WO2008135011A2 - Revêtement et gaine - Google Patents

Revêtement et gaine Download PDF

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Publication number
WO2008135011A2
WO2008135011A2 PCT/DE2008/000686 DE2008000686W WO2008135011A2 WO 2008135011 A2 WO2008135011 A2 WO 2008135011A2 DE 2008000686 W DE2008000686 W DE 2008000686W WO 2008135011 A2 WO2008135011 A2 WO 2008135011A2
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
hydro
ultrasound
casing
edition
Prior art date
Application number
PCT/DE2008/000686
Other languages
German (de)
English (en)
Other versions
WO2008135011A3 (fr
WO2008135011A4 (fr
Inventor
Robert Simmoteit
Detlef Gorski
Manfred Helbig
Original Assignee
3Mach Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3Mach Gmbh filed Critical 3Mach Gmbh
Priority to EP08748764A priority Critical patent/EP2142255A2/fr
Priority to DE112008001856T priority patent/DE112008001856A5/de
Publication of WO2008135011A2 publication Critical patent/WO2008135011A2/fr
Publication of WO2008135011A3 publication Critical patent/WO2008135011A3/fr
Publication of WO2008135011A4 publication Critical patent/WO2008135011A4/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
    • A61B8/4236—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames characterised by adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
    • A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue

Definitions

  • the present invention relates to a support, casing or sheath and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, and their use Phys, or ath and their use Phys, or Phys, etc.
  • the invention finds application in cosmetic, medical, pharmaceutical and technical processes, preferably in the medical and cosmetic treatment of outer tissue layers.
  • the skin is responsible for the regulation of the water balance and serves as a barrier and protective layer against external influences.
  • a number of medical procedures have been developed. These methods are used to kill cancer cells, to stimulate tissue cells or to increase the penetration of drugs.
  • Other methods use sound sources to stimulate internal healing processes or for tissue analysis.
  • Such a method and device is described in DE 692 146 72 T2 for the emission of sound waves.
  • thermal effects and gravitational effects are generated in the tissue.
  • EP 1364 624 A1 uses a gel pad made of polyacylamides in order to improve the laser treatment.
  • energy is supplied to the biological tissue via the skin in the form of electromagnetic fields, light, ionizing radiation or ultrasound waves. Difficulties always occur when the protective layer of the skin has already been damaged or allergic reactions occur.
  • ultrasound medicaments can be incorporated in creams into deeper tissue regions.
  • the method is called ultrasonophoresis. Basically, due to the sound vibrations, especially at higher dosage and a continuous application, there is a warming especially at the boundary layers. This temperature increase of about 40 - 45 0 C improves the extensibility of the collagen tissue (scars, tendons, ligaments).
  • the object of the invention relates primarily to a support and casing or a Ummante- ment for the transmission of sound waves and secondarily also a mass transfer in conjunction with high-energy radiation or sound waves. Furthermore, the invention makes it possible to further develop existing therapeutic and diagnostic methods and improves or expands the possibilities for using these methods.
  • the reprocessing of the pads or casings makes an economical and material-saving use possible.
  • the pads, sheaths and sheaths are used in combination with medical devices and after medical and technical treatment procedures.
  • the use of a hydro tissue in the area of medical irradiation and ultrasound methods, the introduction of pharmaceutical substances and the cosmetic treatment make them safer for humans and additionally permit a transfer of the substance before and after the treatment.
  • a substance transfer and mass transfer via the skin may be assisted, for example with the aim of see how to activate regeneration processes of the skin and internal tissues.
  • the invention can be used particularly advantageously in the field of ultrasound diagnostics and ultrasound treatment, since the invention expands the use of this technology and, in so doing, the economic use and hygiene of the treatment is improved.
  • a support, casing and sheath in the field of medical, pharmaceutical, cosmetic and technical applications, characterized in that it consists of a hydro tissue made of bacterial cellulose fibers or of a fiber composite material and with a water or aqueous solution fraction of the hydro tissue forming at least one own aqueous film or a thin aqueous layer on or between material surfaces for coupling sound waves and in conjunction with the remaining solution fraction in the hydro tissue provides a transmission medium for sound waves or decelerates radiation, scatters or filters out.
  • the pads and sheaths are defined as a sheet-like or shaped or tubular material layer which can be used in combination with a probe, a catheter, a holder, a medical component or alone.
  • the mobile water fraction is meant an extrudable contiguous aqueous portion which can be extruded and / or mechanically agitated from the fine mesh fine fiber network of bacterial cellulose fibers or a composite of these fibers with microfibers or gel bodies of another fabric.
  • the material referred to as Hydrogewebe is defined as fibrous material or substance that is technically or biologically produced and contains a high aqueous content. This also includes fleece-like materials. Fiber composite material, do not consist of a material compound fibrous materials or may also contain several different fibrous materials.
  • straight bacterial cellulose nonwoven webs form a coherent water layer and film of water, which are particularly well suited to the transmission of sound waves and scattering, and to water film
  • Filtering of rays are suitable.
  • a water film of a few ⁇ m up to the nm range forms by itself. This film is in contact with the inner water layer and thus represents a suitable medium for the coupling of sound waves and the scattering and filtering of radiation.
  • the invention can be applied in the form of a dressing or a wrapper to all bacterial celluloses.
  • An advantage is z. B., if a mobile water content or liquid content of at least 60 wt.% Is present.
  • the formation of its own ever rebuilding water film improves the coupling of ultrasound.
  • This property of the hydro tissue has the advantage over known gel pads or gels that the ultrasonic probe slides particularly well on the overlay or in conjunction with a sleeve, without losing the coupling contact. In this case, no high contact pressure is required from above. Accordingly, this applies if the hydro tissue completely or only partially covers or envelops the ultrasound probe.
  • a coherent water layer of thicknesses of z. B. 2 - 10 mm in the hydro tissue forms a suitable forward and scattering distance or a filter section for high-energy radiation or a coupling medium for sound waves.
  • Greater thicknesses of up to 20 mm and more are more suitable for the therapeutic application of high-energy radiation or for targeted coupling of highly focused ultrasound (FUS).
  • the hydro tissue has a tissue content of bacterial cellulose fibers between 60-100%.
  • tissue content of bacterial cellulose fibers between 60-100%.
  • a conventional sponge does not have these properties but has partitions or parting surfaces.
  • the proportion by weight of water or of aqueous solution in the bacterial cellulose can be up to 99% and is held firmly in the first place by physical forces and / or by hydrogen bonds, without dripping from the fabric by itself.
