WO2009130997A1 - 高純度トリメリット酸の製造法 - Google Patents
高純度トリメリット酸の製造法 Download PDFInfo
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- WO2009130997A1 WO2009130997A1 PCT/JP2009/057119 JP2009057119W WO2009130997A1 WO 2009130997 A1 WO2009130997 A1 WO 2009130997A1 JP 2009057119 W JP2009057119 W JP 2009057119W WO 2009130997 A1 WO2009130997 A1 WO 2009130997A1
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- mass
- acid
- dimethylbenzaldehyde
- catalyst
- trimellitic acid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/128—Halogens; Compounds thereof with iron group metals or platinum group metals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
- C07C51/255—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of compounds containing six-membered aromatic rings without ring-splitting
- C07C51/265—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of compounds containing six-membered aromatic rings without ring-splitting having alkyl side chains which are oxidised to carboxyl groups
Definitions
- the present invention relates to a method for industrially advantageously producing trimellitic acid from dimethylbenzaldehyde and / or an oxidized derivative thereof by continuous liquid phase air oxidation with high yield and high quality.
- trimellitic acid has been known to be produced by subjecting pseudocumene to air oxidation in an acetic acid solvent using a cobalt-manganese-bromine catalyst (Patent Document 1).
- the pseudocumene used as the oxidation raw material is changed to 2,4-dimethylbenzaldehyde or 2,4-dimethylbenzoic acid, and a metal selected from manganese and cerium is used for liquid phase oxidation using molecular oxygen in an aqueous solvent.
- a method using a bromine compound as a catalyst is known (Patent Document 2).
- Patent Document 3 discloses 2,4-dimethylbenzaldehyde, 2,5-dimethylbenzaldehyde, 3,4-dimethylbenzaldehyde, 2,4-dimethylbenzoic acid, 2,5-dimethylbenzoic acid and / or 3,4.
- -A method for producing trimellitic acid by liquid phase oxidation with molecular oxygen in two steps in the presence of bromine or a bromine and heavy metal catalyst in an aqueous solvent using dimethylbenzoic acid as a raw material is disclosed.
- trimellitic acid is produced from 2,4-dimethylbenzaldehyde using a catalyst composed of manganese and bromine in an aqueous solvent.
- trimellitic acid is produced continuously and bromine is added to the second stage to reduce the amount of organic bromine compound by-product.
- the by-product of organic bromine compound is a catalyst component. It is desirable to further reduce the amount of by-produced organic bromine compounds because it results in loss of bromine components.
- An object of the present invention is to provide a method for industrially producing high-quality high-purity trimellitic acid using dimethylbenzaldehyde and / or an oxidized derivative thereof as a raw material.
- this invention provides the manufacturing method of the following high purity trimellitic acids.
- a method for producing trimellitic acid by liquid phase oxidation of dimethylbenzaldehyde and / or an oxidized derivative thereof with molecular oxygen in an aqueous solvent containing a catalyst 3,4-dimethylbenzaldehyde and / or 3,4
- 4-dimethylbenzoic acid as a catalyst, 0.05 to 1 part by weight of one or more metals selected from the group consisting of cobalt, manganese and nickel, metallic iron and / or water based on 100 parts by weight of an aqueous solvent
- High-purity trimerit characterized by liquid phase oxidation at a temperature of 200 to 250 ° C.
- trimellitic acid can be obtained in high yield. Further, since the residual ratio of bromine used as the catalyst is high, the amount of bromine replenished when the catalyst is circulated and reused is reduced, and the manufacturing cost is reduced. Furthermore, this reduces the discharge amount of by-products such as organic bromine compounds discharged in the refining process, thereby reducing the wastewater treatment load. Therefore, according to the method of the present invention, high-purity trimellitic acid can be produced industrially advantageously.
- Dimethylbenzaldehyde which is a raw material for trimellitic acid production by liquid phase oxidation and its oxidation reaction derivative include 2,4-dimethylbenzaldehyde, 2,5-dimethylbenzaldehyde, 3,4-dimethylbenzaldehyde and 2,4-dimethylbenzoic acid.
- 2,4-dimethylbenzaldehyde 2,5-dimethylbenzaldehyde, 3,4-dimethylbenzaldehyde and 2,4-dimethylbenzoic acid.
- 2,4-dimethylbenzaldehyde has been mainly used.
- 3,4-dimethylbenzaldehyde and / or 3,4-dimethylbenzoic acid is used as a raw material.
- the production method of the present invention is a method of producing trimellitic acid using air as an oxidant and water as a solvent, using a conventional catalyst in which iron is added, and is produced in a continuous manner. Can do.
- the raw materials 3,4-dimethylbenzaldehyde and 3,4-dimethylbenzoic acid can be used alone or as a mixture.
