WO2008099874A1 - ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法 - Google Patents

ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法 Download PDF

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Publication number
WO2008099874A1
WO2008099874A1 PCT/JP2008/052425 JP2008052425W WO2008099874A1 WO 2008099874 A1 WO2008099874 A1 WO 2008099874A1 JP 2008052425 W JP2008052425 W JP 2008052425W WO 2008099874 A1 WO2008099874 A1 WO 2008099874A1
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WO
WIPO (PCT)
Prior art keywords
pyrazine derivative
pharmaceutical composition
combination
treatment
influenza
Prior art date
Application number
PCT/JP2008/052425
Other languages
English (en)
French (fr)
Inventor
Masako Maekawa
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2008558114A priority Critical patent/JP5255456B2/ja
Priority to KR20097017506A priority patent/KR101479083B1/ko
Priority to CN200880005061XA priority patent/CN101610772B/zh
Priority to PL08711267T priority patent/PL2123276T3/pl
Priority to US12/527,260 priority patent/US8759354B2/en
Priority to DK08711267.8T priority patent/DK2123276T3/da
Priority to SI200830895T priority patent/SI2123276T1/sl
Priority to NZ578989A priority patent/NZ578989A/en
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Priority to ES08711267T priority patent/ES2396595T3/es
Priority to EP08711267A priority patent/EP2123276B1/en
Priority to MX2009008779A priority patent/MX2009008779A/es
Priority to CA2677905A priority patent/CA2677905C/en
Priority to BRPI0807597A priority patent/BRPI0807597B8/pt
Priority to AU2008215397A priority patent/AU2008215397B2/en
Publication of WO2008099874A1 publication Critical patent/WO2008099874A1/ja
Priority to IL200285A priority patent/IL200285A/en
Priority to HRP20130111AT priority patent/HRP20130111T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

一般式 「式中、Ｒ１およびＲ２は、同一または異なって水素原子またはハロゲン原子を；Ｒ３は、水素原子またはアミノ保護基を示す。」で表されるピラジン誘導体またはその塩ならびに一種以上のノイラミニダーゼ阻害剤を含有する医薬組成物は、インフルエンザの治療または予防などの処置に有用であり、これらを組み合わせて使用する方法は、インフルエンザの治療または予防などの処置に有用である。
PCT/JP2008/052425 2007-02-16 2008-02-14 ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法 WO2008099874A1 (ja)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ES08711267T ES2396595T3 (es) 2007-02-16 2008-02-14 Composición farmacéutica que contiene un derivado de pirazina y método de utilización de un derivado de pirazina en combinación
KR20097017506A KR101479083B1 (ko) 2007-02-16 2008-02-14 피라진 유도체를 함유하는 의약조성물 및 피라진 유도체를 조합하여 사용하는 방법
EP08711267A EP2123276B1 (en) 2007-02-16 2008-02-14 Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination
US12/527,260 US8759354B2 (en) 2007-02-16 2008-02-14 Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination
DK08711267.8T DK2123276T3 (da) 2007-02-16 2008-02-14 Farmaceutisk sammensætning omfattende pyrazinderivat og fremgangsmåde til anvendelse af et pyraziderivat i kombination
SI200830895T SI2123276T1 (sl) 2007-02-16 2008-02-14 Farmacevtska sestava, vsebujoča derivat pirazina,in postopek z uporabo derivata pirazina v kombinaciji
NZ578989A NZ578989A (en) 2007-02-16 2008-02-14 Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination
JP2008558114A JP5255456B2 (ja) 2007-02-16 2008-02-14 ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法
CN200880005061XA CN101610772B (zh) 2007-02-16 2008-02-14 包含吡嗪衍生物的药物组合物和使用吡嗪衍生物的联合用药的方法
PL08711267T PL2123276T3 (pl) 2007-02-16 2008-02-14 Kompozycja farmaceutyczna zawierająca pochodną pirazyny oraz sposób stosowania pochodnej pirazyny w kombinacji
MX2009008779A MX2009008779A (es) 2007-02-16 2008-02-14 Composicion farmacéutica que comprende derivado de pirazina y método para usar el derivado de pirazina en combinación.
CA2677905A CA2677905C (en) 2007-02-16 2008-02-14 Pharmaceutical composition comprising pyrazine derivatives and neuraminidase inhibitors for treating influenza infections
BRPI0807597A BRPI0807597B8 (pt) 2007-02-16 2008-02-14 composição farmacêutica, e, uso de um derivado de pirazina ou um sal do mesmo e um ou mais inibidor(es) de neuraminidase em combinação
AU2008215397A AU2008215397B2 (en) 2007-02-16 2008-02-14 Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination
IL200285A IL200285A (en) 2007-02-16 2009-08-06 Pharmaceutical preparation containing a pirazine derivative and its use in combination with one or more neuromidase inhibitors for the preparation of a preparation for the treatment of influenza virus infection
HRP20130111AT HRP20130111T1 (hr) 2007-02-16 2013-02-07 Farmaceutski pripravak koji sadržava derivat pirazina i postupak upotrebe derivata pirazina u kombinaciji

