WO2008073313A3 - Dispositifs perméables au gaz particulièrement efficaces et procédés de culture de cellules - Google Patents

Dispositifs perméables au gaz particulièrement efficaces et procédés de culture de cellules Download PDF

Info

Publication number
WO2008073313A3
WO2008073313A3 PCT/US2007/025108 US2007025108W WO2008073313A3 WO 2008073313 A3 WO2008073313 A3 WO 2008073313A3 US 2007025108 W US2007025108 W US 2007025108W WO 2008073313 A3 WO2008073313 A3 WO 2008073313A3
Authority
WO
WIPO (PCT)
Prior art keywords
gas permeable
culture
space
devices
methods
Prior art date
Application number
PCT/US2007/025108
Other languages
English (en)
Other versions
WO2008073313A2 (fr
Inventor
John R Wilson
Original Assignee
Wolf Wilson Mfg Corp
John R Wilson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39512273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008073313(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wolf Wilson Mfg Corp, John R Wilson filed Critical Wolf Wilson Mfg Corp
Priority to CA2671812A priority Critical patent/CA2671812C/fr
Priority to CN2007800510360A priority patent/CN101611132B/zh
Priority to JP2009540319A priority patent/JP5366820B2/ja
Priority to AU2007332869A priority patent/AU2007332869B2/en
Priority to EP07862656.1A priority patent/EP2092052B1/fr
Priority to EP20188610.8A priority patent/EP3770247A1/fr
Publication of WO2008073313A2 publication Critical patent/WO2008073313A2/fr
Publication of WO2008073313A3 publication Critical patent/WO2008073313A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des procédés et des dispositifs qui améliorent l'efficacité dans la culture de cellules. Ces procédés consistent à utiliser des compartiments de culture perméables au gaz qui permettent de réduire l'utilisation d'espace tout en conservant des conditions de culture uniformes, et qui sont plus adaptés à une manipulation automatique des liquides. Ils consistent à intégrer des matériaux perméables au gaz dans le format à plusieurs étages classique, pour résoudre le problème lié aux conditions de culture non uniformes. Ils comprennent des dispositifs de culture qui utilisent des surfaces constituées de silicone perméables au gaz, chargées en plasma et peuvent intégrer des surfaces de fixation classiques, telles que celles constituées de polystyrène traité par culture de tissu classique. Ces procédés concernent des dispositifs de culture qui intègrent des membranes perméables au liquide et perméables au gaz. Ce procédé permet d'obtenir davantage de bénéfices, y compris des conditions de culture optimales pendant la mise à l'échelle et une meilleure utilisation de l'espace de stockage, de l'espace de l'incubateur et de l'espace d'évacuation. De plus les risques de contamination et liés au travail sont réduits.
PCT/US2007/025108 2006-12-07 2007-12-07 Dispositifs perméables au gaz particulièrement efficaces et procédés de culture de cellules WO2008073313A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2671812A CA2671812C (fr) 2006-12-07 2007-12-07 Dispositifs permeables au gaz particulierement efficaces et procedes de culture de cellules
CN2007800510360A CN101611132B (zh) 2006-12-07 2007-12-07 高效透气装置及培养细胞的方法
JP2009540319A JP5366820B2 (ja) 2006-12-07 2007-12-07 細胞培養に効果的な装置および方法
AU2007332869A AU2007332869B2 (en) 2006-12-07 2007-12-07 Highly efficient gas permeable devices and methods for culturing cells
EP07862656.1A EP2092052B1 (fr) 2006-12-07 2007-12-07 Dispositifs perméables au gaz particulièrement efficaces de culture de cellules
EP20188610.8A EP3770247A1 (fr) 2006-12-07 2007-12-07 Dispositifs perméables au gaz particulièrement efficaces et procédés de culture de cellules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87334706P 2006-12-07 2006-12-07
US60/873,347 2006-12-07

Publications (2)

Publication Number Publication Date
WO2008073313A2 WO2008073313A2 (fr) 2008-06-19
WO2008073313A3 true WO2008073313A3 (fr) 2008-07-31

Family

ID=39512273

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/025110 WO2008073314A2 (fr) 2006-12-07 2007-12-07 Dispositifs et procédés particulièrement efficaces dans la culture de cellules
PCT/US2007/025108 WO2008073313A2 (fr) 2006-12-07 2007-12-07 Dispositifs perméables au gaz particulièrement efficaces et procédés de culture de cellules

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2007/025110 WO2008073314A2 (fr) 2006-12-07 2007-12-07 Dispositifs et procédés particulièrement efficaces dans la culture de cellules

Country Status (7)

