WO2005042703A3 - Cellules souches placentaires et utilisations associees - Google Patents

Cellules souches placentaires et utilisations associees Download PDF

Info

Publication number
WO2005042703A3
WO2005042703A3 PCT/US2004/034966 US2004034966W WO2005042703A3 WO 2005042703 A3 WO2005042703 A3 WO 2005042703A3 US 2004034966 W US2004034966 W US 2004034966W WO 2005042703 A3 WO2005042703 A3 WO 2005042703A3
Authority
WO
WIPO (PCT)
Prior art keywords
placental stem
stem cells
cells
cardiomyocytes
hepatocytes
Prior art date
Application number
PCT/US2004/034966
Other languages
English (en)
Other versions
WO2005042703A2 (fr
Inventor
Stephen C Strom
Miki Toshio
Original Assignee
M Of Higher Education Universi
Stephen C Strom
Miki Toshio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by M Of Higher Education Universi, Stephen C Strom, Miki Toshio filed Critical M Of Higher Education Universi
Priority to CA002543528A priority Critical patent/CA2543528A1/fr
Priority to EP04796030A priority patent/EP1689854A4/fr
Publication of WO2005042703A2 publication Critical patent/WO2005042703A2/fr
Publication of WO2005042703A3 publication Critical patent/WO2005042703A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/148—Transforming growth factor alpha [TGF-a]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne de nouvelles cellules souches placentaires ainsi que des méthodes et des compositions permettant des utilisations thérapeutiques de cellules souches placentaires ou de cellules souches placentaires qui ont été amenées à se différencier en un type de tissu différent chez un hôte receveur en quantités suffisantes pour entraîner la production du type cellulaire souhaité, par exemple, des hépatocytes, des cellules nerveuses, des cellules pancréatiques, des cellules endothéliales vasculaires, des cardiomyocytes.
PCT/US2004/034966 2003-10-22 2004-10-22 Cellules souches placentaires et utilisations associees WO2005042703A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002543528A CA2543528A1 (fr) 2003-10-22 2004-10-22 Cellules souches placentaires et utilisations associees
EP04796030A EP1689854A4 (fr) 2003-10-22 2004-10-22 Cellules souches placentaires et utilisations associees

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/691,468 US20040161419A1 (en) 2002-04-19 2003-10-22 Placental stem cells and uses thereof
US10/691,468 2003-10-22

Publications (2)

Publication Number Publication Date
WO2005042703A2 WO2005042703A2 (fr) 2005-05-12
WO2005042703A3 true WO2005042703A3 (fr) 2006-06-22

Family

ID=34549883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/034966 WO2005042703A2 (fr) 2003-10-22 2004-10-22 Cellules souches placentaires et utilisations associees

Country Status (4)

