WO2008155920A1 - 肝細胞増殖促進作用を有する医薬 - Google Patents

肝細胞増殖促進作用を有する医薬 Download PDF

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Publication number
WO2008155920A1
WO2008155920A1 PCT/JP2008/001606 JP2008001606W WO2008155920A1 WO 2008155920 A1 WO2008155920 A1 WO 2008155920A1 JP 2008001606 W JP2008001606 W JP 2008001606W WO 2008155920 A1 WO2008155920 A1 WO 2008155920A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug
hepatocyte growth
effect
hepatic
promoting hepatocyte
Prior art date
Application number
PCT/JP2008/001606
Other languages
English (en)
French (fr)
Inventor
Masahiko Ogihara
Mitsutoshi Kimura
Naoto Ishibashi
Jun Kojima
Original Assignee
Josai University Corporation
Kowa Company, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Josai University Corporation, Kowa Company, Ltd. filed Critical Josai University Corporation
Priority to KR1020107001174A priority Critical patent/KR101457737B1/ko
Priority to EP08764189A priority patent/EP2168577A4/en
Priority to CN200880021286.4A priority patent/CN101720222B/zh
Priority to US12/665,342 priority patent/US20100184859A1/en
Priority to JP2009520336A priority patent/JP5352459B2/ja
Publication of WO2008155920A1 publication Critical patent/WO2008155920A1/ja
Priority to US13/464,432 priority patent/US8455546B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/745—Polymers of hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　この出願は、肝再生療法に用いる医薬に関する。 具体的には、数個の直鎖イソプレン単位を含む３，７，１１，１５－テトラメチル－２，４，６，１０，１４－ヘキサデカペンタエン酸等のようなポリプレニル系化合物を有効成分とする、肝細胞増殖もしくは肝再生を促進するための医薬を提供するものである。 本発明により提供される医薬は、正常肝細胞に対する選択的増殖作用を奏し得、よって例えば肝癌治療における肝再生等に有用である。
PCT/JP2008/001606 2007-06-21 2008-06-20 肝細胞増殖促進作用を有する医薬 WO2008155920A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1020107001174A KR101457737B1 (ko) 2007-06-21 2008-06-20 간세포 증식 촉진작용을 갖는 의약
EP08764189A EP2168577A4 (en) 2007-06-21 2008-06-20 MEDICAMENT HAVING THE EFFECT OF PROMOTING THE GROWTH OF HEPATOCYTES
CN200880021286.4A CN101720222B (zh) 2007-06-21 2008-06-20 具有促进肝细胞增殖作用的药物
US12/665,342 US20100184859A1 (en) 2007-06-21 2008-06-20 Medicament having promoting action on hepatocyte proliferation
JP2009520336A JP5352459B2 (ja) 2007-06-21 2008-06-20 肝細胞増殖促進作用を有する医薬
US13/464,432 US8455546B2 (en) 2007-06-21 2012-05-04 Medicament having promoting action on hepatocyte proliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-163355 2007-06-21
JP2007163355 2007-06-21

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/665,342 A-371-Of-International US20100184859A1 (en) 2007-06-21 2008-06-20 Medicament having promoting action on hepatocyte proliferation
US13/464,432 Division US8455546B2 (en) 2007-06-21 2012-05-04 Medicament having promoting action on hepatocyte proliferation

Publications (1)

Publication Number Publication Date
WO2008155920A1 true WO2008155920A1 (ja) 2008-12-24

Family

ID=40156084

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001606 WO2008155920A1 (ja) 2007-06-21 2008-06-20 肝細胞増殖促進作用を有する医薬

Country Status (6)

Country Link
US (2) US20100184859A1 (ja)
EP (1) EP2168577A4 (ja)
JP (1) JP5352459B2 (ja)
KR (1) KR101457737B1 (ja)
CN (1) CN101720222B (ja)
WO (1) WO2008155920A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019022222A1 (ja) 2017-07-28 2019-01-31 日産化学株式会社 培地添加用組成物及び培地添加用化合物並びにそれらを用いた細胞又は組織の培養方法
WO2020158841A1 (ja) 2019-01-30 2020-08-06 日産化学株式会社 ヒドラジド化合物及びキナーゼ阻害剤