Country Link
US (8) US20080176318A1 (fr)
EP (3) EP2089507A4 (fr)
JP (2) JP2010512149A (fr)
CN (2) CN101611132B (fr)
AU (2) AU2007332869B2 (fr)
CA (2) CA2671812C (fr)
WO (2) WO2008073314A2 (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103173354B (zh) * 2003-10-08 2017-07-14 威尔森沃尔夫制造公司 利用透气性材料进行细胞培养的方法及装置
EP3029135B1 (fr) 2005-07-07 2021-03-17 The Regents of the University of California Appareil pour réseau de culture cellulaire
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US7745209B2 (en) * 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
US20080176318A1 (en) 2006-12-07 2008-07-24 Wilson John R Highly efficient devices and methods for culturing cells
EP3173787B1 (fr) 2008-01-03 2021-06-02 EMD Millipore Corporation Système de réseau de culture de cellules pour épreuves automatisées et procédés de fonctionnement et de fabrication de celui-ci
AU2009268666B2 (en) * 2008-07-08 2014-11-13 Wilson Wolf Manufacturing, LLC Improved gas permeable cell culture device and method of use
EP4176888A1 (fr) * 2008-11-14 2023-05-10 ViaCyte, Inc. Encapsulation de cellules pancréatiques dérivées de cellules souches pluripotentes humaines
EP2698425B1 (fr) * 2009-02-25 2015-09-09 Corning Incorporated Système de culture cellulaire avec collecteur
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
GB0914195D0 (en) * 2009-08-13 2009-09-16 Plasticell Ltd Vessel for culturing cells
RU2012111349A (ru) * 2009-08-24 2013-10-27 Байлор Колледж Оф Медсин Генерация линий ctl со специфичностью против множества опухолевых антигенов или множества вирусов
US8956860B2 (en) 2009-12-08 2015-02-17 Juan F. Vera Methods of cell culture for adoptive cell therapy
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
KR20130109000A (ko) * 2010-05-11 2013-10-07 아르텔리스 에스에이 세포 배양 장치 및 방법
US9574166B2 (en) 2010-08-18 2017-02-21 Drugmode Aps Bioreactor system
WO2012039996A1 (fr) * 2010-09-22 2012-03-29 Corning Incorporated Système de visualisation pour dispositif de culture cellulaire
JP6073794B2 (ja) * 2010-10-22 2017-02-01 ライフライン サイエンティフィック インコーポレイテッドＬｉｆｅｌｉｎｅ Ｓｃｉｅｎｔｉｆｉｃ， Ｉｎｃ． 培養膵島
US10100273B2 (en) 2010-11-22 2018-10-16 Corning Incorporated Closure assembly for cell culture apparatus
CN103261395B (zh) 2010-12-15 2017-09-08 药物模式有限责任公司 具有便于进入培养腔的盖子的生物反应器
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
CN102304476B (zh) * 2011-08-22 2013-10-09 陕西师范大学 三维细胞动态培养反应器
CN104245917B (zh) 2011-12-03 2017-07-21 Emd密理博公司 用于微流体细胞培养的微型培育系统和方法
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
ES2928851T3 (es) 2012-02-09 2022-11-23 Baylor College Medicine Mezclas pep para generar CTL multivíricos con amplia especificidad
CN102643744A (zh) * 2012-04-18 2012-08-22 广州洁特生物过滤制品有限公司 一种高通量细胞培养器及其制造方法
JP6386447B2 (ja) * 2012-05-18 2018-09-05 ウィルソン ウォルフ マニュファクチャリング コーポレイションＷｉｌｓｏｎ Ｗｏｌｆ Ｍａｎｕｆａｃｔｕｒｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ 養子細胞療法のための改良された細胞培養法
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
US9790465B2 (en) 2013-04-30 2017-10-17 Corning Incorporated Spheroid cell culture well article and methods thereof
SG11201510526VA (en) 2013-06-24 2016-01-28 Wolf Wilson Mfg Corp Closed system device and methods for gas permeable cell culture process
AU2014324102B2 (en) 2013-09-23 2021-01-28 Wilson Wolf Manufacturing, LLC Improved methods of genetically modifying animal cells
JP2016077164A (ja) * 2014-10-10 2016-05-16 大日本印刷株式会社 細胞培養容器
KR102527308B1 (ko) * 2014-10-29 2023-04-28 코닝 인코포레이티드 3d 세포 응집체의 생성 및 배양을 위한 장치 및 방법
SG11201703493SA (en) 2014-10-29 2017-05-30 Corning Inc Cell culture insert
JP6930914B2 (ja) 2014-10-29 2021-09-01 コーニング インコーポレイテッド 灌流バイオリアクタ・プラットフォーム
US10421937B2 (en) * 2015-03-05 2019-09-24 Saint-Gobain Performance Plastics Corporation High gas flow rate bio-reactive container filter apparatus
CA2985350A1 (fr) * 2015-05-08 2016-11-17 Wilson Wolf Manufacturing Procedes de culture ameliores et dispositifs de test