Country Link
US (1) US20040161419A1 (fr)
EP (1) EP1689854A4 (fr)
CA (1) CA2543528A1 (fr)
WO (1) WO2005042703A2 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691217B2 (en) 2005-12-29 2014-04-08 Anthrogenesis Corporation Placental stem cell populations
US8895256B2 (en) 2005-10-13 2014-11-25 Anthrogenesis Corporation Immunomodulation using placental stem cells
US8916146B2 (en) 2007-02-12 2014-12-23 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
US8926964B2 (en) 2010-07-13 2015-01-06 Anthrogenesis Corporation Methods of generating natural killer cells
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
US9121007B2 (en) 2010-01-26 2015-09-01 Anthrogenesis Corporatin Treatment of bone-related cancers using placental stem cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US9139813B2 (en) 2001-02-14 2015-09-22 Anthrogenesis Corporation Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
US9149569B2 (en) 2000-12-06 2015-10-06 Anthrogenesis Corporation Treatment of diseases or disorders using placental stem cells
US9175261B2 (en) 2005-12-16 2015-11-03 DePuy Synthes Products, Inc. Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation
US9198938B2 (en) 2008-11-19 2015-12-01 Antrhogenesis Corporation Amnion derived adherent cells
US9216200B2 (en) 2007-09-28 2015-12-22 Anthrogenesis Corporation Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9254302B2 (en) 2010-04-07 2016-02-09 Anthrogenesis Corporation Angiogenesis using placental stem cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473555B2 (en) 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
JP2006509770A (ja) 2002-11-26 2006-03-23 アンソロジェネシス コーポレーション 細胞治療学、細胞治療単位、およびそれらを利用した治療法
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
JP2007536935A (ja) 2004-05-14 2007-12-20 ベクトン・ディキンソン・アンド・カンパニー 間葉幹細胞の無血清増殖のための細胞培養環境
JP2006006249A (ja) * 2004-06-28 2006-01-12 Hiroshima Univ 羊膜由来細胞の培養方法及びその利用
AU2012202529B2 (en) * 2004-07-09 2015-04-02 Viacyte, Inc. Preprimitive streak and mesendoderm cells
PL1789534T3 (pl) 2004-08-16 2015-03-31 Cellresearch Corp Pte Ltd Wyodrębnienie komórek macierzystych/progenitorowych z błony owodniowej pępowiny
WO2006034873A1 (fr) * 2004-09-29 2006-04-06 Cellartis Ab Generation de cellules hepatocytaires a partir de souches derivant de blastocytes humains (hbs)
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
AU2005322068B2 (en) 2004-12-23 2011-09-01 Ethicon Incorporated Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells
US20100028306A1 (en) * 2005-03-31 2010-02-04 Stemnion, Inc. Amnion-Derived Cell Compositions, Methods of Making and Uses Thereof
US20060222634A1 (en) 2005-03-31 2006-10-05 Clarke Diana L Amnion-derived cell compositions, methods of making and uses thereof
DK1864132T3 (da) * 2005-03-31 2012-07-16 Stemnion Inc Fra amnion stammende cellesammensætninger, fremgangsmåder til fremstilling deraf og anvendelser deraf
US8153430B2 (en) * 2005-03-31 2012-04-10 Stemnion, Inc. Methods related to surgery
AU2006202209B2 (en) 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
PL1888123T3 (pl) * 2005-06-08 2013-06-28 Janssen Biotech Inc Terapia komórkowa chorób degeneracyjnych oka
US8071376B2 (en) * 2005-10-13 2011-12-06 Anthrogenesis Corporation Production of oligodendrocytes from placenta-derived stem cells
US7534607B1 (en) * 2005-12-27 2009-05-19 Industrial Technology Research Institute Method of producing cardiomyocytes from mesenchymal stem cells
ES2628129T3 (es) * 2005-12-28 2017-08-01 DePuy Synthes Products, Inc. Tratamiento de la enfermedad vascular periférica utilizando células derivadas del posparto
