WO2004105649A1 - Cartouche d'injection destinee a inserer une lentille intra-oculaire et dispositif d'insertion de lentille intra-oculaire - Google Patents

Cartouche d'injection destinee a inserer une lentille intra-oculaire et dispositif d'insertion de lentille intra-oculaire Download PDF

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Publication number
WO2004105649A1
WO2004105649A1 PCT/JP2004/007913 JP2004007913W WO2004105649A1 WO 2004105649 A1 WO2004105649 A1 WO 2004105649A1 JP 2004007913 W JP2004007913 W JP 2004007913W WO 2004105649 A1 WO2004105649 A1 WO 2004105649A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
intraocular lens
injector
lens
resin
Prior art date
Application number
PCT/JP2004/007913
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English (en)
Japanese (ja)
Inventor
Hidetoshi Iwamoto
Original Assignee
Hoya Healthcare Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoya Healthcare Corporation filed Critical Hoya Healthcare Corporation
Priority to JP2005506592A priority Critical patent/JPWO2004105649A1/ja
Publication of WO2004105649A1 publication Critical patent/WO2004105649A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1662—Instruments for inserting intraocular lenses into the eye
    • A61F2/1664—Instruments for inserting intraocular lenses into the eye for manual insertion during surgery, e.g. forceps-like instruments

Definitions

  • the present invention relates to an intraocular lens introduction injector and a cartridge, and an intraocular lens introduction device. More specifically, the present invention relates to an intraocular lens, an injector cartridge for use in inserting the intraocular lens from a relatively small incision wound, and an intraocular lens insertion device using the injector cartridge. is there.
  • the intraocular lens includes a polymethyl methacrylate lens made of a hard material with a glass transition 3 ⁇ 4S of 10 o ° c or more, and a soft intraocular material made of a silicone-based acrylic material developed as a lens for small incision surgery. The lens has been raised.
  • the surgeon holds the injector body in his hand, pushes the lens installed in the cartridge while pushing the plunger forward, and inserts the lens into the eye.
  • a push type and a screw type as a mechanism for pushing out the plunger.
  • the injector body does not touch the eyeball tissue, but the tip of the cartridge is inserted into the eyeball.
  • a glycerol ester of a carboxylic acid having about 10 to 30 carbon atoms per molecule as a lubricating component for example, a polypropylene resin, a glycerol ester of a carboxylic acid having, for example, glycerol monostearate, monopalmitic acid Glycerol and glycerol monooleate are added and molded.
  • the lubricity improving component is bleeded to the surface, and the inner surface is coated with a hydrophilic component such as hydroxymethylcellulose.
  • a technique for producing the same for example, see Japanese Patent Application Laid-Open No. 2000-51043333).
  • the lens bent small inside the hollow tube can be smoothly slid and moved inside the tube by the lubricity improving component bleeding on the inner surface of the hollow tube, and inserted into the eyeball. it can.
  • the lens can be pushed out from a fairly small hollow tube with a moderate force.
  • a technique is known in which the inner wall of a cartridge is coated with a covalently bonded lubricity improving component, for example, polybutylpyrrolidone or polyethylene render glycol (see, for example, Japanese Patent Application Laid-Open No. 2001-504704). ).
  • a covalently bonded lubricity improving component for example, polybutylpyrrolidone or polyethylene render glycol
  • the intraocular lens has a lubricity improving component bleeding on the inner surface of the cartridge.
  • the lubricity improving component adheres to the surface of the optical part or the loop of the lens, and as a result, the lubricity improving component stays in the eye, which is a very serious problem in terms of safety.
  • the amount of the lubricating component varies depending on the temperature and humidity, it is extremely difficult to control the amount of bleed and maintain quality.
  • JP-T-200-501-433 requires an oxygen plasma treatment step and a blooming step.
  • the technique disclosed in Japanese Patent Publication No. 40 has a problem that the process is complicated, such as irradiating the coating on the inner wall with ultraviolet rays, and the cost is inevitably increased.
