WO2008126363A1 - 脂肪肝又は非アルコール性脂肪性肝炎の予防及び／又は治療のための医薬 - Google Patents

脂肪肝又は非アルコール性脂肪性肝炎の予防及び／又は治療のための医薬 Download PDF

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Publication number
WO2008126363A1
WO2008126363A1 PCT/JP2008/000760 JP2008000760W WO2008126363A1 WO 2008126363 A1 WO2008126363 A1 WO 2008126363A1 JP 2008000760 W JP2008000760 W JP 2008000760W WO 2008126363 A1 WO2008126363 A1 WO 2008126363A1
Authority
WO
WIPO (PCT)
Prior art keywords
fatty liver
drug
preventing
treating
liver disease
Prior art date
Application number
PCT/JP2008/000760
Other languages
English (en)
French (fr)
Inventor
Yuji Yoshikawa
Megumi Yamamoto
Naoto Ishibashi
Mami Seki
Original Assignee
Kowa Company, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Company, Ltd. filed Critical Kowa Company, Ltd.
Priority to EP08720639.7A priority Critical patent/EP2143430B1/en
Priority to JP2009508889A priority patent/JP5341749B2/ja
Priority to CN200880011149.2A priority patent/CN101652134B/zh
Priority to ES08720639.7T priority patent/ES2555782T3/es
Priority to KR1020097022514A priority patent/KR101461252B1/ko
Priority to US12/593,053 priority patent/US20100120914A1/en
Publication of WO2008126363A1 publication Critical patent/WO2008126363A1/ja
Priority to HK10104346.1A priority patent/HK1138200A1/xx
Priority to US13/524,134 priority patent/US8673976B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　副作用の少ない脂肪肝又は非アルコール性脂肪性肝炎の予防及び／又は治療のための医薬であって、ポリプレニル系化合物（たとえば3,7,11,15-テトラメチル-2,4,6,10,14-ヘキサデカペンタエン酸）を有効成分として含む医薬。
PCT/JP2008/000760 2007-03-30 2008-03-27 脂肪肝又は非アルコール性脂肪性肝炎の予防及び／又は治療のための医薬 WO2008126363A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP08720639.7A EP2143430B1 (en) 2007-03-30 2008-03-27 Drug for preventing and/or treating fatty liver or nonalcoholic fatty liver disease
JP2009508889A JP5341749B2 (ja) 2007-03-30 2008-03-27 脂肪肝又は非アルコール性脂肪性肝炎の予防及び／又は治療のための医薬
CN200880011149.2A CN101652134B (zh) 2007-03-30 2008-03-27 用于预防和/或治疗脂肪肝或非酒精性脂肪性肝炎的药物
ES08720639.7T ES2555782T3 (es) 2007-03-30 2008-03-27 Fármaco para prevenir y/o tratar hígado graso o esteatosis hepática no alcohólica
KR1020097022514A KR101461252B1 (ko) 2007-03-30 2008-03-27 지방간 또는 비알코올성 지방성 간염의 예방 및/또는 치료를 위한 의약
US12/593,053 US20100120914A1 (en) 2007-03-30 2008-03-27 Medicament for prophylactic and/or therapeutic treatment of hepatic steatosis or non-alcoholic steatohepatitis
HK10104346.1A HK1138200A1 (en) 2007-03-30 2010-05-03 Drug for preventing and or treating fatty liver or nonalcoholic fatty liver disease
US13/524,134 US8673976B2 (en) 2007-03-30 2012-06-15 Medicament for prophylactic and/or therapeutic treatment of hepatic steatosis or non-alcoholic steatohepatitis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007090114 2007-03-30
JP2007-090114 2007-03-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/593,053 A-371-Of-International US20100120914A1 (en) 2007-03-30 2008-03-27 Medicament for prophylactic and/or therapeutic treatment of hepatic steatosis or non-alcoholic steatohepatitis
US13/524,134 Division US8673976B2 (en) 2007-03-30 2012-06-15 Medicament for prophylactic and/or therapeutic treatment of hepatic steatosis or non-alcoholic steatohepatitis

Publications (1)

Publication Number Publication Date
WO2008126363A1 true WO2008126363A1 (ja) 2008-10-23

Family

ID=39863523

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000760 WO2008126363A1 (ja) 2007-03-30 2008-03-27 脂肪肝又は非アルコール性脂肪性肝炎の予防及び／又は治療のための医薬

Country Status (8)

Country Link
US (2) US20100120914A1 (ja)
EP (1) EP2143430B1 (ja)
JP (2) JP5341749B2 (ja)
KR (1) KR101461252B1 (ja)
CN (1) CN101652134B (ja)
ES (1) ES2555782T3 (ja)
HK (1) HK1138200A1 (ja)
WO (1) WO2008126363A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011219439A (ja) * 2010-04-14 2011-11-04 Tottori Univ レチノイン酸受容体リガンドによるインスリン抵抗性改善作用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5304939B1 (ja) * 2012-05-31 2013-10-02 大日本印刷株式会社 光学積層体、偏光板、偏光板の製造方法、画像表示装置、画像表示装置の製造方法及び画像表示装置の視認性改善方法
GB201301626D0 (en) * 2013-01-30 2013-03-13 Dignity Sciences Ltd Composition comprising 15-OHEPA and methods of using the same
EP2808031A1 (en) * 2013-05-30 2014-12-03 Fundació Hospital Universitari Vall d' Hebron - Institut de Recerca Sex hormone-binding globulin for use as a medicament

Citations (10)