- one or more metals selected from the group consisting of cobalt, manganese and nickel are used, and manganese is particularly preferable.
- These compounds containing metals can be used alone or in a mixture.
- the compound containing these metals may be used in any form, and may be an organic salt or an inorganic salt, but is desirably present as an ion in an aqueous solvent, more preferably a bromide salt, specifically Specifically, they are cobalt bromide, manganese bromide, and nickel bromide.
- the bromine used for the catalyst is preferably an inorganic bromine compound that generates bromide ions, and the metal bromide salts as described above can be used, but hydrobromic acid is more preferably used.
- the content of the metal selected from the group consisting of cobalt, manganese and nickel is 0.05 to 1 part by mass, preferably 0.1 to 0.5 part by mass, with respect to 100 parts by mass of the aqueous solvent.
- the bromine content is 1 to 5 parts by mass, preferably 1.5 to 4 parts by mass with respect to 100 parts by mass of the aqueous solvent.
- the iron added as a catalyst in the aqueous solvent is metallic iron and / or a water-soluble iron salt.
- the water-soluble iron salt may be an organic salt or an inorganic salt, but is preferably present as an ion in an aqueous solvent.
- ferric acetate, ferrous halide, ferric halide, ferrous sulfate, ferric sulfate, ferrous nitrate, ferric nitrate and hydrated salts thereof can be used.
- Ferric bromide is preferred.
- These metallic irons and / or water-soluble iron salts may be used alone or in combination of two or more, and include metallic iron ions eluted from the metal pipe.
- the iron content is 0.0001 to 0.0015 parts by mass, preferably 0.0002 to 0.0010 parts by mass with respect to 100 parts by mass of the aqueous solvent.
- the liquid phase oxidation method is preferably a continuous method, but a multi-stage continuous method is preferable, and a two-stage continuous method is more preferable.
- the reactor 1 and the reactor 2 are connected in series, and an oxidation raw material, a catalyst-containing solvent, and air are added from the inlet of the reactor 1 to perform a liquid-phase oxidation reaction.
- the liquid is fed to the inlet of the reactor 2 and further air is added in the reactor 2 to perform a liquid phase oxidation reaction.
- bromine addition is preferably divided into two stages, and 5 to 50% by mass of the total bromine amount is preferably added to the reactor 2 in the second stage.
- the water used for the solvent is preferably distilled water, ion-exchanged water, membrane-filtered water, or the like, more preferably water obtained with a polisher-equipped pure water production apparatus.
- the amount of the aqueous solvent used is preferably 1 to 8 times in terms of mass ratio with respect to 3,4-dimethylbenzaldehyde and / or 3,4-dimethylbenzoic acid as raw materials. A range is more preferred.
- the reaction temperature is 200 to 250 ° C, preferably 210 to 230 ° C.
- the reaction temperature of each stage in the multistage continuous system can be selected within the temperature range.
- the reaction pressure is not particularly limited as long as the reaction liquid can be kept in a liquid phase, but is usually in the range of 1.6 to 6 MPa.
- the reaction pressure of each stage in the multistage continuous system can be selected within the pressure range.
- the process for producing trimellitic acid according to the present invention is particularly based on 3,4-dimethylbenzaldehyde and / or 3,4-dimethylbenzoic acid, and the bromide ion residual ratio of the bromine compound used as a catalyst is high.
- the bromide ion residual rate mentioned here is a ratio in which bromine provided as a catalyst (in the form bromide ions) remains in the form of bromide ions in an aqueous solvent without becoming an organic bromine compound as a reaction byproduct. .
- Bromide ions are not only a catalyst but also a reactant, and bromide ions subjected to the reaction remain in a certain proportion in the organic bromine compound and the rest in the aqueous solvent as a catalyst having oxidation activity.
- the proportion of bromide ions remaining in the aqueous solvent is high, when the aqueous solvent is recycled to the reaction, the remaining bromide ions function as a catalyst, so that the amount of bromide ions to be newly added may be small. That is, it can be said that a high ratio of bromide ions remaining in the aqueous solvent after the reaction, that is, a high residual ratio of bromide ions, indicates a high ratio of bromine used as a catalyst.
- the bromide ion residual ratio when the bromide ion residual ratio is compared, when 3,4-dimethylbenzaldehyde and / or 3,4-dimethylbenzoic acid is used as a raw material, 2,4-dimethylbenzaldehyde and / or 2,4-dimethyl is used. Compared with benzoic acid as a raw material, the bromide ion residual rate is remarkably high and there are also few organic bromine compounds. Accordingly, since the ratio of bromide ions that can be reused as a catalyst is high, the replenishment amount of the bromine compound can be reduced when the catalyst solution is reused, and high-purity trimellitic acid can be produced advantageously in terms of cost.