ZA200804718B (en) 2005-12-29 2010-04-28 Anthrogenesis Corp Co-culture of placental stem cells and stem cells from a second source
US8871198B2 (en) 2006-03-29 2014-10-28 Stemnion, Inc. Methods related to wound healing
US7727763B2 (en) * 2006-04-17 2010-06-01 Bioe, Llc Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
US8741643B2 (en) * 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
KR100792184B1 (ko) * 2006-05-12 2008-01-07 재단법인서울대학교산학협력재단 개의 제대혈, 태반 및 개 태아의 심장 유래 다분화능 성체줄기세포, 그 제조방법 및 이를 함유하는 세포 치료제
EP2024492B1 (fr) 2006-06-02 2017-03-29 Asterias Biotherapeutics, Inc. Différentiation de cellules pluripotentes de primates en cellules de lignées hépatocytaires
US20080064098A1 (en) * 2006-06-05 2008-03-13 Cryo-Cell International, Inc. Procurement, isolation and cryopreservation of maternal placental cells
US20080050814A1 (en) * 2006-06-05 2008-02-28 Cryo-Cell International, Inc. Procurement, isolation and cryopreservation of fetal placental cells
CN101501185A (zh) * 2006-06-09 2009-08-05 人类起源公司 胎盘巢(placental niche)及其培养干细胞的用途
US8475788B2 (en) 2006-06-14 2013-07-02 Stemnion, Inc. Methods of treating spinal cord injury and minimizing scarring
WO2007145889A1 (fr) 2006-06-14 2007-12-21 Stemnion, Inc. Procédés pour traiter une lésion de la moelle épinière et pour minimiser l'étendue de la cicatrisation
EP2089510B1 (fr) * 2006-06-28 2021-02-24 The University of Medicine and Dentistry of New Jersey Cellules souches dérivées d'amnios et utilisations de celles-ci
US7993918B2 (en) * 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
US8562972B2 (en) * 2006-10-23 2013-10-22 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
EP2118267B1 (fr) 2007-01-17 2017-03-15 Noveome Biotherapeutics, Inc. Nouveaux procédés pour moduler des réponses inflammatoires et/ou immunitaires
CN101688177A (zh) * 2007-02-12 2010-03-31 人类起源公司 来自贴壁胎盘干细胞的肝细胞和软骨细胞；以及cd34+、cd45-胎盘干细胞富集的细胞群
WO2009008928A2 (fr) 2007-04-13 2009-01-15 Stemnion, Inc. Procédés pour le traitement d'une lésion et d'une maladie du système nerveux
JP5567476B2 (ja) * 2007-05-28 2014-08-06 モナッシュ ユニバーシティ 慢性肺疾患の治療
JP5597129B2 (ja) 2007-06-18 2014-10-01 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド 胎盤由来の幹細胞および前駆体細胞の単離方法
US9080145B2 (en) * 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
CN101835479A (zh) * 2007-07-25 2010-09-15 佰欧益有限公司 多系祖细胞分化为软骨细胞
EP2185693B1 (fr) 2007-07-31 2019-07-03 Lifescan, Inc. Différenciation de cellules souches embryonnaires humaines
SI2200622T2 (sl) 2007-09-19 2015-09-30 Pluristem Ltd. Adherentne celice iz adipoznih ali placentnih tkiv in njihova uporaba pri terapiji
EP2229434B1 (fr) * 2007-11-27 2011-09-07 Lifescan, Inc. Différentiation des cellules souches embryonnaires humaines
CA2959401C (fr) 2008-02-21 2021-12-07 Centocor Ortho Biotech Inc. Procedes, plaques a surface modifiee et compositions permettant la fixation, la culture et le detachement de cellules
US8623648B2 (en) * 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
US20090291494A1 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of Multi-Lineage Progenitor Cells to Pancreatic Cells
WO2010002785A1 (fr) * 2008-06-30 2010-01-07 Centocor Ortho Biotech Inc. Différenciation de cellules souches pluripotentes
EP2310492B1 (fr) 2008-06-30 2015-07-22 Janssen Biotech, Inc. Différenciation de cellules souches pluripotentes
US20100028307A1 (en) * 2008-07-31 2010-02-04 O'neil John J Pluripotent stem cell differentiation
