WO2008119513A1 - Viskositätsregulator, verfahren zu dessen herstellung und dessen verwendung - Google Patents
Viskositätsregulator, verfahren zu dessen herstellung und dessen verwendung Download PDFInfo
- Publication number
- WO2008119513A1 WO2008119513A1 PCT/EP2008/002492 EP2008002492W WO2008119513A1 WO 2008119513 A1 WO2008119513 A1 WO 2008119513A1 EP 2008002492 W EP2008002492 W EP 2008002492W WO 2008119513 A1 WO2008119513 A1 WO 2008119513A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- emulsion
- starch
- mixtures
- viscosity regulator
- substitution
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/16—Ether-esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Definitions
- Viscosity regulator process for its preparation and its use
- the invention relates to a process for the preparation of a viscosity regulator by introducing hydrophobic as well as hydrophilic groups into a starch molecule. Likewise, the invention relates to viscosity regulators prepared in this way and their use.
- the viscosity regulators of the invention may be used as emulsifiers or as thickeners of surfactant-containing systems, e.g. used in cosmetic or pharmaceutical preparations.
- Thickeners are important auxiliaries in cosmetics and pharmaceutics in order to set a suitable consistency, ie viscosity, for various preparations, for example emulsions or surface-active cleaning products. Certain commercial products, such as hydroxyethylcellulose, may show a slow enzymatic viscosity degradation in the final product. Corresponding enzymes can be entered into the finished product with certain raw materials.
- the overall goal is the synthesis of starch-based hydrophilic-hydrophobic modified thickeners for surfactant-based products based on renewable raw materials.
- the corresponding products should be toxicologically safe, long-term stable and surfactant-compatible and should allow the highest possible transparency of the surfactant finished product.
- thickeners for cosmetic and pharmaceutical preparations find compounds from different classes of substances use.
- PEG derivatives are used as thickeners, which are increasingly critically evaluated in toxicological terms.
- Thickeners are used in various products to provide a suitable consistency, i. Viscosity (K. Schrader, Unen und Phuren der Kosmetika, 3rd edition, Hüthig, Heidelberg 2005, W. Umnbach, Kosmetik und Hygiene, 3rd edition, Wiley-VCH, Weinheim, 2004). Not only is the product viscosity affected, but also the flow behavior as a function of external shear forces.
- inorganic substances such as polysilicic acids or montmorillonites, these are above all organic polymers (E.D. Goddard, J. V. Gruber,
- starch derivatives are used (designations according to INCI, functionalities):
- the said low-substituted sodium carboxymethyl starch shows a highly thickening effect in aqueous systems, but leads to turbid products and is not sufficiently stable to electrolytes.
- non-ionic alkyl polyglycosides which are classified as harmless from a toxicological point of view, are very difficult to thicken.
- a process for the preparation of a viscosity regulator in which starch is firstly hydrophobically modified by alkylation and / or hydroxyalkylation and, in a subsequent step, additionally hydrophilic
- the secondary substitution of the carboxymethyl starch is necessary in order to enable hydrophilic and hydrophobic interactions of the starch derivative with the surfactant.
- the ratio of hydrophilic and hydrophobic functional groups of the starch derivative can be realized by the carboxymethylation for the hydrophilic groups and the alkylation or hydroxyalkylation for the hydrophobic groups.
- starch plays a decisive role in the viscosity and turbidity of surfactant systems in which the viscosity regulator according to the invention is used as thickener.
- starch derivatives could have the required properties as a viscosity regulator, in which first an alkylation or hydroxyalkylation of the starch and then a carboxymethylation were carried out.
- the alkylation is carried out with a linear or branched Ci-C2o-alkyl halide, with linear or branched Ci-Ci 2 -alkyl halides are particularly preferred.
- the alkylation is preferably carried out at temperatures in the range from 40 ° C. to 100 ° C., more preferably in the range from 45 ° C. to 80 ° C.
- the alkylation of the starch is preferably carried out in such a way that the degree of substitution (DS) relates to lent of the alkyl substituents in the range of 0.1 to 1.2 and the degree of substitution with respect to the carboxymethyl substituents in the range of ⁇ 0 to 1.2.
- DS degree of substitution
- Another preferred variant envisages the introduction of hydrophobic groups by hydroxyalkylation with a linear or branched 1,2-epoxyalkane, the alkane preferably having a chain length of 6 to 12 carbon atoms. Particular preference is given here to using linear or branched 1,2-epoxyalkanes, the alkane having a chain length of from 6 to 12 carbon atoms.
- the hydroxyalkylation is carried out at temperatures ranging from 80 0 C to 160 0 C, particularly preferably at temperatures in the range from 100 0 C to 150 0 C.
- the degree of substitution (DS) with respect to the hydroxyalkyl substituents is preferably in the range of 0.1 to 1.2, while the degree of substitution with respect to the carboxycarbyl substituents is in the range of 0.5 to 1.6.
- the halocarboxylic acid is preferably selected from the group consisting of monochloroacetic acid, monoproploropropionic acid, chloromalonic acid and mixtures thereof.
