WO2004037329A1 - シリンジ、キャップおよびプレフィルドシリンジの製造方法 - Google Patents
シリンジ、キャップおよびプレフィルドシリンジの製造方法 Download PDFInfo
- Publication number
- WO2004037329A1 WO2004037329A1 PCT/JP2003/013540 JP0313540W WO2004037329A1 WO 2004037329 A1 WO2004037329 A1 WO 2004037329A1 JP 0313540 W JP0313540 W JP 0313540W WO 2004037329 A1 WO2004037329 A1 WO 2004037329A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mouth
- syringe
- lock adapter
- distal end
- female connector
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3104—Caps for syringes without needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/1011—Locking means for securing connection; Additional tamper safeties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/20—Closure caps or plugs for connectors or open ends of tubes
Definitions
- the present invention relates to a syringe, a cap, and a prefilled light provided with the cap.
- the present invention relates to a method for manufacturing a syringe.
- various types of medical devices such as syringes, injection needles, catheters, and infusion sets are sometimes used by connecting them.
- a female connector provided at an end of one medical device is fitted into a cavity of a female connector provided at an end of the other medical device.
- some female connectors have a thread groove (female-side threaded portion) formed on the outer peripheral surface.
- the female connector also has an outer peripheral portion of the female connector.
- connection member having a screw thread (male side threaded portion) to be screwed into a thread groove of a female connector.
- connection member having a screw thread (male side threaded portion) to be screwed into a thread groove of a female connector.
- the connecting member is fixed and cannot move relatively along the axial direction of the male connector (actually, No. 2-193). (See Fig. 1 of the Official Gazette) or the extent that the connecting member can be moved slightly along the axial direction of the male connector (see Fig. 2 of the Japanese Utility Model Publication No. 2-193). .
- the connecting member may hinder the connection, and these connections may not be reliably made.
- a predetermined operation that is, an operation of relatively rotating the connecting member (lock nut portion 3) by a predetermined angle around the male taper portion (male luer portion 5) is performed, thereby connecting the connecting member in the axial direction of the male connector. Can be relatively moved along. Then, by moving the connecting member in a direction away from the female taper portion, the entire female portion can be exposed.
- the code used here is the code described in Japanese Patent Application Laid-Open No. Hei 7-148287.
- the connecting member since the connecting member is not fixed in a state where the female part is exposed, when performing the operation of connecting the female connector having no thread groove on the outer peripheral surface to the female taper part, the connecting member is not connected to the female connector. It may move along the axial direction, again obstructing this operation.
- syringes which are frequently used, are required to be able to reliably connect to various medical instruments.
- pre-filled liquid preparations are aseptically filled in sterilized mi (containers).
- the Japanese Patent Application Laid-Open No. 8-126701 discloses a device having a lock adapter on the outer periphery of a liquid discharge portion (mouth).
- This lock adapter has a threaded portion formed on the inner peripheral surface thereof.
- the threaded portion is screwed to, for example, a threaded portion of a connector (connecting tool) to which a tube (tube) is connected. Have been. This threading allows the prefilled syringe to connect to the connector. Then, the prefilled liquid preparation can be injected into the tube via the connector.
- the prefilled syringe equipped with the lock adapter has a problem that there is no cap for sealing the liquid discharge part. For this reason, when connecting the plunger to the connector, the liquid discharge part was exposed to the outside air (air) for a long time, and this liquid discharge part might be contaminated with bacteria. Disclosure of the invention
- a first object of the present invention is to provide a female connector provided with a female threaded portion on the outer peripheral surface, and a syringe capable of easily and reliably connecting any of the female connectors not provided with the female connector.
- the first object of the present invention is achieved by the following (1) to (12) of the present invention.
- a syringe which can be selectively connected to a second female connector having a first female connector and a female screw portion on an outer peripheral surface at a distal end portion,
- a mouth portion having a distal end portion provided with a stepper portion which fits into the lumen portion of the first female connector and the lumen portion of the second female connector, and in which a flow path through which a liquid can pass is formed;
- a lock adapter which is provided on the outer peripheral portion of the lower portion so as to be relatively movable along the axial direction of the mouth portion, and has a female screw portion which is screwed to the female screw portion on the inner peripheral surface.
- the lock adapter is configured to be capable of being retracted to a retracted position on the proximal end side when performing an operation of fitting the female part into the inner cavity part of the first female connector.
- a syringe that can be selectively connected to a second female connector having a first female connector and a female screw portion on an outer peripheral surface at a distal end portion
- a mouth portion having a distal end portion provided with a stepper portion which fits into the lumen portion of the first female connector and the lumen portion of the second female connector, and in which a flow path through which a liquid can pass is formed;
- the outer peripheral portion of the b portion is provided so as to be relatively rotatable around the mouth portion and relatively movable along the axial direction of the mouth portion, and is screwed into the female side threaded portion.
- a mouth adapter having a female side threaded portion on the inner peripheral surface,
- the lock adapter is configured to be retractable to a retracted position on the proximal end side when performing an operation of fitting the female portion into the lumen portion of the first female connector.
- the lock adapter has a rotatable position on the distal end side from the retracted position where the lock adapter can relatively rotate around the mouth portion
- a second object of the present invention is to provide a cap that can be attached to a prefilled syringe provided with a lock adapter and that can maintain a sterilized state around the mouth of a syringe outer cylinder after a sterilization process.
- Another object of the present invention is to provide a method for manufacturing a prefilled syringe using the cap.
- the second object of the present invention is achieved by the following (13) to (16) of the present invention.
- a mouth formed to protrude at the tip and having a stepper portion at the tip, and an outer periphery of the b portion is provided so as to be relatively movable along an axial direction of the mouth, and
- a bottomed cylindrical cap main body having an inner cavity portion, and a female side screwing portion formed on the outer peripheral surface and screwing with the oscillating screw portion;
- At least a part of the inner peripheral surface of the lumen portion is configured to be in close contact with the male taper portion over the entire circumference. And cap.
- a mouth portion protruding at the tip end and having a stepper portion at the tip end portion, and an outer peripheral portion of the b portion provided relatively movably along an axial direction of the mouth portion;
- a syringe outer cylinder provided with a lock adapter having a screw-side threaded portion on the surface, the cap according to the above (13) or (14) attached to the mouth, and a liquid filled in the syringe outer cylinder.
- the cap is attached to the mouth
- a method for producing a prefilled syringe characterized by filling the syringe with the liquid preparation in a sterile environment.
