WO2006106888A1

WO2006106888A1 - Oral composition for promoting defecation containing patchouli oil and dietary fiber

Info

Publication number: WO2006106888A1
Application number: PCT/JP2006/306761
Authority: WO
Inventors: Naoko Harada; Hideaki Kitagori
Original assignee: Kobayashi Pharmaceutical Co., Ltd.
Priority date: 2005-03-30
Filing date: 2006-03-30
Publication date: 2006-10-12
Also published as: JP4974473B2; JP2006273824A

Abstract

[PROBLEMS] To provide an oral composition which promotes defecation and lessens abdominal distension. [MEANS FOR SOLVING PROBLEMS] By using an oral composition containing patchouli oil and a dietary fiber, the defecation frequency of a subject with a tendency toward constipation can be increased while a decrease in the defecation frequency of a normal subject with no tendency toward constipation can be regulated (i.e., the normal defecation frequency can be sustained and constipation can be prevented) and abdominal distension can be lessened owing to the dietary fiber. Examples of the dietary fiber include water-soluble dietary fibers such as guar gum, locust bean gum, tamarind gum, tara gum, xanthan gum, glucomannan, carrageenan, alginic acid or its salts, pectin, collagen, polydextrose, pullulan, acacia and carboxymethylcellulose sodium and insoluble dietary fibers such as cellulose, lignin, chitin, chitosan, hemicellulose, α-cellulose, microcrystalline cellulose, carboxymethylcellulose, methylcellulose, hydroxymethylcellulose and hydroxyethylcellulose.

Description

Specification

Oral composition for promoting defecation containing pachiyuri oil and dietary fiber

Technical field

[0001] The present invention relates to a composition in which defecation is promoted by ingestion.

Background art

[0002] In recent years, many people are suffering from constipation due to westernization of eating habits, lack of exercise, increased social stress, and the like. Constipation (constipation) is a condition in which stool discharge is difficult or rare. Main constipation, for example, functional constipation (acute constipation and various chronic constipation (for example, flaccid constipation, spasm) Constipation, dysphagia, rectal constipation, drug-induced constipation)), organic constipation, intestinal paralytic ileus, constipation associated with congenital gastrointestinal dysfunction, constipation associated with intestinal obstruction Are known. In normal defecation, stimulation of the rectal mucosa by the contents of the intestine transferred into the rectum is transmitted to the center, creating constipation, and reflexes of bowel / muscle relaxation / contraction (defecation reflex) Constipation may be caused by autonomic dysfunction in the lower gastrointestinal tract, hyperabsorption of water in the intestinal tract, decreased secretion of intestinal mucus, movement disorders, gastrointestinal psychosomatic disorders (for example, irritable bowel syndrome = Irritable

bowel syndrome (IBS), the defecation function is impaired due to a decrease in the defecation reflex function, etc. Many of these disorders are caused by dietary habits, lifestyle, physical activity, and psychological background (such as mental stress and emotional instability).

[0003] Recently, dietary fiber has attracted attention for relieving constipation, and many foods containing dietary fiber are commercially available. Dietary fiber refers to indigestible polysaccharides and lignin that are not hydrolyzed by human digestive enzymes. They are roughly classified into water-soluble dietary fiber and insoluble dietary fiber according to their solubility in water. Although water-soluble dietary fiber is not degraded by human digestive enzymes, it is hydrolyzed by intestinal bacteria in the lower digestive tract, and the organic acids that are degradation products activate the peristaltic movement of the digestive tract and promote defecation. On the other hand, most of the insoluble food fiber absorbs moisture without being digested and absorbed, expands and passes through the gastrointestinal tract to increase the amount of stool, resulting in physical stimulation of the rectum, strengthening stool, In addition, the stool will be softened to improve bowel movement. Because of this difference in action, water-soluble dietary fibers are generally rectal. Insoluble dietary fiber that is effective against constipation is considered effective against colonic (relaxing) constipation.