  • bacterial cellulose with a smooth surface in the nm range and a continuous cross-linked structure is particularly well suited for ultrasound transmission on uneven surfaces, because the bacterial cellulose sucks on a biological surface without technical assistance and forms a contact layer.
  • the use is more hygienic compared to known ultrasound gels.
  • the water or the liquid contained in the bacterial cellulose is not bound as in a gel.
  • the layer or envelope made of bacterial cellulose with layer thicknesses of 0.2 - 20 mm behaves like a stable layer of water, without which it can flow apart. This water layer serves as a kind of preliminary route for rays and waves for transmission to the skin, tissue or other material.
  • a bacterial cellulose with a high water content of over 70% by weight with a smooth surface not only allows the formation of a separate water film for ultrasonic coupling, but also an effective, rapid evaporation and thus a mass transfer with the environment.
  • gels or highly cross-linked hydrogel overlays do not have these properties.
  • Our observations prove, however, that it is precisely this water mobility in the bacterial cellulose tissue, which consists of the finest fiber networks, not only provides advantages for the coupling of ultrasound, but also changed the effect of high-energy rays meaningful.
  • the preferred bacterial cellulose has a DPw value between 4000 to 9000 (degree of polymerization), wherein the synthesis direction preferably proceeds in the plane.
  • the soft surface with a surface roughness in the nm range allows the smallest unevenness to be imaged by another surface.
  • the material may contain alcoholic or other antiseptic solutions. Since the material forms a sterile barrier, it is possible to apply the ultrasound over a wound area or via an internal organ. It is particularly advantageous that such conditions can be used to cover the surgical field or as organ covers. In this case, the surgical field can be observed with ultrasound diagnostics via the support in the immediate vicinity and without gel.
  • the ultrasonic probe can sit flat, although the substrate deformations, z. B. elevations or depressions possesses.
  • the sound signal is thus forwarded particularly well compared to gel.
  • What is important for the ultrasound, z. As a smooth flat surface on uneven ground, is also important for the introduction of high-energy radiation.
  • the treatment procedure in deeper tissue regions can thus be optimally adjusted and standardized.
  • the hydro tissue or hydro tissue according to the invention find similar materials with the property that these fluids can precipitate, preferably in ultrasound diagnostics (echo pulse method) or in ultrasound treatment such that an ultrasound head is connected here is used with a support or a wrapper or enclosure for coupling ultrasound.
  • the ultrasound heads can be placed without gel on the hydro tissue and through the soft, moist and smooth surface, the sound is transmitted to the skin or a biological tissue.
  • the hydro fabric also forms on uneven surfaces and supports the application in that aqueous molecules can be transported in and out of the material and thus a close contact without air entrapment with biological surfaces is produced.
  • a defined ultrasound transmission layer thickness can be produced from hydro tissue despite the movement of the ultrasound head, which is advantageous in the echo-pulse method.
  • the hydro tissue may be changeably connected to a holder with an ultrasound probe.
  • other materials exude the liquid and have only a small proportion of solids, such.
  • soft and pore-containing substances that can store liquid and are suitable for the transmission of ultrasound.
  • Collagenous tissue or hydratable cellulosic sheets of native cellulose are such substances.
  • silicones ie plastics with similar properties.
  • the overlay in an infrared light treatment behaves like a water filter.
  • the bacterial cellulose is on the skin to be irradiated.
  • some of the damaging radiation is filtered out, at the same time the relevant tissue areas are cooled and even a temperature-driven mass transfer is made possible.
  • the inventive requirement can also be used in the field of radiological radiotherapy (eg gamma irradiation) for generating stray radiation and used to combat skin cancer. Stray radiation is actually undesirable in deeper tissue.
  • the material could be usefully used in intensity modulated radiation therapy (IMRT).
  • IMRT intensity modulated radiation therapy
  • the ionizing radiation can be adjusted at the site of action and beyond substances are additionally exchanged with the environment or with the tissue.
  • the hydraulic material is also used in the field of wet wound care.
  • the special properties of the cooling coupled with a mass transfer allows that z.
  • the hydro tissue replaces the usual ultrasound gel as a coupling medium or a transfer medium as a cover or as a support for ultrasound probes.
  • the advantage is that the material as a protective cover in the form of a hollow body or as a kind of protective cap envelops the probe and flexes even on uneven surfaces and sucks, thereby additionally displace the air between the interfaces. The fact that wet contact surfaces or a liquid film is present, the sound can be optimally transmitted.
  • this protective cover it is possible that the ultrasound probe in inaccessible places in the body, such. B. in the vagina, can be introduced. Another area of application is the eyeball.
  • a support from the hydro tissue is used.
  • the material can wrap extremities such as fingers or toes entirely or only in the front part in order to protect them or treat them safely. This also applies to other parts of the body.
  • Application of high-frequency probes (up to 50 MHz), but also pulsed frequencies of different areas can be combined with the hydro tissue.
  • the tissue or the skin is protected from excessive energy input.
  • the high solution and water content which in a suitable case is more than 90% by weight in the hydro tissue, is a prerequisite for enabling said functions in combination with ionizing radiation, laser light or sound waves during or after the treatment of a biological material.
