WO2003092584A3 - Agents regulant, inhibant ou modulant l'activite et/ou l'expression du facteur de croissance du tissu conjonctif (ctgf) utilises comme moyen unique pour reduire la pression intraoculaire et traiter les retinopathies glaucomateuses/neuropathies optiques - Google Patents
Agents regulant, inhibant ou modulant l'activite et/ou l'expression du facteur de croissance du tissu conjonctif (ctgf) utilises comme moyen unique pour reduire la pression intraoculaire et traiter les retinopathies glaucomateuses/neuropathies optiques Download PDFInfo
- Publication number
- WO2003092584A3 WO2003092584A3 PCT/US2003/012521 US0312521W WO03092584A3 WO 2003092584 A3 WO2003092584 A3 WO 2003092584A3 US 0312521 W US0312521 W US 0312521W WO 03092584 A3 WO03092584 A3 WO 03092584A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ctgf
- growth factor
- connective tissue
- intraocular pressure
- tissue growth
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0309623-8A BR0309623A (pt) | 2002-04-30 | 2003-04-18 | Agentes que regulam. inibem ou modulam a atividade e/ou a expressão do fator de crescimento de tecido conjuntivo (ctgf) como um único meio de diminuir a pressão intraocular e tratar retinopatias glaucomatosas/neuropatias ópticas |
US10/510,585 US7351407B2 (en) | 2002-04-30 | 2003-04-18 | Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (CTGF) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
MXPA04009471A MXPA04009471A (es) | 2002-04-30 | 2003-04-18 | Agentes que regulan, inhiben o modulan la actividad y/o expresion de factor de crecimiento de tejido de conexion (ctgf) como un medio unico para ambos reducir la presion intraocular y tratar retinopatias glaucomatosas/neuropatias opticas. |
JP2004500769A JP2005523928A (ja) | 2002-04-30 | 2003-04-18 | 眼内圧の低下および緑内障性網膜症/眼神経障害の処置の両方のための独特の手段としての、結合組織増殖因子(ctgf)の活性および/または発現を調節するか、阻害するか、または調整する薬剤 |
KR10-2004-7016310A KR20040104566A (ko) | 2002-04-30 | 2003-04-18 | 안압 저하 및 녹내장성 망막병증/시신경병증 치료를 위한특유의 수단으로서의 결합 조직 성장 인자 (ctgf)의활성 및/또는 발현 조절, 저해, 또는 변조제 |
CA002482789A CA2482789A1 (fr) | 2002-04-30 | 2003-04-18 | Agents regulant, inhibant ou modulant l'activite et/ou l'expression du facteur de croissance du tissu conjonctif (ctgf) utilises comme moyen unique pour reduire la pression intraoculaire et traiter les retinopathies glaucomateuses/neuropathies optiques |
EP03718502A EP1497420A4 (fr) | 2002-04-30 | 2003-04-18 | Agents regulant, inhibant ou modulant l'activite et/ou l'expression du facteur de croissance du tissu conjonctif (ctgf) utilises comme moyen unique pour reduire la pression intraoculaire et traiter les retinopathies glaucomateuses/neuropathies optiques |
AU2003221762A AU2003221762B2 (en) | 2002-04-30 | 2003-04-18 | Agents which regulate, inhibit or modulate the activity and/or expression of connective tissue growth factor (CTGF) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
US12/024,821 US20080176964A1 (en) | 2002-04-30 | 2008-02-01 | Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (ctgf) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
US12/970,662 US20110092523A1 (en) | 2002-04-30 | 2010-12-16 | Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (ctgf) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37660602P | 2002-04-30 | 2002-04-30 | |
US60/376,606 | 2002-04-30 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/024,821 Continuation US20080176964A1 (en) | 2002-04-30 | 2008-02-01 | Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (ctgf) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003092584A2 WO2003092584A2 (fr) | 2003-11-13 |
WO2003092584A3 true WO2003092584A3 (fr) | 2004-07-01 |
Family
ID=29401375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/012521 WO2003092584A2 (fr) | 2002-04-30 | 2003-04-18 | Agents regulant, inhibant ou modulant l'activite et/ou l'expression du facteur de croissance du tissu conjonctif (ctgf) utilises comme moyen unique pour reduire la pression intraoculaire et traiter les retinopathies glaucomateuses/neuropathies optiques |