JP6999941B2 (ja) 2015-09-18 2022-02-10 ベイラー カレッジ オブ メディスン 病原体からの免疫原性抗原同定および臨床的有効性との相関
EP3370850A4 (fr) * 2015-11-04 2019-08-28 Thrive Bioscience, Inc. Incubateurs de culture cellulaire automatisés comprenant des compartiments de stockage de récipients de culture cellulaire à perméabilité sélective
EP3478818A2 (fr) * 2016-06-29 2019-05-08 Northeastern University Chambres de culture cellulaire et leurs procédés d'utilisation
US10053660B2 (en) 2016-07-12 2018-08-21 California Institute Of Technology Substrates for high-density cell growth and metabolite exchange
JP2018033387A (ja) * 2016-08-31 2018-03-08 株式会社アステック 細胞培養容器
JP7118059B2 (ja) * 2016-11-02 2022-08-15 イー・エム・デイー・ミリポア・コーポレイシヨン 細胞培養液からマイクロキャリアを分離するための容器
CN106754638A (zh) * 2016-12-01 2017-05-31 长春生物制品研究所有限责任公司 过co2多层细胞培养瓶人二倍体细胞贴壁培养方法
WO2018195014A1 (fr) 2017-04-19 2018-10-25 Neubiser Richard Bioréacteur pour substance biologique
US10821134B2 (en) 2017-05-17 2020-11-03 Board Of Regents, The University Of Texas System BK virus specific T cells
EP3652294A1 (fr) * 2017-07-14 2020-05-20 Corning Incorporated Récipient de culture cellulaire
WO2019014636A1 (fr) 2017-07-14 2019-01-17 Corning Incorporated Récipient de culture de cellules
US11857970B2 (en) 2017-07-14 2024-01-02 Corning Incorporated Cell culture vessel
EP3652290B1 (fr) 2017-07-14 2022-05-04 Corning Incorporated Récipients de culture cellulaire 3d pour échange de milieu manuel ou automatique
JP7195302B2 (ja) 2017-07-14 2022-12-23 コーニング インコーポレイテッド ３ｄ培養のための細胞培養容器及び３ｄ細胞の培養方法
CN107287118A (zh) * 2017-08-22 2017-10-24 江苏健安生物科技有限公司 一种模块式细胞培养和运输组件
US11866683B2 (en) 2017-11-06 2024-01-09 Corning Incorporated Cell culture apparatuses with manifolds including column structures
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
EP3649229B1 (fr) 2018-07-13 2021-08-25 Corning Incorporated Flacons de culture cellulaire dotés de dispositifs stabilisateurs
CN111032851B (zh) 2018-07-13 2024-03-29 康宁股份有限公司 具有包含液体介质传递表面的侧壁的微腔皿
JP7171696B2 (ja) 2018-07-13 2022-11-15 コーニング インコーポレイテッド 相互接続されたウェルを有するマイクロプレートを備えた流体デバイス
CN109207364A (zh) * 2018-10-11 2019-01-15 广州洁特生物过滤股份有限公司 一种细胞培养器
US10647954B1 (en) 2018-11-15 2020-05-12 Flaskworks, Llc Dendritic cell generating apparatus and method
US11850320B2 (en) * 2018-12-20 2023-12-26 Asp Global Manufacturing Gmbh Liquid-chemical sterilization system with biological indicator
EP3906295A1 (fr) * 2019-01-04 2021-11-10 Oribiotech Ltd Unité de traitement de cellule, système de traitement de cellule et procédés d'utilisation correspondants
US10772914B1 (en) 2019-04-18 2020-09-15 Baylor College Of Medicine EBV-specific immune cells
CN110218649A (zh) * 2019-07-02 2019-09-10 英诺维尔智能科技（苏州）有限公司 一种新型两侧透气多层贴壁细胞培养容器结构
US11566217B2 (en) 2019-08-13 2023-01-31 Flaskworks, Llc Duty cycle for cell culture systems
AU2020369940A1 (en) 2019-10-21 2022-05-26 Flaskworks, Llc Systems and methods for cell culturing
EP4048773A4 (fr) * 2019-10-24 2024-01-03 Octane Biotech Inc. Chambre de culture cellulaire présentant des surfaces de contact cellulaire améliorées
CA210152S (en) * 2019-10-28 2022-06-03 Nipro Corp Culture container
US11981885B2 (en) 2019-11-15 2024-05-14 City Of Hope System, device and method for production of bioproduct including high density cell respirator (HDCR) for intensified production of adeno-associated viruses (AAV) and cell-based production
EP4107247A2 (fr) 2020-03-10 2022-12-28 Cellares Corporation Systèmes, dispositifs et procédés de traitement de cellules
US20210371788A1 (en) * 2020-05-26 2021-12-02 Cesco Bioengineering Co., Ltd. Apparatus and method for culturing cells
WO2023077096A1 (fr) * 2021-10-29 2023-05-04 Nextern Innovation, Llc Système de culture cellulaire à conditions limites de transfert gazeux régulées
CN115058338A (zh) * 2022-06-24 2022-09-16 楚天思为康基因科技(长沙)有限公司 一种细胞培养方法及细胞培养容器