- a mouth formed to protrude at the tip and having a stepper portion at the tip, and an outer periphery of the b portion is provided so as to be relatively movable along an axial direction of the mouth
- FIG. 1 is a semi-longitudinal sectional view of a first embodiment of the syringe of the present invention.
- FIG. 2 is a partial longitudinal sectional view (showing a state where a lock adapter is in a rotatable position) of a distal end portion of the syringe shown in FIG.
- FIG. 3 is a partial longitudinal sectional view of the distal end of the syringe shown in FIG. 1 (showing a state where the lock adapter is at the retracted position and the first female connector is connected).
- FIG. 4 is a partial vertical cross-sectional view of the distal end portion of the syringe shown in FIG. 1 (showing a state where the lock adapter is at the distal end fixed position and the second female connector is connected).
- FIG. 5 is a semi-longitudinal sectional view of a second embodiment of the syringe of the present invention.
- FIG. 6 is a partial longitudinal sectional view of the distal end portion of the syringe shown in FIG.
- FIG. 7 is a partial longitudinal sectional view of the distal end portion of the syringe shown in FIG. 5 (showing a state where the lock adapter is at the retracted position and the first female connector is connected).
- FIG. 8 is a partial longitudinal sectional view of the distal end portion of the syringe shown in FIG. 5 (showing a state where the lock adapter is at the distal end fixed position and the second female connector is connected).
- FIG. 9 is a sectional view taken along line AA in FIG.
- FIG. 10 is a semi-longitudinal sectional view showing an embodiment of the cap of the present invention.
- FIG. 11 is a semi-longitudinal sectional view showing an embodiment of the cap of the present invention.
- Fig. 12 shows the camera with the cap shown in Fig. 10 attached (
- FIG. 1 A first figure.
- Figure 1 3 is a partial longitudinal sectional view of the prefilled syringe t BEST MODE FOR CARRYING OUT THE INVENTION
- FIG. 1 is a semi-longitudinal sectional view of a first embodiment of the syringe of the present invention
- FIGS. 2 to 4 are partial longitudinal sectional views of the tip end of the syringe shown in FIG. 1, respectively.
- the side of the mouth of the outer cylinder main body is referred to as a “tip”, and the opposite side is referred to as a “base end”.
- a syringe 1 shown in FIG. 1 includes an outer cylinder (syringe outer cylinder) 2, a gasket 3 slidable within the outer cylinder 2, and a pusher (plunger rod) 4 for moving the gasket 3.
- the gasket 3 is connected to the tip of the pusher 4.
- the outer cylinder 2 has a bottomed outer cylinder body 21, and a distal end portion is formed with a mouth 22 that is reduced in diameter relative to the body of the outer cylinder body 21. I have.
- a flow path 221 through which a liquid can pass is formed inside the mouth 22, and communicates with a lumen (a space 24 described later) of the outer cylinder main body 21.
- the mouth 22 is provided with a host portion 222 at the tip thereof, and a lock adapter (connection member) 23 is provided on the outer periphery of the mouth 22.
- a lock adapter (connection member) 23 is provided on the outer periphery of the mouth 22.
- a plate-like flange 25 is integrally formed on the outer periphery of the base end of the outer cylinder 2 (the outer cylinder main body 21).
- the operation can be performed by putting a finger on the flange 25.
- the constituent materials of the outer cylinder 2 and the lock adapter 23 described later are, for example, polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly (4-methylpentene-1), polycarbonate, acrylic resin, and acrylonitrile, respectively.
- Polyesters such as butadiene-styrene copolymer, polyethylene terephthalate, polyethylene naphthalate, etc., butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6.6, nylon 6.10, nylon 12) And various resins such as ethylene-vinyl alcohol copolymer, polyarylsulfone, polyethersulfone, methacryl-styrene copolymer, polyarylate, and styrene-acrylonitrile copolymer. Molding in terms of easy, polypropylene, cyclic poly Orefin, polyesters, poly first resin, such as (4-methylpentene one 1) is preferred.
- the constituent materials of the outer cylinder 2 and the lock adapter 23 are preferably substantially transparent in order to secure the visibility of the inside.
- a scale 26 is formed on the outer peripheral surface of the outer cylinder 2 (see FIG. 1). Thereby, the amount of the liquid in the syringe 1 can be grasped.
- a gasket 3 made of an elastic material is accommodated in the outer cylinder 2 (outer cylinder main body 21).
- a plurality of ring-shaped protrusions 31 and 32 are formed over the entire circumference.
- the protrusions 31 and 32 slide tightly against the inner peripheral surface 20 of the outer cylinder 2 to more reliably maintain airtightness (liquid tightness) and improve slidability. Can be achieved.
- two projections 31 and 32 are formed along the longitudinal direction of the gasket 3. That is, the protrusions 31 and 32 are formed at the base end and the tip end of the gasket 3, respectively.
- the formation position, the number, the cross-sectional shape, and the like of the protrusions 31 and 32 are not limited thereto.
- the gasket 3 has a hollow portion opened at the base end surface. A head portion of a pusher 4 described later is inserted (fitted) into this hollow portion.
- the constituent material of the gasket 3 is not particularly limited.
- various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, fluorine rubber, polyurethane, and poly Elastic materials such as various types of thermoplastic elastomers such as ester type, polyamide type, olefin type and styrene type, and mixtures thereof are exemplified.
- the gasket 3 may have a core (not shown) made of, for example, a resin material, and an elastic material may be arranged so as to cover the outer periphery of the core. In this case, a hollow portion is formed in the core.
- a gasket 3 in which all or a part thereof is laminated with a resin may be used.
- the resin used for lamination include polytetrafluoroethylene (PTFE), tetrafluoroethylene-perfluoroethylene copolymer (PFA), and ethylene-tetrafluoroethylene copolymer (ETFE).
- fluorocarbon resins such as tetrafluoroethylene-hexafluoropropylene copolymer (FEP) and high molecular weight polyethylene.
- the gasket 3 is moved in the longitudinal direction within the outer cylinder 2.
- Pusher 4 is connected (mounted).
- the presser 4 has a main body 40 mainly composed of a cross-shaped plate piece having a cross section, a plate member 41 at the tip, and a flange-shaped (plate-shaped) finger at the base end.
- the contact portions 42 are respectively formed integrally with the main body portion 40.
