WO2005092257A1 - Feuille de refroidissement et recipient de refroidissement - Google Patents

Feuille de refroidissement et recipient de refroidissement Download PDF

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Publication number
WO2005092257A1
WO2005092257A1 PCT/JP2005/005479 JP2005005479W WO2005092257A1 WO 2005092257 A1 WO2005092257 A1 WO 2005092257A1 JP 2005005479 W JP2005005479 W JP 2005005479W WO 2005092257 A1 WO2005092257 A1 WO 2005092257A1
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WO
WIPO (PCT)
Prior art keywords
space
cooling
substance
container
lid
Prior art date
Application number
PCT/JP2005/005479
Other languages
English (en)
Japanese (ja)
Inventor
Takeo Ishii
Masahiro Inazuki
Original Assignee
Terumo Kabushiki Kaisha
Teikoku Seiyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Kabushiki Kaisha, Teikoku Seiyaku Co., Ltd. filed Critical Terumo Kabushiki Kaisha
Priority to JP2006511516A priority Critical patent/JP4945238B2/ja
Publication of WO2005092257A1 publication Critical patent/WO2005092257A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/10—Cooling bags, e.g. ice-bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261—Flexible containers having several compartments
    • B65D81/3266—Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0001—Body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0268—Compresses or poultices for effecting heating or cooling having a plurality of compartments being filled with a heat carrier
    • A61F2007/0276—Compresses or poultices for effecting heating or cooling having a plurality of compartments being filled with a heat carrier with separate compartments connectable by rupturing a wall or membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0282—Compresses or poultices for effecting heating or cooling for particular medical treatments or effects
    • A61F2007/0285—Local anaesthetic effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/10—Cooling bags, e.g. ice-bags
    • A61F7/106—Cooling bags, e.g. ice-bags self-cooling, e.g. using a chemical reaction

Definitions

  • the present invention relates to a cooling sheet, and more particularly, to a cooling sheet and a cooling container that can relieve pain during puncturing.
  • one of the indispensable acts for performing a medical practice is the practice of puncturing a patient with an injection needle or the like.
  • Such actions include, for example, puncture of a venous indwelling needle, puncture for various anesthesia such as epidural anesthesia and spinal anesthesia, puncture for a nerve block, and puncture for vaccination of children.
  • a tape preparation containing a local anesthetic is known (see, for example, JP-A-2000-319168). ;). Apply a powerful tape to the site to be punctured prior to puncturing, and paralyze the pain at the site to be punctured by the anesthetic effect of the local anesthetic. Thereby, when puncturing is performed at the site to be punctured, pain at the punctured site at the time of puncturing is alleviated.
  • the tape preparation disclosed in Japanese Patent Application Laid-Open No. 2000-319168 can obtain its effect (effect) unless a local anesthetic is penetrated subcutaneously in a state where the tape preparation is applied to a site to be punctured. Therefore, it is difficult to achieve the effect in a short time. For example, to obtain a sufficient anesthetic effect, that is, a pain relieving effect, it is necessary to apply for 2-3 hours before puncturing.
  • An object of the present invention is to provide a cooling sheet and a cooling container that can easily relieve pain (pain), for example, during puncturing.
  • a bag body having a first space and a second space which are isolated from each other and can communicate with each other when necessary
  • a first substance stored in the first space A first substance stored in the first space
  • the cooling sheet wherein the bag body is bent to form a partition portion, and the partition portion separates the first space and the second space from each other.
  • the partition portion is sandwiched by a sandwiching member, thereby improving the adhesion between inner surfaces of the partition portion, and the first space and the second space.
  • the first pressure-sensitive adhesive layer is provided on both outer surfaces facing each other in a state where the bag is bent, and the drug in one pressure-sensitive adhesive layer contains a hemostatic agent.
  • the cooling sheet according to any one of (10) to (10).
  • the first pressure-sensitive adhesive layer has an area of 10-40 cm 2 in plan view as in (1) above!
  • the cooling device according to any one of (1) to (19), further including a fixing member for fixing the ends of the bag body in a state where the bag body is bent. Sheet.
  • a container including a container main body and a lid displaceably mounted on the container main body; and a space defined by the container main body and the lid, A partition for isolating the space from the first space and the second space on the container body side;
  • a first substance stored in the first space A first substance stored in the first space
  • a cooling container comprising: a release member capable of releasing a state of separation between the first space and the second space by the partition by performing an operation of displacing the partition.
  • the release member is formed of a needle body or a blade
  • the release member and the rupturable sheet are made to approach each other, and the rupturable sheet is ruptured. ).
  • the lid has elasticity
  • the release member is formed of a needle body
  • the above-mentioned (22) is configured such that by pressing the lid toward the container body, the release member and the easily rupturable sheet are brought close to each other to rupture the easily rupturable sheet. Cooling vessel.
  • the cooling container according to any one of (21) to (37), which is capable of being held for a while.
  • the site to be punctured can be cooled prior to puncture and an excellent pain relieving effect can be exhibited, so that pain at the time of puncture can be easily alleviated.
  • the target portion can be efficiently cooled. For this reason, for example, by cooling the site to be punctured on the surface of the living body prior to puncturing with an injection needle or the like, pain at the time of puncturing can be remarkably effectively reduced. [0050] Further, by providing the pressure-sensitive adhesive layer, the pressure-sensitive adhesive layer can be fixed to a target portion, and the portion can be cooled more easily and reliably.
  • FIG. 1 is a plan view (internal transmission diagram) showing a first embodiment of a cooling sheet of the present invention
  • FIG. 2 is a sectional view taken along line AA in FIG. 1
  • FIG. FIG. 4 is a plan view showing a state in which the cooling sheet is expanded
  • FIG. 4 is a view showing a use state of the cooling sheet in FIG. 1 in a cross section corresponding to FIG.
  • the upper side in FIG. 1 is referred to as “upper”, the lower side as “lower”, the upper side in FIG. 2 as “upper”, the lower side as “lower”, and the upper side in FIG. 3 as “upper”.
  • the lower side is described as “bottom”, the left side in FIG. 4 is described as “upper”, and the right side is described as “lower”.
  • the cooling sheet 1 is composed of a bag 2 containing two kinds of substances, a first pressure-sensitive adhesive layer 3 provided on the outer surface of the bag 2 and a second pressure-sensitive adhesive. And layer 4.
  • cooling sheet 1 Prior to puncturing the surface of a living body (hereinafter, referred to as “skin”), cooling sheet 1 is applied to the skin so as to cover the site to be punctured with first adhesive layer 3 and the surrounding area. It is used by wearing (wearing) to cool the site to be punctured. Thereby, pain (pain) at the time of puncturing can be reduced.
  • the bag 2 is formed by sealing a sheet material described later in a desired pattern by fusing (or bonding). Thus, a band-shaped seal portion 20 is formed on the outer peripheral portion of the bag body 2 and the like.
  • the bag body 2 is folded into two substantially at the center from the state shown in Fig. 3 to form a partition portion 23.
  • Figs. The situation is as shown in Fig. 2.
  • the inside of the bag 2 is divided into two by the partitioning portion 23 as shown in FIG. 2, and is divided into the adjacent first space 21 and second space 22.
  • a first space 21 is formed on the left side in FIG. 2
  • a second space 22 is formed on the right side.
  • These spaces are mutually separated by a partition (bent portion) 23 formed by the bending. Isolated.
  • the above-mentioned seal portion 20 has a width t at the partition portion 23 and the vicinity thereof and a force t wider than the width t of the other portions.
  • the partition 23 has a width t at the partition portion 23 and the vicinity thereof and a force t wider than the width t of the other portions.
  • the adhesive strength in the partition portion 23 and the vicinity thereof is higher than that of the other portions. According to this, similarly to the above, the breakage of the seal portion 20 can be prevented.
  • the partition 23 is formed by bending the bag body 2 upward and downward at a first bent portion 23A, which is a substantially central portion, from the state shown in FIG. Thereby, the partitioning section 23 partitions the internal space of the bag body 2 into the adjacent first space 21 and second space 22.
  • These division states depend on the substances (the first substance and the second substance) contained in the first space 21 and the second space 22, but are preferably liquid-tight or air-tight.
  • the lower portion of the bag body 2 in FIGS. 1 and 2 is double-folded at the first bent portion 23A and the second bent portion 23B to form the partition portion 23. Is formed.
  • the airtightness (liquid tightness) between the first space 21 and the second space 22 is improved, and the first space 21 and the second space 22 are not used (before use). Unintended communication with the space 22 of the second space is prevented.
