WO2004001396A1 - 分析装置とそれに使用する分析用ディスク - Google Patents
分析装置とそれに使用する分析用ディスク Download PDFInfo
- Publication number
- WO2004001396A1 WO2004001396A1 PCT/JP2003/006790 JP0306790W WO2004001396A1 WO 2004001396 A1 WO2004001396 A1 WO 2004001396A1 JP 0306790 W JP0306790 W JP 0306790W WO 2004001396 A1 WO2004001396 A1 WO 2004001396A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- analysis
- disc
- optical disk
- switching state
- power control
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
Definitions
- the present invention relates to an analyzer for setting an object to be analyzed such as blood on an optical disk for analysis and tracing the object to be analyzed to capture it as a video.
- an analyzer for setting an object to be analyzed such as blood on an optical disk for analysis and tracing the object to be analyzed to capture it as a video.
- an analysis target to be tested is set in a certain portion of the disk using the reproduction function of the optical disk, and the image of the analysis target is traced.
- the optical disc 101 has a track 103 of an aluminum reflective layer formed on the surface of the base board 102 as shown in FIGS. 6 and 7, and a fine track is formed on the track. Information is recorded in an uneven pit and group 104.
- 105 is a protective layer.
- the optical disk 101 is read by the laser beam Ph from the pickup 107 while rotating the optical disk 101 in the direction of arrow C by the disk motor 106.
- the pickup 107 is screwed into a feed screw 109 driven by a traverse motor 108, and the servo control circuit 110 is driven by a track 1 based on the reproduction output of the pickup 107.
- the traverse motor 108 is driven to move the pickup 107 in the radial direction so that the tracing follows the 03.
- servo control times The road 110 detects the address information recorded on the track 103 and drives the disk drive 106 so that the linear velocity becomes constant (CLV control).
- the irradiation position of the laser beam P h on the optical disk 101 is determined not only by the driving of the traverse module 108 but also by the tracking function provided inside the pickup 107. (Not shown), the optical path of one laser beam Ph is driven in the left-right direction (radial direction) as needed with respect to the surface of the optical disc 101 to control the position of the track 10 accurately while controlling the position. 3 is configured to trace.
- the analysis target 111 is arranged on the optical disc 101 as shown in FIG. 6 and FIG.
- the analyzer using the optical disk drive technology of this type reads the reflected light from the object to be analyzed 111 by the PD (photodetector) 117 of the pickup 107 shown in FIG.
- the processing is to obtain an image of the analysis target 1 1 1.
- FIG. 8 shows a power control circuit of the pickup 1'07 shown in FIG.
- the laser light output for reading information written in the optical disc 101's pit group and information for each driving support is supplied from the LD (laser-LED) 113 of the pickup 107.
- the emitted light is emitted to the optical disk 101 and simultaneously emitted to the front monitor 114, which is the monitor light receiving element.
- the output voltage of the front monitor 114 is input to an APC circuit (auto power control circuit) 115.
- APC circuit 1 1 5 The feedback control is performed such that the laser drive circuit 1 16 is operated so that the voltage of the front monitor 114 is constant and the output of the LD 113 is constant. The same control is performed without exception in the analyzer. This is effective for stably capturing signals such as pit group on the disk.
- the LD 113 and the PD 117 of the pickup 107 are provided on one side of the optical disk 101, and the optical disk 101 is irradiated with the light. Although it is configured to process the detection signal of the reflected laser beam, the pickup 107 is arranged with the LD 113 and PD 117 across the optical disc 101 as shown by the phantom line in FIG.
- the optical disc drive pickup 107 configured to process the detection signal of the laser light emitted and transmitted to the optical disc 101 is also the same as FIG.
- the laser output that is optimal for acquiring the image of the portion to be analyzed 111 is not always optimal for capturing the pit group or the like. This is because the pit that is provided inside the optical disc 101 is not optimal. This is due to the difference between the laser path for acquiring information from the group and the laser path for acquiring images from the analysis target. Disclosure of the invention
- the present invention provides a laser output that is optimal for obtaining information from the pit group, and that is optimal for acquiring images from the object to be analyzed.
