JP4822860B2 - Medical multi-chamber container - Google Patents

Description

  The present invention comprises a plurality of storage chambers that individually enclose various unstable drugs that cause a change with time when blended at the same time, and opens each of the partition weak seals that partition the storage chambers. The present invention relates to a medical multi-chamber container in which a medicine sealed in a storage chamber can be mixed in a sterile state without generating foreign matter.

  Since patients who have undergone surgery such as gastrointestinal surgery are often unable to take orally, their nutritional management is generally performed by high-calorie infusion (IVH) for central intravenous administration. In IVH, carbohydrates, amino acids, and electrolytes, which are nutrient sources, are usually administered. For example, when glucose and amino acids are stored in the same container and stored, these solutions turn brown due to the so-called Maillard reaction. Need to be stored separately. For this reason, medical multi-chamber containers that individually store these drugs have become widespread in recent years.

  This medical multi-chamber container is composed of, for example, two storage chambers in which an infusion containing amino acid and an infusion containing glucose are respectively stored, and a sealing portion that partitions the storage chambers in isolation. The sealing portion is configured so that the storage chambers are always closed so that the respective drugs are not mixed and opened when used. When one storage chamber is pressed during use, the pressure in the storage chamber increases, the sealing portion is opened, and the two chambers of medicine are mixed. Subsequently, when the conduit is connected to the outlet provided in the multi-chamber container, the mixed liquid medicine can be administered to the patient.

  By the way, it is pointed out that when IVH is used for a long period of time, it causes deficiency of trace elements and vitamins not contained in the infusion preparation. However, since the liquid preparations of vitamins lack stability, it has been difficult to mix them into IVH infusion preparations. In order to solve this, the present applicant has proposed a multi-chamber container described in WO99 / 39679. In addition to the above-described conventional configuration, this multi-chamber container includes a small container that stores a vitamin solution in one storage chamber. The small container is configured to be opened by pressing from the outside. In use, the sealing part is opened to mix the chemical solutions in the two chambers, and from outside the storage chamber, a small container placed inside the container is pressed to open and the vitamin chemicals are removed. The mixture was mixed.

However, in the above configuration, in addition to opening the sealing portion, it is necessary to separately perform the opening operation of the small container, which causes a problem that the operation becomes complicated. In particular, such a complicated work is often a heavy burden on the operator in a busy medical field. Therefore, the present applicant has proposed a multi-chamber container described in International Publication No. 03/092574. The multi-chamber container is configured such that the small container is opened along with the opening of the weak seal portion for partitioning.
International Publication No. 99/39679 Pamphlet WO03 / 092574 pamphlet

  However, in the multi-chamber container as described above, when the small container 15 is opened, one first fixing portion 19 may be peeled off in rare cases as shown in FIG. Accordingly, the small container 15 may be bent, and the bent portion blocks a passage when the medicine in the small container 15 is mixed with the medicine in the storage chamber, and a part of the medicine in the small container 15 is obtained. May be difficult to mix.

  Accordingly, the present invention has been made to solve the above-described problem. The small container is easily and reliably opened, and the medicine enclosed in the small container is stored in the medicine stored in the storage chamber of the container body. It aims at providing the medical multiple-chamber container which can mix more reliably.

  The present invention has been made to solve the above-described problem, and a container main body partitioned into a plurality of storage chambers capable of storing a medicine by a weak seal portion for partitioning, and a medicine discharge attached to the container main body. And a small container that stores the medicine therein, and the weak seal portion for partitioning adheres to the opposing inner wall surfaces of the container body in a separable manner. A first fixing portion configured to be fixed to each of the opposing inner wall surfaces of the container body so that the small container is opened with the separation of the inner wall surface associated with opening of the partition weak seal portion. And a second fixed portion fixed to at least one of the opposing inner wall surfaces of the container body at a location farther from the partition weak seal portion than the first fixed portion. In providing a container That.

  The small container is sealed by sealing its peripheral edge, and the first fixing portion and the second fixing portion of the small container are heat-sealed to the container body and parallel to the partition weak seal portion. The second fixing portion may be arranged side by side on the periphery of the small container with a space therebetween.

  The first fixing portion of the small container may be fixed to the inner wall surface in the partition weak seal portion or in the storage chamber. When the small container is fixed in the storage chamber, the distance between the first fixed portion of the small container and the partition weak seal portion is preferably set to 0 to 50 mm.

It is further preferable that at least a part of the peripheral edge of the small container is sealed by thermal fusion, and the sealed portion is configured to be opened by an external force. At this time, at least one of the first adhering portion and the second adhering portion may be formed in the heat-sealed portion of the peripheral edge.
Or the 1st adhering part fixed to the inner wall face of the said storage chamber shall be formed in the non-fusion part inside a heat sealing | fusion part of the said periphery.

