WO2005077380A1 - 有痛性皮膚創傷の治療用外用剤 - Google Patents
有痛性皮膚創傷の治療用外用剤 Download PDFInfo
- Publication number
- WO2005077380A1 WO2005077380A1 PCT/JP2004/001619 JP2004001619W WO2005077380A1 WO 2005077380 A1 WO2005077380 A1 WO 2005077380A1 JP 2004001619 W JP2004001619 W JP 2004001619W WO 2005077380 A1 WO2005077380 A1 WO 2005077380A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- external preparation
- acetylsalicylic acid
- pain
- acid
- active ingredient
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Definitions
- the present invention relates to an external therapeutic agent having a therapeutic effect on a skin wound with pain and having an analgesic effect on a skin wound site, and a method for treating the same.
- acetinoresalicylic acid or a pharmacologically acceptable salt thereof as an active ingredient is effective in treating painful skin wounds, while at the same time treating skin wounds and simultaneously reducing pain. And a method for treating the same.
- nonsteroidal anti-inflammatory drugs are administered orally as treatments for pain associated with skin wounds. Administration often delays wound healing, and oral administration of non-steroidal anti-inflammatory drugs may cause side effects such as gastric ulcers.
- administering delays wound healing, so administration to a wound site is considered contraindicated.
- wound therapeutic agents have been developed as wound therapeutic agents. Although many of them have an effect of promoting granulation proliferation, administration to wounds in advanced stages such as early burns may worsen symptoms.
- acetylsalicylic acid (hereinafter sometimes referred to aspirin) has been widely used as an antipyretic analgesic for a long time, mainly in the form of oral administration, due to its powerful analgesic, antipyretic and anti-rheumatic effects. It has low side effects and high safety.
- the present invention is intended to solve the above-mentioned problems, and it is an object of the present invention to use acetylsalicylic acid as an active ingredient, which has few side effects, has an excellent inhibitory effect on pain at a skin wound site, and delays healing of a wound site.
- An object of the present invention is to provide a wound healing agent that does not wake up. .
- an external preparation containing acetylsalicylic acid as an active ingredient has reduced side effects and further suppressed pain against painful skin wounds. While showing good wound treatment effect.
- the present invention relates to an external preparation for the treatment of painful skin wounds, which comprises acetylsalicylic acid or a pharmaceutically acceptable salt thereof as an active ingredient and has an analgesic effect.
- the present invention also relates to a method for treating and analgesic painful skin wounds, comprising administering an effective amount of a drug containing acetylsalicylic acid or a pharmaceutically acceptable salt thereof as an active ingredient to an affected part of a patient.
- a drug containing acetylsalicylic acid or a pharmaceutically acceptable salt thereof as an active ingredient to an affected part of a patient.
- the acetylsalicylic acid contained in the external preparation of the present invention is listed in the Pharmacopoeia S.
- the content of acetylsalicylic acid in the external preparation varies depending on the dosage form, but has a sufficient effect on the total weight of the preparation. 0 is obtained a. 0 1-8 0 weight 0/0, preferably 0. 0 1-7 0 weight 0/0, more preferably 0. 0 5 to 5 0 wt%. If the content of acetylsalicylic acid is less than 0.01% by weight, the action of acetylsalicylic acid for suppressing pain and wound healing is not sufficiently exhibited, which is not preferable. If the content of acetylsalicylic acid is 80% by weight or more, it becomes difficult to prepare a preparation.
- the active ingredient contained in the external preparation for treatment of the present invention includes, in addition to acetylsalicylic acid, salts of acetylsalicylic acid with amino acids such as pharmacologically acceptable DL-lysine salts and sodium salts. What formed the salt with an inorganic base may be used.
- the external preparation of the present invention is not particularly limited as long as it can administer the active ingredient directly to the local surface of the skin, and examples thereof include ointments, ointment patches, liquids (suspension, emulsion, lotion, etc.), and patches. Preparations, such as powders, tapes, external powders, and aerosols.
- any compounding ingredients used in ordinary external preparations can be used.
- Preservatives such as lahydroxybenzoic acid ester, humectants such as glycerin, propylene dalicol, sodium hyaluronate, polyoxetylene derivatives, glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester , Lecithin and other surfactants, carboxybutyl polymer, xanthan gum, canoleboxymethinoresenorelose, carboxymethylcellulose sodium salt, hydroxypropylcellulose, hydroxypro Thickeners such as pill methyl cellulose, liquefied petroleum gas, liquefied carbon dioxide, dimethyl ether, nitrogen, kerosene, carbon dioxide, and other propellants, stabilizers, preservatives, absorption enhancers, and other suitable additives. Can be blended.