- the production of other impurities can be reduced at the same time as the amount of by-produced organic bromine compound, so that high-quality trimellitic acid excellent in purity, impurity composition, etc. can be produced. .
- the bromide ion residual rate of the bromine compound used for a catalyst can be made high, highly purified trimellitic acid can be manufactured advantageously in terms of cost. Furthermore, this reduces the amount of by-products such as organic bromine compounds discharged in the purification process, which reduces the wastewater treatment load and is an excellent method from the viewpoint of environmental problems.
- reaction products were analyzed using a gas chromatography apparatus (GC apparatus) under the following conditions.
- Detector Hydrogen flame ionization detector (FID) Analysis method: 1 g of the reaction solution is accurately collected and collected in a heat-resistant glass test tube, diluted with 3 g of methanol, and further added with 3 g of triethylamine hydrochloride and 10 ml of trimethyl phosphate. The mixed solution is subjected to methyl esterification treatment by heating at 180 ° C. for 40 minutes. After the treatment liquid is cooled to room temperature, 20 ml of chloroform is added to the liquid, and 0.1 g of triphenylmethane, which is an internal standard substance for GC analysis, is thoroughly added and dissolved uniformly.
- FID Hydrogen flame ionization detector
- Pure water is added to make the liquid in the beaker about 150 ml, and about 2 ml of 60% by mass nitric acid is added. Precipitation titration is performed with the above automatic titrator to determine bromide ion concentration.
- Example 1 Using a continuous two-stage reactor connected to two 2 L zirconium oxidation reactors equipped with a reflux condenser, a stirring device, a heating device, a raw material inlet, a gas inlet, and a reactant outlet, Liquid phase air oxidation of 4-dimethylbenzaldehyde (3,4-DBAL) was performed. 1422 parts by mass of water obtained by a pure water production apparatus with a polisher, 37.3 parts by mass of a hydrobromic acid aqueous solution (reagent: manufactured by Wako Pure Chemical Industries, Ltd., HBr 47.0-49.0% by mass), MnBr 2.
- catalyst solution A 4H 2 O (reagent: manufactured by Mitsuwa Pharmaceutical Co., Ltd.) 30.5 parts by mass and 50% by mass FeBr 3 aqueous solution (reagent: manufactured by Mitsuwa Pharmaceutical Co., Ltd., Fe content: 9.4% by mass) 0.08 parts by mass Were mixed at this ratio to prepare catalyst solution A.
- 55.7 parts by mass of water and 4.3 parts by mass of a hydrobromic acid aqueous solution (reagent: manufactured by Wako Pure Chemical Industries, Ltd., HBr 47.0-49.0% by mass) were mixed at this ratio to obtain catalyst solution B was prepared.
- trimellitic acid (TMA) was 91%, the yield of trimellitic bromide obtained by adding bromine to trimellitic acid was 0.1%, and one carboxyl group of trimellitic acid was a methyl group.
- the yield of the oxidation intermediate dicarboxymethylbenzene (2-methylterephthalic acid and 4-methylisophthalic acid: DCMB) is 0.4%, and the oxidation intermediate trimeride (1-carboxy-3,4-phthalide) And 1-carboxy-4,5-phthalide) is 1.2%.
- the yield of phthalic acid from which one carboxyl group of trimellitic acid is eliminated is 0.0%.
- the yield of pyromellitic acid (PMA) with one carboxyl group added was 0.1%. Further, the bromide ion residual ratio was 82%. The results are shown in Table 1.
- Example 2 The reaction was conducted in the same manner as in Example 1 except that the catalyst solution composition was adjusted so that the iron content was 0.0002 (2 ppm) by mass with respect to 100 parts by mass of water, and the reaction product was subjected to GC analysis. As a result, trimellitic acid 89%, trimellitic bromide 0.1%, dicarboxymethylbenzene 0.4%, trimellide 1.4%, phthalic acid 0.0%, pyromellitic acid Obtained in a yield of 0.2%. Further, the bromide ion residual ratio was 83%. The results are shown in Table 1.
- Example 3 The reaction was conducted in the same manner as in Example 1 except that the catalyst solution composition was adjusted so that the iron content was 0.001 part by mass (10 ppm) with respect to 100 parts by mass of water, and the reaction product was subjected to GC analysis.
- trimellitic acid was 92%
- trimellitic bromide was 0.1%
- dicarboxymethylbenzene was 1.1%
- trimellide was 2.0%
- phthalic acid was 0.1%
- pyromellitic acid was Obtained in a yield of 0.1%.
- the bromide ion residual ratio was 84%. The results are shown in Table 1.
- Example 4 The reaction was performed in the same manner as in Example 1 except that the temperature of each reactor was 210 ° C., and the reaction product was subjected to GC analysis. As a result, trimellitic acid 89%, trimellitic bromide 0.1%, dicarboxymethylbenzene 1.2%, trimellide 3.1%, phthalic acid 0.0%, pyromellitic acid Obtained in a yield of 0.1%. Further, the bromide ion residual ratio was 82%. The results are shown in Table 1.