  The 1st adhering part of the said small container shall be comprised so that it may rank with a space | interval.

  Moreover, the said small container shall be comprised with a multilayer film and shall open with the delamination of this multilayer film.

  The medical multi-chamber container may further include a discharge sealing portion that partitions the medicine discharge portion and the storage chamber so as to be openable.

  In the present invention, since at least one end and the other end of one surface of the small container are fixed to one inner wall surface of the container main body, the drug in the small container is added to the drug in the storage chamber without bending the small container. Can be mixed more reliably.

  Hereinafter, embodiments of a medical multi-chamber container according to the present invention will be described with reference to the drawings. In the following description, the same or similar parts may be denoted by the same reference numerals throughout the plurality of embodiments, and description thereof may be omitted.

(First embodiment)
First, a first embodiment of a medical multi-chamber container according to the present invention will be described with reference to the drawings. FIG. 1 is a plan view of the medical multi-chamber container according to the first embodiment, and FIG. 2 is a cross-sectional view taken along line AA of FIG.

  As shown in FIG. 1, this medical multi-chamber container 1 is composed of a container body 5 formed in a rectangular shape by heat-sealing the peripheral edges 3 of two films, and a rubber body connected to the container body 5 inside. And a medicine discharge part 7 having a stopper. The container body 5 has a first storage chamber 9 and a second storage chamber 11 which are arranged side by side in the longitudinal direction and in which a medicine is sealed, and the two storage chambers 9 and 11 are partitioned by a partition weak seal portion 13. ing. As will be described later, a small container 15 in which a medicine is sealed is stored in the first storage chamber 9. In addition, the medicine discharge part 7 described above is connected to the second storage chamber 11, and a suspension hole 17 for hanging the container 1 is provided at the end of the container body 5 facing the medicine discharge part 7. Is formed.

  In addition, as a material of the film which comprises the container main body 5, various resin materials, such as thermoplastic resins, such as polyethylene, a polypropylene, a polystyrene, are employable. Moreover, it is not limited to a single-layer film, and a multilayer film can also be used. For example, a three-layer film in which an inner layer and an outer layer are polyolefins such as polyethylene and polypropylene and an intermediate layer is a cyclic olefin copolymer is used. can do.

  The partition weak seal portion 13 is preferably formed by heat-sealing two films of the container body 5 and extends in a direction substantially perpendicular to the longitudinal direction of the container body 5. Further, the partition weak seal portion 13 is normally fused with a strength sufficient to separate the two storage chambers 9 and 11 and to open the storage chamber by increasing the pressure in the storage chamber during use.

  Each of the storage chambers 9 and 11 is filled with various drugs a and b that need to be isolated in order to cause a change over time such as a Maillard reaction when mixed or dissolved in advance. A solution containing a reducing sugar can be stored in the other storage chamber. Moreover, an electrolyte etc. can also be enclosed in any one storage chamber as needed. In addition, not only a liquid agent but a solid chemical | medical agent can also be accommodated in any one storage chamber.

  In the illustrated example, the small container 15 is formed in a bag shape by fusing the peripheral edges of two multilayer films, and a vitamin D solution is enclosed. The multilayer film is composed of a film having a three-layer structure in which delamination easily occurs. For example, a polycyclic olefin can be sandwiched between polyethylenes. However, in addition to this, if a resin having low compatibility with other films is arranged in the intermediate layer, delamination can easily occur. For example, polypropylene is sandwiched between polyethylenes. You can also. At this time, the thickness of the innermost layer is preferably 5 to 50 μm. In addition to the vitamin D solution, the small container 15 may be powders of various drugs that are not preferably mixed directly with the drugs enclosed in the storage chambers 9 and 11, such as antibiotics, anticancer drugs, and cardiotonic drugs. A wide range of agents and liquid agents can be selected. In addition, the liquid preparation is not particularly limited, and liquids of vitamins and trace elements, dissolved solutions such as physiological saline and glucose solution, and infusion solutions can be employed.