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007035975 2007-02-16
JP2007-035975 2007-02-16

Publications (1)

Publication Number Publication Date
WO2008099874A1 true WO2008099874A1 (ja) 2008-08-21

Family

ID=39690101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052425 WO2008099874A1 (ja) 2007-02-16 2008-02-14 ピラジン誘導体を含有する医薬組成物およびピラジン誘導体を組み合わせて使用する方法

Country Status (21)

Country Link
US (1) US8759354B2 (ja)
EP (1) EP2123276B1 (ja)
JP (1) JP5255456B2 (ja)
KR (1) KR101479083B1 (ja)
CN (1) CN101610772B (ja)
AU (1) AU2008215397B2 (ja)
BR (1) BRPI0807597B8 (ja)
CA (1) CA2677905C (ja)
CY (1) CY1113435T1 (ja)
DK (1) DK2123276T3 (ja)
ES (1) ES2396595T3 (ja)
HR (1) HRP20130111T1 (ja)
IL (1) IL200285A (ja)
MX (1) MX2009008779A (ja)
NZ (1) NZ578989A (ja)
PL (1) PL2123276T3 (ja)
PT (1) PT2123276E (ja)
RU (1) RU2463051C2 (ja)
SI (1) SI2123276T1 (ja)
WO (1) WO2008099874A1 (ja)
ZA (1) ZA200905536B (ja)

Cited By (4)

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JP2014501718A (ja) * 2010-11-18 2014-01-23 アペプティコ・フォルシュング・ウント・エントヴィックルング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ペプチドおよびウイルス・ノイラミニダーゼ阻害剤を含んでなる組成物
JP2016518451A (ja) * 2013-05-14 2016-06-23 バイオクリスト ファーマスーティカルズ，インコーポレイテッドＢｉｏｃｒｙｓｔ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 抗インフルエンザ組成物及び方法
WO2020138067A1 (ja) 2018-12-25 2020-07-02 富士フイルム富山化学株式会社 ピラジン誘導体と細胞内におけるピラジン誘導体リボース三リン酸体の量を増加させる化合物とを組み合わせてなるｒｎａウイルス感染症治療剤
JPWO2021241613A1 (ja) * 2020-05-27 2021-12-02

