WO2009048148A1 - シトルリンおよびアルギニンを含有する即効性血中アルギニン濃度上昇型経口剤 - Google Patents

シトルリンおよびアルギニンを含有する即効性血中アルギニン濃度上昇型経口剤 Download PDF

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Publication number
WO2009048148A1
WO2009048148A1 PCT/JP2008/068505 JP2008068505W WO2009048148A1 WO 2009048148 A1 WO2009048148 A1 WO 2009048148A1 JP 2008068505 W JP2008068505 W JP 2008068505W WO 2009048148 A1 WO2009048148 A1 WO 2009048148A1
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Prior art keywords
arginine
blood
level
increasable
acting
Prior art date
Application number
PCT/JP2008/068505
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English (en)
French (fr)
Inventor
Masayuki Ochiai
Koji Morishita
Toshio Hayashi
Original Assignee
Kyowa Hakko Bio Co., Ltd.
National University Corporation Nagoya University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co., Ltd., National University Corporation Nagoya University filed Critical Kyowa Hakko Bio Co., Ltd.
Priority to CN200880111265A priority Critical patent/CN101820871A/zh
Priority to EP17204001.6A priority patent/EP3320895B1/en
Priority to CA2702045A priority patent/CA2702045C/en
Priority to EP08836945.9A priority patent/EP2210600B1/en
Priority to US12/682,483 priority patent/US8609735B2/en
Priority to JP2009537046A priority patent/JP5813919B2/ja
Publication of WO2009048148A1 publication Critical patent/WO2009048148A1/ja
Priority to US14/104,258 priority patent/US9060980B2/en
Priority to US14/743,549 priority patent/US9622998B2/en
Priority to US15/454,325 priority patent/US10052298B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

　本発明は、シトルリンまたはその塩およびアルギニンまたはその塩を有効成分として含有する、即効性血中アルギニン濃度上昇型経口剤を提供する。本発明に係る即効性血中アルギニン濃度上昇型経口剤は、摂取後血中のアルギニン濃度を迅速かつ効果的に高めることができ、速やかにアルギニンの摂取効果を得ることができる。
PCT/JP2008/068505 2007-10-10 2008-10-10 シトルリンおよびアルギニンを含有する即効性血中アルギニン濃度上昇型経口剤 WO2009048148A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CN200880111265A CN101820871A (zh) 2007-10-10 2008-10-10 可提高血液精氨酸水平的含有瓜氨酸和精氨酸的速效口服制剂
EP17204001.6A EP3320895B1 (en) 2007-10-10 2008-10-10 Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine
CA2702045A CA2702045C (en) 2007-10-10 2008-10-10 Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine
EP08836945.9A EP2210600B1 (en) 2007-10-10 2008-10-10 Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine
US12/682,483 US8609735B2 (en) 2007-10-10 2008-10-10 Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine
JP2009537046A JP5813919B2 (ja) 2007-10-10 2008-10-10 シトルリンおよびアルギニンを含有する即効性血中アルギニン濃度上昇型経口剤
US14/104,258 US9060980B2 (en) 2007-10-10 2013-12-12 Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine
US14/743,549 US9622998B2 (en) 2007-10-10 2015-06-18 Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine
US15/454,325 US10052298B2 (en) 2007-10-10 2017-03-09 Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007264090 2007-10-10
JP2007-264090 2007-10-10

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/682,483 A-371-Of-International US8609735B2 (en) 2007-10-10 2008-10-10 Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine
US14/104,258 Division US9060980B2 (en) 2007-10-10 2013-12-12 Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine

Publications (1)

Publication Number Publication Date
WO2009048148A1 true WO2009048148A1 (ja) 2009-04-16

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PCT/JP2008/068505 WO2009048148A1 (ja) 2007-10-10 2008-10-10 シトルリンおよびアルギニンを含有する即効性血中アルギニン濃度上昇型経口剤

Country Status (7)

Country Link
US (4) US8609735B2 (ja)
EP (2) EP3320895B1 (ja)
JP (4) JP5813919B2 (ja)
CN (2) CN101820871A (ja)
CA (2) CA2967587C (ja)
ES (1) ES2861583T3 (ja)
WO (1) WO2009048148A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013060406A (ja) * 2011-09-15 2013-04-04 Kyowa Hakko Bio Co Ltd 脳疲労改善用経口剤
JP2016121194A (ja) * 2016-04-05 2016-07-07 協和発酵バイオ株式会社 脳疲労改善用経口剤
WO2016167254A1 (ja) * 2015-04-17 2016-10-20 株式会社山田養蜂場本社 蜂の子を含有する滋養強壮剤
WO2018225167A1 (ja) * 2017-06-07 2018-12-13 花王株式会社 アンモニア代謝促進剤
WO2018225482A1 (ja) 2017-06-07 2018-12-13 花王株式会社 アンモニア代謝促進剤
WO2021193820A1 (ja) * 2020-03-26 2021-09-30 味の素株式会社 毛髪の太毛化促進用組成物、毛周期の成長期維持用組成物およびｖｅｇｆ産生促進用組成物、毛周期の休止期から成長期への移行促進用組成物およびｆｇｆ７産生促進用組成物、ならびに毛周期の正常化促進用組成物