As shown in FIG. 2A, the small container 15 is composed of multilayer films 15a and 15b, and one end portion of both sides of the small container 15 is on the outer surface of the multilayer film 15a, which is one side of the small container 15. The inner surface of the container 5 is fixed to the inner surface of the film 5a. One end portion of the outer surface of the multilayer film 15 b that is the other surface of the small container 15 is fixed to the inner surface of the film 5 b that is the other inner wall surface of the container body 5. In this way, one end portion of the small container 15 fixed to the inner surfaces of the films 5a and 5b, which are the inner wall surfaces of the container body 5 facing each other, constitutes a first fixing portion 19. The first fixing portion 19 extends in parallel with the partition weak seal portion 13 at a position about 10 mm away from the partition weak seal portion 13, and is stronger than the partition weak seal portion 13 in the same manner as the peripheral edge 3 of the container body 5. Usually, it is fused with strength that does not peel.
Further, the other end of the small container 15 that is farther from the partition weak seal portion 13 than the one end of the small container 15 is heat-sealed to the inner wall surface of the film 5a on the outer surface of the multilayer film 15a. The wearing portion forms the second fixing portion 20. This second fixing portion 20 also extends in parallel with the partition weak seal portion 13 and is fused to the extent that it is stronger than the partition weak seal portion 13 and normally does not peel off, like the peripheral edge 3 of the container body 5. Yes.

  Next, the usage method of the medical multi-chamber container comprised as mentioned above is demonstrated. In order to administer the medicine in the multi-chamber container 1 to the patient, first, the first or second storage chamber 9, 11 is pressed by hand or the like to increase the pressure in the storage chamber. Thereby, the weak seal part 13 for a partition is opened, the 1st and 2nd storage chambers 9 and 11 are connected, and the chemical | medical agent in each storage chamber 9 and 11 is mixed. At this time, opening of the partition weak seal portion 13 is performed by separating the films 5a and 5b of the container body 5, and accordingly, the small container 15 is opened.

  That is, as shown in FIG. 2 (b), when the films 5 a and 5 b of the container body 5 are separated from each other, a force F accompanying the separation acts on the small container 15. At this time, since the two multilayer films 15a and 15b of the small container 15 are fixed to the films 5a and 5b of the container body 5 by the first fixing portion 19, the multilayer films 15a and 15b are the films 5a and 15b of the container body 5. It is separated together with 5b. As a result, any of the multilayer films 15a and 15b constituting the small container 15 causes delamination, and the multilayer film is broken accordingly. In this way, the vitamin D solution sealed in the small container 15 is mixed into the drug solution mixed as described above. Subsequently, when a puncture needle (not shown) having a conduit (not shown) connected to the rubber stopper of the medicine discharge section 7 is inserted, the mixed drug solution is administered to the patient via the conduit.

  As described above, according to this embodiment, the multilayer films 15 a and 15 b constituting the small container 15 are strongly attached to the inner wall surface of the first storage chamber 9 by the first fixing portion 19 in the vicinity of the partition weak seal portion 13. Fused. Therefore, the force F that separates the films 5a and 5b of the container body 5 when the partition weak seal portion 13 is opened can be transmitted to the small container 15 via the first fixing portion 19, and the force F reduces the force. The container 15 can be opened. Therefore, it is not necessary to open the small container 15 separately, the small container 15 can be opened easily and reliably, and the burden on the operator at the busy medical site can be reduced.

  Further, since the second fixing portion 20 is further provided, the following effects can be obtained when one of the first fixing portions 19 is removed. That is, as shown in FIG. 3B, even if the fusion strength of the small container 15 with respect to at least one of the films 5a and 5b is weak and the first fixing portion 19 is peeled off, the second fixing portion 20 is removed. Thus, since the small container 15 is fixed to the container main body 5, the small container 15 is not bent. Therefore, it is possible to prevent the problem that the small container 15 is bent and the medicine stored therein is confined and mixing is not properly performed.

  In this embodiment, the small container 15 is attached at a position 10 mm away from the partition weak seal portion 13, but the position at which the small container 15 is disposed is not limited to this, and is set to an arbitrary position. Can do. However, the distance from the partition weak seal portion 13 is 0 to 20 mm so that the force of separating the films 5a and 5b of the container body 5 can be efficiently transmitted when the partition weak seal portion 13 is opened. Is preferable, and it is more preferable in it being 3-10 mm. Further, a part of the small container 15 can be sandwiched in the partition weak seal portion 13.

  Furthermore, as shown in FIG. 4, it can also form so that the 1st adhering part 19 may be located in a line with the space | interval 19a.

  Moreover, in this embodiment, although the 1st adhering part 19 is formed in the fusion | melting part of the small container 15 periphery, since heat fusion is performed with respect to the small container 15 by doing in this way, it is double. Depending on the material of the films 15a and 15b constituting the small container 15, the strength of the periphery of the small container 15 may be reduced or the tear may be caused. For this reason, as shown in FIG. 5, the first container 19 can be fixed to the container body 5 by forming the first fixing part 19 at the inner part of the small container 15 that is not heat-sealed. Similarly, the 2nd adhering part 20 can also be formed in the part which is not heat-sealed inside from the small container 15 periphery.