  • a cartridge was prepared by adding glycerol monostearate as a lubricity improving component to a polypropylene resin, followed by oxygen plasma treatment and bridging treatment. Although the extruded state was improved, it became clear that the lubricity improving component was attached to the optical part of the intraocular lens (see Comparative Example 4 described later).
  • the present invention is directed to an injector cartridge which is used when an intraocular lens is bent from a relatively small incision and is introduced into the eye under such circumstances, and an excessive force is applied when the lens is inserted.
  • various compounds present as lubricity improving components on the inner surface of the cartridge do not adhere to the lens, making it extremely safe and easy to manufacture.
  • the primary object of the present invention is to provide a lens introduction injector.
  • the present invention also provides an injector for inserting an intraocular lens which achieves the first object.
  • a second object is to provide an intraocular lens insertion device using a cartridge.
  • the inventor of the present invention has conducted intensive studies to develop an intraocular lens having the above-mentioned excellent functions, an injector and a cartridge for insertion and an intraocular lens insertion device. As a result, the lens of a cartridge made of a slidable resin was obtained. If the inner wall surface of the hollow tube from the inlet to the outlet is roughened and the slidable resin that composes the cartridge has a coefficient of friction less than a certain value, the purpose can be achieved. The present inventors have completed the present invention based on these findings.
  • an intraocular lens insertion device used for implanting and implanting a soft intraocular lens from the incision into the eyeball, a lens attached to the injector body having an extrusion mechanism and implanted into the eye
  • a cartridge made of a slidable resin having a hollow structure for installing and housing and extruding the lens into the eye, wherein the inner wall surface of the hollow tube of the cartridge is roughened, and the slide forming the cartridge is provided.
  • the conductive resin is a resin having a friction coefficient of 0.5 or less
  • the slidable resin having a friction coefficient of 0.5 or less is at least one selected from a high-molecular-weight polyethylene resin, a fluorine-based resin, a polyamide-based resin, a polyacetal resin, and a polyphenylene phenol resin.
  • An intraocular lens insertion device including an injector body and the intraocular lens insertion injector cartridge according to any one of claims 1 to 5, and (7) The intraocular lens insertion device according to claim 6, wherein the injector cartridge for introducing the intraocular lens and the injector body are integrated or separable.
  • the intraocular lens introduction injector force cartridge of the present invention can safely insert the lens into the eye with an appropriate force without damaging the supporting portion and the optical portion of the lens. Since there is no need for an improving component, it has an effect of being excellent in safety. By using this injector cartridge, an intraocular lens insertion device useful in ophthalmic surgery can be obtained.
  • FIG. 1 is a partially transparent perspective view of an example of an injector power cartridge according to the present invention.
  • FIG. 2 is a perspective view of an example of an injector main body used to mount the injector cartridge of the present invention.
  • the intraocular lens insertion injector force cartridge of the present invention has an extrusion mechanism in an intraocular lens insertion device used when implanting and implanting a soft intraocular lens into the eyeball from a relatively small incision.
  • This is a cartridge made of a slidable resin having a hollow structure for mounting and storing a lens to be implanted into the eye, mounted on the injector body, and for pushing the lens into the eye.
  • the coefficient of friction measured by the following method is 0.5 or less, preferably 0.4 or less, more preferably Use 0.2 or less resin.
  • the coefficient of friction can be measured in accordance with ASTM D1884.For example, using a thrust type testing machine, select SUS304 as the mating material, place the test piece on it, and at room temperature. Measure.
  • Such resins include high molecular weight polyethylene resins, fluorine resins, polyamide resins, polyacetal resins, and polyphenylene sulfide.
  • high molecular weight polyethylene resin (HMW-PE) is manufactured by Ziegler polymerization technology, and the average molecular weight is 100,000 to 6 It is a polyethylene resin of about 100,000, and has properties such as excellent wear resistance and impact strength, low friction coefficient, excellent self-lubricating properties, and extremely low water absorption.
  • Fluorocarbon resins have excellent properties such as excellent heat resistance, chemical resistance, and electrical insulation as well as unique non-adhesiveness and low friction.