  • the partition 23 may be formed by simply bending the bag 2 once at the first bent portion 23A, or by bending the bag 2 three or more times. It may be formed by. For example, as shown in FIG. 5, the lower portion of the bag body 2 is triple-folded at the first bent portion 23A, the second bent portion 23B, and the third bent portion 23C (folded). T), a partition can be formed. Thereby, the airtightness (liquid tightness) between the first space 21 and the second space 22 is further improved, and the first space 21 and the second space 21 are not used (before use). Inadvertent communication with 22 is more reliably prevented.
  • Fig. 5 shows the bag 2 It is an expanded sectional view showing other examples of a partition.
  • the opposing inner surfaces of the bag body 2 may be supplementarily sealed by a weak seal or the like. Such an auxiliary seal is easily broken by hitting the bag body 2 or the like, so that the first space 21 and the second space 22 can communicate with each other.
  • the bag 2 is changed from the state shown in Fig. 1 and Fig. 2 to the state shown in Fig. 3 so that the separation by the partitioning part 23 is released and the first space is released. 21 communicates with the second space 22.
  • such a bag body 2 can be again placed in the isolated state after the first space 21 and the second space 22 are in communication with each other. That is, communication and isolation between the first space 21 and the second space 22 are performed reversibly.
  • the first space 21 contains the first substance 5
  • the second space 22 contains the second substance 6.
  • the first substance 5 and the second substance 6 cause an endothermic reaction when they come into contact with each other.
  • the present invention uses this endothermic reaction as a cooling means to cool the site to be punctured.
  • the cooling sheet 1 is preferably capable of maintaining the temperature of the skin (the site to be punctured) at 5 ° C to 20 ° C for 5 minutes or more by an endothermic reaction. — More preferred is one that can be held at 18 ° C for more than 7 minutes. By satisfying such conditions, the site to be punctured can be effectively cooled, and the pain caused by puncturing can be effectively alleviated even after the cooling sheet 1 is peeled off from the site to be punctured.
  • the cooling temperature is too low, the site to be punctured may be excessively cooled, causing frostbite, and excessive cooling may cause pain. On the other hand, if the cooling temperature is too high, there is a possibility that the pain relieving effect at the time of puncturing cannot be sufficiently obtained.
  • the duration (retention time) is too short, the site to be punctured is not sufficiently cooled, and In some cases, the pain relief effect at the time of sting cannot be sufficiently obtained.
  • the first substance (water solution) 5 is not particularly limited as long as it causes an endothermic reaction upon contact with the second substance 6, and in addition to water, for example, microcapsule squirt water or , Sodium carbonate 10 hydrate, sodium sulfate 10 hydrate, sodium phosphate 12 hydrate, sodium hydrogen phosphate 12 hydrate, sodium sulfite heptahydrate, sodium silicate nonahydrate, tetraborate Sodium 10 hydrate, aluminum sulfate 18 hydrate, aluminum nitrate 9 hydrate, calcium chloride 6 hydrate, barium hydroxide octahydrate, chromium nitrate 9 hydrate, iron (III) nitrate 9 hydrate And hydrated compounds, and one or more of these can be used in combination.
  • the first substance 5 is more preferably a substance mainly composed of barium hydroxide octahydrate, which is preferably a substance mainly composed of water and barium hydroxide octahydrate.
  • the form of the first substance 5 may be, for example, any of liquid, solid, and gel.
  • the space between the first space 21 and the second space 22 need not be completely sealed (airtight).
  • undesired reaction between the first substance 5 and the second substance 6 can be prevented.
  • the first substance 5 when a solid, gel, or the like is used as the first substance 5, if the first substance 5 is formed into a powder, flake, or small lump (pellet), The mixing with the substance 6 of 2 becomes easy, and the dissolution rate can be increased. As a result, the cooling effect can be achieved in a shorter time. From this point, it is particularly preferable to make the first substance 5 into a powder form.
  • the average particle size is not particularly limited, but is preferably 1 ⁇ m to 3 mm, more preferably 50 m to 1 mm.
  • the average particle size of the first substance 5 is less than the lower limit, the scattering property is increased, and the adjustment becomes complicated.
  • the average particle size of the first substance 5 exceeds the upper limit, the mixing property with the second substance 6 becomes low, and a sufficient cooling effect (pain alleviation effect) cannot be obtained, It takes a long time from when the cooling sheet is applied to when the pain relief effect can be expected, and immediate effect is expected Or not.
  • the second substance (cryogen) 6 is not particularly limited as long as it gives an endothermic reaction upon contact with the first substance 5, and examples thereof include ammonium nitrate, potassium nitrate, sodium nitrate, and the like.
  • the second substance 6 is, in particular, ammonium nitrate. Preference is given to those containing ammonium, ammonium chloride and ammonium thiocyanate as the main components, while those containing ammonium nitrate as the main component are more preferable. By using the powerful second substance 6, a cooling effect can be exhibited in a shorter time.
  • the form (shape) of the second substance 6 may be any solid such as powder, flakes, small lumps (pellets), etc. It is preferable to use a powder. This facilitates the mixing with the first substance 5 and increases the dissolution rate, and as a result, the cooling effect can be exhibited in a shorter time.
  • the average particle size is not particularly limited, but is preferably: Lm-3mm, more preferably 50m-lmm. preferable.
  • the average particle size of the second substance 6 is less than the lower limit, the scattering property is increased and the adjustment becomes complicated.
  • the average particle size of the second substance 6 exceeds the upper limit, the mixing property with the first substance 5 is reduced, and a sufficient cooling effect (pain alleviation effect) is not obtained. After applying the cooling sheet, it may take a long time until the pain relief effect can be expected, I can not expect it.
  • the first substance 5 and the second substance 6 may contain a gelling agent, a polymer, or the like for the purpose of, for example, improving the usability or obtaining a sustained cooling effect. May be added.
  • the gelling agent is not particularly limited, but, for example, a crosslinked polymer having a repeating unit of an amide-based compound as a main repeating unit is suitably used.
  • amide compound examples include N-bulformamide, N-bulacetoamide
  • the polymer is not particularly limited !, but, for example, gum arabic, tragacanth gum, locust bean gum, guar gum, echo gum, karaya gum, agar, starch, power lagenan, alginic acid, alginate (eg, alginic acid) Sodium), natural polymers such as propylene glycol alginate, dextran, dextrin, amylose, gelatin, collagen, pullulan, pectin, amylopectin, starch, sodium amylopectin semiglycolate, chitin, albumin, casein , Polyglutamic acid, polyaspartic acid, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylstarch, carboxymethylstarch, alkali metal carboxymethylcellulose, alkali metal cell Semi-synthetic polymers such as cellulose sulfate, cellulose rough polymer, crosslinked gelatin, cellulose acetate phthalate
  • the bag 2 (preferably the entire bag 2) preferably has a steam barrier property.
  • the steam nobility means that the water vapor permeability is preferably 30 gZm 2 '24 hrs' 25 ⁇ m thickness '40 ° C '90% RH or less, more preferably 10 8 ! 11 2 ' 25 ⁇ m
  • Examples of the combination of the first substance 5 and the second substance 6 include a combination of a liquid solid, a solid solid, and a gel solid. Among them, the solid is most preferably a powder.
  • the amount of the first substance 5 filled in the first space 21 may be filled in the entire first space 21 or may be partially filled.
  • the amount of the second substance 6 filled in the second space 22 may be such that the second space 22 can be entirely or partially filled.
  • the amounts of the first substance and the second substance can be increased, so that the cooling effect can be increased or maintained for a long time.
  • the first substance and the second substance are easily mixed and rapid cooling is possible.
  • the bag 2 has the steam barrier property as described above, when water vapor enters the inside of the bag 2 or when the first substance 5 is mainly composed of water, Evaporation of moisture from the first space 21 can be prevented.
  • the first substance 5 when a substance containing water as a main component is used as the first substance 5, it is possible to prevent the reduction and concentration of the first substance 5, and to keep the amount of the first substance 5 to a minimum necessary amount. Thus, the volume and mass of the entire cooling seat can be reduced. In addition, the invasion of water vapor into the second space 22 from the outside of the bag body 2 can be prevented.
  • a sheet material (film) constituting the bag body 2, particularly a sheet material having the above-mentioned water vapor barrier property, is flexible and has sufficient strength, as long as a substance contained therein does not leak.
  • styrene resins eg, polystyrene, butadiene styrene copolymer, acrylonitrile styrene copolymer, acrylonitrile Butadiene styrene copolymer, etc.
  • ABS resin eg, polystyrene resin, butadiene styrene copolymer, acrylonitrile styrene copolymer, acrylonitrile Butadiene styrene copolymer, etc.
  • ABS resin eg, polystyrene resin, butadiene styrene copolymer, acrylonitrile styrene copolymer, acrylonitrile Butadiene sty
  • metal foils such as aluminum films, aluminum-laminate laminate films, or films containing metal foils. Can be used. Further, a laminate of two or more of these films may be used. Thereby, the flexibility and the like of the bag body 2 can be improved.
