WO2016063963A1 - Inhibiteur pour l'éclosion d'œufs de parasites hématophages, composition pesticide contre des parasites hématophages, et procédé pesticide contre des parasites hématophages - Google Patents

Inhibiteur pour l'éclosion d'œufs de parasites hématophages, composition pesticide contre des parasites hématophages, et procédé pesticide contre des parasites hématophages Download PDF

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Publication number
WO2016063963A1
WO2016063963A1 PCT/JP2015/079883 JP2015079883W WO2016063963A1 WO 2016063963 A1 WO2016063963 A1 WO 2016063963A1 JP 2015079883 W JP2015079883 W JP 2015079883W WO 2016063963 A1 WO2016063963 A1 WO 2016063963A1
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Prior art keywords
blood
sucking
hatching
fatty acid
eggs
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PCT/JP2015/079883
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English (en)
Japanese (ja)
Inventor
彬 日塔
吉田　真也
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アース製薬株式会社
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Priority to JP2016555396A priority Critical patent/JP6756618B2/ja
Publication of WO2016063963A1 publication Critical patent/WO2016063963A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Definitions

  • the present invention relates to a hatching inhibitor of blood-sucking pest eggs, an insecticidal composition of blood-sucking pests, and a method of killing blood-sucking pests.
  • head lice and head lice such as head lice and body lice are known as lice parasitic on humans.
  • head lice infection has been increasing in recent years, and children, children, etc. are severely damaged by group life, and infection to their families has also been reported.
  • egg eradication is also important. If lice eggs remain in the hair or if flea eggs remain in the pet's body hair, for example, the lice eggs may fall on the bedding together with the hair, or from the pet's body hair. When flea eggs fall and become adults, further infection may spread from there. In addition, even if adults are exterminated by the use of insecticides and symptoms are temporarily relieved, they will be damaged again by newly hatched lice and fleas. In such a case, the discontinuation and resumption of the insecticide are repeated, which causes an increase in drug-resistant insects.
  • Japanese Unexamined Patent Publication No. 6-298628 Japanese Unexamined Patent Publication No. 10-81616 Japanese Laid-Open Patent Publication No. 54-5027
  • the means (1) for example, when a medicine is used for shampoo, there is a concern about its safety because it directly contacts the human body.
  • the means (2) can be expected to have an ovicidal effect, silicone oil hardly dissolves in a hydrophilic solvent, so that it is difficult to handle and difficult to use on the entire hair and scalp.
  • it is difficult to remove all eggs by the means (3).
  • the means (3) in controlling a blood-sucking pest, it is important to control not only the adult but also the egg.
  • there are few compounds having both an insecticidal action and an egg-killing action as an active ingredient Usually, the activity on eggs cannot be inferred from the activity on larvae and adults, and the activity of compounds on eggs is lower than that on adults. This is because the egg shell has durability, and the compound is unlikely to act inside the egg.
  • an object of the present invention is to provide a means that does not contain an insecticide such as a pyrethroid and is easy to handle and can control eggs of blood-sucking pests such as lice and fleas.
  • the present inventors have found that the egg hatching inhibitory effect of blood-sucking pests, which is very effective for specific fatty acid esters, and the larval or adult eradication effects after egg-sucking insects are hatched As a result, the present invention has been completed.
  • the present invention is achieved by the following (1) to (7).
  • An inhibitor of hatching of blood-sucking pest eggs comprising a fatty acid ester having a larger number of carbon groups.
  • a blood-sucking pest insecticidal composition comprising the blood-sucking pest egg hatching inhibitor according to any one of (1) to (3) above.
  • the hatching inhibitor of blood-sucking pest eggs inhibits blood-sucking pests such as lice and fleas from hatching from eggs, and therefore can effectively control (killing) lice and flea eggs.
  • the hatching inhibitor of the present invention is contained in the insecticidal composition as an active ingredient, so that it can control not only eggs of blood-sucking pests but also their larvae and adults. Is also effective.
