WO2006106888A1 - Composition orale destinee a favoriser la defecation contenant de l’huile de patchouli et une fibre alimentaire - Google Patents

Composition orale destinee a favoriser la defecation contenant de l’huile de patchouli et une fibre alimentaire Download PDF

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Publication number
WO2006106888A1
WO2006106888A1 PCT/JP2006/306761 JP2006306761W WO2006106888A1 WO 2006106888 A1 WO2006106888 A1 WO 2006106888A1 JP 2006306761 W JP2006306761 W JP 2006306761W WO 2006106888 A1 WO2006106888 A1 WO 2006106888A1
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Prior art keywords
dietary fiber
constipation
gum
oil
defecation
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PCT/JP2006/306761
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English (en)
Japanese (ja)
Inventor
Naoko Harada
Hideaki Kitagori
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Kobayashi Pharmaceutical Co., Ltd.
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Publication of WO2006106888A1 publication Critical patent/WO2006106888A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/719—Pullulans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/723—Xanthans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/731—Carrageenans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/732—Pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Definitions

  • Oral composition for promoting defecation containing pachiyuri oil and dietary fiber
  • the present invention relates to a composition in which defecation is promoted by ingestion.
  • Constipation is a condition in which stool discharge is difficult or rare.
  • Main constipation for example, functional constipation (acute constipation and various chronic constipation (for example, flaccid constipation, spasm) Constipation, dysphagia, rectal constipation, drug-induced constipation)), organic constipation, intestinal paralytic ileus, constipation associated with congenital gastrointestinal dysfunction, constipation associated with intestinal obstruction are known.
  • IBS bowel syndrome
  • the defecation function is impaired due to a decrease in the defecation reflex function, etc.
  • Many of these disorders are caused by dietary habits, lifestyle, physical activity, and psychological background (such as mental stress and emotional instability).
  • Dietary fiber refers to indigestible polysaccharides and lignin that are not hydrolyzed by human digestive enzymes. They are roughly classified into water-soluble dietary fiber and insoluble dietary fiber according to their solubility in water. Although water-soluble dietary fiber is not degraded by human digestive enzymes, it is hydrolyzed by intestinal bacteria in the lower digestive tract, and the organic acids that are degradation products activate the peristaltic movement of the digestive tract and promote defecation.
  • insoluble food fiber absorbs moisture without being digested and absorbed, expands and passes through the gastrointestinal tract to increase the amount of stool, resulting in physical stimulation of the rectum, strengthening stool, In addition, the stool will be softened to improve bowel movement. Because of this difference in action, water-soluble dietary fibers are generally rectal. Insoluble dietary fiber that is effective against constipation is considered effective against colonic (relaxing) constipation.
  • aromatherapy is applied to arousal, sleep, appetite suppression, appetite promotion, smoke suppression, antiemesis, anti-fainting, aphrodisiac, asexuality, asexuality, etc. It has been attracting attention for its effects such as aging, and some essential oil aromas are known to have an effect on constipation.
  • black pepper, camphor, rose, marjoram, hyssop oil, and rosemary oil are known as fragrances effective for constipation (for example, see Non-Patent Documents 1 and 2).
  • a fragrance composition containing peppermint oil and bergamot oil, clarisage oil, lavender oil, rose oil, camille oil, varnish oil, pine oil or zelanium oil, rosemary oil and clariage oil
  • a fragrance composition which is a mixture of a fragrance composition, clove oil and chamomile oil, is inhaled by a person with constipation, thereby reducing constipation discomfort and showing bowel movements.
  • Non-patent document 1 Practical aromatherapy, by Shirley Price, translated by Taro Takayama, Froglans Journal
  • Non-Patent Document 2 Theory and Practice of Aromatherapy ⁇ Aroma Therapy>, Robert Tisland, Translated by Taro Takayama, Frederance Journal
  • Patent Document 1 Japanese Patent Publication No. 7-57734
  • Patent Document 2 Japanese Patent Laid-Open No. 2003-105371
  • a dietary fiber is to be consumed in an effective amount, a considerably large amount is required. In order to promote smooth defecation and lead a healthy life, it is said that it is necessary to take 20 to 25g of dietary fiber a day. Done It will be necessary to supplement 5-10g. For example, if supplemented in the form of a dextrin tablet (400 mg / tablet, 70% by weight of dietary fiber), about 20-30 tablets are required. Alternatively, the effective amount of low-molecular sodium alginate is said to be about 4g per day, and if this effective amount is taken in the form of tablets (500mgZ tablets, 80% by weight of dietary fiber), about 10 tablets are needed. Furthermore, ingestion of dietary fiber can cause stomach irritation, which is uncomfortable for the user. In addition, the fragrance composition is inconvenient to carry and is inconvenient compared to supplements that often inhale fragrances to non-users.
  • an object of the present invention is to provide an oral composition that promotes defecation and suppresses stomach tension.
  • the present inventor has taken orally ingesting only dietary fiber by orally ingesting a composition containing pachiyuri oil and dietary fiber.
  • the present inventors have found that a defecation promoting action can be obtained with a clearly small amount of dietary fiber, and that stomach ablation caused by the intake of dietary fiber is suppressed, thereby completing the present invention.
  • the present invention provides the following composition.
