WO2009028643A1 - カロテノイドの製造方法 - Google Patents

カロテノイドの製造方法 Download PDF

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Publication number
WO2009028643A1
WO2009028643A1 PCT/JP2008/065494 JP2008065494W WO2009028643A1 WO 2009028643 A1 WO2009028643 A1 WO 2009028643A1 JP 2008065494 W JP2008065494 W JP 2008065494W WO 2009028643 A1 WO2009028643 A1 WO 2009028643A1
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WO
WIPO (PCT)
Prior art keywords
composition
lower alcohol
production
extract
combination
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Application number
PCT/JP2008/065494
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English (en)
French (fr)
Inventor
Toshiyuki Takahashi
Shotaro Uchizawa
Hideyuki Dohi
Kentaro Shimizu
Tomoyuki Ishizaki
Original Assignee
Nippon Oil Corporation
Asahi Kasei Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Oil Corporation, Asahi Kasei Pharma Corporation filed Critical Nippon Oil Corporation
Priority to KR1020107006771A priority Critical patent/KR101154907B1/ko
Priority to US12/675,174 priority patent/US10701957B2/en
Priority to AU2008292356A priority patent/AU2008292356B2/en
Priority to CN2008801048265A priority patent/CN101815790B/zh
Priority to CA2697670A priority patent/CA2697670C/en
Priority to EP08828773.5A priority patent/EP2192191B1/en
Publication of WO2009028643A1 publication Critical patent/WO2009028643A1/ja

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40—Colouring or decolouring of foods
    • A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B61/00—Dyes of natural origin prepared from natural sources, e.g. vegetable sources
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　本発明によって、高純度、安価かつ安全なカロテノイド高含有組成物及びその工業的な製造方法が提供される。さらには該組成物を含有する機能性食品、医薬組成物、又は化粧品も提供される。また、本発明は、微生物培養物を、低くとも８０°Cの低級アルコール類または、低くとも８０°Cの水と低級アルコール類との組み合わせを用いて抽出処理した後、抽出液から得た沈殿物を低級アルコール類と水を組み合わせたもので洗浄・濾過することを特徴とするカロテノイド含量が少なくとも８０％の組成物の製造方法を提供する。 
PCT/JP2008/065494 2007-08-29 2008-08-29 カロテノイドの製造方法 WO2009028643A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1020107006771A KR101154907B1 (ko) 2007-08-29 2008-08-29 카로테노이드의 제조 방법
US12/675,174 US10701957B2 (en) 2007-08-29 2008-08-29 Method for production of carotenoid
AU2008292356A AU2008292356B2 (en) 2007-08-29 2008-08-29 Method for production of carotenoid
CN2008801048265A CN101815790B (zh) 2007-08-29 2008-08-29 类胡萝卜素的制造方法
CA2697670A CA2697670C (en) 2007-08-29 2008-08-29 Method for production of carotenoid
EP08828773.5A EP2192191B1 (en) 2007-08-29 2008-08-29 Method for production of carotenoid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-222476 2007-08-29
JP2007222476A JP4969370B2 (ja) 2007-08-29 2007-08-29 カロテノイドの製造方法

Publications (1)

Publication Number Publication Date
WO2009028643A1 true WO2009028643A1 (ja) 2009-03-05

Family

ID=40387354

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065494 WO2009028643A1 (ja) 2007-08-29 2008-08-29 カロテノイドの製造方法

Country Status (8)

