WO2009113645A8 - 非荷電性親水性ブロック及び側鎖の一部に疎水性基が導入されカチオン性のポリアミノ酸ブロックを含んでなる共重合体、その使用 - Google Patents

非荷電性親水性ブロック及び側鎖の一部に疎水性基が導入されカチオン性のポリアミノ酸ブロックを含んでなる共重合体、その使用 Download PDF

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Publication number
WO2009113645A8
WO2009113645A8 PCT/JP2009/054824 JP2009054824W WO2009113645A8 WO 2009113645 A8 WO2009113645 A8 WO 2009113645A8 JP 2009054824 W JP2009054824 W JP 2009054824W WO 2009113645 A8 WO2009113645 A8 WO 2009113645A8
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WO
WIPO (PCT)
Prior art keywords
copolymer
polyamino acid
block
chain block
hydrophobic radical
Prior art date
Application number
PCT/JP2009/054824
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English (en)
French (fr)
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WO2009113645A1 (ja
Inventor
片岡　一則
西山　伸宏
篤史 石井
加藤　泰己
完ニ郎 宮田
ヒョンジン キム
宏泰 武元
Original Assignee
国立大学法人 東京大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 国立大学法人 東京大学 filed Critical 国立大学法人 東京大学
Priority to AU2009224286A priority Critical patent/AU2009224286B2/en
Priority to JP2010502885A priority patent/JP5467366B2/ja
Priority to EP09720268.3A priority patent/EP2272897B1/en
Priority to CN2009801084707A priority patent/CN101970541B/zh
Priority to US12/922,116 priority patent/US8431545B2/en
Priority to CA2718003A priority patent/CA2718003C/en
Publication of WO2009113645A1 publication Critical patent/WO2009113645A1/ja
Publication of WO2009113645A8 publication Critical patent/WO2009113645A8/ja

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

本発明は、非荷電性親水性ポリマー鎖ブロック及びカチオン性ポリアミノ酸鎖ブロックを含んでなるブロック共重合体を開示する。該共重合体は、親水性ポリマー鎖ブロックが該ポリアミノ酸鎖ブロックの主鎖のいずれか一方の末端に共有結合を介して結合しており、かつ、該ポリアミノ酸鎖ブロックにおけるアミノ酸反復単位１０パーセント以上から７０パーセント以下の側鎖に疎水性基が共有結合を介して結合している。該共重合体は小分子核酸であるｓｉＲＮＡとも生理的条件下で安定な会合体を提供する。
PCT/JP2009/054824 2008-03-10 2009-03-06 非荷電性親水性ブロック及び側鎖の一部に疎水性基が導入されカチオン性のポリアミノ酸ブロックを含んでなる共重合体、その使用 WO2009113645A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2009224286A AU2009224286B2 (en) 2008-03-10 2009-03-06 Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof
JP2010502885A JP5467366B2 (ja) 2008-03-10 2009-03-06 非荷電性親水性ブロック及び側鎖の一部に疎水性基が導入されたカチオン性のポリアミノ酸ブロックを含んでなる共重合体、その使用
EP09720268.3A EP2272897B1 (en) 2008-03-10 2009-03-06 Copolymer including uncharged hydrophilic block and cationic polyamino acid block having lateral chain to which hydrophobic radical is partially introduced, and use of copolymer
CN2009801084707A CN101970541B (zh) 2008-03-10 2009-03-06 包含非荷电性亲水性嵌段以及侧链的一部分引入了疏水性基团的阳离子性聚氨基酸嵌段的共聚物、及其使用
US12/922,116 US8431545B2 (en) 2008-03-10 2009-03-06 Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof
CA2718003A CA2718003C (en) 2008-03-10 2009-03-06 Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008-059886 2008-03-10
JP2008059886 2008-03-10

Publications (2)

Publication Number Publication Date
WO2009113645A1 WO2009113645A1 (ja) 2009-09-17
WO2009113645A8 true WO2009113645A8 (ja) 2010-11-18

Family

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PCT/JP2009/054824 WO2009113645A1 (ja) 2008-03-10 2009-03-06 非荷電性親水性ブロック及び側鎖の一部に疎水性基が導入されカチオン性のポリアミノ酸ブロックを含んでなる共重合体、その使用

Country Status (9)

Country Link
US (1) US8431545B2 (ja)
EP (1) EP2272897B1 (ja)
JP (1) JP5467366B2 (ja)
KR (1) KR101564796B1 (ja)
CN (1) CN101970541B (ja)
AU (1) AU2009224286B2 (ja)
CA (1) CA2718003C (ja)
TW (1) TWI459968B (ja)
WO (1) WO2009113645A1 (ja)

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Also Published As

Publication number Publication date
EP2272897A1 (en) 2011-01-12
CA2718003C (en) 2016-05-03
CA2718003A1 (en) 2009-09-17
KR20100138910A (ko) 2010-12-31
CN101970541B (zh) 2013-12-04
AU2009224286A1 (en) 2009-09-17
WO2009113645A1 (ja) 2009-09-17
JPWO2009113645A1 (ja) 2011-07-21
TW200948384A (en) 2009-12-01
US20110052917A1 (en) 2011-03-03
EP2272897B1 (en) 2016-12-28
KR101564796B1 (ko) 2015-10-30
EP2272897A4 (en) 2012-01-25
JP5467366B2 (ja) 2014-04-09
US8431545B2 (en) 2013-04-30
CN101970541A (zh) 2011-02-09
AU2009224286B2 (en) 2014-06-12
TWI459968B (zh) 2014-11-11

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