WO2009100587A1 - Composition de médicament pour le traitement et la prévention d'un accident ischémique cérébral et ses procédés de préparation - Google Patents

Composition de médicament pour le traitement et la prévention d'un accident ischémique cérébral et ses procédés de préparation Download PDF

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Publication number
WO2009100587A1
WO2009100587A1 PCT/CN2008/000349 CN2008000349W WO2009100587A1 WO 2009100587 A1 WO2009100587 A1 WO 2009100587A1 CN 2008000349 W CN2008000349 W CN 2008000349W WO 2009100587 A1 WO2009100587 A1 WO 2009100587A1
Authority
WO
WIPO (PCT)
Prior art keywords
separation
extraction
kettle
oil
product
Prior art date
Application number
PCT/CN2008/000349
Other languages
English (en)
Chinese (zh)
Inventor
Huiwan Han
Liang JI
Yanda Li
Mingyu Ding
Original Assignee
Tsinghua University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsinghua University filed Critical Tsinghua University
Priority to CN2008800014789A priority Critical patent/CN101677989B/zh
Priority to PCT/CN2008/000349 priority patent/WO2009100587A1/fr
Publication of WO2009100587A1 publication Critical patent/WO2009100587A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8988—Gastrodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Abstract

L'invention porte sur une composition de médicament pour le traitement et la prévention d'un accident ischémique cérébral et sur ses procédés de préparation. La composition de médicament consiste en 19-72 % de Sédanolide, 17-67 % de Ligustilide, 2-29 % de Gastrodine et un solvant. Elle a une pureté élevée de plus de 98 %. La composition de médicament peut être préparée sous différentes formes de médicaments, comprenant une injection, et elle peut soulager de manière efficace les symptômes de la maladie.
PCT/CN2008/000349 2008-02-14 2008-02-14 Composition de médicament pour le traitement et la prévention d'un accident ischémique cérébral et ses procédés de préparation WO2009100587A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN2008800014789A CN101677989B (zh) 2008-02-14 2008-02-14 一种防治缺血性脑卒中的药物组合物及其制备方法
PCT/CN2008/000349 WO2009100587A1 (fr) 2008-02-14 2008-02-14 Composition de médicament pour le traitement et la prévention d'un accident ischémique cérébral et ses procédés de préparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2008/000349 WO2009100587A1 (fr) 2008-02-14 2008-02-14 Composition de médicament pour le traitement et la prévention d'un accident ischémique cérébral et ses procédés de préparation

Publications (1)

Publication Number Publication Date
WO2009100587A1 true WO2009100587A1 (fr) 2009-08-20

Family

ID=40956622

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2008/000349 WO2009100587A1 (fr) 2008-02-14 2008-02-14 Composition de médicament pour le traitement et la prévention d'un accident ischémique cérébral et ses procédés de préparation

Country Status (2)

Country Link
CN (1) CN101677989B (fr)
WO (1) WO2009100587A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102626390A (zh) * 2012-04-19 2012-08-08 海南灵康制药有限公司 一种天麻素多相脂质体注射液
CN102688184A (zh) * 2012-05-15 2012-09-26 清华大学 改善大鼠血液流变障碍用的含有麻黄碱注射液的制备方法
CN102698089A (zh) * 2012-05-15 2012-10-03 清华大学 防治脑缺血用的含有麻黄碱提取物的口服液的制备方法
CN104415044A (zh) * 2013-08-30 2015-03-18 陈震 一种治疗中风及其后遗症的药物组合物及其制剂

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102688253A (zh) * 2012-05-15 2012-09-26 清华大学 改善脑缺血用的含有麻黄碱的注射液的制备方法

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WO2004017983A1 (fr) * 2002-08-20 2004-03-04 National University Of Singapore Procede de preparation d'extraits phytoprogestogeniques du rhizome de ligusticum chuanxiong et leurs utilisations
CN1559417A (zh) * 2004-03-05 2005-01-05 嵩 张 天麻素静脉注射液及其制备方法
CN1569848A (zh) * 2003-07-14 2005-01-26 中国中医研究院中药研究所 治疗缺血性心脏病的川芎内酯及其制备方法
CN1572310A (zh) * 2003-06-11 2005-02-02 山东绿叶天然药物研究开发有限公司 一种川芎挥发油软胶囊及其制备方法
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CN1883661A (zh) * 2006-05-31 2006-12-27 本溪市中心医院 大川芎干粉制剂及制备方法和用途
WO2007038610A2 (fr) * 2005-09-26 2007-04-05 President & Fellows Of Harvard College Utilisation de produits naturels pour le traitement de troubles neurologiques
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CN1572310A (zh) * 2003-06-11 2005-02-02 山东绿叶天然药物研究开发有限公司 一种川芎挥发油软胶囊及其制备方法
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CN1559417A (zh) * 2004-03-05 2005-01-05 嵩 张 天麻素静脉注射液及其制备方法
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CN1883661A (zh) * 2006-05-31 2006-12-27 本溪市中心医院 大川芎干粉制剂及制备方法和用途
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102626390A (zh) * 2012-04-19 2012-08-08 海南灵康制药有限公司 一种天麻素多相脂质体注射液
CN102626390B (zh) * 2012-04-19 2013-05-29 海南灵康制药有限公司 一种天麻素多相脂质体注射液
CN102688184A (zh) * 2012-05-15 2012-09-26 清华大学 改善大鼠血液流变障碍用的含有麻黄碱注射液的制备方法
CN102698089A (zh) * 2012-05-15 2012-10-03 清华大学 防治脑缺血用的含有麻黄碱提取物的口服液的制备方法
CN104415044A (zh) * 2013-08-30 2015-03-18 陈震 一种治疗中风及其后遗症的药物组合物及其制剂
CN104415044B (zh) * 2013-08-30 2018-10-16 陈震 一种治疗中风及其后遗症的药物组合物及其制剂

Also Published As

Publication number Publication date
CN101677989A (zh) 2010-03-24
CN101677989B (zh) 2012-10-10

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