WO2009022702A1 - ピリピロペン誘導体の製造法およびその製造中間体 - Google Patents

ピリピロペン誘導体の製造法およびその製造中間体 Download PDF

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Publication number
WO2009022702A1
WO2009022702A1 PCT/JP2008/064520 JP2008064520W WO2009022702A1 WO 2009022702 A1 WO2009022702 A1 WO 2009022702A1 JP 2008064520 W JP2008064520 W JP 2008064520W WO 2009022702 A1 WO2009022702 A1 WO 2009022702A1
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WO
WIPO (PCT)
Prior art keywords
group
substituted
halogen atom
branched
linear
Prior art date
Application number
PCT/JP2008/064520
Other languages
English (en)
French (fr)
Inventor
Kimihiko Goto
Kazumi Yamamoto
Masayo Sakai
Masaaki Mitomi
Takashi Ando
Original Assignee
Meiji Seika Kaisha, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/733,113 priority Critical patent/US8263778B2/en
Priority to NZ583710A priority patent/NZ583710A/en
Priority to EP08827512A priority patent/EP2186815A4/en
Priority to JP2009528134A priority patent/JP5544553B2/ja
Priority to AU2008287799A priority patent/AU2008287799B2/en
Priority to MX2010001609A priority patent/MX2010001609A/es
Priority to BRPI0814980-1A priority patent/BRPI0814980B1/pt
Priority to RU2010109368/04A priority patent/RU2494101C2/ru
Application filed by Meiji Seika Kaisha, Ltd. filed Critical Meiji Seika Kaisha, Ltd.
Priority to CN2008801111451A priority patent/CN101821272B/zh
Priority to CA2696039A priority patent/CA2696039C/en
Publication of WO2009022702A1 publication Critical patent/WO2009022702A1/ja
Priority to IL203698A priority patent/IL203698B/en
Priority to ZA2010/01744A priority patent/ZA201001744B/en
Priority to US13/572,971 priority patent/US8759529B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

　下記の式Ｃ： 　　【化１】 ［式中、Ｒ’は、直鎖、分岐鎖、または環状のＣ２－６アルキルカルボニル基を表す］ で表される化合物Ｃを製造する方法であって、７位水酸基の保護基として、Ｒ１ｂ［Ｒ１ｂは、ホルミル基、置換されていてもよい直鎖Ｃ１－４アルキルカルボニル基、置換されていてもよいベンジル基、ハロゲン原子で置換されていてもよい－ＳｉＲ３Ｒ４Ｒ５基（ここで、Ｒ３、Ｒ４およびＲ５は、互いに独立して、直鎖もしくは分岐鎖状のＣ１－６アルキル基、またはフェニル基を表す）、ハロゲン原子で置換されていてもよいＣ１－６アルキルオキシ－Ｃ１－６アルキル基、ハロゲン原子で置換されていてもよいＣ１－６アルキルチオ－Ｃ１－６アルキル基、ハロゲン原子で置換されていてもよい直鎖、分岐鎖もしくは環状のＣ１－４アルキル基（この基が分岐鎖または環状であるときは、Ｃ３－４アルキル基）、ハロゲン原子で置換されていてもよいＣ２－６アルケニル基、ハロゲン原子で置換されていてもよいＣ２－６アルキニル基、または置換されていてもよい飽和もしくは不飽和の５もしくは６員の複素環基を表す］を用いる方法が開示される。この方法によれば、１位および１１位にアシルオキシ基を有し、７位に水酸基を有する、害虫防除剤として有用なピリピロペン誘導体を高収率で製造することが可能となる。
PCT/JP2008/064520 2007-08-13 2008-08-13 ピリピロペン誘導体の製造法およびその製造中間体 WO2009022702A1 (ja)

Priority Applications (13)