- a head portion (connecting portion) inserted into the hollow portion of the gasket 3 and connected to the gasket 3 is formed at the tip of the main body portion 40.
- the gasket 3 and the pusher 4 are connected by inserting and fitting the head portion into the hollow portion of the gasket 3.
- Examples of the constituent material of the pusher 4 include polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly (4-methylpentene-1), polyacrylonitrile, acrylic resin, acrylonitrile-butadiene-styrene copolymer, and polyethylene terephthalate. And various resins such as polyester such as polyethylene naphthalate, butadiene-styrene copolymer, and polyamide (for example, nylon 6, nylon 6.6, nylon 6.10, nylon 12). Among them, resins such as polypropylene, polyester, and poly (4-methylpentene-1) are preferable in terms of easy molding.
- connection between the gasket 3 and the presser 4 is made by the fitting structure, these connections can be reliably performed, and the gasket 3 and the presser 4 are detached with the operation of the presser 4. Also, the operation of attaching and detaching the pusher 4 to and from the gasket 3 can be easily performed.
- the connecting structure between the gasket 3 and the presser 4 is different from the fitting other than the fitting.
- fixing such as adhesion or fusion, screwing, or the like may be used.
- the liquid is stored in a space 24 (including the flow path 221 of the mouth 22) defined by the gasket 3 and the outer cylinder 2.
- the volume of the space 24 is not particularly limited, but the volume (dead volume) when the gasket 3 is moved and positioned at the tip in the outer cylinder 2 is preferably 0.1 mL or less, and 0.07 mL or less. More preferably, it is below. Thereby, especially when an expensive chemical is used as the liquid, it is possible to effectively use the expensive chemical without wasting it.
- the second female connector 10 can be connected alternatively.
- this point (feature) will be described in detail.
- the mouth 22 is formed integrally with the outer cylinder body 21 at the distal end of the outer cylinder body 21, and the lock adapter 23 is provided on the outer periphery of the mouth 22.
- the mouth portion 22 has a stepper portion 222 at the distal end, the outer diameter and the inner diameter of which gradually decrease toward the distal end.
- the female taper portion 222 fits into the lumen 91 of the first female connector 9 and the lumen 102 of the second female connector 10.
- the gradient of the taper of the stepper section 222 is not particularly limited, but is, for example, about 4Z100 to 8Z100, and more preferably 6Z100.
- the inner diameter (average) of the mouth 22 is not particularly limited, but is preferably 1.2 mm or more, and more preferably about 1.5 to 2.5 mm.
- the length (length L in FIG. 2) of the mouth 22 is not particularly limited, but is about 16 to 2 Omm. And more preferably about 17 to 18.5 mm.
- the lock adapter 23 is relatively rotatable about the mouth 22 and relatively movable along the axial direction of the mouth 22.
- a screw thread (female side screwing part) 2 32 that is screwed into the screw groove (female side screwing part) 101 of the second female connector 10 is provided. Is formed.
- a plurality of ribs (convex portions) 23 are formed on the outer peripheral surface of the lock adapter 23 along the axial direction thereof.
- the ribs 233 have a function of preventing slippage when the lock adapter 23 is rotated with a finger or the like.
- the female taper portion 222 is fitted into the inner cavity portion 102, and the thread 2 3 2 of the lock adapter 23 is screwed into the screw groove 101. As a result, it is connected to the tip of the syringe 1 (see Fig. 4).
- the first female connector 9 is connected to the distal end portion of the syringe 1 by fitting the stepper portion 222 into the lumen portion 91 (see FIG. 3).
- the lock adapter 23 exists in the outer peripheral portion near the female taper portion 22 2, an operation of fitting the female portion 22 2 into the inner cavity portion 9 1 of the first female connector 9 is performed.
- the lock adapter 23 may be in the way, and the operation may not be performed reliably.
- the lock when performing the operation of fitting the stepper portion 222 into the lumen portion 91 of the first female connector 9, the lock is performed to a position on the base end side which does not hinder the operation.
- the adapter 23 can be retracted, and the force and the retracted position (position shown in Fig. 3) It was configured to be fixed to the mouth 22 with.
- the operation of fitting the female taper portion 222 into the lumen portion 91 of the first female connector 9, that is, the operation of connecting the first female connector 9 to the distal end portion of the syringe 1 is easily and reliably performed. It can be carried out.
- a ring-shaped protrusion 231 that projects toward the central axis thereof is formed, and on the outer peripheral surface of the base end side of the mouth portion 22, the shaft is formed.
- a plurality of (four in the present embodiment) ribs 223 projecting outward in the direction are formed.
- the lock adapter 23 is fixed to the opening 22 by pressing the projections 2 3 1 (part of the inner peripheral surface) of the lock adapter 23 against the respective ribs 22 3. That is, the lock adapter 23 is fixed to the opening 22 by fitting in the retracted position.
- the operation of fixing the lock adapter 23 to the mouth portion 22 can be reliably performed, and when performing the operation of releasing the fixing, the release operation should be easily performed.
- the fixing force (fitting force) of the lock adapter 23 to the opening 22 can be easily increased. There is also the advantage that it can be adjusted.
- the plurality of ribs 223 are provided at substantially equal intervals along the circumferential direction of the opening 22. As a result, it is possible to more uniformly (uniformly) fix the mouth portion 22 of the lock adapter 23 in the circumferential direction, so that these can be more stably fixed.
- the height of the tip of such a rib 222 gradually decreases toward the tip. You. That is, the distal end surface of the rib 222 forms an inclined surface. As a result, when performing the operation of moving the lock adapter 23 to the retracted position, the operation can be performed without the protrusion 2 3 1 of the lock adapter 23 catching on the edge of the rib 2 23. It can be performed more smoothly.
- lock adapter 23 may be configured not to be fixed at such a retracted position.
- the fixing force of the lock adapter 23 to the mouth 22 at the retracted position is not particularly limited.
- the lock adapter 2 with the distal end side of the syringe 1 (mouth 22) directed vertically downward. 3 is a force that does not move due to its own weight or more. Thus, it is possible to prevent the lock adapter 23 from easily moving from the retracted position.
- the protruding length (length A in FIG. 3) of the stepper part 22 from the tip of the lock adapter 23 is not less than 7.5 mm. And more preferably about 7.5 to 9.0 mm. If the protruding length is too short, depending on the length (total length) of the first female connector 9, etc., the female taper portion 222 is securely fitted into the inner cavity portion 91 of the first female connector 9. On the other hand, if the protruding length is longer than the upper limit, the overall length of the syringe 1 is undesirably too large.
