WO2022096607A1 - Syringe with luer tip - Google Patents

Syringe with luer tip Download PDF

Info

Publication number
WO2022096607A1
WO2022096607A1 PCT/EP2021/080691 EP2021080691W WO2022096607A1 WO 2022096607 A1 WO2022096607 A1 WO 2022096607A1 EP 2021080691 W EP2021080691 W EP 2021080691W WO 2022096607 A1 WO2022096607 A1 WO 2022096607A1
Authority
WO
WIPO (PCT)
Prior art keywords
luer
syringe
over cap
assembly
barrel
Prior art date
Application number
PCT/EP2021/080691
Other languages
French (fr)
Inventor
Martin Browne
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of WO2022096607A1 publication Critical patent/WO2022096607A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3293—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw

Definitions

  • the present invention relates to a novel syringe design that provides certain advantages compared with known syringe designs.
  • the present invention relates in particular to syringes suitable for use in medical applications, such as administration of diagnostic and therapeutic pharmaceuticals, and specifically to sterile pre-filled syringes.
  • the pre-filled syringe is a medication delivery method where a syringe is filled in a manufacturing facility with a medicine. This is convenient for the end user as it eliminates the need to draw up medicine into a syringe thereby improving the efficiency at which the medicine can be given, reducing contamination risk of the injection, and increasing the accuracy of dosing.
  • a pre-filled syringe can be particularly suitable and some common types of pre-filled syringe for home use include those that contain medicines like insulin and epinephrine.
  • X-ray and magnetic resonance (MR) contrast agents are supplied either in flexible bags, bottles or in pre-filled syringes.
  • the contrast agent In the case of contrast agent supplied in a bottle or bag, the contrast agent must be moved to an automatic injector using syringes, disposable tubes, and connectors. During this process, the end user needs to manipulate the contrast agent and several materials necessary for assembly. Frequent handling and multiple uses of syringe and other materials increases the risk of bacterial contamination.
  • a prefilled syringe requires no syringe filling during the assembly procedure thereby reducing the manipulations required and lowering the risk of contamination, and reducing the time needed for the procedure.
  • the present invention also has advantages in that injection of the plastic can be done in the center allowing completely uniform filling of the mould. It further eliminates one component, which is the conventional sealing tip cap (2a). Removing a material in contact with the injectable fluid also simplifies extractable, leachable and stability studies.
  • Figure 1 illustrates a configuration for a known medical syringe used for supply of pre-filled contrast agent.
  • the syringe includes a barrel (3) in which a Plunger (5) and Plunger rod (4) are positioned to move liquid contents out of the syringe.
  • the tip cap (2a) which includes a silicone coating or a polytetrafluoroethylene (PTFE, Teflon® typically) laminate to avoid sticking, covers the Luer and acts to contain the contents of the pre-filled syringe prior to use and the over cap (2) acts to avoid dislocation of the tip cap (2a) during transport and storage.
  • PTFE polytetrafluoroethylene
  • Luers are part of the standardized Luer fitting system used in virtually all small-scale fluid fittings in order to make leak-free connections between two parts and are common in medical and laboratory instruments.
  • a Luer fitting comprises a maletaper fitting and its mating female part.
  • Syringes are one of the most common instruments using the Luer fitting system wherein the male Luer connection fits to the female needle which either screws into it or fits tightly on top.
  • the present invention provides a syringe tip assembly comprising a Luer wherein the end of the Luer distal to the syringe includes a Luer tip (1 ) that forms a fluid-tight seal and is formed continuously and from the same material as the Luer.
  • the present invention provides a syringe comprising:
  • a plunger assembly that comprises a plunger rod (4) and a plunger (5) wherein the plunger rod (4) moveably fits within the barrel (3), and wherein when the plunger (5) is inside the barrel (3) it forms a fluid-tight seal together with the walls of the barrel (3).
  • the present invention provides a method to manufacture a syringe comprising the following sequential steps:
  • FIG. 2 An embodiment of a syringe of the present invention is shown in Figure 2 comprising a barrel (3), plunger (5) and plunger rod (4) (latter features sometimes referred to as gasket and gasket rod (4)).
  • the syringe tip assembly of the present invention is at the end of the barrel (3) including the Luer.
