WO2009044919A1 - 安定な炭酸水素イオン含有薬液 - Google Patents

安定な炭酸水素イオン含有薬液 Download PDF

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Publication number
WO2009044919A1
WO2009044919A1 PCT/JP2008/068192 JP2008068192W WO2009044919A1 WO 2009044919 A1 WO2009044919 A1 WO 2009044919A1 JP 2008068192 W JP2008068192 W JP 2008068192W WO 2009044919 A1 WO2009044919 A1 WO 2009044919A1
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WO
WIPO (PCT)
Prior art keywords
drug solution
containing drug
bicarbonate ion
relates
blood purification
Prior art date
Application number
PCT/JP2008/068192
Other languages
English (en)
French (fr)
Inventor
Shigeto Oda
Tomohito Sadahiro
Masataka Nakamura
Syuichi Tanaka
Shogo Tokuoka
Hiroya Otani
Original Assignee
National University Corporation Chiba University
Fuso Pharmaceutical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40526332&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009044919(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by National University Corporation Chiba University, Fuso Pharmaceutical Industries, Ltd. filed Critical National University Corporation Chiba University
Priority to EP08835962.5A priority Critical patent/EP2206504A4/en
Priority to US12/680,857 priority patent/US8771749B2/en
Priority to JP2009536137A priority patent/JP5329420B2/ja
Priority to CN200880119483XA priority patent/CN101888846B/zh
Priority to CA2701249A priority patent/CA2701249C/en
Priority to KR1020107009482A priority patent/KR101183965B1/ko
Priority to AU2008307966A priority patent/AU2008307966B2/en
Publication of WO2009044919A1 publication Critical patent/WO2009044919A1/ja
Priority to US14/272,026 priority patent/US9795636B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261—Flexible containers having several compartments

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicinal Preparation (AREA)

Abstract

　本発明は、安定な炭酸水素イオン含有薬液、特にリン酸イオンの存在により安定性を向上させた炭酸水素塩含有透析用薬液に関する。また、本発明は、当該薬液からなる急性血液浄化用薬液、特に用時混合型急性血液浄化用透析液および補充液に関する。なおまた、本発明は、混合後も長時間にわたり不溶性微粒子や沈澱の生成が抑制される、低カリウム血症および低リン血症を生じない用時混合型の急性血液浄化用透析液および補充液に関する。
PCT/JP2008/068192 2007-10-05 2008-10-06 安定な炭酸水素イオン含有薬液 WO2009044919A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP08835962.5A EP2206504A4 (en) 2007-10-05 2008-10-06 STABLE IONIC BICARBONATE MEDICINES SOLUTION
US12/680,857 US8771749B2 (en) 2007-10-05 2008-10-06 Stable bicarbonate ion-containing drug solution
JP2009536137A JP5329420B2 (ja) 2007-10-05 2008-10-06 安定な炭酸水素イオン含有薬液
CN200880119483XA CN101888846B (zh) 2007-10-05 2008-10-06 稳定的含碳酸氢根离子的药物溶液
CA2701249A CA2701249C (en) 2007-10-05 2008-10-06 Stable bicarbonate ion-containing drug solution
KR1020107009482A KR101183965B1 (ko) 2007-10-05 2008-10-06 안정한 탄산수소 이온 함유 약액
AU2008307966A AU2008307966B2 (en) 2007-10-05 2008-10-06 Stable bicarbonate ion-containing drug solution
US14/272,026 US9795636B2 (en) 2007-10-05 2014-05-07 Stable bicarbonate ion-containing drug solution

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007262551 2007-10-05
JP2007-262551 2007-10-05

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/680,857 A-371-Of-International US8771749B2 (en) 2007-10-05 2008-10-06 Stable bicarbonate ion-containing drug solution
US14/272,026 Continuation US9795636B2 (en) 2007-10-05 2014-05-07 Stable bicarbonate ion-containing drug solution

Publications (1)

Publication Number Publication Date
WO2009044919A1 true WO2009044919A1 (ja) 2009-04-09

Family

ID=40526332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068192 WO2009044919A1 (ja) 2007-10-05 2008-10-06 安定な炭酸水素イオン含有薬液

Country Status (8)

Country Link
US (2) US8771749B2 (ja)
EP (1) EP2206504A4 (ja)
JP (2) JP5329420B2 (ja)
KR (1) KR101183965B1 (ja)
CN (1) CN101888846B (ja)
AU (1) AU2008307966B2 (ja)
CA (1) CA2701249C (ja)
WO (1) WO2009044919A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013138827A (ja) * 2011-12-06 2013-07-18 Tomita Pharmaceutical Co Ltd 重炭酸透析剤
WO2017038099A1 (ja) * 2015-09-04 2017-03-09 ニプロ株式会社 標準液充填体およびその利用
JP7395288B2 (ja) 2019-08-30 2023-12-11 ポッカサッポロフード＆ビバレッジ株式会社 アンジオテンシンＩＩＴｙｐｅ１受容体拮抗剤