CA2734237C (fr) 2008-08-20 2019-07-02 Anthrogenesis Corporation Traitement d'un accident vasculaire cerebral a l'aide de cellules placentaires isolees
KR20200011604A (ko) 2008-08-20 2020-02-03 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
AU2009283161A1 (en) 2008-08-22 2010-02-25 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
CN101889079B (zh) * 2008-10-17 2012-08-08 宁夏医科大学附属医院 适于临床应用的人胎盘间质细胞库的建立方法
CA2742268C (fr) * 2008-10-31 2020-02-18 Centocor Ortho Biotech Inc. Differenciation de cellules souches embryonnaires humaines en la lignee endocrine pancreatique
US9012218B2 (en) * 2008-10-31 2015-04-21 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
AU2009316583B2 (en) * 2008-11-20 2016-04-21 Janssen Biotech, Inc. Methods and compositions for cell attachment and cultivation on planar substrates
RU2555538C2 (ru) 2008-11-20 2015-07-10 Сентокор Орто Байотек Инк. Культура плюрипотентных стволовых клеток на микроносителях
AU2009324641A1 (en) * 2008-12-10 2011-07-28 University Of Louisville Research Foundation, Inc. Somatic cell-derived pluripotent cells and methods of use therefor
CN101748096B (zh) * 2008-12-17 2013-03-13 北京汉氏联合生物技术有限公司 亚全能干细胞、其制备方法及其用途
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
ES2665883T3 (es) 2008-12-19 2018-04-30 DePuy Synthes Products, Inc. Tratamiento de enfermedades y trastornos pulmonares y pulmonares
US8771677B2 (en) 2008-12-29 2014-07-08 Vladimir B Serikov Colony-forming unit cell of human chorion and method to obtain and use thereof
BRPI1013409A2 (pt) 2009-03-26 2018-01-16 Advanced Tech And Regenerative Medicine Llc células de tecido de cordão umbilical humano como terapia para doença de alzheimer
FI20095409A0 (fi) * 2009-04-14 2009-04-14 Helsingin Yliopisto Soluviljelysupplementti
US8647617B2 (en) 2009-07-13 2014-02-11 Stemnion, Inc. Methods for modulating inflammatory and/or immune responses
GB2485113B (en) * 2009-07-20 2016-12-28 Janssen Biotech Inc Differentiation of human embryonic stem cells into cells of the pancreatic endoderm lineage
CN102482640B (zh) * 2009-07-20 2015-03-11 詹森生物科技公司 人胚胎干细胞的分化
BR112012001480A2 (pt) 2009-07-20 2015-09-01 Janssen Biotech Inc Diferenciação de células-tronco embriônicas humanas
RU2664864C1 (ru) * 2009-12-23 2018-08-23 Янссен Байотек, Инк. Способы увеличения экспрессии ngn3 и nkx6.1 в эндокринных клетках поджелудочной железы
US9150833B2 (en) 2009-12-23 2015-10-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
WO2011109279A2 (fr) * 2010-03-01 2011-09-09 Centocor Ortho Biotech Inc. Procédés de purification de cellules issues de cellules souches pluripotentes
WO2011127113A1 (fr) 2010-04-08 2011-10-13 Anthrogenesis Corporation Traitement de la sarcoïdose au moyen de cellules souches du sang placentaire
CN102884176B (zh) 2010-05-12 2017-09-05 詹森生物科技公司 人胚胎干细胞的分化
US8454957B2 (en) 2010-06-17 2013-06-04 Stemnion, Inc. Methods for treating coagulation disorders
CN101914488B (zh) * 2010-08-04 2014-08-27 北京科润维德生物技术有限责任公司 将人羊膜间充质细胞诱导分化成胰岛分泌细胞的方法
PL2611909T3 (pl) 2010-08-31 2018-05-30 Janssen Biotech, Inc Zróżnicowanie ludzkich embrionalnych komórek macierzystych
PL2611910T3 (pl) 2010-08-31 2018-06-29 Janssen Biotech, Inc Różnicowanie ludzkich embrionalnych komórek macierzystych
RU2673946C1 (ru) 2010-08-31 2018-12-03 Янссен Байотек, Инк. Дифференцирование плюрипотентных стволовых клеток
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US8574899B2 (en) 2010-12-22 2013-11-05 Vladimir B Serikov Methods for augmentation collection of placental hematopoietic stem cells and uses thereof
CN113559126A (zh) 2011-06-01 2021-10-29 人类起源公司 利用胎盘干细胞治疗疼痛