- humectants such as glycerin, propylene dalicol, sodium hyaluron
- tackifiers such as polyacrylic acid and polyacrylic acid copolymer; cross-linking agents such as aluminum sulfate, potassium aluminum sulfate, aluminum chloride, magnesium metasilicate, dihydroxy aluminum acetate, etc.
- glycerin polyethylene glycolone (Mac Goal;), propylene glycolone, polyvalent alcohols such as 1,3-butanediol, surfactants such as polyoxyethylene derivatives, and menthol Fragrances, such as Preservatives such as lahydroxybenzoate, purified water and the like, or other suitable carotenoids may be added.
- Mac Goal polyethylene glycolone
- propylene glycolone polyvalent alcohols such as 1,3-butanediol
- surfactants such as polyoxyethylene derivatives
- menthol Fragrances such as Preservatives such as lahydroxybenzoate, purified water and the like, or other suitable carotenoids
- adhesives such as styrene-isoprene-styrene block copolymer acrylic resin, tackifying resins such as alicyclic saturated hydrocarbon resin, rosin resin, terpene resin, liquid Softeners such as rubber and liquid paraffin; acid inhibitors such as dibutynolehydroxytoluene; polyhydric alcohols such as propylene glycol; absorption promoters such as oleic acid; surfactants such as polyoxetylene derivatives; Alternatively, other suitable additives can be blended.
- sodium polyacrylate A water-containing tape can be prepared by adding a water-containing polymer such as water or polybutyl alcohol and a small amount of purified water.
- an excipient such as potato starch, rice starch, corn starch, talc, zinc oxide or other suitable additives can be blended.
- Antioxidants preservatives such as parahydroxybenzoate, humectants such as glycerin, propylene glycol, sodium hyaluronate, polyoxetylene derivatives, glycerin fatty acid esters, sucrose fatty acid esters, sorbitan fatty acid esters , Propylene glycol fatty acid esters, surfactants such as lecithin, carboxyvinyl polymers, xanthan gum, carboxymethylcellulose, carboxymethylcellulose sodium salts, thickeners such as hydroxypropylcellulose, hydroxypropylmethylcellulose, etc.
- humectants such as glycerin, propylene glycol, sodium hyaluronate
- polyoxetylene derivatives glycerin fatty acid esters
- sucrose fatty acid esters sucrose fatty acid esters
- sorbitan fatty acid esters sorbitan fatty acid esters
- Propylene glycol fatty acid esters sur
- excipients such as potato starch, rice starch, corn starch, talc, zinc oxide, liquefied petroleum gas, liquefied carbon dioxide, dimethyl ether, nitrogen, kerosene, carbon dioxide, etc.
- buffers flavoring agents, suspending agents, emulsifying agents, fragrances, preservatives, solubilizers or may be blended with other suitable additives.
- the external preparation of the present invention is produced using a usual method for producing an external preparation, such as well kneading each component and a base as necessary, and is applied directly to the affected area, or applied and impregnated on a cloth or the like. It is used by a normal use method such as applying.
- fats, fatty oils, lanolin, waxes, resins, plastics, Glycols, higher alcohols, glycerin, water, emulsifiers, suspending agents or other suitable additives as raw materials or based on these, add active ingredients, mix and equalize quality
- additives such as absorption promoter, antioxidant, preservative, surfactant, purified water, etc.
- the raw material base is heated and melted, mixed, and cooled halfway, and then the active ingredients other than the base are liquid or finely powdered and mixed with a part of the base. Add the remaining base, stir and knead until uniform in quality.
- the solid base is dissolved in a water bath and then kept at about 75 ° C. Add the product heated to a high temperature and stir to make it uniform in quality.
- the active ingredient is mixed with a plaster mainly composed of a water-soluble polymer having high water retentivity such as gelatin, carmellose sodium, methyl cellulose, and sodium polyatalylate in advance to prepare a support such as a nonwoven fabric.
- a plaster surface is covered with a plastic film such as polyethylene or polypropylene, and cut into a desired size.
- an adhesive such as acryl resin or a tackifier resin such as alicyclic saturated hydrocarbon resin, rosin resin, terpene resin, or liquid rubber on styrene-isoprene-styrene block copolymer
- a softening agent such as liquid paraffin, an absorption enhancer, an antioxidant, etc., dissolve in an organic solvent such as toluene, and mix or stir, or heat and melt and mix and stir the active ingredient in the form of a solution or powder.