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228243A (en) * 1978-07-13 1980-10-14 Toray Industries, Inc. Cell culture propagation apparatus
US4839292A (en) * 1987-09-11 1989-06-13 Cremonese Joseph G Cell culture flask utilizing a membrane barrier
US5693537A (en) * 1994-06-28 1997-12-02 Wilson; John R. Compartmentalized tissue culture flask
US6228607B1 (en) * 1995-04-28 2001-05-08 Organogenesis Inc. Bioreactor

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459176A (en) * 1966-06-24 1969-08-05 Beckman Instruments Inc Apparatus and method of sampling a dialyzable component of blood
GB1376131A (en) * 1971-02-09 1974-12-04 Nat Res Dev Improvements in and relating to cell culture systems
US3941662A (en) 1971-06-09 1976-03-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Apparatus for culturing cells
DE2128744C3 (de) * 1971-06-09 1979-03-29 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Verfahren zur Massenkultivation von Zellen und Geweben
JPS5123182B1 (fr) 1971-07-14 1976-07-15
US3839155A (en) * 1972-07-27 1974-10-01 Merck & Co Inc Cell and vaccine production
US3870602A (en) * 1973-04-30 1975-03-11 California Lab Ind Inc Gas permeable sterile culture bottle
US3948732A (en) 1973-05-31 1976-04-06 Instrumentation Laboratory, Inc. Cell culture assembly
US3941661A (en) * 1974-01-16 1976-03-02 The Curators Of The University Of Missouri Roller culture bottle insert
JPS5238082A (en) 1975-09-13 1977-03-24 Heraeus Gmbh W C Cultivating container for microorganism * bacterium and tissue
GB1539263A (en) 1976-11-19 1979-01-31 Toray Industries Apparatus and methods for growing cells
DE2940446C2 (de) 1979-10-05 1982-07-08 B. Braun Melsungen Ag, 3508 Melsungen Züchtung von tierischen Zellen in Suspensions- und Monolayerkulturen in Fermentationsgefäßen
US4296205A (en) * 1980-02-22 1981-10-20 Verma Dharmvir S Cell culture and continuous dialysis flask and method
US4317886A (en) * 1980-08-11 1982-03-02 Becton, Dickinson And Company Multiple interior surface roller bottle
US4435508A (en) * 1981-11-20 1984-03-06 Gabridge Michael G Tissue culture vessel
US4640895A (en) * 1982-10-15 1987-02-03 Gibco Division, The Mogul Corporation Biphasic media culture apparatus
JPS59220182A (ja) 1983-05-27 1984-12-11 Ishikawa Seisakusho:Kk 培養槽
DE3409501A1 (de) 1984-03-15 1985-10-24 Sandoz-Patent-GmbH, 7850 Lörrach Verfahren zur kultivierung von zellen
US4748124A (en) * 1984-10-30 1988-05-31 E. I. Du Pont De Nemours And Company Compartmentalized cell-culture device and method
US4668632A (en) * 1985-02-06 1987-05-26 Vxr, Inc. Sparger and apparatus for and method of growing cells
US4654308A (en) * 1985-06-19 1987-03-31 La Corporation De L'ecole Polytechnique Bioreactor
EP0264464B1 (fr) 1985-10-19 1992-05-13 Daikin Industries, Limited Récipient de culture
US4661455A (en) * 1986-01-16 1987-04-28 Dorr-Oliver Incorporated Membrane cell culturing device
US4937194A (en) 1986-05-12 1990-06-26 Baxter International Inc. Method for metering nutrient media to cell culture containers
US4829002A (en) 1986-05-12 1989-05-09 Baxter International Inc. System for metering nutrient media to cell culture containers and method
US4734373A (en) * 1986-06-24 1988-03-29 Bartal Arie H Apparatus for enhancing cell growth, preservation and transport
DE3628930A1 (de) * 1986-08-26 1988-05-05 Greiner & Soehne C A Kontaminationssicherer verschluss, insbesondere schraubverschluss fuer zellkulturflaschen
US4945203A (en) 1986-11-06 1990-07-31 American Fluoroseal Corporation Method and apparatus for making fluorocarbon film plastic bags using a laser
US4847462A (en) * 1986-11-06 1989-07-11 American Fluoroseal Corporation Method and apparatus for making fluorocarbon film plastic bags using a laser
US4717668A (en) * 1986-12-12 1988-01-05 Baxter Travenol Laboratories, Inc. Plastic roller bottle for suspension cultures
CA1300058C (fr) 1987-01-29 1992-05-05 Joseph D. Irr Procede de preparation de lymphocytes k actives
JPH0134283Y2 (fr) 1987-04-15 1989-10-18
US5786215A (en) 1987-05-20 1998-07-28 Baxter International Inc. Method for culturing animal cells
JP2509630B2 (ja) 1987-07-29 1996-06-26 三井石油化学工業株式会社 培養方法及び培養装置
US5047347A (en) * 1987-08-17 1991-09-10 Cline Martin J Gas permeable culture flask and method for culturing mammalian cells
US4829004A (en) * 1987-11-24 1989-05-09 The University Of Michigan Roller bottle system
US4824787A (en) * 1987-12-09 1989-04-25 In Vitro Scientific Products, Inc. Roller bottle for tissue culture growth