Application Number Priority Date Filing Date Title
BRPI0814980-1A BRPI0814980B1 (pt) 2007-08-13 2008-08-13 Processo para produzir um composto, e, composto.
EP08827512A EP2186815A4 (en) 2007-08-13 2008-08-13 PROCESS FOR PREPARING A PYRIPYROPEN DERIVATIVE AND INTERMEDIATE PRODUCT
JP2009528134A JP5544553B2 (ja) 2007-08-13 2008-08-13 ピリピロペン誘導体の製造法およびその製造中間体
AU2008287799A AU2008287799B2 (en) 2007-08-13 2008-08-13 Method for producing pyripyropene derivative and production intermediate thereof
MX2010001609A MX2010001609A (es) 2007-08-13 2008-08-13 Proceso para producir derivados de piripiropeno e intermediarios para la produccion de los mismos.
US12/733,113 US8263778B2 (en) 2007-08-13 2008-08-13 Process for producing pyripyropene derivatives and intermediates for the production thereof
RU2010109368/04A RU2494101C2 (ru) 2007-08-13 2008-08-13 Способ получения пирипиропенных производных и промежуточных продуктов для их получения
NZ583710A NZ583710A (en) 2007-08-13 2008-08-13 Method for producing pyripyropene derivative and production intermediate thereof
CN2008801111451A CN101821272B (zh) 2007-08-13 2008-08-13 生产pyripyropene衍生物的方法及其生产中间体
CA2696039A CA2696039C (en) 2007-08-13 2008-08-13 Process for producing pyripyropene derivatives and intermediates for the production thereof
IL203698A IL203698B (en) 2007-08-13 2010-02-03 A process for the preparation of pyripyrophane precursors and intermediates in the process for their preparation
ZA2010/01744A ZA201001744B (en) 2007-08-13 2010-03-11 Process for producing pyripyropene derivatives and intermediates for the production thereof
US13/572,971 US8759529B2 (en) 2007-08-13 2012-08-13 Process for producing pyripyropene derivatives and intermediates for the production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-210804 2007-08-13
JP2007210804 2007-08-13

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/733,113 A-371-Of-International US8263778B2 (en) 2007-08-13 2008-08-13 Process for producing pyripyropene derivatives and intermediates for the production thereof
US13/572,971 Division US8759529B2 (en) 2007-08-13 2012-08-13 Process for producing pyripyropene derivatives and intermediates for the production thereof

Publications (1)

Publication Number Publication Date
WO2009022702A1 true WO2009022702A1 (ja) 2009-02-19

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PCT/JP2008/064520 WO2009022702A1 (ja) 2007-08-13 2008-08-13 ピリピロペン誘導体の製造法およびその製造中間体

Country Status (16)

Country Link
US (2) US8263778B2 (ja)
EP (2) EP2592084B8 (ja)
JP (1) JP5544553B2 (ja)
KR (1) KR101570887B1 (ja)
CN (1) CN101821272B (ja)
AU (1) AU2008287799B2 (ja)
BR (1) BRPI0814980B1 (ja)
CA (1) CA2696039C (ja)
EC (1) ECSP10010019A (ja)
IL (1) IL203698B (ja)
MX (1) MX2010001609A (ja)
NZ (1) NZ583710A (ja)
RU (1) RU2494101C2 (ja)
TW (1) TWI422333B (ja)
WO (1) WO2009022702A1 (ja)
ZA (1) ZA201001744B (ja)

Cited By (16)

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Publication number Priority date Publication date Assignee Title
WO2010010955A1 (ja) 2008-07-24 2010-01-28 明治製菓株式会社 ピリピロペンa生合成遺伝子
WO2010131676A1 (ja) 2009-05-13 2010-11-18 明治製菓株式会社 ピリピロペン誘導体の製造法
WO2010150739A1 (ja) * 2009-06-23 2010-12-29 学校法人北里研究所 Ａｃａｔ２阻害活性を示す水酸基含有ピリピロペン誘導体
WO2011093187A1 (ja) 2010-01-26 2011-08-04 明治製菓株式会社 酵素法によるピリピロペン誘導体の製造方法
WO2011108155A1 (en) 2010-03-01 2011-09-09 Meiji Seika Kaisha, Ltd. Process for producing pyripyropene derivatives
WO2011147952A1 (en) 2010-05-28 2011-12-01 Basf Se Pesticidal mixtures
WO2011147953A1 (en) 2010-05-28 2011-12-01 Basf Se Pesticidal mixtures
WO2011148886A1 (ja) 2010-05-24 2011-12-01 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 有害生物防除剤
WO2011158879A1 (ja) * 2010-06-16 2011-12-22 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 害虫防除用組成物
WO2011161131A1 (en) 2010-06-25 2011-12-29 Basf Se Herbicidal mixtures
WO2011161132A1 (en) 2010-06-25 2011-12-29 Basf Se Pesticidal mixtures
CN104017839A (zh) * 2010-01-26 2014-09-03 明治制果药业株式会社 生产啶南平的方法
JP2015511596A (ja) * 2012-03-12 2015-04-20 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ピリピロペン殺虫剤の水性懸濁濃厚製剤の調製方法
US9090924B2 (en) 2010-01-26 2015-07-28 Meiji Seika Pharma Co., Ltd. Nucleic acid construct comprising pyripyropene biosynthetic gene cluster and marker gene
JP2018138579A (ja) * 2013-01-16 2018-09-06 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ピリピロペン化合物の製造方法
CN110294765A (zh) * 2010-09-14 2019-10-01 巴斯夫欧洲公司 含有啶南平杀虫剂和助剂的组合物