  • the hatching inhibitor of blood-sucking pest eggs of the present invention does not contain an insecticidal component such as a pyrethroid, it is safe for the human body, so the insecticidal composition is used as an active ingredient in hair preparations such as shampoos and rinses. When contained and used, it is safe and easy to control blood-sucking pest eggs, their larvae and adults.
  • the hatching inhibitor of blood-sucking pest eggs the insecticidal composition of blood-sucking pests, and the method of killing blood-sucking pests according to the present invention will be described in more detail.
  • insecticide includes not only insect pest larvae and adults but also extermination (eggicide) of their eggs
  • insecticide composition means “insecticide egg composition”.
  • Insecticidal method means “insecticidal egg-killing method”.
  • Examples of the blood-sucking pests to be treated in the present invention include pests that suck blood for living such as lice, fleas, and ticks.
  • Examples of the lice include human blood-sucking lice such as head lice, white lice, body lice, and bed bugs, as well as louses that parasitize thermostats such as dog lice such as dog lice, domestic animals such as dog lice, pets, and pets.
  • Examples of fleas include cat fleas, dog fleas, and human fleas.
  • the hatching inhibitor of blood-sucking pest eggs of the present invention is preferably intended for at least one of lice and fleas.
  • the hatching inhibitor of blood-sucking pest eggs of the present invention is a fatty acid ester containing a fatty acid residue and an alcohol residue, and both the fatty acid residue and the alcohol residue have a branched structure, and It is characterized by comprising a fatty acid ester (hereinafter sometimes referred to as “the specific fatty acid ester of the present invention”) in which the alcohol residue has a larger number of carbon atoms than the fatty acid residue.
  • the carbon number of the alcohol residue in the specific fatty acid ester may be larger than the carbon number of the fatty acid residue, and specifically, the carbon number of the alcohol residue with respect to the carbon number of the fatty acid residue in the specific fatty acid ester. Is preferably 1.1 or more. Further, it is more preferable that the alcohol residue has about 1 to 10 more carbon atoms than the fatty acid residue.
  • the number of carbon atoms of the fatty acid residue in the specific fatty acid ester is preferably 7 to 13, and more preferably 8 to 9.
  • the second carbon atom from the terminal is preferably a secondary carbon atom or a tertiary carbon atom in each of the fatty acid residue and the alcohol residue.
  • Specific fatty acid esters of the present invention specifically include isodecyl isononanoate, isotridecyl isononanoate, 2-hexyldecyl 2-ethylhexanoate and the like. It may be used. Among them, isotridecyl isononanoate and 2-hexyldecyl 2-ethylhexanoate are preferable because they have a very high ovicidal effect on lice and flea eggs. Furthermore, isotridecyl isononanoate is particularly preferable because it is difficult to solidify even at low temperatures and has excellent storage stability for a long period of time.
  • the specific fatty acid ester of the present invention can inhibit the hatching of blood-sucking pests. Since it is a long chain, it has high permeability to eggshell, and since both fatty acid residues and alcohol residues have a branched structure, it has permeability that is not found in linear fatty acid esters. Therefore, it is presumed that it is effective immediately against eggs of blood-sucking pests and their larvae or adults.
  • straight-chain fatty acid esters and short-chain fatty acids have low affinity and penetrability to the egg surface and are easily washed off the egg surface with water, etc., so rinse with detergent or water used for the human body. In the method of use, there is no control effect on eggs.
  • the specific fatty acid ester of the present invention is a liquid having a low viscosity at room temperature and can be easily treated on the entire hair and body hair.
  • a preservative such as a bactericidal agent or a surfactant for stabilizing the formulation.
  • a preparation with reduced irritation caused by the above can be obtained.
  • the specific fatty acid ester of the present invention has a very high affinity for eggshell, and is presumed to have a very strong and effective hatching-inhibiting effect on blood-sucking pest eggs.