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US7736328B2 (en) 2007-07-05 2010-06-15 Baxter International Inc. Dialysis system having supply container autoconnection
JP5376480B1 (ja) * 2012-10-10 2013-12-25 富田製薬株式会社 酢酸及び酢酸塩を含む透析用ａ剤、及びそれを用いた２剤型透析用剤
JP6345952B2 (ja) * 2014-03-13 2018-06-20 ナチュラン・インターナショナル有限会社 医療用容器
EP2965747A1 (en) 2014-07-10 2016-01-13 Nipro Renal Solutions Spain SRL Dialysate acid precursor composition enriched with phosphorous
DE102014013885A1 (de) * 2014-09-18 2016-03-24 Fresenius Medical Care Deutschland Gmbh Dialyselösung
CN104586884A (zh) * 2015-01-09 2015-05-06 李淑秀 新型血液透析浓缩液
CA3022949A1 (en) 2016-05-06 2017-11-09 Gambro Lundia Ab Systems and methods for peritoneal dialysis having point of use dialysis fluid preparation including testing thereof
EP3508840A4 (en) * 2016-08-30 2020-04-15 Nipro Corporation STANDARD REAGENT KIT FOR DIALYSIS LIQUID ANALYSIS AND AQUEOUS SOLUTION FOR STANDARD REAGENTS, DIALYSIS LIQUID, AND LIQUID REFILL FOR ARTIFICIAL KIDNEY
JP6958265B2 (ja) * 2016-11-09 2021-11-02 ニプロ株式会社 血液ろ過用補充液
JP6946952B2 (ja) * 2016-11-09 2021-10-13 ニプロ株式会社 血液ろ過用補充液
JP7246203B2 (ja) * 2018-02-23 2023-03-27 ニプロ株式会社 血液ろ過用補充液
WO2020133198A1 (en) * 2018-12-28 2020-07-02 Fresenius Medical Care R&D (Shanghai) Co., Ltd. Stabilized aqueous hemofiltration basic solution, dialysis solution and corresponding kit

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JPH033504B2 (ja) 1983-09-02 1991-01-18 Sagami Maikuro Kk
JPH11197240A (ja) 1997-10-31 1999-07-27 Fresenius Medical Care Deutsche Gmbh 腹膜透析用溶液
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JPH033504B2 (ja) 1983-09-02 1991-01-18 Sagami Maikuro Kk
JPH11197240A (ja) 1997-10-31 1999-07-27 Fresenius Medical Care Deutsche Gmbh 腹膜透析用溶液
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013138827A (ja) * 2011-12-06 2013-07-18 Tomita Pharmaceutical Co Ltd 重炭酸透析剤
WO2017038099A1 (ja) * 2015-09-04 2017-03-09 ニプロ株式会社 標準液充填体およびその利用
JPWO2017038099A1 (ja) * 2015-09-04 2018-07-19 ニプロ株式会社 標準液充填体およびその利用
JP2021073048A (ja) * 2015-09-04 2021-05-13 ニプロ株式会社 標準液充填体およびその利用
JP7107400B2 (ja) 2015-09-04 2022-07-27 ニプロ株式会社 標準液充填体およびその利用
JP7395288B2 (ja) 2019-08-30 2023-12-11 ポッカサッポロフード＆ビバレッジ株式会社 アンジオテンシンＩＩＴｙｐｅ１受容体拮抗剤

Also Published As

Publication number Publication date
CN101888846B (zh) 2013-02-27
US9795636B2 (en) 2017-10-24
JP5329420B2 (ja) 2013-10-30
AU2008307966A1 (en) 2009-04-09
KR101183965B1 (ko) 2012-09-18
EP2206504A4 (en) 2014-02-12
US20100206753A1 (en) 2010-08-19
JP5636075B2 (ja) 2014-12-03
CA2701249C (en) 2014-12-16
CA2701249A1 (en) 2009-04-09
US8771749B2 (en) 2014-07-08
AU2008307966B2 (en) 2011-09-29
JPWO2009044919A1 (ja) 2011-02-17
JP2013224327A (ja) 2013-10-31
US20140335198A1 (en) 2014-11-13
CN101888846A (zh) 2010-11-17
KR20100075579A (ko) 2010-07-02
EP2206504A1 (en) 2010-07-14

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