RU2004134733A - Агенты, которые регулируют, ингибируют или модулируют активность и/или экспрессию факторов роста соединительной ткани (фрст), в качестве уникальных средств для снижения внутриглазного давления и лечения глаукоматозных ретинопатий/оптических невропатий - Google Patents

Агенты, которые регулируют, ингибируют или модулируют активность и/или экспрессию факторов роста соединительной ткани (фрст), в качестве уникальных средств для снижения внутриглазного давления и лечения глаукоматозных ретинопатий/оптических невропатий Download PDF

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RU2004134733A
RU2004134733A RU2004134733/14A RU2004134733A RU2004134733A RU 2004134733 A RU2004134733 A RU 2004134733A RU 2004134733/14 A RU2004134733/14 A RU 2004134733/14A RU 2004134733 A RU2004134733 A RU 2004134733A RU 2004134733 A RU2004134733 A RU 2004134733A
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glaucoma
composition
frst
expression
connective tissue
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RU2004134733/14A
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RU2332213C2 (ru
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Дебра Л. ФЛИНОР (US)
Дебра Л. ФЛИНОР
Аллан ШЕПАРД (US)
Аллан ШЕПАРД
Насрин ДЖЕЙКОБСОН (US)
Насрин ДЖЕЙКОБСОН
Иок-Хоу ПАН (US)
Иок-Хоу ПАН
Эббот Ф. КЛАРК (US)
Эббот Ф. КЛАРК
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Алькон, Инк. (Ch)
Алькон, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (13)

1. Способ снижения внутриглазного давления и обеспечение нейропротекторного действия у пациента, нуждающегося в этом, включающий введение терапевтически эффективного количества композиции, включающей, по меньшей мере, один ненуклеотидный или небелковый агент, который ингибирует экспрессию, сигнализацию или биологические функции фактора роста соединительной ткани (ФРСТ) и фармацевтически приемлемый носитель.
2. Способ по п.1, в котором указанное введение является наружным, внутрикамерным или посредством имплантанта.
3. Способ по п.1, в котором общая концентрация указанного ингибитора ФРСТ в указанной композиции составляет от 0,01 до 2%.
4. Способ по п.1, в котором указанный пациент страдает от глаукомы или глазной гипертензии.
5. Способ по п.4, в котором указанная глаукома является глаукомой при нормальном глазном давлении.
6. Способ снижения внутриглазного давления у пациента, нуждающегося в этом, включающий введение терапевтически эффективного количества композиции, включающей по меньшей мере один ненуклеотидный или небелковый агент, который ингибирует экспрессию, сигнализацию или биологические функции фактора роста соединительной ткани (ФРСТ) и фармацевтически приемлемый носитель.
7. Способ по п.6, в котором указанное введение является наружным, внутрикамерным или посредством имплантанта.
8. Способ по п.6, в котором общая концентрация указанного ингибитора ФРСТ в указанной композиции составляет от 0,01 до 2%.
9. Способ по п.6, в котором указанный пациент страдает глаукомой или глазной гипертензией.
10. Способ по п.9, в котором указанная глаукома является глаукомой при нормальном глазном давлении.
11. Способ предотвращения потери поля зрения, связанной с первичной открытоугольной глаукомой (ПОУГ), включающий введение пациенту, нуждающемуся в этом, композиции, включающей ненуклеотидный или небелковый агент, который ингибирует экспрессию фактора роста соединительной ткани (ФРСТ) так, что внутриглазное давление контролируется и обеспечивается защита ганглиозных клеток сетчатки и диска глазного нерва.
12. Композиция для снижения внутриглазного давления и обеспечения нейропротекторного действия у пациента, нуждающегося в этом, включающая по меньшей мере один агент, который ингибирует экспрессию, сигнализацию или биологические функции фактора роста соединительной ткани (ФРСТ) и фармацевтически приемлемый носитель.
13. Композиция по п.12, в которой общая концентрация указанного ингибитора ФРСТ составляет от 0,01 до 2%.
RU2004134733/14A 2002-04-30 2003-04-18 Агенты, которые регулируют, ингибируют или модулируют активность и/или экспрессию факторов роста соединительной ткани (фрст), в качестве уникальных средств для снижения внутриглазного давления и лечения глаукоматозных ретинопатий/оптических невропатий RU2332213C2 (ru)

Applications Claiming Priority (2)

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US37660602P 2002-04-30 2002-04-30
US60/376,606 2002-04-30

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RU2004134733A true RU2004134733A (ru) 2005-05-10
RU2332213C2 RU2332213C2 (ru) 2008-08-27

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US (3) US7351407B2 (ru)
EP (2) EP1497420A4 (ru)
JP (3) JP2005523928A (ru)
KR (1) KR20040104566A (ru)
CN (1) CN1650001A (ru)
AR (1) AR039511A1 (ru)
AU (2) AU2003221762B2 (ru)
BR (1) BR0309623A (ru)
CA (1) CA2482789A1 (ru)
MX (1) MXPA04009471A (ru)
PL (1) PL378030A1 (ru)
RU (1) RU2332213C2 (ru)
TW (1) TWI288640B (ru)
WO (1) WO2003092584A2 (ru)
ZA (1) ZA200408021B (ru)

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TW200403985A (en) 2004-03-16
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AR039511A1 (es) 2005-02-23
AU2008264214B2 (en) 2011-03-31
US20050234075A1 (en) 2005-10-20
BR0309623A (pt) 2005-02-09
AU2008264214A1 (en) 2009-01-29
JP2006131643A (ja) 2006-05-25
TWI288640B (en) 2007-10-21
WO2003092584A3 (en) 2004-07-01
US20080176964A1 (en) 2008-07-24
EP2221054A1 (en) 2010-08-25
JP2010280723A (ja) 2010-12-16
EP1497420A4 (en) 2005-04-27
ZA200408021B (en) 2006-07-26
JP2005523928A (ja) 2005-08-11
US7351407B2 (en) 2008-04-01
KR20040104566A (ko) 2004-12-10
US20110092523A1 (en) 2011-04-21
CA2482789A1 (en) 2003-11-13
AU2003221762B2 (en) 2008-09-25
MXPA04009471A (es) 2005-01-25
RU2332213C2 (ru) 2008-08-27
WO2003092584A2 (en) 2003-11-13
PL378030A1 (pl) 2006-02-20
AU2003221762A1 (en) 2003-11-17

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