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US9723834B2 (en) 2010-09-14 2017-08-08 Basf Se Composition containing a pyripyropene insecticide and a base
KR102055551B1 (ko) 2012-03-12 2019-12-13 바스프 에스이 피리피로펜 살충제 ｉ 함유 액체 농축 제형
ES2566910T3 (es) 2012-03-12 2016-04-18 Basf Se Formulación de concentrado líquido que contiene un insecticida de piripiropeno II
CN104168770B (zh) 2012-03-13 2016-06-01 巴斯夫欧洲公司 含有啶南平杀虫剂的液体浓缩物配制剂iii
US9668470B2 (en) 2013-01-16 2017-06-06 Basf Se Method for producing a liquid emulsifiable formulation comprising a pyripyropene pesticide
CN104955335B (zh) * 2013-01-25 2018-02-13 巴斯夫欧洲公司 一种制备含水悬浮液浓缩物配制剂的方法
CN105102625A (zh) 2013-03-28 2015-11-25 巴斯夫欧洲公司 自干生物质制备啶南平
CN113735924A (zh) * 2021-09-01 2021-12-03 河北威远生物化工有限公司 一种23-酮阿维菌素B2a/B2b衍生物的制备方法

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US9315785B2 (en) 2008-07-24 2016-04-19 Meiji Seika Pharma Co., Ltd. Pyripyropene a biosynthetic gene
WO2010010955A1 (ja) 2008-07-24 2010-01-28 明治製菓株式会社 ピリピロペンa生合成遺伝子
US8557550B2 (en) 2008-07-24 2013-10-15 Meija Seika Pharma Co., Ltd. Pyripyropene a biosynthetic gene
EP2426124A1 (en) * 2009-05-13 2012-03-07 Meiji Seika Pharma Co., Ltd. Process for producing pyripyropene derivative
EP2426124A4 (en) * 2009-05-13 2012-03-07 Meiji Seika Pharma Co Ltd PROCESS FOR PREPARING PYRIPYROPEN DERIVATIVES
WO2010131676A1 (ja) 2009-05-13 2010-11-18 明治製菓株式会社 ピリピロペン誘導体の製造法
RU2532441C2 (ru) * 2009-05-13 2014-11-10 Мейдзи Сейка Фарма Ко., Лтд. Способ получения производных пирипиропена
US8853413B2 (en) 2009-05-13 2014-10-07 Meiji Seika Pharma Co., Ltd. Process for producing pyripyropene derivatives
JP5781432B2 (ja) * 2009-05-13 2015-09-24 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ピリピロペン誘導体の製造法
CN102348706A (zh) * 2009-05-13 2012-02-08 明治制果药业株式会社 生产啶南平衍生物的方法
JP5554330B2 (ja) * 2009-06-23 2014-07-23 学校法人北里研究所 Ａｃａｔ２阻害活性を示す水酸基含有ピリピロペン誘導体
WO2010150739A1 (ja) * 2009-06-23 2010-12-29 学校法人北里研究所 Ａｃａｔ２阻害活性を示す水酸基含有ピリピロペン誘導体
CN104017839A (zh) * 2010-01-26 2014-09-03 明治制果药业株式会社 生产啶南平的方法
US9169504B2 (en) 2010-01-26 2015-10-27 Meiji Seika Pharma Co., Ltd. Method for producing pyripyropene
WO2011093187A1 (ja) 2010-01-26 2011-08-04 明治製菓株式会社 酵素法によるピリピロペン誘導体の製造方法
CN104017839B (zh) * 2010-01-26 2017-01-18 明治制果药业株式会社 生产啶南平的方法
US9090924B2 (en) 2010-01-26 2015-07-28 Meiji Seika Pharma Co., Ltd. Nucleic acid construct comprising pyripyropene biosynthetic gene cluster and marker gene
CN102947312B (zh) * 2010-03-01 2015-05-27 明治制果药业株式会社 生产啶南平衍生物的方法
CN102947312A (zh) * 2010-03-01 2013-02-27 明治制果药业株式会社 生产啶南平衍生物的方法
