WO2005027636A2 - Traitement topique ameliore pour l'eradication et/ou la lutte contre des ectoparasites - Google Patents

Traitement topique ameliore pour l'eradication et/ou la lutte contre des ectoparasites Download PDF

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Publication number
WO2005027636A2
WO2005027636A2 PCT/GB2004/004037 GB2004004037W WO2005027636A2 WO 2005027636 A2 WO2005027636 A2 WO 2005027636A2 GB 2004004037 W GB2004004037 W GB 2004004037W WO 2005027636 A2 WO2005027636 A2 WO 2005027636A2
Authority
WO
WIPO (PCT)
Prior art keywords
ectoparasites
fluid
alcohol
control
lice
Prior art date
Application number
PCT/GB2004/004037
Other languages
English (en)
Other versions
WO2005027636A3 (fr
Inventor
Ian Peter Whelan
Original Assignee
Entomos Research Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0322118A external-priority patent/GB0322118D0/en
Priority claimed from GB0322117A external-priority patent/GB0322117D0/en
Application filed by Entomos Research Limited filed Critical Entomos Research Limited
Publication of WO2005027636A2 publication Critical patent/WO2005027636A2/fr
Publication of WO2005027636A3 publication Critical patent/WO2005027636A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin

Definitions

  • This invention relates to an improved topical treatment for "the eradication and/or control of ectoparasites, and particularly arthropods, and to compositions for use in such treatment .
  • Ectoparasites are widely present on many animal species. The ⁇ nfestations can spread easily in groups of animals. This may occur through direct transfer of ectoparasites from animal to animal when in close proximity. Alternatively the ectoparasite may drop from a host animal to the ground or other object until picked up by a passing animal. In the case of mammals ectoparasites usually dwell in portions of the body which carry hair which provides protection for them.
  • the preferred fatty acids are aliphatic carJ oxylic acids having from 8 to 14 carbon atoms. Acids having an even number of carbon atoms, such as caprylic, capric, lauric and myristic acids, are particularly preferred.
  • the ester is formed from a mono-, di- or tri-hydric alcohol it is preferably an aliphatic alcohol having from three to eight carbon atoms.
  • the most preferred alcohols have three or four carbon atoms such as n-propyl-, iso-propyl-,. n-butyl- or iso-butyl alcohol and provide most effective compounds for treatment such as iso-propyl myristate.
  • esters that may be used in the invention include a mixture of caprylcaproyl macrogol-8 glycerides .
  • a further effective ester is diethylene glycol monoethyl ether.
  • the esters used in the treatment of the present invention are lipophilic.
  • the treatment is particularly effective on mammals. These may include companion animals such as dogs, cats, ferrets, rabbits, gerbils and guinea pigs. Farm animals such as bovine, porcine, ovine and equine species.
  • the treatment may be safely used on Homo sapiens. Many ectoparasites are host specific however the treatment according to the invention is effective against most of them.
  • the treatment may also be used to eradicate and control arthropods such as thrips, white fly, aphids and wood boring and burrowing insects.
  • Topical application on a mammal may comprise direct manual application, painting, spraying or application as a foam or gel.
  • a fluid composition was prepared consisting of 30% by weight caprylcaproyl macrogol-8 glycerides mixed with isopropanol. As a control 60% aqueous isopropanol was used. The tests were performed with one replicate each and with an overnight exposure to the fluid.
  • the ectoparasites were human head lice, Pediculus hu anus, obtained from the culture colony of Insect R&D Limited.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention a trait à un fluide comportant un ou des esters d'acide gras d'un mono-, bi- tri-alcool ou polyol ou un éther d'alkyle inférieur d'un glycol en tant que traitement topique pour l'éradication et/ou la lutte contre des ectoparasites et des arthropodes. De préférence, le fluide est exempt d'une quantité active de tout autre composé d'élimination d'ectoparasites. Des acides gras préférés sont des acides carboxyliques aliphatiques ayant 8 à 14 atomes. Le mono-, di-, tri-alcool est un alcool aliphatique ayant 3 à 8 atomes de carbone pouvant être un n- ou iso-alcool ayant 3 à 4 atomes de carbone. Le fluide peut comprendre un mélange de glycérides de caprylcaproyle macrogol-8 et/ou d'éther monométhylique de diéthyléne glycol. Le fluide peut être appliqué sous la forme d'une mousse ou d'un gel. Les ectoparasites peuvent être des poux de corps, des morpions, des acariens de la gale ou des tiques. L'espèce hôte peut être un mammifères tel qu'un humain et les ectoparasites sont des poux de tête ou des animaux de compagnie, tels que des chiens ou des chats et les ectoparasites sont des puces ou des tiques. Les fluides peuvent également être appliqués aux plantes et au bois.
PCT/GB2004/004037 2003-09-22 2004-09-22 Traitement topique ameliore pour l'eradication et/ou la lutte contre des ectoparasites WO2005027636A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0322118.1 2003-09-22
GB0322118A GB0322118D0 (en) 2003-09-22 2003-09-22 Arthropodicdal compositions
GB0322117A GB0322117D0 (en) 2003-09-22 2003-09-22 Arthropodicdal compositions
GB0322117.3 2003-09-22