- Example 5 The reaction was carried out in the same manner as in Example 1 except that the total amount of bromine was 1.5 parts by mass (10.5% by mass for the second-stage reactor), and the reaction product was subjected to GC analysis. As a result, trimellitic acid was 91%, trimellitic bromide was 0.1%, dicarboxymethylbenzene was 0.9%, trimellide was 1.8%, phthalic acid was 0.0%, pyromellitic acid was Obtained in a yield of 0.2%. Further, the bromide ion residual ratio was 79%. The results are shown in Table 1.
- Example 6 The reaction was conducted in the same manner as in Example 1 except that 3,4-dimethylbenzoic acid (3,4-DBA) was used in place of the raw material 3,4-dimethylbenzaldehyde, and the reaction product was subjected to GC analysis. As a result, 93% trimellitic acid, 0.1% trimellitic bromide, 0.4% dicarboxymethylbenzene, 1.5% trimellid, 0.0% phthalic acid, pyromellitic acid Obtained in a yield of 0.1%. Further, the bromide ion residual ratio was 86%. The results are shown in Table 1.
- Comparative Example 1 The reaction was carried out in the same manner as in Example 4 except that 50% by mass FeBr 3 aqueous solution was not used, and the reaction product was subjected to GC analysis. As a result, trimellitic acid is 66%, trimellitic bromide is 0.2%, dicarboxymethylbenzene is 0.8%, trimellide is 4.4%, phthalic acid is 0.1%, pyromellitic acid is Obtained in a yield of 0.1%. Further, the bromide ion residual ratio was 74%. The results are shown in Table 2.
- Comparative Example 2 The reaction was performed in the same manner as in Example 4 except that the catalyst solution composition was adjusted so that the iron content was 0.0020 parts by mass (20 ppm) with respect to 100 parts by mass of water, and the reaction product was subjected to GC analysis. As a result, 86% trimellitic acid, 0.1% trimellitic bromide, 1.4% dicarboxymethylbenzene, 3.9% trimellid, 0.1% phthalic acid, pyromellitic acid Obtained in a yield of 0.4%. Further, the bromide ion residual ratio was 76%. The results are shown in Table 2.
- Comparative Example 4 The reaction was carried out in the same manner as in Example 3 except that 2,4-dimethylbenzaldehyde was used as the oxidation raw material, and the reaction product was subjected to GC analysis. As a result, trimellitic acid was 83%, trimellitic bromide was 0.9%, dicarboxymethylbenzene was 0.7%, trimellide was 2.0%, phthalic acid was 0.0%, pyromellitic acid was Obtained in a yield of 0.2%. Further, the bromide ion residual ratio was 34%. The results are shown in Table 2.
- Comparative Example 5 Liquid phase air oxidation was carried out in the same manner as in Comparative Example 3 except that the 50 mass% FeBr 3 aqueous solution was not used. As a result, trimellitic acid was 91%, trimellitic bromide was 0.8%, dicarboxymethylbenzene was 0.4%, trimellide was 2.1%, phthalic acid was 0.1%, pyromellitic acid was Obtained in a yield of 0.1%. Further, the bromide ion residual ratio was 56%. The results are shown in Table 2.
- the starting material 3,4-DBAL is 3,4-dimethylbenzaldehyde
- 2,4-DBAL is 2,4-dimethylbenzaldehyde
- 3,4-DBA is 3,4-dimethyl.
- the catalyst component concentration is the catalyst component mass per 100 parts by mass of the water solvent
- the yield of trimellitic acid is the molar ratio (%) of trimellitic acid obtained with respect to the raw material
- the bromide ion residual rate is As described above, it is the molar ratio (%) of bromide ions in the reaction product solution to bromine (bromide ions) supplied as a catalyst component.
- One trimeride, 1-carboxy-3,4-phthalide is a compound represented by the chemical structural formula on the right.
- the bromide ion residual ratio is as high as about 80%, which is advantageous in terms of cost. Trimellitic acid can be produced.
- trimellitic acid bromide which is an organic bromine compound produced when 2,4-dimethylbenzaldehyde and / or 2,4-dimethylbenzoic acid, which are conventional raw materials, are used.
- trimellitic acid bromide is 0.11 to 0.125 ( 1/9 to 1/8).
- trimeride which is an oxidation reaction intermediate produced when using 2,4-dimethylbenzaldehyde and / or 2,4-dimethylbenzoic acid, which are conventional raw materials
- amount of trimeride is 1,
- 1,4-dimethylbenzaldehyde and / or 3,4-dimethylbenzoic acid is used as a raw material, the amount is 0.5 to 1 (1/2 to 1/1).
