TW201040083A - Multi-chamber container - Google Patents

Multi-chamber container Download PDF

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Publication number
TW201040083A
TW201040083A TW99100692A TW99100692A TW201040083A TW 201040083 A TW201040083 A TW 201040083A TW 99100692 A TW99100692 A TW 99100692A TW 99100692 A TW99100692 A TW 99100692A TW 201040083 A TW201040083 A TW 201040083A
Authority
TW
Taiwan
Prior art keywords
discharge port
opening
bag
drug bag
drug
Prior art date
Application number
TW99100692A
Other languages
Chinese (zh)
Inventor
Kaoru Shimizu
Yasuhiro Muramatsu
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of TW201040083A publication Critical patent/TW201040083A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261—Flexible containers having several compartments
    • B65D81/3266—Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/36—Moulds having means for locating or centering cores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/76—Making non-permanent or releasable joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/345—Progressively making the joint, e.g. starting from the middle
    • B29C66/3452—Making complete joints by combining partial joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/347—General aspects dealing with the joint area or with the area to be joined using particular temperature distributions or gradients; using particular heat distributions or gradients
    • B29C66/3472—General aspects dealing with the joint area or with the area to be joined using particular temperature distributions or gradients; using particular heat distributions or gradients in the plane of the joint, e.g. along the joint line in the plane of the joint or perpendicular to the joint line in the plane of the joint
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
    • B29C66/41—Joining substantially flat articles ; Making flat seams in tubular or hollow articles
    • B29C66/43—Joining a relatively small portion of the surface of said articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/532—Joining single elements to the wall of tubular articles, hollow articles or bars
    • B29C66/5326—Joining single elements to the wall of tubular articles, hollow articles or bars said single elements being substantially flat
    • B29C66/53261—Enclosing tubular articles between substantially flat elements
    • B29C66/53262—Enclosing spouts between the walls of bags, e.g. of medical bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/72—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined
    • B29C66/723—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/914—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux
    • B29C66/9141—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature
    • B29C66/91411—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature of the parts to be joined, e.g. the joining process taking the temperature of the parts to be joined into account
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/919—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/919—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges
    • B29C66/9192—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges in explicit relation to another variable, e.g. temperature diagrams
    • B29C66/91921—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges in explicit relation to another variable, e.g. temperature diagrams in explicit relation to another temperature, e.g. to the softening temperature or softening point, to the thermal degradation temperature or to the ambient temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/21—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being formed by a single dot or dash or by several dots or dashes, i.e. spot joining or spot welding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
    • B29C66/41—Joining substantially flat articles ; Making flat seams in tubular or hollow articles
    • B29C66/43—Joining a relatively small portion of the surface of said articles
    • B29C66/431—Joining the articles to themselves
    • B29C66/4312—Joining the articles to themselves for making flat seams in tubular or hollow articles, e.g. transversal seams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/735—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the extensive physical properties of the parts to be joined
    • B29C66/7352—Thickness, e.g. very thin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/04—Polymers of ethylene
    • B29K2023/06—PE, i.e. polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/10—Polymers of propylene
    • B29K2023/12—PP, i.e. polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7148—Blood bags, medical bags

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A dual-chamber container of two-liquid mixing type, configured so that a discharge opening is opened in response to opening of a partition wall, wherein the discharge opening is adapted to be more reliably opened when the partition wall is opened. A discharge opening (12) of a synthetic resin formed product is provided with a tab (28) which serves as an opening/closing section and is located at the upper wall surface of an extension section (12-2) extended to the inside of a medication bag. The outer periphery of the tab (28) is, together with the remaining portion of the discharge opening (12), formed integrally with a thin-walled section (30) which serves as a weak section. A spring (40) is disposed within the discharge opening (12), and when the discharge opening (12) is in a closed state, the spring (40) is in a contracted state in which the spring applies to the tab (28) elastic force acting in the opening direction. The thin-walled section (30) is broken by inflation of the medication bag occurring when two liquid are mixed, and this opens the tab (28) to cause a medication in the medication bag to be introduced into the discharge opening (12). The elastic force of the spring (40) promotes the breakage of the thin-walled section (30).

Description

201040083 六、發明說明： 【發明所屬之技術領域】 該發明是關於多室容器，由藉由以弱密封部將內部空 洞分離，而形成了分別將各個藥劑密封收容的複數的隔室 的藥劑袋所構成，藉由弱密封部的開通而將來自各個隔室 的藥劑混合之後，從打開的排出口進行投藥；更詳細來說 ’是關於多室容器，要更確實地防止在弱密封部尙未開通 〇 就進行投藥這樣的錯誤操作。 【先前技術】 作爲輸送液多室容器，藉由將以軟質薄膜爲材料的藥 劑袋的相對面相對地以低溫熔接而成的弱密封部（隔壁） ，分離成分別收容不同的藥液的複數的隔室。在藥劑袋的 外周，熔接著作爲塑膠成型件的排出口（口部），排出口 形成爲筒狀’其內部空洞部在一端側開口於其中一方的隔 Ο 室’在位於藥劑袋外側的另一端設置有橡膠栓。在對患者 進行藥液的投藥之前，藉由將藥劑袋從外側加壓來使弱密 封部剝離開通’則藥劑袋的內部空洞部會成爲一個腔室而 將兩種藥液混合’藉由輸送液套件的穿刺針來穿刺橡膠栓 ，則可利用藥劑袋進行藥液的投藥。於是，這種醫療用混 合型多室容器’在進行藥液的投藥之前，必須進行利用弱 密封部的開通而將兩液混合的作業，另一方面，如果沒有 進行弱密封部的開通就進行排出口的橡膠栓的穿刺的話， 可能會錯誤操作只將排出口側的隔室的藥液進行投藥。作 -5- 201040083 爲對應這種問題點的已知先前技術，是在排出口設置有： 與弱密封部開通時的藥劑袋的擴張移位連動的開閉構件（ 專利文獻1 )。 爲了解決在弱密封部尙未開通就進行輸送液作業這樣 同樣的問題，也提出過：在排出口之前，設置有：稍微提 高熔接溫度而較隔室間的弱密封部的開通更慢開通的第二 弱密封部的技術（專利文獻2及3 )。 而也有在排出口設置脆弱部，藉由弱密封部的開通時 的藥劑袋的變形而引起脆弱部的破壞，使排出口開□的技 術（專利文獻4 )。 [專利文獻1] 日本特開2006— 8 7904號公報 [專利文獻2] 日本特開平9—32 74 98號公報 [專利文獻3] 日本特開2006— 507914號公報 [專利文獻4] 日本特開2006 — 507914號公報 【發明內容】 -6- 201040083 [發明欲解決的課題] 在習知技術，是將開閉構件的開放動作依賴於用來使 弱密封部開通的藥劑袋的擴張變形。因此’在開閉構件的 開放動作所需要的外部力、以及弱密封部開通用的施加於 藥劑袋的力量的關係，只有弱密封部的開通’無法進行開 閉構件的開通（藥液從排出部的排出）。 由於開閉構件的開放動作’藉由脆弱部將開閉構件相 〇 對於排出口連結，依賴弱密封部開通用的藥劑袋的擴張變 形將脆弱部破壞，而達成開閉構件的開通，可是問題是很 難將排出口的成型時的脆弱部控制爲預期的厚度，而成爲 成型步驟上的瓶頸。 並且由於將脆弱部的破壞及伴隨產生的開閉構件的開 放動作依賴於藥劑袋的擴張變形，所以問題是用來破壞脆 弱部的外力大小不一定如預期，當弱密封部開通時，脆弱 部的破壞也不一定都是順暢開始進行。 〇 本發明鑑於以上的問題，其目的是要更確實地進行： 利用弱密封部開通所達成的開閉構件的開放。 [用以解決課題的手段] 藉由第1發明’本發明要提供一種多室容器，是具備 有：以軟質薄膜形成·’爲了將內部空洞部分別分離成用來 收納藥劑的複數的隔室’而具備有可加壓剝離地熔接藥劑 袋的相對向面所構成的熔接部的藥劑袋、安裝於藥劑袋的 排出口、使藥劑袋內部開口於輸送液用的排出口內部的開 201040083 口部、面對藥劑袋外部地安裝於排出口的栓體、平常將上 述開口部對於藥劑袋內部進行開閉的開閉構件、爲了平常 封閉開口部而將開閉構件連結於排出口，藉由來自藥劑袋 外部的用來剝離熔接部的外力而破壞的脆弱部、以及從內 側以不致於破壞脆弱部的彈力，將開閉構件朝開放方向彈 壓的彈性構件。 在第1發明，彈性構件是將彈性材作成板狀所形成， 其中一端抵接於排出口的內面，另一端抵接於開閉構件的 內面。 藉由第2發明，本發明要提供一種多室容器，是具備 有：以軟質薄膜形成，爲了將內部空洞部分別分離成用來 收納藥劑的複數的隔室，而具備有可加壓剝離地熔接藥劑 袋的相對向面所構成的熔接部的藥劑袋、安裝於藥劑袋的 排出口、使藥劑袋內部開口於輸送液用的排出口內部的開 口部、面對藥劑袋外部地安裝於排出口的栓體、平常將上 述開口部對於藥劑袋內部進行開閉的開閉構件、爲了平常 封閉開口部而將開閉構件連結於排出口，藉由來自藥劑袋 外部的用來剝離熔接部的外力而破壞的脆弱部；上述脆弱 部作成前端具有不連續部的形狀。 在第2發明，脆弱部的前端的不連續部，能藉由中心 及外徑不同的圓的交叉來形成。 ‘ 藉由第3發明，本發明要提供一種多室容器，是具備 有：以軟質薄膜形成，爲了將內部空洞部分別分離成用來 收納藥劑的複數的隔室，而具備有可加壓剝離地熔接藥劑 -8- 201040083 袋的相對向面所構成的熔接部的藥劑袋、安裝於藥劑袋的 排出口、使藥劑袋內部開口於輸送液用的排出口內部的開 口部、面對藥劑袋外部地安裝於排出口的栓體、平常將上 述開口部對於藥劑袋內部進行開閉的開閉構件、爲了平常 封閉開口部而將開閉構件連結於排出口，藉由來自藥劑袋 外部的用來剝離熔接部的外力而破壞的脆弱部；上述脆弱 部其厚度沿著長軸方向變化。 Ο 在第3發明，脆弱部可作成沿著長軸方向波浪形的剖 面形狀，或者脆弱部可作成沿著長軸方向而前端側降低的 階段狀的剖面形狀。 藉由第4發明，要提供一種筒狀的排出口的成型裝置 ， 該筒狀的排出口安裝在藥劑袋的周緣部：該藥劑袋， 以軟質薄膜形成，爲了將內部空洞部分別分離成用來收納 藥劑的複數的隔室，而具備有可加壓剝離地熔接藥劑袋的 相對向面所構成的熔接部·，該筒狀的排出口具備有開閉部 Ο ，該開閉部，隔介著脆弱部連接到朝藥劑袋內部的延伸部 ，且利用來自藥劑袋外部的用來剝離熔接部的外力來破壞 脆弱部而開口，其特徵爲：具備有：沿著排出口的長軸方 向中心線分割的模具、與藉由位於模具的中心空洞，而在 模具來與排出口輔助地形成模腔的型芯；且具備有：朝模 腔的來自外周面側的熔融樹脂的導入通路、以及從模具經 由型芯端面直接開口於模腔的脆弱部形成部位的熔融樹脂 的導入通路。 藉由第5發明，要提供一種筒狀的排出口的成型裝置 -9 - 201040083 ’該筒狀的排出口安裝在藥劑袋的周緣部：該藥劑袋，以 軟質薄膜形成’爲了將內部空洞部分別分離成用來收納藥 劑的複數的隔室，而具備有可加壓剝離地溶接藥劑袋的相 對向面所構成的熔接部；該筒狀的排出口具備有開閉部， 該開閉部’隔介著脆弱部連接到朝藥劑袋內部的延伸部， 且利用來自藥劑袋外部的用來剝離熔接部的外力來破壞脆 弱部而開口，其特徵爲：具備有：沿著排出口的長軸方向 中心線分割的模具、與藉由位於模具的中心空洞，而在模 具來與排出口輔助地形成模腔的型芯；模腔的脆弱部的成 型部位的模具的部位，朝向型芯的高度是沿著長軸方向變 化。 在第5發明，高度沿著長軸方向變化的形狀，是作成 沿著長軸方向波浪狀的剖面形狀，或者高度沿著長軸方向 變化的形狀，作成沿著長軸方向而前端側變低的階段形狀 或斜坡形狀。 [發明效果] 藉由第1發明，藉由設置：從內側以不致於破壞脆弱 部的彈力將開閉構件朝開放方向彈壓的彈性構件，藉由彈 性構件可以幫助脆弱部的破壞以及破壞時的開閉構件的開 放方向的動向，可以讓開閉構件確實開放，且使藥劑從藥 劑袋朝向排出口確實流通。而當開閉構件開放時，可以從 開口部目視到彈性構件，所以藉由合倂利用彈性構件的著 色等，可作爲藥劑袋確實開通的指標，能夠防止錯誤操作 -10- 201040083 。而當點滴完成時’如果開口部有封閉情形的話，則會有 液體殘留的可能性，而藉由具有彈性構件，則點滴完成時 開口部不會封閉，會有防止液體殘留的效果。 藉由第2發明’藉由將脆弱部形成爲前端具有不連續 部，來將前端的不連續部作爲基準點而確實開始：利用弱 密封部的開通而進行在開閉構件的連接部位的藥劑袋的擴 張所達成的脆弱部的破壞，而能使弱密封部的開通操作與 Ο 開閉閥的開放動作確實連動。 藉由第3發明，使脆弱部的剖面形狀在長軸方向變化 ，可以在前端側局部形成較薄部分，而可以將前端的局部 較薄部作爲基準點而確實開始：利用弱密封部的開通而進 行在開閉構件的連接部位的藥劑袋的擴張所達成的脆弱部 的破壞，而能使弱密封部的開通操作與開閉閥的開放動作 確實連動。 藉由第4發明，在排出口的成型用的成型裝置，藉由 Ο 具備有··朝向模腔的來自外周面側的熔融樹脂的導入通路 、以及從模具經由型芯端面而直接開口於模腔的脆弱部形 成部位的熔融樹脂的導入通路；成型時可以直接將樹脂充 塡到排出口的脆弱部形成部位，而可以防止成型步驟中的 型芯前端的移位，而防止脆弱部因爲型芯的偏差而變厚’ 而能確實成型爲預期的厚度。 藉由第5發明，在排出口的成型用的成型裝置’模腔 的脆弱部的成型.部位的模具的部位’其朝向型芯的高度是 沿著長軸方向變化’所以使成型後的冷卻導致的製品的收 -11 - 201040083 縮情形集中在較厚部，藉由所導致的收縮情形可以更縮減 較薄部的厚度，可以讓成爲製品時的開通操作時的朝排出 口的開口動作的連動更確實。 【實施方式】 在第1圖及第2圖，多室容器是由：平坦狀的藥劑袋10 '與排出口 12所構成。藥劑袋1〇是將厚度200〜400微米的 聚乙烯或聚丙烯等的多層軟質薄膜作爲材料。在用聚乙烯 薄膜的情況’其外周是以強密封部1 4封住，該強密封部1 4 是以較該薄膜的軟化溫度更高很多的150t這樣的高溫而 加壓所形成’全體作成矩形的平坦袋狀。在強密封部丨4的 沒有圖示的上端穿設有懸吊孔，藉由該懸吊孔將藥劑袋1〇 懸吊保持於點滴台等’進行點滴或透析等的液體輸送作業 〇 在藥劑袋1 0的長度方向的中間部位，涵蓋全寬度延伸 有弱密封部（可剝離熔接部）或隔壁1 8，藉由弱密封部1 8 熔接著藥劑袋1 0的表背面，構成了：將藥劑袋〗〇的內部空 洞部區劃成：排出口 1 2側的第一隔室20、與懸吊孔側的第 二隔室22的隔壁。在第一隔室20充塡第—藥液，在第二隔 室22充塡第二藥液。弱密封部18是藉由··將形成藥劑袋1〇 的聚乙烯薄膜的表背層’以較其軟化溫度稍高的l3〇r這 樣的低溫加壓所形成。因此，在將各個藥液收容於第一隔 室20與第二隔室22的狀態，在隔室20、22的部位，藉由從 外側加壓藥劑袋1 〇的藥液，則強密封部丨4保持原狀（不會 -12- 201040083 剝離）’使弱密封部1 8剝離、開通，而能進行第一藥液與 第二藥液的混合。 排出口（口部2，是具有能維持其型態的剛性的厚 度的聚乙嫌或聚丙烯、聚烯烴等的塑膠（爲了得到與藥劑 袋1 〇的熔接達成的緊貼性，最好是與藥劑袋i 〇同種的塑膠 材料）的成型件。藥劑袋1〇的外周的構成強密封部14的上 下塑膠軟質薄膜層，在排出口 12的部位14，，熔接成夾著 〇 排出口 12的外周，藉此，排出口 12成爲與藥劑袋10堅固連 接的構造。 如第2圖所示’排出口 12其中一端（第1圖的下端）形 成擴徑部1 2 — 1 ’該擴徑部1 2 — 1在底面形成開口部2 4，在 該開口部24嵌裝著橡膠栓26(該發明的栓體）。如習知方 式’在輸送液體時，將輸送液套件的穿剌針（沒有圖示） 穿刺到橡膠栓26。排出口 12的另一端（第1圖的上端）形 成了朝藥劑袋10的延伸部12— 2，該延伸部12— 2如第3圖 〇 所不作成矩形剖面形狀，如第1圖所不，前端1 2 A關閉。藉 由將延伸部1 2 — 2長長地延伸，則當藥劑袋開通時的藉由 藥劑袋膨脹所得到的用來破壞後述薄片部的外力變大，可 是薄片部的成型難度會變高所以2〇〜3 0mm這樣的長度較 佳。在延伸部12 — 2的上壁形成有：一體成型的擋板或翼 片28 (該發明的開閉構件）。翼片28的整個外周是隔介著 薄片部30(該發明的脆弱部）而一體地成型連結於排出口 12的延伸部12 — 2的上壁的剩餘部位。於是，翼片28平常 會完全阻止（封閉）藥劑袋1 0的內部空洞部（下側隔室2 0 -13- 201040083 )與排出口 12的內部通路12’的連通。 如第2圖所示，翼片28的上面、以及與翼片28相對向 的排出口 1 2的延伸部1 2 — 2的下面，堅固地熔接於：構成 藥劑袋10的塑膠薄膜的相對向內面。以32來表示熔接於翼 片2 8的塑膠薄膜的部位，以3 4表示熔接於延伸部1 2 — 2的 塑膠薄膜的部位。作爲部位32、34的熔接溫度，是以與強 密封部14的熔接相同程度的溫度，聚乙烯的情況是150°C 左右。因此，當爲了混合隔室20、22的藥劑而當弱密封部 18剝離時的藥劑袋的膨脹時，翼片28不會從藥劑袋1〇剝離 而與藥劑袋的擴張移位連動移位。由於薄片部3 0很脆弱， 所以承受不住擴張移位時的外力，薄片部3 0至少一部分（ 大多是前端部）會破裂，翼片28從第2圖的封閉狀態起， 如第4圖所示以外力較弱而難破壞的根部的部位爲中心轉 動，在排出口 12的延伸部12 — 2的上面，形成有：使排出 口 1 2的內部通路1 2 ’連通到藥劑袋內部的開口部3 5。作爲 部位32、34的翼片28對於藥劑袋10的相對向面的熔接手段 ，能採用所謂的點密封裝置。也就是說，點密封裝置，具 備有比照熔接部32、34的形狀的一對熔接件，藉由熔接件 ，將構成藥劑袋的塑膠薄膜切片、與排出口 1 2的被熔接部 也就是翼片2 8的上面及延伸部1 2 — 2的下面夾住，藉由溶 接件的高溫，將構成藥劑袋的塑膠薄膜切片、與翼片2 8及 延伸部1 2 — 2點密封。而作爲排出口 1 2的藥劑袋內部延伸 部1 2 — 2的寬度，太狹窄的話熔接面積會變得太小，而無 法得到所需要的強度，所以7 · 0mm左右較佳。 -14- 201040083 如第2圖及第4圖所示，排出口 l2的延伸部ι2_2的下 壁面穿設有小孔3 6，該小孔3 6是用來達到對藥劑袋丨〇的濕 熱殺菌。也就是說，在對於藥劑袋10安裝有排出Ql2(薄 片部30未破壞所以翼片28爲封閉狀態）且形成有弱密封部 18的狀態，對隔室20、22進行藥液充塡且進行充填部的密 封。在該狀態尙未形成熔接部32、34，所以藥劑袋內部（ 下側隔室2 0 )是經由小孔3 6而與排出口 1 2的內部通路1 2， 〇 連通。因此，藉由將袋部全體加熱到用來進行內部滅菌的 預定溫度，將輸送液蒸氣經由小孔36導入到排出口 12的0 部，所以能順利在濕熱下將排出口 1 2滅菌。在滅菌後形成 熔接部32、34，小孔36成爲如第2圖的封閉狀態。 第5圖是設置有翼片28的排出口 12的延伸部12— 2的上 壁面的前端部分的放大圖。翼片28的外周的薄片部30作成 朝藥劑袋內部側突出而呈圓形的前端形狀，而薄片部3 0其 前端部位30— 1構成不連續部位。當藥劑袋10開通時，藥 〇 劑袋10的與排出口 12的連接部位，如第4圖所示擴張變形 ，此時與施加於翼片28的外力比較起來，薄片部30是變弱 的設定。可是，翼片28的擴張，僅依賴於藥劑袋開通時的 在排出口 12的安裝部附近的藥劑袋的變形（膨脹），藉由開 通時的狀況而能預定薄片部3 0難產生破壞的情況。薄片部 3 0藉由將前端部位30— 1作成不連續，則在該部位會產生 應力集中，積極促使利用施加於翼片2 8的外力導致力矩最 大的前端部位30—1開始破裂，而能預期有確實的破裂動 作。也就是說，如果前端部位3 0 — 1開始破裂的話，能以 -15- 201040083 該處作爲基準點沿著薄片部3 0傳播破壞’而能預期更確實 的開放動作。在第5圖的實施方式’薄片部30的前端部的 其中一方側，藉由排出口 12的延伸部12一 2的寬度方向中 心線上的中心〇 1上的內外的同心圓C 1、C 1 ’所構成，另一 方側，藉由由中心◦ 1偏置的中心02上的內外的同心圓C2 、C2’所構成。因此，在其中一側的同心圓C1、C1’與另一 側的同心圓C 2、C 2，接合的前端部3 0 — 1 ’能在薄片部3 0形 成不連續部。 在第2圖，彈簧40(該發明的彈性構件）’是用來幫 助藥劑袋10的開通時的翼片28的確實開通而設置於排出口 12內。彈簧40藉由金屬等的帶片（針對其形狀參考第1圖 )所構成，一端部40—1位於擴徑部12— 1’另一端部12 — 2形成爲J型的彎曲部。由於藥劑袋尙未開通，所以在翼片 28在封閉位置的第2圖的狀態，彎曲部40— 2以第4圖的實 線所示是在於從原來形狀撓曲的狀態（第4圖的兩點鏈線 40— 2’），根據其撓曲而彈力將翼片28朝開放方向彈壓， 該彈壓力未達到薄片部30的破裂強度，翼片28保持封閉狀 態。當藥劑袋開通時，該彈壓力會追加於：藥劑袋開通時 的排出口 12的安裝部附近的藥劑袋擴張導致的開放方向的 力，所以會幫助翼片28朝開放方向移動，能達到使翼片28 更確實地到達開放位置。第4圖顯示彈簧40的前端部從翼 片2S封閉時的收縮狀態12— 27藉由彈力而擴張的狀態。作 爲彈簧40朝排出口 12內部的安裝方式，雖然在第2圖的實 施方式預定了將外側端部4 0 — 1黏接於排出口〗2的底壁面 -16- 201040083 的方式，而也可取代黏接方式，在排出口 12的底壁面形成 溝部，藉由使彈簧嵌裝卡止於該溝部，而以非黏接安裝 的方式。作爲彈簧40的材料，也可用塑膠帶片，藉由作成 顯眼的顏色，則可達到：當翼片2 8開放時，根據其顏色可 看出翼片2 8已經打開，進而了解利用弱密封部1 8的開通而 完成隔室20、22間的藥劑混合操作。 接著，針對該發明的藥劑袋的輸送液作業來說明，平 〇 常時（弱密封部尙未開通時）翼片28是在藉由點密封部32 而溶接於藥劑袋1 〇的相對向內面的第2圖的狀態，在該狀 態，翼片28是藉由薄片部30而與排出口 12—體化，排出口 1 2的內部通路1 2 ’是相對於藥劑袋1 〇的內部空洞部封閉。 而即使將輸送液套件的穿刺針穿刺於橡膠栓26也無法進行 藥劑的排出，則可預先防範在隔室20、22間的藥劑的未混 合狀態則進行液體輸送的這樣錯誤操作。而當點滴結束時 ，將開口部3 5封閉的話’雖然仍有液體殘留的可能性，而 C) 因爲具有彈簧4〇 ’所以點滴結束時不會使開口部35封閉， 可防止液體殘留。 弱密封部18的開通，是將藥劑袋1〇平坦放置於桌子等 上面’藉由以手掌加壓來進行藥劑袋1〇內的液體輸送（隔 室20、22的任何液體輸送都可以）。也就是說，藉由加壓 而所施加的藥液的壓力’在弱密封部18讓藥劑袋1〇的兩層 分離’而將隔室20、22連通，將之前分離收容於隔室2〇、 22的藥液混合。當弱密封部18開通時，藥劑袋1〇在與排出 口 12的連接部會如第4圖擴張變形，藉由點密封部32而堅 17- 201040083 固連接於藥劑袋相對向面部的翼片28，會與藥劑袋的擴張 移位連動而擴張彈壓，在該外力下會破壞薄片部30，翼片 2 8如第4圖所示地轉動，形成開口部3 5，所以將排出口 i 2 的內部通路1 2 ’與藥劑袋1 〇的內部空洞部連通，混合藥劑 從藥劑袋1 0導入到排出口 1 2的內部通路1 2 ’，將輸送液套 件的穿刺針穿刺於橡膠栓26，而能進行液體輸送。而藉由 對彈簧進行著色，則可達到利用目視來確認開通狀態。 以下，針對作爲合成樹脂成型件的該發明的排出口 1 2 的成型步驟加以說明，第6圖是用來將第2圖的排出口 12成 型用的模具，是由：上下的拼合模41、42、型芯（芯銷） 44所構成’在上下的拼合模41、42、型芯44之間，形成有 與第2圖的排出口 12爲相輔助的形狀的模腔46。上下的拼 合模41、42的拼合面D，其位置沿著排出口 12的長軸方向 中心線’藉由成型後的拼合模的分離，而可進行製品的頂 出。型芯44在一端部44 — 1 (排出口 1 2的擴徑部1 2 — 1側的 成型部位）是保持在上下的拼合模41、42之間，而另一端 (排出口 1 2的延伸部1 2 — 2的前端側的成型部位）基本上 是自由的’也就是說’型芯4 4是懸臂支承。上側的拼合模 4 1的相對於型芯4 4的突出部位4 1 一 1，是排出口丨2的藥劑 袋內延伸部12— 2的上面的翼片28的外周的薄片部3〇的成 型部。下模42與型芯44之間的小徑突出部42— 1，是排出 口的藥劑袋內延伸部12— 2的下面的滅菌用小孔36的成型 部位。而於型芯44的範圍在上下的拼合模41、Μ以平常的 方式設置有熔融樹脂的注入澆口 48。來自注入澆口 48的溶 •18- 201040083 融樹脂基本上從側面注入到模腔46，而型芯44是懸臂支承 ，在突出部位4 1 一 1的部位其路線很狹窄，所以因爲較大 的樹脂流動阻力，型芯44的自由端部44 一2側容易朝第6圖 的下方移位，而突出部位4 1 — 1與型芯4 4的間隔加寬，突 出部位41— 1是在與型芯44之間的成型部也就是排出口 12 的薄片部3〇的厚度容易大於預期値。在該情況，薄片部30 的破壞強度會大於設定値，當藥劑袋開通時則很難進行確 〇 實的破壞。爲了因應該問題，如第6圖所示，將輔助的注 入澆口 50形成爲：開口於模腔46的面對於型芯44的端面 44A的相對向部位。在型芯44形成錐狀的輔助注入孔54， 注入孔54的其中一端的縮徑部開口於上模的突出部位4 1 — 1，另一端的擴徑部在型芯端面側擴徑。設置於型芯44的 前端的注入孔54是直接開口於薄片部的成型部也就是突出 部位4 1 一 1，所以熔融樹脂朝該部位的注入能無阻力地進 行，樹脂會立即埋助該部位，所以會避免成型中的型芯44 Ο 前端的晃動，可將薄片部的厚度設定爲預期値。在成型後 雖然會殘留有因應於注入孔54的成型部位，而當脫模時該 成型部位會在縮徑部側被摘下。 第8圖是顯示爲了確實進行藥劑袋開通時的擋板開放 而將薄片部的厚度設定爲預期的模具的構造的其他實施方 式。在該實施方式，上部拼合模141的薄片部的成型部 141— 1其與型芯144的相對向面部作成凹凸形狀。在第9圖 顯示藉由該成型裝置所成型的排出口 112的前端形狀，排 出口 112的藥劑袋內延伸部112— 2的上壁面的翼片128，同 -19 - 201040083 樣藉由作爲脆弱部的薄片部132—體生成於藥劑袋內延伸 部112—2的剩餘的部位。可是，薄片部I32其上面呈凹凸 面。模具成型後的樹脂的冷卻其厚片部的收縮情形很大’ 所以厚片部分會使薄片部分緊繃，薄片部分會變得更薄’ 因此可更確實地進行·利用藥劑袋開通時的外力將作爲脆 弱部的薄片部132破壞。 第10圖是顯示爲了確實進行藥劑袋開通時的擋板開放 而將薄片部的厚度設定爲預期的模具的構造的另外實施方 式。在該實施方式，上部拼合模241的薄片部的成型部 241 — 1是作成：其與型芯244的相對向面部越前端其高度 越低的階段形狀。在第1 1圖顯示藉由該成型裝置所成型的 排出口 112，排出口 212的藥劑袋內延伸部212 — 2的上壁面 的翼片228 ’同樣藉由作爲脆弱部的薄片部232一體生成於 藥劑袋內延伸部21 2— 2的剩餘的部位。可是，薄片部23 2 其上面形狀爲越前端其高度越低的階段形狀。藉此而成型 時’樹脂從厚片部流入’所以壓力不易施加在前端側，型 芯的晃動情形較小，可讓前端的薄片部穩定成型。因此可 從目U端部更確實地進行：利用藥劑袋開通時的外力將作爲 脆弱部的薄片部232破壞。而取代階段形狀作成越前端越 低的錐狀形狀也可得到同樣的效果。 【圖式簡單說明】 弟1圖是該發明的第一富施卞Λ* 貫施方式的多室容器的俯視圖 -20- 201040083 第2圖是第1圖的多室容器的局部縱剖面圖（沿著第】 圖的11 一 11線顯示的端視剖面圖）。 第3圖是第1圖的多室容器的排出口的前端部分的橫剖 面圖（沿著第1圖的III— III線顯示的端視剖面圖）。 第4圖是第2圖的多室容器的排出口的前端部分的放大 圖（翼片以開放狀態顯示）。 第5圖是第1圖的多室容器的排出口的前端部分的放大 〇 圖。 第6圖是用來將多室容器的排出口予以成型的成型裝 置（模具及型芯）的槪略剖面圖（模具前端部是沿著破，線 表示，該破線沿著第7圖的VI— VI線）。 第7圖是圖的成型裝置的局部俯視圖。 