  Further, the second fixing portion 20 of the small container 15 can be formed not only on the film 5b but also thermally fused to both inner wall surfaces of the films 5a and 5b.

  Moreover, in this embodiment, although the 2nd adhering part 20 is formed on the periphery of the small container 15 on the straight line, as shown in FIG. It can also be formed so that they are lined up. By forming the second fixing portion 20 in this way, the medicine in the small container 15 can be more easily and reliably mixed with the medicine in the storage chambers 9 and 11.

  That is, as described in the above embodiment, when at least one of the storage chambers 9 and 11 is pressed, the small container 15 is opened from the first fixing portion 19 side. The medicine in the storage chambers 9 and 11 flows into the small container 15 from the opened portion. Here, the peripheral edge of the small container 15 corresponding to the portion where the second fixing portion 20 is formed is an interval at which the second fixing portion 20 is not formed by heat applied when the second fixing portion 20 is formed by thermal fusion. Compared to the periphery of the small container 15 corresponding to 20a, the fusion strength between the films 15a and 15b is strong. Therefore, the fluid pressure due to the force of the medicine that has flowed in is concentrated on the peripheral edge corresponding to the interval 20a where the fusion strength is weak, so that the peripheral edge is opened and the medicine in the small container 15 is stored in the storage chambers 9 and 11. More mixed with the drugs inside. Furthermore, since the periphery of the small container 15 corresponding to the interval 20a is opened, there is also an effect that it is easy to remove the air accumulated in the small container 15. In addition, it is preferable that the space | interval 20a of the 2nd adhering part 20 shall be 5-95% of the width | variety of the small container 15, and it is more preferable to set it as 50-95%.

  By the way, such a multi-chamber container 1 is usually folded in two and accommodated in a storage bag and transported. Therefore, when the first fixing portion 19 for fusing and fixing the small container 15 is provided at a predetermined position, The effect of can be obtained. That is, as shown in FIG. 7, the first fixing portion 19 is provided in parallel with the partition weak seal portion 13. For this reason, when the first storage chamber 9 is placed on the top and the first fixing portion 19 is arranged at the end of the container 1 as a double fold, the first storage chamber 9 is pressed. Even if the pressure in the storage chamber 9 increases, the force acting on the partition weak seal portion 13 side by this pressure is blocked by the first fixing portion 19. In addition, the container main body 5 can be prevented from bulging in the vicinity of the first fixing portion 19 by folding the first fixing portion 19 in two. Therefore, even if the storage chamber in which the small container 15 is disposed is pressed during transportation, it is possible to prevent the partition weak seal portion 13 from being opened.

  However, if the first fixing portion 19 is a crease, a force due to the film being broken may act and the first fixing portion 19 may be broken. Therefore, for example, when the container is folded in two along the line L shown in FIG. 5, that is, along the upper edge of the first fixing portion 19, the above-described effect is obtained while reliably preventing the first fixing portion 19 from being broken. Can be obtained. In FIG. 7, one multi-chamber container 1 is housed in one housing bag F, but two or more multi-chamber containers 1 may be housed.

  In this embodiment, the small container 15 is composed of the multilayer films 15a and 15b and is opened using delamination. However, the container body 5 is formed as follows using the single-layer films 15a and 15b. It can also be attached. That is, as shown in FIG. 8A, a part of the periphery of the small container 15 is configured to be openable by a weak seal portion 21 by heat fusion or the like, and films 15a and 15b constituting the weak seal portion 21 are formed. The first fixing portion 23 is formed by heat-sealing the outer surface of the first housing chamber 9 to the inner wall surface of the first storage chamber 9. At this time, heat fusion of the first fixing portion 23 acts on the weak seal portion 21 so that the opening strength of the weak seal portion 21 does not increase. That is, only the outer surface of the weak seal portion 21 is heat-sealed to the inner wall surface of the first storage chamber 9. Even with this configuration, as shown in FIG. 8 (b), the weak seal portion 21 of the small container 15 is also opened with the opening of the weak seal portion 13 for partitioning, so that the chemical solution in the small container 15 is mixed. Therefore, the operation can be performed easily and reliably. However, from the viewpoint of easy production, it is preferable to use a multilayer film. This is because when a multilayer film is used, heat fusion can be performed strongly over the entire thickness direction of the film of the small container 15 so that delamination can occur.

  The medical multi-chamber container as described above can be manufactured by various manufacturing methods. For example, the following method can be shown as an example.