- the reduction in the amount of phthalic acid produced leads to a reduction in the production of dioctyl phthalate: DOP when esterifying trimellitic acid with octyl alcohol to produce a plasticizer (trioctyl trimellitate: TOTM).
- trimellitic acid can be produced advantageously in terms of cost, and is an excellent production method from the viewpoint of environmental problems.
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Abstract
Description
本発明の目的は、ジメチルベンズアルデヒドおよび/またはその酸化誘導体を原料として高品質の高純度トリメリット酸を工業的に製造する方法を提供することにある。
1.ジメチルベンズアルデヒドおよび/またはその酸化誘導体を、触媒を含有する水溶媒中で分子状酸素により液相酸化を行い、トリメリット酸を製造する方法において、原料として3,4-ジメチルベンズアルデヒドおよび/または3,4-ジメチル安息香酸を使用し、触媒として水溶媒100質量部に対して、コバルト、マンガンおよびニッケルからなる群から選ばれる1種以上の金属0.05~1質量部、金属鉄および/または水溶性鉄塩より得られる鉄0.0001~0.0015質量部、臭素1~5質量部を含有する触媒を用い、200~250℃の温度で液相酸化することを特徴とする高純度トリメリット酸の製造法。
2.液相酸化を二段連続方式で行い、第二段階において全臭素供給量の5~50質量%を供給する上記1の高純度トリメリット酸の製造法。
3.水溶媒の質量が3,4-ジメチルベンズアルデヒドおよび/または3,4-ジメチル安息香酸の供給量に対して1~4倍である上記1又は2の高純度トリメリット酸の製造法。
また、触媒として使用した臭素の残存率が高いので、触媒を循環・再使用する場合の臭素補充量が少なくなり、製造コストが削減される。
さらに、これにより精製工程において排出される有機臭素化合物などの副生成物の排出量が少なくなるので、排水処理負荷が低下する。
従って、本発明の方法によれば、高純度のトリメリット酸を工業的に有利に製造することができる。
液相酸化によるトリメリット酸製造の原料であるジメチルベンズアルデヒドおよびその酸化反応誘導体としては、2,4-ジメチルベンズアルデヒド、2,5-ジメチルベンズアルデヒド、3,4-ジメチルベンズアルデヒド、2,4-ジメチル安息香酸、2,5-ジメチル安息香酸、3,4-ジメチル安息香酸と多く種類があり、従来は主に2,4-ジメチルベンズアルデヒドが使用されていた。本発明の製造法では、特に原料として3,4-ジメチルベンズアルデヒドおよび/または3,4-ジメチル安息香酸を用いるものである。
また、本発明の製造法では、空気を酸化剤、水を溶媒として、トリメリット酸を製造する方法で、従来の触媒に鉄を添加した触媒を使用するものであり、連続方式で製造することができる。
原料の3,4-ジメチルベンズアルデヒドおよび3,4-ジメチル安息香酸は単独でも混合物でも使用できる。
これらの金属を含む化合物を各々単独でも混合物でも使用できる。また、これらの金属を含む化合物はどの様な形態で使用しても構わず、有機塩、無機塩でも構わないが、水溶媒中にイオンとして存在することが望ましく、より好ましくは臭化物塩、具体的には、臭化コバルト、臭化マンガン、臭化ニッケルである。
触媒に用いる臭素としては臭化物イオンを発生する無機の臭素化合物が好ましく、前記のような金属臭化物塩を使用することができるが、臭化水素酸を用いることがより好ましい。
鉄含有量は水溶媒100質量部に対して0.0001~0.0015質量部であり、好ましくは0.0002~0.0010質量部である。
反応圧力は反応液を液相に保ち得る範囲であれば特に制約はないが、通常は1.6~6MPaの範囲である。多段連続方式における各段階の反応圧力は該圧力範囲内で選択することができる。
ここで言う臭化物イオン残存率とは、触媒として供した臭素(形態としては臭化物イオン)が反応副生成物である有機臭素化合物になることなく水溶媒中に臭化物イオンの形態で残存する割合である。臭化物イオンは触媒であると同時に反応物質ともなり、反応に供した臭化物イオンはある割合で有機臭素化合物に、残りが酸化活性のある触媒として水溶媒中に残存する。水溶媒中に残存する臭化物イオンの割合が高い場合、その水溶媒を反応にリサイクルすると残存する臭化物イオンが触媒として機能するため、新たに加えなければならない臭化物イオンの量が少なくてよい。つまり、反応後の水溶媒中に残存する臭化物イオンの割合が高いこと、即ち臭化物イオン残存率が高いことは触媒として利用される臭素の割合が高いと言える。
以下の実施例および比較例において、反応生成物を以下の条件にてガスクロマトグラフィー装置(GC装置)を用いて分析を行った。
機種:Agilent 6890N(Agilent Technologies社製)
使用カラム:DB-1(Agilent Technologies社製)
分析条件:Injection Temp 300℃
Detector Temp 300℃
カラム温度:100℃、3分保持→5℃/分で280℃まで昇温→280℃、 35分保持
