WO2007077203A3 - Derives de triterpenequinone et de triterpenephenol et leur application pour le traitement de tumeurs et de maladies parasitaires - Google Patents

Derives de triterpenequinone et de triterpenephenol et leur application pour le traitement de tumeurs et de maladies parasitaires Download PDF

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Publication number
WO2007077203A3
WO2007077203A3 PCT/EP2006/070276 EP2006070276W WO2007077203A3 WO 2007077203 A3 WO2007077203 A3 WO 2007077203A3 EP 2006070276 W EP2006070276 W EP 2006070276W WO 2007077203 A3 WO2007077203 A3 WO 2007077203A3
Authority
WO
WIPO (PCT)
Prior art keywords
triterpenequinone
triterpenephenol
tumors
derivatives
treatment
Prior art date
Application number
PCT/EP2006/070276
Other languages
English (en)
Other versions
WO2007077203A2 (fr
Inventor
Sanjuan Juan Carlos Lacal
De Molina Ana Ramirez
Coronel Monica Banez
Ravelo Angel Gutierrez
Braun Ana Estevez
Mesa Siverio Dulce Yazmin
Sacau Elisa Perez
Original Assignee
Consejo Superior Investigacion
Univ La Laguna
Sanjuan Juan Carlos Lacal
De Molina Ana Ramirez
Coronel Monica Banez
Ravelo Angel Gutierrez
Braun Ana Estevez
Mesa Siverio Dulce Yazmin
Sacau Elisa Perez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior Investigacion, Univ La Laguna, Sanjuan Juan Carlos Lacal, De Molina Ana Ramirez, Coronel Monica Banez, Ravelo Angel Gutierrez, Braun Ana Estevez, Mesa Siverio Dulce Yazmin, Sacau Elisa Perez filed Critical Consejo Superior Investigacion
Priority to CA002635318A priority Critical patent/CA2635318A1/fr
Priority to MX2008008556A priority patent/MX2008008556A/es
Priority to AU2006334359A priority patent/AU2006334359A1/en
Priority to JP2008547980A priority patent/JP2009522239A/ja
Priority to BRPI0620845-2A priority patent/BRPI0620845A2/pt
Priority to EP06830856A priority patent/EP1976533A2/fr
Publication of WO2007077203A2 publication Critical patent/WO2007077203A2/fr
Publication of WO2007077203A3 publication Critical patent/WO2007077203A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

La présente invention concerne des dérivés de triterpènequinone et de triterpènephénol, leurs sels promédicaments, solvates ou stéréo-isomères pharmaceutiquement acceptables, en tant qu'agents bloquants sélectifs de l'enzyme choline kinase, des compositions pharmaceutiques les contenant et leur utilisation pour le traitement de tumeurs et de maladies parasitaires ou de maladies causées par des virus, des bactéries ou des champignons.
PCT/EP2006/070276 2005-12-30 2006-12-29 Derives de triterpenequinone et de triterpenephenol et leur application pour le traitement de tumeurs et de maladies parasitaires WO2007077203A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002635318A CA2635318A1 (fr) 2005-12-30 2006-12-29 Derives de triterpenequinone et de triterpenephenol et leur application pour le traitement de tumeurs et de maladies parasitaires
MX2008008556A MX2008008556A (es) 2005-12-30 2006-12-29 Derivados de triterpenoquinonas y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias.
AU2006334359A AU2006334359A1 (en) 2005-12-30 2006-12-29 Triterpenequinone and triterpenephenol derivatives and their application for the treatment of tumors and parasitic diseases
JP2008547980A JP2009522239A (ja) 2005-12-30 2006-12-29 トリテルペンキノンおよびトリテルペンフェノール誘導体、ならびに腫瘍および寄生生物性疾患の治療のためのそれらの適用
BRPI0620845-2A BRPI0620845A2 (pt) 2005-12-30 2006-12-29 derivados de triterpenoquinona e triterpenofenol e sua aplicação para o tratamento de tumores e doenças parasitárias
EP06830856A EP1976533A2 (fr) 2005-12-30 2006-12-29 Derives de triterpenequinone et de triterpenephenol et leur application pour le traitement de tumeurs et de maladies parasitaires

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200503263A ES2277568B1 (es) 2005-12-30 2005-12-30 Derivados de triterpenoquinona y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias.
ESP200503263 2005-12-30

Publications (2)

Publication Number Publication Date
WO2007077203A2 WO2007077203A2 (fr) 2007-07-12
WO2007077203A3 true WO2007077203A3 (fr) 2007-08-30