  • Item 1 An oral defecation-promoting oral composition containing pachiyuri oil and dietary fiber.
  • Item 2 The oral composition for promoting defecation according to Item 1, wherein the content of pachilily oil is 0.0:! To 30 wt%, and the dietary fiber content is 0.1 to 99.99 wt%.
  • Dietary fiber is guar gum, locust bean gum, tamarind gum, tara gum, xanthan gum, dalcomannan, carrageenan, alginic acid or a salt thereof, pectin, collagen, polydextrose, pullulan, gum arabic, carboxymethylcellulose sodium, cenorelose
  • item 1 or 2 which is at least one selected from the group consisting of lignin, chitin, chitosan, hemicenololose, hisenenorelose, microcrystalline cellulose, carboxymethylcellulose, methylcellulose, hydroxymethylcellulose and hydroxyethylcellulose
  • Item 4 The composition according to any one of Items 1 to 3, which is a food.
  • Item 5 The composition according to any one of Items 1 to 3, which is a preventive or therapeutic agent for constipation.
  • the present invention can also include the following food compositions and methods.
  • Item 6. A food composition containing a label indicating that it promotes defecation and contains pachiyuri oil and dietary fiber.
  • Item 7. A method for preventing or treating constipation, characterized by co-administration of pachiyuri oil and dietary fiber.
  • the oral composition for promoting defecation of the present invention is characterized in that it contains a patchy lily oil and dietary fiber.
  • the promotion of defecation includes increasing the number of defecations and the amount of defecation from a state in which the number of defecations and the amount of defecation have decreased from normal, and suppressing the decrease in the number of normal defecations.
  • the oral composition for promoting defecation of the present invention is administered to a person with a tendency to constipation (less than 3 stool weeks), the number of stool increases, and when administered to a normal person who does not tend to have constipation (4 or more stool weeks) Reduce the number of bowel movements (maintain normal bowel movements and prevent constipation). Therefore, the oral composition for promoting defecation of the present invention is also useful for preventing or treating constipation.
  • pachiyuri oil can be obtained, for example, by steam distillation of leaves of Pogostemon cablin Ben th. Belonging to the family Lamiaceae, and is used as a cosmetic or fragrance for stone wall (Kameoka) Hiroshi, Essential Oil Chemistry, 89 (1990). Pogostemon patchouli Pelletier. Var. Snavis
  • Essential oils obtained from Hook, Pogostemon heyneanus Benth. are also included in the pachilili oil, and these essential oils can be used alone or in combination of two or more. Pachiyuri oil obtained from Pogostemon cablin Benth.
  • the blending ratio of patchouli oil in the defecation-promoting composition of the present invention is usually 0.01 to 30% by weight, preferably 0.5 to 10% by weight, more preferably 1 to 5% by weight.
  • dietary fiber is an indigestible polysaccharide or lignin that is not hydrolyzed by human digestive enzymes, a low molecular weight indigestible oligosaccharide, an indigestible sugar alcohole, an indigestible starch. Etc.
  • Dietary fiber includes water-soluble dietary fiber such as guar gum, locust bean gum, tamarind gum, tara gum, xanthan gum, gnole manmann, carrageenan, alginic acid or salts thereof, pectin, collagen, polydextrose, pullulan, gum arabic, sodium carboxymethylcellulose, Cellulose, lignin, chitin, chitosan, hemicellulose, heichicellulose, microcrystalline cellose, canoleboxymethinoresenorelose, methinoresenorelose, hydroxymethinoresenorelose, Examples include insoluble dietary fibers such as hydroxyethyl cellulose, indigestible substances obtained by enzymatic degradation of these, and one of these can be used alone or in combination of two or more.
  • water-soluble dietary fiber such as guar gum, locust bean gum, tamarind gum, tara gum, xanthan gum, gnole manmann, carrageenan, alginic acid or
  • Food fiber is generally obtained by enzymatic treatment of plant raw materials, but may be dietary fiber obtained from animal raw materials.
  • the plant raw material is not particularly limited, and includes cereals, beans, potatoes, vegetables, fruits, seaweeds, moss, wood and the like.
  • Examples of plant raw materials include corn hulls, rice bran, wheat bran, barley bran, hato wheat bran, crow wheat bran, rye bran, oat bran, endo beans, soybeans, beet fiber and the like.
  • dietary fiber can be used alone or in combination of two or more.
  • Preferred dietary fibers are sodium salt, calcium salt, magnesium salt of alginic acid; chitin; chitosan; indigestible substances that can also be used as plant raw materials (particularly indigestible substances obtained from corn), and more preferred dietary fiber Is low molecular weight sodium alginate (molecular weight 40000-60000). Since low molecular weight sodium alginate is more easily hydrolyzed than high molecular weight ones, it can be expected to have a higher defecation effect and can be easily formulated.
  • the proportion of dietary fiber in the defecation promoting composition of the present invention is usually 0.:! To 99.99% by weight, preferably 50 to 99.5% by weight, more preferably 70 to 99% by weight. %.
  • the oral composition for promoting defecation of the present invention can be blended with other ingredients within a range not impairing the effects of the present invention.
  • foods such as health foods, functional foods, foods for specified health use, foods for the sick, etc.), pharmaceutical compositions and the like.
  • the blending amount of the other components can be appropriately selected according to the form of the composition, the amount of food consumed, the taste of the user, and the like.
  • Other ingredients include, for example, natural products, vitamins, fresheners, binders, sweeteners, disintegrants, lubricants, colorants, preservatives, sustained release regulators, surfactants, solubilizers, and wetting agents.
  • An agent or the like can be arbitrarily blended.
  • the oral composition for promoting defecation of the present invention can be produced by a conventional method in the field of oral composition.