- an analyzer capable of obtaining an output.
- the present invention is configured such that when acquiring an image to be analyzed, the detected image is controlled by the brightness of the detected image. As a result, an optimal contrast image can be obtained when acquiring an image from the analysis target.
- An analyzer according to the present invention is directed to an analyzer that irradiates an analysis optical disc, in which an analysis target is partially disposed, with detection light, and reads the state of the analysis target.
- a laser that generates one light —As a power control system of the element, a first switching state in which the output of the laser light is detected by a monitor and a feedback element so that the value of the monitor and the light receiving element becomes constant.
- a second switching state is provided in which the average value of the detection signal of the laser beam reflected or transmitted by the analysis optical disc is fed back so that the average value is constant, and the reading position of the analysis target of the analysis optical disc is detected.
- the power control system is switched to the second switching state at the reading position of the analysis target optical disk.
- the provided control means for switching the is characterized in that a mark provided immediately before the reading position of the analysis optical disk is detected, and the power control system of the laser element is switched to the second switching state. Further, the control means detects a mark provided immediately before the reading position of the analysis optical disk and detects a mark provided in the power control system of the laser element.
- An analysis disc is an analysis disc capable of reproducing traces of pits or groups, and having a data area for controlling the rotation of the disc and a reading area in which an analysis target is arranged. A mark is recorded immediately before the rotation direction with respect to the reading area in which the analysis target is arranged, over a radial section of the reading area.
- the analysis disk of the present invention is capable of reproducing traces of pits or dubs, and has a data area for controlling the rotation of the disk and a reading area on which an analysis target is arranged. Wherein marks are recorded at positions immediately before and after in a rotational direction with respect to a reading area in which the analysis target is arranged, over a radial section of the reading area.
- BRIEF DESCRIPTION OF THE FIGURES Figure 1 shows the configuration of the analyzer of the present invention.
- FIG. 2 is a plan view of the analysis optical disk used in the embodiment.
- FIG. 3 is a cross-sectional view of the analysis optical disk of the embodiment.
- Figure 4 is a plan view of an analysis optical disc with marks at the front and rear positions of the analysis target.
- Fig. 5 is a block diagram of a general optical disk drive.
- Fig. 6 is a partially cutaway plan view of a conventional analytical optical disc.
- Fig. 7 is a cross-sectional view of a conventional analytical optical disc.
- Figure 8 is a block diagram of a conventional pick-up power control circuit.
- Fig. 9 shows a cross section of an optical disc for analysis showing the arrangement of the LD (Laser LED) and PD (Photo Detector) of a conventional transmission pickup.
- FIGS. 5 to 9 The same components as those in the conventional example shown in FIGS. 5 to 9 are denoted by the same reference numerals and described.
- FIG. 1 shows a power control circuit of the pickup 107 of the analyzer according to the embodiment of the present invention
- FIGS. 2 to 4 show an optical disc 201 for analysis used in this analyzer.
- the analysis optical disk 201 has a mixture of an analyte and a reagent corresponding to the test item set on the optical disk as an analysis target 111, and the analysis target 111 is arranged. Radial direction of the reading area only at the position immediately before the rotation direction C with respect to the read area 203 Mark 204 is recorded over the section (in the direction of arrow A).
- a specific example of the position of the analysis target 111 on the analysis optical disk 201 and the mark 204 on the analysis optical disk 201 is configured as shown in FIG.
- the analysis target 111 is provided between the surface 202a of the optical disk 201 for analysis and the track 103.
- the mark 204 is formed by printing ink 205 or the like in a band shape on the back surface 202 b of the optical disk 201 for analysis.
- reference numeral 206 denotes a pit or group formed on the mirror-finished track 103.
- Reference numeral 207 denotes a land formed on a mirror-finished track 103.
- the input signal to be fed back to the APC circuit 115 is switched by the switching switch 208.