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WO2010117114A1 (en) * 2009-04-09 2010-10-14 Lg Electronics Inc. Display apparatus
WO2011143262A2 (en) * 2010-05-10 2011-11-17 Sinica, Academia Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses
SG188662A1 (en) 2010-09-30 2013-05-31 Toyama Chemical Co Ltd Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
ES2554630T3 (es) * 2010-09-30 2015-12-22 Toyama Chemical Co., Ltd. Sal sódica de 6-fluoro-3-hidroxi-2-pirazinocarboxamida
CN104402833B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 含有环丁烷取代基的吡嗪类化合物及其组合物及用途
CN104447585B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 吡嗪类化合物及其组合物及用途
CN104447584B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 含有环丁烷取代基的吡嗪类化合物及其组合物及用途
CN104447583B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 含有环丁烷取代基的吡嗪类化合物及其组合物及用途
CN104496918B (zh) * 2014-12-10 2016-08-24 广东东阳光药业有限公司 吡嗪衍生物及其用途
CN104817511B (zh) * 2015-04-27 2017-04-19 济南大学 一种丁烯二酸酐制备法匹拉韦关键中间体的方法
CA3008607A1 (en) * 2015-12-15 2017-06-22 Shionogi & Co., Ltd. A medicament for treating influenza characterized by combining a cap-dependent endonuclease inhibitor and an anti-influenza drug

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014501718A (ja) * 2010-11-18 2014-01-23 アペプティコ・フォルシュング・ウント・エントヴィックルング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ペプチドおよびウイルス・ノイラミニダーゼ阻害剤を含んでなる組成物
US10344055B2 (en) 2010-11-18 2019-07-09 Apeptico Forschung Und Entwicklung Gmbh Composition comprising a peptide and an inhibitor of viral neuraminidase
JP2016518451A (ja) * 2013-05-14 2016-06-23 バイオクリスト ファーマスーティカルズ，インコーポレイテッドＢｉｏｃｒｙｓｔ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 抗インフルエンザ組成物及び方法
WO2020138067A1 (ja) 2018-12-25 2020-07-02 富士フイルム富山化学株式会社 ピラジン誘導体と細胞内におけるピラジン誘導体リボース三リン酸体の量を増加させる化合物とを組み合わせてなるｒｎａウイルス感染症治療剤
JPWO2021241613A1 (ja) * 2020-05-27 2021-12-02
WO2021241613A1 (ja) 2020-05-27 2021-12-02 富士フイルム富山化学株式会社 ピラジン誘導体とチオプリン誘導体を組み合わせてなるｒｎａウイルス感染症治療剤
JP7449379B2 (ja) 2020-05-27 2024-03-13 富士フイルム富山化学株式会社 ピラジン誘導体とチオプリン誘導体を組み合わせてなるｒｎａウイルス感染症治療剤

Also Published As

Publication number Publication date
ES2396595T3 (es) 2013-02-22
CN101610772A (zh) 2009-12-23
ZA200905536B (en) 2010-10-27
SI2123276T1 (sl) 2013-03-29
US8759354B2 (en) 2014-06-24
CY1113435T1 (el) 2016-06-22
HRP20130111T1 (hr) 2013-02-28
RU2463051C2 (ru) 2012-10-10
CN101610772B (zh) 2013-01-16
CA2677905A1 (en) 2008-08-21
IL200285A (en) 2014-06-30
JP5255456B2 (ja) 2013-08-07
EP2123276A4 (en) 2011-05-18
BRPI0807597A2 (pt) 2014-05-06
AU2008215397A1 (en) 2008-08-21
RU2009134516A (ru) 2011-03-27
PL2123276T3 (pl) 2013-04-30
BRPI0807597B8 (pt) 2021-05-25
AU2008215397B2 (en) 2012-09-06
MX2009008779A (es) 2009-11-05
NZ578989A (en) 2011-07-29
KR20090121289A (ko) 2009-11-25
US20100087447A1 (en) 2010-04-08
JPWO2008099874A1 (ja) 2010-05-27
KR101479083B1 (ko) 2015-01-07
EP2123276A1 (en) 2009-11-25
PT2123276E (pt) 2013-01-16
IL200285A0 (en) 2010-04-29
EP2123276B1 (en) 2012-11-28
BRPI0807597B1 (pt) 2021-03-02
CA2677905C (en) 2015-03-24
DK2123276T3 (da) 2013-01-02

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