  As shown in FIG. 9, first, both sides of the container body periphery are strongly heat-sealed to form a strong seal portion 3a, and a partition weak seal portion 13 connecting the strong seal portions 3a is formed ( FIG. 9A). Subsequently, the small container 15 enclosing the chemical solution is disposed in the upper storage chamber, that is, the first storage chamber 9. At this time, the small container 15 is arranged in the vicinity of the partition weak seal portion 13 (FIG. 9B). And the 1st adhering part 19 is formed inside the weak seal part 13 side periphery of the small container 15 further, and also the 2nd adhering part inside the periphery on the opposite side to the location where the 1st adhering part 19 is formed. 20 is formed, and the small container 15 is fixed to the film constituting the container body 5. (FIG. 9 (c)). At this time, the 1st adhering part 19 and the 2nd adhering part 20 can also be formed in the periphery of the small container 15, ie, the part currently heat-sealed. And after inject | pouring a chemical | medical solution into the 1st storage chamber 9 from opening of the container main body upper end part (FIG.9 (d)), the upper end part 3b of the container main body 5 is heat-sealed, and the 1st storage chamber 9 is sealed. (FIG. 9 (e)).

  Moreover, as shown in FIG. 10, a port part is provided in the upper end part of the container main body 5, and a chemical | medical solution can also be inject | poured from here. That is, similarly to the above, after forming the strong seal portion 3a and the partition weak seal portion 13 on both sides of the container body (FIG. 10A), the small container 15 is disposed in the first storage chamber 9 (FIG. 10 (b)), the small container 15 is fixed by the first fixing portion 19 and the second fixing portion 20, and the upper end portion 3b of the container body 5 is heat-sealed except for the insertion portion of the port portion (FIG. 10 (10)). c)). Subsequently, the port portion 16 is inserted into the non-fused portion of the container body upper end portion 3b, and the port portion 16 and the container body upper end portion 3b are fixed by heat fusion (FIG. 10D). And after inject | pouring a chemical | medical solution into the 1st storage chamber 9 via the port part 16 (FIG.10 (e)), the stopper 16a is made to the port part 16 (FIG.10 (f)). In addition, it can also manufacture by inject | pouring a chemical | medical solution from a non-fusion | fusion part, without attaching a port part, and melt | fusing and sealing this part.

  About the 2nd storage chamber 11 in each said example, injection | pouring of a chemical | medical solution and attachment of the chemical | medical agent discharge part 7 can be performed like FIG.10 (c)-FIG.10 (f), for example.

(Second Embodiment)
Next, a second embodiment according to the medical multi-chamber container of the present invention will be described. The second embodiment is different from the first embodiment in that a discharge weak seal portion described below is provided, and other configurations are the same as those in the first embodiment. Detailed description is omitted.

  As shown in FIG. 11, the medical multi-chamber container 1 according to this embodiment includes a discharge weak seal portion (discharge seal portion) 25 that partitions the second storage chamber 11 and the drug discharge portion 7. ing. The discharge weak seal portion 25 is formed in an arc shape so as to surround one end of the discharge portion 7, and is fused with substantially the same strength as the partition weak seal portion 13. The shape of the discharge weak seal portion 25 may be other than a circular arc, and the shape is not particularly limited as long as the second storage chamber 11 and the discharge portion 7 are partitioned.

  When the multi-chamber container 1 is used, first, the partitioning weak seal portion 13 is opened, and the small container 15 is opened accordingly, and the chemical solution is mixed. Next, when the discharge weak seal portion 25 is opened and subsequently a puncture needle is inserted into the drug discharge portion 7, the mixed drug solution is discharged from the discharge portion 7.

  The following effects can be obtained by providing the discharge weak seal portion as described above. That is, conventionally, if the piercing needle is mistakenly inserted into the discharge portion 7 before opening the weak seal portion 13 for partitioning, the chemical solution in the second storage chamber 11 before mixing may be discharged from the discharge portion 7. was there. On the other hand, when the discharge weak seal portion 25 is provided, the chemical solution in the second storage chamber 11 is discharged even when the piercing needle is inserted before the partition weak seal portion 13 is opened. It is blocked by the weak seal portion 25 and is not discharged from the discharge portion 7. Therefore, since the medicine is not discharged in this way, it is possible to alert the operator to the correct usage method, and it is possible to reliably discharge only the mixed chemical liquid.

