WO2009001764A1 - 統合失調症の治療または予防剤 - Google Patents

統合失調症の治療または予防剤 Download PDF

Info

Publication number
WO2009001764A1
WO2009001764A1 PCT/JP2008/061309 JP2008061309W WO2009001764A1 WO 2009001764 A1 WO2009001764 A1 WO 2009001764A1 JP 2008061309 W JP2008061309 W JP 2008061309W WO 2009001764 A1 WO2009001764 A1 WO 2009001764A1
Authority
WO
WIPO (PCT)
Prior art keywords
dysfunction syndrome
remedy
preventive
integration dysfunction
integration
Prior art date
Application number
PCT/JP2008/061309
Other languages
English (en)
French (fr)
Inventor
Satoru Yoshikawa
Hidenori Mochizuki
Original Assignee
Toray Industries, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries, Inc. filed Critical Toray Industries, Inc.
Priority to PL08777453T priority Critical patent/PL2168580T3/pl
Priority to EP08777453.5A priority patent/EP2168580B1/en
Priority to CA2691220A priority patent/CA2691220C/en
Priority to AU2008268202A priority patent/AU2008268202B2/en
Priority to US12/664,686 priority patent/US8183256B2/en
Priority to CN2008801034116A priority patent/CN101778632B/zh
Priority to JP2009520550A priority patent/JP5343848B2/ja
Priority to ES08777453.5T priority patent/ES2555785T3/es
Priority to KR20097026917A priority patent/KR101492029B1/ko
Priority to MX2009014181A priority patent/MX2009014181A/es
Publication of WO2009001764A1 publication Critical patent/WO2009001764A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

　本発明は、統合失調症の特に陽性症状を治療することができ、また、統合失調症の一症状である認知障害等に関わる情報処理障害を引き起こさない、統合失調症の治療または予防剤を提供することを目的とする。 　すなわち、本発明は、下記化合物１に代表される特定のモルヒナン骨格を有する化合物、またはその薬理学的に許容される酸付加塩を有効成分とする統合失調症の治療または予防剤を提供した。 【化１】
PCT/JP2008/061309 2007-06-22 2008-06-20 統合失調症の治療または予防剤 WO2009001764A1 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
PL08777453T PL2168580T3 (pl) 2007-06-22 2008-06-20 Środek do leczenia lub zapobiegania schizofrenii
EP08777453.5A EP2168580B1 (en) 2007-06-22 2008-06-20 Remedy or preventive for schizophrenia
CA2691220A CA2691220C (en) 2007-06-22 2008-06-20 Remedy or preventive for integration dysfunction syndrome
AU2008268202A AU2008268202B2 (en) 2007-06-22 2008-06-20 Remedy or preventive for integration dysfunction syndrome
US12/664,686 US8183256B2 (en) 2007-06-22 2008-06-20 Remedy or preventive for integration dysfunction syndrome
CN2008801034116A CN101778632B (zh) 2007-06-22 2008-06-20 综合失调症的治疗或预防药
JP2009520550A JP5343848B2 (ja) 2007-06-22 2008-06-20 統合失調症の治療または予防剤
ES08777453.5T ES2555785T3 (es) 2007-06-22 2008-06-20 Remedio o preventivo para esquizofrenia
KR20097026917A KR101492029B1 (ko) 2007-06-22 2008-06-20 통합 실조증의 치료 또는 예방제
MX2009014181A MX2009014181A (es) 2007-06-22 2008-06-20 Remedio o preventivo para sindrome de disfuncion de integracion.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-164868 2007-06-22
JP2007164868 2007-06-22

Publications (1)

Publication Number Publication Date
WO2009001764A1 true WO2009001764A1 (ja) 2008-12-31

Family

ID=40185582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061309 WO2009001764A1 (ja) 2007-06-22 2008-06-20 統合失調症の治療または予防剤

Country Status (11)

Country Link
US (1) US8183256B2 (ja)
EP (1) EP2168580B1 (ja)
JP (1) JP5343848B2 (ja)
KR (1) KR101492029B1 (ja)
CN (1) CN101778632B (ja)
AU (1) AU2008268202B2 (ja)
CA (1) CA2691220C (ja)
ES (1) ES2555785T3 (ja)
MX (1) MX2009014181A (ja)
PL (1) PL2168580T3 (ja)
WO (1) WO2009001764A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011093441A1 (ja) 2010-01-29 2011-08-04 東レ株式会社 胆道疾患の治療又は予防剤
WO2012105475A1 (ja) 2011-01-31 2012-08-09 東レ株式会社 悪液質の治療又は予防剤

