WO2008092396A1 - Formulation de microcapsules de kitasamycine, son procédé de préparation et son utilisation - Google Patents

Formulation de microcapsules de kitasamycine, son procédé de préparation et son utilisation Download PDF

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Publication number
WO2008092396A1
WO2008092396A1 PCT/CN2008/070128 CN2008070128W WO2008092396A1 WO 2008092396 A1 WO2008092396 A1 WO 2008092396A1 CN 2008070128 W CN2008070128 W CN 2008070128W WO 2008092396 A1 WO2008092396 A1 WO 2008092396A1
Authority
WO
WIPO (PCT)
Prior art keywords
guitarmycin
preparation
microcapsule
pharmaceutically acceptable
stearic acid
Prior art date
Application number
PCT/CN2008/070128
Other languages
English (en)
Chinese (zh)
Inventor
Yuyan Zhou
Original Assignee
Hinapharm Pharmaceutical Co., Ltd. Foshan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hinapharm Pharmaceutical Co., Ltd. Foshan filed Critical Hinapharm Pharmaceutical Co., Ltd. Foshan
Publication of WO2008092396A1 publication Critical patent/WO2008092396A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur une formulation de microcapsules de kitasamycine, sur un procédé pour la préparation de celle-ci et sur son utilisation dans la fabrication d'un agent favorisant la croissance antibactérienne pour la volaille et le bétail. La formulation de microcapsules contient de la kitasamycine et un excipient pharmaceutique, le poids dudit excipient pharmaceutique est de 2-16 fois celui de la kitasamycine, l'excipient pharmaceutique est choisi parmi un ou plusieurs du monostéarate de glycéryle, d'une poudre de matière grasse, d'un acide gras en C12-18, tel que l'acide stéarique. Ladite formulation de microcapsules est préparée par : fusion de l'excipient pharmaceutique par chauffage, son mélange avec de la kitasamycine jusqu'à ce qu'il soit homogène, puis refroidissement par arrosage.
PCT/CN2008/070128 2007-01-30 2008-01-17 Formulation de microcapsules de kitasamycine, son procédé de préparation et son utilisation WO2008092396A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200710026611.3 2007-01-30
CNA2007100266113A CN101045064A (zh) 2007-01-30 2007-01-30 吉他霉素缓释微球制剂及其制备工艺

Publications (1)

Publication Number Publication Date
WO2008092396A1 true WO2008092396A1 (fr) 2008-08-07

Family

ID=38770166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2008/070128 WO2008092396A1 (fr) 2007-01-30 2008-01-17 Formulation de microcapsules de kitasamycine, son procédé de préparation et son utilisation

Country Status (2)

Country Link
CN (2) CN101045064A (fr)
WO (1) WO2008092396A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103372402A (zh) * 2012-04-24 2013-10-30 都江堰市春盛中药饮片有限公司 一种喷雾干燥制粒机

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101611766B (zh) * 2009-07-16 2012-06-06 无锡正大畜禽有限公司 一种饲料用肠溶吉他霉素包衣的生产方法
CN102042964B (zh) * 2010-11-12 2012-07-04 武汉人福药业有限责任公司 乙酰吉他霉素胶囊溶出度的检测方法
CN103288960B (zh) * 2012-02-29 2015-01-07 华中农业大学 吉他霉素残留检测用基因工程抗体及制备方法和应用
CN103478412A (zh) * 2013-09-18 2014-01-01 中粮（北京）饲料科技有限公司 一种微囊化复合维生素预混料及其制备方法
CN104434811A (zh) * 2014-11-07 2015-03-25 浙江大学 一种可嵌于人工晶状体襻上的药物缓释微球及其制备方法
CN105999220B (zh) * 2016-06-30 2023-06-09 石家庄高科动物保健品有限公司 一种恩拉霉素预混剂的制备方法
CN106265595B (zh) * 2016-09-29 2019-05-03 甘肃瑞和祥生物科技有限公司 一种肠溶吉他霉素缓释微球及其制备方法
CN106561998A (zh) * 2016-11-14 2017-04-19 赵清国 一种微囊包被丁酸钠及其制备方法
CN108685871A (zh) * 2018-08-01 2018-10-23 青岛明月海藻集团有限公司 一种吉他霉素微胶囊的制备方法
CN109430560A (zh) * 2018-12-25 2019-03-08 内蒙古金河动物药业有限公司 一种氧化锌饲料添加剂及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05255075A (ja) * 1991-12-04 1993-10-05 Taisho Pharmaceut Co Ltd 矯味経口組成物の製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05255075A (ja) * 1991-12-04 1993-10-05 Taisho Pharmaceut Co Ltd 矯味経口組成物の製造方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103372402A (zh) * 2012-04-24 2013-10-30 都江堰市春盛中药饮片有限公司 一种喷雾干燥制粒机

Also Published As

Publication number Publication date
CN101234097A (zh) 2008-08-06
CN101045064A (zh) 2007-10-03

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