  • the exterminating effect with respect to the larva after the egg hatching of the blood-sucking pest or its adult is good.
  • the insecticidal composition for blood-sucking pests according to the present invention is characterized by containing the blood-sucking insect egg hatching inhibitor of the present invention as an active ingredient.
  • the insecticidal composition for blood-sucking pests according to the present invention can exert an extermination effect against blood-sucking pest eggs or larvae or adults after hatching of blood-sucking pests.
  • the content ratio of the hatching inhibitor of the blood-sucking pest egg of the present invention in the insecticidal composition of the blood-sucking pest of the present invention may be appropriately determined depending on the object (for example, hair, body hair, etc.) to which the composition is applied. For example, about 20 to 500 mg, preferably about 50 to 250 mg may be brought into contact with the hair-absorbing insect egg hatching inhibitor of the present invention per hair bundle (length 10 cm, equivalent to 550 to 600 hairs). .
  • an amount of the active ingredient sufficient for the blood-sucking pest egg attached to the hair bundle can be sufficiently brought into contact with the eggs of blood-sucking pests.
  • the contact time for bringing the blood-sucking pest egg hatching inhibitor of the present invention into contact with an object is, for example, preferably 1 minute or longer, more preferably 5 minutes or longer, and even more preferably 10 minutes or longer.
  • a sufficient extermination effect can be obtained for the larvae or adults of the blood-sucking pest.
  • a very high extermination effect can be obtained even for blood-sucking pest eggs by contact for 5 minutes or more.
  • the hatching inhibitor of the blood-sucking pest egg of the present invention adheres to the object by bringing the hatching inhibitor of the blood-sucking pest egg of the present invention into contact with the egg of the blood-sucking pest or its larvae or adults for the above-mentioned time. It can sufficiently act on the blood-sucking pest eggs, or its larvae or adults, and exert a sufficient extermination effect.
  • the insecticidal composition for blood-sucking pests of the present invention can contain silicone oil. Since the hatching inhibitor of blood-sucking pest eggs according to the present invention has good compatibility with silicone oil, the effects of the hatching inhibitor of blood-sucking pest eggs according to the present invention by mixing these, It is possible to provide an insecticidal composition for blood-sucking pests, which has both the effect of suffocating the adult insects and eggs of silicone oil.
  • silicone oils include chain silicones such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane, methylhydrogenpolysiloxane, trisiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane.
  • chain silicones such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane, methylhydrogenpolysiloxane, trisiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane.
  • cyclic silicones such as dimethiconol, and modified silicones such as dimethiconol. These may be used alone or in combination of two or more. Among these, from the viewpoint of the effects of the present
  • a cyclic silicone particularly decamethylcyclopentasiloxane, should be used in that case. Therefore, it is preferable because a stimulus suppressing effect on the human body can be obtained.
  • the ratio of the blood-sucking pest egg hatching inhibitor to the silicone oil of the present invention is 1 to 10 parts by weight of silicone oil per 100 parts by weight of the blood-sucking pest egg hatching inhibitor.
  • the amount is preferably 90 parts by weight, and more preferably 4 to 80 parts by weight.
  • the silicone oil is 4 parts by weight or more with respect to 100 parts by weight of the hatching inhibitor of blood-sucking pest eggs, the insecticidal effect of the blood-sucking pests on the adults can be sufficiently obtained by the silicone oil. If it exists, it is preferable from the surface of stimulus suppression.
  • the insecticide composition of blood-sucking pests of the present invention is used as a solvent by using silicone oil itself as a solvent. And a silicone oil-only preparation.
  • the blood-sucking pest insecticidal composition of the present invention can contain various components that are pharmacologically acceptable to the human body as other components.
  • examples of other components include solvents, thickeners (thickening agents), surfactants, and fragrances.
  • the solvent is blended in order to dissolve each component in the insecticidal composition of the blood-sucking pest of the present invention.