- the syringe 1 has a rotatable position (see FIG. 2) on the distal end side of the retracted position where the lock adapter 23 can rotate around the opening 22. That is, as shown in each figure, there is a portion where the rib 22 is not provided in the mouth portion 22, and the protrusion 2 31 of the lock adapter 23 is located in this portion. Then The lock adapter 23 is relatively rotatable about the mouth 22. Further, the syringe 1 has a distal end fixed position (see FIG. 4) at which the lock adapter 23 is fixed to the opening 22 on the distal end side from the rotatable position.
- the lock adapter 23 With the lock adapter 23 at the rotatable position, fit the female taper part 22 into the inner cavity 102 of the second female connector 10, and insert the thread 2 32 into the thread groove 101. By screwing, the second female connector 1.0 can be connected to the distal end of the syringe 1. Further, the lock adapter 23 is moved to the distal fixed position, and the second female connector 1 By connecting the second female connector 10 to the distal end of the syringe 1 so that the base end of 0 is located farther from the lock adapter 23 (see Fig. 4), these connections can be made It can be strong.
- a plurality of (four in the present embodiment) ribs 22 protruding outward along the axial direction are provided on the outer peripheral surface of the mouth 22 closer to the base end side than the stepper portion 222. It is formed.
- the lock adapter 23 is fixed to the opening 22 by pressing the projection 2 3 1 (part of the inner peripheral surface) of the lock adapter 23 against each rib 2 26. That is, the lock adapter 23 is fixed to the opening 22 by fitting at the distal end fixed position.
- the operation of fixing the lock adapter 23 to the mouth 22 can be easily and reliably performed.
- the fixing force (fitting force) of the lock adapter 23 to the opening 22 can be easily increased. There is also the advantage that it can be adjusted.
- the plurality of ribs 2 26 are provided at substantially equal intervals along the circumferential direction of the opening 22. Have been. As a result, it is possible to more uniformly (uniformly) fix the mouth portion 22 of the lock adapter 23 in the circumferential direction, so that these can be more stably fixed.
- the height of the base end of such a rib 226 gradually decreases toward the base end. That is, the base end surface of the rib 226 forms an inclined surface. As a result, when performing an operation of moving the lock adapter 23 to the fixed position on the distal end side, the protrusion 2 3 1 of the lock adapter 2 3 does not catch on the edge of the rib 2 Operation can be performed more smoothly.
- the fixing force of the mouth adapter 23 to the mouth portion 22 at the distal end fixed position is such that the lock adapter 23 has its own weight with the base end of the syringe 1 (mouth portion 22) directed vertically downward.
- the force is such that it does not move or more.
- the fixing force of the lock adapter 23 to the mouth 22 at the distal-side fixed position is determined by the state where the second female connector 10 is connected to the distal end of the syringe 1 and the outer cylinder body 21 and the second female.
- the force is higher than that.
- the operation of releasing the connection between the distal end of the syringe 1 and the second female connector 10 can be performed more easily.
- the protruding length (length B in Fig. 4) of the stepper part 22 from the distal end of the lock adapter 23 must be 2.1 mm or more. Preferably, it is more preferably about 2.1 to 3 mm.
- Such a syringe 1 prevents the lock adapter 23 from moving away from the retracted position toward the base end, and prevents the lock adapter 23 from detaching from the mouth 22. It has separation prevention means 6. Hereinafter, these movement control means 5 and separation prevention means 6 will be described respectively.
- the mouth 22 has a diameter-enlarged portion 224a at the base end of which the outer diameter is enlarged, and the outer peripheral surface of the diameter-enlarged portion 224a is continuous with a rib 223.
- a rib 224b having a height substantially equal to that of the rib 223 is formed. Since the outer diameter of the enlarged diameter portion 224 a is larger than the outer diameter of the mouth portion 22, a step portion 225 is formed at the boundary between the rib 223 and the rib 224 b.
- the base end of the lock adapter 2 23 comes into contact with the stepped portion 2 25, and beyond that, the base end side (the outer cylinder body 2 Movement to 1) is regulated (prevented).
- the movement regulating means 5 is constituted by the step portion 225.
- a step portion 227 is formed on the base end side (in the present embodiment, near the distal end of the rib 226) of the male taper portion 222 of the mouth portion 222.
- the disengagement prevention means 6 is constituted by 31.
- the second female connector 10 can be moved from the state where the second female connector 10 is connected to the distal end of the syringe 1 to the lock adapter 23 together with the mouth 2 2 can be prevented from falling off.
- the lock adapter 23 is positioned between the position where the base end thereof abuts the stepped portion 25 and the position where the tip of the protruding portion 2311 abuts the stepped portion 227. It is relatively movable along the 2 axis direction.
- the movement distance is not particularly limited, but is preferably 5.4 mm or more, and more preferably about 5.4 to 6.9 mm. If the moving distance is too short, depending on the length (total length) of the lock adapter 23, etc., when the lock adapter 23 is in the retracted position, the female taper portion 222 may be sufficiently exposed from the lock adapter 23. On the other hand, if the protruding length is longer than the upper limit, the total length of the syringe 1 is undesirably too large.
- the lock adapter 23 is gripped by one hand, the outer cylinder body 21 is gripped by the other hand, and the outer cylinder body 21 is fixed. Move toward. As a result, the lock adapter 23 moves to the retracted position.
- the lock adapter 23 since the lock adapter 23 is in the retracted position, the host adapter 22 is fitted into the lumen 91 of the first female connector 9 without obstruction. Can be performed reliably.
- the mouth adapter 23 is moved to the distal end side of the syringe 1 so that the projections 23 1 are pressed against the ribs 22 26, and the lock adapter 23 is fitted and fixed to the mouth 22.
- the lock adapter 23 since the lock adapter 23 is fitted and fixed to the opening 22, when the lock adapter 23 is rotated, the entire syringe 1 rotates.
- the female taper portion 222 fits into the inner cavity 102 of the second female connector 10, and the thread of the lock adapter 23 fits into the thread groove 101 of the second female connector 10.
- the second female connector 10 can be connected to the distal end of the syringe 1 by screwing the two 3 2.