検出器:水素炎イオン化検出器(FID)
分析方法:耐熱ガラス試験管に反応液1gを精評・採取し、メタノール3gを加えて希釈し、更に塩酸トリエチルアミン3gとリン酸トリメチル10mlを加える。その混合液を180℃で、40分間加熱することによりメチルエステル化処理する。処理液を冷却して室温とした後、その液にクロロホルム20mlを加え、更にGC分析の内部標準物質であるトリフェニルメタン0.1gを精評して加えて均一に溶解させる。このクロロホルム溶液に水200mlを加えて液-液分配処理を2回行い、静置して得られたクロロホルム層をGC装置で分析する。
臭化物イオンの濃度は以下の条件で測定した。
滴定装置:電位差自動滴定装置 AT-510(京都電子工業株式会社製)
滴定液:1/250規定硝酸銀水溶液
検出電極:複合ガラス電極 C-172
銀電極 M-214
温度補償電極 T-111
測定方法:200mlビーカーにテフロン(登録商標)製攪拌子を入れ、サンプルを適量入れる(天秤にてサンプル質量を精評する)。純水を加えてビーカー内の液量を約150mlとし、更に60質量%の硝酸を約2ml加える。上記自動滴定装置にて沈殿滴定を行い、臭化物イオン濃度を求める。
還流冷却器、攪拌装置、加熱装置および原料導入口、ガス導入口、反応物排出口を供えた内容積2Lのジルコニウム製酸化反応器2台を接続した連続2段式反応器を用いて3,4-ジメチルベンズアルデヒド(3,4-DBAL)の液相空気酸化を行った。ポリッシャー付純水製造装置で得られた水1422質量部、臭化水素酸水溶液(試薬:和光純薬工業株式会社製、HBr47.0~49.0質量%)37.3質量部、MnBr2・4H2O(試薬:三津和薬品株式会社製)30.5質量部および50質量%FeBr3水溶液(試薬:三津和薬品株式会社製、Fe含有量として9.4質量%)0.08質量部をこの比率で混合し、触媒液Aを調製した。また、水55.7質量部および臭化水素酸水溶液(試薬:和光純薬工業株式会社製、HBr47.0~49.0質量%)4.3質量部をこの比率で混合し、触媒液Bを調製した。
この間、反応器の圧力は1段目が3.2MPa、2段目が2.9MPaに保った。水溶媒の量は3,4-ジメチルベンズアルデヒドに対し質量比で3.94倍であり、各触媒成分の量は、それぞれ水100質量部に対して、臭素が合計で2.3質量部、マンガンが0.39質量部、鉄が0.0005質量部(5ppm)であった。また、2段目反応器への臭素供給量は臭素全供給量の10.5質量%であった。
鉄含有量を水100質量部に対して0.0002(2ppm)質量部となるように触媒液組成を調製した以外は実施例1と同様に反応を行い、反応生成物をGC分析した。その結果、トリメリット酸は89%、トリメリット酸臭素化物は0.1%、ジカルボキシメチルベンゼンは0.4%、トリメライドは1.4%、フタル酸は0.0%、ピロメリット酸は0.2%の収率で得られた。また臭化物イオン残存率は83%であった。結果を第1表に示す。
鉄含有量を水100質量部に対して0.001質量部(10ppm)となるように触媒液組成を調製した以外は実施例1と同様に反応を行い、反応生成物をGC分析した。その結果、トリメリット酸は92%、トリメリット酸臭素化物は0.1%、ジカルボキシメチルベンゼンは1.1%、トリメライドは2.0%、フタル酸は0.1%、ピロメリット酸は0.1%の収率で得られた。また臭化物イオン残存率は84%であった。結果を第1表に示す。
各反応器の温度を210℃とした以外は実施例1と同様に反応を行い、反応生成物をGC分析した。その結果、トリメリット酸は89%、トリメリット酸臭素化物は0.1%、ジカルボキシメチルベンゼンは1.2%、トリメライドは3.1%、フタル酸は0.0%、ピロメリット酸は0.1%の収率で得られた。また臭化物イオン残存率は82%であった。結果を第1表に示す。
臭素量を合計で1.5質量部(2段目反応器へは10.5質量%)とした以外は実施例1と同様に反応行い、反応生成物をGC分析した。その結果、トリメリット酸は91%、トリメリット酸臭素化物は0.1%、ジカルボキシメチルベンゼンは0.9%、トリメライドは1.8%、フタル酸は0.0%、ピロメリット酸は0.2%の収率で得られた。また臭化物イオン残存率は79%であった。結果を第1表に示す。
原料の3,4-ジメチルベンズアルデヒドに代えて3,4-ジメチル安息香酸(3,4-DBA)を使用した以外は実施例1と同様に反応行い、反応生成物をGC分析した。その結果、トリメリット酸は93%、トリメリット酸臭素化物は0.1%、ジカルボキシメチルベンゼンは0.4%、トリメライドは1.5%、フタル酸は0.0%、ピロメリット酸は0.1%の収率で得られた。また臭化物イオン残存率は86%であった。結果を第1表に示す。
50質量%FeBr3水溶液を使用しなかった以外は実施例4と同様に反応を行い、反応生成物をGC分析した。その結果、トリメリット酸は66%、トリメリット酸臭素化物は0.2%、ジカルボキシメチルベンゼンは0.8%、トリメライドは4.4%、フタル酸は0.1%、ピロメリット酸は0.1%の収率で得られた。また臭化物イオン残存率は74%であった。結果を第2表に示す。
鉄含有量を水100質量部に対して0.0020質量部(20ppm)となるように触媒液組成を調製した以外は実施例4と同様に反応を行い、反応生成物をGC分析した。その結果、トリメリット酸は86%、トリメリット酸臭素化物は0.1%、ジカルボキシメチルベンゼンは1.4%、トリメライドは3.9%、フタル酸は0.1%、ピロメリット酸は0.4%の収率で得られた。また臭化物イオン残存率は76%であった。結果を第2表に示す。