Family

ID=37946257

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/070276 WO2007077203A2 (fr) 2005-12-30 2006-12-29 Derives de triterpenequinone et de triterpenephenol et leur application pour le traitement de tumeurs et de maladies parasitaires

Country Status (11)

Country Link
EP (1) EP1976533A2 (fr)
JP (1) JP2009522239A (fr)
KR (1) KR20080083044A (fr)
CN (1) CN101351211A (fr)
AU (1) AU2006334359A1 (fr)
BR (1) BRPI0620845A2 (fr)
CA (1) CA2635318A1 (fr)
ES (1) ES2277568B1 (fr)
MX (1) MX2008008556A (fr)
RU (1) RU2008131311A (fr)
WO (1) WO2007077203A2 (fr)

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* Cited by examiner, † Cited by third party
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PT1889920E (pt) 2005-04-13 2010-04-14 Consejo Superior Investigacion Método para a identificação in vitro de compostos para terapia do cancro
WO2009026163A1 (fr) * 2007-08-17 2009-02-26 Burnham Institute For Medical Research Compositions et procédés pour inhiber la croissance et la métastase d'un mélanome
CN101434635B (zh) * 2007-11-16 2012-05-16 上海华拓医药科技发展股份有限公司 一类具抗肿瘤活性的水溶性酚性三萜化合物及其制备方法
US20100068302A1 (en) * 2008-09-17 2010-03-18 Traslational Cancer Drugs Pharma, S.L. Methods and compositions for the treatment of cancer
WO2010049173A1 (fr) * 2008-10-31 2010-05-06 Cenix Bioscience Gmbh Utilisation d’inhibiteurs de kinases hôtes pour traiter les maladies infectieuses
JP2013536203A (ja) * 2010-08-23 2013-09-19 スーチョウ・ニューファーマ・カンパニー・リミテッド 特定の化学成分、組成物および方法
CA3002924A1 (fr) 2015-10-23 2017-04-27 Erx Pharmaceuticals Inc. Analogues de celastrol
CN108026141B (zh) * 2016-07-04 2022-03-29 艾凯奇（厦门）生物科技有限公司 孤儿核受体Nur77的配体及其用途
CN109790164B (zh) 2016-07-25 2022-01-25 内尔维亚诺医疗科学公司 作为胆碱激酶抑制剂的嘌呤和3-去氮杂嘌呤类似物
EP3652177A1 (fr) 2017-07-11 2020-05-20 Nerviano Medical Sciences S.r.l. Dérivés de pyrazolo-quinazoline utilisés en tant qu'inhibiteurs de choline kinase
US20220241214A1 (en) 2019-06-20 2022-08-04 University Of Iowa Research Foundation Nanoparticles comprising quinone w methides and compositions for use
CN113827599A (zh) * 2021-09-23 2021-12-24 天津国际生物医药联合研究院 去甲泽拉木醛在抗登革病毒感染中的潜在应用
CN116023426A (zh) * 2022-12-30 2023-04-28 上海海洋大学 去甲泽拉木醛衍生物及其在制备抗癌药物中的应用

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DE4117854A1 (de) * 1991-05-31 1992-12-03 Wiemann Wolfram Verwendung mindestens eines celastroloids als bestandteil fuer ein arzneimittel zur behandlung von erkrankungen des rheumatoiden formenkreises, insbesondere rheumatismus
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SOTANAPHUN UTHAI ET AL: "ANTIMICROBIAL ACTIVITY AND STABILITY OF TINGENONE DERIVATIVES", PLANTA MEDICA, THIEME, STUTTGART, DE, vol. 65, no. 5, 1999, pages 450 - 452, XP008080303, ISSN: 0032-0943 *
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THIEM, DEBORAH A. ET AL: "Bisnortriterpenes from Salacia madagascariensis", JOURNAL OF NATURAL PRODUCTS , 68(2), 251-254 CODEN: JNPRDF; ISSN: 0163-3864, 30 January 2005 (2005-01-30), XP002439426 *

Also Published As

Publication number Publication date
ES2277568B1 (es) 2008-04-01
JP2009522239A (ja) 2009-06-11
BRPI0620845A2 (pt) 2011-11-22
WO2007077203A2 (fr) 2007-07-12
CA2635318A1 (fr) 2007-07-12
ES2277568A1 (es) 2007-07-01
KR20080083044A (ko) 2008-09-12
MX2008008556A (es) 2008-09-26
AU2006334359A2 (en) 2008-08-07
EP1976533A2 (fr) 2008-10-08
RU2008131311A (ru) 2010-02-10
AU2006334359A1 (en) 2007-07-12
CN101351211A (zh) 2009-01-21

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