- FIG. 5 is a semi-longitudinal sectional view of the second embodiment of the syringe of the present invention
- FIGS. 6 to 8 are partial longitudinal sectional views of the tip of the syringe shown in FIG. 5, respectively
- FIG. FIG. 4 is a sectional view taken along line A-A in FIG.
- This embodiment is the same as the first embodiment except that the configuration of the mouth of the outer cylinder and the mouth adapter are different, and that the mouth adapter is not fixed to the mouth at the retracted position.
- the mouth 22A of the outer cylinder 2 has a plurality of (four in the present embodiment) ribs 228a and protrusions 229a on its outer peripheral surface. are doing.
- the rib 228a is formed so as to protrude outward along the axial direction of the mouth portion 22A, from the step portion 225 to the step portion 227.
- the protruding portion 229a is formed so as to protrude outward at a tip end side of a groove 228 formed between two adjacent ribs 228a.
- the lock adapter 23A has a plurality of (four in the present embodiment) claws 234.
- the claw 23 is formed on the inner peripheral surface of the proximal end portion of the lock adapter 23A so as to protrude toward the central axis of the lock adapter 23A.
- the lock adapter 23A is arranged such that the claw 23 is located between the adjacent ribs 22a, that is, the claw 23 is housed in the groove 22b. It is provided at the mouth 22A.
- each rib 2 28 a comes into contact with the claw 2 34 adjacent thereto, thereby restricting the rotation of the lock pad 2 23 A about the mouth 22 A. Therefore, the lock adapter 23A is provided so as to be movable along the axial direction of the mouth 22A without rotating around the mouth 22A within a range in which the lock adapter 23A can move.
- the four ribs 2 28 a are provided at substantially equal intervals along the circumferential direction of the opening 22, so that the lock adapter 23 A And the lock adapter 23A can be easily slid (moved).
- the syringe 1 is positioned at the distal end fixing position where the lock adapter 23 A is fixed to the mouth 22 A (see FIG. 8). Have.
- the height of the protruding portion 229a gradually decreases in each of the distal direction and the proximal direction.
- the distal end face and the proximal end face of the protrusion 229a each constitute an inclined surface.
- the lock adapter 23A moves from the proximal end of the mouth 22A to the distal fixed position or moves from the distal fixed position to the proximal end of the mouth 22A, the lock The operation can be performed more smoothly without the hook 23 of the adapter 23 A catching on the edge of the projection 2 29 a.
- the claw 234 is housed in the fixed position space 229 b formed between the step portion 227 and the protrusion 229 a.
- the lock adapter 23 A is fixed to the mouth 22 A.
- the lock adapter 23 A is configured such that the axial movement of the mouth 22 A of the claw 23 is restricted by the step portion 227 and the protrusion 229 a at the fixed position on the distal end side.
- the mouth is fixed to 22A.
- the lock adapter 23A rotates around the opening 22A when each rib 228a comes into contact with the claw 234 adjacent thereto. Is regulated.
- the number of ribs 2 282 a (groove 228 b), protrusions 229 a, and claws 234 is not limited to four, and is not limited to four, for example, two to three, Or it may be 5 or more.
- the height of the projection 2 229 a and the height of the claw 234 are equal to or slightly lower than the height of the rib 228 a (the depth of the groove 228 b). Is preferred.
- the width of the claw 234 is preferably equal to or slightly smaller than the width of the groove 228b.
- the syringe 1 is rotated while inserting the female taper portion 222 of the syringe 1 into the lumen portion 102 of the second female connector 10 (see FIG. 8).
- the lock adapter 23A is integrally fixed to the mouth 22A, when the syringe 1 is rotated, the lock adapter 23A is rotated accordingly.
- the syringe of the present invention has been described with respect to the illustrated embodiment.
- the present invention is not limited to this.
- the configuration of each part of the syringe may be any of those that can exhibit the same function. can do.
- the tip side fixed position may be provided as needed, and may be omitted.
- the lock adapter may be configured to be fixed to the mouth at the retracted position.
- the syringe of the present invention can be applied to a general-purpose syringe used for drug administration to a patient, drug delivery from an infusion line or a dialysis circuit, mixing of a drug solution, etc. It can also be applied to prefilled syringes filled with (stored).
- a chemical solution is stored in the outer cylinder as needed.
- the type of drug in this drug solution is not particularly limited, and examples thereof include sedatives such as diazepam and midazolam, intravenous anesthetics such as profopol, anesthetic analgesics such as phenynil quinate, and morphine hydrochloride, and hydrochloric acid.
- Topical anesthetics such as mepiva force-in, lidocaine hydrochloride, etc., non-depolarizing muscle relaxants such as suxametonium chloride, pancuronium bromide, epinephrine, catecholamines such as dobamine hydrochloride, dobumin hydrochloride, effe hydrochloride
- Vasopressor drugs such as drin, antihypertensive drugs such as dicardipine hydrochloride, chlorpromazine hydrochloride, and probranol hydrochloride; coronary vasodilators such as isosorbide dinitrate and nitroglycerin; diuretics such as furosemide and aminophylline; and antiarrhythmic drugs such as atoport pin sulfate.
- Prostaglandin E1 bronchodilators such as aminophylline and ephedrine hydrochloride, peptic ulcers such as famotidine, nandrolone decanoate, dexamethasone sodium phosphate, hormones such as besylmethasone and human insulin , Hemostatic agents such as traquinesic acid, blood coagulants such as heparin sodium, antishock agents such as perinastin, antiparkinson agents such as biperidene lactate and levodopa, biminamine agents, correction electrolyte solution, G-CSF Preparations, drugs for liver diseases, human erythropoie such as epoetin alfa Anti-neoplastic agents, such as tin preparations, therapeutic agents for osteoporosis such as elcatonin, synthetic salmon calcitonin preparations, polyvalent enzyme inhibitors, paclitaxel, carpoplatin, cisplatin, etop
- FIG. 13 is a partial longitudinal sectional view of a prefilled syringe.
- the side of the lock adapter is referred to as the “leading end”, and the side of the finger rest of the syringe body is referred to as the “base end”.
- the cap side is referred to as “distal end” and the outer cylinder side is referred to as “proximal end”.
- a liquid preparation 200 such as a drug solution (see FIG. 12) is stored in advance.
- the syringe 1 includes a syringe outer cylinder (outer cylinder) 2, a gasket 3 slidable in the syringe outer cylinder 2, and a plunger (presser) 4 for moving and operating the gasket 3.
- the outer cylinder 2 is formed of a bottomed tubular member having a bottom part 211.