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI449704B (zh) * 2013-04-26 2014-08-21 Everlight Chem Ind Corp 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011289A1 (fr) * 1997-09-02 1999-03-11 Toray Industries, Inc. Remedes contre la toxicomanie
JP2000169476A (ja) * 1998-12-09 2000-06-20 Banyu Pharmaceut Co Ltd ４−オキソイミダゾリジン−５−スピロ−含窒素複素環式化合物
WO2005085228A1 (ja) * 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd. シクロアルカノピリジン誘導体
JP2005289886A (ja) * 2004-03-31 2005-10-20 Satoko Sawaguchi 自傷行動抑制薬
WO2007037513A1 (ja) * 2005-09-30 2007-04-05 Banyu Pharmaceutical Co., Ltd. アリール置換含窒素複素環化合物
WO2007100775A2 (en) * 2006-02-27 2007-09-07 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01149788A (ja) 1987-12-08 1989-06-12 Chugai Pharmaceut Co Ltd 新規なモルヒネ誘導体
DE69321525T2 (de) 1992-01-23 1999-03-04 Toray Industries Morphinan-derivate und medizinische verwendung
DE69413933T2 (de) * 1993-06-30 1999-04-08 Toray Industries Antitussiva
EP0661283B1 (en) 1993-07-19 1998-10-21 Toray Industries, Inc. Brain cell protective
CN1291717C (zh) 1996-11-25 2006-12-27 东丽株式会社 止痒药物
AU6117298A (en) 1997-07-25 1999-02-16 Toray Industries, Inc. Hyponatremia remedies
JPH1192376A (ja) * 1997-09-17 1999-04-06 Toray Ind Inc ニコチン依存症治療剤
JP2000053572A (ja) 1998-08-11 2000-02-22 Toray Ind Inc ＯＲＬ１（ｏｐｉｏｉｄ ｏｒｐｈａｎ）受容体拮抗薬
US6476208B1 (en) * 1998-10-13 2002-11-05 Genset Schizophrenia associated genes, proteins and biallelic markers
JP4867123B2 (ja) 1999-08-24 2012-02-01 東レ株式会社 神経因性疼痛治療剤および神経因性疼痛のモデル動物
PT1380306E (pt) 2001-03-30 2009-05-25 Toray Industries Medicamentos para psiconeurose
US7652025B2 (en) 2001-05-08 2010-01-26 Toray Industries, Inc. Remedies for sepsis
US7553908B1 (en) * 2003-01-30 2009-06-30 Prc Desoto International, Inc. Preformed compositions in shaped form comprising polymer blends
AU2005286733B2 (en) * 2004-09-23 2009-11-05 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
CN101137658B (zh) 2005-03-10 2011-06-08 东丽株式会社 用于与多发性硬化症伴随的搔痒的止痒剂

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011289A1 (fr) * 1997-09-02 1999-03-11 Toray Industries, Inc. Remedes contre la toxicomanie
JP2000169476A (ja) * 1998-12-09 2000-06-20 Banyu Pharmaceut Co Ltd ４−オキソイミダゾリジン−５−スピロ−含窒素複素環式化合物
WO2005085228A1 (ja) * 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd. シクロアルカノピリジン誘導体
JP2005289886A (ja) * 2004-03-31 2005-10-20 Satoko Sawaguchi 自傷行動抑制薬
WO2007037513A1 (ja) * 2005-09-30 2007-04-05 Banyu Pharmaceutical Co., Ltd. アリール置換含窒素複素環化合物
WO2007100775A2 (en) * 2006-02-27 2007-09-07 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GAGLIARDI S. ET AL.: "Morphinan derivatives-A review of the recent patent literature", IDRUGS, vol. 6, no. 2, 2003, pages 129 - 137, XP008126753 *
IZENWASSER S. ET AL.: "Characterization of kappa-opioid receptor binding in human insular cortex", LIFE SCIENCES, vol. 65, no. 9, 1999, pages 857 - 862, XP008126754 *
MARGOLIS E.B. ET AL.: "Kappa opioids selectively control dopaminergic Neurons projecting to the prefrontal cortex", PNAS, vol. 103, no. 8, 21 February 2006 (2006-02-21), pages 2938 - 2942, XP008126746 *
TANAKA C. AND KATO R.: "NEW Yakurigaku, revised 3rd edition", 25 November 1996, NANKODO CO., LTD., pages: 268 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011093441A1 (ja) 2010-01-29 2011-08-04 東レ株式会社 胆道疾患の治療又は予防剤
US10131672B2 (en) 2010-01-29 2018-11-20 Toray Industries, Inc. Therapeutic or prophylactic agent for biliary diseases
WO2012105475A1 (ja) 2011-01-31 2012-08-09 東レ株式会社 悪液質の治療又は予防剤
US9006262B2 (en) 2011-01-31 2015-04-14 Toray Industries, Inc. Therapeutic or prophylactic agent for cachexia