第8圖是將多室容器的排出口成型用的其他實施方式 的成型裝置的局部剖面圖。 第9圖是藉由第8圖的成型裝置所成型的排出口的前端 部分的上視圖。 第10圖是將多室容器的排出口成型用的另外實施方式 的成型裝置的局部剖面圖。 第11圖是藉由第10圖的成型裝置所成型的排出口的前 端部分的顯示圖。 【主要元件符號說明】 1 0 :藥劑袋 1 2 :排出口 -21 - 201040083 1 2 — 2 :排出口的朝藥劑袋的延伸部 1 4 :強密封部 1 8 :弱密封部 2 0、2 2 :隔室 2 8 :翼片（該發明的開閉構件） 3 0 :薄片部3 0 (該發明的脆弱部） 30— 1 :薄片部前端的不連續部 3 2、3 4 :熔接部（點密封） 3 5 :翼片破壞後的排出口的開口部 3 6 :滅菌用小孔 40 :彈簧 41、42:排出口的成型用的上下的拼合模 44 :型芯（芯銷） 46 :模腔 48 :熔融樹脂的注入澆口 5 0 :輔助的注入澆口 -22-201040083 VI. Description of the Invention: [Technical Field] The present invention relates to a multi-chamber container in which a plurality of compartments are separately separated by a weak seal portion, thereby forming a plurality of compartments in which respective medicaments are sealed and housed. According to the configuration, after the medicines from the respective compartments are mixed by the opening of the weak seal portion, the medicine is administered from the opened discharge port; more specifically, it is about the multi-chamber container, and it is more sure to prevent the weak seal portion. The wrong operation is performed when the medicine is not opened. [Prior Art] As a multi-chamber container for transporting liquid, a weak seal portion (partition wall) obtained by relatively low-temperature welding of a facing surface of a chemical bag made of a soft film is used to separate a plurality of different chemical liquids. Compartment. In the outer periphery of the drug bag, the welding work is a discharge port (mouth portion) of the plastic molded product, and the discharge port is formed in a cylindrical shape, and the inner cavity portion is opened at one end side of the compartment, and the other is located outside the drug bag. A rubber plug is provided at one end. Before the drug is administered to the patient, the weak seal is peeled off by pressurizing the drug bag from the outside. Then the internal cavity of the drug bag becomes a chamber and the two liquids are mixed. When the puncture needle of the liquid kit punctures the rubber plug, the drug solution can be used to administer the drug solution. Therefore, in the medical hybrid multi-chamber container, before the administration of the chemical liquid, it is necessary to perform the operation of mixing the two liquids by opening the weak seal portion, and on the other hand, if the weak seal portion is not opened. If the rubber plug of the discharge port is punctured, the chemical solution in the compartment on the discharge port side may be erroneously operated. -5-201040083 In order to cope with such a problem, the opening and closing member is provided in the discharge port in conjunction with the expansion and displacement of the drug bag when the weak seal portion is opened (Patent Document 1). In order to solve the same problem as the operation of transporting the liquid in the case where the weak seal portion is not opened, it has also been proposed to provide a slight increase in the welding temperature before the discharge port, and to open the opening of the weak seal portion between the compartments more slowly. The technique of the second weak seal portion (Patent Documents 2 and 3). In addition, there is a technique in which a fragile portion is provided at the discharge port, and the weak portion is broken by the deformation of the drug bag when the weak seal portion is opened, and the discharge port is opened (Patent Document 4). [Patent Document 1] Japanese Laid-Open Patent Publication No. Hei. No. Hei. No. Hei. No. Hei. [Invention of the Invention] -6-201040083 [Problem to be Solved by the Invention] In the prior art, the opening operation of the opening and closing member depends on the expansion deformation of the medicine bag for opening the weak seal portion. Therefore, the relationship between the external force required for the opening operation of the opening and closing member and the force applied to the drug bag in the weak seal portion is only the opening of the weak seal portion, and the opening and closing of the opening and closing member cannot be performed (the liquid medicine is discharged from the discharge portion). discharge). Due to the opening operation of the opening and closing member, the opening and closing member is connected to the discharge port by the fragile portion, and the weak portion is broken by the expansion deformation of the general bag opened by the weak seal portion, thereby opening the opening and closing member, but the problem is difficult. The fragile portion at the time of molding the discharge port is controlled to a desired thickness, which becomes a bottleneck in the molding step. Further, since the destruction of the fragile portion and the accompanying opening operation of the opening and closing member depend on the expansion and deformation of the drug bag, the problem is that the external force for breaking the fragile portion is not necessarily as expected, and when the weak seal portion is opened, the fragile portion is Destruction does not necessarily all begin smoothly. 〇 In view of the above problems, the present invention has an object to more reliably perform the opening of the opening and closing member achieved by opening the weak seal portion. [Means for Solving the Problem] According to the first aspect of the invention, the present invention provides a multi-chamber container which is provided with a soft film formed in order to separate the inner cavity portion into a plurality of compartments for accommodating the drug. In addition, the pharmaceutical bag having the welded portion formed by the opposite surface of the chemical bag which can be peeled off by pressure, the discharge port which is attached to the drug bag, and the opening of the discharge port for the transfer liquid are opened in 201040083. a plug that is attached to the discharge port to the outside of the drug bag, an opening and closing member that normally opens and closes the inside of the drug bag, and an opening and closing member that is connected to the discharge port in order to normally close the opening, and is provided by the drug bag. The external fragile portion for breaking the external force of the welded portion and the elastic member that is biased toward the opening direction from the inside so as not to break the elastic force of the fragile portion. In the first aspect of the invention, the elastic member is formed by forming the elastic material into a plate shape, wherein one end abuts against the inner surface of the discharge port, and the other end abuts against the inner surface of the opening and closing member. According to a second aspect of the present invention, the present invention provides a multi-chamber container including a soft film and a pressure-removable portion for separating the inner cavity portion into a plurality of compartments for accommodating the drug. The medicine bag of the welded portion formed by the opposing surface of the welding agent bag, the discharge port attached to the drug bag, the opening of the inside of the discharge port for opening the drug bag, and the outside of the drug bag are attached to the row. The plug body of the outlet, the opening and closing member that normally opens and closes the inside of the drug bag, and the opening and closing member are connected to the discharge port in order to normally close the opening, and are broken by an external force from the outside of the drug bag for peeling off the welded portion. The fragile portion; the fragile portion has a shape in which the front end has a discontinuous portion. In the second aspect of the invention, the discontinuous portion at the tip end of the fragile portion can be formed by the intersection of a circle having a different center and outer diameter. According to a third aspect of the invention, the present invention provides a multi-chamber container which is formed of a soft film and which is provided with a pressure-peelable separation in order to separate the internal cavity portion into a plurality of