  • the support or the casing may contain bacterial cellulose solutions with or without active ingredients and be provided in the further embodiment of the invention, a transfer of these drugs through the skin.
  • the material supports in conjunction with energetic rays or sound waves preferably a temperature-driven mass transfer with a biological tissue see. This is done by an increase in the evaporation of substances, which is caused by the fact that energy is or was supplied from the outside.
  • bacterial cellulose enables a hydrobalance, a substance transfer and a purification of the biological tissue during, but also after the treatment with energetic rays or sound waves.
  • This can be done in such a way that substances and germs from the upper regions of an adjacent biological surface, such as the z.
  • the invention thereby supports the cellular balance in such a way that tissue regeneration is naturally promoted in conjunction with a solution exchange. This in turn has an influence on fibroblast activation as well as on other cellular processes.
  • the dandruff and - - A skin pigmentation for example, after radiotherapy, is reduced by the inventive edition. The formation of a Radidermatitis is thus reduced in the area of irradiated skin areas.
  • the field of application is not limited to intact skin.
  • the material may also be used in wounds or biological tissues in conjunction with additional radiation or sonication therapy. In doing so, the energetic radiation or the sound waves in the overlay or in the shell itself will also generate heat.
  • the heat development in the overlay and over the biological tissue is used as an additional driving force for the mass transfer.
  • This compatible effect shortens the mass transfer times and improves the acceptance in the application and economic use.
  • a further advantage is that high-energy infrared or ionizing radiation, laser light or ultrasound waves damage the skin and the inner tissues to a lesser extent due to the high protective content of the water in the overlay. In addition, less heat in the biological tissue and temperatures above 45 0 C are very largely avoided.
  • the bacterial cellulose hydrous tissue can be sterilized and purified in water vapor or by another method.
  • the type of cleaning can be done by washing, but also by suitable solvents and cleaning agents.
  • a specially designed cleaning and storage device with a spray nozzle can be used. Since there are currently no suitable and specific ultrasonic probe cleaning devices, this device can also wash out the commercial gel.
  • the bacterial cellulose used is stable against alcoholic solutions, but also against alkalis. Thus, appropriate cleaning agents can be used to ensure hygiene.
  • hydro tissue is also formed or connected as a sponge, nonwoven or gel pad or partially or completely encased.
  • Envelopes or additional coverings may be latices, silicones, polyurethanes, and other films or shells, with or without pores, that allow water molecules to pass outward to allow for a water film.
  • a bacterial cellulose hydrocloth or in combination with a plastic material or a combination of these materials in the form of a gel-like film, woven or nonwoven fabric or a sponge-like structure.
  • a plastic material or a combination of these materials in the form of a gel-like film, woven or nonwoven fabric or a sponge-like structure.
  • bacterial celluloses suitable that have no thin and delimited layer structure similar to a puff pastry or as the pages in a book.
  • a uniform and consistently high material layer with thicknesses between 0.2 - 20 mm transmits the sound better than a non-uniform structure. It is not important how the bacterial cellulose is made, but only important that this cellulose produces its own liquid or water film.
  • a uniformly structured and synthetically produced bacterial cellulose having a surface roughness between 10 - 500 nm and a more than 60% by weight ofWhenpressbarem water or a liquid is preferred to z. B. to allow a 1 - 200 microns thick water layer or a water film.
  • the bacterial cellulose has an average degree of polymerization with a DPw value between 4000-9000.
  • This bacterial cellulose may contain other components or fillers which are firmly crosslinked with the cellulose and / or only stored. This is necessary if the material is to be freeze-dried or if the hydro fabric must meet certain mechanical requirements. The freeze-dried bacterial cellulose must be soaked with a solution adapted to the application before use.
  • the contained water or liquid is physically mobile and may, for example, evaporate. Due to the evaporation effect and the low surface roughness in the nm range a direct contact with the adjacent surface is created. Flat contact improves and increases the exchange of matter with a biological surface. It has also been found that the preferred bacterially synthesized cellulose can also contain small quantities of plastic fibers with thicknesses in the ⁇ m range in small quantities. A mixed tissue of foreign fibers and biological fibers is created by the biological activity of Acetobacter Xylinum bacteria, which weave the foreign fibers with bacterial cellulose. In the interstices of the network, water and solution molecules are preferably connected by hydrogen bonding and OH groups on the cellulose threads.
  • a pure and native bacterial cellulose or a mixed material with other hydrogels, such as Kollidon or other substances, such as. As hyaluronic acid can be used.
  • the known manufacturing process ensures that the bacterial cellulose has a mean degree of polymerisation (DPw value) of at least 4000.
  • DPw value mean degree of polymerisation
  • 0.1-10% of PVA, CMC or MC or other additives in the form of hydrogels may be added to the nutrient medium.
  • Bacterial cellulose in the form of pads or shells are inoculated by known manufacturing processes with cellulose-forming bacteria, for example with a dimensionally stable cellulosic layer producing strain of the microorganism Acetobacter Xylinum and cultured at a temperature of about 28 0 C (see preparation WO01061026, DE 100 2275C2).
  • the nutrient solution contains in a known manner D-glucose, disodium hydrogen phosphate, citric acid and standard extracts.
