WO2008111281A1 - アレルギー疾患の判定方法 - Google Patents

アレルギー疾患の判定方法 Download PDF

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Publication number
WO2008111281A1
WO2008111281A1 PCT/JP2008/000242 JP2008000242W WO2008111281A1 WO 2008111281 A1 WO2008111281 A1 WO 2008111281A1 JP 2008000242 W JP2008000242 W JP 2008000242W WO 2008111281 A1 WO2008111281 A1 WO 2008111281A1
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WO
WIPO (PCT)
Prior art keywords
allergen
specimen
washing
chip
liquid
Prior art date
Application number
PCT/JP2008/000242
Other languages
English (en)
French (fr)
Inventor
Hiroshi Kido
Koichi Suzuki
Original Assignee
The University Of Tokushima
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Tokushima filed Critical The University Of Tokushima
Priority to JP2009503895A priority Critical patent/JP5342997B2/ja
Priority to EP08710396.6A priority patent/EP2136211B1/en
Priority to US12/530,711 priority patent/US20100086939A1/en
Publication of WO2008111281A1 publication Critical patent/WO2008111281A1/ja

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

　唾液、鼻汁、涙液等の血液以外の体液を検体とした場合であっても、微量検体で多角的・網羅的な解析を行うことができ、特に非特異的反応を極力抑制し、高感度で正確に測定することができるアレルギー疾患の判定方法を提供すること。　 　化学修飾したダイヤモンド／ＤＬＣ（Diamond-like Carbon）チップを活性化試薬により活性化した後、アレルゲン又はアレルゲンエピトープを含むペプチドのカップリング反応を行い、次いで未反応活性基の洗浄及びブロッキング操作を行ったアレルゲン判定チップに、低蛋白吸着性フィルターで加圧ろ過した唾液、涙液、鼻汁等の検体を接触させ、アレルゲン判定チップに捕捉された検体中のアレルゲン認識抗体を、標識二次抗体を用いるイムノアッセイにより検出するに際して、前記洗浄及びブロッキング操作に使用する洗浄液及び／又はブロッキング液にグリシン含有液を用いる。
PCT/JP2008/000242 2007-03-12 2008-02-15 アレルギー疾患の判定方法 WO2008111281A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009503895A JP5342997B2 (ja) 2007-03-12 2008-02-15 アレルギー疾患の判定方法
EP08710396.6A EP2136211B1 (en) 2007-03-12 2008-02-15 Determination method for allergic disease
US12/530,711 US20100086939A1 (en) 2007-03-12 2008-02-15 Determination method for allergic disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007061702 2007-03-12
JP2007-061702 2007-03-12

Publications (1)

Publication Number Publication Date
WO2008111281A1 true WO2008111281A1 (ja) 2008-09-18

Family

ID=39759225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000242 WO2008111281A1 (ja) 2007-03-12 2008-02-15 アレルギー疾患の判定方法

Country Status (4)

Country Link
US (1) US20100086939A1 (ja)
EP (1) EP2136211B1 (ja)
JP (1) JP5342997B2 (ja)
WO (1) WO2008111281A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011095132A (ja) * 2009-10-30 2011-05-12 Univ Of Tokushima 乳幼児のアレルギー発症の予測・アレルギーの増悪、改善の判定法
JP2017511478A (ja) * 2014-04-03 2017-04-20 ジェニスフィア・エルエルシー 食物アレルギーを検出するためのペプチド、試薬及び方法
JP2020071512A (ja) * 2018-10-29 2020-05-07 ヤフー株式会社 情報処理装置、情報処理方法及び情報処理プログラム

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5182753B2 (ja) * 2008-09-01 2013-04-17 富士フイルム株式会社 インフルエンザ罹患リスクの予測方法
US8993347B2 (en) * 2009-12-17 2015-03-31 Cornell University Methods for detecting antibodies in mucosal samples and device for sampling mucosal material
CN107449908B (zh) * 2017-07-19 2019-02-22 北京艾旗斯德科技有限公司 一种胶体金刚碳的制备方法及其应用
CN108845137A (zh) * 2018-05-03 2018-11-20 沈阳汇敏源生物科技有限责任公司 基于IgG1抗体捕获食物过敏原的ELISA试剂盒
CN108593933A (zh) * 2018-05-03 2018-09-28 沈阳汇敏源生物科技有限责任公司 基于IgG1抗体检测食物过敏原的ELISA试剂盒
CN110531089A (zh) * 2019-10-10 2019-12-03 首都医科大学附属北京同仁医院 鼻分泌物总IgE胶体金检测卡、试剂盒和应用
CN112881675A (zh) * 2019-11-29 2021-06-01 广东菲鹏生物有限公司 IgM抗体检测稀释液