- the active ingredient and solvents, emulsifiers, suspending agents, etc. are added to the aqueous liquid to equalize the quality.
- Suspending lotions are made by micronizing the active ingredient, making it easier to wet with water using dariserin or ethanol, and then gradually adding a suspending agent solution or lotion base to the suspension to make it fine. Even out.
- 3 ⁇ 4 Chillon puts the oil-soluble drug and the oil phase in one container, and puts the water phase in another container and heats each.When making oZw emulsion, gradually add the oil phase to the water phase. When making a w / o emulsion, on the other hand, gradually add the aqueous phase to the oil phase and continue mixing until the emulsification is complete and a homogeneous liquid is obtained.
- the active ingredient and additives are dispersed homogeneously in excipients such as potato starch, rice starch, corn starch, talc, zinc oxide.
- excipients such as potato starch, rice starch, corn starch, talc, zinc oxide.
- the active ingredient solution, ointment, cream, gel, suspension, etc. are produced by the above-mentioned method and the like, and filled in a closed container together with liquefied gas or compressed gas.
- Painful skin wounds to be treated by the external preparation of the present invention include, for example, temperature disorders such as burns, burns, burn ulcers, frostbites, tears, abrasions, cuts, stabs, bruises, bites, Trauma such as Bajaja disease, lymphedema, vascular and lymphatic disorders such as leg ulcers, postoperative wounds such as cutaneous wounds and suture wounds, pressure ulcers, pressure ulcers, diabetic ulcers, gangrene, post-herpetic ulcers Ulcers, drug ulcers, stomas, thermal injury, radiation injury, chemical injury, and other skin wounds.
- the oily base was dissolved on a water bath, and then a solvent was added to mix the dissolved or dispersed acetylsilicylic acid.
- a solution prepared by dissolving a water-soluble base in water and heating was added thereto, and the mixture was stirred and kneaded until the quality became uniform to obtain a cream.
- a tackifier resin, a softener, a solvent, an absorption promoter, an antioxidant, etc. were added to the adhesive, dissolved in an organic solvent such as toluene, mixed with stirring, or heated, melted and mixed with stirring.
- Acetylsalicylic acid is added to the mixture and mixed.
- the mixture is spread on release paper. In the case of a dissolvable type, it is spread and dried, then laminated with a flexible support, cut into a desired size, and taped.
- the application time of the drug at this time was 15 hours.
- the control group was kept under the same conditions as the drug administration group during the application time.
- the pain threshold was measured over time after drug removal, and the pain threshold ratio was calculated from the pain threshold before surgery and evaluated.
- Pain threshold ratio pain threshold at measurement / pain threshold before treatment (before surgery) X 100 The results are shown in Table 8.
- an abscission model was prepared. The drug was continuously administered to the affected area for 15 days, and the area of the defect was measured over time.
- Table 9 shows the results.
- Table 10 shows the results. Table 10
- a topical topical aspirin formulation was administered to 15 affected patients (total number of patients), and the degree of pain improvement was examined.
- steroids and non-steroidal anti-inflammatory analgesics are generally said to delay the healing of skin wounds when administered to the skin wound site.
- a delay in healing of the skin wound was observed.
- acetylsalicylic acid or a pharmacologically acceptable derivative or salt thereof as an active ingredient, trauma such as burns, abrasions, lacerations and cut wounds, surgical infections, and postoperative wounds can be obtained. Painful skin with painful skin wounds such as pressure ulcers, temperature disorders, chemical disorders, radiation disorders, vascular and lymphatic disorders, etc. An external preparation for treating a wound can be provided.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA2004800417052A CN1917884A (zh) | 2004-02-16 | 2004-02-16 | 用于治疗疼痛性皮肤创伤的外用制剂 |