  • the solvent include water, water-soluble solvents (such as glycerin), alcohol solvents (such as methanol and ethanol), and hydrocarbon solvents (such as liquid paraffin).
  • the thickener imparts an appropriate viscosity to the blood-sucking pest insecticidal composition of the present invention, prevents dripping, and the lice insecticidal composition is applied to the face and clothing during the treatment and within the treatment time. Prevents liquid from dripping and adhering.
  • thickeners include oil-based thickeners such as silicic anhydride, dextrin palmitate, (behenic acid / eicosanedioic acid) glyceryl, and poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer.
  • Aqueous thickeners such as a thickener, carboxyvinyl polymer, and dextrin are mentioned.
  • Surfactant is blended in order to enhance detergency in washing away after the treatment with the insecticidal composition of the blood-sucking pest of the present invention.
  • the surfactant By using the surfactant, it becomes easy to wash out the insecticidal composition of the blood-sucking pest, and it is also possible to impart a thickening (viscous) effect to the insecticidal composition of the blood-sucking pest.
  • the surfactant include polysorbate, polyoxyethylene tetraoleate (POE) sorbit, and polyethylene glycol diisostearate (PEG).
  • the fragrance is blended for the purpose of imparting a scent to the insecticidal composition of the blood-sucking pest of the present invention and imparting a scent for enhancing the feeling during use.
  • blending a fragrance it is possible to enhance the feeling of use effect.
  • the insecticidal composition for blood-sucking pests of the present invention is usually used by directly treating the scalp or skin of humans or animals. For example, after wetting human or animal hair, body hair, etc. with water, the insecticidal composition of the blood-sucking pest is diluted as it is or with 2 to 50 times the amount of water, and the hair, body hair, etc. It can be applied according to the application method of a hair treatment agent (hair preparation) such as a normal shampoo, for example, by treating the skin and washing off with water as necessary.
  • a hair treatment agent hair preparation
  • a normal shampoo for example, by treating the skin and washing off with water as necessary.
  • the hatching of the blood-sucking pest eggs of the present invention per hair bundle (length 10 cm, equivalent to 550 to 600 hairs) as a hatching inhibitor of the blood-sucking pest eggs of the present invention
  • As an inhibitor for example, 20 to 500 mg, preferably about 50 to 250 mg may be contacted.
  • As an active ingredient it is effective to use it as a hatching inhibitor of blood-sucking pest eggs of the present invention at about 20 to 500 mg with respect to the hair bundle.
  • the blood-sucking pest insecticidal composition of the present invention is preferably in the form of, for example, a hair treatment agent (hair preparation) such as a shampoo composition or a rinse agent in order to maximize its effects.
  • a hair treatment agent such as a shampoo composition or a rinse agent
  • the hatching inhibitor of the blood-sucking pest egg of this invention, water, surfactant, various additives, and a silicone oil can be further contained as a suitable form.
  • the ratio of the blood-sucking pest egg hatching inhibitor of the present invention in the hair preparation is preferably, for example, 4 to 80% by weight based on the whole hair preparation.
  • the dosage is effective for controlling the blood-sucking pest eggs and the larvae or adults of the blood-sucking pests. can do.
  • the ratio of the silicone oil in the hair preparation may be in accordance with the ratio of the hatching inhibitor of the blood-sucking pest eggs of the present invention and the silicone oil, but for example, it is preferably about 4 to 80% by weight with respect to the whole hair preparation.
  • the surfactant examples include an anionic surfactant and an amphoteric surfactant.
  • the anionic surfactant include fatty acid soaps such as sodium stearate and triethanolamine palmitate, alkyl ether carboxylic acids and salts thereof, carboxylates such as condensation of amino acids and fatty acids, alkyl sulfonic acids, and alkene sulfonates.
  • amphoteric surfactants examples include betaines, aminocarboxylates, imidazoline derivatives, and the like.
  • the amount of the surfactant used is, for example, 1 to 50% by weight, more preferably 1 to 10% by weight, based on the whole hair preparation.