- the starch is preferably selected from the group consisting of potato, wheat, rice, corn, barley, tapioca starch and mixtures thereof.
- a viscosity regulator is also provided which has been prepared by the method described above.
- such surfactant-containing preparation sodium lauryl ether sulfate, which is particularly preferably in a concentration of 0.5 to 3 wt .-%, based on the total preparation is included.
- sodium lauryl ether sulfate causes much clearer emulsions, which have a higher viscosity.
- the viscosity regulator is used in surfactant-containing cleaning products, e.g. shower baths or shampoos used.
- surfactant-containing cleaning products e.g. shower baths or shampoos used.
- Table 1 Two examples of surfactant-containing cleaning products according to the invention are listed in Table 1.
- an oil-in-water emulsion which contains an oil component, a lipophilic or hydrophilic active ingredient and, as emulsifier, at least one viscosity regulator as described above.
- the emulsion preferably contains from 0.1 to 5.0% by weight of the viscosity regulator, based on the total emulsion.
- the emulsion contains alkylpolyglycosides which are particularly preferably present in a concentration of from 0.5 to 20% by weight, in particular from 1 to 15% by weight, based on the total emulsion ,
- the emulsion is in the form of a cream or lotion.
- a further preferred embodiment provides that the emulsion is free of low molecular weight ionic or hydrophilic, nonionic emulsifiers, as they are usually used, and thus show a high care performance on the skin.
- the lipophilic active ingredients contained in the emulsion are preferably selected from the group of vitamins, oil-soluble UV filters, bisabolol, fragrances and mixtures thereof.
- the hydrophilic active ingredients are preferably selected from the group consisting of polyols, for example glycerol or sorbitol, urea, plant extracts, vitamins, self-tanning compounds, for example dihydroxyacetone, UV filters or mixtures thereof.
- the emulsion preferably contains an oil component selected from the group consisting of vegetable oils, for example soybean oil, olive oil or almond oil, paraffin oils, di-N-alkyl ethers, fatty acids, fatty alcohols, ester oils, natural and synthetic waxes, silicone compounds and mixtures thereof.
- the emulsion may contain additives selected from the group consisting of preservatives, solvents, e.g. Alcohols or glycols, antioxidants, fillers, hydrocolloid-forming agents, e.g. Xanthan gum, pigments, chelating agents, e.g. EDTA, pH regulators, e.g. Citric acid, and mixtures thereof.
- solvents e.g. Alcohols or glycols
- antioxidants e.g. Alcohols or glycols
- fillers e.g. Xanthan gum
- hydrocolloid-forming agents e.g. Xanthan gum
- pigments e.g. Xanthan gum
- chelating agents e.g. EDTA
- pH regulators e.g. Citric acid
- Table 2 below shows compositions of O / W emulsions according to the invention.
- the alkaline waxy maize starch is taken up in 2 l of 2-propanol and the solvent is filtered off.
- a solution containing 14% alkylpolyglycoside and 0.5% 2-hydroxypropyl carboxymethyl starch was prepared.
- 0.36 g (atro) of the starch derivative synthesized in Example 2 was dissolved in 51.8 g of distilled water and added to 21.4 g of alkylpolyglycoside. The solution thus prepared is moved for 2 d on a roller mixer.
- Hydroxyoctylcarboxymethyl starch was synthesized by first carboxymethylating the starch and then alkylating it.
- a solution containing 10% alkylpolyglycoside, 2.25% sodium lauryl ether sulfate and 1% 2-hydroxyoctylcarboxymethyl starch was prepared.