WO2013055476A1 (fr) 2011-09-09 2013-04-18 Anthrogenesis Corporation Traitement de la sclérose latérale amyotrophique au moyen de cellules souches placentaires
BR112014015417A8 (pt) 2011-12-22 2017-07-04 Janssen Biotech Inc diferenciação de células-tronco embrionárias humanas em células positivas de insulina hormonal únicas
CA2869681A1 (fr) 2011-12-23 2013-06-27 Advanced Technologies And Regenerative Medicine, Llc Detection de cellules extraites du tissu du cordon ombilical chez l'homme
AU2013230020B2 (en) 2012-03-07 2018-08-09 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
CN104334719B (zh) 2012-06-08 2018-02-13 詹森生物科技公司 人胚胎干细胞向胰腺内分泌细胞的分化
AU2013248265B2 (en) * 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
MX2015008619A (es) 2012-12-31 2016-01-12 Janssen Biotech Inc Suspension y agrupamiento de celulas humanas pluripotentes para la diferenciacion a celulas endocrinas pancreaticas.
MX2015008578A (es) 2012-12-31 2015-09-07 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9.
RU2018116647A (ru) 2012-12-31 2018-10-24 Янссен Байотек, Инк. Культивация эмбриональных стволовых клеток человека в воздушно-жидкостной зоне взаимодействия с целью их дифференцировки в панкреатические эндокринные клетки
EP3622960A1 (fr) 2013-02-05 2020-03-18 Celularity, Inc. Cellules tueuses naturelles placentaires
WO2014129792A1 (fr) * 2013-02-20 2014-08-28 사회복지법인 삼성생명공익재단 Composition pour le traitement de maladies inflammatoires du cerveau comprenant une cellule souche comme principe actif
EP2968402B1 (fr) 2013-03-13 2020-07-15 Noveome Biotherapeutics, Inc. Dispositifs medicaux avec un revetement contenant accs
TW201522637A (zh) * 2013-03-15 2015-06-16 Jackson Lab 非胚胎幹細胞之單離及其用途
WO2014143943A1 (fr) 2013-03-15 2014-09-18 NuTech Spine, Inc. Préparations contenant un facteur de croissance hépatocytaire et de l'acide hyaluronique et procédés de fabrication et d'utilisation associés
US20160193250A1 (en) * 2013-05-30 2016-07-07 Cells For Cells Chorion-derived mscs cells and conditioned media as inducer for angiogenesis application for the treatment of cardiac degeneration.
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3613841B1 (fr) 2014-03-25 2022-04-20 Terumo BCT, Inc. Remplacement passif de supports
US11083758B2 (en) 2014-05-14 2021-08-10 Prime Merger Sub, Llc Placental membrane preparations and methods of making and using same for regenerating cartilage and spinal intervertebral discs
RU2694311C2 (ru) 2014-05-16 2019-07-11 Янссен Байотек, Инк. Применение малых молекул для увеличения экспрессии mafa в панкреатических эндокринных клетках
EP3198006B1 (fr) 2014-09-26 2021-03-24 Terumo BCT, Inc. Alimentation programmée
WO2017004592A1 (fr) 2015-07-02 2017-01-05 Terumo Bct, Inc. Croissance cellulaire à l'aide de stimuli mécaniques
CA2998759A1 (fr) * 2015-09-15 2017-03-23 Celularity Inc. Traitement de la neuropathie peripherique diabetique au moyen de cellules placentaires
CN106609258A (zh) * 2015-10-23 2017-05-03 江苏齐氏生物科技有限公司 一种大鼠鼻粘膜上皮细胞分离及培养方法
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11419899B2 (en) 2016-07-29 2022-08-23 Tohoku University Method of treating aortic aneurysm using muse cells
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656842A1 (fr) 2017-03-31 2020-05-27 Terumo BCT, Inc. Expansion de cellules
WO2019040790A1 (fr) * 2017-08-23 2019-02-28 Merakris Therapeutics, Llc Compositions contenant des composants amniotiques et leurs procédés de préparation et d'utilisation
KR102224273B1 (ko) * 2019-10-10 2021-03-08 고려대학교 산학협력단 줄기세포 유래 성숙 심근세포 및 이를 이용한 심혈관 질환 모델