US10/589,462 US8658625B2 (en) | 2004-02-16 | 2004-02-16 | External preparation for treating painful skin wound |
PCT/JP2004/001619 WO2005077380A1 (ja) | 2004-02-16 | 2004-02-16 | 有痛性皮膚創傷の治療用外用剤 |
BRPI0418546-3A BRPI0418546A (pt) | 2004-02-16 | 2004-02-16 | preparação externa para tratamento de ferida de pele dolorosa |
CA002554748A CA2554748A1 (en) | 2004-02-16 | 2004-02-16 | External preparation for treating painful skin wound |
EP04711488A EP1716854A4 (en) | 2004-02-16 | 2004-02-16 | EXTERNAL PREPARATION FOR TREATING PAINFUL SKIN WOUNDS |
AU2004315561A AU2004315561B2 (en) | 2004-02-16 | 2004-02-16 | External preparation for treating painful skin wound |
IL177100A IL177100A (en) | 2004-02-16 | 2006-07-26 | External preparation for the treatment of sore skin |
NO20064196A NO20064196L (no) | 2004-02-16 | 2006-09-15 | Utvortes preparat for behandling av smertefulle hudskader |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2004/001619 WO2005077380A1 (ja) | 2004-02-16 | 2004-02-16 | 有痛性皮膚創傷の治療用外用剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005077380A1 true WO2005077380A1 (ja) | 2005-08-25 |
Family
ID=34857531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2004/001619 WO2005077380A1 (ja) | 2004-02-16 | 2004-02-16 | 有痛性皮膚創傷の治療用外用剤 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8658625B2 (ja) |
EP (1) | EP1716854A4 (ja) |
CN (1) | CN1917884A (ja) |
AU (1) | AU2004315561B2 (ja) |
BR (1) | BRPI0418546A (ja) |
CA (1) | CA2554748A1 (ja) |
IL (1) | IL177100A (ja) |
NO (1) | NO20064196L (ja) |
WO (1) | WO2005077380A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004262776A (ja) * | 2003-02-21 | 2004-09-24 | Teikoku Seiyaku Co Ltd | 血管新生促進剤 |
AU2013327649B2 (en) * | 2012-10-02 | 2018-05-31 | Aloe Bioscience, Llc | Decubitus treatment system |
US9999677B1 (en) | 2015-03-07 | 2018-06-19 | Connie D. Starns | Wound healing composition |
MX2015017409A (es) * | 2015-12-16 | 2017-06-15 | GUERRERO GONZÁLEZ Tayde | Composicion farmaceutica para tratamiento de heridas, quemaduras y ulceras cutaneas. |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0784975A1 (en) * | 1995-12-26 | 1997-07-23 | Teikoku Seiyaku Kabushiki Kaisha | Use of acetylsalicylic acid in the manufacture of a drug for the treatment of skin injuries |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4126681A (en) | 1975-12-08 | 1978-11-21 | The Procter & Gamble Company | Topical composition containing acetyl salicylic acid |
US4219548A (en) * | 1978-09-01 | 1980-08-26 | The Procter & Gamble Company | Topical anti-inflammatory composition |
JP3040427B2 (ja) | 1989-05-18 | 2000-05-15 | 帝國製薬株式会社 | 神経痛治療用アスピリン含有軟膏組成物 |
US5874479A (en) | 1991-03-01 | 1999-02-23 | Warner-Lambert Company | Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same |
US5376376A (en) | 1992-01-13 | 1994-12-27 | Li; Shu-Tung | Resorbable vascular wound dressings |
JP3799502B2 (ja) | 1992-12-07 | 2006-07-19 | エル テー エス ローマン テラピー・システーメゲー.エム.ベー.ハー ウント コンパニー カー.ゲー | 抗血栓治療および癌予防のためのアセチルサリチル酸を含有する経皮投与システム |
US5487899A (en) | 1994-01-31 | 1996-01-30 | Jess Clarke & Sons, Inc. | Wound healing |
US5932230A (en) | 1997-05-20 | 1999-08-03 | Degrate; Frenchell | Topical analgesic formulation containing fruits, oils and aspirin |
JPH1112177A (ja) * | 1997-06-25 | 1999-01-19 | Teikoku Seiyaku Co Ltd | 安定なアスピリン含有外用製剤 |
US6284797B1 (en) * | 1999-04-12 | 2001-09-04 | Donald A. Rhodes | Topical treatment of pain and to promote healing |
ES2304989T3 (es) | 1999-12-28 | 2008-11-01 | Teikoku Seiyaku Co., Ltd. | Agente antiprurigonoso para uso externo. |
JP2001187739A (ja) | 1999-12-28 | 2001-07-10 | Teikoku Seiyaku Co Ltd | アレルギー性皮膚疾患治療用外用剤 |
DE60128673D1 (de) * | 2000-03-17 | 2007-07-12 | Avocet Polymer Technologies In | Verfahren zur verbesserung der grösse und des aussehens einer wunde |
US20030232094A1 (en) | 2002-06-12 | 2003-12-18 | Fuller Peter E. | Composition and method for the treatment of skin irritations |
US20060045858A1 (en) | 2004-08-26 | 2006-03-02 | Fuller Peter E | Composition and method for reducing harmful effects of ultraviolet radiation impinging on the skin |