compartments for accommodating a drug. Ground welding agent-8- 201040083 The drug bag of the welded portion formed by the opposing faces of the bag, the discharge port attached to the drug bag, the opening of the inside of the drug bag opening to the inside of the discharge port for the transfer liquid, and the facing of the drug bag a plug that is externally attached to the discharge port, an opening and closing member that normally opens and closes the inside of the drug bag, and an opening and closing member that is connected to the discharge port to close the opening, and is used for peeling and welding from the outside of the drug bag. The fragile portion that is destroyed by the external force of the portion; the thickness of the fragile portion changes along the long axis direction. In the third aspect of the invention, the fragile portion may have a cross-sectional shape that is wavy along the long axis direction, or the fragile portion may have a stepped cross-sectional shape that decreases toward the distal end side along the long axis direction. According to a fourth aspect of the invention, there is provided a cylindrical discharge port which is attached to a peripheral portion of a drug bag which is formed of a soft film and which separates the internal cavity portion. A plurality of compartments for accommodating the drug, and a welded portion including a facing surface for welding the drug bag by pressure peeling, the cylindrical discharge port having an opening and closing portion Ο, the opening and closing portion being interposed The fragile portion is connected to an extension portion inside the drug bag, and is opened by an external force from the outside of the drug bag for peeling off the welded portion to break the fragile portion, and is characterized by: having a center line along the long axis direction of the discharge port a divided mold, and a core which is formed in the mold and the discharge port by the center of the mold, and which is provided with a molten resin from the outer peripheral side of the cavity; The mold is directly opened through the core end surface to the introduction path of the molten resin at the weak portion forming portion of the cavity. According to the fifth aspect of the invention, there is provided a cylindrical discharge port forming device -9 - 201040083 'The cylindrical discharge port is attached to the peripheral portion of the drug bag: the drug bag is formed of a soft film to remove the internal cavity portion Separating into a plurality of compartments for accommodating a drug, and providing a welded portion formed by a facing surface that melts and peels the drug bag; the cylindrical discharge port includes an opening and closing portion, and the opening and closing portion is separated The fragile portion is connected to the extending portion toward the inside of the drug bag, and is opened by an external force from the outside of the drug bag for peeling off the welded portion to break the fragile portion, and is characterized in that: the long axis direction along the discharge port is provided a mold that divides the center line, and a core that is formed in the cavity by the mold and the discharge port by the center hole of the mold; the portion of the mold at the molding portion of the fragile portion of the cavity is oriented toward the core It changes along the long axis. According to the fifth aspect of the invention, the shape in which the height changes along the long axis direction is a cross-sectional shape that is wavy along the long axis direction, or a shape in which the height changes along the long axis direction, and the front end side is made lower along the long axis direction. Stage shape or slope shape. [Effect of the Invention] According to the first aspect of the invention, the elastic member that presses the opening and closing member in the opening direction without breaking the elastic force of the fragile portion is provided, and the elastic member can assist the breakage of the fragile portion and the opening and closing of the broken portion. The movement of the member in the opening direction allows the opening and closing member to be surely opened, and the medicine is surely circulated from the drug bag toward the discharge port. On the other hand, when the opening and closing member is opened, the elastic member can be visually observed from the opening. Therefore, the color of the elastic member can be used as an index for the positive opening of the medicine bag by the combination of the coloring of the elastic member, and the erroneous operation can be prevented -10- 201040083. On the other hand, when the drip is completed, if the opening is closed, there is a possibility that the liquid remains. However, by having the elastic member, the opening is not closed when the drip is completed, and there is an effect of preventing liquid from remaining. According to the second invention, the fragile portion is formed to have a discontinuous portion at the tip end, and the discontinuous portion at the distal end is used as a reference point to be surely started: the drug bag at the connection portion of the opening and closing member is opened by the opening of the weak seal portion. The breakage of the fragile portion achieved by the expansion is such that the opening operation of the weak seal portion and the opening operation of the Ο opening and closing valve are surely interlocked. According to the third aspect of the invention, the cross-sectional shape of the fragile portion is changed in the longitudinal direction, and a thin portion can be partially formed on the distal end side, and a partial thin portion of the distal end can be used as a reference point to be surely started: opening of the weak seal portion Further, the breakage of the fragile portion by the expansion of the drug bag at the connection portion of the opening and closing member is performed, and the opening operation of the weak seal portion and the opening operation of the opening and closing valve can be surely interlocked. According to the fourth aspect of the invention, the molding apparatus for molding the discharge port is provided with the introduction passage of the molten resin from the outer peripheral surface side facing the cavity, and the mold opening directly from the mold via the core end surface. The introduction path of the molten resin at the portion where the fragile portion of the cavity is formed; when the molding is performed, the resin can be directly filled to the fragile portion forming portion of the discharge port, and the displacement of the front end of the core in the molding step can be prevented, and the fragile portion can be prevented from being typed. The core is thickened by the deviation' and can be formed into the desired thickness. According to the fifth aspect of the invention, in the molding apparatus for molding the discharge port, the portion of the mold of the molding portion of the cavity where the mold portion is formed, the height of the core is changed along the longitudinal direction, so that the molding is cooled. The result of the product is -11 - 201040083. The shrinkage is concentrated on the thicker portion, and the thickness of the thinner portion can be further reduced by the contraction caused by the shrinkage, and the opening toward the discharge port at the time of the opening operation of the product can be made. The linkage is more certain. [Embodiment] In Figs. 1 and 2, the multi-chamber container is composed of a flat drug bag 10' and a discharge port 12. The drug bag 1 is a multilayer soft film such as polyethylene or polypropylene having a thickness of 200 to 400 μm. In the case of using a polyethylene film, the outer periphery is sealed by a strong sealing portion 14 which is formed by pressurizing at a high temperature of 150 t which is much higher than the softening temperature of the film. Rectangular flat bag shape. A hanging hole is bored in an upper end (not