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999020741A1 (fr) * 1997-10-23 1999-04-29 Geron Corporation Procedes et matieres utiles pour la croissance de cellules souches primordiales de primate
WO2000073421A2 (fr) * 1999-06-02 2000-12-07 Lifebank Services, L.L.C. Methodes d'isolement, de cryopreservation, et d'utilisation therapeutique de cellules epitheliales amniotiques humaines
US20020151053A1 (en) * 2000-01-11 2002-10-17 Carpenter Melissa K. Direct differentiation of human pluripotent stem cells and characterization of differentiated cells
WO2003042405A2 (fr) * 2001-11-15 2003-05-22 Children's Medical Center Corporation Techniques d'isolation, de developpement et de differenciation de cellules souches provenant de villosites choriales, de liquide amniotique ainsi que de placenta et applications therapeutiques
US20030180269A1 (en) * 2002-02-13 2003-09-25 Hariri Robert J. Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002A (en) * 1841-03-12 Tor and planter for plowing
GB8803697D0 (en) * 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells
WO1994027622A1 (fr) * 1993-05-24 1994-12-08 The Johns Hopkins University Tolerogenese de substitution destinee au developpement de la tolerance aux xenogreffes
MX9701512A (es) * 1994-11-16 1997-05-31 Amgen Inc Uso del factor de celulas madre y receptor de interleucina-6 soluble para la expansion ex vivo de celulas multipotenciales hematopoyeticas.
US6117676A (en) * 1995-07-27 2000-09-12 Srl, Inc. Transfected human amniotic cells and method for producing a gene product
EP1064353B1 (fr) * 1998-03-18 2002-11-06 Massachusetts Institute Of Technology Ensemble de micro-tissus et de micro-organes vascularises et perfuses
US6395546B1 (en) * 2000-02-01 2002-05-28 Neurogeneration, Inc. Generation of dopaminergic neurons from human nervous system stem cells
EP1288293A1 (fr) * 2001-08-30 2003-03-05 Norio Sakuragawa Cellules souches neuronales humaines originaires d'une couche de cellules mesenchymateuses amniotiques humaines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999020741A1 (fr) * 1997-10-23 1999-04-29 Geron Corporation Procedes et matieres utiles pour la croissance de cellules souches primordiales de primate
WO2000073421A2 (fr) * 1999-06-02 2000-12-07 Lifebank Services, L.L.C. Methodes d'isolement, de cryopreservation, et d'utilisation therapeutique de cellules epitheliales amniotiques humaines
US20020151053A1 (en) * 2000-01-11 2002-10-17 Carpenter Melissa K. Direct differentiation of human pluripotent stem cells and characterization of differentiated cells
WO2003042405A2 (fr) * 2001-11-15 2003-05-22 Children's Medical Center Corporation Techniques d'isolation, de developpement et de differenciation de cellules souches provenant de villosites choriales, de liquide amniotique ainsi que de placenta et applications therapeutiques
US20030180269A1 (en) * 2002-02-13 2003-09-25 Hariri Robert J. Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9149569B2 (en) 2000-12-06 2015-10-06 Anthrogenesis Corporation Treatment of diseases or disorders using placental stem cells
US9139813B2 (en) 2001-02-14 2015-09-22 Anthrogenesis Corporation Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US8895256B2 (en) 2005-10-13 2014-11-25 Anthrogenesis Corporation Immunomodulation using placental stem cells
US9539288B2 (en) 2005-10-13 2017-01-10 Anthrogenesis Corporation Immunomodulation using placental stem cells
US9175261B2 (en) 2005-12-16 2015-11-03 DePuy Synthes Products, Inc. Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US9585918B2 (en) 2005-12-28 2017-03-07 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US8691217B2 (en) 2005-12-29 2014-04-08 Anthrogenesis Corporation Placental stem cell populations
US8916146B2 (en) 2007-02-12 2014-12-23 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
US9216200B2 (en) 2007-09-28 2015-12-22 Anthrogenesis Corporation Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
US9198938B2 (en) 2008-11-19 2015-12-01 Antrhogenesis Corporation Amnion derived adherent cells
US9121007B2 (en) 2010-01-26 2015-09-01 Anthrogenesis Corporatin Treatment of bone-related cancers using placental stem cells
US9254302B2 (en) 2010-04-07 2016-02-09 Anthrogenesis Corporation Angiogenesis using placental stem cells
US9464274B2 (en) 2010-07-13 2016-10-11 Anthrogenesis Corporation Methods of generating natural killer cells
US8926964B2 (en) 2010-07-13 2015-01-06 Anthrogenesis Corporation Methods of generating natural killer cells
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules

Also Published As

Publication number Publication date
WO2005042703A2 (fr) 2005-05-12
EP1689854A4 (fr) 2007-01-24
EP1689854A2 (fr) 2006-08-16
US20040161419A1 (en) 2004-08-19
CA2543528A1 (fr) 2005-05-12

Similar Documents

Publication Publication Date Title
WO2005042703A3 (fr) Cellules souches placentaires et utilisations associees
WO2003089619A3 (fr) Cellules souches placentaires et utilisations
WO2007030743A3 (fr) Implants cochleaires contenant des cellules biologiques et utilisations de ces dernieres
WO2005030121A3 (fr) Composes, compositions et procedes
WO2008057459A3 (fr) Antagonistes de pcsk9
WO2008057457A3 (fr) Antagonistes de pcsk9
WO2008057458A3 (fr) Antagonistes de pcsk9
WO2008133647A3 (fr) Antagonistes de pcsk9
WO2005001079A3 (fr) Reparation et regeneration des tissus mous a l'aide de cellules provenant de tissus post-partum
WO2005085422A8 (fr) Cellules souches adultes et leurs utilisations
WO2007067682A3 (fr) Modification in vivo de surfaces cellulaires
WO2007149861A3 (fr) Réparation de tissu mou et régénération à l'aide des produits de cellules souches
EP1302536A3 (fr) Cellules souches embryonnaires et cellules progénitrices neuronales dérivées de celles-ci
WO2003080801A3 (fr) Cellules souches stromales issues de tissu adipeux, utiles pour la modification de tissus et de vaisseaux
WO2007030652A3 (fr) Methodes et compositions pour cultiver des cellules souches adipeuses
WO2006053227A3 (fr) Composes modulateurs de la il-12
WO2006015887A3 (fr) Modulation de biosynthèse alcaloïdique des plantes et plantes à biosynthèse alcaloïdique altérée
WO2005099770A3 (fr) Micro-arn d'ilot pancreatique et methodes permettant d'inhiber ce dernier
WO2006018836A3 (fr) Constructions d'acides nucleiques et cellules, et methodes faisant appel a ces dernieres pour modifier la fonction electrophysiologique de tissus excitables
WO2005118824A8 (fr) Methodes et compositions inhibant l'expression genique
EP1627047A4 (fr) Methodes permettant de faciliter la recuperation de fonctions de cellules souches endogenes, implantees ou transplantees au moyen d'un acide hyaluronique de poids moleculaire eleve
WO2006060680A3 (fr) Variants de la proteine mda-7 presentant une activite antiproliferative
WO2006063055A3 (fr) Conjugues enzymatiques utilises en tant qu'agents detoxifiants
GB2453068A (en) Novel hepatocyte-like cells and hepatoblast-like cells derived from hbs cells
WO2003091398A3 (fr) Compositions et techniques d'apport de cellules embryonnaires

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2543528

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004796030

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004796030

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2004796030

Country of ref document: EP