  • a sheet material it is preferable to select a sheet material having excellent flexibility even at a low temperature. Furthermore, it is preferable to select a material that has heat sealing properties and can be easily fused (heat fusion, ultrasonic fusion, high-frequency fusion).
  • the thickness of the sheet material (single-layer or multi-layer laminate) forming the bag 2 depends on the layer configuration and the characteristics (flexibility, strength, water vapor permeability, heat resistance, etc.) of the material used. Although it is not particularly limited, it is usually preferably about 10 to 1000 m, more preferably about 60 to 700 ⁇ m, more preferably about 100 to 500 ⁇ m. It is even more preferable that
  • the sheet material constituting such a bag body 2 is prepared by, for example, an inflation method, a T-die method, a blow molding method, a dry lamination method, a hot melt lamination method, a co-extrusion inflation method, a co-extrusion T-die method, It can be manufactured by various methods such as a hot press method.
  • the shape of the bag 2 in plan view is not particularly limited and can be appropriately set according to various purposes. In addition to the square (substantially square) as shown in FIG. (Substantially rectangular), circular, oval and the like.
  • the length of one side is preferable.
  • the diameter is preferably about 35 to 71 mm.
  • the first pressure-sensitive adhesive layer 3 is fixed (fixed) by, for example, adhesion using a fusion bonding adhesive.
  • the first pressure-sensitive adhesive layer 3 has a function of fixing the cooling sheet 1 to the skin during use. This prevents the cooling sheet 1 from unintentionally separating from the skin during use.
  • the first pressure-sensitive adhesive layer 3 has reached the lowermost part of one of the opposed outer surfaces of the bag 2 in FIG. That is, the first pressure-sensitive adhesive layer 3 is formed not only on the outer surface of one of the opposed outer surfaces of the bag body 2 but also on the partition corresponding to the first space 21 and the second space 22. It reaches the part corresponding to part 23. As a result, the partition 23 is securely held in a bent state when not used (before use).
  • the means for holding the partition portion 23 in a bent state is achieved by bonding or fusing a part of the opposing surfaces in the bent portion (the partition portion 23) of the bag body 2.
  • the invention is not limited to the above-described one as long as the state of separation between the first space 21 and the second space 22 is maintained.
  • adheresion refers to a state in which two surfaces are bonded together by chemical or physical force or both using an adhesive as a medium, and a strong force at room temperature without using heat or a solvent. It refers to a concept that includes "adhesion” which is in a bonded state by being added.
  • Fusion refers to a state in which the materials themselves are fused and bonded.
  • an adhesive or an adhesive to the outer surface on the right side, it is also possible to hold the partition 23 in a folded state.
  • the adhesion and the fusion are of such a degree that they can be easily released (weak adhesion or weak seal). That is, it is preferable that the bonding or the fusion be performed so that the folded state is released by gripping and pulling both ends of the bag body 2.
  • the first pressure-sensitive adhesive layer 3 is not particularly limited as long as it has an adhesive force capable of exerting the above function, and the skin force is such that the pain is not felt when the cooling sheet 1 is peeled off. Adhesive strength is preferably used.
  • the pressure-sensitive adhesive used for the first pressure-sensitive adhesive layer 3 is not particularly limited as long as it has such pressure-sensitive properties.
  • a pressure-sensitive adhesive containing one or more selected base polymers And one or more of these can be used in combination.
  • the first pressure-sensitive adhesive layer 3 hardly remains on the skin after exfoliation from the skin.
  • the first pressure-sensitive adhesive layer 3 is provided with necessary additives, for example, a stabilizer, a tackifier, a pigment, a dye, for the purpose of adjusting tackiness (adhesiveness) and improving safety. It may contain one or two or more kinds selected from the above.
  • the first pressure-sensitive adhesive layer 3 preferably has a substantially constant thickness. This
  • the site to be punctured can be uniformly cooled.
  • the average thickness of the first pressure-sensitive adhesive layer 3 is not particularly limited, but is preferably about 100 m-5 mm, more preferably about m-10 mm. This makes it possible to prevent the skin force cooling sheet 1 from being unintentionally detached while improving the cooling effect on the site to be punctured.
  • the area of the first pressure-sensitive adhesive layer 3 in plan view is preferably about 10 to 40 cm 2 , more preferably about 15 to 30 cm 2. preferable.
  • Such a first pressure-sensitive adhesive layer 3 may contain a drug. Although there are various types of this drug, a bactericidal / disinfectant or a local anesthetic is particularly preferable. At least one kind can be used.
  • disinfectants include chlorobutanol, ethyl alcohol, benzalco-dum chloride, atalinol, isopropanol, gela-ol denatured alcohol, sodium thiosulfate, chlorhexidine dalconate, popidone, iodine tincture, etc.
  • chlorhexidine dalconate or a mixture of sodium thiosulfate and geranine-denatured alcohol is particularly preferable.
  • Examples of the local anesthetic include lidocaine, proforce, tetracaine, dibuforce, mepinocaine, prilocaine, bupivaforce, and ethyl ethyl aminobenzoate. Particularly, lidocaine is used. It is suitable.
  • the first pressure-sensitive adhesive layer 3 may contain a drug other than the above-mentioned drugs.
  • the drug is not particularly limited as long as it effectively contributes to the achievement of the object of the present invention.
  • the surface facing the bag 2 in a folded state (the outer surface on the right side of the first space 21 of the bag 2 in FIG. 2, and the outer surface on the left side with respect to the second space 22) )
  • the force at which the first pressure-sensitive adhesive layer 3 is provided on one side The pressure-sensitive adhesive layer may be provided on both of the opposing surfaces.
  • one of the pressure-sensitive adhesive layers contains a hemostatic agent as a drug.
  • the other pressure-sensitive adhesive layer does not contain a hemostatic agent, but contains the above-mentioned disinfectant or local anesthetic. It is advisable to use a cooling sheet with the agent layer in contact with the site to be punctured.
  • hemostatic agent examples include gelatin, cellulose, thrombin or thrombin-like substance, fibrin monomer, fibrinogen, vitamin, blood coagulation factor VIII, and blood coagulation factor.
  • Factor IX Hemocoadalase (a snake venom preparation) and the like.
  • cooling sheet 1 has release sheet 7 for protecting first pressure-sensitive adhesive layer 3 when not used (before use).
  • the release sheet 7 By providing the release sheet 7, the function of protecting the first pressure-sensitive adhesive layer 3 from microorganisms such as bacteria and viruses and the decrease in the adhesiveness of the first pressure-sensitive adhesive layer 3 until use are reduced. The function to prevent this is exhibited.
  • release sheet 7 various ones can be used, and there is no particular limitation.
  • 1S a film of aluminum, cellulose, polyester, polyethylene, polypropylene, or the like, a multilayer film in which these are laminated, or the like is used. Can be used.
  • the release sheet 7 has a surface (right side in FIG. 2) on the first pressure-sensitive adhesive layer 3 side, for example, a surface treatment with silicon, a surfactant, fluorocarbon, or the like, or an uneven surface treatment. (Embossing) or the like, or necessary additives may be added to the release sheet 7. Thereby, the releasability of the release sheet 7 from the first pressure-sensitive adhesive layer 3 can be adjusted to a desired value.
  • the average thickness of the release sheet 7 is not particularly limited, but is, for example, preferably about 10-100 / zm, more preferably about 25-75 ⁇ m.
  • the outer surface of the opposing outer surface is opposite to the surface on which the first adhesive layer 3 is provided.
  • the first pressure-sensitive adhesive layer 3 may be adhered.
  • the releasability like the release sheet 7 described above is imparted to the surface of the bag 2. This allows the surface to exhibit the same function as the release sheet 7 and, when not in use (before use), keeps the bag 2 in a folded state as shown in FIGS. 1 and 2.
  • a second pressure-sensitive adhesive layer 4 is attached to the outer surface of the bag 2 which is not used (before use) and which is opposite to the outer surface facing the same when not in use.
  • the second pressure-sensitive adhesive layer 4 is fixed (fixed) to the outer surface of the bag body 2 by, for example, adhesion using a fusion bonding adhesive.
  • the bag 2 When the second pressure-sensitive adhesive layer 4 is used (when the cooling sheet 1 is adhered to a site to be punctured), the bag 2 is bent in the opposite direction to when the bag 2 is not used (before use). With the first pressure-sensitive adhesive layer 3 on the outside, the above-mentioned state is maintained by laminating the outer surfaces on the opposite side of the bag body 2 with each other. It has a function to do.