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CZ2007695A3 (cs) 2005-04-11 2008-02-27 Savient Pharmaceuticals, Inc. Variantní formy urátoxidázy a jejich použití
US20120093950A1 (en) * 2010-10-19 2012-04-19 Klrm, Llc Compositions and methods for treating, inhibiting the onset, and slowing the progression of erectile dysfunction including naturally occuring age related erectile dysfunction
US9572848B1 (en) 2014-03-26 2017-02-21 Aemes Research L.L.L.P. Composition of matter for sexual dysfunction
KR101486534B1 (ko) 2014-10-27 2015-01-27 주식회사 한국팜비오 경구제제 및 경구제제 제조방법
KR102396603B1 (ko) 2015-09-16 2022-05-11 원광대학교산학협력단 시트룰린을 유효성분으로 함유하는 간 기능 개선용 조성물
FR3070010B1 (fr) * 2017-08-02 2020-12-25 Belles Feuilles Procede et systeme pour conditionner une composition d'extraits secs de plantes, et composition d'extraits secs de plantes ainsi mis en oeuvre.
KR102114370B1 (ko) * 2017-09-07 2020-05-26 주식회사 킴스헬스케어 에너지보급 및 근무력증 예방 및 개선용 경구투여용 시트룰린 말레이트 고형제제 조성물
US11571405B2 (en) * 2018-12-07 2023-02-07 Inxo A/S Compositions for improving sexual function
WO2022029614A1 (en) * 2020-08-04 2022-02-10 Gensan S.R.L. Composition comprising red beet extract
IT202100021728A1 (it) * 2021-08-11 2023-02-11 Andrea Salmaso Composizione amminoacidica come agente vasodilatatore
KR102633006B1 (ko) * 2023-04-21 2024-02-02 주식회사 아임뷰힐 천연 유래 성분을 포함하는 피로회복용 조성물

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013060406A (ja) * 2011-09-15 2013-04-04 Kyowa Hakko Bio Co Ltd 脳疲労改善用経口剤
WO2016167254A1 (ja) * 2015-04-17 2016-10-20 株式会社山田養蜂場本社 蜂の子を含有する滋養強壮剤
JPWO2016167254A1 (ja) * 2015-04-17 2018-01-11 株式会社山田養蜂場本社 蜂の子を含有する滋養強壮剤
JP2016121194A (ja) * 2016-04-05 2016-07-07 協和発酵バイオ株式会社 脳疲労改善用経口剤
WO2018225167A1 (ja) * 2017-06-07 2018-12-13 花王株式会社 アンモニア代謝促進剤
WO2018225482A1 (ja) 2017-06-07 2018-12-13 花王株式会社 アンモニア代謝促進剤
WO2018225618A1 (ja) 2017-06-07 2018-12-13 花王株式会社 アンモニア代謝促進剤
JPWO2018225618A1 (ja) * 2017-06-07 2020-04-09 花王株式会社 アンモニア代謝促進剤
US11291649B2 (en) 2017-06-07 2022-04-05 Kao Corporation Ammonia metabolism promoter
US11376234B2 (en) 2017-06-07 2022-07-05 Kao Corporation Ammonia metabolism promoter
JP7108610B2 (ja) 2017-06-07 2022-07-28 花王株式会社 アンモニア代謝促進剤
WO2021193820A1 (ja) * 2020-03-26 2021-09-30 味の素株式会社 毛髪の太毛化促進用組成物、毛周期の成長期維持用組成物およびｖｅｇｆ産生促進用組成物、毛周期の休止期から成長期への移行促進用組成物およびｆｇｆ７産生促進用組成物、ならびに毛周期の正常化促進用組成物

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US10052298B2 (en) 2018-08-21
EP3320895A1 (en) 2018-05-16
JP2017081970A (ja) 2017-05-18
CN101820871A (zh) 2010-09-01
US9622998B2 (en) 2017-04-18
US9060980B2 (en) 2015-06-23
EP2210600B1 (en) 2017-11-29
CA2967587C (en) 2019-01-29
JP5813919B2 (ja) 2015-11-17
EP2210600A1 (en) 2010-07-28
EP3320895B1 (en) 2021-03-10
JP5872636B2 (ja) 2016-03-01
US20140100284A1 (en) 2014-04-10
US20150320713A1 (en) 2015-11-12
EP2210600A4 (en) 2013-09-18
US8609735B2 (en) 2013-12-17
JP2016121161A (ja) 2016-07-07
US20100292332A1 (en) 2010-11-18
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CA2967587A1 (en) 2009-04-16
CN104248632A (zh) 2014-12-31
US20170172962A1 (en) 2017-06-22
JPWO2009048148A1 (ja) 2011-02-24
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