Country Status (15)
Country | Link |
---|---|
US (3) | US7351407B2 (fr) |
EP (2) | EP2221054A1 (fr) |
JP (3) | JP2005523928A (fr) |
KR (1) | KR20040104566A (fr) |
CN (1) | CN1650001A (fr) |
AR (1) | AR039511A1 (fr) |
AU (2) | AU2003221762B2 (fr) |
BR (1) | BR0309623A (fr) |
CA (1) | CA2482789A1 (fr) |
MX (1) | MXPA04009471A (fr) |
PL (1) | PL378030A1 (fr) |
RU (1) | RU2332213C2 (fr) |
TW (1) | TWI288640B (fr) |
WO (1) | WO2003092584A2 (fr) |
ZA (1) | ZA200408021B (fr) |
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EP2221054A1 (fr) | 2002-04-30 | 2010-08-25 | Alcon, Inc. | Inhibiteurs de CDK pour abaisser la pression intraoculaire |
TW200526224A (en) * | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
CN101884789A (zh) | 2004-02-11 | 2010-11-17 | 法布罗根股份有限公司 | Ctgf作为糖尿病肾病的治疗靶点 |
EP1742965B1 (fr) | 2004-04-28 | 2012-10-24 | Fibrogen, Inc. | Traitements pour le cancer du pancreas |
PL1781787T3 (pl) | 2004-08-23 | 2018-01-31 | Sylentis Sau | Leczenie zaburzeń oka charakteryzowanych przez podwyższone ciśnienie wewnątrzgałkowe przy użyciu siRNA |
US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
TWI386225B (zh) | 2004-12-23 | 2013-02-21 | Alcon Inc | 用於治療眼睛病症的結締組織生長因子(CTGF)RNA干擾(RNAi)抑制技術 |
US20060275797A1 (en) * | 2005-03-21 | 2006-12-07 | Alcon Manufacturing, Ltd. | Use of agents which inhibit connective tissue growth factor (CTGF) binding and signaling via the TrkA/p75NTR receptor complex for the prevention and treatment of CTGF-mediated ocular disorders |
WO2007108541A1 (fr) | 2006-03-23 | 2007-09-27 | Senju Pharmaceutical Co., Ltd. | Composition ophtalmique comprenant de la gomme de xanthane et du glucose |
JP2009544734A (ja) * | 2006-07-25 | 2009-12-17 | アルコン リサーチ, リミテッド | 目の障害の予防および処置のための内皮分化遺伝子ファミリー3(edg−3、s1p3)レセプターのアンタゴニスト |
US20080057072A1 (en) * | 2006-08-31 | 2008-03-06 | Alcon Manufacturing, Ltd. | Antagonists of ci-m6p/igf2r for prevention and treatment of ctgf-mediated ocular disorders |
US20090202524A1 (en) * | 2007-10-31 | 2009-08-13 | Alcon Research, Ltd. | Pai-1 expression and activity inhibitors for the treatment of ocular disorders |
US20100158897A1 (en) * | 2006-10-31 | 2010-06-24 | Alcon Research, Ltd. | Pai-1 modulators for the treatment of ocular disorders |
EP2077829A2 (fr) * | 2006-10-31 | 2009-07-15 | Alcon Research, Ltd. | Modulateurs de liaison de pai-1 utilises dans le traitement de troubles oculaires |
US7807629B1 (en) | 2007-06-05 | 2010-10-05 | Alcon Research, Ltd. | Use of bradykinin and related B2R agonists to treat ocular hypertension and glaucoma |
US8173668B1 (en) | 2007-06-05 | 2012-05-08 | Alcon Research, Ltd. | Use of non-peptidic bradykinin receptor agonists to treat ocular hypertension and glaucoma |
WO2011002525A1 (fr) | 2009-07-02 | 2011-01-06 | Fibrogen, Inc. | Procédés pour le traitement de la dystrophie musculaire |
WO2011056234A1 (fr) | 2009-11-06 | 2011-05-12 | Fibrogen, Inc. | Traitement de troubles induits par un rayonnement |
JP2013516495A (ja) | 2010-01-11 | 2013-05-13 | イノテック ファーマシューティカルズ コーポレイション | 眼圧を低下させる組合せ、キット、および方法 |
JP2013523739A (ja) | 2010-03-26 | 2013-06-17 | イノテック ファーマシューティカルズ コーポレイション | N6−シクロペンチルアデノシン(cpa)、cpa誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法 |
TW201210584A (en) | 2010-08-18 | 2012-03-16 | Alcon Res Ltd | Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma |
WO2012061811A2 (fr) | 2010-11-05 | 2012-05-10 | Fibrogen, Inc. | Procédé de traitement de maladies de remodelage des poumons |
BR112014018413A8 (pt) | 2012-01-26 | 2017-07-11 | Inotek Pharmaceuticals Corp | Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo |
CN104781402A (zh) | 2012-09-05 | 2015-07-15 | 西伦蒂斯私人股份公司 | siRNA及其在用于治疗和/或预防眼部病症的方法和组合物中的应用 |
CN105188714A (zh) | 2013-03-15 | 2015-12-23 | 伊诺泰克制药公司 | 眼用配制品 |
WO2015132303A1 (fr) | 2014-03-04 | 2015-09-11 | Sylentis Sau | Arnsi et leur utilisation dans des méthodes et des compositions pour le traitement et/ou la prévention d'affections oculaires |