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104174013B (zh) * 2014-08-16 2015-07-08 广州一品红制药有限公司 一种含促肝细胞生长素的组合物和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6332058B2 (ja) 1980-04-07 1988-06-28 Eisai Co Ltd
JPH05229940A (ja) 1992-02-26 1993-09-07 Ajinomoto Co Inc 肝再生促進剤
JPH0867628A (ja) 1994-06-23 1996-03-12 Chugai Pharmaceut Co Ltd 肝再生用治療剤
JP2003252792A (ja) 2002-03-04 2003-09-10 Inst Of Physical & Chemical Res 肝再生促進剤
JP2007023002A (ja) 2005-07-21 2007-02-01 Univ Of Tsukuba 肝再生促進剤
JP2007045721A (ja) 2005-08-08 2007-02-22 Univ Of Tsukuba 肝再生促進剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6332058A (ja) 1986-07-22 1988-02-10 株式会社　梅彦 石材の床張り方法
CN1073844C (zh) * 1994-06-23 2001-10-31 中外制药株式会社 肝脏再生的治疗剂
CA2407421C (en) * 2000-04-24 2009-11-03 Nikken Chemicals Co., Ltd. Activators of peroxisome proliferator-activated receptors
US6524610B2 (en) * 2001-02-26 2003-02-25 Julia Muszynska Nutritional composition made from conventional foods for mixing onsite in a blender and treating patients with hepatic disorders
WO2003097034A1 (fr) * 2002-05-17 2003-11-27 Nikken Chemicals Co., Ltd. Inhibiteurs de l'expression du tgf-$g(a)
ES2367802T3 (es) 2004-02-25 2011-11-08 The University Of Tokyo Medicamento capaz de inhibir la activación del factor de transcripción klf5.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6332058B2 (ja) 1980-04-07 1988-06-28 Eisai Co Ltd
JPH05229940A (ja) 1992-02-26 1993-09-07 Ajinomoto Co Inc 肝再生促進剤
JPH0867628A (ja) 1994-06-23 1996-03-12 Chugai Pharmaceut Co Ltd 肝再生用治療剤
JP2003252792A (ja) 2002-03-04 2003-09-10 Inst Of Physical & Chemical Res 肝再生促進剤
JP2007023002A (ja) 2005-07-21 2007-02-01 Univ Of Tsukuba 肝再生促進剤
JP2007045721A (ja) 2005-08-08 2007-02-22 Univ Of Tsukuba 肝再生促進剤

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
BIOHEM. BIOPHYS. RES. COMMUN., vol. 133, 1985, pages 1042 - 1050
BIOHEM. BIOPHYS. RES. COMMUN., vol. 219, 1996, pages 100 - 104
CELL, vol. 18, 1979, pages 153 - 163
EUR. J. PHARMACOL., vol. 510, 2005, pages 167 - 180
HIGGINS G.M. ET AL., ARCH. PATHOL., vol. 12, 1931, pages 186 - 202
J. CHEM. SOC. (C), 1966, pages 2154
J. LIPID RES., vol. 45, 2004, pages 1092 - 1103
KANZO, LIVER, JOURNAL OF THE JAPAN SOCIETY OF HEPATOLOGY, vol. 44, 2003, pages 383 - 394
KANZO, vol. 26, 1985, pages 605 - 612
MURATA K. ET AL.: "Polyprenoic acid ni yoru Kan Kagaku Hatsugan Yokusei no mechanism ni Kansuru Kenkyu", ACTA HEPATOLOGICA JAPONICA, vol. 26, no. 5, 1985, pages 605 - 612, XP008123813 *
N. ENG. J. MED., vol. 334, 1996, pages 1561 - 1567
OKUNO M. ET AL.: "INHIBITORY EFFECT OF ACYCLIC RETINOID (POLYPRENOIC ACID) ON THE SECRETION OF ALPHA-FETOPROTEIN IN CCL4-TREATED RATS", J. NUT. SCI. VITAMINOL., vol. 36, no. 5, 1990, pages 437 - 446, XP008123559 *
PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 1558 - 1562
See also references of EP2168577A4 *
SEGLEN ET AL., METHODS. CELL BIOL., vol. 13, 1975, pages 29 - 83

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019022222A1 (ja) 2017-07-28 2019-01-31 日産化学株式会社 培地添加用組成物及び培地添加用化合物並びにそれらを用いた細胞又は組織の培養方法
WO2020158841A1 (ja) 2019-01-30 2020-08-06 日産化学株式会社 ヒドラジド化合物及びキナーゼ阻害剤

Also Published As

Publication number Publication date
EP2168577A4 (en) 2010-10-27
KR101457737B1 (ko) 2014-11-03
US8455546B2 (en) 2013-06-04
US20120220659A1 (en) 2012-08-30
EP2168577A1 (en) 2010-03-31
JP5352459B2 (ja) 2013-11-27
JPWO2008155920A1 (ja) 2010-08-26
US20100184859A1 (en) 2010-07-22
CN101720222A (zh) 2010-06-02
KR20100040725A (ko) 2010-04-20
CN101720222B (zh) 2016-09-07

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