WO2008090731A1 - ２－ニトロイミダゾール誘導体の製造法 - Google Patents

２－ニトロイミダゾール誘導体の製造法 Download PDF

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Publication number
WO2008090731A1
WO2008090731A1 PCT/JP2008/000038 JP2008000038W WO2008090731A1 WO 2008090731 A1 WO2008090731 A1 WO 2008090731A1 JP 2008000038 W JP2008000038 W JP 2008000038W WO 2008090731 A1 WO2008090731 A1 WO 2008090731A1
Authority
WO
WIPO (PCT)
Prior art keywords
producing
nitroimidazole
benzoyloxymethyl
derivative
benzoylglycerin
Prior art date
Application number
PCT/JP2008/000038
Other languages
English (en)
French (fr)
Inventor
Azuma Nishio
Original Assignee
Pola Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Pharma Inc. filed Critical Pola Pharma Inc.
Priority to US12/522,926 priority Critical patent/US8030338B2/en
Priority to JP2008554997A priority patent/JP5213178B2/ja
Priority to AT08702779T priority patent/ATE549319T1/de
Priority to EP08702779A priority patent/EP2128140B1/en
Priority to KR1020097013668A priority patent/KR101408677B1/ko
Publication of WO2008090731A1 publication Critical patent/WO2008090731A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

　放射性同位体を有する誘導体の製造に適した、非環状糖鎖を側鎖に有する２－ニトロイミダゾール誘導体の製造法を提供することを課題とする。 　グリセリンにベンゾイル化剤を反応させて１－Ｏ－ベンゾイルグリセリンを得、１－Ｏ－ベンゾイルグリセリンに脱水剤の存在下にジメトキシメタンを反応させて４－ベンゾイルオキシメチル－１，３－ジオキソランを得、次いでこれに、ルイス酸存在下に２－ニトロイミダゾール又は２－ニトロ－１－トリアルキルシリルイミダゾールを反応させることを特徴とする１－（１－ベンゾイルオキシメチル－２－ヒドロキシエチル）オキシメチル－２－ニトロイミダゾールの製造法。
PCT/JP2008/000038 2007-01-23 2008-01-17 ２－ニトロイミダゾール誘導体の製造法 WO2008090731A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/522,926 US8030338B2 (en) 2007-01-23 2008-01-17 Method for producing 2-nitroimidazole derivative
JP2008554997A JP5213178B2 (ja) 2007-01-23 2008-01-17 ２−ニトロイミダゾール誘導体の製造法
AT08702779T ATE549319T1 (de) 2007-01-23 2008-01-17 Verfahren zur herstellung eines 2-nitroimidazol- derivats
EP08702779A EP2128140B1 (en) 2007-01-23 2008-01-17 Method for producing 2-nitroimidazole derivative
KR1020097013668A KR101408677B1 (ko) 2007-01-23 2008-01-17 2-니트로이미다졸 유도체의 제조법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-012147 2007-01-23
JP2007012147 2007-01-23

Publications (1)

Publication Number Publication Date
WO2008090731A1 true WO2008090731A1 (ja) 2008-07-31

Family

ID=39644306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000038 WO2008090731A1 (ja) 2007-01-23 2008-01-17 ２－ニトロイミダゾール誘導体の製造法

Country Status (7)

Country Link
US (1) US8030338B2 (ja)
EP (1) EP2128140B1 (ja)
JP (1) JP5213178B2 (ja)
KR (1) KR101408677B1 (ja)
AT (1) ATE549319T1 (ja)
TW (1) TWI452036B (ja)
WO (1) WO2008090731A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8258618B2 (en) 2008-11-26 2012-09-04 Mitsubishi Electric Corporation Power semiconductor module

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2475875C2 (ru) * 2010-12-27 2013-02-20 Федеральное государственное унитарное предприятие "Государственный научный центр Российской Федерации - Физико-энергетический институт имени А.И. Лейпунского" Способ нанесения радиоизотопа на вогнутую металлическую поверхность подложки закрытого источника излучения
MD4150C1 (ro) * 2011-10-11 2012-09-30 Институт Химии Академии Наук Молдовы Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective
MD4178C1 (ro) * 2012-02-27 2013-02-28 Институт Химии Академии Наук Молдовы Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului
CN116120262A (zh) * 2023-02-24 2023-05-16 宁德时代新能源科技股份有限公司 氟代环状醚的制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01110675A (ja) 1987-10-22 1989-04-27 Pola Chem Ind Inc ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
JPH0248549A (ja) 1988-08-09 1990-02-19 Kawaken Fine Chem Co Ltd １，３−ジアセトキシ−２−アセトキシメトキシプロパンの製造方法
JPH03223258A (ja) 1990-01-26 1991-10-02 Pola Chem Ind Inc ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤
JPH06228123A (ja) 1993-02-03 1994-08-16 Pola Chem Ind Inc ２−ニトロイミダゾール誘導体の製造法
JPH06279415A (ja) 1993-03-25 1994-10-04 Pola Chem Ind Inc 低酸素性細胞放射線増感剤
JP2003509413A (ja) 1999-09-13 2003-03-11 良尋 高井 新規ニトロイミダゾール誘導体及びこれを含む画像診断薬
JP2005538030A (ja) 2000-06-21 2005-12-15 デュポン ファーマシューティカルズ カンパニー 組み合わせ療法での使用のための血管新生障害の画像診断用医薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3223258B2 (ja) 1992-06-24 2001-10-29 株式会社キーエンス 稼働状態監視装置
JP3989997B2 (ja) * 1997-04-08 2007-10-10 ポーラ化成工業株式会社 放射線増感剤の製造方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01110675A (ja) 1987-10-22 1989-04-27 Pola Chem Ind Inc ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
JPH0248549A (ja) 1988-08-09 1990-02-19 Kawaken Fine Chem Co Ltd １，３−ジアセトキシ−２−アセトキシメトキシプロパンの製造方法
JPH03223258A (ja) 1990-01-26 1991-10-02 Pola Chem Ind Inc ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤
JPH06228123A (ja) 1993-02-03 1994-08-16 Pola Chem Ind Inc ２−ニトロイミダゾール誘導体の製造法
JPH06279415A (ja) 1993-03-25 1994-10-04 Pola Chem Ind Inc 低酸素性細胞放射線増感剤
JP2003509413A (ja) 1999-09-13 2003-03-11 良尋 高井 新規ニトロイミダゾール誘導体及びこれを含む画像診断薬
JP2005538030A (ja) 2000-06-21 2005-12-15 デュポン ファーマシューティカルズ カンパニー 組み合わせ療法での使用のための血管新生障害の画像診断用医薬

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WADA H. ET AL.: "J. Labelled Cpd", RADIOPHARM., vol. 43, no. 8, 2000, pages 785 - 793, XP002167863 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8258618B2 (en) 2008-11-26 2012-09-04 Mitsubishi Electric Corporation Power semiconductor module

Also Published As

Publication number Publication date
KR101408677B1 (ko) 2014-06-17
TWI452036B (zh) 2014-09-11
TW200938527A (en) 2009-09-16
US8030338B2 (en) 2011-10-04
ATE549319T1 (de) 2012-03-15
EP2128140A4 (en) 2010-08-11
KR20090101453A (ko) 2009-09-28
EP2128140A1 (en) 2009-12-02
JP5213178B2 (ja) 2013-06-19
EP2128140B1 (en) 2012-03-14
JPWO2008090731A1 (ja) 2010-05-20
US20100004460A1 (en) 2010-01-07

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