- a plate-like flange 25 is integrally formed on the outer periphery of the base end of the outer cylinder 2. For example, when the pusher 4 is moved relative to the outer cylinder 2, the operation can be performed by putting a finger on the flange 25.
- a mouth 22 which is reduced in diameter and protrudes from the body of the outer cylinder 2 (the outer cylinder main body 2 1) is formed in a body.
- a flow path 221 through which the fluid Q can pass is formed inside the mouth 22, and communicates with the lumen (space 24) of the outer cylinder 2.
- the distal end of the mouth 22 is provided with a stepper portion 222 whose outer diameter and inner diameter gradually decrease toward the distal end.
- a tubular hook adapter (connection member) 23 is provided so as to be relatively movable along the axial direction of the mouth 22.
- a screw thread (male side threaded portion) 2 32 is formed on the inner peripheral surface of the lock adapter 23 .
- the distal end of the mouth 22 is inserted into the lumen 7 11 a of the cap body 7 1 (cap 7), which will be described later, and the screw groove (female side threaded section) 7 1 2 of the cap body 7 1
- the cap 7 of the present invention can be attached to the mouth 22 of the outer cylinder 2 (syringe 1) by screwing the thread 23 2 of the lock adapter 23.
- various hard materials, various glass materials, and the like can be used.
- the constituent material of the outer cylinder 2 is substantially transparent in order to secure the visibility of the inside.
- a scale (not shown) is formed on the outer peripheral surface of the outer cylinder 2.
- the liquid amount of the liquid preparation 200 stored in the syringe 1 can be grasped. Can be.
- a gasket 3 made of an elastic material is accommodated in the outer cylinder 2.
- two ring-shaped protrusions 31 and 32 are formed at predetermined intervals along the axial direction.
- the protrusions 3 1 and 3 2 slide while closely contacting the inner peripheral surface 20 of the outer cylinder 2, thereby ensuring airtightness (liquid tightness) and improving mobility. be able to.
- the gasket 3 has a hollow portion opened at the base end surface. The head of the pusher 4 is inserted (fitted) into this hollow part. '
- the pusher 4 moves the gasket 3 in the outer cylinder 2 in the longitudinal direction.
- the presser 4 has a main body 40 mainly composed of a cross-section plate piece having a cross-section, and has a plate member 41 at its tip, a plate member 43 at an intermediate portion, and a base. At the end, a flange-shaped (plate-shaped) finger pad 42 is formed integrally with the main body 40. The presser 4 is moved in the distal direction by pressing the finger rest 42 with a finger or the like.
- the flange 25 of the outer cylinder 2 is provided with a detachment prevention member 27 that comes into contact with the plate member 43 when the pusher 4 is moved in the proximal direction.
- the detachment preventing member 27 becomes a surface on the distal end side of the detachment preventing member 27.
- 27 1 and the base surface 43 1 of the plate member 43 abut in the space 24 to restrict the movement of the pusher 4. This prevents the gasket 3 and the pusher 4 from being detached from the outer cylinder 2.
- the cap 7 of the present invention is detachably attached to the mouth 22 of the syringe 1 (outer cylinder 2) as described above.
- FIG. 10 and FIG. 11 are semi-longitudinal sectional views each showing an embodiment of the cap of the present invention.
- the cap 7 shown in FIGS. 10 and 11 includes a cap body 71 and a packing (sealing member) 72.
- the cap body 71 is formed of a member having a bottomed cylindrical shape, and has a bore portion 71 1 a and a thread groove 7 12.
- the bore portion 71 1 a is substantially cylindrical in shape, and is formed from the base end face 7 13 of the cap body 71 to the vicinity of the middle portion 7 14.
- a plate-like (disc-shaped) packing 72 made of an elastic material is provided on the distal end surface 71 1 b of the surface surrounding the inner cavity 71 1 a in parallel with the distal end surface 71 1 b. ing.
- the diameter of the packing 72 is preferably equal to or slightly larger than the diameter of the inner cavity 7111a. Thereby, it is possible to prevent the packing 72 from easily detaching from the lumen portion 71a (the cap body 71).
- the screw groove 7 1 2 is formed on the outer peripheral surface 7 15 on the base end side of the cap body 7 1. I have.
- a recess 718 having a substantially regular hexagonal shape in plan view is formed in the tip end surface 717 of the cap body 71.
- a hexagon wrench (not shown) is fitted into the recess 7 18. Then, by applying a torque around the axis of the cap 7 (cap body 7 1) to the hexagon wrench, the cap 7 is rotated, and the thread 2 3 2 of the lock adapter 23 and the thread groove 7 of the cap body 7 1 are rotated. 1 and 2 can be easily and reliably screwed together.
- cap attached state a state in which the cap 7 (cap body 7 1) is attached to the mouth 22 of the outer cylinder 2 (hereinafter, this state is referred to as a “cap attached state”) will be described. Then, the cap 7 is configured such that a part of the inner peripheral surface 711c of the surface surrounding the inner cavity 7111a is in close contact with the oscillating taper portion 22 over the entire circumference.
- a reduced diameter portion 716 in which the inner diameter of the lumen 711 a is reduced is formed at the base end of the lumen 711 a (inner peripheral surface 711 c).
- the reduced diameter portion 7 16 is fitted into the mouth portion 2 2 (ostaper portion 2 2 2).
- the reduced diameter portion 716 and the base end of the mouth portion 22 are configured to be in close contact with each other.
- the lock adapter 23 is located at the distal end of the mouth 22, and the thread 23 2 of the lock adapter 23 is screwed into the thread groove 7 1 2 of the cap 7. ing.
- the inside of the lumen 7111a can be kept in a sealed state.
- the outer surface 22 a of the mouth portion 22 (ostaper portion 22 2) inside the lumen portion 71 1 a can be isolated from the outside of the syringe 1 by the cap 7.
- the packing 72 when the cap is attached, the packing 72 is sandwiched between the distal end surface 7 lib (end surface) of the lumen portion 71 1a and the distal end of the mouth portion 22 to form the mouth portion 22 (flow path 2). 2) is sealed in a liquid-tight (air-tight) manner. It is preferable that the thickness of the packing 72 is equal to or slightly larger than the distance between the front end face 71 1b and the front end of the opening 22. Thereby, the packing 72 with the cap attached is elastically deformed in the thickness direction, so that the opening 22 can be more reliably sealed.
