WO2008037557A3 - Médicaments anti-inflammatoires non stéroïdiens solubilisés - Google Patents

Médicaments anti-inflammatoires non stéroïdiens solubilisés Download PDF

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Publication number
WO2008037557A3
WO2008037557A3 PCT/EP2007/059079 EP2007059079W WO2008037557A3 WO 2008037557 A3 WO2008037557 A3 WO 2008037557A3 EP 2007059079 W EP2007059079 W EP 2007059079W WO 2008037557 A3 WO2008037557 A3 WO 2008037557A3
Authority
WO
WIPO (PCT)
Prior art keywords
steroidal anti
nsaid
solubilising
formulation
rapidly
Prior art date
Application number
PCT/EP2007/059079
Other languages
English (en)
Other versions
WO2008037557A2 (fr
Inventor
Peter Gruber
Peter Kraahs
Original Assignee
Losan Pharma Gmbh
Peter Gruber
Peter Kraahs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Losan Pharma Gmbh, Peter Gruber, Peter Kraahs filed Critical Losan Pharma Gmbh
Priority to US12/443,446 priority Critical patent/US20100035937A1/en
Priority to BRPI0717279-6A priority patent/BRPI0717279A2/pt
Priority to AU2007302163A priority patent/AU2007302163A1/en
Priority to CA002664773A priority patent/CA2664773A1/fr
Publication of WO2008037557A2 publication Critical patent/WO2008037557A2/fr
Publication of WO2008037557A3 publication Critical patent/WO2008037557A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé de production d'un médicament anti-inflammatoire non stéroïdien (NSAID) solubilisé, lequel procédé comprend les étapes consistant : à se munir d'un mélange contenant un médicament anti-inflammatoire non stéroïdien solide et d'une première base sélectionnée dans un groupe de bases dont le pH est au moins égal à 11 comme solution ou dispersion aqueuse 0,1 molaire; puis à faire réagir ledit médicament anti-inflammatoire non stéroïdien avec la première base à l'état essentiellement sec. Cette invention concerne également un médicament anti-inflammatoire non stéroïdien solubilisé pouvant être obtenu par ce procédé et des compositions pharmaceutiques contenant ce médicament.
PCT/EP2007/059079 2006-09-28 2007-08-30 Médicaments anti-inflammatoires non stéroïdiens solubilisés WO2008037557A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/443,446 US20100035937A1 (en) 2006-09-28 2007-08-30 Solubilized non-steroidal anti-inflammatory drugs
BRPI0717279-6A BRPI0717279A2 (pt) 2006-09-28 2007-08-30 Fármacos anti-inflamatórios não-esteroidais solubilizados.
AU2007302163A AU2007302163A1 (en) 2006-09-28 2007-08-30 Rapidly solubilising formulation of non-steroidal anti-inflammatory drugs
CA002664773A CA2664773A1 (fr) 2006-09-28 2007-08-30 Medicaments anti-inflammatoires non steroidiens solubilises

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06121457.3 2006-09-28
EP06121457A EP1905427B1 (fr) 2006-09-28 2006-09-28 Formulation solubilisée rapidement des anti-inflammatoires non stéroïdiens

Publications (2)

Publication Number Publication Date
WO2008037557A2 WO2008037557A2 (fr) 2008-04-03
WO2008037557A3 true WO2008037557A3 (fr) 2008-07-03

Family

ID=37685214

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/059079 WO2008037557A2 (fr) 2006-09-28 2007-08-30 Médicaments anti-inflammatoires non stéroïdiens solubilisés

Country Status (12)