shown) of the strong seal portion 4, and the drug bag 1 is suspended and held on a drip table or the like by a hanging hole to perform a liquid transfer operation such as dripping or dialysis. The intermediate portion of the longitudinal direction of the bag 10 covers a weak seal portion (peelable weld portion) or a partition wall 1 8 having a full width extending, and the front and back surfaces of the drug bag 10 are welded by the weak seal portion 18 to constitute: The inner cavity portion of the drug bag 〇 is divided into a first compartment 20 on the side of the discharge port 12 and a partition wall of the second compartment 22 on the side of the suspension hole. The first compartment 20 is filled with the first drug solution, and the second compartment 22 is filled with the second drug solution. The weak seal portion 18 is formed by low-temperature pressurization of the front and back layer ' of the polyethylene film forming the drug bag 1 以 at a temperature slightly higher than the softening temperature of l3〇r. Therefore, in a state where the respective chemical liquids are accommodated in the first compartment 20 and the second compartment 22, the chemical solution of the medicine bag 1 is pressurized from the outside in the portions of the cells 20 and 22, and the strong sealing portion is provided.丨4 remains as it is (no -12-201040083 peeling off) 'The weak seal portion 18 is peeled off and opened, and the first chemical liquid and the second chemical liquid can be mixed. The discharge port (the mouth portion 2 is a plastic having a thickness which can maintain the rigidity of the shape, or a plastic such as polypropylene or polyolefin (in order to obtain the adhesion to the chemical bag 1 ), it is preferable to A molded article of the same type of plastic material as the drug bag i. The upper and lower plastic soft film layers constituting the strong seal portion 14 on the outer periphery of the drug bag are welded at the portion 14 of the discharge port 12 so as to be sandwiched between the discharge ports 12 In the outer circumference, the discharge port 12 is configured to be firmly connected to the medicine bag 10. As shown in Fig. 2, one end of the discharge port 12 (the lower end of Fig. 1) forms an enlarged diameter portion 1 2 - 1 '. The portion 1 2 - 1 forms an opening portion 24 on the bottom surface, and a rubber plug 26 (the plug body of the invention) is fitted into the opening portion 24. As in the conventional method, when the liquid is transported, the needle of the transport liquid kit is inserted. (not shown) punctures the rubber plug 26. The other end of the discharge port 12 (the upper end of Fig. 1) forms an extension 12-2 toward the drug bag 10, and the extension 12-2 is as shown in Fig. 3. Make a rectangular cross-sectional shape, as shown in Figure 1, the front end 1 2 A is closed. When the portion 1 2 - 2 is extended long, the external force for breaking the sheet portion to be described later by the expansion of the drug bag when the drug bag is opened becomes large, but the molding difficulty of the sheet portion becomes high, so 2〇~3 A length of 0 mm is preferred. An upper baffle or flap 28 (opening and closing member of the invention) is formed on the upper wall of the extending portion 12-2. The entire outer periphery of the flap 28 is interposed between the sheet portions 30 ( The fragile portion of the invention is integrally molded to the remaining portion of the upper wall of the extending portion 12-2 of the discharge port 12. Thus, the flap 28 normally completely blocks (closes) the inner cavity of the medicament bag 10 (lower) The side compartments 20 - 13 - 201040083 ) communicate with the internal passage 12 ′ of the discharge opening 12 . As shown in Fig. 2, the upper surface of the vane 28 and the extension of the discharge opening 12 facing the vane 28 The lower surface of the 1 2 - 2 is firmly welded to the opposite inner surface of the plastic film constituting the medicine bag 10. The portion of the plastic film welded to the air piece 28 is indicated by 32, and is welded to the extension 1 by 34. The part of the plastic film of 2 to 2. As the fusion temperature of the parts 32, 34 The temperature is about the same as the fusion of the strong seal portion 14, and the case of polyethylene is about 150 ° C. Therefore, when the weak seal portion 18 is peeled off for the purpose of mixing the medicaments of the compartments 20, 22 The flap 28 is not peeled off from the drug bag 1〇 and is displaced in conjunction with the expansion and displacement of the drug bag. Since the sheet portion 30 is weak, it cannot withstand the external force at the time of the expansion displacement, and at least a part of the sheet portion 30 ( Most of the front end portions are broken, and the fins 28 are rotated from the closed state of Fig. 2, as shown in Fig. 4, where the external force is weak and the hard-to-break root portion is centered, and the extension portion 12 of the discharge port 12 is The upper surface of 2 is formed such that the internal passage 1 2 ' of the discharge port 1 2 is communicated to the opening portion 35 of the inside of the drug bag. As the means for welding the fins 28 of the portions 32, 34 to the opposing faces of the drug bag 10, a so-called point sealing device can be employed. That is, the dot sealing device is provided with a pair of welded members having the shapes of the welded portions 32 and 34, and the welded portion is used to slice the plastic film constituting the drug bag and the welded portion of the discharge port 12, that is, the wing. The upper surface of the sheet 2 8 and the lower surface of the extending portion 12-2 are sandwiched, and the plastic film constituting the drug bag is sliced by the high temperature of the sealing member, and the fins 28 and the extension portion 12-2 are sealed. On the other hand, if the width of the inner extending portion 12-2 of the medicine bag as the discharge port 1 is too narrow, the welding area becomes too small, and the required strength cannot be obtained, so that about 7.5 mm is preferable. -14- 201040083 As shown in Fig. 2 and Fig. 4, the lower wall surface of the extension portion ι2_2 of the discharge port l2 is provided with a small hole 3 6 for achieving the moist heat sterilization of the drug bag 丨〇 . In other words, in the state in which the discharge Q12 is attached to the drug bag 10 (the sheet portion 30 is not broken, and the flap 28 is closed), and the weak seal portion 18 is formed, the cells 20 and 22 are filled with the liquid medicine and performed. Sealing of the filling section. Since the welded portions 32 and 34 are not formed in this state, the inside of the drug bag (the lower compartment 20) communicates with the internal passage 1 2 of the discharge port 1 through the small hole 36. Therefore, by heating the entire bag portion to a predetermined temperature for internal sterilization, the transfer liquid vapor is introduced into the zero portion of the discharge port 12 through the small hole 36, so that the discharge port 12 can be smoothly sterilized under moist heat. After the sterilization, the welded portions 32 and 34 are formed, and the small holes 36 are closed as shown in Fig. 2. Fig. 5 is an enlarged view of the front end portion of the upper wall surface of the extending portion 12-2 of the discharge port 12 provided with the flap 28. The outer peripheral sheet portion 30 of the flap 28 is formed into a circular front end shape that protrudes toward the inner side of the drug bag, and the front end portion 30-1 of the sheet portion 30 constitutes a discontinuous portion. When the medicine bag 10 is opened, the connection portion of the drug solution bag 10 with the discharge port 12 is expanded and deformed as shown in Fig. 4, and at this time, the sheet portion 30 is weakened as compared with the external force applied to the flap 28. set up. However, the expansion of the flap 28 depends only on the deformation (expansion) of the drug