- This switching switch 208 feeds either the output signal of the front monitor 114 or the output signal of the integrating circuit 209 to the APC circuit 115, and this switching switch 208 is a microphone. It is controlled by the mouth computer 210 as follows.
- the microcomputer 210 switches the output signal of the front monitor 114 so that the output signal is fed back to the APC circuit 115. 8 to control the laser output of LD113 so that the output voltage of front monitor 114 is constant.
- the microcomputer 210 is output from the output signal of the PD 117 during operation.
- the microcomputer 210 integrates the output signal of the video signal processing circuit 112 and outputs the signal of the integration circuit 209 to the APC circuit 115.
- the switching switch 208 is automatically switched so as to be fed back to the optical disk 201 for analysis to clarify the brightness of the image of the analysis target 111 of the analysis optical disk 201.
- the reflected light from the analysis object 111 is captured by the PD 117 and input to the video signal processing circuit 112. Since what is traced on the analysis optical disk 201 is a laser light point (point), the reflection of light changes with time depending on the analysis object 111. This is averaged by the integrating circuit 209, and the feedback of the laser beam output is controlled so that the brightness (contrast) of the video output from the video signal processing circuit 112 becomes an average value.
- the microcomputer 210 detects the mark 204 and sends the switching switch 209 switched to feed back the output signal of the integrating circuit 209 to the APC circuit 115, to the mark 209. 4 is configured to return to the state where the output voltage of the front monitor 114 is fed back to the APC circuit 115 after a specified time from the detection of the signal.
- the mark 204 was formed by printing the ink 2 ⁇ 5 in a band shape on the back surface 202 b of the optical disk for analysis 201, as shown in FIG. 3 (b) or (c). It can also be configured in such a manner.
- the mark 210 can be realized in the same manner by providing a part 211 where the mirror surface is missing in a part of the mirror-finished track 103. More specifically, it is a BCA (see Burst Cutting Area DVD standard Ver.1.0 or the like) provided on one side of the mirror of DVD.
- BCA Burst Cutting Area DVD standard Ver.1.0 or the like
- the mark 204 can be realized in the same manner by providing a deformed portion 212 having a shape such as a concave portion in a part of the outer shape of the analysis optical disk 201. More specifically, the shape of the disk itself is modified to change the light reflection from the data track surface.
- the mark 204 is arranged immediately before the rotation area with respect to the reading area 203 on which the analysis object 111 is arranged, and the microcomputer 210 marks the mark 204.
- the switching switch 208 is configured to return to the original state after a specified time from the recognition, but as shown in Fig. 4, the analysis optical disk is located not only immediately before the analysis target 1 1 1 but also immediately after it.
- a similar mark is provided on the microcomputer 210 so as to detect the mark provided immediately after the object 1 11 to be analyzed and to switch the switch 208 back to the original state. 10 can also be configured.
- the mark 204 of the optical disc 201 for analysis in each of the above embodiments was formed by printing, lack of mirror surface, or irregular shape, but the pit or group 206 of the optical disc 201 for analysis or The mark may be provided on the land 207.
- the track data portion can be distinguished from the reading area 203 in which the analysis target 111 is arranged.
- the track data portion can be distinguished from the reading area 203 in which the analysis target 111 is arranged.
- It consists of pits such as E F M ⁇ M F M. More specifically, a pre-pit, LPP (land pre-pit) (which is engraved as a pre-pit on a land portion between tracks to be recorded as address information in DVD-RZRW. , CAPA (DVD-Pre-pit for RAM address) etc. Some modulation such as wobble is superimposed on a group or land.
- the detailed position and range of the mark composed of pits, groups, or lands on the analysis disk 201 are set in the rotation direction immediately before the reading area 203 on which the analysis target 111 is arranged. Either the position or the front-back position, which is the same as in each of the above embodiments.
- An analyzer using the analysis disk 201 on which the mark is formed in a pit, group, or land is provided by a pickup 107 that reads the mark and detects a mark position.
- a pickup 107 that reads the mark and detects a mark position.