  • additives examples include preservatives, fragrances, dyes, buffers, pH adjusters, antioxidants, viscosity adjusters, cell stabilizers, chelating agents, conditioning agents, and the like, and these are known ingredients. May be used as appropriate.
  • the pH of the hair preparation is, for example, 4 to 8, preferably 5 to 8.
  • the composition has high stability, and there is no irritation to the human body and the feeling of use is good. Furthermore, it does not impair the activity of the hatching inhibitor of blood-sucking pest eggs of the present invention.
  • Test Example 1 As a lice egg, an egg of a white leaf lice (Pediculus humanus corporis) was used. Specifically, on the day before the experiment, about 100 heads of body lice immediately after blood sucking were released on a hair bundle (length: 10 cm, about 550 to 600 hairs) under conditions of 30 ° C. and 50% relative humidity (RH). Eggs were laid for 1 day. Thereafter, only adults were collected from the hair bundle, and hair with lice eggs to be used in the experiment was obtained. In addition, about 10 lice eggs were attached to the hair bundle. 2.5 mL of various specimens shown in Table 1 below were placed in a petri dish ( ⁇ 90 mm), the hair bundle was immersed, and left for 5 minutes.
  • Table 1 2.5 mL of various specimens shown in Table 1 below were placed in a petri dish ( ⁇ 90 mm), the hair bundle was immersed, and left for 5 minutes.
  • the hair bundle was transferred to a mesh (aperture 177 ⁇ m), washed with running water to remove moisture, and then transferred to a petri dish ( ⁇ 90 mm) with clean filter paper. It was allowed to stand at room temperature (30 ° C.) for 10 days, and visually observed after 10 days to examine the hatching inhibition rate. It calculated
  • Test Example 3 Prepare each composition (Examples 1 to 9, Comparative Examples 1 to 3) according to the prescription shown in Table 3 below using Samples 1 to 3, 5, and 9 confirmed to be compatible with dimethicone in Test Example 2 did.
  • a louse egg was used as a lice egg. Specifically, on the day before the experiment, about 100 adult white leaf worms immediately after blood sucking were released on the hair bundle and allowed to lay eggs for 1 day under the conditions of 30 ° C. and RH 50%. Thereafter, only adults were collected from the hair bundle, and hair with lice eggs to be used in the experiment was obtained. In addition, about 10 lice eggs were attached to the hair bundle.
  • Hatching rate (%) number of test specimens hatched / control hatching rate
  • Hatching inhibition rate (%) (1 ⁇ test specimen hatching rate / control hatching rate) ⁇ 100 The test is performed a plurality of times (3 to 12 times) for each composition, and the hatching inhibition rate is the average value. The results are shown in Table 4.
  • Test Example 4 The insecticidal efficacy against adult lice was evaluated using specimens 1 to 3 that were confirmed to have a strong hatching inhibitory effect on lice eggs in Test Example 1.
  • Each composition (Examples 10 to 16 and Comparative Examples 4 to 7) was prepared according to the formulation shown in Table 5 below.
  • Lethality rate (%) number of lethality by test sample / number of test insects x 100 The test is repeated twice for each specimen, and lethality is the average value. The results are shown in Table 5.
  • ⁇ Skin irritation test> The left and right backs of white guinea pigs (Hartley (purchased from Nippon SLC Co., Ltd., male 28-30 weeks old) were removed with an electric clipper to expose the skin. Each composition was impregnated with a fixed amount (50 ⁇ L / cm 2 ) in a lint cloth (produced by Pip Tokyo Co., Ltd.) of 1.2 ⁇ 1.2 cm, and a hermetic surgical tape Blender (Sumitomo 3M) having a size of 5 ⁇ 6 cm. Backing, making a patch, affixing it to the skin surface (approx.
  • an elastic adhesive tape (Elatex 3 2.5 cm x 5 m, Alcare) around the body of a white guinea pig And occluded for 24 hours. After 24 hours, the patch was removed, and the skin reaction after 24 hours was observed to evaluate skin irritation.