bag in the vicinity of the attachment portion of the discharge port 12 when the drug bag is opened, and it is possible to predict that the sheet portion 30 is less likely to be broken by the state at the time of opening. Happening. When the sheet portion 30 is made discontinuous in the front end portion 30-1, stress concentration occurs in the portion, and the front end portion 30-1 which causes the maximum moment by the external force applied to the flap 28 is actively caused to start to be broken. A definite rupture is expected. That is to say, if the front end portion 3 0 - 1 starts to be broken, it is possible to predict the more accurate opening action by propagating the destruction along the sheet portion 30 with the point -15 - 201040083 as the reference point. In one of the front end portions of the sheet portion 30 of the fifth embodiment, the inner and outer concentric circles C 1 and C 1 on the center line 1 on the center line in the width direction of the extending portion 12 - 2 of the discharge port 12 are formed. The other side is composed of inner and outer concentric circles C2 and C2' on the center 02 offset by the center ◦ 1. Therefore, the concentric circles C1, C1' on one side and the concentric circles C2, C2 on the other side, the joined front end portion 3 0 - 1 ' can form a discontinuous portion in the sheet portion 30. In Fig. 2, the spring 40 (the elastic member of the invention) is provided in the discharge port 12 for facilitating the opening of the flap 28 when the medicine bag 10 is opened. The spring 40 is constituted by a strip of metal or the like (refer to Fig. 1 for its shape), and the one end portion 40-1 is located at the other end portion 12-2 of the enlarged diameter portion 12-1' as a J-shaped bent portion. Since the medicine bag 尙 is not opened, in the state of the second figure in the closed position of the flap 28, the curved portion 40-2 is in a state of being deflected from the original shape as indicated by the solid line in FIG. 4 (Fig. 4 The two-point chain line 40-2') elastically biases the flap 28 toward the opening direction according to its deflection, and the elastic pressure does not reach the breaking strength of the sheet portion 30, and the flap 28 remains closed. When the medicine bag is opened, the elastic pressure is added to the force in the opening direction caused by the expansion of the medicine bag in the vicinity of the attachment portion of the discharge port 12 when the medicine bag is opened, so that the flap 28 is moved in the opening direction. The flaps 28 more reliably reach the open position. Fig. 4 shows a state in which the front end portion of the spring 40 is expanded by the elastic force in the contracted state 12-27 when the flap 2S is closed. As a method of attaching the spring 40 to the inside of the discharge port 12, although the embodiment of Fig. 2 is intended to adhere the outer end portion 40-1 to the bottom wall surface of the discharge port 〖2-16-201040083, Instead of the bonding method, a groove portion is formed on the bottom wall surface of the discharge port 12, and the spring is fitted and locked to the groove portion to be non-adhesively mounted. As the material of the spring 40, a plastic strip can also be used, and by making a conspicuous color, it can be achieved that when the flap 28 is open, it can be seen that the flap 28 has been opened according to its color, thereby understanding the use of the weak seal. The opening of 1 8 completes the mixing operation of the medicament between the compartments 20, 22. Next, with respect to the operation of the transfer liquid of the drug bag of the present invention, it is explained that the flap 28 is in contact with the opposite inner surface of the drug bag 1 by the dot seal portion 32 at all times (the weak seal portion is not opened). In the state of Fig. 2, in this state, the flap 28 is formed integrally with the discharge port 12 by the sheet portion 30, and the internal passage 1 2 ' of the discharge port 1 is an internal cavity portion with respect to the drug bag 1 Closed. Further, even if the puncture needle of the transport liquid kit is punctured to the rubber stopper 26, the medicine cannot be discharged, and the erroneous operation of transporting the liquid in the unmixed state of the medicine between the cells 20 and 22 can be prevented in advance. On the other hand, when the dot is closed, the opening portion 35 is closed, and although there is still a possibility that the liquid remains, and C) has the spring 4〇', the opening portion 35 is not closed at the end of the spotting, and the liquid can be prevented from remaining. The opening of the weak seal portion 18 is such that the drug bag 1 is placed flat on a table or the like. The liquid in the drug bag 1 is transported by pressurizing the palm (any liquid transport of the cells 20, 22 is possible). In other words, the pressure of the chemical liquid applied by pressurization 'separates the two layers of the drug bag 1 在 in the weak seal portion 18', and the cells 20 and 22 are connected to each other and are separately separated into the compartment 2〇. 22, the liquid medicine is mixed. When the weak seal portion 18 is opened, the connection portion of the drug bag 1 at the connection with the discharge port 12 is expanded and deformed as shown in FIG. 4, and the point seal portion 32 is used to securely connect the flap to the face of the drug bag. 28, the elastic pressure is expanded in conjunction with the expansion displacement of the medicine bag, and the sheet portion 30 is broken by the external force, and the flap 28 is rotated as shown in Fig. 4 to form the opening portion 35, so the discharge port i 2 is to be discharged. The internal passage 1 2 ' communicates with the internal cavity of the drug bag 1 , and the mixed drug is introduced from the drug bag 10 into the internal passage 1 2 ' of the discharge port 1 2 , and the puncture needle of the delivery liquid kit is punctured to the rubber stopper 26 . It can be used for liquid transport. By coloring the spring, it is possible to visually confirm the open state. Hereinafter, a molding step of the discharge port 1 2 of the invention as a synthetic resin molded article will be described. Fig. 6 is a mold for molding the discharge port 12 of Fig. 2, which is composed of a top and lower split mold 41, 42. The core (core pin) 44 is formed between the upper and lower split molds 41 and 42 and the core 44, and a cavity 46 having a shape complementary to the discharge port 12 of Fig. 2 is formed. The split surface D of the upper and lower split molds 41, 42 is positioned along the long-axis direction center line of the discharge port 12 by the separation of the formed split molds, whereby the product can be ejected. The core 44 is held between the upper and lower split molds 41, 42 at one end portion 44-1 (the molded portion on the enlarged diameter portion 1 2 - 1 side of the discharge port 1 2), and the other end (extension of the discharge port 1 2) The molding portion of the front end side of the portion 1 2 - 2) is substantially free, that is, the core 44 is a cantilever support. The protruding portion 4 1 - 1 of the split mold 41 of the upper side with respect to the core 44 is formed by the outer peripheral sheet portion 3 of the flap 28 of the upper end portion 12-2 of the discharge port 2 unit. The small-diameter protruding portion 42-1 between the lower mold 42 and the core 44 is a molding portion of the sterilization small hole 36 on the lower surface of the medicine bag inner extending portion 12-2 of the discharge port. On the other hand, the core 44 is provided with a molten resin injection gate 48 in the upper and lower split molds 41 and Μ in a usual manner. The melt from the injection gate 48 is filled into the cavity 46 substantially from the side, and the core 44 is cantilevered, and the route is narrow at the portion of the projection 4 1 -1, so because of the larger Resin flow resistance, the free end portion 