  • the food composition can be prepared by a usual method in combination with an edible carrier, a food material, a food additive and the like.
  • the oral composition for promoting defecation of the present invention is a food composition
  • its form is limited.
  • Preferred foods are powders, tablets, granules, tablets, chewable tablets, gums, capsules, soft capsules, troches and juices.
  • the intake of the food of the present invention can be appropriately determined according to the form of the food, the age, weight, sex, intake purpose, etc. of the person who takes it, and is not particularly limited. It can be taken in an amount of about 0.01 to 4 g, preferably about 1 to 3 g per day per adult, once or a few times a day.
  • the oral composition for promoting defecation of the present invention is a pharmaceutical composition
  • excipients fillers, binders, wetting agents, disintegrants, surfactants commonly used for the preparation of pharmaceutical preparations , Lubricants, dispersants, buffers, preservatives, solubilizers, preservatives, flavoring agents, additives such as flavoring agents, stabilizers, etc.
  • Lubricants dispersants
  • buffers preservatives, solubilizers, preservatives
  • flavoring agents additives such as flavoring agents, stabilizers, etc.
  • Various dosage forms suitable for oral administration can be selected as the dosage unit form of the pharmaceutical composition.
  • solid preparations such as tablets, pills, granules, capsules, troches, etc .
  • powder preparations such as powders for internal use, powders for external use, powders; solutions, suspensions, emulsions, syrups, mouth powders, aerosols And liquid preparations such as decoction, dipping agent, and decoction.
  • the pharmaceutical composition of the present invention can be prepared according to a conventional method in the form. The method of administration of the pharmaceutical composition is orally administered depending on various dosage forms, the patient's age, sex and other conditions, the degree of disease, etc., which are not particularly limited.
  • the dosage of the pharmaceutical composition is appropriately selected depending on the form of the preparation, the patient's age, sex and other conditions, the degree of the disease, and the like.
  • the dosage should normally be such that the amount of dietary fiber is: about 10 to 10 g, preferably about 1 to 5 g per adult per day.
  • the pharmaceutical composition can be administered once or several times a day.
  • the present invention may include a food composition having an indication of promoting defecation containing patchouli oil and food fiber. Conditions such as the amount of each component in the composition are as described above. It can be determined according to the food composition.
  • the indication to promote defecation is, for example, an indication that the stomach is in good condition, the intestinal movement is adjusted, and the natural intestinal activity is promoted.
  • the present invention may include a method for preventing or treating constipation, which comprises administering a patchy lily oil and a dietary fiber in combination.
  • the administration method of patchouli oil and dietary fiber is oral administration, and the administration conditions such as the dose and the number of administration can be determined according to the administration conditions of the above pharmaceutical composition.
  • defecation is promoted to those who tend to be constipated, and a decrease in the number of defecations is suppressed for normal subjects, which is effective in preventing or treating constipation.
  • stomach tension associated with dietary fiber intake is suppressed.
  • Example 1 Production of the tablet of the present invention
  • Sodium alginate (500mg / l granule) was tableted with a single tableting machine at a pressure of 30Mpa to produce a tablet with a diameter of 10mm, and then impregnated with pachiyuri essential oil (13mg / l granule). Invention tablet).
  • Comparative Example 1 Production of dietary fiber tablet
  • a tablet was prepared under the same conditions as in Example 1 except that no patchy lily essential oil was added (dietary fiber tablet).
  • Example 1 and Comparative Example 1 The two types of tablets obtained in Example 1 and Comparative Example 1 were administered to humans, and the effect on defecation was tested. Twenty-six subjects (14 normal and 12 constipation) were divided into 2 groups (7 normal and 6 constipation in each group). First, in the first week (non-taking period), each subject was recorded the number of stools, the number of bowel movements, and the volume of bowel movement until the fifth day without administration of tablets, and the sixth and seventh days, which are Saturday and Sunday, were recorded. Without, from the second week (dose period), one group Take a patchy lily oil and a tablet containing sodium alginate (the tablet of the present invention), and another group take a tablet containing sodium alginate (a dietary fiber tablet) 4 times a day before going to bed.
  • the amount was recorded from day 8 to day 12.
  • the amount of defecation was recorded as “0 golf ball” based on the size of the golf ball.
  • the daily amount of patchy liquor oil and sodium alginate is 0.52g and the amount of sodium alginate is 2g per day of the tablets containing the patch of lily oil and sodium alginate (the tablet of the present invention), and the daily dose of tablets containing sodium alginate (dietary fiber tablets)
  • the amount of sodium alginate per dose is 2 g.
  • the effective dose of sodium alginate is 4 g / day.
  • Table 1 In the table, “*” indicates that there is a significant difference from the non-dose period (P 0.05).
  • Tests were carried out under the same administration conditions as in Test Example 1, and from the second week, subjects (32, 16 in each group (8 normal, 8 constipation)) were recorded for the presence or absence of stomach belly. The results are shown in Table 2.
  • the oral composition for promoting defecation of the present invention is useful in the field of prevention or treatment of constipation.