Country Link
US (1) US20100035937A1 (fr)
EP (1) EP1905427B1 (fr)
CN (1) CN101522175A (fr)
AT (1) ATE489077T1 (fr)
AU (1) AU2007302163A1 (fr)
BR (1) BRPI0717279A2 (fr)
CA (1) CA2664773A1 (fr)
DE (1) DE602006018467D1 (fr)
ES (1) ES2353900T3 (fr)
PL (1) PL1905427T3 (fr)
RU (1) RU2009109071A (fr)
WO (1) WO2008037557A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1863460B1 (fr) 2005-03-22 2013-01-16 Losan Pharma GmbH Ibuprofen solubilisé
EP2608878A4 (fr) 2010-08-23 2017-11-15 President and Fellows of Harvard College Ondes acoustiques en microfluidique
CN103249405A (zh) * 2010-08-23 2013-08-14 哈佛学院院长等 用于药物递送和其他应用的颗粒
JP6194248B2 (ja) * 2010-10-28 2017-09-06 パシラ ファーマシューティカルズ インコーポレーテッド 非ステロイド性抗炎症薬の徐放性処方物
RU2502507C2 (ru) * 2011-09-02 2013-12-27 Людмила Васильевна Безпалько Фармацевтическая композиция с противовоспалительной, кардио- и хондропротекторной активностью, действием против гастропатий, вызываемых нпвп, и способ ее получения
JP2016507542A (ja) 2013-02-08 2016-03-10 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 反応型噴霧乾燥による無機／有機複合材料の製造
US9138381B2 (en) 2013-02-08 2015-09-22 Basf Se Production of inorganic-organic composite materials by reactive spray-drying
US10258987B2 (en) 2014-06-26 2019-04-16 President And Fellows Of Harvard College Fluid infection using acoustic waves
DK3341116T3 (da) 2015-08-27 2022-05-02 Harvard College Sorteringsfremgangsmåde under anvendelse af akustiske bølger
GB2546513B (en) 2016-01-20 2020-09-16 Cubic Pharmaceuticals Ltd Process of preparing active pharmaceutical ingredient salts
CN106361756B (zh) * 2016-08-30 2019-01-15 山东百维药业有限公司 一种氨糖美辛肠溶片及其制备方法
EP3541815A4 (fr) 2016-11-18 2020-07-15 Pacira Pharmaceuticals, Inc. Formulations de liposomes multivésiculaires à microparticules de complexe de méloxicam de zinc et leurs procédés de fabrication
CN106361714A (zh) * 2016-11-24 2017-02-01 江苏中邦制药有限公司 一种含萘普生的药物组合物的制备方法
WO2018111459A1 (fr) * 2016-12-14 2018-06-21 Dow Global Technologies Llc Procédé de génération de sels d'ingrédients pharmaceutiques actifs
CN111494307A (zh) * 2019-01-30 2020-08-07 北京普德康利医药科技发展有限公司 一种氟比洛芬注射液
US11701658B2 (en) 2019-08-09 2023-07-18 President And Fellows Of Harvard College Systems and methods for microfluidic particle selection, encapsulation, and injection using surface acoustic waves

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009988A1 (fr) * 1997-08-27 1999-03-04 Hexal Ag Nouvelles compositions pharmaceutiques de meloxicam presentant une solubilite et une biodisponibilite ameliorees
US5969181A (en) * 1996-06-20 1999-10-19 Breitenbach; Joerg Preparation of salts of pharmaceutical active substances which have acidic groups
WO2000013672A1 (fr) * 1998-09-04 2000-03-16 Elan Pharma International Ltd Nouvelle forme de naproxene nanoparticulaire en dose solide
US6171617B1 (en) * 1996-02-20 2001-01-09 Losan Pharma Gmbh Effervescent ibuprofen preparation and process for the production thereof
WO2001041733A2 (fr) * 1999-12-09 2001-06-14 The Boots Company Plc Agents therapeutiques
EP1800667A1 (fr) * 2005-12-23 2007-06-27 Losan Pharma GmbH Granulate d'ibuprofen solubilisé rapidement

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183829A (en) * 1991-09-27 1993-02-02 Applied Analytical Industries, Inc. Oral liquid compositions of non-steroidal anti-inflammatory drugs
IT1272149B (it) 1993-03-26 1997-06-11 Zambon Spa Composizione farmeceutiche ad attivita' analgesica
AU7637296A (en) 1995-11-14 1997-06-05 Farmarc Nederland Bv Complex of naproxen and beta-cyclodextrin
CA2363528A1 (fr) 2001-11-19 2003-05-19 Merck Patent Gesellschaft Mit Beschraenkter Haftung Pastille a liberation immediate contenant du naproxen sodique
SE0200154D0 (sv) 2002-01-21 2002-01-21 Galenica Ab New process

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171617B1 (en) * 1996-02-20 2001-01-09 Losan Pharma Gmbh Effervescent ibuprofen preparation and process for the production thereof
US5969181A (en) * 1996-06-20 1999-10-19 Breitenbach; Joerg Preparation of salts of pharmaceutical active substances which have acidic groups
WO1999009988A1 (fr) * 1997-08-27 1999-03-04 Hexal Ag Nouvelles compositions pharmaceutiques de meloxicam presentant une solubilite et une biodisponibilite ameliorees
WO2000013672A1 (fr) * 1998-09-04 2000-03-16 Elan Pharma International Ltd Nouvelle forme de naproxene nanoparticulaire en dose solide
WO2001041733A2 (fr) * 1999-12-09 2001-06-14 The Boots Company Plc Agents therapeutiques
EP1800667A1 (fr) * 2005-12-23 2007-06-27 Losan Pharma GmbH Granulate d'ibuprofen solubilisé rapidement

Also Published As

Publication number Publication date
WO2008037557A2 (fr) 2008-04-03
ATE489077T1 (de) 2010-12-15
ES2353900T3 (es) 2011-03-08
CA2664773A1 (fr) 2008-04-03
DE602006018467D1 (de) 2011-01-05
PL1905427T3 (pl) 2011-05-31
CN101522175A (zh) 2009-09-02
AU2007302163A1 (en) 2008-04-03
EP1905427A1 (fr) 2008-04-02
RU2009109071A (ru) 2010-11-10
EP1905427B1 (fr) 2010-11-24
US20100035937A1 (en) 2010-02-11
BRPI0717279A2 (pt) 2013-10-22

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