  • An over cap (2) is shown positioned as if it has just been removed from around the Luer. The act of unscrewing the over cap (2) from the Luer where they have been heat sealed together breaks the Luer tip (1 ) away from the Luer and allows the contents of the syringe to be accessed.
  • the plunger (5) is not a separate component but is part of the plunger rod (4), which seals directly towards the syringe barrel (3) inner surface.
  • FIG. 3 shows a cross-section of an embodiment of the syringe tip assembly of the present invention.
  • the component shown would be manufactured as a single piece by injection moulding from a central point in the Luer tip (1 ) and includes the closed distal tip portion.
  • the thinnest portion of the Luer tip (1 ) is indicated and this is where the Luer tip (1 ) fractures when the bonded over cap (2) is unscrewed or removed (in an optional version where the threads are not utilized).
  • Also shown in this embodiment of the syringe tip assembly is a ring support (6) that would go around the whole circumference if the whole assembly was shown rather than a cross-section.
  • This ring support (6) is designed to provide support for the over cap (2) when it’s in place over the Luer.
  • the ring support (6) ensures that the over cap (2) does not dislocate, even if dropped.
  • the remainder of Figure 3 shows an embodiment of an over cap (2) of the present invention that includes a central opening (2b). When this over cap (2) is fitted over the illustrated assembly the distal tip portion protrudes from the central opening (2b). In one embodiment of the manufacture of a syringe of the present invention, heat is applied to the tip portion and optionally also the central opening (2b) when the over cap (2) has been fitted such that the two components are heat sealed together.
  • the components physically mate together when just the Luer tip (1 ) is heated due to the melted Luer tip (1 ) forming against the serrations shown in the central opening (2b) of the over cap (2).
  • the over cap (2) of the present invention has screw-on functionality by means of compatible threads on the over cap (2) and the Luer.
  • An exemplary over cap (2) could be made of polypropylene or transparent cyclo olefin polymer, preferably of the same material as the barrel (3) if needed to achieve the desired functionality.
  • Figure 4 shows an embodiment of the present invention where the over cap (2) has been fitted to the syringe tip assembly and the Luer and central opening (2b) of the over cap (2) have been bonded or physically mated together by heat. The relative positioning of the over cap (2) with respect to the ring support (6) can also be seen.
  • Step 5 A seguence of manufacturing steps is illustrated in Figure 5.
  • the injection- moulded syringe barrel (3) including the syringe tip assembly of the invention is provided in Step 1 .
  • the tip assembly is moulded with a closed Luer.
  • Step 2 an over cap (2) is fitted over the syringe tip assembly so that a portion of the Luer protrudes out of a central opening (2b) in the over cap (2).
  • the over cap (2) in this embodiment is screwed onto the syringe tip assembly by means of compatible threads on the components. In an alternative embodiment, the threads are not used, and the over cap (2) is merely placed in position by lowering into place.
  • the over cap (2) shown has a serrated central opening (2b).
  • Step 3 illustrates the result of heat sealing the Luer to the central opening (2b) of the over cap (2) to bond the components together.
  • the serrations of the central opening (2b) help to ensure that the connection remains when the over cap (2) is unscrewed, thereby breaking the seal of the Luer and permitting access to the contents of the syringe.
  • Figure 6 shows cross-sectional views of Steps 1 and 3 of Figure 5.
  • syringe of the present invention can be manufactured more cheaply. There is one less material in contact with the product and as a result fewer extractable and leachable studies are required.
  • the tip cap (2a) of the prior art requires a silicone laminate surface or silicone oiled surfaces to avoid sticking so the cost and effort to provide this component is completely avoided with the present invention. Free silicone is also undesired in injections.
  • a syringe according to the present invention can be moulded with a closed Luer. This would allow for centre injection, which is normally desired, but which is impossible for a cylindrical hollow part like a known syringe.
  • For the manufacture of certain known syringes either two injection points diametrically positioned are used, or one asymmetric position.
  • the advantages include faster setup with one part less to control pre-injection, less waste, better hygiene (the fingers are away from the Luer), and tamper evidence by breaking the tip.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A novel syringe arrangement is provided by the present invention. Advantages are provided both in simplification of the manufacturing process and for the end user.