[0004] On the other hand, aromatherapy is applied to arousal, sleep, appetite suppression, appetite promotion, smoke suppression, antiemesis, anti-fainting, aphrodisiac, asexuality, asexuality, etc. It has been attracting attention for its effects such as aging, and some essential oil aromas are known to have an effect on constipation. For example, black pepper, camphor, rose, marjoram, hyssop oil, and rosemary oil are known as fragrances effective for constipation (for example, see Non-Patent Documents 1 and 2). In addition, for example, a fragrance composition containing peppermint oil and bergamot oil, clarisage oil, lavender oil, rose oil, camille oil, varnish oil, pine oil or zelanium oil, rosemary oil and clariage oil It has been reported that the fragrance of a fragrance composition, which is a mixture of a fragrance composition, clove oil and chamomile oil, is inhaled by a person with constipation, thereby reducing constipation discomfort and showing bowel movements. (For example, see Patent Document 1). In addition, for example, if rats are inhaled with the fragrance of a fragrance composition containing pachilili oil, jasmine oil, sandalwood oil, basil oil, melissa oil, juniper oil, lavender oil or clove oil, the number of stools in more than 50% of individuals It has been reported that the movement of the gastrointestinal tract is promoted when a mouse is inhaled with the fragrance of a fragrance composition containing pachiyuri oil (for example, see Patent Document 2).

Non-patent document 1: Practical aromatherapy, by Shirley Price, translated by Taro Takayama, Froglans Journal

Non-Patent Document 2: Theory and Practice of Aromatherapy <Aroma Therapy>, Robert Tisland, Translated by Taro Takayama, Frederance Journal

Patent Document 1: Japanese Patent Publication No. 7-57734

Patent Document 2: Japanese Patent Laid-Open No. 2003-105371

Disclosure of the invention

Problems to be solved by the invention

[0005] However, if a dietary fiber is to be consumed in an effective amount, a considerably large amount is required. In order to promote smooth defecation and lead a healthy life, it is said that it is necessary to take 20 to 25g of dietary fiber a day. Done It will be necessary to supplement 5-10g. For example, if supplemented in the form of a dextrin tablet (400 mg / tablet, 70% by weight of dietary fiber), about 20-30 tablets are required. Alternatively, the effective amount of low-molecular sodium alginate is said to be about 4g per day, and if this effective amount is taken in the form of tablets (500mgZ tablets, 80% by weight of dietary fiber), about 10 tablets are needed. Furthermore, ingestion of dietary fiber can cause stomach irritation, which is uncomfortable for the user. In addition, the fragrance composition is inconvenient to carry and is inconvenient compared to supplements that often inhale fragrances to non-users.

[0006] Therefore, an object of the present invention is to provide an oral composition that promotes defecation and suppresses stomach tension.

Means for solving the problem

[0007] As a result of intensive studies in view of the above-mentioned problems of the prior art, the present inventor has taken orally ingesting only dietary fiber by orally ingesting a composition containing pachiyuri oil and dietary fiber. In comparison, the present inventors have found that a defecation promoting action can be obtained with a clearly small amount of dietary fiber, and that stomach ablation caused by the intake of dietary fiber is suppressed, thereby completing the present invention.

That is, the present invention provides the following composition.

Item 1. An oral defecation-promoting oral composition containing pachiyuri oil and dietary fiber.

Item 2. The oral composition for promoting defecation according to Item 1, wherein the content of pachilily oil is 0.0:! To 30 wt%, and the dietary fiber content is 0.1 to 99.99 wt%.

Item 3. Dietary fiber is guar gum, locust bean gum, tamarind gum, tara gum, xanthan gum, dalcomannan, carrageenan, alginic acid or a salt thereof, pectin, collagen, polydextrose, pullulan, gum arabic, carboxymethylcellulose sodium, cenorelose In item 1 or 2, which is at least one selected from the group consisting of lignin, chitin, chitosan, hemicenololose, hisenenorelose, microcrystalline cellulose, carboxymethylcellulose, methylcellulose, hydroxymethylcellulose and hydroxyethylcellulose The oral composition for promoting defecation as described.

Item 4. The composition according to any one of Items 1 to 3, which is a food.