44 of the core 44 is easily displaced toward the lower side of Fig. 6, and the interval between the protruding portion 41-1 and the core 44 is widened, and the protruding portion 41-1 is The molded portion between the cores 44, that is, the thickness of the sheet portion 3 of the discharge port 12 is easily larger than expected. In this case, the breaking strength of the sheet portion 30 is larger than the setting 値, and it is difficult to perform the tangible destruction when the medicine bag is opened. In order to solve the problem, as shown in Fig. 6, the auxiliary injection gate 50 is formed so as to open to the opposite end portion of the end face 44A of the core 44 of the cavity 46. The core 44 is formed with a tapered auxiliary injection hole 54, and the reduced diameter portion of one end of the injection hole 54 is opened to the protruding portion 41-1 of the upper mold, and the enlarged diameter portion of the other end is expanded in diameter on the side of the core end face. The injection hole 54 provided at the front end of the core 44 is a molded portion that is directly opened to the sheet portion, that is, the protruding portion 41 to 1. Therefore, the injection of the molten resin toward the portion can be performed without resistance, and the resin immediately buryes the portion. Therefore, the sway of the front end of the core 44 成型 during molding can be avoided, and the thickness of the sheet portion can be set to the desired 値. After the molding, a molding portion corresponding to the injection hole 54 remains, and when the mold is released, the molding portion is removed on the side of the reduced diameter portion. Fig. 8 is a view showing another embodiment of the structure of the mold for setting the thickness of the sheet portion in order to ensure the opening of the shutter when the medicine bag is opened. In this embodiment, the molded portion 141-1 of the sheet portion of the upper split mold 141 is formed in a concave-convex shape with respect to the facing portion of the core 144. In Fig. 9, the shape of the front end of the discharge port 112 formed by the molding apparatus is shown, and the fins 128 of the upper wall surface of the inner portion of the medicine bag in the discharge port 112 are flanked by -19 - 201040083. The thin portion 132 of the portion is formed in the remaining portion of the extending portion 112-2 of the drug bag. However, the sheet portion I32 has an uneven surface on its upper surface. The shrinkage of the slab portion of the resin after the molding of the mold is large. Therefore, the slab portion may make the sheet portion tight, and the sheet portion may become thinner. Therefore, it is possible to perform the force more reliably when the medicinal pouch is opened. The sheet portion 132 which is a fragile portion is broken. Fig. 10 is a view showing another embodiment of the structure of the mold for setting the thickness of the sheet portion in order to ensure the opening of the shutter when the medicine bag is opened. In this embodiment, the molded portion 241-1 of the sheet portion of the upper split mold 241 is formed in a step shape which is lower in height from the front end of the core 244 toward the front end. In Fig. 1, the discharge port 112 formed by the molding apparatus is shown, and the flap 228' of the upper wall surface of the medicine bag inner extension portion 212-2 of the discharge port 212 is also integrally formed by the sheet portion 232 as the fragile portion. The remaining portion of the extension 21 2-2 in the medicament bag. However, the shape of the upper surface of the sheet portion 23 2 is a step shape in which the height of the front end is lower. By this, the resin flows in from the slab portion. Therefore, the pressure is less likely to be applied to the tip end side, and the core is less swayed, so that the sheet portion at the tip end can be stably molded. Therefore, it is possible to more reliably perform the destruction of the sheet portion 232 as the fragile portion by the external force when the medicine bag is opened. The same effect can be obtained by replacing the stage shape with a tapered shape having a lower front end. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a plan view of a multi-chamber container of the first embodiment of the present invention. -20- 201040083 FIG. 2 is a partial longitudinal sectional view of the multi-chamber container of FIG. 1 ( A cross-sectional view along the line 11-11 of the first diagram). Fig. 3 is a cross-sectional view showing the distal end portion of the discharge port of the multi-chamber container of Fig. 1 (a cross-sectional view taken along line III-III of Fig. 1). Fig. 4 is an enlarged view of the front end portion of the discharge port of the multi-chamber container of Fig. 2 (the flap is shown in an open state). Fig. 5 is an enlarged plan view showing the front end portion of the discharge port of the multi-chamber container of Fig. 1. Figure 6 is a schematic cross-sectional view of a molding apparatus (mold and core) for molding a discharge port of a multi-chamber container (the front end portion of the mold is shown along a broken line, the broken line is along the VI of Fig. 7) — VI line). Fig. 7 is a partial plan view of the molding apparatus of the drawing. Fig. 8 is a partial cross-sectional view showing a molding apparatus of another embodiment for molding a discharge port of a multi-chamber container. Fig. 9 is a top view of the front end portion of the discharge port formed by the molding apparatus of Fig. 8. Fig. 10 is a partial cross-sectional view showing a molding apparatus of another embodiment for molding a discharge port of a multi-chamber container. Fig. 11 is a view showing the front end portion of the discharge port formed by the molding apparatus of Fig. 10. [Description of main component symbols] 1 0 : pharmacy bag 1 2 : discharge port 21 - 201040083 1 2 - 2 : extension of the discharge bag toward the drug bag 1 4 : strong seal portion 1 8 : weak seal portion 2 0, 2 2: compartment 2 8 : flap (opening and closing member of the invention) 3 0 : sheet portion 30 (the fragile portion of the invention) 30-1 : discontinuous portion at the front end of the sheet portion 3 2, 3 4 : welded portion ( Point seal) 3 5 : Opening portion of the discharge port after the vane breaks 3 6 : Small hole for sterilization 40 : Springs 41 and 42 : Upper and lower split molds 44 for molding the discharge port : Core (core pin) 46 : Cavity 48: Injection gate of molten resin 50: auxiliary injection gate-22-

Claims (1)

201040083 七、申請專利範圍： 1.一種多室容器，其特徵爲： 是具備有： 以軟質薄膜形成，爲了將內部空洞部分別分離成用來 收納藥劑的複數的隔室，而具備有可加壓剝離地熔接藥劑 袋的相對向面所構成的熔接部的藥劑袋、 安裝於藥劑袋的排出口、 Ο 使藥劑袋內部開口於輸送液用的排出口內部的開口部 、 面對藥劑袋外部地安裝於排出口的栓體、 平常將上述開口部對於藥劑袋內部進行開閉的開閉構 件、 爲了平常封閉開口部而將_閉構件連結於排出口，藉 由來自藥劑袋外部的用來剝離熔接部的外力而破壞的脆弱 部、 〇 以及從內側以不致於破壞脆弱部的彈力，將開閉構件 朝開放方向彈壓的彈性構件。 2 .如申請專利範圍第1項的多室容器，其中彈性構件 是將彈性材作成板狀所形成，其中一端抵接於排出口的內 面，另一端抵接於開閉構件的內面。 3.—種多室容器，其特徵爲： 是具備有： 以軟質薄膜形成，爲了將內部空洞部分別分離成用來 收納藥劑的複數的隔室，而具備有可加壓剝離地熔接藥劑 -23- 201040083 袋的相對向面所構成的熔接部的藥劑袋、 安裝於藥劑袋的排出口、 使藥劑袋內部開口於輸送液用的排出口內部的開口部 、 面對藥劑袋外部地安裝於排出口的栓體、 平常將上述開口部對於藥劑袋內部進行開閉的開閉構 件、 爲了平常封閉開口部而將開閉構件連結於排出口，藉 由來自藥劑袋外部的用來剝離熔接部的外力而破壞的脆弱 部； 上述脆弱部作成前端具有不連續部的形狀。 4. 如申請專利範圍第3項的多室容器，其中脆弱部的 前端的不連續部，藉由中心及外徑不同的圓的交叉來形成 〇 5. —種多室容器，其特徵爲： 是具備有： 以軟質薄膜形成，爲了將內部空洞部分別分離成用來 收納藥劑的複數的隔室，而具備有可加壓剝離地熔接藥劑 袋的相對向面所構成的熔接部的藥劑袋、 安裝於藥劑袋的排出口、 使藥劑袋內部開口於輸送液用的排出口內部的開口部 、 面對藥劑袋外部地安裝於排出口的栓體、 平常將上述開口部對於藥劑袋內部進行開閉的開閉構 -24- 201040083 件、 爲了平常封閉開口部而將開閉構件連結於排出口，藉 由來自藥劑袋外部的用來剝離熔接部的外力而破壞的脆弱 部； 上述脆弱部其厚度沿著長軸方向變化。 6.如申請專利範圍第5項的多室容器，其中脆弱部作 成沿著長軸方向呈波浪形的剖面形狀。 〇 7 ·如申請專利範圍第5項的多室容器，其中脆弱部作 成沿著長軸方向而前端側降低的階段狀或錐狀的剖面形狀 〇 8_—種成型裝置，是筒狀的排出口的成型裝置， 該筒狀的排出口安裝在藥劑袋的周緣部： 該藥劑袋，以軟質薄膜形成，爲了將內部空洞部分別 分離成用來收納藥劑的複數的隔室，而具備有可加壓剝離 地熔接藥劑袋的相對向面所構成的熔接部； 〇 該筒狀的排出口具備有開閉部， 該開閉部，隔介著脆弱部連接到朝藥劑袋內部的延伸 部，且利用來自藥劑袋外部的用來剝離熔接部的外力來破 壞脆弱部而開口，其特徵爲： 具備有： 沿著排出口的長軸方向中心線分割的模具、與藉由位 於模具的中心空洞’而在模具來與排出口輔助地形成模腔 的型芯； 且具備有：朝模腔的來自外周面側的熔融樹脂的導入 -25- 201040083 通路、以及從模具經由型芯端面直接開口於模腔的脆弱部 形成部位的熔融樹脂的導入通路。 9. 