- the LD 113 and the PD 117 of the pickup 107 are provided on one side of the optical disc 101, and the laser radiated and reflected on the optical disc 101 is provided.
- Process light detection signal However, the pickup 107 is arranged with the LD 113 and the PD 117 sandwiching the optical disc 101, and the laser beam transmitted through the optical disc 101 is transmitted.
- the power control circuit of the pickup 107 of the optical disk drive configured to process the detection signal is the same as that in FIG.
- the output of the laser light is monitored by the monitor and the light receiving element as a power control system of the laser element for generating the laser light irradiated on the analysis optical disk.
- a control means for switching the power control system to the second switching state is provided, so that an optimal laser output for acquiring information from the pit group can be obtained. It is possible to obtain a laser output which is optimal for obtaining images from the analysis target and obtain images with good contrast.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03733181A EP1526371B1 (en) | 2002-06-19 | 2003-05-29 | Analyzing apparatus |
US10/518,028 US7423246B2 (en) | 2002-06-19 | 2003-05-29 | Analysis apparatus and analysis disc used for the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002177828A JP4148705B2 (ja) | 2002-06-19 | 2002-06-19 | 分析装置 |
JP2002-177828 | 2002-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004001396A1 true WO2004001396A1 (ja) | 2003-12-31 |
Family
ID=29996496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/006790 WO2004001396A1 (ja) | 2002-06-19 | 2003-05-29 | 分析装置とそれに使用する分析用ディスク |
Country Status (5)
Country | Link |
---|---|
US (1) | US7423246B2 (ja) |
EP (1) | EP1526371B1 (ja) |
JP (1) | JP4148705B2 (ja) |
CN (1) | CN100458404C (ja) |
WO (1) | WO2004001396A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2096374A2 (en) | 2003-05-21 | 2009-09-02 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005108342A (ja) * | 2003-09-30 | 2005-04-21 | Pioneer Electronic Corp | 駆動装置及び情報処理装置 |
US7496026B2 (en) * | 2004-12-11 | 2009-02-24 | Hewlett-Packard Development Company, L.P. | Optical disc and method of printing optical disc |
US7910356B2 (en) | 2005-02-01 | 2011-03-22 | Purdue Research Foundation | Multiplexed biological analyzer planar array apparatus and methods |
WO2006083917A2 (en) | 2005-02-01 | 2006-08-10 | Purdue Research Foundation | Laser scanning interferometric surface metrology |
US20070023643A1 (en) | 2005-02-01 | 2007-02-01 | Nolte David D | Differentially encoded biological analyzer planar array apparatus and methods |
GB0525665D0 (en) * | 2005-12-16 | 2006-01-25 | Filtrona Plc | Detector and method of detection |
US7659968B2 (en) | 2007-01-19 | 2010-02-09 | Purdue Research Foundation | System with extended range of molecular sensing through integrated multi-modal data acquisition |
US7787126B2 (en) | 2007-03-26 | 2010-08-31 | Purdue Research Foundation | Method and apparatus for conjugate quadrature interferometric detection of an immunoassay |
JP2009093715A (ja) * | 2007-10-04 | 2009-04-30 | Sony Corp | データ記録再生装置、カメラ装置、および、データ記録再生方法 |
CN104007074B (zh) * | 2014-05-26 | 2016-03-23 | 上海理工大学 | 双光束分光光度计及其采集分析处理方法 |
Citations (7)
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JPH02269938A (ja) * | 1989-04-11 | 1990-11-05 | Idemitsu Petrochem Co Ltd | 分析装置 |