  The opening strength of the partition weak seal portion 13 and the discharge weak seal portion 25 may not be the same, and either one may be weaker than the other. Thus, in order to make any one easier to open than the other, for example, it is preferable to provide a protruding portion on a part of one weak seal portion. As shown in FIG. 12A, in this example, a protruding portion 27 formed in a V shape is provided in the middle of the partition weak seal portion 13. And as shown in FIG.12 (b), when the 2nd storage chamber 11 is pressed and the internal pressure is raised, a pressure will act on the weak seal part 13 in the direction of the arrow in a figure. At this time, since the pressure acts perpendicularly and equally to the weak seal portion 13, the total pressure acting on the region in the vicinity of the top portion C of the protruding portion 27 becomes higher than the other regions of the weak seal portion 13.

  Thus, as shown in FIG. 12 (b), this pressure acts in the direction of separating the films constituting the container body 5, and when the pressure in the storage chamber 11 is further increased, the partition weak seal portion 13 protrudes. Peeling starts from the top C of the portion 27. As a result, peeling progresses rapidly under the action of pressure, and the partition weak seal portion 13 is opened prior to the discharge weak seal portion 25, whereby the first storage chamber 9 and the second storage chamber 11 are separated. The drug is mixed in communication. At this time, although not shown, the small container 15 is also opened at the same time.

  When the protruding portion 27 as described above is provided, the widths of the two weak seal portions 13 and 25 are made the same, and further the opening strength of the weak seal portions 13 and 25 is made different while keeping the same fusion strength. Can do. Therefore, it is not necessary to adjust the fusion time or the like, and both weak seal portions 13 and 25 can be fused under the same conditions. As a result, the manufacturing time of the container 1 can be shortened and the manufacturing cost can be reduced.

  In addition to providing the discharge weak seal portion 25 as described above, for example, a sealing portion for closing the discharge portion 7 is provided on the second storage chamber 11 side of the discharge portion 7 so that pressure or the like does not act from the outside. In addition, the chemical solution in the second storage chamber 11 may be configured not to reach the discharge unit 7. Even if it does in this way, it can prevent that the chemical | medical solution in the 2nd storage chamber 11 is discharged | emitted even if a piercing needle is inserted in a rubber stopper while the sealing part is not opened.

(Third embodiment)
Next, a third embodiment according to the medical multi-chamber container of the present invention will be described. This embodiment is different from the first embodiment in that only a small container is stored in the storage chamber and no medicine is directly stored. Since other configurations are the same as those of the first embodiment, detailed description thereof is omitted.

  As shown in FIG. 13, in the medical multi-chamber container according to this embodiment, only the small container 15 is stored in the first storage chamber 9, and no medicine is stored. On the other hand, the liquid medicine b is directly stored in the second storage chamber 11 as in the above embodiments. Thus, in this embodiment, the medicine a is stored in the first storage chamber 9 by storing the small container 15 in which the medicine a is enclosed, instead of directly storing the medicine in the first storage chamber 9. I am going to do that. This has the following advantages.

  First, when the amount of medicine to be stored in the first storage chamber 9 is changed, it is possible to cope with this by changing only the size of the small container 15 without changing the size of the container body 5. For example, when the amount of medicine stored in the first storage chamber 9 is very small compared to the size of the storage chamber, the drug is easily dispersed, so that the chemical solution b in the second storage chamber 11 is transferred to the first storage chamber. It is difficult to mix the two unless they reach almost the whole of 9. On the other hand, if the small container 15 is miniaturized according to the amount of the medicine a, the medicine can be held in a concentrated state without being dispersed. Therefore, when the partition weak seal portion 13 and the small container 15 are opened, the medicine a in the small container 15 and the chemical liquid b in the second storage chamber 11 can be reliably mixed.

  There are also the following advantages. For example, when the medicine a to be stored in the first storage chamber 9 is adsorbed to the synthetic resin or has a light deterioration property, the first storage chamber 9, that is, the film constituting the container body 5 is soiled or deteriorates. There is. In such a case, the film constituting the small container 15 is made of a material that hardly absorbs the medicine, or made of a material that has little light deterioration, and is stored in the first storage chamber 9. In this way, since only the small container 15 needs to be accommodated, it is not necessary to change the material of the entire container body 3 according to the drug. Therefore, the cost can be reduced when using the medicine as described above.

  Furthermore, since the small container 15 can be manufactured separately from the container main body 5, the sterilization method in which the drug a stored in the small container 15 and the drug b stored in the second storage chamber 11 of the container main body 5 are different. Even if it is necessary to sterilize by the above, it is not necessary to provide the two types of sterilization facilities in the production facility of the container body 5. That is, since the medicine a in the small container 15 only needs to be sterilized by equipment for manufacturing the small container 15, the manufacturing equipment for the container body 5 can be provided with only equipment for sterilizing the medicine in the second storage chamber 11, Simplification of manufacturing equipment can be achieved.