  • fluorine-based resin examples include tetrafluoroethylene resin, tetrafluoroethylene-hexafluoropropylene copolymer resin, tetrafluoroethylene-perfluoroalkoxyethylene copolymer resin, trifluoroethylene chloride resin, and tetrafluoroethylene resin.
  • Some powers such as fluorinated ethylene-ethylene copolymer resin and vinylidene fluoride resin are among these.
  • Polyamide resins have, as common properties, excellent impact resistance, oil resistance, chemical resistance, and heat resistance, as well as a low coefficient of friction, excellent wear resistance, and self-lubricating properties.
  • polyamide system examples include nylon 6, nylon 66, nylon 610, nylon 612, nylon 11, nylon 12, and the like.Nylon 6, nylon 66, nylon 1 2 is preferred.
  • Polyacetal resin has excellent properties such as excellent creep resistance, fatigue resistance, and toughness, excellent friction and wear properties, self-lubricating properties, and the ability to be used as a sliding member without lubrication. are doing .
  • Polyphenylene sulfide resin has excellent heat resistance, flame retardancy, chemical resistance, mechanical properties, and dimensional stability, and has a low friction coefficient. Used as advanced sliding material.
  • one of these slidable resins may be used alone, or two or more thereof may be used in combination.
  • An appropriate amount of the third component can be added.
  • the slidable resin it is desirable that the state in which the lens is installed and stored in the cartridge and the state in which the lens is pushed out can be confirmed from the outside, and therefore, a resin having transparency is preferable.
  • a high molecular weight polyethylene resin is particularly preferable in terms of balance between slidability, transparency, and moldability.
  • the inner wall surface of the hollow tube is roughened. This roughening reduces the contact area between the lens surface and the inner surface of the hollow tube, and also allows a viscous substance, such as hyaluronic acid, used when penetrating the lens into the eye to make the contact between the lens surface and the inner surface of the hollow tube. It is applied so that it is not completely removed from the gap This further improves the slip of the lens.
  • a viscous substance such as hyaluronic acid
  • the roughening is preferably performed so as to form streaks in the longitudinal direction on the inner wall surface of the hollow tube of the cartridge, and is preferably performed on the entire inner wall surface of the hollow tube from the intraocular lens to the entrance to the exit. .
  • the average surface roughness Ra of the inner wall surface of the roughened hollow tube is usually about 0.5 to 5.5 ⁇ in order to push the lens into the eye smoothly with a small force. If this Ra is less than 0.5 ⁇ , a large force may be required to push out the lens, and it is difficult to achieve the object of the present invention. On the other hand, if it exceeds 5.0 O / m, the resistance becomes large. It is not preferable.
  • the preferred value of Ra is 0.7 to 3.3.
  • the average surface roughness R a is Taylor Hobson Ne ring form Talysurf (scanning distance:. 0 5 mm s approximate shape: Conca V e, stylus: diamond) is a value measured using a.
  • the method for roughening the inner wall surface of the cartridge hollow tube is not particularly limited as long as the inner wall surface can be easily roughened.
  • the following method can be employed. Specifically, a method is used in which a cartridge is formed using a mold for forming a hollow tube having a roughened surface of a mold pin portion for forming a hollow tube.
  • sandpaper surface polishing, sandplasting and chemical etching, such as sipo processing should be used with warworms or in combination.
  • the surface shape of the mold pin portion is transferred to the inner wall surface of the cartridge hollow tube, it is preferable that the surface of the mold pin portion is roughened in the longitudinal direction into a stripe shape.
  • a method of roughening the inner wall surface of the hollow tube of a cartridge formed by using a normal mold with a cylindrical file or sandplast having the same inner diameter, or a method of performing plasma processing can be used.
  • roughing is performed using a cylindrical file, it is preferable to extrude the file in the longitudinal direction of the cartridge.
  • the ophthalmic lens insertion device of the present invention includes an injector main body and an intraocular lens inserting injector.
  • the injector main body constituting the intraocular lens insertion device may be a known injector body.
  • Examples of the material include metal, ceramics, and plastics.
  • the above-described injector cartridge of the present invention is used as an injector cartridge for inserting an intraocular lens adapted to the injector body.