- the hermetically sealed state in the inner cavity portion 711a is maintained by the close contact between the cap body 7 1 (reduced diameter portion 7 16) and the mouth portion 2 (osper taper portion 2 2 2).
- the hermetically sealed state is configured to be maintained by the close contact between the packing 72 and the tip of the mouth 22.
- the constituent material of the cap body 71 for example, polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer , Polyethylene such as polyethylene terephthalate, polyethylene naphthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6.6, nylon 6.10, nylon 12), ethylene-vinyl alcohol copolymer Coalescence, polyallyl sulfone, polyether sulfe There are various resins such as polyethylene, methacrylic styrene copolymer, polyarylate, and styrene-acrylonitrile copolymer, but among them, polypropylene, cyclic polyolefin, polyester, Resins such as poly (4-methylpentene-11) are preferred.
- Examples of the constituent material of the packing 72 include, for example, natural rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, nitrile rubber, chloroprene rubber, butyl rubber, acrylic rubber, ethylene-propylene rubber, hydrin rubber, urethane rubber, Various rubber materials (especially vulcanized) such as silicone rubber and fluorine rubber, styrene, polyolefin, polyvinyl chloride / polyurethane, polyester, polyamide, polybutadiene, and transpolyisoprene , Fluoroelastomer, chlorinated polyethylene, etc., and relatively flexible resin materials such as polyethylene and vinyl chloride resin.One or more of these are mixed. Can be used.
- FIG. 12 is a side view of the prefilled syringe with the cap shown in FIG. 10 attached.
- the outer cylinder 2 and the cap 7 are prepared and sterilized respectively.
- the sterilization at this time is not particularly limited. Gas sterilization using bacteria, hydrogen peroxide or a sterilizing gas such as E ⁇ G, radiation sterilization by irradiation with r-ray or electron radiation, etc. can be used. Hereinafter, each case using such a sterilization method will be described.
- Step using autoclave sterilization Put the outer cylinder 2 and the cap 7 into the autoclave sterilizer. In this state, high-pressure steam R is supplied into the apparatus for sterilization.
- the high-pressure steam R spreads to the inner cavity 711a of the cap 7, and the cap 7, particularly the inner cavity 711a, is sufficiently sterilized (see FIG. 10).
- the high-pressure steam R sufficiently sterilizes the surface of the mouth 22, passes through the flow passage 221, and sufficiently sterilizes the inside of the outer cylinder 2, particularly, the inside of the mouth 22 (flow passage 221) (see FIG. See 13).
- the outer cylinder 2 and the cap 7 are sterilized, respectively, in substantially the same manner as in the step [A1-1].
- the outer cylinder 2 and the cap 7 are stored in a storage member (packaging material) that can be stored, and the opening of the storage member is sealed to keep the inside airtight. In this state, radiation is applied and radiation sterilization is performed.
- a storage member packing material
- the cap 7 and the outer cylinder 2 are transferred into the isolator under a sterile environment, and the cap 7 is attached to the mouth 22 of the outer cylinder 2 (see FIG. 11).
- the mouth portion 22 in the lumen portion 711a is It is possible to prevent contact with the like, and to avoid the risk of generation and adhesion of foreign matter, fine particles, and the like to the mouth 22. Therefore, the outer surface 22 2 a of the mouth 22 can be kept in a sterile state.
- a liquid product 200 that has been subjected to a sterilization treatment (eg, filtration sterilization) in advance is filled into the outer cylinder 2 through an opening at the base end of the outer cylinder 2.
- a sterilization treatment eg, filtration sterilization
- This filling amount corresponds to the volume of the syringe 1 and is set to about 0.1 to 10 O mL.
- the gasket 3 and the presser 4 are attached to complete the prefilled syringe 1 as shown in FIG.
- the prefilled syringe 1 can be produced aseptically.
- the liquid preparations 200 include blood products, carbohydrate injections such as glucose, injections for correcting electrolytes such as sodium chloride and potassium lactate, vitamins, vaccines, injections for antibiotics, contrast agents, steroids. , Protease inhibitors, fat emulsions, various protein preparations, anticancer agents, anesthetics, stimulants, various drug solutions such as narcotics, various diagnostic agents, or distilled water, physiological saline, disinfectants, and nutritional supplements Liquids such as liquid food, alcohol, etc. are stored.
- the outer cylinder 2 and the cap 7 are prepared, and the cap 7 is attached to the mouth 22 of the outer cylinder 2 (see FIG. 11).
- the sterilization at this time includes, for example, radiation sterilization by radiation irradiation such as electron radiation.
- radiation sterilization by radiation irradiation such as electron radiation.
- the prefilled syringe 1 can be aseptically manufactured as in the first embodiment.
- the manufacturing method of the cap and the prefilled syringe of the present invention has been described with reference to the illustrated embodiment.
- the present invention is not limited to this, and each part constituting the cap may have any function that can exhibit the same function. It can be replaced with the one of the configuration. Also, an arbitrary component may be added.
- the cap of the present invention can be used for applications other than the production of a prefilled syringe having the above-mentioned lock adapter. For example, when connecting tubes, a connector that fits a female connector to a female connector is used, and a hook adapter having the above structure may be used for the male connector.
- the portion of the female connector to be inserted into the female connector is not exposed to the external environment until the connection is performed.
- the cap of the present invention can be used to seal the opening of the distal end of the female connector and to maintain the sterilized state of the female connector.
- any of the female connector provided with the female side threaded part on the outer peripheral surface, and the female connector not provided with this can be connected easily and reliably.
- the first taper portion can be moved to the first position. The operation of fitting into the internal cavity of the female connector can be performed more easily and reliably, and as a result, the first female connector can be more reliably connected.