  In the above description, the small container 15 is stored in the first storage chamber 9, but the small container 15 may be stored in the second storage chamber 11 as shown in FIG. 14. In this case, there are the following advantages. As shown in the figure, the second storage chamber 11 does not store the medicine directly, but stores only the small container 15. Therefore, for example, even when a puncture needle is inserted into the medicine discharge section 7 before the partition weak seal section 13 is opened, the medicine is not discharged. Therefore, the medicine before mixing is prevented from being discharged. Moreover, by comprising in this way, discharge | emission of the chemical | medical agent before mixing can be prevented even if it does not provide the weak seal part 25 for discharge | emission shown in 2nd Embodiment.

  As another aspect, the medicine and the small container 15 can be stored in the first storage chamber 9, and the second storage chamber 11 can be made empty. If comprised in this way, the small container 15 can be easily opened, and it is also possible to prevent the discharge of the drug before mixing as described above.

  As mentioned above, although embodiment of this invention was described, this invention is not limited to these, A various change is possible unless it deviates from the meaning of this invention.

  For example, if the small container is configured as follows, it can be more easily opened. That is, as shown in FIG. 15A, when a plurality of cuts 18 are formed at the lower edge of the small container 15, the force separating the sheets of the small container 15 is transmitted to the peripheral edge of the small container 15 through the cuts 18. The peripheral edge is likely to be broken along the line S in FIG. Therefore, in addition to the delamination of the sheet, the peripheral edge is easily broken, so that the small container 15 can be opened more easily. Also, as shown in FIG. 15B, the same effect can be obtained even if the lower edge 15a of the small container 15 is formed in a saw blade shape. Alternatively, as shown in FIG. 15 (c), if the film constituting the small container 15 is produced by stretching in the X direction in the figure, the film is easily torn along the X direction. The container 15 can be easily opened. In addition, if it is a film which is easy to tear along a X direction, the film manufactured by methods other than extending | stretching can also be used. Moreover, as shown in FIG. 16, a saw blade shape can be provided inside the periphery of the small container.

  In addition, in order to make it easier to open the small container 15, the above-mentioned thing can also be combined suitably. That is, any two or all of those shown in FIGS. 15A to 15C can be combined.

  Moreover, in the said embodiment, although the partition weak seal part 13 and the discharge | emission weak seal part 25 are comprised by the heat sealing | fusion of the film, it is not limited to this, It opens by the effect | action of the force from the outside. If it does, a various aspect can be taken. For example, it can also comprise by providing a convex strip part and a concave strip part in each film surface which the container main body 5 opposes, and making these concavo-convex fitting so that these are detachable. Alternatively, a partitioning film having a part thinner than the other part can be provided, and when the pressure is applied, the thin part can be broken so that the two storage chambers communicate with each other. In this case, if the small container 15 is fixed in the vicinity of the membrane, the small container 15 can be opened along with the separation of the film of the container body 5 when the storage chambers 9 and 11 communicate with each other.

  Even if the first fixing portion 19 that fixes the small container 15 to the film of the container body 5 is not parallel to the partition weak seal portion 13 as described above, the force F accompanying the separation of the film of the container body 5 is applied. The shape is not particularly limited as long as it can be transmitted to the small container 15. Moreover, even if it is other than heat sealing | fusion, if it can fix to the container main body 5 reliably, the structure will not be specifically limited. Further, the second fixing portion 20 does not need to be parallel to the partition weak seal portion 13, and a part of the small container 15 is fixed to the container body 5 so that the small container 15 is not bent in the container body 5. For example, as shown in FIG. 17, it may be formed in a direction perpendicular to the partition weak seal portion 13.

  In the above embodiment, the first fixing portion 19 of the small container 15 is fixed to the inner wall surface of the container body 5 in the first storage chamber 9 or the second storage chamber 11. As shown in FIG. 18, it can be fixed in the partition weak seal portion 13.

  Further, the small container 15 is configured to be opened with the separation of the film of the container main body 5 even if the small container 15 is formed of a multilayer film as described above or a part of the periphery is formed of a weak seal portion. For example, the entire small container 15 can be made of a thin film that is easy to break.

  The number of small containers 15 is not limited to one, and two or more small containers 15 can be provided, and the storage chamber in which the small containers are arranged is not limited to the first storage chamber 9 as described above, but also the second storage chamber 11. It can also be arranged. Further, the small container 15 itself may have a plurality of chambers partitioned by partition walls.

  Further, the number of storage chambers is not limited to two as described above, but may be three or more. In this case, each storage chamber is partitioned by the above-described weak sealing portion for partitioning. Just do it. And the small container should just be arrange | positioned in the above aspects in at least 1 storage chamber.