-
2004
- 2004-02-16 AU AU2004315561A patent/AU2004315561B2/en not_active Ceased
- 2004-02-16 WO PCT/JP2004/001619 patent/WO2005077380A1/ja not_active Application Discontinuation
- 2004-02-16 BR BRPI0418546-3A patent/BRPI0418546A/pt not_active IP Right Cessation
- 2004-02-16 US US10/589,462 patent/US8658625B2/en active Active
- 2004-02-16 EP EP04711488A patent/EP1716854A4/en not_active Withdrawn
- 2004-02-16 CN CNA2004800417052A patent/CN1917884A/zh active Pending
- 2004-02-16 CA CA002554748A patent/CA2554748A1/en not_active Abandoned
-
2006
- 2006-07-26 IL IL177100A patent/IL177100A/en active IP Right Grant
- 2006-09-15 NO NO20064196A patent/NO20064196L/no not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0784975A1 (en) * | 1995-12-26 | 1997-07-23 | Teikoku Seiyaku Kabushiki Kaisha | Use of acetylsalicylic acid in the manufacture of a drug for the treatment of skin injuries |
Also Published As
Publication number | Publication date |
---|---|
AU2004315561A1 (en) | 2005-08-25 |
CA2554748A1 (en) | 2005-08-25 |
AU2004315561B2 (en) | 2010-10-28 |
EP1716854A1 (en) | 2006-11-02 |
US20070197483A1 (en) | 2007-08-23 |
BRPI0418546A (pt) | 2007-05-22 |
IL177100A (en) | 2015-10-29 |
US8658625B2 (en) | 2014-02-25 |
NO20064196L (no) | 2006-11-14 |
IL177100A0 (en) | 2006-12-10 |
EP1716854A4 (en) | 2010-01-20 |
CN1917884A (zh) | 2007-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TWI510235B (zh) | 消炎鎮痛外用劑 | |
WO1996004902A1 (fr) | Composition pour preparation a usage externe | |
JPH06205839A (ja) | 経皮投与型薬物用貼付剤 | |
JPS62181226A (ja) | 消炎鎮痛外用剤 | |
JP4813725B2 (ja) | 鎮痒用外用剤 | |
WO2005077380A1 (ja) | 有痛性皮膚創傷の治療用外用剤 | |
ZA200506286B (en) | Therapeutic agent for hemorrhoidal disease | |
JP4868687B2 (ja) | ケロイド等の形成抑制外用剤 | |
JP2004137215A (ja) | 有痛性皮膚創傷の治療用外用剤 | |
JPH06145053A (ja) | 使用性の改善された消炎鎮痛用皮膚外用貼付剤 | |
WO2001047526A1 (fr) | Medicaments a usage externe pour manifestations allergiques de la peau | |
JP4313003B2 (ja) | 血液透析による皮膚疾患及び痒みの治療用外用剤 | |
JP2004292341A (ja) | ケロイド等の形成抑制外用剤 | |
KR20060130651A (ko) | 통증이 있는 피부 창상의 치료용 외용제 | |
WO2005077379A1 (ja) | ウイルス感染による皮膚・粘膜傷害症状に対する外用治療剤 | |
JP2004137216A (ja) | ウイルス感染による皮膚・粘膜傷害症状に対する外用治療剤 | |
JPH06145047A (ja) | 使用性の改善された含水性皮膚外用貼付剤 | |
ZA200606352B (en) | External preparation for treating painful skin wound | |
JPH07223949A (ja) | 消炎鎮痛外用剤 | |
MXPA06009275A (en) | External preparation for treating painful skin wound | |
ZA200606351B (en) | Remedy for external use for skin and mucosal injuries caused by viral infection | |
MXPA06009302A (en) | Remedy for external use for skin and mucosal injuries caused by viral infection | |
KR20060123530A (ko) | 바이러스 감염에 의한 피부 및 점막 상해에 대한외용치료제 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
DPEN | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 177100 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2554748 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004315561 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006/06352 Country of ref document: ZA Ref document number: 200606352 Country of ref document: ZA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004711488 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020067016141 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10589462 Country of ref document: US Ref document number: 2007197483 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2006/009275 Country of ref document: MX Ref document number: 200480041705.2 Country of ref document: CN Ref document number: 549208 Country of ref document: NZ |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: DE |
|
ENP | Entry into the national phase |
Ref document number: 2004315561 Country of ref document: AU Date of ref document: 20040216 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2004315561 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 2004711488 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1020067016141 Country of ref document: KR |
|
ENP | Entry into the national phase |
Ref document number: PI0418546 Country of ref document: BR |
|
WWP | Wipo information: published in national office |
Ref document number: 10589462 Country of ref document: US |