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JPS6332058A (ja) 1986-07-22 1988-02-10 株式会社　梅彦 石材の床張り方法
JPS6334855B2 (ja) 1980-12-24 1988-07-12 Eisai Co Ltd
JPH04290821A (ja) * 1990-12-07 1992-10-15 Efamol Ltd 液体栄養副作用の予防方法またはそれに用いる薬剤の製造方法
JPH09194362A (ja) * 1996-01-19 1997-07-29 Bizen Kasei Kk ドコサヘキサエン酸及びエイコサペンタエン酸含有リン脂質を含む組成物
WO2001080854A1 (fr) * 2000-04-24 2001-11-01 Nikken Chemicals Co., Ltd. Activateurs destines au recepteur active par le proliferateur de peroxisomes
JP2002104965A (ja) * 2000-09-27 2002-04-10 Kanegafuchi Chem Ind Co Ltd 脂肪肝予防・改善機能を有する組成物
WO2003097034A1 (fr) * 2002-05-17 2003-11-27 Nikken Chemicals Co., Ltd. Inhibiteurs de l'expression du tgf-$g(a)
WO2005079783A1 (ja) * 2004-02-25 2005-09-01 The University Of Tokyo 転写因子klf5の活性化抑制作用を有する医薬
JP2006232711A (ja) * 2005-02-24 2006-09-07 Tohoku Univ 血中中性脂肪低下作用および肝臓中性脂肪合成抑制作用および血小板凝集抑制作用を有する油脂
JP2007314492A (ja) * 2006-05-29 2007-12-06 National Agriculture & Food Research Organization 脂質代謝改善用組成物

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Publication number Priority date Publication date Assignee Title
JPS56140949A (en) * 1980-04-07 1981-11-04 Eisai Co Ltd 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenic acid
US5922345A (en) * 1990-12-07 1999-07-13 Scotia Holdings Plc Nutrition
JP2004290821A (ja) 2003-03-27 2004-10-21 Aichi Electric Co Ltd 混合装置
JP2008150307A (ja) * 2006-12-15 2008-07-03 Kenko Tsusho Kk 体脂肪の蓄積に起因する疾患の治療剤

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6334855B2 (ja) 1980-12-24 1988-07-12 Eisai Co Ltd
JPS6332058A (ja) 1986-07-22 1988-02-10 株式会社　梅彦 石材の床張り方法
JPH04290821A (ja) * 1990-12-07 1992-10-15 Efamol Ltd 液体栄養副作用の予防方法またはそれに用いる薬剤の製造方法
JPH09194362A (ja) * 1996-01-19 1997-07-29 Bizen Kasei Kk ドコサヘキサエン酸及びエイコサペンタエン酸含有リン脂質を含む組成物
WO2001080854A1 (fr) * 2000-04-24 2001-11-01 Nikken Chemicals Co., Ltd. Activateurs destines au recepteur active par le proliferateur de peroxisomes
JP2002104965A (ja) * 2000-09-27 2002-04-10 Kanegafuchi Chem Ind Co Ltd 脂肪肝予防・改善機能を有する組成物
WO2003097034A1 (fr) * 2002-05-17 2003-11-27 Nikken Chemicals Co., Ltd. Inhibiteurs de l'expression du tgf-$g(a)
WO2005079783A1 (ja) * 2004-02-25 2005-09-01 The University Of Tokyo 転写因子klf5の活性化抑制作用を有する医薬
JP2006232711A (ja) * 2005-02-24 2006-09-07 Tohoku Univ 血中中性脂肪低下作用および肝臓中性脂肪合成抑制作用および血小板凝集抑制作用を有する油脂
JP2007314492A (ja) * 2006-05-29 2007-12-06 National Agriculture & Food Research Organization 脂質代謝改善用組成物

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ATHEROSCLEROSIS, vol. 92, 1992, pages 31 - 40
FACTOR V.M. ET AL.: "Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis", J. BIOL. CHEM., vol. 273, no. 25, 1998, pages 15846 - 15853, XP008117968 *
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GASTROENTEROLOGY, vol. 116, 1999, pages 1413 - 1419
J. CHEM. SOC., 1966, pages 2154
MUTO Y. ET AL.: "Prevention of second primary tumors by an acyclic retinoid polyprenoic acid, in patients with hepatocellular carcinoma", N. ENGL. J. MED., vol. 334, no. 24, 1996, pages 1561 - 1567, XP000884177 *
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N. ENGL. J. MED., vol. 313, 1985, pages 981 - 985
See also references of EP2143430A4 *
TAKEDA N. ET AL.: "KLF5 inhibitor Am80 reduces atherosclerosis, adipose tissue growth, and fatty liver disease", CIRCULATION, vol. 110, no. 17, 2004, pages 786, XP008117960 *
TANAKA T. ET AL.: "Shibokan ni Okeru PPARs no Rinshoteki Igi", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 63, no. 4, 2005, pages 700 - 706, XP008118063 *
TOXICOLOGY, vol. 30, 1984, pages 115 - 124

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011219439A (ja) * 2010-04-14 2011-11-04 Tottori Univ レチノイン酸受容体リガンドによるインスリン抵抗性改善作用

Also Published As

Publication number Publication date
JP5341749B2 (ja) 2013-11-13
ES2555782T3 (es) 2016-01-08
KR20100015986A (ko) 2010-02-12
JP2013216679A (ja) 2013-10-24
US20120259015A1 (en) 2012-10-11
CN101652134A (zh) 2010-02-17
EP2143430A1 (en) 2010-01-13
EP2143430B1 (en) 2015-09-23
US8673976B2 (en) 2014-03-18
KR101461252B1 (ko) 2014-11-12
EP2143430A4 (en) 2010-12-29
HK1138200A1 (en) 2010-08-20
CN101652134B (zh) 2015-07-15
JPWO2008126363A1 (ja) 2010-07-22
US20100120914A1 (en) 2010-05-13

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