US5026650A (en) * 1988-06-30 1991-06-25 The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration Horizontally rotated cell culture system with a coaxial tubular oxygenator
US5153131A (en) * 1990-12-11 1992-10-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High aspect reactor vessel and method of use
CA1307225C (fr) * 1988-07-19 1992-09-08 David W. Armstrong Bioreacteur pour la culture de cellules
US5416022A (en) 1988-08-10 1995-05-16 Cellex Biosciences, Inc. Cell culture apparatus
US5079168A (en) 1988-08-10 1992-01-07 Endotronics, Inc. Cell culture apparatus
DE68926421T2 (de) * 1988-08-20 1996-09-12 Nitto Denko Corp Verfahren zur Entfernung von gelösten Gasen aus einer Flüssigkeit
US4939151A (en) * 1988-10-31 1990-07-03 Baxter International Inc. Adherent cell culture flask
US5068195A (en) * 1988-11-02 1991-11-26 Du Pont Merck Pharmaceutical Company Dot matrix membrane cell expansion and maintenance vessel
US5139946A (en) 1988-11-02 1992-08-18 Du Pont Merck Pharmaceutical Company Dot matrix membrane cell expansion
US5017490A (en) 1989-03-10 1991-05-21 Baxter International Inc. Method for in vitro reproduction and growth of cells in culture medium
US4897359A (en) 1989-03-27 1990-01-30 Bio-Response, Inc. Apparatus for oxygenating culture medium
US4960706A (en) * 1989-03-27 1990-10-02 Baxter International, Inc. Static oxygenator for suspension culture of animal cells
US4912058A (en) * 1989-04-27 1990-03-27 Becton, Dickinson And Company Roller bottle
CA2015294A1 (fr) 1989-04-28 1990-10-28 John J. Rinehart Generation et expansion de cellules lak
US5240854A (en) * 1989-06-05 1993-08-31 Berry Eric S Continuous high-density cell culture system
US4937196A (en) * 1989-08-18 1990-06-26 Brunswick Corporation Membrane bioreactor system
US5173225A (en) * 1990-05-07 1992-12-22 Bowolfe, Inc. Method for making ultra-thin dense skin membrane
EP0471947A1 (fr) * 1990-06-29 1992-02-26 Sekisui Chemical Co., Ltd. Sac de culture
FR2666094A1 (fr) 1990-08-22 1992-02-28 Cyclopore Sa Bouteille de culture en masse de cellules et procede pour son assemblage.
US5139951A (en) * 1990-10-10 1992-08-18 Costar Corporation Culture device having a detachable cell or tissue growth surface
US5650325A (en) * 1990-11-29 1997-07-22 Spielmann; Richard Apparatus having a rotatable stack of parallel trays with culturing surfaces on opposite sides for liquid/gas exchange
CA2055966C (fr) * 1990-12-19 1995-08-01 Oresta Natalia Fedun Dispositif d'insertion de culture cellulaire
CA2062100C (fr) * 1991-03-05 2000-10-31 Hirotoshi Fujisawa Cartouche de disque
GB9112836D0 (en) * 1991-06-14 1991-07-31 Medical Res Council Production of monoclonal antibodies
JPH05123182A (ja) 1991-10-30 1993-05-21 Nakano Vinegar Co Ltd 静置培養による微生物セルロースの製造法及びその装置
US5310676A (en) * 1991-11-15 1994-05-10 A/S Nunc Cell cultivating device
DE4206585C2 (de) 1992-03-03 1994-11-24 Augustinus Dr Med Bader Vorrichtung zur Massenkultur von Zellen
DE4214157C1 (fr) * 1992-04-29 1993-08-05 Degussa Ag, 6000 Frankfurt, De
GB2268187A (en) 1992-07-01 1994-01-05 Univ Hull Cell culture vessels
DE4229325C2 (de) * 1992-09-02 1995-12-21 Heraeus Instr Gmbh Kulturgefäß für Zellkulturen
DE4229334C2 (de) 1992-09-02 1995-12-21 Heraeus Instr Gmbh Rollflaschenähnliches Kulturgefäß für Zellkulturen
US5330908A (en) * 1992-12-23 1994-07-19 The United States Of America As Represented By The Administrator, National Aeronautics And Space Administration High density cell culture system
US5462874A (en) 1993-06-23 1995-10-31 Wolf; Martin L. Dialyzed multiple well tissue culture plate
JP2749245B2 (ja) 1993-06-25 1998-05-13 鹿島建設株式会社 付着微細藻類の培養方法
US5324428A (en) * 1993-07-19 1994-06-28 Spectrum Medical Industries, Inc. Disposable dialysis apparatus
JPH0734699A (ja) 1993-07-21 1995-02-03 Ishikawajima Harima Heavy Ind Co Ltd エレベータ式駐車装置
AT401476B (de) 1993-08-20 1996-09-25 Sy Lab Vertriebsges M B H Thermokammer
US5686301A (en) * 1993-09-02 1997-11-11 Heraeus Instruments Gmbh Culture vessel for cell cultures
US5437998A (en) * 1993-09-09 1995-08-01 Synthecon, Inc. Gas permeable bioreactor and method of use
US5702941A (en) 1993-09-09 1997-12-30 Synthecon, Inc. Gas permeable bioreactor and method of use
PT720508E (pt) * 1993-09-22 2000-09-29 Pierce Chemical Co Dispositivo para dialisar amostras
FR2710492B1 (fr) * 1993-09-29 1997-08-01 Compac Int Inc Sac pour la culture de blanc de champignon.
