ES2555785T3 - Remedio o preventivo para esquizofrenia - Google Patents
Remedio o preventivo para esquizofrenia Download PDFInfo
- Publication number
- ES2555785T3 ES2555785T3 ES08777453.5T ES08777453T ES2555785T3 ES 2555785 T3 ES2555785 T3 ES 2555785T3 ES 08777453 T ES08777453 T ES 08777453T ES 2555785 T3 ES2555785 T3 ES 2555785T3
- Authority
- ES
- Spain
- Prior art keywords
- schizophrenia
- line
- remedy
- preventive
- double
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 201000000980 schizophrenia Diseases 0.000 title abstract 2
- 230000003449 preventive effect Effects 0.000 title 1
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Agente terapéutico o profiláctico para su utilización en el tratamiento de la esquizofrenia, que comprende, como ingrediente eficaz, un compuesto representado mediante la fórmula general (I) a continuación:**Fórmula** en la que la línea doble, constituida por una línea de puntos y una línea continua, representa un doble enlace o un enlace sencillo, R1 representa cicloalquilalquilo C4-C7, R2 representa alquilo C1-C5 lineal o ramificado y B representa -CH>=CH-, o una sal de adición de ácido farmacéuticamente aceptable del mismo.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007164868 | 2007-06-22 | ||
JP2007164868 | 2007-06-22 | ||
PCT/JP2008/061309 WO2009001764A1 (ja) | 2007-06-22 | 2008-06-20 | 統合失調症の治療または予防剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2555785T3 true ES2555785T3 (es) | 2016-01-08 |
Family
ID=40185582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08777453.5T Active ES2555785T3 (es) | 2007-06-22 | 2008-06-20 | Remedio o preventivo para esquizofrenia |
Country Status (11)
Country | Link |
---|---|
US (1) | US8183256B2 (es) |
EP (1) | EP2168580B1 (es) |
JP (1) | JP5343848B2 (es) |
KR (1) | KR101492029B1 (es) |
CN (1) | CN101778632B (es) |
AU (1) | AU2008268202B2 (es) |
CA (1) | CA2691220C (es) |
ES (1) | ES2555785T3 (es) |
MX (1) | MX2009014181A (es) |
PL (1) | PL2168580T3 (es) |
WO (1) | WO2009001764A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5867081B2 (ja) | 2010-01-29 | 2016-02-24 | 東レ株式会社 | 胆道疾患の治療又は予防剤 |
ES2586655T3 (es) | 2011-01-31 | 2016-10-18 | Toray Industries, Inc. | (-)-17-(ciclopropilmetil)-3,14beta-dihidroxi-4,5alfa-epoxi-6beta-[N-metil-trans-3-(3-furil)acrilamido]morfinano para su utilización en el tratamiento o prevención de la caquexia por cáncer |
TWI449704B (zh) * | 2013-04-26 | 2014-08-21 | Everlight Chem Ind Corp | 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01149788A (ja) | 1987-12-08 | 1989-06-12 | Chugai Pharmaceut Co Ltd | 新規なモルヒネ誘導体 |
NZ246687A (en) | 1992-01-23 | 1996-12-20 | Toray Industries | Morphinan derivative and pharmaceutical compositions thereof |
CN1111900A (zh) * | 1993-06-30 | 1995-11-15 | 东丽株式会社 | 止咳药 |
EP0661283B1 (en) | 1993-07-19 | 1998-10-21 | Toray Industries, Inc. | Brain cell protective |
ATE291429T1 (de) | 1996-11-25 | 2005-04-15 | Toray Industries | Mittel gegen juckreiz |
AU6117298A (en) | 1997-07-25 | 1999-02-16 | Toray Industries, Inc. | Hyponatremia remedies |
JPH1192376A (ja) * | 1997-09-17 | 1999-04-06 | Toray Ind Inc | ニコチン依存症治療剤 |
JP4359711B2 (ja) | 1997-09-02 | 2009-11-04 | 東レ株式会社 | 薬物依存症治療薬 |
JP2000053572A (ja) | 1998-08-11 | 2000-02-22 | Toray Ind Inc | ORL1(opioid orphan)受容体拮抗薬 |
US6476208B1 (en) * | 1998-10-13 | 2002-11-05 | Genset | Schizophrenia associated genes, proteins and biallelic markers |
JP2000169476A (ja) | 1998-12-09 | 2000-06-20 | Banyu Pharmaceut Co Ltd | 4−オキソイミダゾリジン−5−スピロ−含窒素複素環式化合物 |
CN1204139C (zh) | 1999-08-24 | 2005-06-01 | 东丽株式会社 | 神经性疼痛治疗剂 |
WO2002078744A1 (fr) | 2001-03-30 | 2002-10-10 | Toray Industries, Inc. | Remedes contre la psychonevrose |
EP1402899A4 (en) | 2001-05-08 | 2009-03-11 | Toray Industries | MEANS FOR THE TREATMENT OF SEPSIS |
US7553908B1 (en) * | 2003-01-30 | 2009-06-30 | Prc Desoto International, Inc. | Preformed compositions in shaped form comprising polymer blends |
AU2005219785B2 (en) * | 2004-03-05 | 2010-05-27 | Msd K.K. | Cycloalkanopyridine derivative |
JP2005289886A (ja) * | 2004-03-31 | 2005-10-20 | Satoko Sawaguchi | 自傷行動抑制薬 |
CA2580694A1 (en) * | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
WO2006095836A1 (ja) | 2005-03-10 | 2006-09-14 | Toray Industries, Inc. | 多発性硬化症に伴う痒みに対する止痒剤 |