- 0.76 g (TG: 92.2%) of the starch derivative synthesized in Example 2 were dissolved in 51.9 g of distilled water and added to a mixture of 15 g of alkylpolyglycoside and 6 g of sodium lauryl ether sulfate.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08734864A EP2142574A1 (de) | 2007-03-29 | 2008-03-28 | Viskositätsregulator, verfahren zu dessen herstellung und dessen verwendung |
US12/593,627 US20100158831A1 (en) | 2007-03-29 | 2008-03-28 | Viscosity Regulator, Method For The Production Thereof, And Use Thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007015282.7A DE102007015282B4 (de) | 2007-03-29 | 2007-03-29 | Viskositätsregulator, Verfahren zu dessen Herstellung und dessen Verwendung |
DE102007015282.7 | 2007-03-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008119513A1 true WO2008119513A1 (de) | 2008-10-09 |
Family
ID=39590709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/002492 WO2008119513A1 (de) | 2007-03-29 | 2008-03-28 | Viskositätsregulator, verfahren zu dessen herstellung und dessen verwendung |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100158831A1 (de) |
EP (1) | EP2142574A1 (de) |
KR (1) | KR20090127167A (de) |
DE (1) | DE102007015282B4 (de) |
WO (1) | WO2008119513A1 (de) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4035572A (en) * | 1975-05-09 | 1977-07-12 | Anheuser-Busch, Incorporated | Method of making chewing gum base |
US4193989A (en) * | 1976-09-27 | 1980-03-18 | Anheuser-Busch, Incorporated | Sunscreen gel |
WO1998029456A1 (en) * | 1996-12-31 | 1998-07-09 | Valtion Teknillinen Tutkimuskeskus | Hydroxyalkylated starch ester and preparation and use thereof |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH240998A (de) * | 1941-04-25 | 1946-02-15 | Scholten Chemische Fab | Verfahren zur Herstellung trockener, in kaltem Wasser löslicher Stärkeprodukte. |
US4427556A (en) * | 1980-10-14 | 1984-01-24 | Nl Industries, Inc. | Dispersible hydrophilic polymer compositions |
DE3238278A1 (de) * | 1982-10-15 | 1984-04-19 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von niedrigsubstituierten, gut wasserloeslichen carboxyalkyl-polysaccharid-(misch-)ethern sowie entsprechende polysaccharid-mischether |
LU87308A1 (fr) * | 1988-08-01 | 1990-03-13 | Oreal | Nouveaux derives de diamino-2,4 pyrimidine oxyde-3 et leur utilisation pour le traitement et la prevention de la chute des cheveux |
DE4010393A1 (de) * | 1990-03-30 | 1991-10-02 | Henkel Kgaa | Verfahren zur herstellung von oel-in-wasser-cremes |
US5482704A (en) * | 1994-06-28 | 1996-01-09 | National Starch And Chemical Investment Holding Corporation | Cosmetic compositions containing amino-multicarboxylate modified starch |
DE4446540A1 (de) * | 1994-12-24 | 1996-06-27 | Hoechst Ag | Verfahren zur Herstellung von wasserlöslichen Aminoalkylderivaten von Polysacchariden |
DE69810472T2 (de) * | 1997-06-13 | 2003-10-02 | Akzo Nobel Nv | Hydrophob modifizierte anionische celluloseether |
DE19808079A1 (de) * | 1998-02-20 | 1999-08-26 | Schering Ag | Hydroxyethylstärke-Konjugate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
EP1109939B1 (de) * | 1998-07-22 | 2003-11-26 | Coöperatieve Verkoop- en Productievereniging van Aardappelmeel en Derivaten 'AVEBE' B.A. | Enthaarungsmittel enthaltend verdicker |
US6440431B1 (en) * | 1998-12-17 | 2002-08-27 | Shiseido Co., Ltd. | Cosmetic composition |
ID29429A (id) * | 1999-01-15 | 2001-08-30 | Cooperetieve Verkoop En Produc | Turunan-turuna pati hidrofobik |
DE10033197C1 (de) * | 2000-07-07 | 2002-01-10 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von hochsubstituierter Carboxymethylstärke |
KR100468432B1 (ko) * | 2002-09-04 | 2005-01-27 | 원영산업 주식회사 | 날염용 다당류의 제조방법 |
DE10308565A1 (de) * | 2003-02-25 | 2004-09-09 | Symrise Gmbh & Co. Kg | Universell einsetzbarer Emulgator vom Typ O/W basierend auf einem voll neutralisierten Phosphorsäureester und Palmglyceriden zur Herstellung von Cremes, Milchen und sehr niederviskosen, sprühfähigen Lotionen |
EP1676821A1 (de) * | 2004-12-29 | 2006-07-05 | Coöperatieve Verkoop- en Productievereniging van Aardappelmeel en Derivaten 'AVEBE' B.A. | Betonformkörper |
DE102006013786A1 (de) * | 2006-03-24 | 2007-09-27 | Wolff Cellulosics Gmbh & Co. Kg | Methylstärkeether in mineralischen Baustoffen |
-
2007
- 2007-03-29 DE DE102007015282.7A patent/DE102007015282B4/de not_active Expired - Fee Related
-
2008
- 2008-03-28 WO PCT/EP2008/002492 patent/WO2008119513A1/de active Application Filing
- 2008-03-28 KR KR1020097021444A patent/KR20090127167A/ko not_active Application Discontinuation
- 2008-03-28 EP EP08734864A patent/EP2142574A1/de not_active Withdrawn
- 2008-03-28 US US12/593,627 patent/US20100158831A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4035572A (en) * | 1975-05-09 | 1977-07-12 | Anheuser-Busch, Incorporated | Method of making chewing gum base |
US4193989A (en) * | 1976-09-27 | 1980-03-18 | Anheuser-Busch, Incorporated | Sunscreen gel |
WO1998029456A1 (en) * | 1996-12-31 | 1998-07-09 | Valtion Teknillinen Tutkimuskeskus | Hydroxyalkylated starch ester and preparation and use thereof |
Also Published As
Publication number | Publication date |
---|---|
KR20090127167A (ko) | 2009-12-09 |
EP2142574A1 (de) | 2010-01-13 |
US20100158831A1 (en) | 2010-06-24 |
DE102007015282A1 (de) | 2008-10-02 |
DE102007015282B4 (de) | 2017-10-05 |
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