  • the skin reaction was evaluated as “strongly irritating when skin reaction with large blisters or strong erythema appears: XX”, and when skin reaction with blisters with obvious erythema appears as “irritating” : X ”, slight erythema was observed but there was no problem in actual use“ Slightly irritating: ⁇ ”, faint erythema (slight redness was observed) on actual use No problem was evaluated as “almost no irritation: ⁇ ”, and no change in appearance as “no irritation: ⁇ ”. The results are shown in Table 5. In Table 5, “ND” indicates that the skin irritation test has not been performed.
  • the specific fatty acid esters of the present invention isodecyl isononanoate, isotridecyl isononanoate and 2-hexyldecyl 2-ethylhexanoate (Examples 10 to 12), have a lethality after 24 hours against adult lice. It was 80% or more, and it was confirmed that it has a strong control effect against adult lice. Also in Examples 13 to 17 containing isotridecyl isononanoate as an active ingredient, the lethality after 24 hours was 100%, and all leaf lice were able to be lethal.
  • the specific fatty acid ester of the present invention can suppress irritation to the skin while securing a lethality after 24 hours by using in combination with a solvent such as liquid isoparaffin and silicone oil such as decamethylcyclopentasiloxane. I understood.
  • the washed cat flea eggs were stored for 3 days under conditions of 25 ° C. and 75% RH, and the number of hatching thereafter was counted. The test was performed 5 times. The results are shown in Table 6. Further, as a control, only the washing treatment with a shampoo agent was performed without adding isotridecyl isononanoate dropwise. Specifically, 20 to 35 cat flea eggs were placed on a Buchner funnel with filter paper, 250 ⁇ L of a commercially available shampoo agent was added dropwise, and after acclimation, suction filtration was performed while 1 mL of water was added dropwise to wash off the shampoo agent. . Thereafter, the washed cat flea eggs were stored for 3 days under conditions of 25 ° C. and 75% RH, and the number of hatching thereafter was counted. The test was performed 5 times. The results are shown in Table 6.
  • isotridecyl isononanoate which is a specific fatty acid ester of the present invention, has a hatching inhibition rate of 70.7%, and a strong hatching inhibitory effect on cat flea eggs was confirmed.
  • prescription examples (formulation examples 1 to 22) of hair preparations containing the lice egg hatching inhibitor according to the present invention are shown.

Abstract

La présente invention vise à fournir un inhibiteur pour l'éclosion d'œufs de parasites hématophages, une composition pesticide contre des parasites hématophages, et un procédé pesticide et ovicide contre des parasites hématophages, le traitement étant facile, et les imagos de poux et de puces hématophages, ainsi que leurs œufs, pouvant être exterminés sans comporter de pesticide. Cet inhibiteur pour l'éclosion d'œufs de parasites hématophages est un ester d'acide gras qui comprend un résidu d'acide gras et un résidu d'alcool, et dans lequel le résidu d'acide gras et le résidu d'alcool ont une structure ramifiée et le nombre d'atomes de carbone du résidu d'alcool est plus grand que le nombre d'atomes de carbone du résidu d'acide gras.
PCT/JP2015/079883 2014-10-22 2015-10-22 Inhibiteur pour l'éclosion d'œufs de parasites hématophages, composition pesticide contre des parasites hématophages, et procédé pesticide contre des parasites hématophages WO2016063963A1 (fr)

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
JP2019081752A (ja) * 2017-10-30 2019-05-30 アース製薬株式会社 吸血性害虫の定着阻害方法及び吸血性害虫の定着阻害剤
JP2019189533A (ja) * 2018-04-19 2019-10-31 株式会社大阪製薬 シラミの卵駆除剤
GB2574022A (en) * 2018-05-22 2019-11-27 Thornton & Ross Ltd A pediculicidal shampoo

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