US5534423A (en) * 1993-10-08 1996-07-09 Regents Of The University Of Michigan Methods of increasing rates of infection by directing motion of vectors
EP0760008A1 (fr) * 1994-05-19 1997-03-05 Dako A/S Sondes d'acide nucleique peptidique de detection de neisseria gonorrhoeae et de chlamydia trachomatis
US5714384A (en) 1994-06-28 1998-02-03 Wilson; John R. Compartmentalized tissue culture bag
ATE292673T1 (de) * 1994-06-28 2005-04-15 Wilson Wolf Corp Zellkulturflasche mit mehreren kammern
US5707869A (en) * 1994-06-28 1998-01-13 Wolf; Martin L. Compartmentalized multiple well tissue culture plate
US5527705A (en) 1994-09-12 1996-06-18 Becton, Dickinson And Company Roller bottle for trans-membrane co-culture of cells and method for its use
US5935847A (en) 1994-10-28 1999-08-10 Baxter International Inc. Multilayer gas-permeable container for the culture of adherent and non-adherent cells
US6297046B1 (en) 1994-10-28 2001-10-02 Baxter International Inc. Multilayer gas-permeable container for the culture of adherent and non-adherent cells
DE19537774C2 (de) 1994-11-18 1996-09-19 Heraeus Instr Gmbh Verfahren zur Zellkultivierung und Vorrichtung zur Durchführung des Verfahrens
EP0725134A3 (fr) 1995-02-03 1998-05-13 NPBI Nederlands Produktielaboratorium voor Bloedtransfusieapparatuur en Infusievloeistoffen B.V. Bioréacteur flexible pour cellules thérapeutiques
DE19504958C1 (de) 1995-02-15 1995-11-02 Heraeus Instr Gmbh Verfahren für die Kultivierung von Zellen auf einem Träger, Vorrichtung zur Durchführung des Verfahrens und Verwendung der Vorrichtung
CA2175626C (fr) * 1995-05-18 1999-08-03 Timothy A. Stevens Fiole pour culture tissulaire
US5985653A (en) * 1995-06-07 1999-11-16 Aastrom Biosciences, Inc. Incubator apparatus for use in a system for maintaining and growing biological cells
US5759847A (en) * 1995-07-14 1998-06-02 Difco Laboratories System and apparatus for automatically transferring media
DE19529099C2 (de) * 1995-08-08 1997-12-04 Forschungszentrum Juelich Gmbh Vorrichtung zur Serien-Kultivierung von Mikroorganismen bzw. Zellen in begasten Flüssigkeitssäulen
DE69612861T2 (de) * 1995-08-31 2001-08-30 Ashby Scientific Ltd., Coalville Verfahren und vorrichtung zur kultivierung von biologischem material
US5614412A (en) * 1995-09-08 1997-03-25 Smith; Stephen L. Apparatus for carrying flexible containers and method of transferring fluids to containers
US5686304A (en) * 1995-12-15 1997-11-11 Avecor Cardiovascular, Inc. Cell culture apparatus and method
US5763267A (en) 1996-04-16 1998-06-09 Advanced Tissue Sciences Apparatus for the large scale growth and packaging of cell suspensions and three-dimensional tissue cultures
US5866419A (en) * 1996-09-16 1999-02-02 Meder; Martin G. Roller bottle
US5876604A (en) * 1996-10-24 1999-03-02 Compact Membrane Systems, Inc Method of gasifying or degasifying a liquid
US6306491B1 (en) 1996-12-20 2001-10-23 Gore Enterprise Holdings, Inc. Respiratory aids
US5736398A (en) 1997-01-16 1998-04-07 Board Of Regents, The University Of Texas System Gas permeable pouches for growing cultures
US5817509A (en) 1997-03-19 1998-10-06 Becton Dickinson And Company Culture vessel assembly
US5928936A (en) * 1997-04-09 1999-07-27 Huntington Medical Research Institutes Cell culture container that self-seals after cannula penetration made of porous sheets
DE19719751A1 (de) * 1997-05-10 1998-11-12 Augustinus Dr Med Bader Vorrichtung zum Züchten und/oder Behandeln von Zellen
US5914154A (en) 1997-05-30 1999-06-22 Compact Membrane Systems, Inc. Non-porous gas permeable membrane
US5783075A (en) * 1997-06-23 1998-07-21 Spectrum Medical Laboratories, Inc. Disposable dialyzer apparatus
JP3761676B2 (ja) 1997-07-11 2006-03-29 株式会社メニコン 細胞培養用容器
WO1999004911A1 (fr) 1997-07-28 1999-02-04 Massachusetts Institute Of Technology Depot chimique pyrolytique en phase vapeur de films de silicone
US6190913B1 (en) * 1997-08-12 2001-02-20 Vijay Singh Method for culturing cells using wave-induced agitation
US6596532B1 (en) * 1997-12-12 2003-07-22 BIOMéRIEUX, INC. Device for isolation and surface culture of microorganisms from bulk fluids
GB9803362D0 (en) * 1998-02-17 1998-04-15 Cellon Sa A cell culture vessel
US5989913A (en) * 1998-07-02 1999-11-23 Charles Daniel Anderson Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using the same
EP1124592B1 (fr) * 1998-10-28 2006-06-07 Cellon S.A. Caoutchouc de silicone poreux et texture
