WO2009063897A1 - 皮膚の乾癬予防または改善剤 - Google Patents

皮膚の乾癬予防または改善剤 Download PDF

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Publication number
WO2009063897A1
WO2009063897A1 PCT/JP2008/070578 JP2008070578W WO2009063897A1 WO 2009063897 A1 WO2009063897 A1 WO 2009063897A1 JP 2008070578 W JP2008070578 W JP 2008070578W WO 2009063897 A1 WO2009063897 A1 WO 2009063897A1
Authority
WO
WIPO (PCT)
Prior art keywords
psoriasis
skin
prophylactic
ameliorating agent
ameliorating
Prior art date
Application number
PCT/JP2008/070578
Other languages
English (en)
French (fr)
Inventor
Ayako Kamimura
Toshikazu Kamiya
Masahiko Nakano
Kazutoshi Kikkawa
Original Assignee
Kyowa Hakko Bio Co., Ltd.
Mitsubishi Gas Chemical Company, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co., Ltd., Mitsubishi Gas Chemical Company, Inc. filed Critical Kyowa Hakko Bio Co., Ltd.
Priority to JP2009541149A priority Critical patent/JP5392089B2/ja
Priority to CA2705372A priority patent/CA2705372A1/en
Priority to US12/742,351 priority patent/US8575190B2/en
Publication of WO2009063897A1 publication Critical patent/WO2009063897A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Abstract

　本発明の目的は、安全で効果の高い皮膚の乾癬予防または改善剤を提供することにある。 　本発明によれば、一般式（Ｉ） （式中、Ｒ１、Ｒ２およびＲ３は同一または異なって、低級アルキル、低級アルケニル、低級アルキニル、アラルキル、アラアリール、フェニル、水素原子を表す。）で表される化合物、またはその塩を有効成分として含有する皮膚の乾癬予防または改善剤を提供することができる。
PCT/JP2008/070578 2007-11-14 2008-11-12 皮膚の乾癬予防または改善剤 WO2009063897A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009541149A JP5392089B2 (ja) 2007-11-14 2008-11-12 皮膚の乾癬予防または改善剤
CA2705372A CA2705372A1 (en) 2007-11-14 2008-11-12 Preventing or ameliorating agent for skin psoriasis
US12/742,351 US8575190B2 (en) 2007-11-14 2008-11-12 Method of preventing or ameliorating psoriasis using pyrroloquinoline quinone compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007296022 2007-11-14
JP2007-296022 2007-11-14

Publications (1)

Publication Number Publication Date
WO2009063897A1 true WO2009063897A1 (ja) 2009-05-22

Family

ID=40638746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/070578 WO2009063897A1 (ja) 2007-11-14 2008-11-12 皮膚の乾癬予防または改善剤

Country Status (4)

Country Link
US (1) US8575190B2 (ja)
JP (1) JP5392089B2 (ja)
CA (1) CA2705372A1 (ja)
WO (1) WO2009063897A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103119044A (zh) * 2010-09-22 2013-05-22 三菱瓦斯化学株式会社 吡咯并喹啉醌的钙盐
JP2016185151A (ja) * 2010-06-15 2016-10-27 セルジーン コーポレイション 乾癬の治療のためのバイオマーカー
JP2019503401A (ja) * 2016-02-04 2019-02-07 南京舒鵬生物科技有限公司Ｎａｎｊｉｎｇ Ｓｈｕｐｅｎｇ Ｌｉｆｅｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ ピロロキノリンキノン、その誘導体及び／又は塩の乾燥症候群における使用ならびに医薬組成物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946423B2 (en) * 2010-11-26 2015-02-03 Mitsubishi Gas Chemical Company, Inc. Highly soluble salt of pyrroloquinoline quinone and method for producing the same
AU2012268427B2 (en) * 2011-06-06 2016-02-04 Dermaforce Holdings, LLC Skin treatments containing pyrroloquinoline quinone (PQQ) esters and methods of preparation and use thereof
US9394298B2 (en) * 2012-08-17 2016-07-19 Mitsubishi Gas Chemical Company, Inc. Pyrroloquinoline quinone tetraalkali salt and crystal thereof, methods for producing these, and composition
JP6825330B2 (ja) * 2016-11-25 2021-02-03 三菱瓦斯化学株式会社 オートファジー誘導剤