- the second female connector can be fixed more firmly.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003275607A AU2003275607A1 (en) | 2002-10-24 | 2003-10-23 | Method of producing syringe, cap, and prefilled syringe |
US10/532,308 US20060106349A1 (en) | 2002-10-24 | 2003-10-23 | Syringe, cap and method of producing prefilled syringe |
EP03758810A EP1563863A1 (en) | 2002-10-24 | 2003-10-23 | Method of producing syringe, cap, and prefilled syringe |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002-310199 | 2002-10-24 | ||
JP2002310199 | 2002-10-24 | ||
JP2003-347502 | 2003-10-06 | ||
JP2003347503A JP4522071B2 (ja) | 2002-10-24 | 2003-10-06 | シリンジ |
JP2003-347503 | 2003-10-06 | ||
JP2003347502A JP4491215B2 (ja) | 2003-10-06 | 2003-10-06 | プレフィルドシリンジおよびプレフィルドシリンジの製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004037329A1 true WO2004037329A1 (ja) | 2004-05-06 |
Family
ID=32180298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/013540 WO2004037329A1 (ja) | 2002-10-24 | 2003-10-23 | シリンジ、キャップおよびプレフィルドシリンジの製造方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20060106349A1 (ja) |
EP (1) | EP1563863A1 (ja) |
AU (1) | AU2003275607A1 (ja) |
WO (1) | WO2004037329A1 (ja) |
Cited By (1)
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CN103813827A (zh) * | 2011-08-19 | 2014-05-21 | 爱尔康研究有限公司 | 可缩回式路厄锁接头 |
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US20110226646A1 (en) * | 2004-12-06 | 2011-09-22 | Wyrick Ronald E | Kits Containing Medicine Injection Devices And Containers |
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US8231573B2 (en) * | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
US8162899B2 (en) | 2006-05-18 | 2012-04-24 | Hyprotek, Inc. | Intravascular line and port cleaning methods, methods of administering an agent intravascularly, methods of obtaining/testing blood, and devices for performing such methods |
US9592375B2 (en) * | 2006-05-18 | 2017-03-14 | Hyprotek, Inc. | Intravascular line and port cleaning methods, methods of administering an agent intravascularly, methods of obtaining/testing blood, and devices for performing such methods |
JP5127180B2 (ja) * | 2006-07-31 | 2013-01-23 | 株式会社大協精工 | 医療用容器および該医療用容器の処理方法 |
US7977276B2 (en) | 2007-04-12 | 2011-07-12 | Nissan Motor Co., Ltd. | Exhaust gas purifying catalyst and method of producing the same |
US8568365B2 (en) * | 2007-05-08 | 2013-10-29 | Alan Reid | Methods and apparatus for syringe adapter |
USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
JP5694920B2 (ja) * | 2008-05-14 | 2015-04-01 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | クリーナブルインターフェースおよびストレイトラインアタッチメントを備える分離可能な注入セット |
DE102009007250A1 (de) * | 2009-01-26 | 2010-07-29 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Spritze |
US8366682B2 (en) | 2009-03-04 | 2013-02-05 | Washington Biotech Corporation | Medicine injection apparatuses |
WO2010150042A1 (en) * | 2009-06-24 | 2010-12-29 | Becton Dickinson France | Improved luer connector |
ES2666945T3 (es) * | 2009-06-24 | 2018-05-08 | Becton Dickinson France | Conjunto de conexión para un dispositivo de administración de fármacos y método de fabricación de dicho conjunto |
AR078060A1 (es) * | 2009-07-14 | 2011-10-12 | Novartis Ag | Descontaminacion de superficie de contenedores previamente llenados en empaque secundario |
US8468810B2 (en) | 2009-12-04 | 2013-06-25 | Tenneco Automotive Operating Company Inc. | NOx elimination injector firing control circuit |
CN103249450B (zh) | 2010-12-16 | 2015-12-16 | 贝克顿迪金森法国公司 | 适配器和药物输送装置 |
WO2012144026A1 (ja) | 2011-04-20 | 2012-10-26 | 大成化工株式会社 | キャップ付きバレル、プレフィルドシリンジ、及びコネクタ付きキャップ |
EP2545956A1 (en) * | 2011-07-15 | 2013-01-16 | Becton Dickinson France | Drug delivery device and adaptor |
SG11201405136PA (en) * | 2012-02-29 | 2014-11-27 | Hyprotek Inc | Intravascular line and port cleaning methods, methods of administering an agent intravascularly, methods of obtaining/testing blood, and devices for performing such methods |
EP2852430B1 (en) | 2012-05-21 | 2019-04-17 | Carmel Pharma AB | Arrangement in a medical connector device |
KR102299431B1 (ko) | 2013-09-02 | 2021-09-06 | 타이세이카코 카부시키가이샤 | 시린지 및 시린지 세트 |
AU2015320583B2 (en) | 2014-09-25 | 2019-05-23 | Kpr U.S., Llc | Enteral feeding connector |
GB2530808A (en) * | 2014-10-03 | 2016-04-06 | Special Products Ltd | A syringe assembly |
USD797927S1 (en) | 2014-11-06 | 2017-09-19 | Covidien Lp | Male enteral tubing connector |
USD785170S1 (en) | 2014-11-06 | 2017-04-25 | Covidien Lp | Female enteral tubing connector |
US10130770B2 (en) | 2015-06-11 | 2018-11-20 | Kpr U.S., Llc | Enteral feeding syringe assembly |
USD785162S1 (en) | 2015-06-11 | 2017-04-25 | Covidien Lp | Enteral feeding syringe |
US20180126094A1 (en) * | 2016-11-07 | 2018-05-10 | Alan Reid | Methods and apparatus for syringe adapter |
DE102017200007A1 (de) * | 2017-01-02 | 2018-07-05 | Schott Ag | Spritze mit unterschiedlichen Materialien |
EP3777931A4 (en) * | 2018-03-28 | 2021-12-22 | CMC-Pharma Co., Ltd | PRE-FILLED TWO-COMPONENT MIXING SYRINGE KIT |
WO2020255278A1 (ja) * | 2019-06-19 | 2020-12-24 | 清明 本間 | 内視鏡用処置具 |
CN111888645A (zh) * | 2020-08-24 | 2020-11-06 | 深圳安特医疗股份有限公司 | 组合接头和吸液及注液管路组件 |
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- 2003-10-23 AU AU2003275607A patent/AU2003275607A1/en not_active Abandoned
- 2003-10-23 WO PCT/JP2003/013540 patent/WO2004037329A1/ja not_active Application Discontinuation
- 2003-10-23 EP EP03758810A patent/EP1563863A1/en not_active Withdrawn
- 2003-10-23 US US10/532,308 patent/US20060106349A1/en not_active Abandoned
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US6027482A (en) * | 1994-12-12 | 2000-02-22 | Becton Dickinson And Company | Syringe tip cap |
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Also Published As
Publication number | Publication date |
---|---|
EP1563863A1 (en) | 2005-08-17 |
US20060106349A1 (en) | 2006-05-18 |
AU2003275607A1 (en) | 2004-05-13 |
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