  • the stability and internal structure of the bacterial cellulose can be improved in the production by additional additions of water-soluble polymers or tissue fibers or nets. These additives can z.
  • polyvinyl alcohol PVA
  • carboxymethyl cellulose CMC
  • methyl cellulose MC
  • additives are added in concentration between 0.1-10% to the culture medium.
  • the total water content of a suitable hydro tissue is between 80-99% by weight and may, however, be 70% by weight with additives or by removal of water, the extrudable fraction being at least 60%. Due to the fabric-like structure, the bacterial cellulose, especially at thicknesses below 5 mm, has good semitransparent properties. At thicknesses above 10 mm, the hydro tissue is no longer transparent.
  • a matrix, impression or a shaped substrate or base was introduced into the production container, it was observed that the bacteria reproduce this shaped substrate. This results in an edition but also shell with different thicknesses or with a suitable impression for resting on the eyes, noses, extremities, breast and Po Scheme or other shaped areas of the human body.
  • the construction of the pads, sheaths and / or sheath may be designed such that a perforated foil or a film with visible pores for the expansion of the usability of the material is introduced during the manufacturing process.
  • the connection is not made by sewing, but by depositing the film on an existing cellulose layer. Subsequently, the structure is wetted with inoculated nutrient solution and the process of wetting repeated.
  • the bacterial cellulose may have holes to connect to an ultrasound probe or in conjunction with a holder therewith.
  • a device in the form that a Velcro strip is sewn with a bacterial cellulose. With this device, the material can completely or partially envelop a probe tip.
  • the appropriate hydro-tissue pad has high ductility and flexibility and can be used on uneven areas of the skin such as the knee, face or shoulder. -LO area, rest.
  • the pads offer good overall properties for the application z. B. in the form of a plaster, as a wound dressing, as an envelope or as Päd.
  • the strength and structure of the hydro tissue has the advantage that the pads or sheaths from the hydro tissue can be treated by simple cleaning and / or sterilization.
  • a simple cleaning is done in the form that the used material is cleaned in boiling water.
  • the procedure is as follows: used Hydroauflagen be introduced into a vessel with a lid and doused with sufficient boiling water. Subsequently, salt or a salt mixture is added to a physiological saline solution, eg. B. Ringer or saline solution to produce.
  • a physiological saline solution eg. B. Ringer or saline solution to produce.
  • the hydro tissue is placed in a physiological solution and the solution is boiled by a microwave oven. After cooling, the hydro tissue is as good as sterile and can be used.
  • Advantageous are cleaning process in which z. For example, a spray jet is also used for cleaning in order to remove particle deposits on the material.
  • the cleaning can also be done automatically with a cleaning device having a spray nozzle in the bottom. This may be useful if the material is used in conjunction with an ultrasound probe or ultrasound probe and should not be removed from this probe in every application.
  • the device serves as a storage device in order to keep the bacterial cellulose moist.
  • the cleaning or storage solution contained here is boiled in the device by means of heating rods in order to achieve a sterilization.
  • a device for cleaning ultrasound probes improves the hygiene in the field of UI rapid diagnosis altogether even without the connection with hydromaterials. In this case, the device can be used alone, but also in conjunction with an ultrasound device application.
  • the overlay or wrapper may be used as follows: a) The overlay is placed or preceded in the first step as a protective, barrier or transfer layer on a biological tissue surface. In this case, z. As infrared rays or ultrasonic waves on this layer of material and are transmitted to the biological tissue surface. The radiation is filtered by the water content and substance content and sound waves forwarded. She was- Ine mental or the sound entry is thus not directly on the tissue surface. Tissue damage is avoided. After treatment, the material remains on the fabric for a certain time and continues to exchange fabrics with the adjacent surface.
  • a bacterial cellulose pad or bacterial cellulose pad or sheath is mechanically releasably bonded directly to the probe head via, for example, a fixation device.
  • the probe thus prepared is placed on the skin of a patient or passed over the skin and thus carried out an ultrasound diagnosis or treatment.
  • Embodiments of the dressings, sheaths, wraps and / or caps made of bacterial cellulose result from the applications. These may include the following embodiments:
  • bacterial cellulose or the inventive hydro tissue is suitable for the following fields of application:
  • the hydro tissue contains an alcoholic or antibacterial solution and is applied as a contact surface on the skin in order to enable image diagnostics.
  • a rod-shaped ultrasound probe is covered with a cap made of hydro tissue.
  • this cap is additionally slipped over with a latex tube and introduced, for example, in the vaginal opening. The advantage is that no contamination or contamination on the ultrasound probe occurs and the cleaning of the probe from the gel is unnecessary. Alternatively, the latex tube is omitted if the product is to be used as a disposable product and / or sterile.
  • an embodiment in which the bacterial cellulose or the hydro tissue surrounds or envelopes an ultrasound probe in the front area is also preferred.
  • a flat strip which is also available as a support for a wrapper
  • this z. B. sewn with a Velcro or otherwise connected Since the material is sewable, z. B. the material and the Velcro strip with a sewing thread or alternatively a clip connected.
  • This device allows the flexible fixation of the material with an ultrasound probe.
  • a molded Kunststoffhalte- tion or a molded part with a clamping zone connect the material mechanically releasable. Most simply, this task can also take over a ring, a clamping spring or fixing collar.