Item 5. The composition according to any one of Items 1 to 3, which is a preventive or therapeutic agent for constipation.

The present invention can also include the following food compositions and methods. Item 6. A food composition containing a label indicating that it promotes defecation and contains pachiyuri oil and dietary fiber. Item 7. A method for preventing or treating constipation, characterized by co-administration of pachiyuri oil and dietary fiber.

[0009] The oral composition for promoting defecation of the present invention is characterized in that it contains a patchy lily oil and dietary fiber. The promotion of defecation includes increasing the number of defecations and the amount of defecation from a state in which the number of defecations and the amount of defecation have decreased from normal, and suppressing the decrease in the number of normal defecations. When the oral composition for promoting defecation of the present invention is administered to a person with a tendency to constipation (less than 3 stool weeks), the number of stool increases, and when administered to a normal person who does not tend to have constipation (4 or more stool weeks) Reduce the number of bowel movements (maintain normal bowel movements and prevent constipation). Therefore, the oral composition for promoting defecation of the present invention is also useful for preventing or treating constipation.

[0010] In the present invention, pachiyuri oil can be obtained, for example, by steam distillation of leaves of Pogostemon cablin Ben th. Belonging to the family Lamiaceae, and is used as a cosmetic or fragrance for stone wall (Kameoka) Hiroshi, Essential Oil Chemistry, 89 (1990). Pogostemon patchouli Pelletier. Var. Snavis

Essential oils obtained from Hook, Pogostemon heyneanus Benth. Are also included in the pachilili oil, and these essential oils can be used alone or in combination of two or more. Pachiyuri oil obtained from Pogostemon cablin Benth. The blending ratio of patchouli oil in the defecation-promoting composition of the present invention is usually 0.01 to 30% by weight, preferably 0.5 to 10% by weight, more preferably 1 to 5% by weight.

[0011] In the present invention, dietary fiber is an indigestible polysaccharide or lignin that is not hydrolyzed by human digestive enzymes, a low molecular weight indigestible oligosaccharide, an indigestible sugar alcohole, an indigestible starch. Etc. Dietary fiber includes water-soluble dietary fiber such as guar gum, locust bean gum, tamarind gum, tara gum, xanthan gum, gnole manmann, carrageenan, alginic acid or salts thereof, pectin, collagen, polydextrose, pullulan, gum arabic, sodium carboxymethylcellulose, Cellulose, lignin, chitin, chitosan, hemicellulose, heichicellulose, microcrystalline cellose, canoleboxymethinoresenorelose, methinoresenorelose, hydroxymethinoresenorelose, Examples include insoluble dietary fibers such as hydroxyethyl cellulose, indigestible substances obtained by enzymatic degradation of these, and one of these can be used alone or in combination of two or more.

[0012] Food fiber is generally obtained by enzymatic treatment of plant raw materials, but may be dietary fiber obtained from animal raw materials. The plant raw material is not particularly limited, and includes cereals, beans, potatoes, vegetables, fruits, seaweeds, moss, wood and the like. Examples of plant raw materials include corn hulls, rice bran, wheat bran, barley bran, hato wheat bran, crow wheat bran, rye bran, oat bran, endo beans, soybeans, beet fiber and the like. In the present invention, dietary fiber can be used alone or in combination of two or more. Preferred dietary fibers are sodium salt, calcium salt, magnesium salt of alginic acid; chitin; chitosan; indigestible substances that can also be used as plant raw materials (particularly indigestible substances obtained from corn), and more preferred dietary fiber Is low molecular weight sodium alginate (molecular weight 40000-60000). Since low molecular weight sodium alginate is more easily hydrolyzed than high molecular weight ones, it can be expected to have a higher defecation effect and can be easily formulated.

[0013] The proportion of dietary fiber in the defecation promoting composition of the present invention is usually 0.:! To 99.99% by weight, preferably 50 to 99.5% by weight, more preferably 70 to 99% by weight. %.