ES2844899T3 (es) | 2015-12-10 | 2021-07-23 | Fibrogen Inc | Métodos para el tratamiento de enfermedades de las neuronas motoras |
DE102018107621A1 (de) * | 2018-03-29 | 2019-10-02 | Imedos Systems GmbH | Vorrichtung und Verfahren zur Untersuchung der metabolischen Autoregulation |
KR20190115725A (ko) | 2018-04-03 | 2019-10-14 | 한국과학기술연구원 | 찰콘 유도체를 포함하는 시신경 보호용 조성물 |
US20200369759A1 (en) | 2019-05-23 | 2020-11-26 | Fibrogen, Inc. | Methods of treatment of muscular dystrophies |
KR102231354B1 (ko) | 2020-05-22 | 2021-03-24 | 한국과학기술연구원 | 찰콘 유도체를 포함하는 시신경 보호용 조성물 |
AU2021329413A1 (en) * | 2020-08-21 | 2023-03-16 | University Of Tennessee Research Foundation | Methods of neuroprotection and uses thereof |
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WO2003027275A1 (fr) * | 2001-09-27 | 2003-04-03 | Alcon, Inc. | Inhibiteurs de la glycogene synthase kinase-3 (gsk-3) pour le traitement du glaucome |
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EP2221054A1 (fr) | 2002-04-30 | 2010-08-25 | Alcon, Inc. | Inhibiteurs de CDK pour abaisser la pression intraoculaire |
-
2003
- 2003-04-18 EP EP10163480A patent/EP2221054A1/fr not_active Withdrawn
- 2003-04-18 WO PCT/US2003/012521 patent/WO2003092584A2/fr active Application Filing
- 2003-04-18 KR KR10-2004-7016310A patent/KR20040104566A/ko not_active Application Discontinuation
- 2003-04-18 EP EP03718502A patent/EP1497420A4/fr not_active Withdrawn
- 2003-04-18 JP JP2004500769A patent/JP2005523928A/ja not_active Withdrawn
- 2003-04-18 CN CNA038096048A patent/CN1650001A/zh active Pending
- 2003-04-18 RU RU2004134733/14A patent/RU2332213C2/ru not_active IP Right Cessation
- 2003-04-18 US US10/510,585 patent/US7351407B2/en not_active Expired - Fee Related
- 2003-04-18 CA CA002482789A patent/CA2482789A1/fr not_active Abandoned
- 2003-04-18 AU AU2003221762A patent/AU2003221762B2/en not_active Ceased
- 2003-04-18 PL PL378030A patent/PL378030A1/pl unknown
- 2003-04-18 BR BR0309623-8A patent/BR0309623A/pt not_active IP Right Cessation
- 2003-04-18 MX MXPA04009471A patent/MXPA04009471A/es active IP Right Grant
- 2003-04-29 TW TW092109994A patent/TWI288640B/zh not_active IP Right Cessation
- 2003-04-30 AR ARP030101523A patent/AR039511A1/es unknown
-
2004
- 2004-10-05 ZA ZA200408021A patent/ZA200408021B/en unknown
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2006
- 2006-02-13 JP JP2006035819A patent/JP2006131643A/ja active Pending
-
2008
- 2008-02-01 US US12/024,821 patent/US20080176964A1/en not_active Abandoned
- 2008-12-24 AU AU2008264214A patent/AU2008264214B2/en not_active Ceased
-
2010
- 2010-09-16 JP JP2010208643A patent/JP2010280723A/ja not_active Withdrawn
- 2010-12-16 US US12/970,662 patent/US20110092523A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003027275A1 (fr) * | 2001-09-27 | 2003-04-03 | Alcon, Inc. | Inhibiteurs de la glycogene synthase kinase-3 (gsk-3) pour le traitement du glaucome |
Non-Patent Citations (1)
Title |
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See also references of EP1497420A4 * |
Also Published As
Publication number | Publication date |
---|---|
PL378030A1 (pl) | 2006-02-20 |
ZA200408021B (en) | 2006-07-26 |
RU2332213C2 (ru) | 2008-08-27 |
US20110092523A1 (en) | 2011-04-21 |
CN1650001A (zh) | 2005-08-03 |
US20080176964A1 (en) | 2008-07-24 |
AU2008264214B2 (en) | 2011-03-31 |
JP2010280723A (ja) | 2010-12-16 |
EP2221054A1 (fr) | 2010-08-25 |
JP2005523928A (ja) | 2005-08-11 |
WO2003092584A2 (fr) | 2003-11-13 |
US20050234075A1 (en) | 2005-10-20 |
EP1497420A4 (fr) | 2005-04-27 |
AU2008264214A1 (en) | 2009-01-29 |
MXPA04009471A (es) | 2005-01-25 |
AR039511A1 (es) | 2005-02-23 |
RU2004134733A (ru) | 2005-05-10 |
JP2006131643A (ja) | 2006-05-25 |
CA2482789A1 (fr) | 2003-11-13 |
AU2003221762B2 (en) | 2008-09-25 |
EP1497420A2 (fr) | 2005-01-19 |
BR0309623A (pt) | 2005-02-09 |
AU2003221762A1 (en) | 2003-11-17 |
US7351407B2 (en) | 2008-04-01 |
KR20040104566A (ko) | 2004-12-10 |
TWI288640B (en) | 2007-10-21 |
TW200403985A (en) | 2004-03-16 |
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