  • the second pressure-sensitive adhesive layer 4 the same one as the first pressure-sensitive adhesive layer 3 can be used. Used for the first pressure-sensitive adhesive layer 3
  • the cooling sheet 1 has a release sheet 8 that protects the second pressure-sensitive adhesive layer 4 when not in use (before use).
  • release sheet 8 the same release sheet 7 as described above can be used.
  • the cooling sheet 1 is provided with a fixing member 10 for fixing the bag 2 in a folded state when not used (before use) as shown in Figs. 1 and 2.
  • the fixing member 10 can be easily removed at the time of use. Thereby, the folded state can be released at the time of use.
  • an adhesive tape is used as the fixing member 10, and the adhesive tape fixes the ends (upper ends in FIGS. 1 and 2) of the bag 2 to each other.
  • the fixing member 10 is not limited to the above-mentioned adhesive tape as long as it exhibits the above-mentioned fixing function, and may be, for example, a holding member 9 described later.
  • the sheet described above is placed in a cooling container to be described later.
  • the partition 23 of the bag 2 is provided with the partition 23 for the purpose of maintaining the isolated state and obtaining an easy restoring force. Further, reinforcement by laminating may be applied. That is, a reinforcing layer may be provided on the partition 23 of the bag 2. In this case, the reinforcing layer is provided on one or both of the two sheets constituting the bag 2.
  • the two sheet materials constituting the bag 2 are composed of an inner sheet material on the side in contact with the skin and an outer sheet material on the opposite side, but from the viewpoint of heat insulation, the reinforcing layer is formed of the outer sheet material. Is preferably provided.
  • the laminated reinforcing layer is formed not only in the partition portion 23 but also in the partition portion 23.
  • the belt-like reinforcement may be applied to both ends of the bag body 2 so as to be orthogonal to.
  • the reinforcing layer may be provided so as to connect not only the partition 23 but also the four corners of the bag body 2 with diagonal lines.
  • the sheet material of the bag 2 It may be provided on the entire surface.
  • the film used for the reinforcing layer a film having higher strength than the sheet material of the bag 2 can be used.
  • the material include, but are not particularly limited to, polyester resin film, polyamide resin film, polypropylene resin film, polyolefin film, polychlorinated butyl film, acetal resin film, and the like.
  • polyester resin films and polyamide resin films are preferable.
  • the thickness of the above-mentioned film is arbitrary.
  • the force is preferably 5 to 100 m S, and particularly preferably 10 to 30 m.
  • laminating adhesive a commonly used laminating adhesive can be used.
  • Acrylics polyamides, polyesters, polyethers, polyurethanes, epoxies, rubbers, etc., with urethanes being particularly preferred.
  • the cooling sheet 1 as described above can be used, for example, as follows.
  • both ends (upper portions in Figs. 1 and 2) of the bag body 2 are respectively gripped, and the bag body 2 is changed from the state shown in Figs. extend. As a result, the first space 21 and the second space 22 of the bag 2 are communicated with each other.
  • the release sheet 8 is peeled off.
  • the bag 2 is bent to the side opposite to that before use, and the outer surfaces of the bag 2 are adhered to each other by the second adhesive layer 4. Thereby, the bag body 2 is maintained in a state as shown in FIG.
  • the release sheet 7 is peeled off and adhered to the skin S so that the first pressure-sensitive adhesive layer 3 covers the planned puncture site S1 and comes into contact with the planned puncture site S1. Thereby, the punctured site S1 is cooled by the endothermic reaction between the first substance 5 and the second substance 6.
  • the cooling sheet 1 is peeled from the skin S.
  • the cooled puncture site S1 is punctured with an injection needle or the like.
  • the scheduled puncture site S1 is sufficiently cooled, Pain associated with puncture is reduced due to paralysis of pain.
  • the use of the cooling sheet 1 can reduce pain at the time of puncturing.
  • the site to be punctured can be gradually cooled, so that the danger of shock due to rapid cooling can be avoided, and safety can be avoided. High.
  • the duration of the cooling effect is relatively short, and the cooling agent (gas component) often has flammability or anesthetic action. Therefore, there are many inconveniences such as careful handling, difficulty in confirming the remaining amount of coolant in the spray can, and troublesome disposal of empty cans after use.
  • the configuration of the partitioning section 23 is the same as that shown in the drawing if the first space and the second space can be separated from each other by folding the bag body 2.
  • the present invention is not limited to this, and various modifications and configurations can be added.
  • FIG. 6 is a plan view showing a cooling sheet according to a second embodiment of the present invention
  • FIG. 7 is a sectional view taken along line BB in FIG.
  • the upper side in FIG. 6 will be described as “upper”, the lower side as “lower”, the upper side in FIG. 7 as “upper”, and the lower side as “lower”.
  • the cooling sheet 1 ′ of the second embodiment has a configuration in which the shape of the bag 2 ′ is different from the position where the second pressure-sensitive adhesive layer 4 is provided, and the folded state of the bag 2 ′ is maintained. Otherwise, the cooling sheet is the same as the cooling sheet of the first embodiment.
  • the width of the communication path between the first space 21 and the second space 22 in the lower portion of the bag 2 ' is smaller than that of the other portions. Then, the first passage 21 and the second space 22 are separated from each other by forming a partition 23 'by bending the communication path of the bag 2'.
  • the first substance 5 and the second substance 6 can be gradually brought into contact, and the cooling effect can be maintained for a longer time, the cooling temperature can be adjusted, and the like.
  • the holding member 9 is detachable from the bag body 2 so that it can be easily removed from the bag body 2 during use. Thus, at the time of use, the first space 21 and the second space 22 can be easily brought into a communicating state.
  • the holding member 9 has a U-shaped cross section parallel to the paper surface of FIG. 7, and can hold the partition 23 'of the bag 2'. ing. Specifically, the partition 23 ′ of the bag 2 ′ is inserted into the holding member 9 with its downward force, whereby the partition 23 ′ is held by the holding member 9.
  • the configuration of the holding member 9 is not limited to the above-described configuration as long as the partitioning portion 23 'of the bag body 2 can be held and maintained in that state.
  • the holding member may be such that the bag body 2 'in FIG.
  • the holding member may be a member that holds a part of the partition portion 23 'without extending over the entire left-right direction of the partition portion 23' in FIG.
  • the cooling sheet 1 ′ shown in FIGS. 6 and 7 has the second pressure-sensitive adhesive layer 4 and the release sheet 8. Is attached to the top of the bag 2. Thereby, at the time of use, the bag body 2 'can be more stably held in a state of being bent to the opposite side to that before use.
  • the seal portion 20 ′ of the bag 2 ′ is wider than the width T 1S of the partition portion 23 ′ and the vicinity thereof, and the width T of other portions. . This allows the partition
  • the width of the partition 23 'of the bag body 2' is narrower than other portions, and a relatively large load is applied to the partition 23 'and the vicinity thereof during the mixing. Therefore, such a configuration is effective.
  • the seal portion 20 ' has a higher adhesive strength at the partition portion 23' and the vicinity thereof than at other portions. This also prevents the seal portion 20 'from being damaged, as described above.
  • the cooling sheet of the present invention has been described based on the illustrated embodiment, but the present invention is not limited to this.
  • the configurations of the first embodiment and the second embodiment can be combined. That is, in the first embodiment, similarly to the second embodiment, the partition portion 23 may be held by a holding member. It may be provided on the upper part.
  • each component constituting the cooling sheet of the present invention can be replaced with any component having the same function, and an optional configuration can be added.
  • the bag body is bent to the opposite side from before use in use has been described, but after the communication between the first space and the second space, the bag body is again bent.
  • the cooling sheet can be folded and used as before.
  • the first pressure-sensitive adhesive layer is provided on the surface of the bag on the side where the cooling sheet comes into contact with the skin during use.
  • the cooling sheet has been described as having a main purpose of relieving pain when a needle is punctured.
  • the type of injection, injection site, etc. are not particularly limited. It is possible to alleviate the pain for various injections.
  • Examples of the types of injections targeted by the present invention include venous indwelling needle puncture, epidural anesthesia, spinal anesthesia, nerve block, various vaccinations, and insulin self-injection.
  • cooling sheet of the present invention can be applied to these. It can also be used for anesthesia level checking and bleeding prevention, not just for pain prevention.
  • FIG. 8 is a plan view (internal perspective view) showing the first embodiment of the cooling container of the present invention
  • FIG. 9 is a sectional view taken along the line CC in FIG. 8, and FIG. It is a longitudinal cross-sectional view showing the state where it did.
  • the front side in FIG. 8 is referred to as “up”
  • the back side in FIG. 8 is referred to as “down”
  • the upper side in FIG. 9 is referred to as “up”
  • the lower side is referred to as “lower”
  • the upper side in FIG. The upper and lower sides are described as “lower”.