一種成型裝置’是筒狀的排出口的成型裝置， 該筒狀的排出口安裝在藥劑袋的周緣部： 該藥劑袋’以軟質薄膜形成，爲了將內部空洞部分別 分離成用來收納藥劑的複數的隔室，而具備有可加壓剝離 地熔接藥劑袋的相對向面所構成的熔接部； 該筒狀的排出口具備有開閉部， 該開閉部，隔介著脆弱部連接到朝藥劑袋內部的延伸 部，且利用來自藥劑袋外部的用來剝離熔接部的外力來破 壞脆弱部而開□，其特徵爲： 具備有： 沿著排出口的長軸方向中心線分割的模具、與藉由位 於模具的中心空洞，而在模具來與排出口輔助地形成模腔 的型芯； 模腔的脆弱部的成型部位的模具的部位，朝向型芯的 高度是沿著長軸方向變化。 10. 如申請專利範圍第9項的多室容器’其中高度沿著 長軸方向變化的形狀’是作成沿著長軸方向呈波浪狀的剖 面形狀。 1 1.如申請專利範圍第9項的多室容器’其中高度沿著 長軸方向變化的形狀，是作成沿著長軸方向而前端側降低 的階段狀或錐狀的剖面形狀。 -26-201040083 VII. Patent application scope: 1. A multi-chamber container, which is characterized by: It is provided with: a soft film formed, and is provided with a plurality of compartments for separating the internal cavity parts into medicines for storing medicines. The drug bag of the welded portion formed by the opposing surface of the chemical bag is welded and peeled off, the discharge port attached to the drug bag, and the opening of the drug bag inside the discharge port for the transfer liquid, facing the outside of the drug bag The plug body that is attached to the discharge port, the opening and closing member that normally opens and closes the inside of the drug bag, and the _ closing member are connected to the discharge port in order to normally close the opening, and are used for peeling and welding by the outside of the drug bag. The fragile portion that is destroyed by the external force of the part, the crucible, and the elastic member that presses the opening and closing member in the opening direction from the inside without breaking the elastic force of the fragile portion. 2. The multi-chamber container according to claim 1, wherein the elastic member is formed by forming the elastic material into a plate shape, wherein one end abuts against the inner surface of the discharge port and the other end abuts against the inner surface of the opening and closing member. 3. A multi-chamber container, comprising: a soft film formed, wherein the inner cavity portion is separated into a plurality of compartments for accommodating a drug, and a chemical agent capable of pressure-peeling is provided - 23-201040083 The drug bag of the welded portion formed by the opposing faces of the bag, the discharge port attached to the drug bag, the opening inside the discharge port for opening the drug bag, and the outside of the drug bag are attached to the outside of the drug bag. The plug body of the discharge port, the opening and closing member that normally opens and closes the inside of the drug bag, and the opening and closing member are connected to the discharge port in order to normally close the opening, and the external force from the outside of the drug bag for peeling off the welded portion is Destructive fragile portion; The fragile portion has a shape in which the front end has a discontinuous portion. 4. The multi-chamber container of claim 3, wherein the discontinuous portion of the front end of the fragile portion is formed by a cross of a circle having a different center and outer diameter to form a multi-chamber container, characterized by: In the case of forming a soft film, the inside of the cavity is separated into a plurality of compartments for accommodating the drug, and the drug bag having the welded portion formed by welding the opposing faces of the drug bag by pressure peeling is provided. And a discharge port that is attached to the drug bag, an opening that opens inside the drug bag to the inside of the discharge port for transporting the liquid, a plug that is attached to the discharge port to the outside of the drug bag, and the inside of the drug bag is usually opened to the inside of the drug bag. The opening and closing mechanism of the opening and closing device - 24,040,083, in order to close the opening, the opening and closing member is coupled to the discharge port, and the fragile portion is broken by an external force from the outside of the drug bag for peeling off the welded portion; The direction of the long axis changes. 6. The multi-chamber container of claim 5, wherein the fragile portion has a cross-sectional shape that is wavy along the long axis direction. The multi-chamber container according to claim 5, wherein the fragile portion is formed in a stepped or tapered cross-sectional shape in which the front end side is lowered along the long axis direction, and the cylindrical molding device is a cylindrical discharge port. The molding device has a cylindrical discharge port attached to a peripheral portion of the drug bag: the drug bag is formed of a soft film, and is provided for separating the internal cavity portion into a plurality of compartments for accommodating the drug. The welded portion formed by the opposing surface of the chemical bag is welded and peeled off; the cylindrical discharge port is provided with an opening and closing portion that is connected to the extending portion toward the inside of the drug bag via the fragile portion, and is utilized by An external force for peeling off the welded portion outside the drug bag to break the fragile portion, and is characterized by: a mold that is divided along a center line along a long axis direction of the discharge port, and a cavity that is located at a center of the mold a mold to form a core of the cavity with the discharge port; and the introduction of the molten resin from the outer peripheral side of the cavity to the cavity - 25-201040083, and the slave mode Introducing the molten resin passage of the fragile portion is directly open to the end face of the cavity formed by the core part. A molding apparatus ' is a cylindrical discharge port forming device, and the cylindrical discharge port is attached to a peripheral portion of the drug bag: the drug bag 'is formed of a soft film, and the inner cavity portion is separately separated for storage The plurality of compartments of the medicine are provided with a welded portion formed by a facing surface of the medicine bag that can be pressure-peeled and peeled off; the cylindrical discharge port includes an opening and closing portion that is connected to the fragile portion via the fragile portion The mold is opened to the extension portion inside the inside of the medicine bag, and the external force from the outside of the medicine bag is used to break the welded portion to break the fragile portion, and is characterized by: a mold that is divided along the center line of the long axis direction of the discharge port And a core which is formed in the cavity by the mold and assisted to form a cavity by the center hole of the mold; the portion of the mold at the molding portion of the fragile portion of the cavity, the height toward the core is along the long axis direction Variety. 10. The multi-chamber container 'in the shape in which the height varies along the major axis direction' in the ninth aspect of the patent application is a cross-sectional shape which is formed in a wave shape along the long axis direction. 1. The multi-chamber container of the ninth aspect of the invention is a shape in which the height changes along the major axis direction, and is formed in a stepped or tapered cross-sectional shape in which the distal end side is lowered along the longitudinal direction. -26-
TW99100692A 2009-01-19 2010-01-12 Multi-chamber container TW201040083A (en)

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JP5739155B2 (en) * 2010-12-27 2015-06-24 テルモ株式会社 Hollow body for medical container, discharge port for medical container, drug container for medical container, and medical container
JP6931516B2 (en) * 2015-09-24 2021-09-08 株式会社大協精工 Plug with port
JP6900153B2 (en) * 2016-04-21 2021-07-07 大和製罐株式会社 Syringe container
WO2018064263A1 (en) * 2016-09-29 2018-04-05 Cryovac, Inc. Multi-chamber iv bag and method of production thereof

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JP4472571B2 (en) * 2004-08-25 2010-06-02 テルモ株式会社 Cylindrical body for medical container, drug container for medical container, discharge port for medical container and medical container
EP2143413A4 (en) * 2007-04-27 2014-03-26 Ajinomoto Kk Double-cell container

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