Description

SYRINGE WITH LUER TIP
Technical Field of the Invention
The present invention relates to a novel syringe design that provides certain advantages compared with known syringe designs. The present invention relates in particular to syringes suitable for use in medical applications, such as administration of diagnostic and therapeutic pharmaceuticals, and specifically to sterile pre-filled syringes.
Description of Related Art
The pre-filled syringe is a medication delivery method where a syringe is filled in a manufacturing facility with a medicine. This is convenient for the end user as it eliminates the need to draw up medicine into a syringe thereby improving the efficiency at which the medicine can be given, reducing contamination risk of the injection, and increasing the accuracy of dosing. Where the end-user is the patient, a pre-filled syringe can be particularly suitable and some common types of pre-filled syringe for home use include those that contain medicines like insulin and epinephrine.
X-ray and magnetic resonance (MR) contrast agents are supplied either in flexible bags, bottles or in pre-filled syringes. In the case of contrast agent supplied in a bottle or bag, the contrast agent must be moved to an automatic injector using syringes, disposable tubes, and connectors. During this process, the end user needs to manipulate the contrast agent and several materials necessary for assembly. Frequent handling and multiple uses of syringe and other materials increases the risk of bacterial contamination. In contrast, a prefilled syringe requires no syringe filling during the assembly procedure thereby reducing the manipulations required and lowering the risk of contamination, and reducing the time needed for the procedure. The present invention also has advantages in that injection of the plastic can be done in the center allowing completely uniform filling of the mould. It further eliminates one component, which is the conventional sealing tip cap (2a). Removing a material in contact with the injectable fluid also simplifies extractable, leachable and stability studies.
Figure 1 illustrates a configuration for a known medical syringe used for supply of pre-filled contrast agent. The syringe includes a barrel (3) in which a Plunger (5) and Plunger rod (4) are positioned to move liquid contents out of the syringe. The tip cap (2a), which includes a silicone coating or a polytetrafluoroethylene (PTFE, Teflon® typically) laminate to avoid sticking, covers the Luer and acts to contain the contents of the pre-filled syringe prior to use and the over cap (2) acts to avoid dislocation of the tip cap (2a) during transport and storage. Luers are part of the standardized Luer fitting system used in virtually all small-scale fluid fittings in order to make leak-free connections between two parts and are common in medical and laboratory instruments. A Luer fitting comprises a maletaper fitting and its mating female part. Syringes are one of the most common instruments using the Luer fitting system wherein the male Luer connection fits to the female needle which either screws into it or fits tightly on top.
Summary of the Invention
In one aspect the present invention provides a syringe tip assembly comprising a Luer wherein the end of the Luer distal to the syringe includes a Luer tip (1 ) that forms a fluid-tight seal and is formed continuously and from the same material as the Luer.
In another aspect the present invention provides a syringe comprising:
(i)a hollow cylindrical barrel (3) having a first end and a second end and walls therebetween defining a volume, wherein said barrel (3) comprises at said first end the syringe tip assembly as defined in any one of Claims 1 -4;
(ii)a plunger assembly that comprises a plunger rod (4) and a plunger (5) wherein the plunger rod (4) moveably fits within the barrel (3), and wherein when the plunger (5) is inside the barrel (3) it forms a fluid-tight seal together with the walls of the barrel (3).
In a further aspect the present invention provides a method to manufacture a syringe comprising the following sequential steps:
(a)injection moulding a hollow cylindrical barrel (3) comprising the syringe tip assembly defined in Claim 1 ;
(b)injection moulding an over cap (2) wherein said over cap (2) includes a central opening (2b) and is configured to removably fit over said syringe tip assembly such that a section of the distal end of said assembly protrudes through said central opening (2b);
(c)heating the Luer tip (1 ) so that the assembly and the over cap (2) are heat sealed together.
Detailed Description of the Preferred Embodiments
To more clearly and concisely describe and point out the subject matter of the claimed invention, definitions are provided hereinbelow for specific terms used throughout the present specification and claims. Any exemplification of specific terms herein should be considered as a non-limiting example.
The terms “comprising” or “comprises” have their conventional meaning throughout this application and imply that the agent or composition must have the essential features or components listed, but that others may be present in addition. The term ‘comprising’ includes as a preferred subset “consisting essentially of” which means that the composition has the components listed without other features or components being present.
An embodiment of a syringe of the present invention is shown in Figure 2 comprising a barrel (3), plunger (5) and plunger rod (4) (latter features sometimes referred to as gasket and gasket rod (4)). The syringe tip assembly of the present invention is at the end of the barrel (3) including the Luer. An over cap (2) is shown positioned as if it has just been removed from around the Luer. The act of unscrewing the over cap (2) from the Luer where they have been heat sealed together breaks the Luer tip (1 ) away from the Luer and allows the contents of the syringe to be accessed. In one embodiment the plunger (5) is not a separate component but is part of the plunger rod (4), which seals directly towards the syringe barrel (3) inner surface.