  • the cooling container 101 has a storage container 102 storing two kinds of substances, and an adhesive layer 105 provided on the lower surface of the storage container 102.
  • This cooling container (cooling body) 101 cools a site to be punctured on the surface of a living body (hereinafter, referred to as "skin"), for example, prior to a puncturing operation. Pain (pain
  • the storage container 102 includes a container main body 128 and a lid 129 attached so as to be accessible (displaceable) to the container main body 128.
  • the container main body 128 is formed of a bottomed cylindrical member.
  • the side wall of the container body 128 has a substantially cylindrical shape, and a thread groove 281 is formed on the upper outer surface thereof. With this thread groove 281
  • the thread 291 of the lid 129 described later is screwed together, and the lid 129 is mounted on the container body 128.
  • a first protruding portion 282 and a second protruding portion 283 are provided on the inner surface of the side wall portion of the container main body 128 at the middle and the upper end in the height direction, respectively.
  • Each protruding portion 282, 283 is formed, for example, in a ring shape.
  • the first protruding portion 282 will be described later.
  • Rupturable sheet (partition part) 108 is fixed (fixed).
  • the lid 129 is also formed of a bottomed cylindrical member.
  • the side wall of the lid 129 has a substantially cylindrical shape, and a thread 291 to be screwed into the thread groove 281 is formed on the lower inner surface thereof.
  • the lid 129 can be made to approach the container main body 128 by rotating the lid 129 relatively to the container main body 128.
  • a fixing portion 292 for fixing the needle (release member) 106 is provided at the center of the inner surface of the ceiling of the cover 129 (the surface on the first space 121 side described later). Needle body 106 is fixed to fixing portion 292 by, for example, a method such as fusion, adhesion with an adhesive, fitting, and caulking.
  • the needle body 106 has a sharp needle tip at the tip (the lower end in Fig. 9), and the needle tip is brought into contact with the easily rupturable sheet 108 to rupture (rupture) the easily rupturable sheet 108. It can be done.
  • Needle body 106 may be formed integrally with lid body 129.
  • An elastic member 129 is provided at the edge of the inner surface of the ceiling of the lid 129 (the surface on the first space 121 side described later).
  • the elastic member 129 is formed, for example, in a ring shape. With such a configuration, the lid 129 is relatively rotated with respect to the container main body 128, and the liquid tightness or the liquid tightness of the storage container 102 when the lid 129 and the container main body 128 come close to each other. The airtightness can be improved.
  • the easily rupturable sheet (partition portion) 108 has an edge fixed (fixed) to the first protruding portion 282 described above.
  • the internal space 120 of the storage container 102 is partitioned into the adjacent first space 121 and second space 122.
  • These compartment states depend on the substances (the first substance 103 and the second substance 104) contained in the first space 121 and the second space 122, but are preferably liquid-tight or air-tight.
  • the material constituting the easily rupturable sheet 108 is not particularly limited, and well-known materials can be appropriately used. For example, films such as aluminum, cellulose, polyester, polyethylene, and polypropylene, A laminated multilayer film or the like can be used.
  • Such a container body 128 changes from the state shown in Fig. 9 to the state shown in Fig. 10 during use.
  • the isolation by the rupturable sheet 108 is released, and the first space 1
  • the first substance 103 is stored, and in the second space 122, the second substance 104 is stored.
  • the first substance 103 and the second substance 104 cause an endothermic reaction when they come into contact with each other.
  • the present invention uses this endothermic reaction as a cooling means to cool the site to be punctured.
  • the endothermic reaction is not limited to a reaction involving a change in chemical structure, but also includes a reaction due to dissolution or the like.
  • the cooling container 101 is preferably capable of maintaining the temperature of the skin (the site to be punctured) at 5 ° C to 20 ° C for 5 minutes or more due to an endothermic reaction. — More preferred is one that can be held at 18 ° C for more than 7 minutes. By satisfying such conditions, it is possible to effectively cool the site to be punctured, and to effectively alleviate the pain caused by puncturing even after the cooling container 101 is peeled off from the site to be punctured.
  • the cooling temperature is too low, the site to be punctured may be excessively cooled, causing frostbite, and excessive cooling may cause pain. On the other hand, if the cooling temperature is too high, there is a possibility that the pain relieving effect at the time of puncturing cannot be sufficiently obtained.
  • the duration (retention time) is too short, the site to be punctured may not be sufficiently cooled, and the pain relieving effect at the time of puncture may not be sufficiently obtained.
  • the first substance (cryogen) 103 is not particularly limited as long as it gives an endothermic reaction when it comes into contact with a second substance 104 described later.
  • a second substance 104 for example, ammonium nitrate, potassium nitrate, sodium nitrate, Silver thiocyanate, boric acid, ammonium salt, ammonium carbonate, ammonium azide, ammonium nitrite, ammonium cyanate, ammonium phosphate trihydrate, ammonium thiocyanate, tetraammonium Sodium borate decahydrate, sodium hydrogen phosphate dodecahydrate, 1-aspartic acid, salicylic acid, oxalic acid dihydrate, guanidine nitrate, urine nitrate, sodium nitrite, urea, ammonium rubbamate, ammonium carbonate -Palm, calcium nitrate, crystal salt, calcium sulfate, magnesium sulfate, potassium thiocyanate, potassium carbonate
  • the first substance 103 is preferably a substance mainly composed of ammonium nitrate, chloride ammonium chloride, and ammonium thiocyanate.
  • the main component is more preferably.
  • the first substance 103 When two or more substances are used as the first substance 103, one of them is a substance having a high immediate effect as a cooling effect and the other is a substance having a high persistence, so that The cooling effect can be exhibited and the cooling effect can be maintained for a long time.
  • the form (shape) of the first substance 103 may be, for example, any of a powder form, a flake form, a small lump form (a pellet form), and the like. It is preferable to use one. Thereby, mixing with the second substance 104 is facilitated, and the dissolution rate can be increased. As a result, a cooling effect can be exhibited in a shorter time.
  • the first substance 103 is in the form of a powder, its average particle size is not particularly limited.
  • the average particle size of the first substance 103 is less than the lower limit, the scattering property is increased and the adjustment becomes complicated.
  • the average particle size of the first substance 103 exceeds the upper limit, the mixing property with the second substance 104 is reduced, and a sufficient cooling effect (pain alleviation effect) is not obtained. It takes a long time after applying a cooling container to reach a state in which pain relief can be expected, or immediate effects cannot be expected.
  • the second substance (liquid agent) 104 is not particularly limited as long as it causes an endothermic reaction upon contact with the first substance 103 described above.
  • the second substance 104 is preferably barium hydroxide octahydrate, which is preferably a substance mainly composed of water and barium hydroxide octahydrate. Components are more preferred. By using the strong second substance 104, a cooling effect can be exhibited in a shorter time.
  • the form of the second substance 104 may be, for example, any of liquid, solid, and gel.
  • the space between the first space 121 and the second space 122 is not completely sealed with liquid tightness (air tightness).
  • undesired reaction between the first substance 103 and the second substance 104 can be prevented when not in use (before use).
  • the second substance 104 when a solid or gel-like substance is used as the second substance 104, if the second substance 104 is formed into a powder, a scale, or a small lump (pellet), In addition, mixing with the first substance 3 becomes easy, and the dissolution rate can be increased. As a result, a cooling effect can be exhibited in a shorter time. From this point, it is particularly preferable to make the second substance 104 into a powder.
  • the average particle size is not particularly limited, but is preferably 1 ⁇ m to 3 mm, more preferably 50 m to 1 mm. If the average particle size of the second substance 104 is less than the lower limit, the scattering property is increased and the adjustment becomes complicated. On the other hand, when the average particle size of the second substance 104 exceeds the upper limit, the miscibility with the first substance 103 is reduced, and a sufficient cooling effect (pain alleviation effect) cannot be obtained. In addition, it takes a long time after the cooling container is attached to the state where the pain relief effect can be expected, and the immediate effect cannot be expected.
  • first substance 103 and the second substance 104 include a gelling agent and a polymer for the purpose of, for example, improving the usability and obtaining a sustained cooling effect. Add some calories.
  • the gelling agent is not particularly limited, but for example, a crosslinked polymer having a repeating unit of an amide-based compound as a main repeating unit is suitably used.
  • amide compound examples include N-bulformamide and N-bulacetoamide , N-methyl-N-butylformamide, N-methyl-N-butylacetamide and the like.