GB9912641D0 (en) 1999-05-28 1999-07-28 Ashby Scient Ltd Textured and porous silicone rubber
US6455310B1 (en) 1999-03-23 2002-09-24 Biocrystal Ltd. Cell culture apparatus and method for culturing cells
US6410309B1 (en) * 1999-03-23 2002-06-25 Biocrystal Ltd Cell culture apparatus and methods of use
DE19915611A1 (de) * 1999-04-07 2000-11-16 Augustinus Bader Rollhalterung
US7560274B1 (en) * 1999-05-28 2009-07-14 Cellon S.A. Culture chamber
ATE373079T1 (de) 1999-06-21 2007-09-15 Gen Hospital Corp Zellkultursysteme und verfahren für einrichtungen zur organunterstützung
US6562616B1 (en) * 1999-06-21 2003-05-13 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
US6569675B2 (en) * 2000-06-16 2003-05-27 Corning Incorporated Cell cultivating flask and method for using the cell cultivating flask
JP2004502785A (ja) 2000-07-11 2004-01-29 サウンド・ファーマシューティカルズ・インコーポレイテッド 内耳における細胞の再生および分化の刺激
EP1326961B1 (fr) 2000-09-15 2007-08-22 Ortho-McNeil Pharmaceutical, Inc. Compositions et methodes destinees a induire des reponses cytolytiques specifiques chez des lymphocytes t
AU2002237705A1 (en) 2000-11-13 2002-06-11 University Of Utah Research Foundation Method and apparatus for multi-layer growth of anchorage-dependent cells
EP2230297B1 (fr) 2000-11-21 2015-03-11 Biocrystal, Ltd. Appareils de culture cellulaire et des méthodes pour son utilisation
US20030077816A1 (en) * 2000-12-27 2003-04-24 Richard Kronenthal Bioreactor and method for using
DE10109706B4 (de) 2001-02-11 2006-03-09 In Vitro Systems & Services Gmbh Verfahren zur Herstellung von Kulturgefäßen
US20020110905A1 (en) 2001-02-15 2002-08-15 Emilio Barbera-Guillem Perfusion system for cultured cells
EP1245670A3 (fr) 2001-03-27 2004-01-28 Becton, Dickson and Company Procédé et appareil pour la culture de cellules
KR20020088848A (ko) 2001-05-21 2002-11-29 (주)코아바이오텍 세포배양관 및 이를 이용한 대량 세포배양기
US20040072347A1 (en) * 2001-07-27 2004-04-15 Gerold Schuler Generation of fully mature and stable dendritic cells from leukaphereses products for clinical applications
US6673595B2 (en) 2001-08-27 2004-01-06 Biocrystal, Ltd Automated cell management system for growth and manipulation of cultured cells
WO2003060061A1 (fr) 2001-12-21 2003-07-24 Organogenesis Inc. Chambre a volume adaptable pour culture cellulaire et assistance d'organe
US7033823B2 (en) * 2002-01-31 2006-04-25 Cesco Bioengineering, Inc. Cell-cultivating device
US7507579B2 (en) * 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US7229820B2 (en) 2002-06-13 2007-06-12 Wilson Wolf Manufacturing Corporation Apparatus and method for culturing and preserving tissue constructs
US20040029266A1 (en) * 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
US20040110199A1 (en) * 2002-08-28 2004-06-10 Montemagno Carlo D. Microfluidic affinity system using polydimethylsiloxane and a surface modification process
US20040067585A1 (en) * 2002-10-07 2004-04-08 Yu-Chi Wang Cell cultivation surface and method of making the same
JP2004129568A (ja) 2002-10-10 2004-04-30 Olympus Corp 培養容器および培養方法
US7176024B2 (en) * 2003-05-30 2007-02-13 Biolex, Inc. Bioreactor for growing biological materials supported on a liquid surface
US20050032205A1 (en) * 2003-08-05 2005-02-10 Smith Sidney T. In vitro cell culture employing a fibrin network in a flexible gas permeable container
CN103173354B (zh) * 2003-10-08 2017-07-14 威尔森沃尔夫制造公司 利用透气性材料进行细胞培养的方法及装置
US7078228B2 (en) * 2003-12-31 2006-07-18 Corning Incorporated Cell cultivating flask
CN2892872Y (zh) * 2005-07-21 2007-04-25 高春平 自动细胞培养装置
US7745209B2 (en) * 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
WO2007020598A2 (fr) 2005-08-17 2007-02-22 Koninklijke Philips Electronics N.V. Procede et appareil de caracterisation d'interactions de style a clic simple en fonction d'un flux de travail de tache clinique
US20080176318A1 (en) 2006-12-07 2008-07-24 Wilson John R Highly efficient devices and methods for culturing cells
US7897379B2 (en) * 2007-02-26 2011-03-01 Corning Incorporated Device and method for reducing bubble formation in cell culture
US20090160975A1 (en) * 2007-12-19 2009-06-25 Ncr Corporation Methods and Apparatus for Improved Image Processing to Provide Retroactive Image Focusing and Improved Depth of Field in Retail Imaging Systems
AU2009268666B2 (en) * 2008-07-08 2014-11-13 Wilson Wolf Manufacturing, LLC Improved gas permeable cell culture device and method of use
JP6434283B2 (ja) 2014-11-18 2018-12-05 株式会社栗本鐵工所 ラジオコントロール用送信機