Citations (8)

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JP2000009728A (ja) * 1998-06-19 2000-01-14 Daikin Ind Ltd 唾液採取分析装置
JP2002303628A (ja) 2001-04-05 2002-10-18 Pola Chem Ind Inc アレルギー病態の鑑別方法
JP2004028953A (ja) * 2002-06-28 2004-01-29 Dna Chip Research Inc 生体関連物質または化学物質固定化用基盤、生体関連物質または化学物質の固定化方法、及び基盤のコーティング方法
WO2004102194A1 (ja) * 2003-05-19 2004-11-25 Toray Industries, Inc. 選択結合性物質固定化担体
JP2005017153A (ja) * 2003-06-27 2005-01-20 Toyobo Co Ltd 金属基板チップに分子を固定化したアレイの作製方法
US6858398B2 (en) 2001-08-14 2005-02-22 Immunosciences Lab., Inc. Saliva test for detection of food allergy and intolerance
JP2006519025A (ja) * 2003-03-04 2006-08-24 独立行政法人産業技術総合研究所 物質を固相支持体に固定するための組成物および方法
JP2006267063A (ja) 2005-03-25 2006-10-05 Univ Of Tokushima アレルギー疾患の判定方法及びアレルギー疾患の判定キット

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US6102872A (en) * 1997-11-03 2000-08-15 Pacific Biometrics, Inc. Glucose detector and method
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CA2443777A1 (en) * 2001-04-10 2002-10-24 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic and diagnostic uses of antibody specificity profiles
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000009728A (ja) * 1998-06-19 2000-01-14 Daikin Ind Ltd 唾液採取分析装置
JP2002303628A (ja) 2001-04-05 2002-10-18 Pola Chem Ind Inc アレルギー病態の鑑別方法
US6858398B2 (en) 2001-08-14 2005-02-22 Immunosciences Lab., Inc. Saliva test for detection of food allergy and intolerance
JP2004028953A (ja) * 2002-06-28 2004-01-29 Dna Chip Research Inc 生体関連物質または化学物質固定化用基盤、生体関連物質または化学物質の固定化方法、及び基盤のコーティング方法
JP2006519025A (ja) * 2003-03-04 2006-08-24 独立行政法人産業技術総合研究所 物質を固相支持体に固定するための組成物および方法
WO2004102194A1 (ja) * 2003-05-19 2004-11-25 Toray Industries, Inc. 選択結合性物質固定化担体
JP2005017153A (ja) * 2003-06-27 2005-01-20 Toyobo Co Ltd 金属基板チップに分子を固定化したアレイの作製方法
JP2006267063A (ja) 2005-03-25 2006-10-05 Univ Of Tokushima アレルギー疾患の判定方法及びアレルギー疾患の判定キット

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011095132A (ja) * 2009-10-30 2011-05-12 Univ Of Tokushima 乳幼児のアレルギー発症の予測・アレルギーの増悪、改善の判定法
JP2017511478A (ja) * 2014-04-03 2017-04-20 ジェニスフィア・エルエルシー 食物アレルギーを検出するためのペプチド、試薬及び方法
US11215615B2 (en) 2014-04-03 2022-01-04 AllerGenis LLC Peptides, reagents and methods for detecting food allergy
JP2020071512A (ja) * 2018-10-29 2020-05-07 ヤフー株式会社 情報処理装置、情報処理方法及び情報処理プログラム
JP7122937B2 (ja) 2018-10-29 2022-08-22 ヤフー株式会社 情報処理装置、情報処理方法及び情報処理プログラム

Also Published As

Publication number Publication date
EP2136211B1 (en) 2013-08-07
EP2136211A4 (en) 2010-08-18
JPWO2008111281A1 (ja) 2010-06-24
JP5342997B2 (ja) 2013-11-13
US20100086939A1 (en) 2010-04-08
EP2136211A1 (en) 2009-12-23

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