  • the polymer is not particularly limited !, but, for example, gum arabic, tragacanth, locust bean gum, guar gum, echo gum, karaya gum, agar, starch, power lagenan, alginic acid, alginate (eg, alginic acid) Sodium), natural polymers such as propylene glycol alginate, dextran, dextrin, amylose, gelatin, collagen, pullulan, pectin, amylopectin, starch, amylopectin sodium semiglycolate, chitin, albumin, casein , Polyglutamic acid, polyaspartic acid, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylstarch, carboxymethylstarch, alkali metal carboxymethylcellulose, alkali metal cell Semi-synthetic polymers such as cellulose sulfate, cellulose rough polymer, cross-linked gelatin, cellulose acetate phthalate
  • bead 110 is housed in second space 122 in addition to second substance 104.
  • first substance 103 and the second substance 104 can be mixed more quickly, and as a result, a cooling effect can be exhibited in a shorter time.
  • the material constituting the beads 110 is not particularly limited, but a resin material is preferably used. As a result, the first substance 103 and the second The quality 104 can be mixed more quickly.
  • the resin material constituting the beads 110 is preferably a resin material that does not react with the first substance 103 and the second substance 104 described above and that can be easily formed into beads.
  • styrene resins for example, polystyrene, butadiene styrene copolymer, acrylonitrile styrene copolymer, acrylonitrile butadiene styrene copolymer, etc.
  • ABS resin for example, polystyrene resin, butadiene styrene copolymer, acrylonitrile styrene copolymer, acrylonitrile butadiene styrene copolymer, etc.
  • ABS resin for example, polystyrene resin, butadiene styrene copolymer, acrylonitrile styrene copolymer, acrylonitrile butadiene styrene copolymer, etc.
  • the shape of such beads 110 is not particularly limited, but is preferably spherical.
  • the first substance 103 and the second substance 104 can be mixed more quickly.
  • the average particle size of the beads 110 is not particularly limited, and is preferably 100 m to 5 mm.
  • the first substance 103 and the second substance 104 can be more efficiently mixed.
  • the content of the beads 110 is not particularly limited, but is preferably 1 to 50 parts by mass when the whole substance contained in the cooling container 101 is 100 parts by mass. If the content of the beads 110 is less than the lower limit, the mixing speed of the first substance 103 and the second substance 104 may not be sufficiently improved. On the other hand, if the content of the beads 110 exceeds the upper limit, the mixing of the first substance 103 and the second substance 104 may be hampered.
  • the beads 110 are described as being housed in the second space 122. However, the beads 110 may be housed in the first space 121, or may be housed in the first space 121. The space 121 and And in both the second space 122 and the second space 122. That is, the beads 110 may be mixed with the first substance 103, may be mixed with the second substance 104, or may be mixed with both.
  • the storage container 102 (container main body 128, lid 129) as described above preferably has a water vapor barrier property.
  • the water vapor nobility refers to a water vapor permeability of preferably 30 gZm 2 ⁇ 24 hrs ⁇ 25 ⁇ m thickness ⁇ 40 ° C ⁇ 90% RH or less, more preferably 10 g / m 2 ⁇ 24 hrs ⁇ 25 m thickness.
  • ⁇ 40 ° C ⁇ 90% RH or less more preferably lg / m 2 ⁇ 24hrs ⁇ 25m thickness ⁇ 40 ° C 'means 90% RH or less.
  • This water vapor permeability is measured by the method described in JIS K7129 (Method A).
  • the storage container 102 has the steam barrier property as described above, it is possible to prevent water vapor from entering the inside of the storage container 102 or to use water containing the second substance 104 as a main component. In addition, evaporation of water from the second space 122 can be prevented. Further, when not in use (before use), it is possible to prevent the endothermic reaction between the first substance 103 and moisture due to the invasion of water vapor into the first space 121.
  • the second substance 104 when a substance mainly composed of water is used as the second substance 104, the reduction and concentration of the substance can be prevented, and the amount of the second substance 104 can be minimized.
  • the volume and mass of the entire cooling vessel 101 can be reduced. Further, it is possible to prevent penetration of water vapor into the space 12 inside the first i th externally these container 102.
  • the material constituting the storage container 102 is not particularly limited as long as it has flexibility and sufficient strength and does not leak the substance stored therein.
  • styrene resins for example, polystyrene, butadiene'styrene copolymer, acrylonitrile'styrene copolymer, acrylonitrile'butadiene'styrene copolymer, etc.
  • ABS resin for example, polystyrene resin, butadiene'styrene copolymer, acrylonitrile'styrene copolymer, acrylonitrile'butadiene'styrene copolymer, etc.
  • ABS resin for example, polystyrene resin, butadiene'styrene copolymer, acrylonitrile'styrene copolymer, acrylonitrile'butadiene'styrene copolymer, etc.
  • ABS resin for example, polyst
  • Fats eg, hydroxycarboxylic acid condensates such as polylactic acid, polybutadiene
  • thermoplastic resin such as liquid crystal polymer, urethane resin, epoxy resin, phenol resin, urea resin, melamine resin, unsaturated polyester resin, etc. Examples thereof include thermosetting resins, and one or more of these can be used in combination.
  • the storage container 102 for example, in addition to those formed of the above-described materials, those in which aluminum, silica, or the like is deposited thereon can also be used. Thereby, the liquid tightness, air tightness, and the like of the storage container 102 can be improved.
  • the average thickness of the wall surfaces of the container body 128 and the lid 129 is not particularly limited, but is usually preferably about 0.1 to 2 mm.
  • the diameter of the storage container 102 in plan view is preferably about 35 to 71 mm.
  • An adhesive layer 105 is provided on the lower surface of the storage container 102, that is, on the surface of the container main body 128 opposite to the lid 129.
  • the pressure-sensitive adhesive layer 105 has a function of fixing the cooling container 101 to the skin during use. This prevents the cooling container 101 from unintentionally releasing the skin force during use.
  • the pressure-sensitive adhesive layer 105 is not particularly limited as long as it has an adhesive force capable of exerting the above-mentioned function, and the pressure-sensitive adhesive layer has a skin force that does not cause pain when the cooling container 101 is peeled off. Is preferably used.
  • the shape of the pressure-sensitive adhesive layer 105 changes in accordance with the shape of the surface to be stuck. Thereby, the skin force can also prevent the cooling container 101 from being unintentionally separated.
  • the pressure-sensitive adhesive used for the pressure-sensitive adhesive layer 105 is not particularly limited, and examples thereof include an acrylate polymer, sodium carboxymethyl cellulose, a styrene isoprene styrene block copolymer, a natural rubber, a butyl ether copolymer, and a polyacryl. Sodium acid, polydimethylsiloxane, methacrylic acid ester polymer, etc. A pressure-sensitive adhesive having one or more selected base polymers is used, and one or more of these may be used in combination. Can be.
  • the pressure-sensitive adhesive layer 105 is in direct contact with the skin, it is preferable that the pressure-sensitive adhesive layer 105 is less irritating to the skin and has excellent safety. In particular, after the adhesive layer 105 is peeled from the skin, It is less likely to remain on the skin and is preferred.
  • the pressure-sensitive adhesive layer 105 is provided with necessary additives such as stabilizers, tackifiers, pigments, dyes, and the like for the purpose of adjusting the tackiness (adhesion) and improving safety.
  • necessary additives such as stabilizers, tackifiers, pigments, dyes, and the like for the purpose of adjusting the tackiness (adhesion) and improving safety.
  • tackiness adheresion
  • dyes dyes, and the like for the purpose of adjusting the tackiness (adhesion) and improving safety.
  • One or more selected ones may be contained.
  • the pressure-sensitive adhesive layer 105 has a substantially constant thickness. Thereby, it becomes possible to uniformly cool the site to be punctured.
  • the average thickness of the pressure-sensitive adhesive layer 105 is not particularly limited, but is preferably about 10 ⁇ m to 10 mm, more preferably about 100 m to 5 mm. Thereby, it is possible to prevent the cooling container 101 from being unintentionally separated from the skin while improving the cooling effect on the site to be punctured.
  • the area in plan view of the pressure-sensitive adhesive layer 105 is more preferably the preferred tool 15-30 cm 2 approximately in the range of about 10- 40 cm 2.
  • Such an adhesive layer 105 may contain a drug.
  • a drug there are various drugs, and in particular, a disinfectant or a disinfectant or a local anesthetic is preferable, and at least one of these can be used.
  • Disinfectants and disinfectants include, for example, chlorobutanol, ethyl alcohol, benzalco-dum chloride, atalinol, isopropanol, gel-ol denatured alcohol, sodium thiosulfate, chlorhexidine dalconate, popidone, iodine tincture, etc. .
  • chlorhexidine dalconate or a mixture of sodium thiosulfate and geranine-denatured alcohol is particularly preferable.
  • a local anesthetic When a local anesthetic is used as a drug, the pain relieving effect at the time of puncture is more effectively exerted.