  • the injector body and the injector cartridge may be integrated or may be separable.
  • the injector main body and the injector cartridge are integrated, it is preferable to use the same material as the injector main body (slidable resin) as the material of the injector main body.
  • the cartridge is separable, the above various materials can be used as the material of the injector body.
  • FIG. 1 is a partially transparent perspective view of an example of an injector force cartridge according to the present invention.
  • a cartridge 10 includes a hollow tube 1 having a distal end portion 2 inserted into an eye, and a cartridge. And a plate-shaped body 3 and 3 'for holding by hand when attached to the main body.
  • FIG. 1 shows a state in which the soft intraocular lens 4 is installed and housed in a cartridge (not shown) filled with a viscoelastic substance such as hyanoleronic acid. At least the tapered portion 6 of the cartridge 10 to the outlet of the distal end portion 2 is roughened in a longitudinal direction in a stripe shape.
  • FIG. 2 is a perspective view of an example of the injector main body.
  • the injector main body 20 includes a hand member 11 having a cartridge mounting portion 13 and a plunger 12. After the cartridge 10 in which the lens 4 is installed and stored is mounted on the cartridge mounting portion 13 of the hand member 11, the plunger 12 is pressed, whereby the lens 4 is moved into the hollow space 5 in the cartridge. Through the cartridge, it is extruded into the eye from the tip 2 of the cartridge together with a viscoelastic substance such as hyal valerate. Since the injector cartridge of the present invention is made of a slidable resin and the inner wall surface of the hollow tube is roughened, no excessive force is required when inserting the lens into the eye.
  • lubricity-improving components on the inner surface do not adhere to the lens, and are extremely safe.
  • a lubricity improving component is mixed with resin.
  • oxygen plasma treatment it is necessary to perform a complicated operation such as oxygen plasma treatment, and to coat the inner surface of the hollow tube of the cartridge with a lubricity-improving component, it is difficult to apply ultraviolet light.
  • the present invention can extremely easily produce a desired cartridge only by roughening the mold pin portion with sandpaper or the like.
  • the coefficient of friction of the resin in the following Examples and Comparative Examples was as follows: SUS304 was selected as the mating material in accordance with ASTMD1894, and a test piece was placed on top of it, at a temperature of 23 ⁇ 2 ° C and a humidity of 50 ⁇ 10%. Measured in RH.
  • the surface of the die pin portion forming the hollow tube of the cartridge was polished with a paper file (# 120) in the longitudinal direction of the die pin portion, and the surface was subjected to a line-shaped roughening process.
  • the outer diameter of this pin is 2.1 mm.
  • This cartridge is filled with hyaluronic acid as a viscoelastic substance, a soft intraocular lens [HOY A Healthcare Co., Ltd., trade name "Acrifold (20D) J”] is folded and set.
  • a soft intraocular lens [HOY A Healthcare Co., Ltd., trade name "Acrifold (20D) J”] is folded and set.
  • the plunger was pushed in using an universal testing machine manufactured by Instron Japan Co., Ltd., and the maximum load required at that time was recorded. The presence or absence of the deposits was observed and confirmed with a stereoscopic microscope (X60). The results are shown in Table 1.
  • Example 1 Using the cartridge prepared in Example 1, an extrusion test of a 30D soft 1 "raw ocular lens [HOY A Healthcare Co., Ltd., trade name” Acrifold (30D) "] was carried out in Example 1. Was carried out similarly to The results are shown in Table 1.
  • Example 4 Using this cartridge, an extrusion test of a soft 14 intraocular lens acrylic foam (20D) (described above) was performed in the same manner as in Example 1. The results are shown in Table 1. The maximum load was as low as 3.43 mm, and there was no lens damage or attachment to the lens.
  • Example 4
  • a cartridge was formed by molding a fluororesin [trade name “AFLON COP88AXP”, manufactured by Asahi Glass Co., Ltd., with a coefficient of friction of about 0.1]. Thereafter, the cartridge was washed with water and dried. The average surface roughness Ra of the inner wall surface of the hollow tube of this cartridge was 1.5 / in.