  In the above example, the weak seal portion for partitioning each storage chamber is a weak seal portion by heat fusion of the film surface, but instead, the direction in which the opposing films of the container body are separated. Moreover, it can be set as a strong seal | sticker of the grade which can be opened by pulling each film. Even in that case, the effect of opening the small container with the opening of the strong seal remains unchanged.

It is a top view which shows 1st Embodiment of the medical multi-chamber container which concerns on this invention. It is the sectional view on the AA line of FIG. It is sectional drawing which shows the prior art example (a) and the present Example (b) when the 1st adhering part 19 remove | deviates. It is a top view which shows the other example of the medical multiple chamber container of FIG. It is a top view which shows the other example of the medical multiple chamber container of FIG. It is a top view which shows the other example of the medical multiple chamber container of FIG. It is sectional drawing which shows the state which folded the medical multiple chamber container of FIG. 1 into two. It is principal part sectional drawing which shows the other example of the medical multiple chamber container of FIG. It is a figure which shows the example of the manufacturing method of the medical multi-chamber container which concerns on this invention. It is a figure which shows the example of the manufacturing method of the medical multi-chamber container which concerns on this invention. It is a top view which shows 2nd Embodiment of the medical multi-chamber container which concerns on this invention. It is a principal part top view and sectional drawing which show the other example of the medical multiple chamber container of FIG. It is a top view which shows 3rd Embodiment of the medical multi-chamber container which concerns on this invention. It is a top view which shows the other example of 3rd Embodiment of the medical multiple chamber container which concerns on this invention. It is a figure which shows the other example of the small container used for the medical multi-chamber container which concerns on this invention. It is a figure which shows the other example of the small container used for the medical multi-chamber container which concerns on this invention. It is a top view which shows the other example of a small container used for the medical multi-chamber container which concerns on this invention. It is the top view (a) and sectional drawing (b) which show the other fixed example of the small container used for the medical multiple-chamber container which concerns on this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical multiple-chamber container 5 Container main body 7 Drug discharge | emission part 9 1st storage chamber 11 2nd storage chamber 13 Weak seal part 15 for partitions Small container 19 1st adhering part 19a space | interval 20 2nd adhering part 20a space | interval

Claims (10)

A container main body partitioned into a plurality of storage chambers capable of storing a drug by a partition weak seal;
A medicine discharge part attached to the container body;
A small container which is stored in at least one of the storage chambers and stores a medicine therein,
The partition weak seal portion is configured by fixing the opposing inner wall surfaces of the container body so as to be separable,
The small container is opened with the separation of the inner wall surface with the opening of the partition weak seal portion,
A first fixing portion that is fixed to each of the opposing inner wall surfaces of the container body in the storage chamber, and extends in parallel with the partition weak seal portion ;
At a location remote from the partitioning weak seal portion than the first fixing part, I have a, a second fixing portion that is fixed to at least one of the opposing inner wall surface of the container body,
A medical multi-chamber container , wherein a distance between the first fixing part of the small container and the weak seal part for partitioning is 0 to 50 mm . The small container has its periphery fused and sealed,
The first fixing part and the second fixing part of the small container are heat-sealed to the container body ,
The second fixing portion extends in parallel with the partition weak seal portion,
2. The medical multi-chamber container according to claim 1, wherein the second fixing portion is arranged in parallel on the periphery of the small container at an interval. The medical multi-chamber container according to claim 1 or 2 , wherein at least a part of a peripheral edge of the small container is sealed by heat fusion, and the sealed portion is configured to be opened by an external force. 4. The medical multi-chamber container according to claim 3 , wherein at least one of the first fixing portion and the second fixing portion is formed in a heat-sealed portion of the peripheral edge. The medical multi-chamber container according to claim 3 , wherein a first fixing portion that is fixed to the inner wall surface of the storage chamber is formed in a non-fusion portion inside the peripheral heat-sealing portion. The medical multi-chamber container according to any one of claims 1 to 5 , wherein the first fixing portions of the small container are configured to be arranged at intervals. The medical multi-chamber container according to any one of claims 1 to 6 , wherein the small container is formed of a multilayer film and is opened with delamination of the multilayer film. The medical multi-chamber container according to any one of claims 1 to 7 , wherein the medicine discharge section is connected to a storage chamber in which the small container is stored. The medical multi-chamber container according to any one of claims 1 to 8 , further comprising a discharge sealing portion that partitions the medicine discharge portion and the storage chamber in an openable manner. The medical multi-chamber container according to any one of claims 1 to 9 , wherein a medicine selected from antibiotics, anticancer agents, cardiotonic agents, vitamins, or trace elements is stored in the small container.

Images