The top drawing of Figure 3 shows a cross-section of an embodiment of the syringe tip assembly of the present invention. The component shown would be manufactured as a single piece by injection moulding from a central point in the Luer tip (1 ) and includes the closed distal tip portion. The thinnest portion of the Luer tip (1 ) is indicated and this is where the Luer tip (1 ) fractures when the bonded over cap (2) is unscrewed or removed (in an optional version where the threads are not utilized). Also shown in this embodiment of the syringe tip assembly is a ring support (6) that would go around the whole circumference if the whole assembly was shown rather than a cross-section. This ring support (6) is designed to provide support for the over cap (2) when it’s in place over the Luer. The ring support (6) ensures that the over cap (2) does not dislocate, even if dropped. The remainder of Figure 3 shows an embodiment of an over cap (2) of the present invention that includes a central opening (2b). When this over cap (2) is fitted over the illustrated assembly the distal tip portion protrudes from the central opening (2b). In one embodiment of the manufacture of a syringe of the present invention, heat is applied to the tip portion and optionally also the central opening (2b) when the over cap (2) has been fitted such that the two components are heat sealed together. In the embodiment shown in Figure 3 the components physically mate together when just the Luer tip (1 ) is heated due to the melted Luer tip (1 ) forming against the serrations shown in the central opening (2b) of the over cap (2). In one embodiment the over cap (2) of the present invention has screw-on functionality by means of compatible threads on the over cap (2) and the Luer. An exemplary over cap (2) could be made of polypropylene or transparent cyclo olefin polymer, preferably of the same material as the barrel (3) if needed to achieve the desired functionality.
Figure 4 shows an embodiment of the present invention where the over cap (2) has been fitted to the syringe tip assembly and the Luer and central opening (2b) of the over cap (2) have been bonded or physically mated together by heat. The relative positioning of the over cap (2) with respect to the ring support (6) can also be seen.
A seguence of manufacturing steps is illustrated in Figure 5. The injection- moulded syringe barrel (3) including the syringe tip assembly of the invention is provided in Step 1 . The tip assembly is moulded with a closed Luer. In Step 2 an over cap (2) is fitted over the syringe tip assembly so that a portion of the Luer protrudes out of a central opening (2b) in the over cap (2). The over cap (2) in this embodiment is screwed onto the syringe tip assembly by means of compatible threads on the components. In an alternative embodiment, the threads are not used, and the over cap (2) is merely placed in position by lowering into place. The over cap (2) shown has a serrated central opening (2b). Step 3 illustrates the result of heat sealing the Luer to the central opening (2b) of the over cap (2) to bond the components together. The serrations of the central opening (2b) help to ensure that the connection remains when the over cap (2) is unscrewed, thereby breaking the seal of the Luer and permitting access to the contents of the syringe.
Figure 6 shows cross-sectional views of Steps 1 and 3 of Figure 5.
There are a number of very useful advantages of the present invention.
Having one less component compared to known syringe designs means the syringe of the present invention can be manufactured more cheaply. There is one less material in contact with the product and as a result fewer extractable and leachable studies are required.
The tip cap (2a) of the prior art requires a silicone laminate surface or silicone oiled surfaces to avoid sticking so the cost and effort to provide this component is completely avoided with the present invention. Free silicone is also undesired in injections.
With the arrangement of the prior art leak-detection is impossible by visual means and it is required to do this e.g. using an X-ray machine to inspect.
A syringe according to the present invention can be moulded with a closed Luer. This would allow for centre injection, which is normally desired, but which is impossible for a cylindrical hollow part like a known syringe. For the manufacture of certain known syringes either two injection points diametrically positioned are used, or one asymmetric position.
For the end user the advantages include faster setup with one part less to control pre-injection, less waste, better hygiene (the fingers are away from the Luer), and tamper evidence by breaking the tip.
This written description uses examples to disclose the invention, including the best mode, and also to enable any person skilled in the art to practice the invention, including making and using any devices or systems and performing any incorporated methods. The patentable scope of the invention is defined by the claims, and may include other examples that occur to those skilled in the art. Such other examples are intended to be within the scope of the claims if they have structural elements that do not differ from the literal language of the claims, or if they include equivalent structural elements with insubstantial differences from the literal languages of the claims. All patents and patent applications mentioned in the text are hereby incorporated by reference in their entireties, as if they were individually incorporated.