  • Examples of local anesthetics include lidocaine, proforce, tetracaine, jib force, mepinocaine, prilocaine, bupiva force, and ethyl ethyl benzoate.
  • the pressure-sensitive adhesive layer 105 may contain other drugs other than the above-mentioned drugs.
  • the drug is not particularly limited as long as it effectively contributes to achieving the object of the present invention.
  • the pressure-sensitive adhesive layer 105 is provided on the surface of the container body 128 opposite to the lid 129.
  • the pressure-sensitive adhesive layer is also provided on the surface of the lid 129 opposite to the container body 128. May be provided. That is, the pressure-sensitive adhesive layer may be provided on both sides of the cooling container 101 facing each other.
  • one of the pressure-sensitive adhesive layers contains a hemostatic agent as a drug.
  • the other pressure-sensitive adhesive layer does not contain a hemostatic agent but contains the aforementioned disinfectant or local anesthetic, and before puncturing, punctures this pressure-sensitive adhesive layer. It is advisable to use a cooling vessel in contact with the intended site.
  • hemostatic agent examples include gelatin, cellulose, thrombin or a thrombin-like substance, fibrin monomer, fibrinogen, vitamin, blood coagulation factor VIII, blood coagulation factor IX, and hemocoadalase (a snake venom preparation).
  • cooling container 101 has release sheet 7 for protecting pressure-sensitive adhesive layer 105 when not in use (before use).
  • the release sheet 107 By providing the release sheet 107, a function of protecting the pressure-sensitive adhesive layer 105 from microorganisms such as bacteria and viruses and a function of preventing the pressure-sensitive adhesive layer 105 from lowering its adhesiveness until the time of use are exhibited. You.
  • Various materials can be used as the release sheet 107, and are not particularly limited.
  • a film of aluminum, cellulose, polyester, polyethylene, polypropylene, or the like, or a multilayer in which these are laminated is used.
  • a film or the like can be used.
  • the release sheet 107 has, for example, a surface on the pressure-sensitive adhesive layer 105 side (the right surface in FIG. 9) Surface treatment with silicon, a surfactant, fluorocarbon, or the like, surface unevenness (enbossing), or addition of a necessary additive to the release sheet 107 may be performed. Thereby, the releasability of the release sheet 107 from the pressure-sensitive adhesive layer 105 can be adjusted to a desired value.
  • the average thickness of the release sheet 107 is not particularly limited, but is, for example, preferably about 10 to 100 Pm, more preferably about 25 to 75 Pm.
  • the cooling container 101 as described above can be used, for example, as follows.
  • the lid 109 is rotated with respect to the container main body 128, and the storage container 102 is changed from the state shown in FIG. 9 to the state shown in FIG. 10, and is formed on the inner surface of the ceiling of the lid 129.
  • the breakable sheet 108 is ruptured (ruptured) by the needle 106 that is present. Thereby, the first space 121 and the second space 122 of the storage container 102 are communicated.
  • the release sheet 107 is peeled off to expose the adhesive layer 105.
  • the cooling container 101 is adhered to the skin by the adhesive layer 105 so as to come into contact with the site to be punctured. Thereby, the site to be punctured is cooled by the endothermic reaction between first substance 103 and second substance 104.
  • cooling container 101 is peeled from the skin.
  • the cooled puncture site is punctured with an injection needle or the like.
  • the site to be punctured is sufficiently cooled, and the pain at the site to be punctured is paralyzed, so that the pain (pain) accompanying the puncture is alleviated.
  • the pressure-sensitive adhesive is based on the type of chemicals. The effect is exhibited, and pain at the time of puncturing can be more effectively alleviated.
  • the storage container 102 can be made more compact and the cost can be reduced.
  • the planned puncture site can be gradually cooled, so that the danger of shock due to rapid cooling can be avoided, and safety can be prevented. High.
  • the duration of the cooling effect is relatively short, and in many cases, the coolant (gas component) has flammability or anesthetic action. Therefore, there are many inconveniences such as careful handling, difficulty in confirming the remaining amount of coolant in the spray can, and troublesome disposal of empty cans after use.
  • the configuration of the storage container 102 is such that the operation of displacing the lid 129 with respect to the container main body 128 is performed so that the first space defined by the partition portion 108 is formed.
  • the configuration is not limited to the illustrated configuration as long as it can release the state of isolation from the second space, and various modifications and configurations can be added.
  • FIG. 11 is a longitudinal sectional view showing a second embodiment of the cooling container of the present invention.
  • the upper side in FIG. 11 is described as “upper”, and the lower side is described as “lower”.
  • cooling container of the second embodiment will be described, but the description will focus on differences from the cooling container of the first embodiment, and description of the same items will be omitted.
  • the cooling container 101 'of the second embodiment is different from the cooling container 101' in that the shape and material of the lid 129 'are different and the operation of displacing the lid 129' with respect to the container body 128 is different. This is the same as the cooling container of the first embodiment.
  • the lid 129' has elasticity.
  • the lid 129 ' has a shape curved upward.
  • the lid 129 ' is fixed to the container body 128 at the edge.
  • the lid 129 ' With the lid 129 'having such a configuration, the lid 129' is pressed against the container body 128 by pressing the lid 129 'toward the container body 128, whereby the needle 106 formed on the inner surface of the ceiling portion of the lid 129' is formed. Is brought close to the easily breakable sheet 108, and the easily breakable sheet 108 can be ruptured (ruptured). As a result, the first substance 103 and the second substance 104 are mixed and exhibit a cooling effect.
  • the material constituting the lid 129 'having such elasticity is not particularly limited, and examples thereof include various metal materials such as aluminum, panel steel, and stainless steel, and the thermoplastic resin and thermosetting described above. And the like.
  • Such a lid 129 ' is formed to have such a thickness as to give a suitable elasticity to the lid 129'.
  • Fig. 12 is a plan view showing a partition part in a third embodiment of the cooling container of the present invention
  • Fig. 13 is a cross-sectional view taken along line DD in Fig. 12 of the third embodiment of the cooling device of the present invention. It is.
  • the front side in FIG. 12 is referred to as “up”
  • the back side in FIG. 12 is referred to as “down”
  • the upper side in FIG. 13 is referred to as “up”
  • the lower side is referred to as “down”.
  • the partition portion 108 ' is formed by stacking a partition plate 181 having a through hole 811 formed thereon and a partition plate 182 having a through hole 821 formed therein.
  • the through-hole 811 and the through-hole 821 are configured so as not to overlap as shown in FIG. Thereby, the first space 121 and the second space 122 described above are partitioned.
  • a projection 812 is provided at a position deviated from the center of the partition plate 181.
  • the protrusion 812 has a function of transmitting the displacement of a release member 106 ′ described later to the partition plate 181.
  • the partition plate 1 arranged on the container body 128 side. 82 is fixed (fixed) to the protrusion 282.
  • a release member 106 ' is provided on the surface of the lid 129 "on the first space 121 side at a position corresponding to the protruding portion 812.
  • the release member 106' is provided in the first embodiment. Similarly to the embodiment, it is fixed to the lid 129 ".
  • the distal end of the release member 106 ' is configured to be pulled by the protrusion 812 when the lid 129 "rotates.
  • the average thickness of the partition plates 181 and 182 is preferably about 0.1 to 1.5 mm.
  • the average diameter of the through holes 811 and 821 is preferably about 3 to 10 mm.
  • each part constituting the cooling container of the present invention has an arbitrary structure exhibiting a similar function. It can be replaced with a configuration, and an arbitrary configuration can be added.
  • the force described in the case where cryogen is stored as the first substance and the liquid medicine is stored as the second substance is not limited thereto, and may be reversed.
  • the cylindrical cooling container has been described.
  • the present invention is not limited to this, and may be a box-shaped cooling container.
  • beads are stored in the second space.
  • the present invention is not limited to this, and beads may be omitted, or beads may be stored in the first space. It may be stored in both the first space and the second space.
  • the force described in the case where the needle is used as the release member is not limited to this.
  • a blade may be used.
  • the partition plate is described as having one through-hole.
  • the present invention is not limited to this, and the number of through-holes may be two. Yes, or three or more.
  • the through hole is described as having a circular shape.
  • the present invention is not limited to this.
  • the through hole may have an elliptical shape or a polygonal shape such as a square. It is good.
  • the partition member is rotated by the release member pressing the projection, but the present invention is not limited to this.
  • the release member and the projection may be connected to each other. It may have a physically formed configuration.
  • the cooling container was described as having a main purpose of relieving pain at the time of puncturing with a syringe needle.
  • the cooling container of the present invention is applicable to various types of injections.
  • the injection site and the like are not particularly limited.
  • the present invention can alleviate the pain of various injections.