Country Link
US (1) US10701957B2 (ja)
EP (1) EP2192191B1 (ja)
JP (1) JP4969370B2 (ja)
KR (1) KR101154907B1 (ja)
CN (1) CN101815790B (ja)
AU (1) AU2008292356B2 (ja)
CA (1) CA2697670C (ja)
WO (1) WO2009028643A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120029088A1 (en) * 2010-07-27 2012-02-02 Jx Nippon Oil & Energy Corporation Anti-anxiety composition
WO2012105632A1 (ja) * 2011-02-02 2012-08-09 Ｊｘ日鉱日石エネルギー株式会社 皮膚外用剤
WO2013002398A1 (ja) 2011-06-30 2013-01-03 株式会社カネカ カロテノイド組成物の製造方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8097761B2 (en) 2006-03-28 2012-01-17 Jx Nippon Oil & Energy Corporation Process for production of carotenoid
WO2012011589A1 (ja) * 2010-07-22 2012-01-26 株式会社カネカ 脂溶性生理活性物質の製造方法
CN102586377A (zh) * 2011-12-30 2012-07-18 秦皇岛大惠生物技术有限公司 一种含类胡萝卜素单体的浓缩物及其制备方法与它的用途
WO2014054669A1 (ja) 2012-10-02 2014-04-10 株式会社ダイセル カロテノイド含有組成物の製造方法及びカロテノイド含有組成物
JP2016032430A (ja) * 2012-12-27 2016-03-10 株式会社カネカ カロテノイド組成物の製造方法
KR101477204B1 (ko) * 2013-04-19 2014-12-29 한국에너지기술연구원 헤마토코커스 플루비알리스로부터 아스타잔틴과 지질의 동시 생산방법
CN104447464B (zh) * 2013-09-24 2016-11-23 浙江医药股份有限公司新昌制药厂 一种植物来源含天然虾青素的类胡萝卜素化合物及其制备方法和组合物
JP6218624B2 (ja) * 2014-01-30 2017-10-25 Ｊｘｔｇエネルギー株式会社 虚血性疾患を予防するための薬剤
JP7496743B2 (ja) 2019-09-09 2024-06-07 Ｅｎｅｏｓ株式会社 シス型キサントフィルの抽出方法

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Publication number Priority date Publication date Assignee Title
US5712110A (en) 1987-04-15 1998-01-27 Gist-Brocades, B.V. Astaxanthin-producing yeast cells methods for their preparation and their use
JPH01156346A (ja) 1987-12-15 1989-06-19 Mitsui Petrochem Ind Ltd ポリオレフィン組成物
JPH07242621A (ja) 1994-03-02 1995-09-19 Nippon Oil Co Ltd カロチノイド化合物の抽出方法
JPH0889280A (ja) 1994-09-27 1996-04-09 Nippon Oil Co Ltd バクテリア菌体からのカロチノイド化合物の抽出方法
JPH08253695A (ja) 1995-03-16 1996-10-01 Nippon Oil Co Ltd キサントフィル化合物の精製方法
JPH10276721A (ja) 1997-04-11 1998-10-20 Suntory Ltd アスタキサンチン含有飲食物
JPH1156346A (ja) * 1997-08-27 1999-03-02 Higashimaru Shoyu Kk アスタキサンチン含有ヘマトコッカス藻体とその抽出物
US6706278B1 (en) 1999-09-30 2004-03-16 Nippon Mitsubishi Oil Corporation Pigment- containing materials to be added to feeds
WO2001046133A1 (en) 1999-12-21 2001-06-28 Fermentron Ltd. Processes for extracting carotenoids and for preparing feed materials
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JP2002218994A (ja) 2001-01-26 2002-08-06 Fuji Chem Ind Co Ltd 粗キサントフィル類の精製法
JP2003144188A (ja) 2001-11-16 2003-05-20 Fuji Chem Ind Co Ltd キサントフィル遊離体の新規な製造方法および精製方法
JP2004041147A (ja) 2002-07-16 2004-02-12 Takeda Shiki Kk アスタキサンチンの抽出方法
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US20120029088A1 (en) * 2010-07-27 2012-02-02 Jx Nippon Oil & Energy Corporation Anti-anxiety composition
WO2012105632A1 (ja) * 2011-02-02 2012-08-09 Ｊｘ日鉱日石エネルギー株式会社 皮膚外用剤
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WO2013002398A1 (ja) 2011-06-30 2013-01-03 株式会社カネカ カロテノイド組成物の製造方法
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JPWO2013002398A1 (ja) * 2011-06-30 2015-02-23 株式会社カネカ カロテノイド組成物の製造方法
US9096508B2 (en) 2011-06-30 2015-08-04 Kaneka Corporation Method for producing carotenoid composition

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EP2192191A4 (en) 2010-09-01
US20100291251A1 (en) 2010-11-18
CA2697670A1 (en) 2009-03-05
EP2192191A1 (en) 2010-06-02
AU2008292356B2 (en) 2012-09-06
US10701957B2 (en) 2020-07-07
AU2008292356A1 (en) 2009-03-05
JP4969370B2 (ja) 2012-07-04
EP2192191B1 (en) 2017-03-15
JP2009050237A (ja) 2009-03-12
KR20100063746A (ko) 2010-06-11
CN101815790A (zh) 2010-08-25
KR101154907B1 (ko) 2012-06-13
CN101815790B (zh) 2013-11-06
CA2697670C (en) 2015-11-03

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