JPH03225278A (ja) * | 1990-01-31 | 1991-10-04 | Idemitsu Petrochem Co Ltd | 液体試料分析用ディスク |
JPH04233462A (ja) * | 1990-12-28 | 1992-08-21 | Idemitsu Petrochem Co Ltd | 免疫学的定量分析方法 |
JPH055741A (ja) * | 1990-10-09 | 1993-01-14 | Idemitsu Petrochem Co Ltd | 免疫学的定量分析方法 |
JPH07209185A (ja) * | 1994-01-13 | 1995-08-11 | Yokogawa Electric Corp | 表面散乱形濁度計 |
JPH10320855A (ja) * | 1997-03-31 | 1998-12-04 | Internatl Business Mach Corp <Ibm> | データ記憶ディスク及びそれを備えるデータ記憶システム |
WO1999024822A1 (en) * | 1997-11-12 | 1999-05-20 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
Family Cites Families (7)
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GB9418981D0 (en) * | 1994-09-21 | 1994-11-09 | Univ Glasgow | Apparatus and method for carrying out analysis of samples |
JP3372396B2 (ja) * | 1995-06-14 | 2003-02-04 | 株式会社日立製作所 | 光ディスク装置 |
WO1999009394A1 (en) * | 1997-08-15 | 1999-02-25 | Alexion Pharmaceuticals, Inc. | Apparatus for performing assays at reaction sites |
JP4068752B2 (ja) * | 1999-03-02 | 2008-03-26 | シャープ株式会社 | 光ディスク装置 |
WO2002016037A1 (en) * | 2000-08-21 | 2002-02-28 | Burstein Technologies, Inc | Methods and apparatus for optical disc data acquisition using physical synchronization markers |
AU2002228872A1 (en) * | 2000-11-09 | 2002-05-21 | Burstein Technologies, Inc. | Disc drive system and methods for use with bio-discs |
US7026131B2 (en) * | 2000-11-17 | 2006-04-11 | Nagaoka & Co., Ltd. | Methods and apparatus for blood typing with optical bio-discs |
-
2002
- 2002-06-19 JP JP2002177828A patent/JP4148705B2/ja not_active Expired - Lifetime
-
2003
- 2003-05-29 CN CNB03814266XA patent/CN100458404C/zh not_active Expired - Fee Related
- 2003-05-29 US US10/518,028 patent/US7423246B2/en active Active
- 2003-05-29 EP EP03733181A patent/EP1526371B1/en not_active Expired - Lifetime
- 2003-05-29 WO PCT/JP2003/006790 patent/WO2004001396A1/ja active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02269938A (ja) * | 1989-04-11 | 1990-11-05 | Idemitsu Petrochem Co Ltd | 分析装置 |
JPH03225278A (ja) * | 1990-01-31 | 1991-10-04 | Idemitsu Petrochem Co Ltd | 液体試料分析用ディスク |
JPH055741A (ja) * | 1990-10-09 | 1993-01-14 | Idemitsu Petrochem Co Ltd | 免疫学的定量分析方法 |
JPH04233462A (ja) * | 1990-12-28 | 1992-08-21 | Idemitsu Petrochem Co Ltd | 免疫学的定量分析方法 |
JPH07209185A (ja) * | 1994-01-13 | 1995-08-11 | Yokogawa Electric Corp | 表面散乱形濁度計 |
JPH10320855A (ja) * | 1997-03-31 | 1998-12-04 | Internatl Business Mach Corp <Ibm> | データ記憶ディスク及びそれを備えるデータ記憶システム |
WO1999024822A1 (en) * | 1997-11-12 | 1999-05-20 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
Non-Patent Citations (1)
Title |
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See also references of EP1526371A4 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2096374A2 (en) | 2003-05-21 | 2009-09-02 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
US8991387B2 (en) | 2003-05-21 | 2015-03-31 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
US9370629B2 (en) | 2003-05-21 | 2016-06-21 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
Also Published As
Publication number | Publication date |
---|---|
US20050259260A1 (en) | 2005-11-24 |
JP4148705B2 (ja) | 2008-09-10 |
US7423246B2 (en) | 2008-09-09 |
CN100458404C (zh) | 2009-02-04 |
EP1526371A1 (en) | 2005-04-27 |
JP2004020452A (ja) | 2004-01-22 |
CN1662806A (zh) | 2005-08-31 |
EP1526371A4 (en) | 2010-07-14 |
EP1526371B1 (en) | 2013-01-23 |
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