a tapered auxiliary injection hole 54 is formed in the core 44, a reduced diameter portion at one end of the injection hole 54 opens into the upper mold projecting portion 41-1, and a larger diameter portion at the other end is the end surface of the core. The diameter is expanded on the side.
  • the injection hole 54 provided at the tip of the core 44 is directly open to the projecting portion 41-1 which is a molding portion of the thin portion, the molten resin is injected into this portion without resistance. Since the portion is immediately filled, the deflection of the tip of the core 44 during molding is eliminated, and the thickness of the thin portion can be set to a desired value.
  • part corresponding to the injection hole 54 remains after shaping
  • FIG. 8 shows another embodiment of the mold structure for setting the thickness of the thin wall portion as expected in order to surely open the flap when the medicine bag is opened.
  • the surface of the thin part 141-1 of the upper split mold 141 facing the core 144 has an uneven shape.
  • the tip shape of the discharge port 112 formed by this forming apparatus is shown in FIG. 9, and the tab 128 on the upper wall surface of the discharge bag 112 extending portion 112-2 of the discharge port 112 is formed in the drug bag by a thin portion 132 as a fragile portion. It is the same that it is integrally generated in the remaining part of the extension part 112-2.
  • the thin portion 132 has an uneven surface on the top surface.
  • the cooling of the resin after mold molding has a large shrinkage (so-called sink) of the thick part, so that the thick part tensions the thin part, so that the thin part becomes thinner, and therefore due to external force at the time of opening the drug bag
  • the thin portion 132 as the fragile portion can be more reliably destroyed.
  • FIG. 10 shows still another embodiment of the mold structure for setting the thickness of the thin wall portion as desired in order to surely open the flap when the medicine bag is opened.
  • the molding part 241-1 of the thin part in the upper split mold 241 has a step shape with the surface facing the core 244 having a lower height toward the tip.
  • the discharge port 112 molded by this molding apparatus is shown in FIG. 11, and the tab 228 on the upper wall surface of the drug bag extension portion 212-2 of the discharge port 212 is extended by the thin portion 232 as a weak portion. It is the same that it is generated integrally in the remaining part of 212-2.
  • the thin-walled portion 232 has a step shape whose upper surface has a lower height at the tip.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un récipient double chambre de type mélange de deux liquides, configuré de sorte qu'une ouverture d'évacuation s'ouvre en réponse à l'ouverture d'une paroi de séparation, l'ouverture d'évacuation étant conçue pour s'ouvrir de façon plus fiable lorsque la paroi de séparation est ouverte. L'ouverture d'évacuation (12) d'un produit formé en résine synthétique est pourvue d'une languette (28) servant de partie d'ouverture/fermeture et elle est située au niveau de la surface de paroi supérieure d'une partie extension (12-2) s'étendant vers l'intérieur d'une poche de médicament. Le périmètre extérieur de la languette (28) est, avec la partie restante de l'ouverture d'évacuation (12), solidaire d'une partie à parois minces (30) servant de partie faible. Un ressort (40) est placé dans l'ouverture d'évacuation (12) et, lorsque ladite ouverture (12) se trouve dans un état fermé, ce ressort (40) est dans un état contracté dans lequel il applique sur la languette (28) une force élastique s'exerçant dans le sens de l'ouverture. La partie à parois minces (30) est rompue par le gonflement de la poche de médicament se produisant lors du mélange des deux liquides, ce qui entraîne l'ouverture de la languette (28) et le passage d'un médicament contenu dans la poche dans l'ouverture d'évacuation (12). La force élastique du ressort (40) favorise la rupture de la partie à parois minces (30).
PCT/JP2010/050480 2009-01-19 2010-01-18 Recipient double chambre WO2010082649A1 (fr)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012135433A (ja) * 2010-12-27 2012-07-19 Terumo Corp 医療用容器用中空体、医療用容器用排出ポート、医療用容器用薬剤容器および医療用容器
JP2017060542A (ja) * 2015-09-24 2017-03-30 株式会社大協精工 ポート付き栓体
WO2017183713A1 (fr) * 2016-04-21 2017-10-26 大和製罐株式会社 Contenant pour seringue
WO2018064263A1 (fr) * 2016-09-29 2018-04-05 Cryovac, Inc. Poche iv à chambres multiples et son procédé de production

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006087904A (ja) * 2004-08-25 2006-04-06 Terumo Corp 医療用容器用筒状体、医療用容器用薬剤容器、医療用容器用排出ポートおよび医療用容器
WO2008136452A1 (fr) * 2007-04-27 2008-11-13 Ajinomoto Co., Inc. Contenant à double cellule

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006087904A (ja) * 2004-08-25 2006-04-06 Terumo Corp 医療用容器用筒状体、医療用容器用薬剤容器、医療用容器用排出ポートおよび医療用容器
WO2008136452A1 (fr) * 2007-04-27 2008-11-13 Ajinomoto Co., Inc. Contenant à double cellule

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012135433A (ja) * 2010-12-27 2012-07-19 Terumo Corp 医療用容器用中空体、医療用容器用排出ポート、医療用容器用薬剤容器および医療用容器
JP2017060542A (ja) * 2015-09-24 2017-03-30 株式会社大協精工 ポート付き栓体
WO2017183713A1 (fr) * 2016-04-21 2017-10-26 大和製罐株式会社 Contenant pour seringue
JP2017192584A (ja) * 2016-04-21 2017-10-26 大和製罐株式会社 注射器用容器
WO2018064263A1 (fr) * 2016-09-29 2018-04-05 Cryovac, Inc. Poche iv à chambres multiples et son procédé de production

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JPWO2010082649A1 (ja) 2012-07-05

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