[0014] If necessary, the oral composition for promoting defecation of the present invention can be blended with other ingredients within a range not impairing the effects of the present invention. And foods such as health foods, functional foods, foods for specified health use, foods for the sick, etc.), pharmaceutical compositions and the like. The blending amount of the other components can be appropriately selected according to the form of the composition, the amount of food consumed, the taste of the user, and the like. Other ingredients include, for example, natural products, vitamins, fresheners, binders, sweeteners, disintegrants, lubricants, colorants, preservatives, sustained release regulators, surfactants, solubilizers, and wetting agents. An agent or the like can be arbitrarily blended.

[0015] The oral composition for promoting defecation of the present invention can be produced by a conventional method in the field of oral composition. For example, the food composition can be prepared by a usual method in combination with an edible carrier, a food material, a food additive and the like.

[0016] When the oral composition for promoting defecation of the present invention is a food composition, its form is limited. For example, powder, tablet ij, granule, tablet, chewable tablet, gum, capsule, soft capsule, troche, rice cake, candy, jelly, biscuit, gummy, rice cracker, bun, cake, bread, potatoes, etc. It can be used as a solid or semi-solid food; liquid drinks such as juice and vegetable / fruit mixed drinks; seasoned foods such as sauce, dressing, sauce, and soy sauce; food additives. Preferred foods are powders, tablets, granules, tablets, chewable tablets, gums, capsules, soft capsules, troches and juices.

[0017] The intake of the food of the present invention can be appropriately determined according to the form of the food, the age, weight, sex, intake purpose, etc. of the person who takes it, and is not particularly limited. It can be taken in an amount of about 0.01 to 4 g, preferably about 1 to 3 g per day per adult, once or a few times a day.

[0018] When the oral composition for promoting defecation of the present invention is a pharmaceutical composition, excipients, fillers, binders, wetting agents, disintegrants, surfactants commonly used for the preparation of pharmaceutical preparations , Lubricants, dispersants, buffers, preservatives, solubilizers, preservatives, flavoring agents, additives such as flavoring agents, stabilizers, etc. These blending amounts are not particularly limited as long as the desired effects are not hindered, and can be appropriately set according to the kind of additive, the dosage form of the pharmaceutical composition, and the like. Various dosage forms suitable for oral administration can be selected as the dosage unit form of the pharmaceutical composition. For example, solid preparations such as tablets, pills, granules, capsules, troches, etc .; powder preparations such as powders for internal use, powders for external use, powders; solutions, suspensions, emulsions, syrups, mouth powders, aerosols And liquid preparations such as decoction, dipping agent, and decoction. The pharmaceutical composition of the present invention can be prepared according to a conventional method in the form. The method of administration of the pharmaceutical composition is orally administered depending on various dosage forms, the patient's age, sex and other conditions, the degree of disease, etc., which are not particularly limited. The dosage of the pharmaceutical composition is appropriately selected depending on the form of the preparation, the patient's age, sex and other conditions, the degree of the disease, and the like. The dosage should normally be such that the amount of dietary fiber is: about 10 to 10 g, preferably about 1 to 5 g per adult per day. The pharmaceutical composition can be administered once or several times a day.

[0019] In addition, the present invention may include a food composition having an indication of promoting defecation containing patchouli oil and food fiber. Conditions such as the amount of each component in the composition are as described above. It can be determined according to the food composition. In addition, the indication to promote defecation is, for example, an indication that the stomach is in good condition, the intestinal movement is adjusted, and the natural intestinal activity is promoted.

[0020] Further, the present invention may include a method for preventing or treating constipation, which comprises administering a patchy lily oil and a dietary fiber in combination. In this method, the administration method of patchouli oil and dietary fiber is oral administration, and the administration conditions such as the dose and the number of administration can be determined according to the administration conditions of the above pharmaceutical composition.

The invention's effect

[0021] According to the present invention, defecation is promoted to those who tend to be constipated, and a decrease in the number of defecations is suppressed for normal subjects, which is effective in preventing or treating constipation. In addition, stomach tension associated with dietary fiber intake is suppressed.

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the present invention will be described in more detail with reference to examples and the like, but the present invention is not limited thereto.