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Abstract

Le problème à résoudre dans le cadre de cette invention consiste à fournir une composition orale qui favorise la défécation et réduit le ballonnement abdominal. La solution proposée consiste à utiliser une composition orale contenant de l’huile de patchouli et une fibre alimentaire, qui permet d’une part d’augmenter la fréquence de défécation d’un sujet enclin à la constipation et d’autre part de réguler la diminution de fréquence de défécation d’un sujet normal non enclin à la constipation (c.-à-d. maintenir la fréquence normale de défécation et prévenir ainsi la constipation), ainsi que de réduire le ballonnement abdominal grâce à la présence de la fibre alimentaire. Parmi les exemples de fibres alimentaires figurent les fibres alimentaires hydrosolubles telles que la gomme de guar, la farine de caroube, la gomme de tamarin, la gomme de tara, la gomme de xanthane, le glucomannan, la carragénine, l’acide alginique et ses sels, la pectine, le collagène, le polydextrose, le pullulane, l’acacia et la carboxyméthylcellulose sodique ainsi que les fibres alimentaires insolubles telles que la cellulose, la lignine, la chitine, le chitosan, l’hémicellulose, l’α-cellulose, la cellulose microcristalline, la carboxyméthylcellulose, la méthylcellulose, l’hydroxyméthylcellulose et l’hydroxyéthylcellulose.
PCT/JP2006/306761 2005-03-30 2006-03-30 Composition orale destinee a favoriser la defecation contenant de l’huile de patchouli et une fibre alimentaire WO2006106888A1 (fr)

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JP2005-100138 2005-03-30
JP2005100138A JP4974473B2 (ja) 2005-03-30 2005-03-30 パチュリー油及び食物繊維を含有する排便促進用経口組成物

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Cited By (3)

* Cited by examiner, † Cited by third party
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CN101917975B (zh) * 2007-12-21 2013-05-08 麦克内尔-Ppc股份有限公司 片剂的制造
JPWO2014163031A1 (ja) * 2013-04-01 2017-02-16 株式会社明治 即効性の整腸剤
CN114568465A (zh) * 2022-03-09 2022-06-03 威海世纪博康海藻有限公司 一种含有海带膳食纤维的饼干及其制备方法和应用

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