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02268118A (ja) * 1989-04-07 1990-11-01 Mitsubishi Gas Chem Co Inc 免疫賦活剤
JPH03112912A (ja) * 1989-09-27 1991-05-14 Sanko Seibutsu Kagaku Kenkyusho:Kk 化粧料組成物
JPH0578247A (ja) * 1991-03-04 1993-03-30 Mitsubishi Gas Chem Co Inc 活性酸素消去剤
JPH0820585A (ja) * 1994-07-07 1996-01-23 Mitsubishi Gas Chem Co Inc 紫外線吸収剤及び皮膚外用剤
JPH0820512A (ja) * 1994-07-07 1996-01-23 Mitsubishi Gas Chem Co Inc メラニン産生抑制剤及び美白用皮膚外用剤
JP2004512260A (ja) * 2000-04-28 2004-04-22 メモリアル　スローン−ケッタリング　キャンサー　センター 局所麻酔／オピオイド製剤およびその使用方法

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Publication number Priority date Publication date Assignee Title
US5369112A (en) * 1991-03-04 1994-11-29 Mitsubishi Gas Chemical Company, Inc. Method of treating cataracts caused by active oxygen
US20030105031A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Methods for the treatment of skin disorders
CN101553488A (zh) * 2006-09-08 2009-10-07 协和发酵生化株式会社 高血压改善剂
US8097635B2 (en) * 2006-09-19 2012-01-17 Kyowa Hakko Bio Co., Ltd. Insulin resistance improving agent

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02268118A (ja) * 1989-04-07 1990-11-01 Mitsubishi Gas Chem Co Inc 免疫賦活剤
JPH03112912A (ja) * 1989-09-27 1991-05-14 Sanko Seibutsu Kagaku Kenkyusho:Kk 化粧料組成物
JPH0578247A (ja) * 1991-03-04 1993-03-30 Mitsubishi Gas Chem Co Inc 活性酸素消去剤
JPH0820585A (ja) * 1994-07-07 1996-01-23 Mitsubishi Gas Chem Co Inc 紫外線吸収剤及び皮膚外用剤
JPH0820512A (ja) * 1994-07-07 1996-01-23 Mitsubishi Gas Chem Co Inc メラニン産生抑制剤及び美白用皮膚外用剤
JP2004512260A (ja) * 2000-04-28 2004-04-22 メモリアル　スローン−ケッタリング　キャンサー　センター 局所麻酔／オピオイド製剤およびその使用方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KOZO NAKAI: "Hifu to Kassei Sanso", HIFUKA NO RINSHO, vol. 49, no. 7, 1 July 2007 (2007-07-01), pages 767 - 775 *
NAITO, Y. ET AL.: "EFFECTS OF PYRROLOQUINOLINE QUINONE (PQQ) AND PQQ-OXAZOLE ON DNA SYNTHESIS OF CULTURED HUMAN FIBROBLASTS", LIFE SCIENCES, vol. 52, no. 24, 1993, pages 1909 - 1915 *
YOSHIKI MIYAJI: "Free Radical to Hifu Shikkan", PHARMA MEDICA, vol. 8, no. 4, 1990, pages 67 - 71 *
YOSHIKI MIYAJI: "Sanka Stress to Hifu Shikkan- Hifu mo Sabiru", SHUKAN IGAKU NO AYUMI, 5 October 2006 (2006-10-05), pages 330 - 333 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016185151A (ja) * 2010-06-15 2016-10-27 セルジーン コーポレイション 乾癬の治療のためのバイオマーカー
CN103119044A (zh) * 2010-09-22 2013-05-22 三菱瓦斯化学株式会社 吡咯并喹啉醌的钙盐
CN103119044B (zh) * 2010-09-22 2017-02-08 三菱瓦斯化学株式会社 吡咯并喹啉醌的钙盐
JP2019503401A (ja) * 2016-02-04 2019-02-07 南京舒鵬生物科技有限公司Ｎａｎｊｉｎｇ Ｓｈｕｐｅｎｇ Ｌｉｆｅｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ ピロロキノリンキノン、その誘導体及び／又は塩の乾燥症候群における使用ならびに医薬組成物

Also Published As

Publication number Publication date
US8575190B2 (en) 2013-11-05
JPWO2009063897A1 (ja) 2011-03-31
JP5392089B2 (ja) 2014-01-22
CA2705372A1 (en) 2009-05-22
US20100261749A1 (en) 2010-10-14

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