  • a practical application of the invention is the treatment of body regions with infrared light.
  • flat pads with a thickness between z. B. 1 - 6 mm placed on the skin and irradiated at a defined distance with a conventional infrared source.
  • larger thicknesses are used.
  • the high-energy infrared light impinges on the Hydrogewebeauflage and generates an elevated temperature here.
  • the safe part of light is filtered out by the containing water.
  • the skin does not suffer from skin damage due to the cooling effect of the overlay.
  • the increase in temperature in the irradiated area allows a faster absorption of substances from the upper layers of the skin and thus leads to purification.
  • the hydro tissue may contain substances such as hyaluronic acid, soluble collagen, pharmaceutical or cosmetic active ingredients, tannin, vitamins, vegetable extracts, oils etc. or other cosmetically relevant active ingredients with or without disinfectants and / or cleaning solutions or by Inkuba - tion with a solution containing these substances are introduced.
  • Bacterial cellulose dressings are used here for the treatment of scar tissue or after peeling of the skin in combination with laser or ultrasound probes. The aim is to introduce cosmetic substances, water and / or physiological solutions into the upper layers of the skin. This may be useful if an injection with hyaluronic acid has previously taken place.
  • the invention can be applied to all fields of life as well as to commercial or industrial applications where a protective, cooling and transfer pad or sheath with an exchange of substances, liquids, media or particles is desired. In particular, wherever it is necessary to ensure an economical cosmetic and medical treatment.
  • Fig. 1 Use and function of the invention in the ultrasonic diagnosis or treatment as a support or shell in contact with a surface.
  • Fig. 2a formation of a water film in conjunction with an ultrasonic head.
  • Fig. 2b Support for producing a flat surface on an uneven surface.
  • Fig. 3 Use and function of the invention in the infrared treatment of tissue.
  • Fig. 5 Use and function of the invention in examination in body cavities.
  • Fig. 6 Detailed view of a jacketed bag with a media supply.
  • Fig. 7 Device with a Velcro in conjunction with an ultrasound probe
  • FIG. 1 shows the use and function of the invention in ultrasound diagnosis or treatment as a support or sleeve in contact with a surface.
  • Figure A shows a hydro-tissue 1 or a hydro-layer, which rests on a surface 12 of a skin or a material 5.
  • a thin film of water (not shown) is formed. This film may also form between the surface 12 and the outer surface of the bacterial cellulose.
  • the outer surface 3 also allows evaporation of the water.
  • the hydro-tissue 1 can absorb substances (arrow d.) From the skin or optionally also offer substances for replacement.
  • the ultrasound probe 4 rests directly on the surface 3 of the support 1.
  • the ultrasound 9 is on the support 1, z.
  • the echo is shown, which takes its way back to the probe.
  • Figure B is an ultrasound probe 4, at least in the front part of a hydro-tissue sleeve 2 sheathed and z. B. fixed with a silicone ring 6 at this.
  • the pressure from above (arrow e) also produces a film of water between the surface 3 and the outer surface of the probe. The depressed water content, however, can not drain.
  • a sleeve 2 is also shown in section, which covers an ultrasonic head 4.
  • the ultrasound head is not directly on the hydro tissue, but inside the sleeve 2 is a space 8, in which a solution or a gel can be introduced.
  • This solution is used for sound transmission and the water film between the bacterial cellulose and the skin or material improves the sound transmission.
  • the sleeve 2 is fixed with a sleeve 7 so that the inner solution or the material can not escape.
  • the latter embodiment can preferably be used in material testing, but also for the introduction of active ingredients into the skin.
  • FIG. 2a shows the formation of a water film in conjunction with an ultrasound head. It is shown how by pressing from above (arrow e) additional water or aqueous medium (arrow g.) Is pushed out of a hydro tissue 1 or a hydro layer and accumulates between ultrasound head 4 and the surface 3 to a visible aqueous film 33.
  • the film 33 is only a few microns thick and the aqueous medium is forced by the pressure from top to outside 34. Although the thickness of the film is reduced, the contact with the inner movable liquid layer remains.
  • This layer 33 in the form of a glossy skin already forms by the weight of the material. In this layer thickness it is hardly visible on the surface of the material.
  • a water film also forms between a biological tissue and the overlay, but this film is affected by the evaporation through the hydrocloth. Furthermore, this creates a direct contact and exchange with the mobile medium in the support (arrow g.).
  • a permanent aqueous film can form between the lower side of the hydroentangle 1 and the surface 12.
  • evaporation (arrow f) liquid is discharged to the outside and this in turn sucks liquid (arrow d) z. B. from the skin 5 on. Due to the soft and deformable surface 3 of the hydro-tissue 1, the film continues to move with the movement of the ultrasound head, thus enabling optimum coupling for the ultrasound signal.
  • Fig. 2b shows a support for producing a flat surface on an uneven surface.
  • a support 1 which has a Ab- or molding 35. By this formation 35, the support optimally covers an uneven surface 12, z. B. from an uneven body region 5 in order to carry out a treatment here.
  • a tarp or planar outer surface 3 is made into an uneven surface.
  • an ultrathin liquid layer 33 which is particularly typical of thicker bacterial cellulose pads. Due to the flat surface with a soft deformable surface 3, the ultrasonic probe can lie smoothly without an air layer and the sound can be coupled in here.
  • the transmission 9 and reception signal 10 is optimally introduced.
  • the edition improves the use of the echo-pulse method.
  • a sheath may have ab- or formations.
  • Figure 3 shows the use and function of the invention in the infrared treatment of tissue.