酸化原料を2,4-ジメチルベンズアルデヒド(2,4-DBAL)とした以外は実施例1と同様に反応を行い、反応生成物をGC分析した。その結果、トリメリット酸は87%、トリメリット酸臭素化物は0.9%、ジカルボキシメチルベンゼンは0.3%、トリメライドは1.2%、フタル酸は0.0%、ピロメリット酸は0.1%の収率で得られた。また臭化物イオン残存率は39%であった。結果を第2表に示す。
酸化原料を2,4-ジメチルベンズアルデヒドとした以外は実施例3と同様に反応を行い、反応生成物をGC分析した。その結果、トリメリット酸は83%、トリメリット酸臭素化物は0.9%、ジカルボキシメチルベンゼンは0.7%、トリメライドは2.0%、フタル酸は0.0%、ピロメリット酸は0.2%の収率で得られた。また臭化物イオン残存率は34%であった。結果を第2表に示す。
50質量%FeBr3水溶液を使用しなかった以外は比較例3と同様に液相空気酸化を行った。その結果、トリメリット酸は91%、トリメリット酸臭素化物は0.8%、ジカルボキシメチルベンゼンは0.4%、トリメライドは2.1%、フタル酸は0.1%、ピロメリット酸は0.1%の収率で得られた。また臭化物イオン残存率は56%であった。結果を第2表に示す。
触媒成分濃度は水溶媒100質量部当りの触媒成分質量、トリメリット酸などの収率は上記原料に対して得られたトリメリット酸などのモル比(%)であり、臭化物イオン残存率は、前記のように、触媒成分として供給した臭素(臭化物イオン)に対する反応生成液中の臭化物イオンのモル比(%)である。
トリメライドの一つである1-カルボキシ-3,4-フタリドは下記右の化学構造式で示される化合物である。
(1)実施例1~5および比較例1から、本発明のように3,4-ジメチルベンズアルデヒドを原料にし、水溶媒中、連続式で液相空気酸化する際に、触媒に鉄を添加しないとトリメリット酸の収率が70%に満たず、満足な収率を得ることが出来ない。しかし鉄を2ppm,5ppm,10ppm添加した場合には90%程度と工業的に充分な収率でトリメリット酸を得ることができる。
Claims (3)
- ジメチルベンズアルデヒドおよび/またはその酸化誘導体を、触媒を含有する水溶媒中で分子状酸素により液相酸化を行い、トリメリット酸を製造する方法において、原料として3,4-ジメチルベンズアルデヒドおよび/または3,4-ジメチル安息香酸を使用し、触媒として水溶媒100質量部に対して、コバルト、マンガンおよびニッケルからなる群から選ばれる1種以上の金属0.05~1質量部、金属鉄および/または水溶性鉄塩より得られる鉄0.0001~0.0015質量部、臭素1~5質量部を含有する触媒を用い、200~250℃の温度で液相酸化することを特徴とする高純度トリメリット酸の製造法。
- 液相酸化を二段連続方式で行い、第二段階において全臭素供給量の5~50質量%を供給する請求項1に記載の高純度トリメリット酸の製造法。
- 水溶媒の質量が3,4-ジメチルベンズアルデヒドおよび/または3,4-ジメチル安息香酸の供給量に対して1~4倍である請求項1又は2に記載の高純度トリメリット酸の製造法。
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EP09735832.9A EP2269973A4 (en) | 2008-04-22 | 2009-04-07 | METHOD FOR MANUFACTURING HIGH-PURITY TRIMELLITIC ACID |
US12/988,543 US20110112323A1 (en) | 2008-04-22 | 2009-04-07 | Process for production of high-purity trimellitic acid |
CN200980111234.0A CN101980997B (zh) | 2008-04-22 | 2009-04-07 | 一种高纯度偏苯三酸的制备方法 |
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CN109164199A (zh) * | 2018-09-13 | 2019-01-08 | 淄博润源化工有限公司 | 3,4-二甲基苯甲醛含量及杂质测定方法 |
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JPS5626839A (en) | 1979-08-13 | 1981-03-16 | Mitsubishi Gas Chem Co Inc | Preparation of aromatic polycarboxylic acid |
JPS5738745A (en) * | 1980-08-18 | 1982-03-03 | Mitsubishi Gas Chem Co Inc | Preparation of trimellitic acid or pyromellitic acid |
JPS63130556A (ja) * | 1986-11-20 | 1988-06-02 | Mitsubishi Gas Chem Co Inc | ピロメリツト酸の製造方法 |
JPH1192416A (ja) * | 1997-09-19 | 1999-04-06 | Mitsubishi Gas Chem Co Inc | トリメリット酸の製造法 |
JPH11335317A (ja) * | 1998-05-27 | 1999-12-07 | Mitsubishi Gas Chem Co Inc | トリメリット酸の製造法 |