  • nylon 66 resin manufactured by Toray Industries, Inc., trade name “CM3001NJ, coefficient of friction about 0.2”
  • the cartridge was washed and dried, and the average surface roughness Ra of the inner wall surface of the hollow tube of this cartridge was 2. ⁇ .
  • Example 1 was carried out in the same manner as in Example 1, except that the mold for resin molding had a mirror-finished pin portion surface. The results are shown in Table 2. The maximum load was extremely high, 14.7 N, and the lens support was damaged.
  • the average surface roughness Ra of the inner wall surface of the hollow tube of the cartridge was 0.1 ⁇ Comparative Example 2
  • a cartridge was formed by molding a polypropylene resin [manufactured by San-Alomer Co., Ltd., trade name “San-Alomer ⁇ 921 ⁇ ”, coefficient of friction about 0.6]. Thereafter, the cartridge was washed with water and dried.
  • the product was molded into a cartridge by molding “Salomar ⁇ 921 Yj, coefficient of friction about 0.6”. Thereafter, the cartridge was washed with water and dried. The surface roughness Ra was 1.5 ⁇ .
  • Example 2 An extrusion test of a soft intraocular lens acrylic (20 D) (described above) was carried out in the same manner as in Example 1. The results are shown in Table 2. The maximum load was extremely high, 24.5 mm, and the lens support was damaged. Comparative Example 4
  • Polypropylene resin pellets [Sanaroma Co., Ltd., trade name "Sanaroma PM 9 2 1 Y] and the glycerol monostearate is a lubricant to 0. 2 5 mass 0/0 by forming a pressurized forte cartridge. Then, oxygen plasma treatment ( (40 cm 3 , 13 Pa for 90 minutes), followed by a bridging treatment at 50 for 2 days.
  • Comparative Example 4 the same procedure was performed as in Comparative Example 4, except that the bleeding treatment was changed to 50 ° C. for 4 days. The results are shown in Table 2.
  • Comparative Example 4 was carried out in the same manner as in Comparative Example 4, except that glycerol monostearate was added in an amount of 0.1% by mass and bleeding was performed at 50 ° C for 10 days. The results are shown in Table 2.
  • the intraocular lens insertion injector force cartridge of the present invention can safely insert the lens into the eye with an appropriate force without damaging the supporting portion and the optical portion of the lens, and improves lubricity. It has the effect of being excellent in safety because it does not require any components. By using this injector cartridge, it is possible to obtain an intraocular lens insertion device useful in ophthalmic surgery.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un dispositif d'insertion de lentille intra-oculaire utilisé lorsqu'une lentille intra-oculaire molle est insérée à partir d'une incision ménagée dans un globe oculaire et implantée dans celui-ci. Ce dispositif comprend une cartouche de résine glissante pour l'insertion d'une lentille intra-oculaire installée dans un corps d'injection pourvu d'un mécanisme d'extrusion. En outre, il permet une mise en place durable de la lentille à transplanter dans le globe oculaire, et est formé dans une structure creuse destinée à l'extrusion de la lentille dans le globe oculaire. La surface de paroi intérieure du tube creux de la cartouche est traitée grossièrement, la résine glissante formant la cartouche présentant un coefficient de frottement inférieur ou égal à 0,4.