EP1935881B1 (en) | 2005-09-30 | 2012-04-04 | Msd K.K. | Aryl-substituted nitrogen-containing heterocyclic compound |
AU2007221135A1 (en) | 2006-02-27 | 2007-09-07 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
-
2008
- 2008-06-20 CA CA2691220A patent/CA2691220C/en not_active Expired - Fee Related
- 2008-06-20 KR KR20097026917A patent/KR101492029B1/ko active IP Right Grant
- 2008-06-20 JP JP2009520550A patent/JP5343848B2/ja not_active Expired - Fee Related
- 2008-06-20 AU AU2008268202A patent/AU2008268202B2/en not_active Ceased
- 2008-06-20 WO PCT/JP2008/061309 patent/WO2009001764A1/ja active Application Filing
- 2008-06-20 US US12/664,686 patent/US8183256B2/en not_active Expired - Fee Related
- 2008-06-20 CN CN2008801034116A patent/CN101778632B/zh not_active Expired - Fee Related
- 2008-06-20 PL PL08777453T patent/PL2168580T3/pl unknown
- 2008-06-20 EP EP08777453.5A patent/EP2168580B1/en not_active Not-in-force
- 2008-06-20 MX MX2009014181A patent/MX2009014181A/es active IP Right Grant
- 2008-06-20 ES ES08777453.5T patent/ES2555785T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
KR20100023001A (ko) | 2010-03-03 |
CN101778632A (zh) | 2010-07-14 |
EP2168580A4 (en) | 2011-08-17 |
EP2168580A1 (en) | 2010-03-31 |
CA2691220C (en) | 2015-05-05 |
JP5343848B2 (ja) | 2013-11-13 |
EP2168580B1 (en) | 2015-12-02 |
CA2691220A1 (en) | 2008-12-31 |
WO2009001764A1 (ja) | 2008-12-31 |
US8183256B2 (en) | 2012-05-22 |
US20100160364A1 (en) | 2010-06-24 |
AU2008268202A1 (en) | 2008-12-31 |
KR101492029B1 (ko) | 2015-02-10 |
PL2168580T3 (pl) | 2016-06-30 |
MX2009014181A (es) | 2010-03-04 |
CN101778632B (zh) | 2012-02-29 |
JPWO2009001764A1 (ja) | 2010-08-26 |
AU2008268202B2 (en) | 2012-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2557303T3 (es) | Agente terapéutico para la estenosis del canal espinal | |
AR072261A1 (es) | Derivados piperazin-pirazolicos, composiciones farmaceuticas que los contienen y usos de los mismos como agentes anticancerigenos. | |
ECSP055745A (es) | Derivados de 1-(4-bencil-piperazin-1-il)-3-fenil-propenona | |
CL2011001658A1 (es) | Compuestos derivados de sulfonamidas, moduladores de los canales de sodio; composición farmacéutica que los comprende; y su uso en el tratamiento del dolor. | |
SV2011004077A (es) | Derivados aminobutiricos sustituidos como inhibidores de neprilisina | |
DOP2012000011A (es) | Formulacion farmaceutica | |
UY30809A1 (es) | Derivados de n-[3-[4-fenil)piperidin-1-carbonil]fenil]sulfonamidas sustituidas, procesos de preparacion y aplicaciones | |
DOP2006000170A (es) | Nuevos derivados de espirocromanona | |
CR11510A (es) | Uso de un inhibidor de la gamma-secretasa para tratamiento del cancer | |
RS53209B (en) | PHARMACEUTICAL COMPOSITION FOR VIRAL HEPATITIS C PROTEASE INHIBITOR | |
CR9230A (es) | Uso de derivados del acido tetramico para el control de los insectos del genero de los hemipteros (sternorrhyncha) | |
AR062394A1 (es) | Uso de compuestos y derivados de 2,5-dihidroxibenceno para el tratamiento de la psoriasis | |
ECSP067044A (es) | Compuestos para el tratamiento de trastornos inflamatorios | |
AR079050A1 (es) | Compuestos benzoimidazolicos y sus usos | |
AR039936A1 (es) | Formulacion farmaceutica de liberacion modificada | |
CL2007003643A1 (es) | Composicion farmaceutica de azimilidina que comprende 0,5% a aproximadamente 2,5% (w/w) de agua; y uso para el tratamiento de arritmias cardiacas. | |
AR062401A1 (es) | Uso de derivados del 2,5-dihidroxibenceno para tratar dermatitis | |
CR9722A (es) | Derivados de benzilpiperazina y su uso medico | |
CO6321285A2 (es) | Uso de 3,11b-cis- dihidrotetrabenazina en el tratamiento de la esclerosis multiple y la mielitis autoinmunitaria | |
AR062390A1 (es) | Uso de derivados del 2,5-dihidroxibenceno para el tratamiento de hemangiomas o hemangioblastomas | |
AR078142A1 (es) | Compuestos inhibidores heteroarilicos biciclicos de pde4, las composiciones farmaceuticas que los contienen y el uso de los mismos para la preparacion de medicamentos. | |
CO2022008690A2 (es) | Compuestos heterocíclicos como inhibidores de delta-5 desaturasa y métodos de uso | |
ES2555785T3 (es) | Remedio o preventivo para esquizofrenia | |
AR064543A1 (es) | Uso de derivados de mononitrato de dianhidrohexita como agentes para el tratamiento de trastornos intestinales | |
AR039935A1 (es) | Formulacion farmaceutica de liberacion inmediata |