RU2578605C2 (ru) * 2010-03-01 2016-03-27 Мейдзи Сейка Фарма Ко., Лтд. Способ получения производных пирипиропена
WO2011108155A1 (en) 2010-03-01 2011-09-09 Meiji Seika Kaisha, Ltd. Process for producing pyripyropene derivatives
US8853414B2 (en) 2010-03-01 2014-10-07 Meiji Seika Pharma Co., Ltd. Process for producing pyripyropene derivatives
EP2578084A1 (en) * 2010-05-24 2013-04-10 Meiji Seika Pharma Co., Ltd. Noxious organism control agent
EP2578084A4 (en) * 2010-05-24 2014-04-23 Meiji Seika Pharma Co Ltd MEANS OF COMBATING HARMFUL ORGANISMS
WO2011148886A1 (ja) 2010-05-24 2011-12-01 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 有害生物防除剤
US9125416B2 (en) 2010-05-28 2015-09-08 Basf Se Pesticidal mixtures
US8962524B2 (en) 2010-05-28 2015-02-24 Basf Se Pesticidal mixtures
WO2011147953A1 (en) 2010-05-28 2011-12-01 Basf Se Pesticidal mixtures
WO2011147952A1 (en) 2010-05-28 2011-12-01 Basf Se Pesticidal mixtures
US9907309B2 (en) 2010-05-28 2018-03-06 Basf Se Pesticidal mixtures
WO2011158879A1 (ja) * 2010-06-16 2011-12-22 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 害虫防除用組成物
WO2011161132A1 (en) 2010-06-25 2011-12-29 Basf Se Pesticidal mixtures
WO2011161131A1 (en) 2010-06-25 2011-12-29 Basf Se Herbicidal mixtures
CN110294765A (zh) * 2010-09-14 2019-10-01 巴斯夫欧洲公司 含有啶南平杀虫剂和助剂的组合物
JP2015511596A (ja) * 2012-03-12 2015-04-20 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ピリピロペン殺虫剤の水性懸濁濃厚製剤の調製方法
JP2018138579A (ja) * 2013-01-16 2018-09-06 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ピリピロペン化合物の製造方法

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AU2008287799B2 (en) 2013-10-31
AU2008287799A1 (en) 2009-02-19
CA2696039C (en) 2015-11-24
BRPI0814980A8 (pt) 2016-07-26
CN101821272A (zh) 2010-09-01
KR101570887B1 (ko) 2015-11-20
MX2010001609A (es) 2010-03-15
US8759529B2 (en) 2014-06-24
CA2696039A1 (en) 2009-02-19
EP2186815A4 (en) 2012-01-25
EP2592084B8 (en) 2014-08-27
CN101821272B (zh) 2013-03-27
EP2592084A1 (en) 2013-05-15
BRPI0814980A2 (pt) 2015-02-03
ZA201001744B (en) 2011-06-29
TWI422333B (zh) 2014-01-11
EP2592084B1 (en) 2014-07-09
US20100160640A1 (en) 2010-06-24
US8263778B2 (en) 2012-09-11
KR20100051857A (ko) 2010-05-18
JPWO2009022702A1 (ja) 2010-11-18
EP2186815A1 (en) 2010-05-19
ECSP10010019A (es) 2010-06-29
IL203698B (en) 2018-04-30
BRPI0814980B1 (pt) 2022-05-31
NZ583710A (en) 2012-03-30
US20120330021A1 (en) 2012-12-27
JP5544553B2 (ja) 2014-07-09
RU2494101C2 (ru) 2013-09-27
TW200915987A (en) 2009-04-16
RU2010109368A (ru) 2011-09-20

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