PCT/JP2004/007913 2003-06-02 2004-06-01 Cartouche d'injection destinee a inserer une lentille intra-oculaire et dispositif d'insertion de lentille intra-oculaire WO2004105649A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2005506592A JPWO2004105649A1 (ja) 2003-06-02 2004-06-01 眼内レンズ挿入用インジェクターカートリッジおよび眼内レンズ挿入装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003156260 2003-06-02
JP2003-156260 2003-06-02

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WO2004105649A1 true WO2004105649A1 (fr) 2004-12-09

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007080869A1 (fr) 2006-01-13 2007-07-19 Hoya Corporation Instrument permettant d'introduire une lentille intraoculaire
WO2008087226A1 (fr) 2007-01-17 2008-07-24 Ajl, S.A. Récipient pour lentille intra-oculaire et procédé d'application d'une lentille intra-oculaire
US7879090B2 (en) 2006-12-13 2011-02-01 Bausch & Lomb Incorporated Intraocular lens injector apparatus and methods of use
US7901414B2 (en) 2001-12-12 2011-03-08 Ioltechnologie-Production Cassette and injector for flexible intraocular lens and method for injecting such lenses
JP2011182998A (ja) * 2010-03-09 2011-09-22 Nidek Co Ltd 眼内レンズ挿入器具
US8273122B2 (en) 2008-06-23 2012-09-25 Abbott Medical Optics Inc. Pre-loaded IOL insertion system
JP2013013457A (ja) * 2011-06-30 2013-01-24 Nidek Co Ltd 眼内レンズ挿入器具
US9549813B2 (en) 2010-08-24 2017-01-24 Abbott Medical Optics Inc. Inserter cap and related features
CN113194876A (zh) * 2018-12-19 2021-07-30 爱尔康公司 凸轮致动的基部折叠机构
US11617643B2 (en) 2007-05-30 2023-04-04 Hoya Corporation Intraocular lens insertion device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002542884A (ja) * 1999-04-30 2002-12-17 アラーガン・セイルズ・インコーポレイテッド 眼内レンズ挿入装置およびその使用方法
JP2003515387A (ja) * 1999-11-30 2003-05-07 フアーマシア・アー・ベー 眼内レンズ移植器

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425734A (en) * 1993-07-02 1995-06-20 Iovision, Inc. Intraocular lens injector
NZ329985A (en) * 1994-11-18 1999-10-28 Vladimir Feingold Preloading an intraocular lens into an intraocular lens injecting system and packaging the system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002542884A (ja) * 1999-04-30 2002-12-17 アラーガン・セイルズ・インコーポレイテッド 眼内レンズ挿入装置およびその使用方法
JP2003515387A (ja) * 1999-11-30 2003-05-07 フアーマシア・アー・ベー 眼内レンズ移植器

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7901414B2 (en) 2001-12-12 2011-03-08 Ioltechnologie-Production Cassette and injector for flexible intraocular lens and method for injecting such lenses
WO2007080869A1 (fr) 2006-01-13 2007-07-19 Hoya Corporation Instrument permettant d'introduire une lentille intraoculaire
JPWO2007080869A1 (ja) * 2006-01-13 2009-06-11 Hoya株式会社 眼内レンズ挿入用器具
US7879090B2 (en) 2006-12-13 2011-02-01 Bausch & Lomb Incorporated Intraocular lens injector apparatus and methods of use
US8252053B2 (en) 2006-12-13 2012-08-28 Bausch & Lomb Incorporated Intraocular lens injector apparatus and methods of use
WO2008087226A1 (fr) 2007-01-17 2008-07-24 Ajl, S.A. Récipient pour lentille intra-oculaire et procédé d'application d'une lentille intra-oculaire
US11938019B2 (en) 2007-05-30 2024-03-26 Hoya Corporation Intraocular lens insertion device
US11617643B2 (en) 2007-05-30 2023-04-04 Hoya Corporation Intraocular lens insertion device
US8273122B2 (en) 2008-06-23 2012-09-25 Abbott Medical Optics Inc. Pre-loaded IOL insertion system
US8685088B2 (en) 2008-06-23 2014-04-01 Abbott Medical Optics Inc. Pre-loaded IOL insertion system
US8968398B2 (en) 2008-06-23 2015-03-03 Abbott Medical Optics Inc. Pre-loaded IOL insertion system
JP2011182998A (ja) * 2010-03-09 2011-09-22 Nidek Co Ltd 眼内レンズ挿入器具
US9687340B2 (en) 2010-08-24 2017-06-27 Abbott Medical Optics Inc. Protective cap for an insertion device and other insertion device features
US9549813B2 (en) 2010-08-24 2017-01-24 Abbott Medical Optics Inc. Inserter cap and related features
JP2013013457A (ja) * 2011-06-30 2013-01-24 Nidek Co Ltd 眼内レンズ挿入器具
CN113194876A (zh) * 2018-12-19 2021-07-30 爱尔康公司 凸轮致动的基部折叠机构

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