Example

[0023] Example 1: Production of the tablet of the present invention

Sodium alginate (500mg / l granule) was tableted with a single tableting machine at a pressure of 30Mpa to produce a tablet with a diameter of 10mm, and then impregnated with pachiyuri essential oil (13mg / l granule). Invention tablet).

[0024] Comparative Example 1: Production of dietary fiber tablet

A tablet was prepared under the same conditions as in Example 1 except that no patchy lily essential oil was added (dietary fiber tablet).

[0025] Trial, Trial row 1: Sound on flight

The two types of tablets obtained in Example 1 and Comparative Example 1 were administered to humans, and the effect on defecation was tested. Twenty-six subjects (14 normal and 12 constipation) were divided into 2 groups (7 normal and 6 constipation in each group). First, in the first week (non-taking period), each subject was recorded the number of stools, the number of bowel movements, and the volume of bowel movement until the fifth day without administration of tablets, and the sixth and seventh days, which are Saturday and Sunday, were recorded. Without, from the second week (dose period), one group Take a patchy lily oil and a tablet containing sodium alginate (the tablet of the present invention), and another group take a tablet containing sodium alginate (a dietary fiber tablet) 4 times a day before going to bed. The amount was recorded from day 8 to day 12. The amount of defecation was recorded as “0 golf ball” based on the size of the golf ball. The daily amount of patchy liquor oil and sodium alginate is 0.52g and the amount of sodium alginate is 2g per day of the tablets containing the patch of lily oil and sodium alginate (the tablet of the present invention), and the daily dose of tablets containing sodium alginate (dietary fiber tablets) The amount of sodium alginate per dose is 2 g. The effective dose of sodium alginate is 4 g / day. The results are shown in Table 1. In the table, “*” indicates that there is a significant difference from the non-dose period (P 0.05).

[table 1]

[0027] In the tablet of the present invention using sodium alginate in combination with patchouli oil, the number of constipation, the number of stool and the amount of stool increased in the constipation-prone and the whole group, and there was no significant difference in the normal. In the dietary fiber tablets that did not use sodium alginate and patchouli oil, there was no significant difference in each item among normal subjects, those with a tendency to constipation, and the entire group.

[0028] Test Example 2: Belly beam

Tests were carried out under the same administration conditions as in Test Example 1, and from the second week, subjects (32, 16 in each group (8 normal, 8 constipation)) were recorded for the presence or absence of stomach belly. The results are shown in Table 2.

[0029] [Table 2] Tablets of the present invention, dietary fiber, tablets

Normal person Constipated person Normal person Constipated person

Stomach belly

1 1 4 4

Number of people recorded [0030] Eight people (half) complained of stomach pain in dietary fiber tablets that did not use sodium alginate and patchouli mono oil, whereas in the tablet of the present invention that combined sodium alginate and patchouli oil, Two people complained of a stomach belly, suggesting that the combination of patchouli oil can suppress the stomach belly caused by dietary fiber.

Industrial applicability

[0031] The oral composition for promoting defecation of the present invention is useful in the field of prevention or treatment of constipation.

Claims

The scope of the claims

[1] An oral composition for promoting defecation, comprising pachiyuri oil and dietary fiber.

[2] The oral composition for promoting defecation according to claim 1, wherein the content of patchouli oil is 0.0:! To 30% by weight and the dietary fiber content is 0.1-99.99% by weight.

[3] Dietary fiber is guar gum, locust bean gum, tamarind gum, tara gum, xanthan gum, darcomannan, carrageenan, alginic acid or salts thereof, pectin, collagen, polydextrose, punoreran, gum arabic, carboxymethylcellulose sodium Cellulose, cellulose, lignin, chitin, chitosan, hemicellulose, α-cellulose, microcrystalline cellulose, carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, and hydroxyethylcellulose strength are at least one selected The oral composition for promoting defecation according to claim 1 or 2.

[4] The composition according to any one of claims 1 to 3, which is a food.

5. The composition according to any one of claims 1 to 3, which is an agent for preventing or treating constipation.