Also Published As

Publication number Publication date
CN101778632B (zh) 2012-02-29
US20100160364A1 (en) 2010-06-24
CN101778632A (zh) 2010-07-14
KR101492029B1 (ko) 2015-02-10
AU2008268202A1 (en) 2008-12-31
ES2555785T3 (es) 2016-01-08
KR20100023001A (ko) 2010-03-03
PL2168580T3 (pl) 2016-06-30
EP2168580A1 (en) 2010-03-31
EP2168580B1 (en) 2015-12-02
CA2691220C (en) 2015-05-05
EP2168580A4 (en) 2011-08-17
JPWO2009001764A1 (ja) 2010-08-26
CA2691220A1 (en) 2008-12-31
MX2009014181A (es) 2010-03-04
US8183256B2 (en) 2012-05-22
AU2008268202B2 (en) 2012-12-20
JP5343848B2 (ja) 2013-11-13

Similar Documents

Publication Publication Date Title
WO2014049610A3 (en) Peptides as gip, glp-1 and glucagon receptors triple-agonist
WO2007149797A3 (en) Use of organic compounds
WO2009064460A3 (en) Gastrointestinal delivery systems
WO2011012816A3 (fr) Formulation pharmaceutique
TW200728307A (en) Novel spirochromanone derivatives
WO2008001195A3 (en) Novel processes for the preparation of dpp iv inhibitors
CR10458A (es) Compuestos de triazolopirazina utiles para el tratamiento de enfermedades degenerativas e inflamatorias
CR20110092A (es) Nuevos compuestos utiles para el tratamiento de enfermedades degenerativas e inflamatorias
WO2007087441A3 (en) Substituted aromatic compounds for inflammation and immune-related uses
WO2011041461A3 (en) Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2008044243A3 (en) Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
WO2009098715A3 (en) Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents
WO2007138472A3 (en) Triazolopyridazine derivatives
WO2008094992A3 (en) 2-aminopyridine derivatives useful as kinase inhibitors
WO2006124447A3 (en) Substituted n-arylpyrrolidines as selective androgen receptor modulators
WO2011011882A8 (en) Hydroxy fatty acid compounds and uses thereof for disease treatment and diagnosis
WO2018151861A8 (en) Methods of treating schizophrenia
CR9347A (es) Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos
WO2008143240A1 (ja) 特定の有機酸を含有する経口製剤並びに経口製剤の溶出性及び化学的安定性の改善方法
WO2011005811A8 (en) Combination therapy for the treatment of diabetes
WO2006074226A3 (en) Prevention of thrombotic disorders with active vitamin d compounds or mimics thereof
WO2007109230A3 (en) Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
WO2009016498A8 (en) Pyrimidine and pyridine derivatives and their pharmaceutical use and compositions
MX2009003125A (es) Tiazol pirazolopirimidinas como antagonistas de receptor de crf1.
WO2008048589A3 (en) Compounds and methods for treatment of hcv

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880103411.6

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08777453

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009520550

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2008268202

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2691220

Country of ref document: CA

Ref document number: 2008777453

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: MX/A/2009/014181

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 20097026917

Country of ref document: KR

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 12664686

Country of ref document: US

ENP Entry into the national phase

Ref document number: 2008268202

Country of ref document: AU

Date of ref document: 20080620

Kind code of ref document: A