JP2002003440A (ja) | 2000-06-27 | 2002-01-09 | Mitsubishi Gas Chem Co Inc | 芳香族ポリカルボン酸の製造法 |
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US3341470A (en) * | 1963-02-27 | 1967-09-12 | Standard Oil Co | Chemical process |
US5895820A (en) * | 1997-07-16 | 1999-04-20 | Mitsubishi Gas Chemical Company, Inc. | Process for the production of trimellitic acid and process for the production of trimellitic acid anhydride |
US6194607B1 (en) * | 1998-12-22 | 2001-02-27 | Samsung General Chemicals Co., Ltd. | Method of producing aromatic carboxylic acids by oxidizing alkyl aromatic hydrocarbons or partially oxidized intermediates thereof |
KR100549107B1 (ko) * | 1999-04-28 | 2006-02-06 | 삼성토탈 주식회사 | 아로마틱 폴리카본산의 제조방법 |
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- 2009-04-07 WO PCT/JP2009/057119 patent/WO2009130997A1/ja active Application Filing
- 2009-04-07 JP JP2010509132A patent/JP5402924B2/ja active Active
- 2009-04-07 KR KR1020107021945A patent/KR20110013359A/ko not_active Application Discontinuation
- 2009-04-07 US US12/988,543 patent/US20110112323A1/en not_active Abandoned
- 2009-04-07 CN CN200980111234.0A patent/CN101980997B/zh not_active Expired - Fee Related
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US3491144A (en) | 1966-09-20 | 1970-01-20 | Standard Oil Co | Production of aromatic tricarboxylic acids having only two vicinal carboxylic acid groups |
JPS5626839A (en) | 1979-08-13 | 1981-03-16 | Mitsubishi Gas Chem Co Inc | Preparation of aromatic polycarboxylic acid |
JPS5738745A (en) * | 1980-08-18 | 1982-03-03 | Mitsubishi Gas Chem Co Inc | Preparation of trimellitic acid or pyromellitic acid |
JPS63130556A (ja) * | 1986-11-20 | 1988-06-02 | Mitsubishi Gas Chem Co Inc | ピロメリツト酸の製造方法 |
JPH1192416A (ja) * | 1997-09-19 | 1999-04-06 | Mitsubishi Gas Chem Co Inc | トリメリット酸の製造法 |
JPH11335317A (ja) * | 1998-05-27 | 1999-12-07 | Mitsubishi Gas Chem Co Inc | トリメリット酸の製造法 |
JP2002003440A (ja) | 2000-06-27 | 2002-01-09 | Mitsubishi Gas Chem Co Inc | 芳香族ポリカルボン酸の製造法 |
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CN101980997B (zh) | 2013-08-21 |
KR20110102763A (ko) | 2011-09-19 |
EP2269973A4 (en) | 2013-08-14 |
US20110112323A1 (en) | 2011-05-12 |
JPWO2009130997A1 (ja) | 2011-08-18 |
EP2269973A1 (en) | 2011-01-05 |
JP5402924B2 (ja) | 2014-01-29 |
TW200951108A (en) | 2009-12-16 |
KR20110013359A (ko) | 2011-02-09 |
CN101980997A (zh) | 2011-02-23 |
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