Publications (2)

Publication Number Publication Date
WO2005027636A2 true WO2005027636A2 (fr) 2005-03-31
WO2005027636A3 WO2005027636A3 (fr) 2005-06-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/004037 WO2005027636A2 (fr) 2003-09-22 2004-09-22 Traitement topique ameliore pour l'eradication et/ou la lutte contre des ectoparasites

Country Status (1)

Country Link
WO (1) WO2005027636A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008038108A2 (fr) * 2006-09-26 2008-04-03 Giuliani S.P.A. Composition anti-pédiculose agissant par suffocation des poux
FR2949182A1 (fr) * 2009-08-24 2011-02-25 Horizzon Innovations Technologies Utilisation d'une microemulsion pour lutter contre les poux
FR2996453A1 (fr) * 2012-10-08 2014-04-11 Horizzon Innovations Technologies Composition moussante anti-poux
WO2016018164A1 (fr) 2014-07-30 2016-02-04 Icb Pharma Spółka Jawna Composition d'étalement de liquide ayant une activité ectoparasiticide, son procédé et son utilisation pour lutter contre des ectoparasites en médecine humaine et vétérinaire, et dans des environnements agricoles, horticoles et/ou de jardin.
WO2019115980A1 (fr) 2017-12-15 2019-06-20 Laboratoires Arkopharma Composition antiparasitaire à usage externe
FR3075039A1 (fr) * 2017-12-15 2019-06-21 Laboratoires Arkopharma Composition antiparasitaire a usage externe

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2163367A1 (en) * 1971-12-16 1973-07-27 Achard Max Insect bite repellent compsn - contng isopropyl palmitate
DE19742275A1 (de) * 1997-09-25 1999-04-01 Beiersdorf Ag Estern verzweigtkettiger Carbonsäuren und verzweigtkettiger Alkohole als antibakterielle, antimycotische, antiparasitäre oder antivirale Wirkstoffe

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2919280B2 (ja) * 1994-11-02 1999-07-12 武田薬品工業株式会社 木材害虫防除剤
JP2002068917A (ja) * 2000-08-29 2002-03-08 Lion Corp 害虫駆除組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2163367A1 (en) * 1971-12-16 1973-07-27 Achard Max Insect bite repellent compsn - contng isopropyl palmitate
DE19742275A1 (de) * 1997-09-25 1999-04-01 Beiersdorf Ag Estern verzweigtkettiger Carbonsäuren und verzweigtkettiger Alkohole als antibakterielle, antimycotische, antiparasitäre oder antivirale Wirkstoffe

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch, Week 199933 Derwent Publications Ltd., London, GB; Class C03, AN 1996-306415 XP002314967 & JP 02 919280 B2 (TAKEDA CHEM IND LTD) 12 July 1999 (1999-07-12) *
DATABASE WPI Section Ch, Week 200250 Derwent Publications Ltd., London, GB; Class C03, AN 2002-465950 XP002314966 & JP 2002 068917 A (LION CORP) 8 March 2002 (2002-03-08) *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008038108A2 (fr) * 2006-09-26 2008-04-03 Giuliani S.P.A. Composition anti-pédiculose agissant par suffocation des poux
WO2008038108A3 (fr) * 2006-09-26 2009-04-09 Giuliani Spa Composition anti-pédiculose agissant par suffocation des poux
FR2949182A1 (fr) * 2009-08-24 2011-02-25 Horizzon Innovations Technologies Utilisation d'une microemulsion pour lutter contre les poux
WO2011023887A3 (fr) * 2009-08-24 2011-11-17 Horizzon Innovations Technologies Utilisation d'une microemulsion pour lutter contre les poux
FR2996453A1 (fr) * 2012-10-08 2014-04-11 Horizzon Innovations Technologies Composition moussante anti-poux
WO2016018164A1 (fr) 2014-07-30 2016-02-04 Icb Pharma Spółka Jawna Composition d'étalement de liquide ayant une activité ectoparasiticide, son procédé et son utilisation pour lutter contre des ectoparasites en médecine humaine et vétérinaire, et dans des environnements agricoles, horticoles et/ou de jardin.
US11464224B2 (en) 2014-07-30 2022-10-11 Icb Pharma Spolka Jawna Liquid spreading composition with ectoparasiticidal activity, a method and use thereof for combating ectoparasites in human and veterinary medicine, as well as in agricultural, horticultural and/or garden environments
WO2019115980A1 (fr) 2017-12-15 2019-06-20 Laboratoires Arkopharma Composition antiparasitaire à usage externe
FR3075039A1 (fr) * 2017-12-15 2019-06-21 Laboratoires Arkopharma Composition antiparasitaire a usage externe
FR3075040A1 (fr) * 2017-12-15 2019-06-21 Laboratoires Arkopharma Composition antiparasitaire a usage externe

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Publication number Publication date
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