  • Examples of the types of injections targeted by the present invention include venous indwelling needle puncture, epidural anesthesia, spinal anesthesia, nerve block, various vaccinations, and insulin self-injection.
  • cooling container of the present invention can be applied to these. In addition, it can be used for checking the level of anesthesia, preventing bleeding, and asthenopia.
  • a cooling sheet as shown in FIGS. 1 and 2 was produced.
  • Sheet material 2-layer lamination of polyethylene and aluminum evaporated polyester
  • Shape in plan view ⁇ Bent state> Square (side length 60mm)
  • First pressure-sensitive adhesive layer Nystack (NW-40, normal adhesive strength, -Chiban Co., Ltd.)
  • Second pressure-sensitive adhesive layer Nystack (NW-40, normal adhesive strength, -Chiban Co., Ltd.)
  • a cooling sheet was applied to the lower arm of the subject (10 subjects) at a site to be punctured for 1 minute. After that, the cooling sheet was peeled off at the scheduled puncture site, and a von Frey-type pain test was performed at predetermined intervals. It was.
  • a partition portion as shown in Fig. 5 was formed in the bag of the above-described embodiment, and the same test was performed. As a result, the same result as described above was obtained. Further, a cooling sheet as shown in FIG. 6 and FIG. 7 was produced, and the same test as above was performed. As a result, the same result as above was obtained.
  • a cooling sheet as shown in FIGS. 1 and 2 was produced. [0312]
  • the specifications of the cooling sheet are as follows.
  • Sheet material 2-layer lamination of polyethylene and aluminum evaporated polyester
  • Shape in plan view ⁇ Bent state> Square (side length 70mm)
  • First pressure-sensitive adhesive layer Nystack (NW-40, normal adhesive strength, -Chiban Co., Ltd.)
  • Second pressure-sensitive adhesive layer Nystack (NW-40, normal adhesive strength, -Chiban Co., Ltd.)
  • Example 1 the same von Frey-type pain test as in Example 1 was performed.
  • a cooling sheet as shown in FIGS. 1 and 2 was produced.
  • Sheet material 2-layer lamination of polyethylene and aluminum evaporated polyester
  • Shape in plan view ⁇ Bent state> Square (side length 70mm)
  • First pressure-sensitive adhesive layer Nystack (NW-40, normal adhesive strength, -Chiban Co., Ltd.)
  • Second pressure-sensitive adhesive layer Nystack (NW-40, normal adhesive strength, -Chiban Co., Ltd.)
  • Example 1 the same von Frey-type pain test as in Example 1 was performed.
  • the cooling sheet and the cooling container of the present invention can be mainly used in the medical field.
  • FIG. 1 is a plan view (an internal transmission diagram) showing an embodiment of a cooling sheet of the present invention.
  • FIG. 2 is a sectional view taken along line AA in FIG. 1.
  • FIG. 3 is a plan view showing a state where the cooling sheet shown in FIG. 1 is expanded.
  • FIG. 4 is a view showing a use state of the cooling sheet of FIG. 1 in a cross section corresponding to FIG. 2.
  • FIG. 5 is an enlarged cross-sectional view showing another example of the partition part of the bag 2.
  • FIG. 6 is a plan view showing another embodiment of the cooling sheet of the present invention.
  • FIG. 7 is a sectional view taken along line BB of the cooling sheet of FIG. 6.
  • FIG. 8 is a plan view (an internal perspective view) showing the first embodiment of the cooling container of the present invention.
  • FIG. 9 is a sectional view taken along line CC in FIG. 8.
  • FIG. 10 is a longitudinal sectional view showing a state where the lid is displaced with respect to the container body.
  • FIG. 11 is a longitudinal sectional view showing a second embodiment of the cooling container of the present invention.
  • FIG. 12 is a plan view showing a partition part in a third embodiment of the cooling container of the present invention.
  • FIG. 13 is a sectional view taken along line DD in FIG. 12 in a cooling device according to a third embodiment of the present invention.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Thermal Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

Feuille de refroidissement et récipient de refroidissement capables de soulager facilement la douleur dans la ponction. La feuille de refroidissement (1) est formée en partitionnant l'intérieur d'un corps de sachet (2) en un premier espace (21) et un second espace (22) par une partie de partition (23) formée en pliant le corps de sac de manière à permettre la communication si nécessaire. Une première substance (5) est stockée dans le premier espace (21), et une seconde substance (6) produisant une réaction endothermique par le contact de cette dernière avec la première substance (5) est stockée dans le second espace (22). Le récipient de refroidissement (101) est formé par le partitionnement de l'intérieur d'un corps de récipient (128) en un premier espace (121) sur le côté de corps de couverture (129) et un second espace 122) sur le côté de corps de récipient (128) par une partie de partition (108). Une première substance (103) est stockée dans le premier espace (121), et un seconde substrat (104) produisant une réaction endothermique par le contact de cette dernière avec la première substance (103) est stockée dans le second espace (122). Un organe de relâche (106) est installé sur la surface du corps de couverture (129) sur le côté du premier espace (121) et le corps de couverture (129) est tourné par rapport au corps de récipient (128) pour libérer l'état partitionné du premier espace (121) du second espace (122) par la partie de partition (108).
PCT/JP2005/005479 2004-03-26 2005-03-25 Feuille de refroidissement et recipient de refroidissement WO2005092257A1 (fr)

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Cited By (11)

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JP2007029638A (ja) * 2005-07-29 2007-02-08 Daiya Seiyaku Kk 冷却シート及び携帯用冷却シート
JP2007296061A (ja) * 2006-04-28 2007-11-15 Okamoto Ind Inc 使い捨てカイロ
WO2011015821A1 (fr) * 2009-08-04 2011-02-10 Julian Joshua Preston-Powers Dispositif de refroidissement du cerveau
JP2012511690A (ja) * 2008-12-09 2012-05-24 カールスバーグ・ブルワリーズ・エー／エス 自己冷却式容器と冷却装置
JP2013172942A (ja) * 2012-01-26 2013-09-05 Takabishi Kagaku Kk 保冷具、その保冷具用袋体及び保冷具の使用方法
WO2013174818A1 (fr) * 2012-05-21 2013-11-28 Roger Franz Wilfinger Dispositif, procédé et utilisation d'un dispositif pour produire un refroidissement local
JP2014516682A (ja) * 2011-05-16 2014-07-17 ザ テクノロジー パートナーシップ パブリック リミテッド カンパニー 用量容器
JP2016198137A (ja) * 2015-04-07 2016-12-01 一昭 溝口 医療用中温帯冷却パック
WO2017140372A1 (fr) 2016-02-19 2017-08-24 Doktor Key Gmbh Dispositif de traitement permettant d'appliquer un effet de refroidissement local
JP2020142011A (ja) * 2019-03-08 2020-09-10 白元アース株式会社 冷却具
FR3128871A1 (fr) * 2021-11-09 2023-05-12 Implants Service Orthopedie Dispositif de cryothérapie gynécologique et/ou obstétrique et/ou proctologique

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007029638A (ja) * 2005-07-29 2007-02-08 Daiya Seiyaku Kk 冷却シート及び携帯用冷却シート
JP2007296061A (ja) * 2006-04-28 2007-11-15 Okamoto Ind Inc 使い捨てカイロ
JP4713395B2 (ja) * 2006-04-28 2011-06-29 オカモト株式会社 使い捨てカイロ
JP2012511690A (ja) * 2008-12-09 2012-05-24 カールスバーグ・ブルワリーズ・エー／エス 自己冷却式容器と冷却装置
WO2011015821A1 (fr) * 2009-08-04 2011-02-10 Julian Joshua Preston-Powers Dispositif de refroidissement du cerveau
JP2014516682A (ja) * 2011-05-16 2014-07-17 ザ テクノロジー パートナーシップ パブリック リミテッド カンパニー 用量容器
JP2013172942A (ja) * 2012-01-26 2013-09-05 Takabishi Kagaku Kk 保冷具、その保冷具用袋体及び保冷具の使用方法
WO2013174818A1 (fr) * 2012-05-21 2013-11-28 Roger Franz Wilfinger Dispositif, procédé et utilisation d'un dispositif pour produire un refroidissement local
JP2016198137A (ja) * 2015-04-07 2016-12-01 一昭 溝口 医療用中温帯冷却パック
WO2017140372A1 (fr) 2016-02-19 2017-08-24 Doktor Key Gmbh Dispositif de traitement permettant d'appliquer un effet de refroidissement local
JP2020142011A (ja) * 2019-03-08 2020-09-10 白元アース株式会社 冷却具
FR3128871A1 (fr) * 2021-11-09 2023-05-12 Implants Service Orthopedie Dispositif de cryothérapie gynécologique et/ou obstétrique et/ou proctologique

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