  • a two-dimensional hydro-tissue support 1 On the skin 5 of a patient is a two-dimensional hydro-tissue support 1. About a spaced light source 14 ultra-bright light 11 of different intensity is emitted. The emitted light 11 is filtered by the support, which is in direct contact with the skin surface 12, and only the longer rippled light is transmitted. In the skin 5, the penetrated red light component generates a heating. This in turn drives the evaporation over the surface 3 (see arrow a.) and allows cooling, despite the energy supply to the skin.
  • a water film 33 can likewise form at the boundary layer 12, since the entry of the tissue water into the overlay 1 is also controlled by the evaporation and more liquid can be offered via the skin than is evaporated.
  • FIG. 4 shows the use and function of the invention in radiation treatment with ionizing radiation.
  • ionizing or electromagnetic radiation is emitted via an X-ray or other radiation source 15.
  • the radiation 13 penetrates via the surface 3 first in the hydro tissue 1 and generates a scattered radiation 16, which penetrates in a typical manner (arrows a) in the skin or in an adjacent tissue 5.
  • Due to the thickness of the flow path of the support 1 a suitable dose of action is introduced into the upper tissue region.
  • a suitable dose of action is introduced into the upper tissue region.
  • an aqueous film 33 can likewise form in the contact area skin / support.
  • FIG. 5 shows the use and function of the invention during examination in body cavities.
  • a rod-shaped ultrasound probe 4 is surrounded in the front region with a hydro tissue 2.
  • the material can completely envelop the insertable probe region 4.
  • the Hydrogewebehülle 2 is used for ultrasonic transmission into a body cavity 17.
  • a water film 33 is formed by mechanical pressure of the ultrasound probe. This is also possible because the tissue itself can give off fluid. If no additional casing for protection and only one sterile casing 2 made of bacterial cellulose is used, a mass transfer can also take place here.
  • the device may additionally be surrounded by a thin latex sheath which serves as protection against infections. This additional plastic sleeve can be discarded. Shown is the application of an echo-pulse method.
  • a therapeutic ultrasound for the treatment of the tissue can also be used here. Also conceivable would be the destruction of kidney stones.
  • the bacterial cellulose would serve as a transmission medium for shockwaves.
  • FIG. 6 shows a detailed representation of a jacketed bag with a media feed.
  • the sectional view shows a bag 18, which is covered by a hydro fabric 2.
  • the bag 18 is supplied via a hose 19 with solution.
  • the interior 8 of the bag 18 may also be impermeable to solutions.
  • radioactive rays 13, z. As technetium introduced. Due to the high aqueous content of the bacterial cellulose casing 2, a suitable scattered radiation 16 is made possible. The latter in turn can destroy cancer cells inside a body.
  • a catheter may be embedded or sheathed with the hydro tissue here. This device has the advantage that the inner patient tissue can be specifically irradiated.
  • FIG. 7 shows a device with a Velcro strip in conjunction with an ultrasound probe.
  • Figure A shows a device in which a hydro tissue 1 from a bacterial cellulose strip is sewn terminally with a hook and loop tape 37 via sewing threads 38.
  • a molded part can also clamp the hydro tissue at the terminal end.
  • This molded part is part of a holding or fixing device and can be connected to a suitable holding trough or holding counterpart on the ultrasonic head so as to fix the hydro-tissue to the ultrasonic head.
  • the Velcro 37 should allow the changeable fixation.
  • the hydro-fabric 1 may also have lateral elevations or an edge or have a shoe-like shape.
  • FIG. B With this device, a dargesteller in Figure B ultrasound head 4, wrapped or wrapped in the front.
  • This connection is shown in Figure C.
  • the Velcro strip 37 has created a detachable connection.
  • Figure D shows a detail in a side view. In side view, the flanks 41 of the front ultrasound head region 4 are enveloped by the bacterial cellulose 1.
  • the bacterial cellulose strip is changeably connected to the transducer 4.
  • liquid 39/8 will accumulate if the material 1 does not fit snugly against the lower region of the probe 4.
  • liquid 8/39 is displaced and liquid from the bacterial cellulose 1 is also distributed to the skin 12 by pressure from above.
  • a thin liquid film 33 forms, which ensures that the probe 4 slides over the skin surface 12 and the ultrasonic signal is coupled in.
  • the fact that the material 1 contains a lot of liquid it is ensured that enough liquid is supplied. Part of the liquid can also be deposited laterally.
  • an optimal form fit with the ultrasound probe would be given.
  • an additional fluid reservoir could be located here to provide fluid to the front transducer area.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Acoustics & Sound (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un revêtement, une gaine et une enveloppe en cellulose bactérienne, ainsi que l'utilisation de ces éléments. Dans le cadre d'une utilisation d'appareils médicaux qui émettent des rayonnements hautement énergétiques et des ondes sonores, cette invention permet de perfectionner des procédés thérapeutiques et diagnostiques déjà existants ou d'étendre les possibilités d'application de ces procédés. Cette invention peut s'appliquer à des procédés cosmétiques, médicaux, diagnostiques et pharmaceutiques. Les revêtements, gaines et enveloppes constitués d'une hydrocouche à fibres réticulées sont de préférence utilisés pendant et après des procédés de traitement médicaux et techniques et permettent de transférer des matières et de transmettre des rayonnements ou des ondes hautement énergétiques, tout en assurant une protection contre ces rayonnements hautement énergétiques ou ces ondes. Le fait de pouvoir réutiliser les revêtements, gaines et enveloppes, même dans la configuration d'un dispositif, permet une utilisation économique et économe en matière.
PCT/DE2008/000686 2007-05-03 2008-04-19 Revêtement et gaine WO2008135011A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08748764A EP2142255A2 (fr) 2007-05-03 2008-04-19 Revêtement et gaine
DE112008001856T DE112008001856A5 (de) 2007-05-03 2008-04-19 Auflage und Hülle