Claims

Claims
(1 ) A syringe tip assembly comprising a Luer wherein the end of the Luer distal to the syringe includes a Luer tip (1 ) (1 ) that forms a fluid-tight seal and is formed continuously and from the same material as the Luer.
(2) The syringe tip assembly as defined in Claim 1 which further comprises an over cap (2) (2) that is configured to removably engage with the Luer.
(3) The syringe tip assembly as defined in Claim 2 wherein the overcap and the Luer are bonded together of physically integrated by heat deformation.
(4) The syringe tip assembly as defined in Claim 3 wherein the over cap (2) and the Luer are both made from a thermoplastic material and are bonded together of physically integrated by heat.
(5) A syringe comprising:
(i) a hollow cylindrical barrel (3) (3) having a first end and a second end and walls therebetween defining a volume, wherein said barrel (3) comprises at said first end the syringe tip assembly as defined in any one of Claims 1-4;
(ii) a plunger assembly that comprises a plunger rod (4) and a plunger (5) wherein the plunger rod (4) moveably fits within the barrel (3), and wherein when the plunger (5) is inside the barrel (3) it forms a fluid-tight seal together with the walls of the barrel (3).
(6) A method to manufacture a syringe comprising the following sequential steps:
(a) injection moulding a hollow cylindrical barrel (3) comprising the syringe tip assembly defined in Claim 1 ;
(b) injection moulding an over cap (2) wherein said over cap (2) includes a central opening (2b) and is configured to removably fit over said syringe tip assembly such that a section of the distal end of said assembly protrudes through said central opening (2b);
(c) heating the Luer tip (1 ) so that the assembly and the over cap (2) are heat sealed together.
-7-
(7) The method as defined in Claim 6 wherein step (c) also includes heating the central opening (2b).
(8) The method as defined in Claim 6 wherein the heated Luer tip (1 ) physically integrates into the edges of the central opening (2b) to allow the function of breaking the Luer tip (1 ) away from the Luer, when the over cap (2) is subsequently removed.
-8-
PCT/EP2021/080691 2020-11-09 2021-11-04 Syringe with luer tip WO2022096607A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2017671.5A GB202017671D0 (en) 2020-11-09 2020-11-09 Novel syringe
GB2017671.5 2020-11-09