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228243A (en) * 1978-07-13 1980-10-14 Toray Industries, Inc. Cell culture propagation apparatus
US4839292A (en) * 1987-09-11 1989-06-13 Cremonese Joseph G Cell culture flask utilizing a membrane barrier
US4839292B1 (en) * 1987-09-11 1994-09-13 Joseph G Cremonese Cell culture flask utilizing membrane barrier
US5693537A (en) * 1994-06-28 1997-12-02 Wilson; John R. Compartmentalized tissue culture flask
US6228607B1 (en) * 1995-04-28 2001-05-08 Organogenesis Inc. Bioreactor

Also Published As

Publication number Publication date
CA2671812A1 (fr) 2008-06-19
EP2092052A4 (fr) 2012-11-14
EP2089507A4 (fr) 2012-12-26
CA2671812C (fr) 2015-06-16
AU2007332869B2 (en) 2012-10-11
US20080227176A1 (en) 2008-09-18
US20140315296A1 (en) 2014-10-23
US20220049215A1 (en) 2022-02-17
EP2089507A2 (fr) 2009-08-19
US9732317B2 (en) 2017-08-15
JP2010512149A (ja) 2010-04-22
WO2008073314A3 (fr) 2008-07-31
AU2007332869A1 (en) 2008-06-19
JP2010512148A (ja) 2010-04-22
WO2008073314A2 (fr) 2008-06-19
US11377635B2 (en) 2022-07-05
EP2092052B1 (fr) 2020-09-23
JP5366820B2 (ja) 2013-12-11
CN101611133A (zh) 2009-12-23
EP3770247A1 (fr) 2021-01-27
WO2008073313A2 (fr) 2008-06-19
CA2671967A1 (fr) 2008-06-19
US20080176318A1 (en) 2008-07-24
US8809044B2 (en) 2014-08-19
US20170313977A1 (en) 2017-11-02
US20210253997A1 (en) 2021-08-19
US20230303967A1 (en) 2023-09-28
EP2092052A2 (fr) 2009-08-26
US20230265383A1 (en) 2023-08-24
CN101611132A (zh) 2009-12-23
AU2007332870A1 (en) 2008-06-19
CN101611132B (zh) 2013-09-11

Similar Documents

Publication Publication Date Title
WO2008073313A3 (fr) Dispositifs perméables au gaz particulièrement efficaces et procédés de culture de cellules
WO2010048417A3 (fr) Bioréacteur à perfusion, systèmes de culture cellulaire et procédés de production de cellules et de produits dérivés de cellule
WO2007002086A3 (fr) Culture en suspension de cellules souches embryonnaires humaines
WO2007098150A3 (fr) Photobioréacteur et son utilisation
EP1788073A4 (fr) Élément de feuille poreuse pour la culture de cellules, bioréacteur et procédé de culture l'utilisant
EP4223769A3 (fr) Facteur de reprogrammation nucléaire
TW200745336A (en) Installation of genomes or partial genomes into cells or cell-like systems
DK2314300T3 (da) Populationer af blandede celler til vævsreparation og separationsteknik til cellebehandling
WO2011018234A3 (fr) Récipient pour cultiver des cellules
MX2011011731A (es) Sistemas, aparatos y metodos para cultivar microorganismos y mitigacion de gases.
EA201270103A1 (ru) Фотобиореакторы, системы аккумулирования солнечной энергии и способы регулирования температуры
WO2009036385A3 (fr) Expression de séquences d'acides nucléiques servant à la production de biocarburants et d'autres produits chez l'algue et les cyanobactéries
MY157374A (en) Method of cell cultures and device for implementing it
SG170761A1 (en) Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
ITFI20030047A1 (it) Reattore per la coltura industriale di microrganismi fotosintetici
UA92157C2 (ru) Способ продуцирования гормона роста
WO2011116922A9 (fr) Substrat thermoréactif comportant des microgels, procédé de fabrication de ce substrat et procédé de culture de cellules biologiques
WO2008104586A3 (fr) Système de culture à grande surface avec un substrat d'augmentation de surface
GB2477698B (en) Methods for conducting cellular assays
CL2011002912A1 (es) Camara de cultivo para cultivo de organismos fotosinteticos que incluye pared o paredes, una o mas entradas de gas y una o mas salidas de gas en comunicacion con el espacio de gas; sistema de camaras; metodo para cultivar organismos fotosinteticos; metodo para conversion de co2 en biomasa de algas; roductos extraidos.
WO2015087169A3 (fr) Bioréacteurs supportés dans un châssis à claies et procédés de culture de micro-organismes les utilisant
WO2009149359A3 (fr) Indice de survie pour un lymphome à grandes cellules b diffus
EP1781082A4 (fr) Systeme biologique de transfert de genes pour cellules eucaryotes
WO2006119054A3 (fr) Procede en plusieurs etapes pour produire une proteine therapeutique
DE602007007944D1 (de) Vorrichtung zur kultivierung von zellen oder mikroorganismen

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780051036.0

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07862656

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2009540319

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2671812

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007862656

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2007332869

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2007332869

Country of ref document: AU

Date of ref document: 20071207

Kind code of ref document: A