Applications Claiming Priority (2)

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DE200710020726 DE102007020726A1 (de) 2007-05-03 2007-05-03 Auflage und Hülle
DE102007020726.5 2007-05-03

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WO2008135011A2 true WO2008135011A2 (fr) 2008-11-13
WO2008135011A3 WO2008135011A3 (fr) 2009-03-05
WO2008135011A4 WO2008135011A4 (fr) 2009-04-30

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Cited By (4)

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JP2012176180A (ja) * 2011-02-28 2012-09-13 Takiron Co Ltd 超音波診断用探触子の装着用スペーサー
WO2014024286A1 (fr) * 2012-08-09 2014-02-13 タキロン株式会社 Écarteur pour montage d'une sonde de diagnostic à ultrasons
CN103654866A (zh) * 2013-11-18 2014-03-26 徐州广安医疗科技有限公司 一种腔内超声探头隔离套
CN109350121A (zh) * 2018-12-19 2019-02-19 邵军 一种自动超声探头无菌套头机

Families Citing this family (1)

* Cited by examiner, † Cited by third party
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DE102018119148B4 (de) * 2018-08-07 2022-12-29 Maria Angela Carrà Vorrichtung zur Behandlung der Hautoberfläche

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US20040224588A1 (en) * 1998-12-24 2004-11-11 Bki Holding Corporation Absorbent structures of chemically treated cellulose fibers
US20050045296A1 (en) * 2003-08-29 2005-03-03 Adam Gabriel Hammam Stabilized absorbent composite material and method for making
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DE10056062A1 (de) 2000-11-11 2002-06-13 Buheitel Horst Verfahren zum Behandeln von Haar mit einem Wirkstoff
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DE3133434A1 (de) * 1981-08-24 1983-03-10 Gilbert 07041 Millburn N.J. Buchalter Kontaktmedium und verfahren zum befestigen eines messgroessenwandlers an einem patienten
US20040224588A1 (en) * 1998-12-24 2004-11-11 Bki Holding Corporation Absorbent structures of chemically treated cellulose fibers
US20050045296A1 (en) * 2003-08-29 2005-03-03 Adam Gabriel Hammam Stabilized absorbent composite material and method for making
DE102004002990A1 (de) * 2004-01-21 2005-08-18 Robert Dr. Simmoteit Material und Verfahren zum Stoffaustausch und Stofftransfer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012176180A (ja) * 2011-02-28 2012-09-13 Takiron Co Ltd 超音波診断用探触子の装着用スペーサー
WO2014024286A1 (fr) * 2012-08-09 2014-02-13 タキロン株式会社 Écarteur pour montage d'une sonde de diagnostic à ultrasons
CN103654866A (zh) * 2013-11-18 2014-03-26 徐州广安医疗科技有限公司 一种腔内超声探头隔离套
CN109350121A (zh) * 2018-12-19 2019-02-19 邵军 一种自动超声探头无菌套头机
CN109350121B (zh) * 2018-12-19 2024-02-20 邵军 一种自动超声探头无菌套头机

Also Published As

Publication number Publication date
EP2142255A2 (fr) 2010-01-13
DE102007020726A1 (de) 2008-11-20
DE112008001856A5 (de) 2010-04-22
WO2008135011A3 (fr) 2009-03-05
WO2008135011A4 (fr) 2009-04-30

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