Publications (1)

Publication Number Publication Date
WO2022096607A1 true WO2022096607A1 (en) 2022-05-12

Family

ID=74046375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2021/080691 WO2022096607A1 (en) 2020-11-09 2021-11-04 Syringe with luer tip

Country Status (2)

Country Link
GB (1) GB202017671D0 (en)
WO (1) WO2022096607A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040159564A1 (en) * 2001-01-12 2004-08-19 Eakins Michael N. Tamper evident syringe barrel
US20090149817A1 (en) * 2006-01-19 2009-06-11 Laboratoire Aguettant Pre-Filled Hypodermic Syringe Fitted With a Stoppering Device
US20130079726A1 (en) * 2009-12-16 2013-03-28 Graham John Madin Syringes
US20150141934A1 (en) * 2013-11-18 2015-05-21 Excelsior Medical Corporation Medicant injection device
US20150246185A1 (en) * 2012-09-26 2015-09-03 Transcoject Gmbh Prefilled syringe

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040159564A1 (en) * 2001-01-12 2004-08-19 Eakins Michael N. Tamper evident syringe barrel
US20090149817A1 (en) * 2006-01-19 2009-06-11 Laboratoire Aguettant Pre-Filled Hypodermic Syringe Fitted With a Stoppering Device
US20130079726A1 (en) * 2009-12-16 2013-03-28 Graham John Madin Syringes
US20150246185A1 (en) * 2012-09-26 2015-09-03 Transcoject Gmbh Prefilled syringe
US20150141934A1 (en) * 2013-11-18 2015-05-21 Excelsior Medical Corporation Medicant injection device

Also Published As

Publication number Publication date
GB202017671D0 (en) 2020-12-23

Similar Documents

Publication Publication Date Title
US5899889A (en) Prefilled syringe
US9345642B2 (en) Vial adapter for a needle-free syringe
KR102401509B1 (en) Tip cap assembly for closing an injection system
US7175609B1 (en) Syringe and method of using
US9108031B2 (en) Connector having a membrane, for connecting a syringe to a container or tubing
EP0847770B1 (en) Prefilled syringe
US11964141B2 (en) System and method for safety syringe
WO2004037329A1 (en) Method of producing syringe, cap, and prefilled syringe
JP2015503994A (en) Multiple dose vials and methods
US10512591B2 (en) Cartridge assembly for an injection system
AU2013370560A1 (en) Cartridge assembly for an injection system
WO2022096607A1 (en) Syringe with luer tip
CN109963792B (en) Rotary operated container closure
US11925793B2 (en) Apparatus for injecting a fluid, comprising a needle assembly and a needle retention device for retaining a needle of the needle assembly when attached to the apparatus, and needle retention device
JP2024516256A (en) Valve, method for manufacturing the valve, cap for a fluid container with such a valve, fluid container with such a cap, and method for manufacturing such a cap
JP2020146523A (en) Medication delivery device
CN102028619B (en) Can the container of accommodating different injection medicament
US20130261591A1 (en) Vial device and methods
JP2580793Y2 (en) Pressure-resistant holder for container and syringe
JPH0910281A (en) Mouth part structure for medicine container
US20240017012A1 (en) System and method for multiple site dispensing or injection
US20240252758A1 (en) Injection system and method
EP4316550A1 (en) Tip cap assembly for an injection system

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21806227

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21806227

Country of ref document: EP

Kind code of ref document: A1